3,414 results match your criteria Hypersensitivity Vasculitis


Expanded dengue syndrome with small-medium-vessel vasculitis: A case report.

Int J Crit Illn Inj Sci 2021 Jan-Mar;11(1):39-42. Epub 2021 Mar 27.

Department of Pathology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Expanded dengue syndrome (EDS) is a well-described entity in the literature (after 2009), with various new atypical presentations being identified each year. We report a case of 38-year-old man who presented to the emergency department with high-grade, intermittent fever for 7 days along with myalgia and headache. He had multiple painless palpable purpura over both lower limbs and breathlessness from the 4 day of fever. Read More

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Diversity in STK4 Deficiency and Review of the Literature.

J Allergy Clin Immunol Pract 2021 Jun 16. Epub 2021 Jun 16.

Hacettepe University Medical School, Department of Pediatric Immunology; Hacettepe University Medical School, Institute of Child Health, Department of Pediatric Immunology.

Background: Serine-threonine kinase-4 (STK4) deficiency is an autosomal recessive (AR) combined immunodeficiency (CID).

Objective: We aimed to define characteristic clinical and laboratory features to aid the differential diagnosis and determine the most suitable therapy.

Methods: In addition to nine patients diagnosed, we reviewed 15 patients from medical literature. Read More

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Urticarial vasculitis: A Complication of SMZ-TMP therapy.

Clin Case Rep 2021 May 9;9(5):e03872. Epub 2021 Apr 9.

Department of Dermatology Mayo Clinic Florida Jacksonville FL USA.

Recognize that delayed hypersensitivity reactions to sulfonamides may present as urticated plaques with hyperpigmentation and purpura for which a diagnosis of urticarial vasculitis should be considered. Read More

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Acute Hemorrhagic Infancy of Edema: A Purpuric Rash in 6-Month-Old Infant.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211017413

Emory University, Atlanta, GA, USA.

Acute hemorrhagic edema of infancy (AHEI) is a cutaneous leukocytoclastic vasculitis presenting with purpura, ecchymosis, fever, and edema. Pediatricians must effectively differentiate AHEI from other diseases that have similar presentations but are more severe in order to treat appropriately without overutilizing expensive, unnecessary diagnostic tests. In this article, we describe a case of a 6-month-old previously well male who presented to our institution with a worsening rash and fever. Read More

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Azathioprine hypersensitivity syndrome: report of two cases.

BMJ Case Rep 2021 May 19;14(5). Epub 2021 May 19.

Pharmacy, Cairns Base Hospital, Cairns, Queensland, Australia.

Azathioprine hypersensitivity syndrome is a rare but potentially severe side effect of azathioprine use. It has a variable and non-specific presentation making it difficult to distinguish from sepsis or disease relapse. High clinical suspicion is therefore required for recognition and prompt cessation of azathioprine for symptom resolution. Read More

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Detection of in granulomas of patients with either hypersensitivity pneumonitis or vasculitis reveals that its presence is not unique for sarcoidosis.

ERJ Open Res 2021 Apr 4;7(2). Epub 2021 May 4.

Interstitial Lung Diseases Centre of Excellence, Dept of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands.

https://bit.ly/3pU0PeC. Read More

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Autologous platelet-rich plasma in the treatment of refractory wounds in cutaneous leukocytoclastic vasculitis complicated with hypertension (grade 2 moderate risk): A case report.

Transfus Apher Sci 2021 May 6:103157. Epub 2021 May 6.

Department of Blood Transfusion, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. Electronic address:

Introduction: Cutaneous leukocytoclastic vasculitis is an inflammatory variant of vasculitis with a variety of causes that only affects the skin. Its pathological manifestations include neutrophil infiltration and nuclear fragmentation. Clinically, it is characterised by a pleomorphic rash, including erythema, purpuric skin lesions, reticulocytosis, necrosis and ulceration. Read More

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Mechanisms of sterile inflammation after intravitreal injection of antiangiogenic drugs: a narrative review.

Int J Retina Vitreous 2021 May 7;7(1):37. Epub 2021 May 7.

Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.

Background: Intraocular inflammation is an uncommon but potentially vision-threatening adverse event related to anti-VEGF therapy. This is of increasing importance given both the volume of injections performed, as well as the increased prevalence of inflammation seen with newer anti-VEGF agents. Brolucizumab, the newest anti-VEGF agent, has been associated with an inflammatory retinal vasculitis and the underlying mechanism is unclear. Read More

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Emerging Skin Toxicities in Patients with Breast Cancer Treated with New Cyclin-Dependent Kinase 4/6 Inhibitors: A Systematic Review.

Drug Saf 2021 Jul 6;44(7):725-732. Epub 2021 May 6.

Department of Dermatology, San Gallicano Dermatological Institute-IRCCS, Via Elio Chianesi 53, 00144, Rome, Italy.

Three cyclin-dependent kinases 4/6, including palbociclib, ribociclib, and abemaciclib, have been approved for the treatment of patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative advanced breast cancer. The objective of this study was to evaluate the occurrence and clinical spectrum of cutaneous adverse events in patients with breast cancer following therapy with cyclin-dependent kinase 4/6 inhibitors. A systematic literature search was performed in the PubMed, Cochrane, and EMBASE databases up to November 2020 to evaluate studies published from 2015 to 2020. Read More

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A Case of Cutaneous Leukocytoclastic Vasculitis Associated with Granulocyte Colony-Stimulating Factor: An Unusual Presentation.

Ann Dermatol 2020 Apr 11;32(2):164-167. Epub 2020 Mar 11.

Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Drug-induced vasculitis is an inflammation of small-sized blood vessel caused by the use of drugs. It accounts for approximately 10% of acute cutaneous vasculitis. Propylthiouracil, hydralazine, and allopurinol have been widely known as causative agents. Read More

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Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases.

J Am Acad Dermatol 2021 07 7;85(1):46-55. Epub 2021 Apr 7.

Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Medical Practice Evaluation Center, Mongan Institute, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Cutaneous reactions after messenger RNA (mRNA)-based COVID-19 vaccines have been reported but are not well characterized.

Objective: To evaluate the morphology and timing of cutaneous reactions after mRNA COVID-19 vaccines.

Methods: A provider-facing registry-based study collected cases of cutaneous manifestations after COVID-19 vaccination. Read More

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Cutaneous leukocytoclastic vasculitis at diagnosis of hairy cell leukemia successfully treated with vemurafenib and rituximab.

Leuk Res 2021 May 30;104:106571. Epub 2021 Mar 30.

Department of Hematology, Medical University of Lodz and Copernicus Memorial Hospital, Lodz, Poland. Electronic address:

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Leucocytoclastic vasculitis secondary to COVID-19 infection in a young child.

BMJ Case Rep 2021 Apr 7;14(4). Epub 2021 Apr 7.

Paediatrics, Case Western Reserve University Hospital, Cleveland, Ohio, USA.

The current case report describes a 13-year-old young boy who presented with purpuric rashes following a completely asymptomatic COVID-19 infection and biopsy-confirmed leucocytoclastic vasculitis, mild haematuria and mild elevation of serum IgA. This case highlights one of the dermatological manifestations of COVID-19 infection which has not been reported so far. Paediatricians should explore the history of this infection when evaluating any child presenting with a vasculitic rash. Read More

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A Rare Case of Henoch-Schönlein Purpura and Mycobacterium xenopi Pulmonary Infection.

Cureus 2021 Feb 24;13(2):e13533. Epub 2021 Feb 24.

General Surgery, Lebanese American University-Medical Center, Beirut, LBN.

Henoch-Schönlein purpura (HSP) is a small-vessel vasculitis with cutaneous, articular, gastrointestinal, and renal manifestations. Leukocytoclastic vasculitis and IgA deposits are classically found when involved skin and kidneys are biopsied. The disease's etiology remains unknown, although many bacterial and viral infections have been described as triggering factors. Read More

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February 2021

Henoch-Schönlein Purpura Presenting with Acute Abdomen.

J Coll Physicians Surg Pak 2021 Mar;31(3):350-352

Department of General Surgery, Abant Izzet Baysal University Hospital, Bolu, Turkey.

Henoch-Schönlein Purpura (HSP) is an autoimmune, systemic, non-granulomatous vasculitis characterised by self-limiting clinical course, and leukocytoclastic vasculitis of small vessels. Deposition of immune complexes that contain IgA is the hallmark of vascular involvement. Adults with HSP have a higher incidence of complications and death. Read More

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Periprosthetic Tissue Reaction Independent of LTT Result and Implanted Materials in Total Knee Arthroplasty.

J Arthroplasty 2021 Jul 18;36(7):2480-2485. Epub 2021 Feb 18.

Department of Orthopaedic Surgery, Harbor-UCLA Medical Center, Torrance CA; Joint Replacement Institute at St. Vincent Medical Center, Los Angeles CA.

Background: An allergic reaction may rarely cause a painful or stiff total knee arthroplasty (TKA). However, no consensus diagnostic criteria for TKA immune failure exist. Lymphocyte transformation testing (LTT) measures immune sensitivity to various materials, but its role in diagnosing an allergic reaction to a TKA has not been established. Read More

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[Disseminated infection caused by the bacillus Calmette-Guérin vaccine and SARS-CoV-2 coinfection in a patient with IL-12 receptor β1 subunit deficiency].

Rev Alerg Mex 2020 Oct-Dec;67(4):401-407

Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Hospital de Especialidades, Ciudad de México, México.

Background: Inborn errors of immunity manifest with a greater susceptibility to infections, autoimmunity, autoinflammatory diseases, allergies, or malignancies. One of these is the mendelian susceptibility to mycobacterial disease. The most frequent etiology is the complete autosomal recessive deficiency of the β1 subunit of the interleukin 12 receptor. Read More

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Mediterranean spotted fever associated with leucocytoclastic vasculitis and acute pancraeatitis.

BMJ Case Rep 2021 Feb 23;14(2). Epub 2021 Feb 23.

Laniado Hospital, Sanz Medical Centre, Netanya, Israel.

A young healthy gardener became febrile with abdominal pain, nausea, vomiting and diarrhoea followed by palpable purpura, mostly on the legs and buttocks with associated arthralgia. Dehydration, azotemia and hyponatraemia resolved with fluid replacement. Tests demonstrated acute pancreatitis, hepatitis, thrombocytopenia, microscopic haematuria and proteinuria. Read More

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February 2021

Leukocytoclastic Vasculitis in Cutaneous Crohn Disease in the Setting of COVID-19.

Inflamm Bowel Dis 2021 05;27(6):e74-e75

Department of Medicine, Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois, USA.

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The role of IL-8 in skin lesions of a patient with erythema elevatum diutinum.

J Eur Acad Dermatol Venereol 2021 Jun 3;35(6):e396-e399. Epub 2021 Mar 3.

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

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Cutaneous leukocytoclastic vasculitis secondary to COVID-19 infection: A case report.

Clin Case Rep 2021 Feb 18;9(2):830-834. Epub 2020 Dec 18.

Faculty of Pharmaceutical Sciences Isfahan University of Medical Sciences Isfahan Iran.

COVID-19 is a novel disease that mostly affects the respiratory system but as the number of cases is rising significantly around the world, more extra-respiratory manifestations are being reported among which are various dermatologic manifestations. Read More

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February 2021

Leukocytoclastic Vasculitis Mimicking Henoch-Schönlein Purpura Preceding Onset of Ulcerative Colitis in a Child.

Indian J Pediatr 2021 05 16;88(5):507-508. Epub 2021 Feb 16.

Department of Pediatrics, Bharati Vidyapeeth University Medical College Hospital & Research Centre, Pune, Maharashtra, 411043, India.

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Infant with a rapidly progressing rash.

BMJ Case Rep 2021 Jan 25;14(1). Epub 2021 Jan 25.

Department of Pediatrics, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.

An infant presented to the emergency department with sudden onset of rapidly progressing erythematous macules and distal oedema. The rash was striking in appearance, covering most of the body, which raised concern for pressing infectious (eg, meningococcaemia) and other serious aetiologies. Nevertheless, the infant remained playful and was overall stable and posed a diagnostic and management dilemma. Read More

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January 2021

Adverse Reactions Induced by Minocycline: A Review of Literature.

Curr Drug Saf 2021 Jan 19. Epub 2021 Jan 19.

Government Medical College, Kottayam. India.

Background: Minocycline is a tetracycline antibiotic that is widely used to treat infections, and is a first-line oral antibiotic in the treatment of moderate to severe inflammatory acne. Although it has high efficacy, several adverse reactions, including life-threatening ones have been reported in association with its use.

Objective: To identify all the potential adverse reactions due to minocycline and analyze them in terms of the number of cases reported so far, salient features, severity and clinical outcome. Read More

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January 2021

Biology of peripheral ulcerative keratitis.

Exp Eye Res 2021 Mar 23;204:108458. Epub 2021 Jan 23.

University of Sao Paulo, Sao Paulo, SP, Brazil. Electronic address:

Peripheral ulcerative keratitis (PUK) is a progressive peripheral thinning of the corneal stroma caused by proinflammatory mediators' release from corneal limbal vasculitis. The clinical presentation is an epithelial defect with a crescent-shaped stromal inflammation. Its exact pathophysiologic mechanisms of PUK remain partially understood, but the overall understanding of the fundamental processes that mediate and effect corneal immunity has continued to expand over the past 25 years. Read More

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Exuberant bullous vasculitis associated with SARS-CoV-2 infection.

IDCases 2021 12;23:e01047. Epub 2021 Jan 12.

Federal University of Pernambuco, Department of Dermatology, Recife, Brazil.

We described a case of exuberant cutaneous small-vessel vasculitis in a 27-year-old male with mild CoVID-19 in Brazil. The patient presented painful purpuric papules and vesicobullous lesions with hemorrhagic content located in the larger amount in the lower limbs and, to a lesser extent in the region of the back and upper limbs, saving palms and soles of the feet. Influenza-like syndrome with anosmia and ageusia was reported seven days before the skin lesions. Read More

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January 2021

Œdème aigu hémorragique du nourrisson.

CMAJ 2021 01;193(2):E78

Service de dermatologie (Gao, Yen, Chen) et Centre clinique et de recherche sur l'hypersensibilité aux médicaments (Chen), Chang Gung Memorial Hospital, Linkou (Taïwan); École de médecine (Gao, Yen, Chen), Chang Gung University, Taoyuan (Taïwan); Graduate Institute of Immunology (Chen), École de médecine, Université nationale de Taïwan, Taipei (Taïwan).

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January 2021

Palisaded neutrophilic granulomatous dermatitis, interstitial granulomatous dermatitis and IgA vasculitis associated with incomplete Sjögren's syndrome.

J Dermatol 2021 Apr 6;48(4):556-558. Epub 2021 Jan 6.

Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago, Japan.

Palisaded neutrophilic granulomatous dermatitis (PNGD) and interstitial granulomatous dermatitis (IGD) are rare granulomatous disorders. Differential diagnosis of PNGD and IGD is often difficult, but both conditions occasionally exist together. We report here the first potential overlapping case of PNGD, IGD, and Immunoglobulin A (IgA) vasculitis associated with incomplete Sjögren's syndrome. Read More

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Atypical Bacterial Pathogens and Small-Vessel Leukocytoclastic Vasculitis of the Skin in Children: Systematic Literature Review.

Pathogens 2021 Jan 2;10(1). Epub 2021 Jan 2.

Faculty of Biomedicine, Università della Svizzera Italiana, 6900 Lugano, Switzerland.

Leukocytoclastic small-vessel vasculitis of the skin (with or without systemic involvement) is often preceded by infections such as common cold, tonsillopharyngitis, or otitis media. Our purpose was to document pediatric (≤18 years) cases preceded by a symptomatic disease caused by an atypical bacterial pathogen. We performed a literature search following the Preferred Reporting of Systematic Reviews and Meta-Analyses guidelines. Read More

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January 2021

Dermatologic comorbidities of the patients with severe COVID-19: A case-control study.

Dermatol Ther 2021 Jan 10;34(1):e14731. Epub 2021 Jan 10.

Department of Dermatology and Venereology, Yıldırım Beyazıt University, Ankara City Hospital, Ankara, Turkey.

The current studies focus on the association between COVID-19 and certain comorbidities. To the best of our knowledge, the association between severe COVID-19 and dermatologic comorbidities has not been reported yet. In this study, we aimed to describe the dermatologic comorbidities of patients with severe COVID-19 and compare it with the control group. Read More

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January 2021