7,759 results match your criteria Hypersomnia Primary


Narcolepsy: Diagnosis and management.

Cleve Clin J Med 2018 Dec;85(12):959-969

Assistant Professor and Consultant, Department of Neurology and Center for Sleep Medicine, Mayo Clinic, Rochester, MN, USA.

Narcolepsy is a chronic disorder of hypersomnia that can have a significant impact on quality of life and livelihood. However, with appropriate treatment, its symptoms are manageable, and a satisfying personal, social, and professional life can still be enjoyed. Greater awareness of the disorder promotes accurate and efficient diagnosis. Read More

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December 2018

Evaluating Transfer of Modafinil Into Human Milk During Lactation: A Case Report.

J Clin Sleep Med 2018 Nov 29. Epub 2018 Nov 29.

Abstract: We present a case of a 27-year-old woman in whom idiopathic hypersomnolence was diagnosed in adolescence with adequate symptomatic control on daily dosage of 250 mg of modafinil. She maintained this dosage throughout her pregnancy and during the peripartum period, but did not breastfeed her newborn because of a lack of information on the transmission of modafinil in human breast milk. Samples of her breast milk were obtained at various times over a 24-hour period and analyzed using liquid chromatography mass spectrometry. Read More

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November 2018
1 Read

Disease-specific attention impairment in disorders of chronic excessive daytime sleepiness.

Sleep Med 2018 Oct 15;53:133-140. Epub 2018 Oct 15.

Institute of Sleep Medicine and Neuromuscular Disorders, University Hospital Muenster, Germany. Electronic address:

Objective: Patients with chronic excessive daytime sleepiness (EDS) complain of substantial attention deficits. However, their underlying neuronal dysfunction is largely unknown. Previous studies showed similar attention performances in central disorders of hypersomnolence suggesting that EDS-related cognitive impairment is independent of its cause. Read More

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October 2018

Hypersomnia as an isolated symptom of neuromyelitis optica.

Intern Med J 2018 Dec;48(12):1546-1547

Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.

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December 2018

Diaphragmatic dysfunction.

Pulmonology 2018 Nov 30. Epub 2018 Nov 30.

Pneumology Service, University Hospital Complex of Santiago, Santiago de Compostela, Spain; Interdisciplinary Research Group in Pulmonology, Institute of Sanitary Research of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.

The diaphragm is the main breathing muscle and contraction of the diaphragm is vital for ventilation so any disease that interferes with diaphragmatic innervation, contractile muscle function, or mechanical coupling to the chest wall can cause diaphragm dysfunction. Diaphragm dysfunction is associated with dyspnoea, intolerance to exercise, sleep disturbances, hypersomnia, with a potential impact on survival. Diagnosis of diaphragm dysfunction is based on static and dynamic imaging tests (especially ultrasound) and pulmonary function and phrenic nerve stimulation tests. Read More

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November 2018
1 Read

A retrospective analysis of clinical characteristics of childhood narcolepsy.

Paediatr Child Health 2018 Sep 5;23(6):e95-e101. Epub 2018 Mar 5.

Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Ontario.

Aim: Narcolepsy, encompassing excessive daytime sleepiness (EDS), cataplexy, sleep paralysis and hypnogogic hallucinations, was previously considered rare in childhood. Recently, cases of childhood narcolepsy have increased significantly and the reasons for this may include the increasing awareness of narcolepsy as well as the H1N1 vaccination. The aim of this study was to describe the clinical characteristics of childhood narcolepsy, specifically focusing on cataplexy subtypes that may facilitate early recognition of narcolepsy. Read More

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September 2018
5 Reads
1.540 Impact Factor

Specific T-cell activation in peripheral blood and cerebrospinal fluid in central disorders of hypersomnolence.

Sleep 2018 Nov 16. Epub 2018 Nov 16.

Institute for Sleep Medicine and Neuromuscular Disorders, University of Muenster, Germany.

An autoimmune-mediated process in the pathophysiology of narcolepsy type 1 (NT1) is highly suspicious, if this pathomechanism is transferable to other types of central disorders of hypersomnolence (CDH), is still controversial. The association of NT1 with HLA-class-II system implicates a T-cell-mediated autoimmunity, in which helper CD4+ T-cells and cytotoxic CD8+ T-cells may be pathogenic.This study aimed to identify specific immune profiles in peripheral blood (PB) and cerebrospinal fluid (CSF) in different types of CDH. Read More

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November 2018
4 Reads

Mononucleosis: A Possible Cause of Idiopathic Hypersomnia.

Front Neurol 2018 31;9:922. Epub 2018 Oct 31.

Service de Physiologie Clinique et de l'Exercice (Pole Hospitalier NOL), CHU Nord, Faculté de Médecine Jacques Lisfranc, Université Jean Monnet, SNA EPIS EA 4607, Université de Lyon, Saint-Étienne, France.

Idiopathic hypersomnia (IH) is a rare central hypersomnia of unknown physiopathology. In this study, we determine if the presence of infectious mononucleosis evaluated by serological markers of Epstein Barr virus infection plays a role in this hypersomnia. Ten patients with a suspicion of IH underwent to clinical assessment, 24 h polysomnography, and serologic testing for mononucleosis including Viral Capside Antigen (VCA) IgG, the VCA IgM, and the EBV nuclear antigen (EBNA). Read More

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October 2018
3 Reads

New Drug Discovery from Medicinal Plants and Phytoconstituents for Depressive Disorders.

CNS Neurol Disord Drug Targets 2018 Nov 14. Epub 2018 Nov 14.

Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara. Turkey.

Depression, a risk factor for several serious diseases, is a highly prevalent and life-threatening psychiatric disorder. It can affect the individual's position in life and reduce the living standards. The research on the use of medicinal plants in treating this disease has increased enormously because of the possible low rehabilitation rate and side effects of available synthetic drugs, such as sexual dysfunction, nausea, fatigue, insomnia, hypersomnia, and weight gain. Read More

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November 2018
4 Reads

A 48-Year-Old Athletic Man With Bradycardia During Sleep.

Chest 2018 Nov;154(5):e139-e142

Sleep Disorders Center, Neurologic Institute, Cleveland Clinic, Cleveland, OH.

Case Presentation: A 48-year-old athletic man with history of dyslipidemia and second-degree atrioventricular block (Mobitz type I 2:1 atrioventricular block) endorses sleep-related difficulties at his annual physical examination. Mobitz type I block was diagnosed 11 years earlier when the patient presented to his primary care physician with left-sided chest pain for 2 months. He was evaluated by cardiology, with a normal stress echocardiogram. Read More

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November 2018
5 Reads

[Diagnosis and comorbidities of Circadian Rhythm Sleep Disorders].

Presse Med 2018 Nov - Dec;47(11-12 Pt 1):969-976. Epub 2018 Nov 1.

Hôpital Civil, centre des troubles du sommeil-CIRCSom, département neurologique, 1, place de l'Hôpital, 67091 Strasbourg, France; Université de Strasbourg, institut des neurosciences cellulaires et intégratives, CNRS - UPR 3212, 5, rue Blaise-Pascal, 67000 Strasbourg, France.

Circadian rhythm sleep disorders (CRSD) result from a disturbed endogenous clock (intrinsic CRSD) or from a misalignment between the biological clock and an imposed environment (extrinsic CRSD). Among intrinsic CRSD, one distinguishes the delayed sleep-wake phase disorder, the advanced sleep-wake phase disorder, the irregular sleep-wake rhythm disorder and the non-24-hour sleep-wake rhythm disorder. Shift work disorder, jet lag disorder and circadian sleep-wake disorder not otherwise specified are extrinsic CRSD. Read More

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November 2018
11 Reads

Comparative Sleep Disturbances in Myotonic Dystrophy Types 1 and 2.

Curr Neurol Neurosci Rep 2018 Oct 31;18(12):102. Epub 2018 Oct 31.

System Medicine Department, University of Rome Tor Vergata, Rome, Italy.

Purpose Of Review: To update current knowledge regarding sleep disturbances and myotonic dystrophies so as to better understand if sleep symptoms may help in the early recognition of the two genetic subtypes: myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2).

Recent Findings: Sleep-disordered breathing (SDB), restless legs syndrome, periodic limb movements in sleep, hypersomnia, and REM sleep dysregulation are frequently described in DM1 patients. SDB does not always explain hypersomnia, but a central dysregulation of sleep-wake modulation is reported mainly in DM1. Read More

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October 2018
4 Reads

Solriamfetol for the treatment of daytime sleepiness in obstructive sleep apnea.

Expert Rev Respir Med 2018 Nov 2:1-13. Epub 2018 Nov 2.

a Department of Psychiatry & Behavioral Sciences, Division of Sleep Medicine , Stanford University , Redwood City , CA , USA.

Introduction: Obstructive sleep apnea (OSA) is highly prevalent and constitutes a major health hazard. Current pharmacotherapy is ineffective in correcting sleep-disordered breathing and is used adjunctively to address residual sleepiness. A new drug, solriamfetol, a selective norepinephrine-dopamine reuptake inhibitor, is the first drug of its class that is being considered by the US Food and Drug Administration (FDA) to treat excessive sleepiness in OSA and narcolepsy patients. Read More

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November 2018
15 Reads

Sleep disorders in traumatic brain injury.

NeuroRehabilitation 2018 ;43(3):257-266

Department of Neurology Northwestern University, Chicago, IL, USA.

Background: Sleep disorders play a significant role in the care of those with Traumatic Brain Injury (TBI).

Objective: To provide a literature review on the interaction of sleep and circadian processes on those with TBI.

Methods: A literature review was conducted on PubMed using the following key words and their combination: "Sleep Apnea", "Traumatic Brain Injury", "Circadian", "Parasomnia", "Insomnia", "Hypersomnia", "Narcolepsy", and "Restless Legs". Read More

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January 2018
6 Reads

Clinical Sleep-Wake Disorders I: Focus on Hypersomnias and Movement Disorders During Sleep.

Handb Exp Pharmacol 2018 Oct 20. Epub 2018 Oct 20.

Department of Neurology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.

Central disorders of hypersomnolence are characterized by daily periods of irrepressible need to sleep or daytime lapses into sleep, as defined in the current version of the International Criteria of Sleep Disorders. Thus, the unifying symptom is excessive daytime sleepiness which is not caused by any other sleep-wake disorder. Relevant disorders including narcolepsy type 1 and 2, idiopathic hypersomnia, Kleine-Levin syndrome, and insufficient sleep syndrome will be discussed. Read More

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October 2018
8 Reads

Efficacy of a mandibular advancement intraoral appliance (MOA) for the treatment of obstructive sleep apnea syndrome (OSAS) in pediatric patients: A pilot-study.

Med Oral Patol Oral Cir Bucal 2018 Nov 1;23(6):e656-e663. Epub 2018 Nov 1.

Av. Ipiranga, 6681, 90619-900 Porto Alegre RS, Brazil,

Background: To evaluate the treatment efficacy of a mandibular advancement intraoral appliance (MOA) for treatment of obstructive sleep apnea syndrome (OSAS) in pediatric patients.

Material And Methods: Eighteen patients (mean=8.39 years old, women=44. Read More

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November 2018
1 Read

[Narcolepsy and Other 'Central Disorders of Hypersomnolence'].

Authors:
Johannes Mathis

Praxis (Bern 1994) 2018;107(21):1161-1167

1 Universitäres Schlaf-Wach-Epilepsie Zentrum des Inselspitals Bern.

Narcolepsy and Other 'Central Disorders of Hypersomnolence' Abstract. 'Excessive daytime sleepiness', 'hypersomnia' in the sense of prolonged sleep need, 'tiredness' or 'fatigue' are frequent complaints in primary care, requiring a careful separation in view of a correct diagnostic. After exclusion of various internistic and neurologic causes by clinical and laboratory investigations and after exclusion of sleep apnoea syndrome or other causes of disturbed sleep by polysomnography, the ambiguous group of 'Central Disorders of Hypersomnolence' remains, including narcolepsy with and without cataplexy, idiopathic hypersomnia, and non-organic hypersomnia. Read More

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January 2018
1 Read

Hypertension and Atrial Fibrillation: What is the prevalence of obstructive sleep apnea syndrome?

Tunis Med 2018 Mar;96(3):187-192

Introduction: Obstructive sleep apnea-hypopnea syndrome (OSAS) and cardiovascular disease are public health problems. The objective of our study was to evaluate the frequency of OSAS in patients with hypertension and atrial fibrillation (AF) and to investigate the factors associated with OSAS in this population.

Methods: It's a cross-sectional study including 73patients with hypertension and AF. Read More

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March 2018
10 Reads

Sleep Disorders.

Am J Med 2018 Oct 4. Epub 2018 Oct 4.

Department of Neurology, Brigham and Women's Hospital, Boston, Mass.

Sleep disorders are frequent and can have serious consequences on patients' health and quality of life. While some sleep disorders are more challenging to treat, most can be easily managed with adequate interventions. We review the main diagnostic features of 6 major sleep disorders (insomnia, circadian rhythm disorders, sleep-disordered breathing, hypersomnia/narcolepsy, parasomnias, and restless legs syndrome/periodic limb movement disorder) to aid medical practitioners in screening and treating sleep disorders as part of clinical practice. Read More

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October 2018
3 Reads

Put to sleep by immune cells.

Authors:
Roland S Liblau

Nature 2018 10;562(7725):46-48

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October 2018
6 Reads

A variant at 9q34.11 is associated with HLA-DQB1*06:02 negative essential hypersomnia.

J Hum Genet 2018 Dec 28;63(12):1259-1267. Epub 2018 Sep 28.

Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Essential hypersomnia (EHS) is a lifelong disorder characterized by excessive daytime sleepiness without cataplexy. EHS is associated with human leukocyte antigen (HLA)-DQB1*06:02, similar to narcolepsy with cataplexy (narcolepsy). Previous studies suggest that DQB1*06:02-positive and -negative EHS are different in terms of their clinical features and follow different pathological pathways. Read More

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December 2018
10 Reads

A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice.

Proc Natl Acad Sci U S A 2018 10 25;115(41):10458-10463. Epub 2018 Sep 25.

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 305-8575 Tsukuba, Japan;

Sleep is an evolutionally conserved behavior from vertebrates to invertebrates. The molecular mechanisms that determine daily sleep amounts and the neuronal substrates for homeostatic sleep need remain unknown. Through a large-scale forward genetic screen of sleep behaviors in mice, we previously demonstrated that the mutant allele of the protein kinase gene markedly increases daily nonrapid-eye movement sleep (NREMS) amounts and sleep need. Read More

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October 2018
23 Reads

Olanzapine for the prevention and treatment of cancer-related nausea and vomiting in adults.

Cochrane Database Syst Rev 2018 09 21;9:CD012555. Epub 2018 Sep 21.

Katharine House Hospice, Mandeville Road, Aynho Road, Adderbury, Banbury, UK, OX17 3NL.

Background: Olanzapine as an antiemetic represents a new use of an antipsychotic drug. People with cancer may experience nausea and vomiting whilst receiving chemotherapy or radiotherapy, or whilst in the palliative phase of illness.

Objectives: To assess the efficacy and safety of olanzapine when used as an antiemetic in the prevention and treatment of nausea and vomiting related to cancer in adults. Read More

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September 2018
12 Reads

Effects of Upper Airway Surgery on Daytime Sleepiness in Nonobese Patients with Obstructive Sleep Apnea/Hypopnea Syndrome.

Ann Otol Rhinol Laryngol 2018 Dec 21;127(12):912-918. Epub 2018 Sep 21.

3 Sleep Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung City, Taiwan.

Introduction:: The aim of this study was to evaluate the effects of upper airway surgery on daytime sleepiness in nonobese patients with obstructive sleep apnea/hypopnea syndrome (OSA).

Methods:: This retrospective study included 121 consecutive adult nonobese patients with OSA from a tertiary academic medical center. Patients with OSA who refused continuous positive airway pressure therapy, or in whom it was unsuccessful, and then underwent OSA surgery were enrolled. Read More

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December 2018
4 Reads
1.050 Impact Factor

Hypersomnia.

Mo Med 2018 Jan-Feb;115(1):85-91

Pradeep Sahota, MD, MSMA member since 2003, in the Department of Neurology, University of Missouri - Columbia.

Adequate alertness is necessary for proper daytime functioning. Impairment of alertness or increase in sleepiness results in suboptimal performance and adversely affects the quality of life. While some causes of somnolence are intrinsic to the brain circuitry and neurochemical architecture, others are due to maladaptive behaviors and disorders affecting the normal sleep homeostasis. Read More

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September 2018

Impaired histaminergic neurotransmission in children with narcolepsy type 1.

CNS Neurosci Ther 2018 Sep 17. Epub 2018 Sep 17.

Integrative Physiology of the Brain Arousal System, CRNL, INSERM-U1028, CNRS, UMR5292, University Lyon1, Lyon, France.

Objective: Narcolepsy is a sleep disorder characterized in humans by excessive daytime sleepiness and cataplexy. Greater than fifty percent of narcoleptic patients have an onset of symptoms prior to the age of 18. Current general agreement considers the loss of hypothalamic hypocretin (orexin) neurons as the direct cause of narcolepsy notably cataplexy. Read More

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September 2018
4 Reads
3.930 Impact Factor

Milnacipran: serotonin-noradrenaline reuptake inhibitor approved for fibromyalgia may be a useful antidepressant.

Australas Psychiatry 2018 Oct 10;26(5):537-540. Epub 2018 Sep 10.

Pro-Vice Chancellor and Professor of Psychiatry, Monash University, Clayton, VIC, and; Professor of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.

Objective: Milnacipran is a serotonin noradrenaline reuptake inhibitor (SNRI) approved for treatment of fibromyalgia in Australia, but is used for depression in Europe and elsewhere. This paper will briefly review milnacipran and its utility in psychiatry for the treatment of depression.

Conclusion: Milnacipran is a dual reuptake inhibitor of noradrenaline and serotonin, with greater effect on noradrenaline than serotonin, in contrast to the related drugs venlafaxine, desvenlafaxine and duloxetine. Read More

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October 2018
11 Reads

HLA-DQB1*06:02 allele frequency and clinic-polysomnographic features in Saudi Arabian patients with narcolepsy.

Sleep Breath 2018 Sep 5. Epub 2018 Sep 5.

University Sleep Disorders Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: Narcolepsy is an uncommon neurological disorder characterised by irresistible spells of sleep associated with abnormal rapid eye movement (REM) sleep. The association between narcolepsy and human leukocyte antigen HLA- DQB1*06:02 has been established elsewhere but remains to be investigated among Saudi Arabian patients with narcolepsy.

Methods: A total of 29 Saudi patients with type I or type 2 narcolepsy comprising of 23 (79%) males and 6 (21%) females with a mean age of 17. Read More

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September 2018
2 Reads

Modafinil: its discovery, the early European and North American experience in the treatment of narcolepsy and idiopathic hypersomnia, and its subsequent use in other medical conditions.

Sleep Med 2018 Sep 6;49:69-72. Epub 2018 Jun 6.

Division of Neurology, Ottawa Hospital and University of Ottawa, Canada.

Adrafinil, a new molecule identified by a French drug company, L. Lafon Ltd, in 1974, was found to cause a significant dose-dependent increase in motor activity in mice, without exerting peripheral sympathomimetic effects. As early as 1977-78, Michel Jouvet prescribed adrafinil to narcoleptic patients, but without consistent results. Read More

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September 2018
3 Reads

Treatment of paediatric narcolepsy with sodium oxybate: a double-blind, placebo-controlled, randomised-withdrawal multicentre study and open-label investigation.

Lancet Child Adolesc Health 2018 Jul 21;2(7):483-494. Epub 2018 May 21.

Stanford Center for Sleep Sciences and Medicine, Palo Alto, CA, USA.

Background: Narcolepsy is a lifelong neurological disorder with onset commonly in childhood or adolescence. No drugs are indicated for cataplexy and excessive daytime sleepiness in paediatric patients with narcolepsy. Sodium oxybate is approved for use in adult patients with excessive daytime sleepiness or cataplexy, or both, in narcolepsy. Read More

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July 2018
1 Read

Lauflumide (NLS-4) Is a New Potent Wake-Promoting Compound.

Front Neurosci 2018 15;12:519. Epub 2018 Aug 15.

Faculty of Biology and Medicine, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

Psychostimulants are used for the treatment of excessive daytime sleepiness in a wide range of sleep disorders as well as in attention deficit hyperactivity disorder or cognitive impairment in neuropsychiatric disorders. Here, we tested in mice the wake-promoting properties of NLS-4 and its effects on the following sleep as compared with those of modafinil and vehicle. C57BL/6J mice were intraperitoneally injected with vehicle, NLS-4 (64 mg/kg), or modafinil (150 mg/kg) at light onset. Read More

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August 2018
12 Reads

Hypothalamic relapse of a cardiac large B-cell lymphoma presenting with memory loss, confabulation, alexia-agraphia, apathy, hypersomnia, appetite disturbances and diabetes insipidus.

BMJ Case Rep 2018 Aug 27;2018. Epub 2018 Aug 27.

Department of Medicine (Oncology), Houston Methodist Hospital, Houston, Texas, USA.

A 37-year-old Hispanic man with a right atrial intracardiac mass diagnosed as diffuse large B-cell lymphoma (DLBCL) was successfully treated with surgery and chemotherapy. During 4 years, several total-body positron emission tomography and MRI scans showed no extracardiac lymphoma. On year 5 after the cardiac surgery, patient presented with sleepiness, hyperphagia, memory loss, confabulation, dementia and diabetes insipidus. Read More

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August 2018
7 Reads

Michel Jouvet as a clinical neurophysiologist and neurologist.

Authors:
Hélène Bastuji

Sleep Med 2018 Sep 2;49:73-77. Epub 2018 Aug 2.

Central Integration of Pain (NeuroPain) Lab - Lyon Neuroscience Research Center; INSERM U1028; CNRS, UMR5292; Université Claude Bernard, Bron, France; Service de Neurologie Fonctionnelle et d'Épileptologie, Hôpital Neurologique, Hospices Civils de Lyon, France; Service de Médecine du Sommeil et des Maladies Respiratoires, Hôpital Croix-Rousse, Hospices Civils de Lyon, France. Electronic address:

While the world reputation of Michel Jouvet in sleep research is based on his huge work on sleep and paradoxical sleep, especially in cats, a far less-known part of his activity was dedicated to investigate and take care of patients with neurological diseases. Indeed, he was also a physician, specialized in neurophysiology and working at the neurological hospital of Lyon. He was most interested first in patients with disorders of consciousness and secondly in those with sleep/wake disorders, and especially in modafinil for the treatment of patients with narcolepsy and idiopathic hypersomnia. Read More

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September 2018
1 Read

Effects of a 10-week functional training programme on pain, mood state, depression, and sleep in healthy older adults.

Psychogeriatrics 2018 Jul;18(4):292-298

Department of Corporal Expression, University of Jaen, Jaen, Spain.

Background: The purpose of this study was to analyze the effects of a 10-week functional training (FT) programme on pain, mood state, sleep, and depression in healthy older adults.

Method: A group of 38 older adults (32 women, 6 men) voluntarily participated in this study. Participants were randomly assigned to either the experimental group (n = 20; age: 75. Read More

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July 2018
1 Read

Narcolepsy and adjuvanted pandemic influenza A (H1N1) 2009 vaccines - Multi-country assessment.

Vaccine 2018 10 16;36(41):6202-6211. Epub 2018 Aug 16.

Centers for Disease Control and Prevention (CDC), Immunization Safety Office, Atlanta, USA.

Background: In 2010, a safety signal was detected for narcolepsy following vaccination with Pandemrix, an AS03-adjuvanted monovalent pandemic H1N1 influenza (pH1N1) vaccine. To further assess a possible association and inform policy on future use of adjuvants, we conducted a multi-country study of narcolepsy and adjuvanted pH1N1 vaccines.

Methods: We used electronic health databases to conduct a dynamic retrospective cohort study to assess narcolepsy incidence rates (IR) before and during pH1N1 virus circulation, and after pH1N1 vaccination campaigns in Canada, Denmark, Spain, Sweden, Taiwan, the Netherlands, and the United Kingdom. Read More

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October 2018
18 Reads
3.624 Impact Factor

The brain-adipocyte-gut network: Linking obesity and depression subtypes.

Cogn Affect Behav Neurosci 2018 Dec;18(6):1121-1144

School of Medical Science, Griffith University Gold Coast, Southport, Australia.

Major depressive disorder (MDD) and obesity are dominant and inter-related health burdens. Obesity is a risk factor for MDD, and there is evidence MDD increases risk of obesity. However, description of a bidirectional relationship between obesity and MDD is misleading, as closer examination reveals distinct unidirectional relationships in MDD subtypes. Read More

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December 2018
2 Reads

Circulating follicular helper T cells exhibit reduced ICOS expression and impaired function in narcolepsy type 1 patients.

J Autoimmun 2018 Nov 6;94:134-142. Epub 2018 Aug 6.

INSERM U1043, CNRS UMR, 5282, Toulouse III University, Center for Pathophysiology Toulouse Purpan, Toulouse, France; Department of Immunology, Toulouse University Hospitals, Toulouse, France. Electronic address:

Despite genetic and epidemiological evidence strongly supporting an autoimmune basis for narcolepsy type 1, the mechanisms involved have remained largely unknown. Here, we aimed to investigate whether the frequency and function of circulating follicular helper and follicular regulatory T cells are altered in narcolepsy type 1. Peripheral blood mononuclear cells were collected from 32 patients with narcolepsy type 1, including 11 who developed disease after Pandemrix vaccination, and 32 age-, sex-, and HLA-DQB1*06:02-matched healthy individuals. Read More

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November 2018
10 Reads

Fluctuating CSF hypocretin-1 levels in mild brain trauma-induced Kleine-Levin syndrome.

J Neurol Sci 2018 Aug 17;391:10-11. Epub 2018 May 17.

Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.

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The influence of socio-economic status on the severity of obstructive sleep apnea: a cross-sectional observational study.

Sleep Sci 2018 Mar-Apr;11(2):92-98

"Sismanoglio" General Hospital of Attica, Respiratory Function & Sleep Study Unit - Marousi - Attica - Grécia.

There is limited evidence about the effect of socio-economic status (SES) on the severity of obstructive sleep apnea (OSA). We aimed to investigate this relationship in a referral population in Greece, with regards to other established risk factors. We used a retrospective cross-sectional design to assess socio-economic status based on occupational activity in a sample of 282 OSA patients diagnosed in a public hospital sleep laboratory during one-year period. Read More

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August 2018
1 Read

Sleep profiles and CBT-I response in schizophrenia and related psychoses.

Psychiatry Res 2018 Oct 24;268:279-287. Epub 2018 Jul 24.

Clinical Research Centre, North Metropolitan Health Service Mental Health, Perth, Australia; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia.

This study investigated sleep subtypes in schizophrenia, and their response to Cognitive Behavioural Therapy for Insomnia (CBT-I) treatment. Sleep profiling was conducted using latent class analysis on baseline Pittsburgh Sleep Quality Index data (N = 74 outpatients with schizophrenia who were poor sleepers, 52% male, mean age = 41.4 years). Read More

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October 2018

Distinguishing the efficacy and sedative effects of guanfacine extended release in children and adolescents with attention-deficit/hyperactivity disorder.

Eur Neuropsychopharmacol 2018 Jul 29. Epub 2018 Jul 29.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

The present study investigated whether symptom reduction in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) treated with guanfacine extended release (GXR) can be explained by sedative effects of the medication. Data from four double-blind, randomized, placebo-controlled, phase 3 trials of GXR monotherapy (1-7 mg/day; morning administration) in children (aged 6-12 years) and adolescents (aged 13-17 years) with ADHD were analyzed post hoc. Two studies used forced-dose titration and two used flexible-dose titration. Read More

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July 2018
1 Read

[Studies of narcolepsy in Russia. Historical view].

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(4. Vyp. 2):129-138

Sechenov First Moscow Medical University, Moscow, Russia.

Narcolepsy is a hardly known and obscure disease for Russian doctors while the first description and studying of the disease in Russia occurred almost simultaneously with the rest of the world. The contribution of Russian neurology in the studying of narcolepsy remains underestimated, especially in identifying the clinical features (A. Vein's 'narcoleptic pentad'), the concept of the pathogenesis (hypothalamic syndrome), the determination of provoking factors (postinfectious, postvaccinal reacions) and the use of effective medications (sodium oxybate). Read More

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January 2018
2 Reads

French consensus: Augmentation syndrome in restless legs syndrome.

Rev Neurol (Paris) 2018 Sep - Oct;174(7-8):532-539. Epub 2018 Jul 25.

Narcolepsy and Idiopathic Hypersomnia National Reference Centre, 75000 Paris, France; Neurology Department, Sleep disorders Unit, Gui-De-Chauliac Hospital, 34295 Montpellier, France; Inserm U1061, UM1, 34295 Montpellier, France.

Augmentation syndrome is one of the most severe complications of RLS. It is characterised by a worsening of treated symptoms; principally an increase in the severity of symptoms and an earlier onset time. Augmentation syndrome occurs primarily with dopaminergic treatments. Read More

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July 2018
1 Read

Bilateral Thalamic Ischemic Stroke Secondary to Occlusion of the Artery of Percheron.

Cureus 2018 May 23;10(5):e2676. Epub 2018 May 23.

Neurology, Hospital General De Tijuana, Tijuana, MEX.

The occlusion of the artery of Percheron (AOP) is a rare condition that causes bilateral thalamic ischemic stroke with or without midbrain involvement. It happens as a result of an anatomical variant of the diencephalic irrigation, in which the thalamic paramedian arteries arise from a common trunk from the posterior cerebral artery (PCA), which generates a clinical syndrome characterized by bilateral vertical gaze palsy, memory impairment and hypersomnia. In this case, we report a 62-year-old woman admitted to the emergency room with altered mental status, mainly somnolence. Read More

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May 2018
12 Reads

Case report: narcolepsy type 1 in an adolescent with HIV infection-coincidence or potential trigger?

Medicine (Baltimore) 2018 Jul;97(30):e11490

Division of Infectious Diseases and Hospital Epidemiology and Children's Research Center University Children's Hospital Zurich, Zürich, Switzerland.

Rationale: Despite the acknowledged importance of environmental risk factors in the etiology of narcolepsy, there is little research on this topic. HIV as a trigger for narcolepsy has not been systematically investigated.

Patient Concerns: We describe a case of narcolepsy type 1 (NT1) in an adolescent with HIV infection presenting with increased daytime sleepiness and excessive weight gain. Read More

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July 2018
2 Reads

Sleep Disturbance in Children With Moderate or Severe Traumatic Brain Injury Compared With Children With Orthopedic Injury.

J Head Trauma Rehabil 2018 Jul 24. Epub 2018 Jul 24.

School of Psychology (Drs Bogdanov and Lah) and Brain and Mind Centre and Charles Perkins Centre (Dr Naismith), University of Sydney, Camperdown, Australia; Rehab2Kids Rehabilitation Unit (Ms Brookes and Dr Epps) and Department of Sleep Medicine (Dr Teng), Sydney Children's Hospital, Randwick, Australia; School of Paediatrics and Women's Health, University of New South Wales, Kensington, Australia (Dr Teng); and ARC Centre of Excellence in Cognition and Its Disorders, Macquarie University, North Ryde, Australia (Dr Lah).

Objectives: To characterize the sleep disturbance in children with moderate or severe traumatic brain injury (TBI), and to identify associated factors.

Setting: An urban tertiary pediatric healthcare facility.

Participants: Children aged 5 to 15 years with a moderate TBI (n = 21), severe TBI (n = 23), or an orthopedic injury (OI; n = 38) comparable in age, gender, and socioeconomic status. Read More

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July 2018
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Prevalence of seasonal depression in a prospective cohort study.

Eur Arch Psychiatry Clin Neurosci 2018 Jul 18. Epub 2018 Jul 18.

Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.

The prevalence of autumn/winter seasonality in depression has been documented in the longitudinal Zurich cohort study by five comprehensive diagnostic interviews at intervals over more than 20 years (N = 499). Repeated winter major depressive episodes (MDE-unipolar + bipolar) showed a prevalence of 3.44% (5× more women than men), whereas MDE with a single winter episode was much higher (9. Read More

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July 2018
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Apnoeic and Hypopnoeic Load in Obstructive Sleep Apnoea: Correlation with Epworth Sleepiness Scale.

Ann Acad Med Singapore 2018 Jun;47(6):216-222

Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Introduction: Patients with obstructive sleep apnoea (OSA) often present with excessive daytime sleepiness (EDS) as measured by the Epworth Sleepiness Scale (ESS). However, the relationship between EDS and OSA severity as measured by the apnoea-hypopnoea index (AHI) remains inconsistent. We hypothesise that this may be due to the usage and equal weightage of apnoea and hypopnoea events used in determining AHI and that apnoea and hypopnoea load as measured by their total durations may be a better metric to use. Read More

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