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    Safety of quadrivalent live attenuated influenza vaccine in subjects aged 2-49years.
    Vaccine 2017 Mar 2;35(9):1254-1258. Epub 2017 Feb 2.
    AstraZeneca, One MedImmune Way, Gaithersburg, MD 20878, United States.
    Background: Quadrivalent live attenuated influenza vaccine (Q/LAIV) was licensed in 2012 and replaced trivalent live attenuated influenza vaccine in the United States during the 2013-2014 influenza season. This study assessed the safety of Q/LAIV in children and adults aged 2-49years.

    Methods: This was a prospective observational cohort study using data collected from Kaiser Permanente Northern California. Read More

    Annular lesions of cutaneous sarcoidosis with granulomatous vasculitis.
    J Cutan Pathol 2017 Jan 24. Epub 2017 Jan 24.
    Department of Dermatology, Kansai Medical University.
    Sarcoidosis is known to be involved in diseases with vasculitis as sarcoid vasculitis. However, vasculitis in cutaneous sarcoidal lesions is extremely rare. Here we describe a case of sarcoidosis with multiple annular skin lesions with granulomatous vasculitis. Read More

    Vancomycin-Associated Hemorrhagic Occlusive Retinal Vasculitis: Clinical Characteristics of 36 Eyes.
    Ophthalmology 2017 Jan 19. Epub 2017 Jan 19.
    Retina Consultants of Houston, Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas.
    Purpose: To expand understanding of presentation, diagnosis, and outcomes of hemorrhagic occlusive retinal vasculitis (HORV).

    Design: Retrospective case series.

    Participants: Thirty-six eyes of 23 patients. Read More

    Leukocytoclastic Vasculitis Secondary to Pyridostigmine (Mestinon): Report of a Possible First Case.
    Perm J 2016 18;21. Epub 2016 Nov 18.
    Consultant in Medicine at The Dunedin Hospital; an Honorary Clinical Senior Lecturer at the University of Otago School of Medicine in Dunedin, New Zealand; Clinical Assistant Professor of Medicine at Stanford University School of Medicine; and a Hospitalist at the Santa Clara Medical Center in CA.
    Introduction: Pyridostigmine is an acetylcholinesterase inhibitor commonly used in the treatment of myasthenia gravis. We describe a patient who developed a rash after recently being started on pyridostigmine and give a general review of leukocytoclastic vasculitis.

    Case Presentation: A 91-year-old man was diagnosed with ocular myasthenia gravis. Read More

    Suppressive influence of seasonal influenza epidemic on Kawasaki disease onset.
    Nihon Rinsho Meneki Gakkai Kaishi 2016 ;39(6):528-537
    Dermatology & Epidemiology Research Institute (DERI).
      Kawasaki disease (KD) is an acute systemic vasculitis presenting as an infantile febrile disease. In Japan, the widespread cedar plantation commenced in 1945 has been correlated with the increased incidences of both KD and allergic rhinitis (pollinosis) since the early 1960s. We previously showed that KD was a pollen-induced, delayed-type hypersensitivity that displays biphasic peaks in both summer and winter. Read More

    Aseptic Lymphocytic-Dominated Vasculitis-Associated Lesions Scores Do Not Correlate With Metal Ion Levels or Unreadable Synovial Fluid White Blood Cell Counts.
    J Arthroplasty 2016 Nov 22. Epub 2016 Nov 22.
    Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois.
    Background: Failed metal-on-metal (MoM) bearings are being increasingly encountered with little information to guide evaluation for aseptic lymphocytic-dominated vasculitis-associated lesions (ALVAL). It is often assumed that elevated metal ion levels correlate with the occurrence of ALVAL. Our purpose was to determine the utility of the erythrocyte sedimentation rate, C-reactive protein, synovial white blood cell count, differential (%PMN), and serum metal ion levels in diagnosing ALVAL. Read More

    Acrally distributed dermatoses: Vascular dermatoses (purpura and vasculitis).
    Clin Dermatol 2017 Jan - Feb;35(1):68-80. Epub 2016 Sep 10.
    Department of Dermatology and Venereology, Tokuda Hospital Sofia, Sofia, Bulgaria.
    Purpuric lesions appear in acral distribution in a variety of conditions and often provide clues to the clinical diagnosis. Purpuric means "hemorrhagic"-that is, the lesions do not blanch from pressure. This review focuses on dermatoses that produce hemorrhagic lesions in acral distribution from the large groups of the vasculitic diseases and their mimics. Read More

    Chronic Localized Fibrosing Leukocytoclastic Vasculitis Associated With Lymphedema, Intralymphatic and Intravascular Lymphocytosis, and Chronic Myelogenous Leukemia: A Case Report of Unilateral Erythema Elevatum Diutinum.
    Am J Dermatopathol 2016 Dec 7. Epub 2016 Dec 7.
    *Department of Pathology, Albany Medical College, Albany, NY; and †Departamento de Dermatología, Area de Dermatopatología, Hospital Luis Vernaza, Guayaquil, Ecuador.
    One of the pathogenic causes of cutaneous inflammatory pseudotumors is chronic localized fibrosing leukocytoclastic vasculitis (CLFLCV), a vasculitic reaction pattern seen in granuloma faciale (GF), a localized vasculitis, and erythema elevatum diutinum (EED), a generalized vasculitis. Patients with myelodysplastic syndromes (MDSs) are at risk for a diverse spectrum of cutaneous neutrophilic dermatoses such as EED. Herein, we report a 74-year-old man who presented with a large ulcerative, fungating tumor affecting the right flexor ankle caused by CLFLCV. Read More

    Cutaneous Manifestations of Multiple Myeloma.
    Indian J Dermatol 2016 Nov-Dec;61(6):668-671
    Department of Skin and VD, SCB Medical College, Cuttack, Odisha, India.
    Multiple myeloma (MM) is a proliferative disorder of plasma cells which produce abnormal immunoglobulin proteins. Skin involvement is rarely found in this disorder. They are either specific or nonspecific lesions. Read More

    Propylthiouracil-Associated Leukocytoclastic Necrotizing Cutaneous Vasculitis: A Case Report and Review of the Literature.
    J Burn Care Res 2016 Nov 11. Epub 2016 Nov 11.
    From the *Department of Surgical Sciences, Division of General Surgery, Vanderbilt University Medical Center, Nashville, Tennessee; †Department of Anesthesiology, Division of Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; ‡Department of Surgery, Division of Burn and Wound Surgery, University of Missouri, Columbia; and §Department of Surgical Sciences, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee.
    The purpose of this case report and review of the literature is to provide an exploration of the clinical symptoms, diagnosis, prevention, and management of propylthiouracil (PTU)-associated vasculitis in the intensive care setting. A PubMed search of the available literature was conducted using the MeSH search terms "propylthiouracil" and "vasculitis." The literature search returned 121 articles. Read More

    Recurrent purpura due to alcohol-related Schamberg's disease and its association with serum immunoglobulins: a longitudinal observation of a heavy drinker.
    J Med Case Rep 2016 Oct 31;10(1):301. Epub 2016 Oct 31.
    Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Evangelisches Krankenhaus Castrop-Rauxel, Academic Teaching Hospital of the University of Duisburg/Essen, Grutholzallee 21, 44577, Castrop-Rauxel, Germany.
    Background: It is unusual for purpura to emerge as a result of drinking alcohol. Such a peculiarity was observed in a 55-year-old man with a 30-year history of heavy alcohol use.

    Case Presentation: The Caucasian patient was studied for 11 years during several detoxification treatments. Read More

    Pulmonary Leukocytoclastic Vasculitis as an Initial Presentation of Myelodysplastic Syndrome.
    Tuberc Respir Dis (Seoul) 2016 Oct 5;79(4):302-306. Epub 2016 Oct 5.
    Department of Internal Medicine, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
    Systemic vasculitis involving the lung is a rare manifestation of myelodysplastic syndrome (MDS), and secondary vasculitis is considered to have poor prognosis. A 44-year-old man presented with fever and dyspnea of 1 month duration. A chest radiograph revealed bilateral multiple wedge shaped consolidations. Read More

    Leukocytoclastic vasculitis associated with hairy cell leukemia at diagnosis: a case report and review of the literature.
    Tumori 2016 Nov 11;102(Suppl. 2). Epub 2016 Nov 11.
    Institute of Hematology L. and A. Seràgnoli, University of Bologna, Bologna - Italy.
    Background: Autoimmune manifestations may occur in patients with hairy cell leukemia (HCL), and some rare cases of polyarteritis nodosa and leukocytoclastic vasculitis have been reported. However, data regarding the treatment of these cutaneous manifestations are lacking, given the rarity of the concomitance of HCL and vasculitic syndromes.

    Case Presentation: We present a 37-year-old man with paraneoplastic leukocytoclastic vasculitis complicating newly diagnosed HCL. Read More

    Approach to cutaneous vasculitides with special emphasis on small vessel vasculitis: histopathology and direct immunofluorescence.
    Curr Opin Rheumatol 2017 Jan;29(1):39-44
    Department of Pathology, Acıbadem University, Istanbul, Turkey.
    Purpose Of Review: The present review will focus on recent publications in cutaneous vasculitides.

    Recent Findings: Some histopathological and clinical features, such as papillary dermal edema, perivascular C3 deposition, clinically evident edema, and lesions above the waist, may point out renal or gastrointestinal involvement in Henoch-Schönlein purpura (HSP). HSP associated with familial Mediterranean fever differs from typical isolated HSP by showing no deposits of IgA, much younger age, and location of the lesions on the face or the trunk. Read More

    A Case of Streptobacillus moniliformis Infection with Cutaneous Leukocytoclastic Vasculitis.
    Acta Med Okayama 2016 Oct;70(5):377-381
    Department of Dermatology, Okayama City Hospital, Okayama 700-8557,
    A 71-year-old man presented with a high fever, polyarthralgia, petechiae and palpable purpura accompanied by livedoid change on his legs and feet. Histopathological findings of the purpura revealed perivascular infiltration of neutrophils, mononuclear cells, and nuclear debris, and extravasation of red cells mainly in the upper dermis: all signs consistent with leukocytoclastic vasculitis. Small vessel thrombi, which are characteristic features of septic vasculopathy, were also observed. Read More

    Cutaneous manifestations in inflammatory bowel disease: a single institutional study of non-neoplastic biopsies over 13 years.
    J Cutan Pathol 2016 Nov 26;43(11):946-955. Epub 2016 Aug 26.
    Department of Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA.
    Background: Skin is commonly affected by extraintestinal manifestations of inflammatory bowel disease (IBD), but a controlled, systematic histopathologic analysis of cutaneous lesions is lacking.

    Methods: A total of 4147 classified IBD [Crohn disease (CD) or ulcerative colitis (UC); 2000-2013] resections were cross referenced with skin biopsies. Associated non-neoplastic skin biopsies were categorized by basic reaction pattern and neutrophilic vs. Read More

    [Uncommon cutaneous presentation of visceral Leishmaniasis associated with HIV].
    Ann Dermatol Venereol 2016 Dec 11;143(12):841-845. Epub 2016 Oct 11.
    Service de maladies infectieuses et tropicales, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France.
    Background: Visceral leishmaniasis is not normally expressed in skin. Herein, we describe the case of an HIV-positive patient who developed two unusual skin manifestations during an episode of visceral leishmaniasis.

    Patients And Methods: A 48-year-old female patient consulted initially for infiltrated purpura of all four limbs. Read More

    Adverse tissue reactions after total hip arthroplasty.
    Ann Diagn Pathol 2016 Aug 18. Epub 2016 Aug 18.
    Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX.
    Hip arthroplasty is commonly performed on patients with debilitating hip disease to relieve symptoms and improve quality of life. Generally, long-term success rates are excellent. However, a subset of patients requires revision due to prosthesis failure. Read More

    Vancomycin-associated Henoch-Schönlein purpura.
    J Infect Chemother 2017 Mar 25;23(3):180-184. Epub 2016 Sep 25.
    Division of Infectious Disease, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA, USA.
    Intravenous vancomycin is a widely used antibiotics, but it causes different types of cutaneous hypersensitivity reactions, ranging from maculopapular rash, red-man syndrome, drug rash with eosinophilia and systemic symptoms, IgA bullous dermatosis, leukocytoclastic vasculitis, Stevens-Johnsons syndrome, to IgE-mediated anaphylaxis. We report an elderly patient with the end-stage renal disease presented with diffuse palpable purpura while receiving IV vancomycin therapy for methicillin-resistant Staphylococcus aureus septicemia. Histopathology of skin biopsy revealed perivascular infiltrates of leukocytoclastic debris with necrosis of the small-sized blood vessels. Read More

    Transbronchial Cryobiopsy in Diffuse Parenchymal Lung Disease: Retrospective Analysis of 74 Cases.
    Chest 2017 Feb 19;151(2):400-408. Epub 2016 Sep 19.
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.
    Background: Diagnostic evaluation of patients with diffuse parenchymal lung disease (DPLD) is best achieved by a multidisciplinary team correlating clinical, radiological, and pathologic features. Surgical lung biopsy remains the gold standard for histopathologic diagnosis of idiopathic interstitial pneumonias. Emerging data suggest an increasing role for transbronchial cryobiopsy (TBC) in DPLD evaluation. Read More

    Exercise-Induced Vasculitis: A Review with Illustrated Cases.
    Am J Clin Dermatol 2016 Dec;17(6):635-642
    Department of Internal Medicine, Hôtel-Dieu, Centre Hospitalier Universitaire de Nantes, 1 place Alexis Ricordeau, 44093, Nantes, France.
    Although exercise-induced vasculitis (EIV) is usually misdiagnosed, it is not uncommon. Occurring mostly after prolonged exercise, especially in hot weather, EIV is an isolated cutaneous vasculitis with stereotypical presentation. This article reviews the clinical characteristics, treatments, and outcomes of EIV based on the published literature. Read More

    Cutaneous leukocytoclastic vasculitis due to amoxicillin hypersensitivity.
    Ann Allergy Asthma Immunol 2016 Oct 31;117(4):446-447. Epub 2016 Aug 31.
    Allergy Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Gregorio Marañón Health Research Institute (IiSGM), Madrid, Spain; Biomedical Research Network and Rare Diseases (CIBERER) - U761, Madrid, Spain.

    Leukocytoclastic vasculitis in children: clinical characteristics, subtypes, causes and direct immunofluorescence findings of 56 biopsy-confirmed cases.
    J Eur Acad Dermatol Venereol 2016 Aug 31. Epub 2016 Aug 31.
    Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
    Background: Leukocytoclastic vasculitis (LCV) in children is a complex group of conditions.

    Objectives: This study presents the demographics, clinical features, direct immunofluorescence (DIF) results and suspected aetiologies of 56 biopsy-confirmed cases of leukocytoclastic vasculitis in children.

    Methods: Retrospective review of 56 children seen at Mayo Clinic in Rochester, Minnesota, from 1993 to 2013 with clinical features and cutaneous biopsy consistent with LCV. Read More

    Clinicopathologic correlation of 282 leukocytoclastic vasculitis cases in a tertiary hospital: a focus on direct immunofluorescence findings at the blood vessel wall.
    Immunol Res 2016 Aug 16. Epub 2016 Aug 16.
    Department of Dermatology, Hospital das Clínicas, University of São Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, 255, São Paulo, SP, 05403-000, Brazil.
    This is the largest direct immunofluorescence (DIF) analysis of patients with histology-proven cutaneous leukocytoclastic vasculitis (LCV). To establish the correlation of deposition of immune complexes at the blood vessel walls with underlying causes and prognosis of LCV, we performed a retrospective study from January 2007 to December 2014. The patients are followed at the Department of Dermatology, Hospital Das Clínicas da Faculdade de Medicina da Universidade de São Paulo, a tertiary hospital at São Paulo, Brazil. Read More

    Monoclonal gammopathy of cutaneous significance: review of a relevant concept.
    J Eur Acad Dermatol Venereol 2017 Jan 8;31(1):45-52. Epub 2016 Aug 8.
    Faculté de Médecine, Université de Strasbourg et Clinique Dermatologique, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
    Some dermatologic entities are strongly associated with the presence of a monoclonal gammopathy. They should be referred to as monoclonal gammopathy of cutaneous significance (MGCS). A short review of the main entities that fit into the spectrum of MGCS is provided. Read More

    Complement C3 is expressed by mast cells in cutaneous vasculitis and is degraded by chymase.
    Arch Dermatol Res 2016 Oct 27;308(8):575-84. Epub 2016 Jul 27.
    Department of Dermatology, Kuopio University Hospital, University of Eastern Finland, P.O. Box 100, 70029, Kuopio, Finland.
    The complement factor C3 and chymase released from tryptase(+), chymase(+) mast cells may be involved in the pathogenesis of cutaneous leukocytoclastic vasculitis. To study whether mast cells contain C3 in vasculitis and whether chymase interacts with C3, cryosections from vasculitis biopsies were double-stained histochemically for C3c in tryptase(+) mast cells, as well as for chymase and vessel wall C3c, or they were treated with 5 µg/ml rh-chymase for 24 h followed by immunofluorescence (IF) analysis of C3c, IgG, IgM and IgA. The effect of rh-chymase on purified human C3, C3a and IgG was studied using SDS-PAGE electrophoresis and LAD2 mast cell cultures. Read More

    Warfarin-induced leukocytoclastic vasculitis and proteinuria.
    J Family Med Prim Care 2016 Jan-Mar;5(1):160-2
    Department of Internal Medicine, Hematology and Oncology, St Michael's Medical Center, Newark, NJ 07102, USA.
    Warfarin is typically prescribed for patients with thromboembolic diseases and atrial fibrillation. In addition to the complications of bleeding, allergic skin reaction is one of its rare adverse effects. We herein report a case of a 79 year old male patient with leukocytoclastic vasculitis and proteinuria secondary to warfarin. Read More

    Atopic Predilection among Kawasaki Disease Patients: A Cross-Sectional Study of 1,187,757 Teenagers.
    Int Arch Allergy Immunol 2016 21;170(2):92-6. Epub 2016 Jul 21.
    Department of Plastic and Reconstructive Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
    Background: Kawasaki disease (KD) is an acute, systemic vasculitis in children, with an etiology that is not completely understood. It is assumed that the development of KD is mediated by an immunologic response. Several reports from East Asia have found a higher prevalence of atopic diseases among patients with KD, but a large-scale study of a non-Asian population regarding this correlation is still lacking. Read More

    Etiologies and prognostic factors of leukocytoclastic vasculitis with skin involvement: A retrospective study in 112 patients.
    Medicine (Baltimore) 2016 Jul;95(28):e4238
    aService de médecine interne et immunologie clinique bService de médecine interne et maladies systémiques cService de dermatologie dLaboratoire d'anatomopathologie eService de pneumologie fService de maladies infectieuses, CHU François Mitterrand, Dijon, France.
    In this study, outcomes of patients with leukocytoclastic vasculitis (LCV) were analyzed focusing on clinical, histopathology and laboratory findings, relapses, and survival.Data from patients with cutaneous vasculitis diagnosed between January 1, 2000, and December 31, 2010, at Dijon University Hospital (France) were retrospectively reviewed. LCV was defined as perivascular neutrophilic infiltrate, endothelial cell nuclear swelling, extravasation of red blood cells, and/or fibrin deposition in vessels. Read More

    Comparative histological analysis of drug-induced maculopapular exanthema and DRESS.
    J Eur Acad Dermatol Venereol 2016 Dec 16;30(12):2085-2090. Epub 2016 Jul 16.
    Drug Allergy Unit-CCR2A, Department of Allergy and Clinical Immunology, CHU Lyon-Sud, Pierre-Bénite, France.
    Background: Cutaneous adverse drug reactions frequently present as a benign maculopapular exanthema (MPE) with a rapid healing. Sometimes systemic signs are present, which could represent a more severe or systemic MPE (sMPE) or even be the initial phase of a drug reaction with eosinophilia and systemic symptoms (DRESS). Histopathology associated with MPE, sMPE and DRESS has not been well characterized. Read More

    Sudden unexpected death due to severe pulmonary and cardiac sarcoidosis.
    Forensic Sci Med Pathol 2016 Sep 5;12(3):319-23. Epub 2016 Jul 5.
    Medico-Legal and Pathological-Anatomical Department of Health Care Surveillance Authority, Letná 47, 040 01, Kosice, Slovak Republic.
    In this paper we report the autopsy findings of a 57 year old woman who died unexpectedly at home. She had been complaining of shortness of breath, episodes of dry coughing, and nausea. Her past medical and social history was unremarkable. Read More

    Azathioprine therapy for steroid-resistant Henoch-Schönlein purpura: a report of 6 cases.
    Pediatr Rheumatol Online J 2016 Jun 23;14(1):37. Epub 2016 Jun 23.
    Department of Pediatrics, Division of Rheumatology, Washington University School of Medicine, One Children's Place, Campus Box 8116, St. Louis, MO, 63110, USA.
    Background: A small percentage of children with Henoch-Schönlein purpura (HSP) develop a chronic form of the disease that often requires prolonged corticosteroid therapy. Disease modifying anti-rheumatic agents (DMARDs) or biologics have been successfully used to treat those refractory cases. Azathioprine is a DMARD that has been reported to be effective in HSP nephritis and in adult cutaneous leukocytoclastic vasculitis, a condition with cutaneous histology similar to HSP. Read More

    Immunoglobulin A Vasculitis Complicated with Clostridium difficile Infection: a Rare Case Report and Brief Review of the Literature.
    J Gastrointestin Liver Dis 2016 Jun;25(2):235-8
    Gr. T. Popa University of Medicine and Pharmacy;St. Spiridon Emergency Hospital, Institute of Gastroenterology and Hepatology, Iasi, Romania.
    Immunoglobulin A (IgA) vasculitis, formerly called Henoch-Schönlein purpura, is a leukocytoclastic type of vasculitis affecting small vessels with a deposition of immune IgA complexes, clinically characterized by the classic tetrad of nonthrombocytopenic palpable purpura, arthralgia (or arthritis), and gastrointestinal and renal involvement. Although the cause of the disease remains unknown, immune complexes of IgA and unidentified antigens seem to play a central pathogenic role. The diagnosis is easily established in the presence of purpura, but may be challenging in its absence, especially when colicky abdominal pain precedes the cutaneous lesions. Read More

    Lumbar Swelling as the Unusual Presentation of Henoch-Schonlein Purpura in a Child.
    Balkan Med J 2016 May 1;33(3):360-2. Epub 2016 May 1.
    Department of Radiology, Haseki Training and Research Hospital, İstanbul, Turkey.
    Background: Henoch-Schönlein Purpura (HSP) is a systemic hypersensitivity disease of unknown cause that is characterized by a purpuric rash and systemic manifestations, such as colicky abdominal pain, polyarthralgia, and acute glomerulonephritis. Common complications of HSP that lead to surgical intervention include intussusception, perforation, necrosis, and massive gastrointestinal bleeding. Unusual clinical manifestations of HSP may include edema of the scrotum and eyes. Read More

    Palisaded neutrophilic and granulomatous dermatitis - cutaneous manifestation of Lyme disease or connected with CTD? Case report.
    Ann Agric Environ Med 2016 Jun;23(2):384-6
    Department of Dermatology, Jagiellonian University Medical College, Cracow, Poland.
    Introduction: Palisaded neutrophilic and granulomatous dermatitis (PNGD) are terms which include such diseases as rheumatoid nodules, Churg-Strauss granuloma, and interstitial granulomatous dermatitis with arthritis. This heterogeneous group was first described in 1965. It is associated with immunological diseases. Read More

    Leukocytoclastic vasculitis and infection. Report of a case.
    Reumatol Clin 2016 Jun 1. Epub 2016 Jun 1.
    Hospital Rafael Méndez, Lorca, Murcia, España.
    Leukocytoclastic vasculitis is the most common cause of cutaneous vasculitis in clinical practice. Its causes are various, among which are certain infections. We report the case of a man (28 years old) who debuted with vasculitic lesions in inferior members compatibles leukocytoclastic vasculitis on pathology. Read More

    Levamisole-Adulterated Cocaine Nephrotoxicity:  Ultrastructural Features.
    Am J Clin Pathol 2016 May;145(5):720-6
    Department of Pathology
    Objectives: The issue of levamisole-adulterated cocaine is emerging as a rapidly growing public health concern due to an increasing number of reports describing its role in cutaneous vasculitis and agranulocytosis. Of note, levamisole is recognized as a contaminant in 69% of the cocaine used within the United States.

    Methods: We describe a patient who was a chronic cocaine user and developed systemic vasculitis characterized by polyarthralgia, bullous skin lesions, agranulocytosis, and antineutrophil cytoplasmic antibody-positive rapidly progressive glomerulonephritis. Read More

    Treatment of nodular vasculitis with colchicine.
    Australas J Dermatol 2016 Jun 1. Epub 2016 Jun 1.
    Department of Dermatology, St Vincent's Hospital, Melbourne, Victoria, Australia.
    Nodular vasculitis (NV) refers to a chronic relapsing lobular panniculitis that is thought to be a hypersensitivity reaction to antigenic triggers. While it is commonly associated with tuberculosis, in many cases no underlying cause is found and the condition is difficult to manage. Here, we report three patients with refractory idiopathic NV effectively treated with colchicine, leading to a significant improvement or complete resolution of their symptoms. Read More

    Acute Hemorrhagic Edema of Infancy: Still a Challenge for the Pediatrician.
    Pediatr Emerg Care 2016 May 30. Epub 2016 May 30.
    From the Departments of *Pediatrics, and †Pediatric Emergency, University of Turin, Regina Margherita Children's Hospital, Turin, Italy.
    We report a case of acute hemorrhagic edema of infancy (AHEI) occurred in an 11-month-old male infant after upper respiratory tract infection. The onset was dramatic with petechiae, ecchymosis, and annular, nummular, or targetoid purpuric plaques on the extremities, face, and ears. Acute hemorrhagic edema of infancy is a benign form of leukocytoclastic vasculitis that typically affects children between 4 and 24 months of age. Read More

    Hypersensitivity pneumonitis associated with azathioprine therapy in a patient with granulomatosis with polyangiitis.
    Rheumatol Int 2016 Jul 7;36(7):1027-32. Epub 2016 May 7.
    Division of Pulmonary and Critical Medicine, Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.
    Granulomatosis with polyangiitis (GPA), an autoimmune disease characterized by inflammatory granulomas and necrotizing small-vessel vasculitis, primarily affects the respiratory tract and kidneys. Azathioprine (AZA) is a purine analog that is commonly used for maintaining GPA remission after induction therapy with cyclophosphamide. While the dose-dependent side effects of AZA are common and well known, hypersensitivity reactions such as pulmonary toxicity are rare. Read More

    Cocaine/levamisole-induced systemic vasculitis with retiform purpura and pauci-immune glomerulonephritis.
    Braz J Med Biol Res 2016 26;49(5):e5244. Epub 2016 Apr 26.
    Serviço de Nefrologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
    Levamisole has been increasingly used as an adulterant of cocaine in recent years, emerging as a public health challenge worldwide. Levamisole-associated toxicity manifests clinically as a systemic vasculitis, consisting of cutaneous, hematological, and renal lesions, among others. Purpura retiform, cutaneous necrosis, intravascular thrombosis, neutropenia, and less commonly crescentic nephritis have been described in association with anti-neutrophil cytoplasmic antibodies (ANCAs) and other autoantibodies. Read More

    Posterior Spinal Artery Aneurysm Presenting with Leukocytoclastic Vasculitis.
    J Cerebrovasc Endovasc Neurosurg 2016 Mar 31;18(1):42-7. Epub 2016 Mar 31.
    Department of Neurosurgery, New York University School of Medicine, New York, NY, USA.
    Rupture of isolated posterior spinal artery (PSA) aneurysms is a rare cause of subarachnoid hemorrhage (SAH) that presents unique diagnostic challenges owing to a nuanced clinical presentation. Here, we report on the diagnosis and management of the first known case of an isolated PSA aneurysm in the context of leukocytoclastic vasculitis. A 53-year-old male presented to an outside institution with acute bilateral lower extremity paralysis 9 days after admission for recurrent cellulitis. Read More

    Azathioprine-induced bullous Sweet's syndrome: a rare association.
    BMJ Case Rep 2016 Apr 18;2016:10.1136/bcr-2016-215192. Epub 2016 Apr 18.
    Department of Dermatology & Venereology, Midnapore Medical College & Hospital, Midnapore, West Bengal, India.
    A 52-year-old man presented with high-grade fever, headache and painful vesicular skin rash involving the upper trunk and upper extremities, 8 days after initiation of chemotherapy with azathioprine (50 mg/day), which had been prescribed for acral vitiligo. There was neither any history of preceding respiratory or gastrointestinal tract infection, nor was the patient known to have malignancy, drug hypersensitivity, inflammatory bowel disease, vasculitis or other autoimmune disease. Laboratory results revealed leucocytosis with neutrophilia and markedly elevated acute phase reactants. Read More

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