3,298 results match your criteria Hypersensitivity Vasculitis


Alcohol-Associated Immunoglobulin A Vasculitis: A Case Report and Review of the Literature.

Dermatopathology (Basel) 2019 Oct-Dec;6(4):288-293. Epub 2020 Jun 2.

Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Immunoglobulin A (IgA)-mediated leukocytoclastic vasculitis is a cutaneous small-vessel vasculitis characterized by skin findings of palpable purpura. It may occur secondary to infections, neoplasms, drugs, and systemic conditions, although it is most commonly idiopathic. A known, but rare, trigger for IgA vasculitis is alcohol consumption. Read More

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http://dx.doi.org/10.1159/000507307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315200PMC

IgA Expression in Adult Cutaneous Leukocytoclastic Vasculitis and its Effect on Hospital Outcomes.

J Am Acad Dermatol 2020 Jun 22. Epub 2020 Jun 22.

The Ohio State University Wexner Medical Center Division of Dermatology. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.06.062DOI Listing

Normocomplementemic Urticarial Vasculitis: An Unusual Presentation.

Indian J Dermatol 2020 May-Jun;65(3):208-210

Department of Internal Medicine, Baby Memorial Hospital, Kozhikode, Kerala, India.

Urticarial vasculitis (UV) is a form of cutaneous vasculitis which lasts for >24 h. Clinically, the patients present with erythema and wheals. The level of complement decides the type of UV. Read More

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http://dx.doi.org/10.4103/ijd.IJD_227_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292463PMC

Update on vasculitis: overview and relevant dermatological aspects for the clinical and histopathological diagnosis - Part II.

An Bras Dermatol 2020 Jul - Aug;95(4):493-507. Epub 2020 May 24.

Department of Dermatology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Vasculitis is a group of several clinical conditions in which the main histopathological finding is fibrinoid necrosis in the walls of blood vessels. This article assesses the main dermatological aspects relevant to the clinical and laboratory diagnosis of small- and medium-vessel cutaneous and systemic vasculitis syndromes. The most important aspects of treatment are also discussed. Read More

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http://dx.doi.org/10.1016/j.abd.2020.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335877PMC
May 2020
0.866 Impact Factor

Leukocytoclastic Vasculitis: An Early Skin Biopsy Makes a Difference.

Cureus 2020 May 1;12(5):e7912. Epub 2020 May 1.

Internal Medicine, University of Connecticut, Farmington, USA.

Leukocytoclastic vasculitis (LCV) is an uncommon condition with a broad differential diagnosis. Although the clinical history, physical examination, and laboratory workup are pivotal when formulating a differential diagnosis of LCV, a skin biopsy is required in most cases to elucidate the cause. The diagnostic yield of a skin biopsy increases within the first 24 to 48 hours of the lesion onset indicating the importance of obtaining a prompt skin sample. Read More

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http://dx.doi.org/10.7759/cureus.7912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263727PMC

A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jun 3;21(1):466. Epub 2020 Jun 3.

Clinical Pharmacology Department, Clinical Trial Unit, La Paz University Hospital - IdiPAZ, Paseo de la Castellana, 261, 28046, Madrid, Spain.

Objectives: Primary objective: to evaluate the efficacy of melatonin as a prophylactic treatment on prevention of symptomatic SARS-CoV-2 infection among healthcare workers at high risk of SARS-CoV-2 exposure. Secondary objectives: To evaluate the efficacy of melatonin as a prophylactic treatment on prevention of asymptomatic SARS-CoV-2 infection.To evaluate the efficacy of melatonin to prevent the development of severe COVID-19 in the participants enrolled in this study who develop SARS-CoV-2 infection along the trial. Read More

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http://dx.doi.org/10.1186/s13063-020-04436-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267766PMC

Type 3 hypersensitivity in COVID-19 vasculitis.

Clin Immunol 2020 May 29;217:108487. Epub 2020 May 29.

Institute of Pathology, University of Modena and Reggio Emilia, Modena, Italy.

Coronavirus Disease 2019 (COVID-19) is an ongoing public health emergency and new knowledge about its immunopathogenic mechanisms is deemed necessary in the attempt to reduce the death burden, globally. For the first time in worldwide literature, we provide scientific evidence that in COVID-19 vasculitis a life-threatening escalation from type 2 T-helper immune response (humoral immunity) to type 3 hypersensitivity (immune complex disease) takes place. The subsequent deposition of immune complexes inside the vascular walls is supposed to induce a severe inflammatory state and a cytokine release syndrome, whose interleukin-6 is the key myokine, from the smooth muscle cells of blood vessels. Read More

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http://dx.doi.org/10.1016/j.clim.2020.108487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256503PMC

Three Patterns of Cutaneous Involvement in Granulomatosis with Polyangiitis.

J Adv Res 2020 Jul 7;24:311-315. Epub 2020 May 7.

National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, AP-HP, Paris Descartes University, Paris, France.

Background: Skin involvement in granulomatosis with polyangiitis (GPA) is common and can appear as an initial presentation of the disease or more commonly through its course.

Case Presentation: We report a case of a 24-year-old male patient, previously diagnosed as having GPA, admitted with fever, hemoptysis, generalized hemorrhagic blisters associated with arthralgia, fatigue, myalgia, nasal crusting, and vertigo. Three weeks prior to admission, he developed erythematous papules on both elbows, and purpuric papules on both lower limbs. Read More

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http://dx.doi.org/10.1016/j.jare.2020.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235938PMC

Cutaneous Vasculitis: Review on Diagnosis and Clinicopathologic Correlations.

Clin Rev Allergy Immunol 2020 May 6. Epub 2020 May 6.

Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP-HP, 27, rue du Faubourg Saint-Jacques, 75679, Paris Cedex 14, France.

Cutaneous vasculitis is an inflammatory disease affecting the dermal blood vessel walls. The skin is a privileged organ in the setting of vasculitis since it is easily accessible for physical examination and safe biopsy, allowing an accurate characterization of inflammatory lesions. The skin is often involved. Read More

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http://dx.doi.org/10.1007/s12016-020-08788-4DOI Listing

[Cutaneous vasculitis and vasculopathy : Differential diagnosis in biopsies of the lower extremities].

Pathologe 2020 Jul;41(4):355-363

, Dermatopathologie Lübeck, Deutschland.

The skin is one of the most frequently involved organs in primary systemic and secondary vasculitis; moreover, a vasculitis can occur as single organ vasculitis, limited to the skin. For most types of vasculitis, the lower extremities constitute common sites with clinical symptoms of palpable purpura, nodules, and ulcers. In histopathology of cutaneous vasculitis, it is of utmost importance to correctly identify the vessel types involved and to discriminate between vasculitic vessel damage, unspecific reactive vessel changes, vascular occlusive diseases, noninflammatory purpura, or perivascular infiltrates due to other inflammatory skin diseases. Read More

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http://dx.doi.org/10.1007/s00292-020-00786-9DOI Listing

A Detailed Analysis of the Distribution, Morphology, and Histopathology of Complex Purpura in Hospitalized Patients: A Case Series of 68 Patients.

J Am Acad Dermatol 2020 May 3. Epub 2020 May 3.

Yale School of Medicine Department of Dermatology and; Department of Pathology, New Haven, Connecticut. Electronic address:

Background: Purpura in inpatients commonly leads to dermatologic consultation. The differential diagnosis is broad and algorithms are intricate.

Objective: We evaluated inpatient consultations for complex purpura to document the most common diagnoses and to validate the true diagnostic utility of histopathology, clinical morphology, and distribution. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.149DOI Listing

Cutaneous arteriolitis: A novel cutaneous small vessel vasculitis disorder clinicopathologically different from cutaneous polyarteritis nodosa and cutaneous venulitis.

J Cutan Pathol 2020 Apr 27. Epub 2020 Apr 27.

Meguro Chen Dermatology Clinic, Tokyo, Japan.

Cutaneous vasculitis can be classified into two types based on the affected vessel size: small vessel vasculitis predominantly affecting dermal venules, and muscular vessel vasculitis as found in cutaneous arteritis predominantly affecting arteries located at the dermal-subcutaneous junction. We describe two cases with a novel small vessel vasculitis disorder, which exclusively affected arterioles in the mid-dermis, and demonstrate clinical and pathological difference distinct from cutaneous polyarteritis nodosa and cutaneous venulitis. Both patients were male, and presented with painful infiltrative plaques, involving the palms, soles, and thighs without extracutaneous involvement except for fever and arthralgia. Read More

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http://dx.doi.org/10.1111/cup.13726DOI Listing

Update on vasculitis: an overview and dermatological clues for clinical and histopathological diagnosis - part I.

An Bras Dermatol 2020 May - Jun;95(3):355-371. Epub 2020 Mar 26.

Discipline of Dermatology, Faculdade de Medicina do ABC, Santo André, SP, Brazil; Postgraduate Program, Faculdade de Medicina do ABC, Santo André, SP, Brazil.

The term vasculitis refers to the inflammation of vessel walls. It may range in severity from a self-limited disorder in one single organ to a life-threatening disease due to multiple organ failure. It has many causes, although they result in only a few histological patterns of vascular inflammation. Read More

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http://dx.doi.org/10.1016/j.abd.2020.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253914PMC
June 2020
0.866 Impact Factor

A case of Henoch-Schönlein purpura associated with scrub typhus.

BMC Infect Dis 2020 Apr 17;20(1):286. Epub 2020 Apr 17.

Division of Infectious Diseases, Department of Internal Medicine, Inha University College of Medicine, 7-206, Shinheung-Dong, Jung-Gu, Incheon, 22332, Republic of Korea.

Background: Henoch-Schönlein purpura (HSP) may be caused by several allergens. However, to date, HSP caused by Orientia tsutsugamushi has not been reported. Here, we report an unusual rash with features of HSP caused by Orientia tsutsugamushi. Read More

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http://dx.doi.org/10.1186/s12879-020-05001-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165380PMC

[Treatment of ocular tuberculosis-an update].

Ophthalmologe 2020 Apr 15. Epub 2020 Apr 15.

Berner Augenklinik am Lindenhofspital, Swiss Eye Institute, Bremgartenstr. 119, 3012, Bern, Schweiz.

Background: Tuberculous uveitis (TU) is initially usually not acute, accompanied by only slight visual disorders and affects otherwise healthy individuals so that the diagnosis is frequently primarily overlooked.

Objective: This study was carried out to provide an update of the treatment options in suspected TU.

Material And Methods: A PubMed search was undertaken using the key terms uveitis AND tuberculosis AND treatment for manuscripts published within the last decade. Read More

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http://dx.doi.org/10.1007/s00347-020-01099-1DOI Listing

Retinal arterial occlusive vasculitis following intravitreal brolucizumab administration.

Am J Ophthalmol Case Rep 2020 Jun 31;18:100680. Epub 2020 Mar 31.

Sierra Eye Associates, Reno, NV, USA.

Purpose: To describe retinal arterial occlusion and vasculitis following intravitreal brolucizumab administration in a patient with neovascular age-related macular degeneration (nAMD).

Observation: An 88-year-old Caucasian woman with neovascular age-related macular degeneration (nAMD) complained of painless loss of vision with light sensitivity in both eyes (OU) four weeks after bilateral intravitreal brolucizumab. Upon examination, her visual acuity decreased to 20/40 in the right eye (OD) and 20/50 in the left eye (OS). Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125319PMC

Interstitial Lung Disease in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Patients: Comparison With Idiopathic Pulmonary Fibrosis.

J Clin Rheumatol 2020 Mar 31. Epub 2020 Mar 31.

Division of Rheumatology, Mayo Clinic, Jacksonville, FL.

Background/objective: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) may involve the kidney, respiratory tract, skin, or central and peripheral nervous system. Reports of interstitial lung disease (ILD) in AAV (AAV-ILD) have been increasing.

Methods: We reviewed the medical records of all patients with AAV-ILD between January 1, 2007, and December 31, 2017, and compared their pulmonary involvement to patients with idiopathic pulmonary fibrosis (IPF). Read More

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http://dx.doi.org/10.1097/RHU.0000000000001357DOI Listing

A fatal case of severe systemic varicella zoster infection in a patient with chronic use of immunosuppressive agents for cutaneous vasculitis.

IDCases 2020 9;19:e00667. Epub 2019 Nov 9.

Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taipei, Taiwan.

Acute varicella zoster virus (VZV) infection is a common condition in children, which is considered a mild, self-limited disease with diffuse skin vesicular rash. However, disseminated VZV infection with multiple organ involvement can occur in immunocompromised patients with impaired T cell immunity including solid or hematopoietic stem cell transplant recipients, receiving immunosuppressive therapy, leukemia, lymphoma, and HIV infection. Prompt antiviral therapy is mandatory in those immunocompromised persons. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093748PMC
November 2019

The rashes that lead to cutaneous ulcers.

Clin Dermatol 2020 Jan - Feb;38(1):42-51. Epub 2019 Nov 16.

The Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Brazil.

Skin rashes have exanthema as a synonym, a term derived from the Greek words exanthem, meaning "to appear," and anthos, which denotes "flourishing." The relevant factors for characterization of a rash include distribution, configuration, and organization of the lesions, in addition to evidence of systemic involvement through toxemia, adenopathy, and conjunctive lesions, hepatosplenomegaly, excoriations or phlogosis, neck rigidity, or neurologic dysfunction. A rash may evolve to cutaneous ulceration in many instances, which is relevant for the diagnosis, the followup, and the therapeutic management of the patient. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.10.021DOI Listing
November 2019

Aleukemia cutis: Clinicopathological and molecular investigation of two cases.

J Cutan Pathol 2020 Mar 20. Epub 2020 Mar 20.

Department of Pathology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

We describe two cases of acute myeloid leukemia (AML) who presented with cutaneous manifestations. Leukemia cutis (LC) is the cutaneous presentation of any type of leukemia and occurs in 10% to 15% of patients with AML, but cutaneous infiltration of AML rarely precedes the involvement of the bone marrow or peripheral blood and is called as "aleukemia cutis." Our first case presented with facial skin thickening, a manifestation which is known as lionization and his initial clinical diagnosis was nonspecific allergic reaction. Read More

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http://dx.doi.org/10.1111/cup.13690DOI Listing
March 2020
1.560 Impact Factor

Diffuse cutaneous reaction following PPV-23 pneumococcal vaccine: an immunisation-associated hypersensitivity vasculitis.

BMJ Case Rep 2020 Mar 18;13(3). Epub 2020 Mar 18.

Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland.

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http://dx.doi.org/10.1136/bcr-2020-234714DOI Listing

Exuberant case of erythema elevatum diutinum in a patient infected with HIV and hepatitis B virus.

An Bras Dermatol 2020 Mar - Apr;95(2):200-202. Epub 2020 Feb 12.

Department of General Medicine, Teaching Hospital, Universidade Federal de Pelotas, Pelotas, RS, Brazil.

Erythema elevatum diutinum is a small vessel vasculitis which is benign, rare, and chronic. It is clinically characterized by violaceous, brown, or yellowish plaques, nodules, and papules. It has been associated with autoimmune, infectious, and neoplastic processes. Read More

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http://dx.doi.org/10.1016/j.abd.2019.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175035PMC

Does a Subset of Localized Chronic Fibrosing Vasculitis Represent Cutaneous Manifestation of IgG4-Related Disease/a Histologic Pattern of IgG4-Related Skin Disease? A Reappraisal of an Enigmatic Pathologic Entity.

Authors:
Tien Anh Tran

Am J Dermatopathol 2020 Feb 25. Epub 2020 Feb 25.

Department of Pathology, Advent Health Orlando, Orlando, FL.

Localized chronic fibrosing vasculitis (LCFV) is a rare cutaneous fibroinflammatory and vasculitic process of poorly defined etiology. Furthermore, controversy remains as to whether LCFV represents a primary pathologic process or a histologic pattern. The current case documents a 52-year-old male patient with a scrotal mass and clinical history of a retroperitoneal mass as well as a previously resected tumor of the right submandibular salivary gland displaying morphologic features of eosinophilic angiocentric fibrosis. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001630DOI Listing
February 2020

Cutaneous Vasculitis with Gut Involvement During Secukinumab Treatment for Psoriatic Arthritis.

Acta Derm Venereol 2020 Mar 12;100(6):adv00077. Epub 2020 Mar 12.

Department of Dermatology-Venereology, Robert-Debré Hospital, Reims, France.

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http://dx.doi.org/10.2340/00015555-3435DOI Listing

Severe clopidogrel-induced DRESS with eosinophilic pneumonia associated with Epstein-Barr virus reactivation.

Respirol Case Rep 2020 Apr 20;8(3):e00541. Epub 2020 Feb 20.

Clinical Research Center National Hospital Organization, Kinki-Chuo Chest Medical Center Osaka Japan.

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a type of hypersensitivity drug reaction. Here, we report the case of a 78-year-old man who presented with a rash, fever, dry cough, and swollen parotid glands who had been prescribed clopidogrel for one year. Computed tomography showed consolidation and interlobular septal thickening with enlarged mediastinal lymph nodes. Read More

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http://dx.doi.org/10.1002/rcr2.541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031645PMC

Treatment of refractory IgA vasculitis with dapsone: a systematic review.

Clin Exp Pediatr 2020 May 24;63(5):158-163. Epub 2019 Sep 24.

Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.

IgA vasculitis, formerly known as Henoch-Schönlein purpura, is a systemic IgA-mediated vasculitis of the small vessels commonly seen in children. The natural history of IgA vasculitis is generally self-limiting; however, one-third of patients experience symptom recurrence and a refractory course. This systematic review examined the use of dapsone in refractory IgA vasculitis cases. Read More

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http://dx.doi.org/10.3345/kjp.2019.00514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254170PMC

Nickel Allergy: Epidemiology, Pathomechanism, Clinical Patterns, Treatment, and Prevention Programs.

Endocr Metab Immune Disord Drug Targets 2020 Jan 28. Epub 2020 Jan 28.

Dermatology Section, Department of Medicine, University of Perugia, Perugia, Italy.

Background: Nickel is the most common cause of contact allergy in general population and the most frequently detected allergen in patients patch tested for suspected allergic contact dermatitis (ACD). Nickel Allergy: ACD from nickel is a typical type IV hypersensitivity. Nickel allergy is mostly caused by non-occupational exposure, such as jewelry and clothing decorations, metal tools, medical devices (mainly orthopedic and orthodontic implants, cardiovascular prosthesis), eyeglasses, utensils, keys, pigment for paint, cosmetics and food (mainly legumes, chocolate, salmon, peanuts). Read More

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http://dx.doi.org/10.2174/1871530320666200128141900DOI Listing
January 2020

Early diagnosis and treatment of Leukocytoclastic Vasculitis: case report.

J Vasc Bras 2020 Jan 7;19:e20180072. Epub 2020 Jan 7.

Faculdade de Medicina do ABC, Santo André, SP, Brasil.

A 46-year-old female patient presented at the emergency department of a Municipal University Hospital with necrotic lesions in lower limbs associated with wasting syndrome. She was diagnosed with leukocytoclastic vasculitis after physical examination and history-taking in a fast and cost-effective manner, using an algorithm specifically for primary vasculitis, enabling early and appropriate treatment. The good clinical outcome demonstrates the need to quickly make a definitive diagnosis and start treatment. Read More

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http://dx.doi.org/10.1590/1677-5449.190072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956624PMC
January 2020

Disseminated cutaneous herpes zoster and multiple cerebral infarcts in an adult with diabetes mellitus.

J Neurovirol 2020 02 15;26(1):130-132. Epub 2020 Jan 15.

Department of Neurology, Shuang Ho Hospital, Taipei Medical University, No. 291, Zhongzheng Rd., Zhonghe District, New Taipei City, 23561, Taiwan.

Ischemic stroke is a rare complication of varicella-zoster virus (VZV) infection. We present the case of a patient with a medical history of type 2 diabetes mellitus (DM) who experienced disseminated cutaneous VZV infection followed by multiple cerebral infarcts associated with VZV vasculopathy. Brain magnetic resonance imaging revealed multiple hyperintense lesions over the bilateral deep white matter and basal ganglia. Read More

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http://dx.doi.org/10.1007/s13365-019-00790-7DOI Listing
February 2020

Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura) - a dramatic presentation for a benign disease.

F1000Res 2019 17;8:1771. Epub 2019 Oct 17.

Department of Pediatrics, Pugliese Ciaccio Hospital, Catanzaro, Italy.

We present a case of an 11-month-old girl who was referred to our unit for an erythematous rash that appeared on the face and extremities. Personal and family history was not relevant. Laboratory tests were normal. Read More

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http://dx.doi.org/10.12688/f1000research.20645.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944248PMC

[IgA vasculitis with massive hemorrhage from the jejunum after steroid administration].

Nihon Shokakibyo Gakkai Zasshi 2020 ;117(1):64-71

Department of Gastroenterology and Hepatology, Okayama University Hospital.

A 45-year-old Japanese man presenting with leg purpura, abdominal pain, and arthralgia was diagnosed with IgA vasculitis. His symptoms resolved after the intravenous administration of prednisolone. However, on day 20 of admission, he experienced bloody discharge and hypovolemic shock. Read More

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http://dx.doi.org/10.11405/nisshoshi.117.64DOI Listing
January 2020

Type II acquired cutis laxa associated with recurrent urticarial vasculitis: brief report.

Allergy Asthma Clin Immunol 2020 3;16. Epub 2020 Jan 3.

1Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 China.

Background: Cutis laxa is a connective tissue disease characterized by loose, wrinkled, and redundant skin. It is either inherited or acquired. In most cases, acquired cutis laxa is associated with neoplasms, drugs, and autoimmune diseases. Read More

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http://dx.doi.org/10.1186/s13223-019-0401-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942328PMC
January 2020

An Uncommon Coexistence of Sarcoidosis and Cutaneous Leukocytoclastic Vasculitis in an Adult.

Indian J Dermatol 2019 Nov-Dec;64(6):486-489

Chest Diseases Clinic, Respiratory Intensive Care Unit, Istanbul Süreyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Health Sciences University, Istanbul, Turkey.

The skin is the second most commonly involved organ after pulmonary system in sarcoidosis, a multisystemic granulomatous disease. Cutaneous small-vessel vasculitis (leukocytoclastic vasculitis [LCV]) is a disorder characterized by neutrophilic inflammation of small blood vessels. Although the skin is the organ where LCV is seen most frequently, extracutaneous involvements are also seen. Read More

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http://dx.doi.org/10.4103/ijd.IJD_291_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862359PMC
January 2020

Papulonecrotic tuberculid secondary to Mycobacterium avium complex.

Cutis 2019 Nov;104(5):E11-E13

Department of Dermatology, Weill Cornell Medicine, New York, New York, USA.

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November 2019

Multiple Lobulated Nodules: Answer.

Am J Dermatopathol 2020 Jan;42(1):61-62

Pathology, Royal Liverpool and Broadgreen University Hospitals NHS trust, Liverpool, United Kingdom.

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http://dx.doi.org/10.1097/DAD.0000000000001281DOI Listing
January 2020

Erythema Elevatum Diutinum - Two Case Reports, Two Different Clinical Presentations, and a Short Literature Review.

Open Access Maced J Med Sci 2019 Sep 30;7(18):3039-3042. Epub 2019 Aug 30.

Department of Dermatology, University of Rome "G. Marconi", Rome, Italy.

Background: Erythema elevatum diutinum (EED) belongs to the spectrum of cutaneous leukocytoclastic vasculitides. EED is a very rare dermatosis presenting with reddish to browning papules and plaques. EED may be associated with infections, hematologic and autoimmune disorders. Read More

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http://dx.doi.org/10.3889/oamjms.2019.765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910801PMC
September 2019

Diagnoses of hospitalized patients with skin abnormalities prompting biopsy by consulting dermatologists: A 3-year review from a tertiary care center.

J Cutan Pathol 2020 Apr 26;47(4):346-356. Epub 2019 Dec 26.

Department of Dermatology, Cleveland Clinic, Cleveland, Ohio.

Background: Dermatologists play an important role in diagnosing and managing hospitalized patients with cutaneous abnormalities. Skin biopsies remain an indispensable tool for aiding dermatologists in accurate diagnosis and treatment. We aimed to determine the range of conditions, and the most common conditions, prompting skin biopsy by dermatology hospital consultation (HCON) services to aid in evaluation of hospitalized patients. Read More

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http://dx.doi.org/10.1111/cup.13628DOI Listing

The leukotriene receptor antagonist Montelukast can induce adverse skin reactions in asthmatic patients.

Pulm Pharmacol Ther 2020 02 11;60:101875. Epub 2019 Dec 11.

School and Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy. Electronic address:

Montelukast the leukotriene receptor antagonist is an anti-inflammatory drug that causes bronchodilation and for this reason it is used to improve inflammatory states in asthma and allergic rhinitis. Montelukast is generally considered a safe drug with the occurrence of a few adverse drug reactions (ADRs) and anti-leucotrienes are usually well-tolerated by adults and young patients. Starting from these premises the purpose of this review is so give un up-to-date scenario about skin adverse reactions due to Montelukast administration. Read More

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http://dx.doi.org/10.1016/j.pupt.2019.101875DOI Listing
February 2020

Cutaneous manifestations of bartonellosis.

An Bras Dermatol 2019 Sep - Oct;94(5):594-602. Epub 2019 Oct 2.

Laboratory of Applied Research in Dermatology and Bartonella Infection, School of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil; Discipline of Dermatology, Department of Clinical Medicine, School of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil. Electronic address:

Bartonellosis are diseases caused by any kind of Bartonella species. The infection manifests as asymptomatic bacteremia to potentially fatal disorders. Many species are pathogenic to humans, but three are responsible for most clinical symptoms: Bartonella bacilliformis, Bartonella quintana, and Bartonella henselae. Read More

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http://dx.doi.org/10.1016/j.abd.2019.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857551PMC
December 2019
0.866 Impact Factor

Methimazole-Induced Leukocytoclastic Vasculitis: A Case Report.

Case Rep Dermatol 2019 Sep-Dec;11(3):303-309. Epub 2019 Nov 1.

Division of Dermatology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Major identifiable causes of leukocytoclastic vasculitis include certain infections and medications. Amongst antithyroid drugs, methimazole (MMI) is rarely implicated as a culprit drug. We report the first case, in Thailand, of MMI-induced leukocytoclastic vasculitis in a 41-year-old Thai female who had received MMI for relapsed Graves' disease. Read More

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http://dx.doi.org/10.1159/000503990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873099PMC
November 2019

Erythema Nodosum: A Manifestation of Salmonella Infection.

Case Rep Gastroenterol 2019 Sep-Dec;13(3):456-461. Epub 2019 Oct 30.

Department of Allergy and Immunology, University of Missouri Kansas City School of Medicine, Kansas City, Missouri, USA.

Erythema nodosum is a delayed-type hypersensitivity reaction with an unknown trigger in the majority of cases. It is characterized by the development of erythematous tender nodules on the shins. Septal panniculitis without vasculitis is a characteristic histopathological finding. Read More

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http://dx.doi.org/10.1159/000503894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873087PMC
October 2019

An autopsy case of sudden unexpected death with loxoprofen sodium-induced allergic eosinophilic coronary periarteritis.

Cardiovasc Pathol 2020 Jan - Feb;44:107154. Epub 2019 Oct 12.

Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan. Electronic address:

Although the cause of eosinophilic coronary periarteritis (ECPA) remains unclear, an allergic background is present in fewer patients than expected. A 50-year-old man with no history of allergy or symptoms suggestive of cardiac or respiratory disorders suddenly died shortly after oral administration of loxoprofen sodium. Autopsy showed eosinophilic coronary periarteritis in three main branches of the coronary arteries, characterized by eosinophil-predominant inflammation without fibrinoid necrosis or granulomatous change in the adventitia and its surroundings of the three main branches of the coronary arteries, in addition to the localized sign of bronchial asthma in the lung. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107154DOI Listing

Unusual presentation of erythema elevatum diutinum in an HIV-positive man with dramatic response to dapsone.

Int J STD AIDS 2019 11 15;30(13):1337-1339. Epub 2019 Nov 15.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1177/0956462419874985DOI Listing
November 2019
1.037 Impact Factor

A Recurrent Case of Cryoglobulin-related Leukocytoclastic Vasculitis with an Unexpected Etiology.

Cureus 2019 Sep 27;11(9):e5783. Epub 2019 Sep 27.

Hospital Medicine, Aspirus Riverview Hospital, Wisconsin Rapids , USA.

We report a 64-year-old man presenting with cutaneous leukocytoclastic vasculitis, the underlying etiology of which was established as hepatitis C infection with associated cryoglobulinemia. This pathophysiologic state presented clinically as recurrent cutaneous vasculitic eruptions with the absence of any other clinical manifestations except for mild ankle swelling and weakness. This case clearly relates the need to consider hepatitis C as a potential etiologic factor in all patients with cutaneous vasculitis, and we suggest that viral hepatitis screening should be done routinely in all patients presenting with cutaneous vasculitis. Read More

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http://dx.doi.org/10.7759/cureus.5783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825495PMC
September 2019

Clinical Phenotypes of Severe Cutaneous Drug Hypersensitivity Reactions.

Curr Pharm Des 2019 ;25(36):3840-3854

Department of Pediatric Allergy and Immunology, University of Health Sciences, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital, Ankara, Turkey.

Drug hypersensitivity reactions are clinically heterogenous ranging from mild to severe. Most drug hypersensitivity reactions are accompanied by cutaneous manifestations. Fever, mucous membrane involvement, large blisters, facial oedema, pustulosis and visceral involvement are clinical features that lead to suspicion of severe adverse drug reactions. Read More

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http://dx.doi.org/10.2174/1381612825666191107162921DOI Listing

An Update on the Management of Severe Cutaneous Drug Hypersensitivity Reactions.

Curr Pharm Des 2019 ;25(36):3881-3901

Department of Pediatric Allergy and Immunology, Mersin University, Faculty of Medicine, Mersin, Turkey.

Severe cutaneous drug hypersensitivity reactions involve of different mechanisms , some of which are life-threatening, such as Stevens-Johnson syndrome/toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, generalized bullous fixed drug eruptions, serum sickness and serum sickness-like reaction and drug-induced vasculitis. These reactions may have substantial morbidity and mortality. In the past years, successive studies have provided new evidence regarding the pathogenesis of some of these severe reactions and revealed that underlying mechanisms are highly variable. Read More

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http://dx.doi.org/10.2174/1381612825666191106115556DOI Listing
June 2020
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Neutrophil Extracellular Traps are Present in Immune-complex-mediated Cutaneous Small Vessel Vasculitis and Correlate with the Production of Reactive Oxygen Species and the Severity of Vessel Damage.

Acta Derm Venereol 2019 10 30. Epub 2019 Oct 30.

Department of Dermatology, American University of Beirut, PO Box 11-0236, Riad El Solh, Beirut, Lebanon.

Formation of neutrophil extracellular traps has been implicated in autoimmunity. However, the presence and clinical relevance of neutrophil extracellular traps in immune-complex-mediated cutaneous small and medium vessel vasculitides has not been investigated. This study retrospectively analysed 72 patients with histology-proven hypersensitivity vasculitis (n = 21), IgA vasculitis (n = 22), urticarial vasculitis (n = 22), erythema elevatum diutinum (n = 3) and polyarteritis nodosa (n = 4). Read More

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http://dx.doi.org/10.2340/00015555-3363DOI Listing
October 2019

A Case of Cutaneous Arteritis Presenting as Infiltrated Erythema in Eosinophilic Granulomatosis With Polyangiitis: Features of the Unique Morphological Evolution of Arteritis as a Diagnostic Clue.

Am J Dermatopathol 2019 Nov;41(11):832-834

Department of Dermatology, Nippon Kokan Hospital, Kanagawa, Japan.

Eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg-Strauss syndrome) is a rare systemic vasculitis affecting small- and medium-sized vasculature, associated with asthma and eosinophilia. Different levels of vasculitis in cutaneous lesions have been observed, including dermal small vessel vasculitis and subcutaneous muscular vessel vasculitis. Although the EGPA-associated small vessel vasculitis described as leukocytoclastic vasculitis can be often found in the documented literature, the features of subcutaneous muscular vessel vasculitis in EGPA-associated cutaneous lesions have been rarely demonstrated clinically and histopathologically in English literature. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001451DOI Listing
November 2019
2 Reads

Dapsone in immunoglobulin A-associated vasculitis.

Eur J Pediatr 2019 12 19;178(12):1913-1914. Epub 2019 Oct 19.

Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.1007/s00431-019-03472-yDOI Listing
December 2019