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    Cutaneous Leukocytoclastic Vasculitis Following Influenza Vaccination in Older Adults: Report of Bullous Purpura in an Octogenarian after Influenza Vaccine Administration.
    Cureus 2018 Mar 14;10(3):e2323. Epub 2018 Mar 14.
    Department of Dermatology, University of California, San Diego.
    The influenza vaccination is recommended annually for protection against influenza infection. Adults over 65 years of age are especially vulnerable to complications from influenza infection; in addition, they constitute the largest group of influenza vaccination recipients each year. Cutaneous leukocytoclastic vasculitis involves inflammation of small vessel walls by neutrophils. Read More

    Hemorrhagic bullous lesions in Henoch-Schönlein purpura: a case report and review of the literature.
    BMC Pediatr 2018 May 10;18(1):157. Epub 2018 May 10.
    Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics, Kaohsiung Veterans General Hospital, No. 386, Dazhong 1st Road, Zuoying District, Kaohsiung City, 813, Taiwan.
    Background: Henoch-Schönlein purpura (HSP) is a common vasculitis in childhood characterized by purpura, arthritis, abdominal pain and renal involvement. However, bullous HSP is a rare cutaneous manifestation, and a few cases have been reported.

    Case Presentation: Herein, we report a 15-year-old male with bullous HSP who presented with severe abdominal pain and hemorrhagic bullous lesions over his lower extremities. Read More

    Complex Regional Pain Syndrome: What the Dermatologist Should Know.
    J Drugs Dermatol 2018 May;17(5):532-536
    Reflex sympathetic dystrophy is a subtype of complex regional pain syndrome, a condition characterized by persistent post-injury extremity pain. Temperature and sweating changes, edema, mobility changes, and a variety of hair, nail, and skin sequelae have been described. Only 23 articles published since 1990 describe dermatologic changes in CRPS. Read More

    A Case Report and Literature Review of Scrub Typhus With Acute Abdomen and Septic Shock in a Child-The Role of Leukocytoclastic Vasculitis and Granulysin.
    Am J Dermatopathol 2018 Apr 24. Epub 2018 Apr 24.
    Department of Dermatology, Chang Gung Memorial Hospital, Linko, Taipei, Taiwan.
    Scrub typhus is becoming a clinically important cause of acute undifferentiated febrile illness in Taiwan. The incubation period is between 6 and 21 days after exposure. It is transmitted by chiggers (larva of trombiculid mite) in long grasses and in dirt-floor homes, with infection characterized by a flu-like illness of fever, headache, and myalgia lasting approximately 1 week. Read More

    Cutaneous Vasculitis and Recurrent Infection Caused by Deficiency in Complement Factor I.
    Front Immunol 2018 11;9:735. Epub 2018 Apr 11.
    Infection Inflammation and Rheumatology Section, Great Ormond Street Institute of Child Health, University College London, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.
    Cutaneous leukocytoclastic vasculitis arises from immune complex deposition and dysregulated complement activation in small blood vessels. There are many causes, including dysregulated host response to infection, drug reactions, and various autoimmune conditions. It is increasingly recognised that some monogenic autoinflammatory diseases cause vasculitis, although genetic causes of vasculitis are extremely rare. Read More

    [MALT lymphoma with t (X;14) (p11.2;q32) developing during the course of cutaneous leukocytoclastic angitis].
    Rinsho Ketsueki 2018 ;59(3):269-274
    Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine.
    A 73-year-old man with left parotid gland swelling over 2 months was referred to our hospital in March 201X. Purpura on the lower legs had been recurrent for >20 years. Biopsy of the parotid gland demonstrated diffuse infiltration of abnormal lymphocytes that were negative for CD10 and positive for CD19, CD20, and κ-chain. Read More

    Histopathology of Cutaneous Inflammatory Disorders in Children.
    Pediatr Dev Pathol 2018 Mar-Apr;21(2):115-149
    1 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
    Inflammatory dermatoses encompass a variety of histologic patterns that affect different portions of the skin. In spongiotic, psoriasiform, lichenoid, pityriasiform, and blistering disorders, there are predominately epidermal and junctional activities with variable superficial dermal inflammation. Hypersensitivity reactions can show either epidermal or mostly dermal changes depending on whether the exposure of the exogenous allergen occurs through an external or internal route, respectively. Read More

    Five Hundred Fifty-five Retrieved Metal-on-metal Hip Replacements of a Single Design Show a Wide Range of Wear, Surface Features, and Histopathologic Reactions.
    Clin Orthop Relat Res 2018 Feb;476(2):261-278
    S.-H. Park, Z. Lu, P. A. Campbell, E. Ebramzadeh, The J. Vernon Luck, Sr, MD Orthopaedic Research Center, Orthopaedic Institute for Children and UCLA Department of Orthopaedic Surgery, Los Angeles, CA, USA R. S. Hastings, DePuy, Inc, Warsaw, IN, USA.
    Background: In 2010, a widely used metal-on-metal hip implant design was voluntarily recalled by the manufacturer because of higher than anticipated failure rates at 5 years. Although there was a large published range of revision rates, numerous studies had reported a higher risk of revision for excessive wear and associated adverse tissue reactions when compared with other metal-on-metal total hips. The reasons for this were suggested by some to be related to cup design features. Read More

    The clinical characteristics and the features of immunophenotype of peripheral lymphocytes of adult onset chronic active Epstein-Barr virus disease at a Tertiary Care Hospital in Beijing.
    Medicine (Baltimore) 2018 Mar;97(9):e9854
    Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
    Chronic active Epstein-Barr virus (CAEBV) infection is a rare disease with high mortality. Most of CAEBV patients have been reported from Japan and are pediatric cases.The goal was to describe the clinical characteristics and the immunophenotypic features of peripheral lymphocytes in adult onset CAEBV patients. Read More

    HEMORRHAGIC OCCLUSIVE RETINAL VASCULITIS AFTER INTRACAMERAL VANCOMYCIN USE IN CATARACT SURGERY AFTER INTRAVENOUS EXPOSURE.
    Retin Cases Brief Rep 2018 Feb 22. Epub 2018 Feb 22.
    Department of Ophthalmology, Yale University, New Haven, Connecticut.
    Purpose: To report a case of hemorrhagic occlusive retinal vasculitis after cataract surgery.

    Methods: A 74-year-old woman presented with blurry vision and distorted vision, which started 2 days after an uncomplicated cataract surgery in the left eye. Intracameral vancomycin was injected during the case. Read More

    Henoch-Schönlein purpura in the third trimester of pregnancy.
    Biochem Med (Zagreb) 2018 Feb 10;28(1):010801. Epub 2018 Jan 10.
    Clinical Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
    Henoch-Schönlein purpura (HSP) is an IgA-mediated small vessels' vasculitis that affects the skin, intestines and kidneys. Pregnancy has been reported as an exacerbating factor. We present the case of a 24-year-old with HSP that occurred in the third trimester and lasted up to the end of the successful delivery. Read More

    Complete resolution of erythema elevatum diutinum using oral sulfasalazine.
    Dermatol Online J 2017 Oct 15;23(10). Epub 2017 Oct 15.
    Harvard University, Cambridge, Massachusetts, Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts. michael_
    Erythema elevatum diutinum (EED) is a rare, chronic small-vessel vasculitis that presents as firm, red, violaceous, or brown papules and nodules on the extensor surfaces of the limbs. Oral dapsone is considered first-line therapy for EED; in the current case report, a patient presenting with EED began dapsone treatment and symptoms subsided within two weeks. Seven months later, the patient became pregnant and stopped dapsone owing to her concerns with dapsone use during pregnancy, resulting in recurrence of EED symptoms. Read More

    A case of probable trimethoprim-sulfamethoxazole induced circulating antineutrophil cytoplasmic antibody-positive small vessel vasculitis.
    Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.
    Department of Dermatology, University of Illinois College of Medicine at Peoria, Peoria, Illinois.
    Cutaneous leukocytoclastic vasculitis (LCV) can occur as skin-limited disease or as part a systemic vasculitis. Appropriate workup includes the evaluation of antineutrophil cytoplasmic antibodies (ANCAs), with a positive titer raising concern for the associated primary vasculitides including microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), or eosinophilic granulomatosis with polyangiitis (EGPA). In the absence of systemic findings, however, a drug etiology must also be considered. Read More

    A case of leukocytoclastic vasculitis caused by novel anticoagulant rivaroxaban.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    McGovern Medical School, Houston, Texas.
    Cutaneous leukocytoclastic vasculitis (LCV) is type of small vessel vasculitis that commonly presents as palpable purpura involving the lower extremities and buttocks. Approximately half of cases are idiopathic, but the disease may be triggered by infection, drug reaction, inflammatory disease, or other causes. We report a case of leukocytoclastic vasculitis secondary to the novel anticoagulant rivaroxaban (Xarelto®). Read More

    Propylthiouracil-induced ANCA-negative cutaneous small vessel vasculitis.
    J Community Hosp Intern Med Perspect 2018 6;8(1):35-37. Epub 2018 Feb 6.
    Department of Medicine/Division of Rheumatology, University of Tennessee College of Medicine, Chattanooga, TN, USA.
    Propylthiouracil (PTU) is a commonly used medication for the treatment of hyperthyroidism. PTU is known to cause different adverse reactions including autoimmune syndromes. PTU-induced autoimmune syndromes can be classified into drug-induced lupus or drug-induced vasculitis. Read More

    Pazopanib-Induced Cutaneous Leukocytoclastic Vasculitis: An Exclusion Diagnosis of a Multidisciplinary Approach.
    Case Rep Oncol 2017 Sep-Dec;10(3):1041-1049. Epub 2017 Nov 27.
    Dermatology Department, Instituto CUF de Oncologia (I.C.O.), Lisbon, Portugal.
    In phase II/III trials, cutaneous side effects of pazopanib were reported in less than 20% of patients, with only 1-3% being grade 3/4. We present a case of a 66-year-old man with a previous history of left nephrectomy for a stage II clear cell renal carcinoma. Approximately 18 months later, recurrent disease in the lungs, mediastinum, and left psoas and bulky abdominal/pelvic nodal metastasis were documented. Read More

    Non-hemorrhage-related adverse effects of rivaroxaban.
    Arch Med Sci Atheroscler Dis 2017 31;2:e108-e112. Epub 2017 Dec 31.
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.
    The direct oral anticoagulant rivaroxaban is useful in various indications that include venous deep vein thrombosis prophylaxis/treatment after knee/hip replacement surgery and prevention of stroke in patients with non-valvular atrial fibrillation. Its mechanism of action has been mostly associated with hemorrhage-related adverse effects; thus a number of non-hemorrhage-related adverse effects of the drug have received less attention or go unrecognized. These adverse effects mainly include liver injury, hypersensitivity reactions, leukocytoclastic vasculitis and hair loss. Read More

    Cutaneous and systemic vasculitides in dermatology: a histological perspective.
    G Ital Dermatol Venereol 2018 Apr 24;153(2):185-193. Epub 2018 Jan 24.
    Unit of Dermatology, IRCCS Ca' Granda Foundation, Ospedale Maggiore Policlinico, Milan, Italy.
    Cutaneous vasculitides encompass a wide and heterogeneous group of diseases affecting skin blood vessels that are clinically characterized by polymorphic skin lesions, particularly including palpable purpura as well as urticarial and necrotic-ulcerative lesions, with possible, albeit rare, extracutaneous involvement. Cutaneous leukocytoclastic angiitis and urticarial vasculitis, which are the two prototypic and most common variants of this group, are usually idiopathic but may also be induced by different triggers, notably drugs and infections, or may manifest in association with systemic disorders, particularly lupus erythematosus. Vasculitis skin lesions can also occur during the chronic-relapsing course of systemic vasculitides, such as granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis, with which cutaneous vasculitides can share clinical and histological features. Read More

    Cutaneous hemophagocytosis: Clinicopathologic features of 21 cases.
    J Am Acad Dermatol 2018 Feb;78(2):377-382
    Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria. Electronic address:
    Background: Hemophagocytosis is well known in cytotoxic cutaneous T-cell lymphomas (CTCLs), in which it may represent a sign of hemophagocytic lymphohistiocytosis syndrome (HLHS), and is also typical of cutaneous Rosai-Dorfman disease (cRDD) (without prognostic relevance). Only rarely, has cutaneous hemophagocytosis (CH) been described in other skin conditions.

    Objective: To characterize the clinicopathologic features of CH in skin biopsy specimens from patients with conditions other than CTCL or cRDD. Read More

    Retinal vasculitis associated with cutaneous leukocytoclastic vasculitis.
    Int Ophthalmol 2017 Dec 18. Epub 2017 Dec 18.
    Dalmia Ophthalmic Pathology Services, L V Prasad Eye Institute, Bhubaneswar, India.
    Introduction: To report a case of retinal vasculitis associated with cutaneous leukocytoclastic vasculitis.

    Methods: Retrospective chart review.

    Results: A 28-year-old man, who initially presented with occlusive retinal vasculitis and vitreous hemorrhage in right eye that resolved with sectoral photocoagulation. Read More

    Leukocytoclastic vasculitis complicating cisplatin + radiation treatment for laryngeal cancer: a case report.
    BMC Cancer 2017 12 6;17(1):831. Epub 2017 Dec 6.
    School of Medical Sciences (FCM), University of Campinas (UNICAMP), 126 Tessália Vieira de Camargo Street, Campinas, SP, 13083-8871, Brazil.
    Background: Leukocytoclastic vasculitis is typically mediated by deposition of immune complexes and is related to many causes, including medication. To the best of our knowledge, leukocytoclastic vasculitis related to cisplatin has not yet been described in the scientific literature.

    Case Presentation: We report a rare case of leukocytoclastic vasculitis after the first cycle of high-dose cisplatin chemotherapy in a patient with larynx carcinoma. Read More

    Vasculitis: Kids are not just little people.
    Clin Dermatol 2017 Nov - Dec;35(6):530-540. Epub 2017 Aug 4.
    Department of Dermatology Lahey Clinic, Burlington, MA.
    Cutaneous vasculitis, inflammatory destruction of blood vessels, can present with a wide range of clinical and pathologic findings across a number of heterogeneous conditions. Although some vasculitides are present in both children and adults, some important differences exist in clinical presentation, etiology, management, and prognosis in childhood vasculitis versus adult vasculitis. Cutaneous vasculitis is rare in children, and most childhood vasculitides, of which Henoch-Schönlein purpura is the most common, histologically are small vessel leukocytoclastic vasculitis. Read More

    Dapsone treatment is efficient against persistent cutaneous and gastrointestinal symptoms in children with Henoch-Schönlein purpura.
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2017 Nov 2. Epub 2017 Nov 2.
    Department of Pediatrics, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic.
    Background: Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis involving the capillaries and by the deposition of IgA immune complexes. An association between HSP and atypical bacteria is uncommon in children.

    Methods And Results: Here we report three cases of children, aged 5, 4 and 16 years, who were diagnosed with HSP associated with Mycoplasma pneumoniae or Chlamydia pneumoniae infection. Read More

    [Acute hemorrhagic edema of infancy: alarming lesions of a benign condition. Case report].
    Arch Argent Pediatr 2017 12;115(6):e432-e435
    Salud total EPS, Urbanización El Bosque.
    We report a case of acute hemorrhagic edema of infancy in an 18-month-old boy after an episode of otitis media. The clinical presentation begins with skin erythematous macules on the thighs, followed by purpuric lesions in arms, legs, and ankle edema. It was initially interpreted as urticaria, whereby steroids were indicated. Read More

    Leukocytoclastic vasculitis presenting in association with Coxiella burnetii (Q fever): A case report.
    J Cutan Pathol 2018 Jan 20;45(1):71-73. Epub 2017 Nov 20.
    Department of Pathology and Dermatopathology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California.
    Q fever caused by Coxiella burnetii usually presents asymptomatically or as an undifferentiated febrile disease and rarely as rash or other cutaneous manifestations of the disease. Here we present a 41-year-old male complaining of body ache, fever, nausea, malaise, bilateral knee pain and vomiting. Clinical examination revealed a notable erythematous blanching rash all over his body. Read More

    Direct immunofluorescence testing in vasculitis-A single institution experience with Henoch-Schönlein purpura.
    J Cutan Pathol 2018 Jan 8;45(1):16-22. Epub 2017 Nov 8.
    Departments of Pathology and Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio.
    Background: Direct immunofluorescence (DIF) panels (IgG, IgA, IgM, C3 and fibrinogen) are ordered for clinically suspected vasculitis, with frequently negative results.

    Methods: Cases submitted for DIF and histology (2010-2014) with "vasculitis" in the clinical data were examined, and the electronic medical record reviewed for clinical suspicion of Henoch-Schönlein purpura (HSP). Peri/intravascular IgA was considered positive, other reactants non-specific and no immunoreactivity negative. Read More

    Outline of guidelines for the management of vasculitis and vascular disorders in Japan, 2016 revised edition.
    J Dermatol 2018 Feb 6;45(2):122-127. Epub 2017 Oct 6.
    Department of Dermatology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
    The proposal by the 1994 International Chapel Hill Consensus Conference on the Nomenclature of Systemic Vasculitides (CHCC1994) and by the CHCC2012 markedly influenced the classification and way of considering cutaneous vasculitis. In the proposal by the CHCC1994, hypersensitivity angiitis was defined as an equivalent pathological condition to microscopic polyangiitis or cutaneous leukocytoclastic angiitis (CLA), and it was not adopted as a disease name. However, CLA which was positioned as a type of small-vessel vasculitis is only a pathological name. Read More

    Cutaneous leukocytoclastic vasculitis: the role of lymphocytes and related immune markers.
    Postepy Dermatol Alergol 2017 Aug 1;34(4):299-305. Epub 2017 Aug 1.
    Department of Dermatology, Ruhr-University Bochum, Bochum, Germany.
    Introduction: Apart from neutrophils, other immune cells may play a significant pathogenetic role in cutaneous leukocytoclastic vasculitis (CLV).

    Aim: To investigate lymphocytes and related immunological factors in patients with CLV requiring systemic glucocorticosteroid treatment.

    Material And Methods: Fourteen patients with severe idiopathic CLV were treated with systemic prednisolone in a tapered dose regimen. Read More

    Vancomycin-Induced Leukocytoclastic Vasculitis and Acute Renal Failure Due to Tubulointerstitial Nephritis.
    Am J Case Rep 2017 Sep 25;18:1024-1027. Epub 2017 Sep 25.
    Department of Infectious Diseases, Marshfield Clinic, Sacred Heart Hospital, Eau Claire, WI, USA.
    BACKGROUND Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and sepsis are commonly treated with intravenous vancomycin. However, vancomycin treatment is associated adverse reactions, including skin rashes and nephrotoxicity. We present a case of acute renal failure due to acute tubulointerstitial nephritis associated with a diffuse leukocytoclastic vasculitic skin eruption following intravenous vancomycin treatment. Read More

    Bacterial Endocarditis Presenting as Leukocytoclastic Vasculitis.
    Cureus 2017 Jul 13;9(7):e1464. Epub 2017 Jul 13.
    Internal medicine/ Rheumatology, Arthritis and Rheumatology Clinics of Kansas.
    Subacute bacterial endocarditis can have many different presentations; in rare instances, it can present as leukocytoclastic vasculitis owing to the effect of circulating immune complexes and micro-emboli on the vascular endothelium. A high index of suspicion needs to be maintained to differentiate between infectious vs noninfectious autoimmune vasculitides, keeping in mind that missing a diagnosis can have fatal results. In this case report, we introduce a young female patient who initially presented with a picture of idiopathic autoimmune cutaneous vasculitis delaying the diagnosis of an underlying infective endocarditis with aortic valve involvement. Read More

    Liver chemistry in new-onset Henoch-Schönlein syndrome.
    Ital J Pediatr 2017 Sep 21;43(1):85. Epub 2017 Sep 21.
    Pediatric Emergency Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
    Background: Henoch-Schönlein syndrome is a systemic small-vessel leukocytoclastic vasculitis that usually present with cutaneous, gastrointestinal, articular and renal manifestations. Little is known on liver involvement in this syndrome. This study investigated liver chemistry and creatine kinase in Henoch-Schönlein children. Read More

    Pediatric vasculitis: a single center experience.
    Int J Dermatol 2017 Nov 19;56(11):1130-1138. Epub 2017 Sep 19.
    First Department of Pediatrics, University of Athens, Aghia Sofia Children's Hospital, Athens, Greece.
    Background: Existing studies of children with vasculitis are limited. The aim of this study was to assess the epidemiology, clinical manifestations, laboratory findings, course, and outcome of Greek children presenting with vasculitic rash.

    Methods: The relevant data included in the study were collected retrospectively using a standardized form from children who were admitted into our department between 2003 and 2013, with the provisional diagnosis of vasculitis of the skin. Read More

    Protective Role of Mast Cells in Primary Systemic Vasculitis: A Perspective.
    Front Immunol 2017 23;8:990. Epub 2017 Aug 23.
    Division of Allergy, Clinical Immunology and Rheumatology, Department of Medicine, University of Kansas Medical Center, Kansas City, KS, United States.
    Mast cells are important cells of the immune system. Although traditionally considered as key players in allergic and hypersensitivity reactions, emerging evidence suggests that mast cells have many complex roles in vascular disease. These include regulation of vasodilation, angiogenesis, activation of matrix metalloproteinases, apoptosis of smooth muscle cells, and activation of the renin angiotensin system. Read More

    Cutaneous Manifestations of Small-Vessel Leukocytoclastic Vasculitides in Childhood.
    Clin Rev Allergy Immunol 2017 Dec;53(3):439-451
    Pediatric Department of Southern Switzerland, San Giovanni Hospital, 6500, Bellinzona, Switzerland.
    In childhood, cutaneous small-vessel vasculitides include Henoch-Schönlein syndrome, a systemic vasculitis, and Finkelstein-Seidlmayer syndrome, a skin-limited vasculitis. Both Henoch-Schönlein and Finkelstein-Seidlmayer syndromes are seen more frequently in white or Asian compared with black children and occur especially in winter and spring with a male-to-female ratio of approximately 2:1. In everyday clinical practice, both conditions are diagnosed on clinical grounds without histological confirmation. Read More

    Henoch-Schonlein purpura associated with primary active Epstein-Barr virus infection: a case report.
    Pan Afr Med J 2017 11;27:29. Epub 2017 May 11.
    University of Health Sciences, Umraniye Research and Training Hospital, Department of Pediatrics, Istanbul, Turkey.
    Henoch-Schönlein purpura (HSP) is the most common form of childhood vasculitis. Various viral and bacterial infections, drugs, vaccines, food allergy and even insect bites have been considered as triggering factors in pathogenesis of HSP. Epstein-Barr virus (EBV) infection, which is associated with HSP, have been rarely reported. Read More

    Leukocytoclastic Vasculitis and Dermal Perivascular Hemophagocytosis Associated With Adalimumab Therapy for Rheumatoid Arthritis.
    Am J Dermatopathol 2018 Jan;40(1):57-59
    Departments of Dermatology, and.
    Tumor necrosis factor (TNF)-α inhibitors target TNF-α to effectively treat autoimmune inflammatory conditions, such as rheumatoid arthritis. However, many cases of cutaneous and systemic vasculitis related to TNF-α inhibitors have been reported in the literature. Here, the authors report the first case of a 61-year-old Japanese woman who developed leukocytoclastic vasculitis with cutaneous perivascular hemophagocytosis, which was related to elevated cytokines and immune complexes after initiating adalimumab for rheumatoid arthritis without evidence of hemophagocytic syndrome and rarely encountered in the skin. Read More

    Leucocytoclastic vasculitis following influenza vaccination.
    BMJ Case Rep 2017 Jul 14;2017. Epub 2017 Jul 14.
    Department of Internal Medicine, Western University, London, Ontario, Canada.
    Background: Influenza vaccinations are commonly administered and effectively prevent influenza. Most vaccine reactions are mild and self-limiting with few reported cases of vasculitis. We present a case of vasculitis post-vaccination unique for its dramatic visual presentation and rapid response to treatment with the aim to emphasise possible causation and timely treatment. Read More

    Making Sense of Metal Allergy and Hypersensitivity to Metallic Implants in Relation to Hand Surgery.
    J Hand Surg Am 2017 Sep 12;42(9):737-746. Epub 2017 Jul 12.
    Department of Orthopedic Surgery, Division of Hand Surgery, Mayo Clinic, Rochester, MN. Electronic address:
    All metals implanted into a biological system undergo some degree of corrosion depending upon its composition. The electrochemical process of corrosion produces free metal ions, which may activate the host's immune system through a variety of mechanisms. Whereas dermal metal hypersensitivity is common, affecting 10% to 15% of the population, the immune reaction from implanted metals is much less common (< 0. Read More

    Possible role of Helicobacter pylori in diseases of dermatological interest.
    J Biol Regul Homeost Agents 2017 APR-JUN;31(2 Suppl. 2):57-77
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

    Leukocytoclastic vasculitis resolution with topical dapsone.
    Cutis 2017 Jun;99(6):426-428
    Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
    Leukocytoclastic vasculitis (LCV) is a disease characterized by inflammation of small vessels presenting with petechiae and palpable purpura. Leukocytoclastic vasculitis often spontaneously resolves within weeks and requires only symptomatic treatment. Chronic or severe disease can require systemic treatment with agents such as colchicine, dapsone, or corticosteroids, which are effective but carry a risk for serious adverse events. Read More

    Vesiculobullous variant of erythema elevatum diutinum.
    Clin Exp Dermatol 2017 Oct 22;42(7):777-780. Epub 2017 Jun 22.
    Unidad de Gestión Clínica Dermatología y Venereología, Hospital Universitario Puerta del Mar, Cádiz, Spain.
    The vesiculobullous variant of erythema elevatum diutinum (EED) is a very rare variant of EED. We describe a 16-year-old boy who presented with symmetrical nodular lesions accompanied by vesicles on the dorsa of his hands. Biopsy findings were consistent with EED. Read More

    Cocaine-Levamisole-Induced Vasculitis/Vasculopathy Syndrome.
    Curr Rheumatol Rep 2017 Jun;19(6):36
    Hospital Pablo Tobon Uribe, Calle 78 B # 69-240 consultorio 153, Medellin, Colombia.
    Purpose Of Review: To understand the clinical spectrum of cocaine-levamisole-induced vasculitis. Worldwide recreational drug consumption is high among the adult population from various social strata. The use of cocaine with levamisole, a frequently added antiparasitic diluent, favors the manifestations of vasculitic lesions, especially in the skin. Read More

    [Granulomatous reaction pattern of the skin : Interstitial granulomatous dermatitis - lymphoma - vasculitis].
    Hautarzt 2017 Jul;68(7):553-559
    Konsultations- und Referenzzentrum für Vaskulitis-Diagnostik, MVZ am Marienkrankenhaus gGmbH, Hamburg, Deutschland.
    A particular diagnostic situation in the classification of a granulomatous dermatitis results when no circumscribed granulomas but instead a diffuse interstitial histiocytic inflammatory infiltrate, a granulomatous vasculitis or a neoplastic lymphocytic infiltrate is found. Interstitial granulomatous dermatitis was originally described in patients with arthritis. Later, it was recognized that there are also associations with other usually immunological diseases. Read More

    Eosinophilic myocarditis presenting as acute coronary syndrome.
    Turk Kardiyol Dern Ars 2017 Jun;45(4):358-361
    Department of Cardiology, Ege University Faculty of Medicine, İzmir, Turkey.
    Eosinophilic myocarditis (EM) is a rare condition that may result from several heterogeneous eosinophilic diseases, including parasite infection, hypersensitivity reaction, vasculitis, and hypereosinophilic syndrome. Regardless of etiology, the disease may present with various cardiac conditions, such as acute coronary syndrome, heart failure, or arrhythmia. Irreversible endomyocardial fibrosis, which causes restrictive cardiomyopathy, occurs in the late phase of the disease. Read More

    Levamisole-Induced Leukocytoclastic Vasculitis with Negative Serology in a Cocaine User.
    Am J Case Rep 2017 Jun 8;18:641-643. Epub 2017 Jun 8.
    Department of Medicine, NYC Health + Hospital/Harlem, Columbia University, New York, NY, USA.
    BACKGROUND Levamisole is a common adulterant of cocaine. It can cause agranulocytosis and cutaneous vasculitis that can possibly lead to cutaneous necrosis. In all reported cases of levamisole-induced vasculitis, it has been described as a clinical syndrome characterized by a constellation of typical clinical features and a positive serum serology for ANCA levels, especially very high-titer p-ANCA levels, in the background of cocaine abuse. Read More

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