3,636 results match your criteria Hypersensitivity Vasculitis


An unusually "complex" glomerulonephritis.

Proc (Bayl Univ Med Cent) 2022 13;35(4):531-533. Epub 2022 May 13.

Division of Rheumatology, The University of Texas Southwestern Medical Center, Dallas, Texas.

A 53-year-old man with granulomatosis with polyangiitis presented with fever and acute kidney injury with nephrotic-range proteinuria following the second dose of the mRNA COVID-19 vaccine. Renal biopsy revealed an unexpected immune complex-glomerulonephritis (IC-GN) without vasculitis. Further workup found the patient to have HIV that was unmasked following the treatment of IC-GN. Read More

View Article and Full-Text PDF

Cutaneous leukocytoclastic vasculitis following COVID-19 vaccination with Ad26.COV2.S vaccine: a case report and literature review.

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):83-87

Department of Dermatovenereology, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Cutaneous vasculitis is a recognized and potentially serious adverse event of immunization with several vaccines, and COVID-19 vaccines are no exception. We present a case of cutaneous leukocytoclastic vasculitis occurring 17 days after inoculation with adenoviral vector vaccine (Ad26.COV2. Read More

View Article and Full-Text PDF

Case report of sotalol Induced IgA Vasculitis.

Curr Rheumatol Rev 2022 Jun 23. Epub 2022 Jun 23.

Internal Medicine Department, Amita Health St Joseph Hospital, Chicago, Illinois, USA.

Background IgA vasculitis is the most common form of systemic vasculitis in children but can occur in adults. Inciting antigens include infections, drugs, foods, insect bites, and immunizations. Antibiotics and tumor necrosis factor (TNF) alpha inhibitors are the most common class of drugs that cause IgA vasculitis. Read More

View Article and Full-Text PDF

Vasculitis flare after COVID-19: report of two cases in patients with preexistent controlled IgA vasculitis and review of the literature.

Rheumatol Int 2022 Jun 13. Epub 2022 Jun 13.

Rheumatology Unit, Hospital Universitario de La Princesa, IIS-Princesa, Diego de León 62, 28006, Madrid, Spain.

COVID-19 has been related to several autoimmune diseases, triggering the appearance of autoantibodies and endothelial dysfunction. Current evidence has drawn attention to vasculitis-like phenomena and leukocytoclastic vasculitis in some COVID-19 patients. Moreover, it has been hypothesized that COVID-19 could induce flares of preexisting autoimmune disorders. Read More

View Article and Full-Text PDF

Amiodarone-induced cutaneous leukocytoclastic vasculitis: a case report and a review of the literature.

Clin Rheumatol 2022 Jun 2. Epub 2022 Jun 2.

Department of Dermatology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.

Amiodarone can be used in a variety of arrhythmias. Given its widespread use, the probability of clinicians encountering its cutaneous adverse effects is high. A few cases of amiodarone-induced cutaneous vasculitis were reported in the literature, probably because it is underdiagnosed in clinical practice. Read More

View Article and Full-Text PDF

[HLA-B58.01 and allopurinol hypersensitivity renal vasculitis in a Chinese patient].

Rev Med Interne 2022 May 20. Epub 2022 May 20.

Centre de néphrologie et transplantation rénale, AP-HM, CHU de la Conception, 147, boulevard Baille, 13005 Marseille, France; C2VN, Inserm 1263, Institut national de la recherche agronomique (INRA) 1260, faculté de Pharmacie, Marseille, France.

Introduction: Allopurinol, widely used in the treatment of hyperuricemia and gout, has been shown to cause severe cutaneous reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, as well as systemic reactions such as DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms). The HLA-B*5801 allele is known to be a risk factor for severe cutaneous manifestations of hypersensitivity to allopurinol, mostly in Asian populations.

Observation: We report the observation of a 47-year-old Chinese patient, with no previous medical history, carrying the HLA-B*5801 allele, who developed an isolated allopurinol hypersensitivity necrotizing renal vasculitis without cutaneous manifestations. Read More

View Article and Full-Text PDF

Cutaneous manifestations of antineutrophil cytoplasmic antibody-associated vasculitis (AAV): a concise review with emphasis on clinical and histopathologic correlation.

Int J Dermatol 2022 May 22. Epub 2022 May 22.

Departments of Dermatology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) comprises a group of small vessel vasculitides grouped by commonalities of clinical manifestations and ANCA testing. Skin findings are not uncommon, although there is considerable overlap and many times nonspecificity. In general, patients with skin findings tend to have more significant systemic illness, and skin lesions most often develop simultaneously or following onset of systemic symptoms. Read More

View Article and Full-Text PDF

Ceftriaxone-induced leukocytoclastic vasculitis: a case report and literature review of antibiotic-induced leukocytoclastic vasculitis.

J Int Med Res 2022 May;50(5):3000605221097768

Department of Internal Medicine, King Abdullah Medical City, Makkah, Kingdom of Saudi Arabia.

Leukocytoclastic vasculitis (hypersensitivity vasculitis) is defined as small blood vessel inflammation with skin or other systemic manifestations due to infections, drugs, or neoplastic disease. This clinical case report highlights an association between ceftriaxone and leukocytoclastic vasculitis in a 49-year-old female patient with a history of penicillin allergy, on mirtazapine for anxiety disorder. Articles concerning antibiotic-induced leukocytoclastic vasculitis are also reviewed. Read More

View Article and Full-Text PDF

Cerebral vasculitis due to nickel hypersensitivity: a case of intracranial "device syndrome".

Neurol Sci 2022 May 18. Epub 2022 May 18.

Department of Neurology, Stroke Unit, "SS Annunziata" Hospital, Chieti, Italy.

View Article and Full-Text PDF

[Cutaneous Vasculitides - Clinical Manifestations, Diagnosis, and Aetiology].

Ther Umsch 2022 Jun;79(5):238-246

Servizio di Dermatologia EOC, Ospedale San Giovanni, Bellinzona.

Cutaneous Vasculitides - Clinical Manifestations, Diagnosis, and Aetiology Vasculitides are a heterogeneous group of diseases that are classified differently, for example according to the size of the affected vessel or according to primary and secondary causes. The skin is most frequently affected; it can be involved both as single organ vasculitis and in the context of systemic forms. The combination of skin lesions, their anatomical location and information on the time course provide clues for a differential diagnosis. Read More

View Article and Full-Text PDF

Leukocytoclastic Vasculitis Induced by Immune Checkpoint Inhibition in a Patient With Advanced Renal Cell Carcinoma.

Oncology (Williston Park) 2022 05;36(5):316-320

A Mexican woman, aged 60 years, presented with fevers and abdominal pain. She had initially presented to an outside emergency department with weakness, malaise, nausea, vomiting, tachycardia to 110s, and fever to 102 °F. Her medical history was relevant for hypertension, prediabetes, and tobacco use (4-5 cigarettes/day for 12 years). Read More

View Article and Full-Text PDF

Cutaneous manifestations of ANCA-associated vasculitis: a retrospective review of 211 cases with emphasis on clinicopathologic correlation and ANCA status.

Int J Dermatol 2022 May 16. Epub 2022 May 16.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA.

Background: ANCA-associated vasculitis (AAV) may present a wide array of dermatological manifestations. Patients may remain ANCA negative, rendering diagnosis challenging for dermatologists if they depend heavily on ANCA testing to either confirm or rule out AAV.

Objective: To compare clinical and histopathological features of AAV patients with skin lesions who are ANCA positive versus those who are ANCA negative. Read More

View Article and Full-Text PDF

Reactive arthritis following COVID-19 vaccination with BNT162b2.

JAAD Case Rep 2022 Jun 11;24:108-111. Epub 2022 May 11.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York.

View Article and Full-Text PDF

A Case of Tofacitinib-Induced Lymphomatoid Papulosis With Ocular Involvement.

Am J Dermatopathol 2022 Jul 4;44(7):523-525. Epub 2022 May 4.

Department of Dermatology, Oregon Health and Science University, Portland, OR.

Abstract: Janus kinase (JAK) inhibitors are being prescribed with increasing regularity in dermatology. We report on a patient who initiated treatment with tofacitinib for refractory erythema elevatum diutinum and subsequently developed a novel cutaneous outbreak characterized by firm violaceous papules on the trunk and extremities along with conjunctival injection and periorbital inflammation. Biopsy of affected tissue from both the cutaneous and ophthalmologic sources demonstrated increased numbers of CD30+ large atypical cells amid a mixed inflammatory cell infiltrate, consistent with lymphomatoid papulosis. Read More

View Article and Full-Text PDF

Urticarial vasculitis in a young woman with Graves hyperthyroidism.

CMAJ 2022 May;194(17):E612

Department of Dermatology (Hung, Chen), Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; Drug Hypersensitivity Clinical and Research Center (Hung, Chen), Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; College of Medicine (Hung, Chen), Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Immunology (Chen), College of Medicine, National Taiwan University, Taipei City, Taiwan

View Article and Full-Text PDF

Granulocyte colony-stimulating factor as a cause of acute leucocytoclastic vasculitis with anti-Ro and anti-La antibodies.

BMJ Case Rep 2022 Apr 22;15(4). Epub 2022 Apr 22.

Department of Dermatology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Granulocyte colony-stimulating factor (G-CSF) administration is associated with a diverse range of cutaneous sequelae. Serious dermatological side effects of G-CSF include the development of Sweet's syndrome and exacerbations of pre-existing inflammatory disorders such as psoriasis. Here, we describe a report of acute leucocytoclastic vasculitis caused by G-CSF therapy associated with anti-Ro and anti-La antibodies in a patient with multiple myeloma. Read More

View Article and Full-Text PDF

Current perspective of progressive-fibrosing interstitial lung disease.

Authors:
Tomoo Kishaba

Respir Investig 2022 Apr 14. Epub 2022 Apr 14.

Department of Respiratory Medicine, Okinawa Chubu Hospital, Miyazato 281, Uruma City, Okinawa 〒904-2293, Japan. Electronic address:

Interstitial lung disease (ILD) is a parenchymal lung disease and restrictive disorder that presents as diffuse infiltrative shadows. The initial diagnosis of ILD is important because management strategies depend on the disease pathogenesis. Connective-tissue disease (CTD)-associated ILD including rheumatoid arthritis (RA), systemic sclerosis (SSc) requires a thorough evaluation of chronic respiratory symptoms such as non-productive cough and exertional dyspnea, as well as physical findings. Read More

View Article and Full-Text PDF

SEVERE LEUKOCYTOCLASTIC VASCULITIS AFTER COVID-19 VACCINATION - CAUSE OR COINCIDENCE? CASE REPORT AND LITERATURE REVIEW.

Georgian Med News 2022 Mar(324):134-139

Städtisches Klinikum Dresden, 1Department of Dermatology and Allergology; Germany Städtisches Klinikum Dresden, 1Department of Dermatology and Allergology; Germany.

Vaccination has been the most powerful tool to fight the COVID-19 pandemic while the specific treatment options in clinical practice have been under review for approval and authorization by regulatory bodies. After registration of different vaccines, it is important to ensure a post-marketing surveillance to identify potential risks not observed in controlled trials. Authors report on the case of an 80-year-old male patient who developed severe leukocytoclastic vasculitis of skin and oral mucous membrane after receiving the second dose of COVID-19 mRNA vaccine. Read More

View Article and Full-Text PDF

Urticarial vasculitis: Clinical and laboratory findings with a particular emphasis on differential diagnosis.

J Allergy Clin Immunol 2022 Apr;149(4):1137-1149

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy; Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address:

Urticarial vasculitis (UV) is a rare cutaneous vasculitis of small vessels characterized by recurrent episodes of wheal-like lesions that tend to last more than 24 hours, healing with a residual ecchymotic postinflammatory hyperpigmentation. The histopathologic pattern of UV is that of leukocytoclastic vasculitis, consisting of fibrinoid necrosis of dermal vessels' walls and neutrophil-rich perivascular inflammatory infiltrates. Although its etiopahogenesis remains still undefined, UV is now regarded as an immune complex-driven disease with activation of the complement cascade, leading to exaggerated production of anaphylatoxins that are responsible for neutrophil recruitment and activation. Read More

View Article and Full-Text PDF

Extensive cutaneous leukocytoclastic vasculitis after Sinopharm vaccine: Case report and review of the literature.

J Cutan Pathol 2022 Mar 30. Epub 2022 Mar 30.

Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Cutaneous leukocytoclastic vasculitis (LCV) has been reported as a rare form of cutaneous reaction to different SARS-Cov-2 vaccines. Herein, we present the first case of cutaneous LCV following BBIBP-CorV (Sinopharm) vaccine that occurred in a female patient with no prior comorbidities. A literature review about similar cases following different COVID-19 vaccines is discussed. Read More

View Article and Full-Text PDF

Palpable purpuric eruption mimicking vasculitis following avapritinib.

JAAD Case Rep 2022 Apr 14;22:89-92. Epub 2022 Feb 14.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article and Full-Text PDF

Clinical Manifestations and Outcomes of Tubercular Uveitis in Taiwan-A Ten-Year Multicenter Retrospective Study.

Medicina (Kaunas) 2022 Mar 3;58(3). Epub 2022 Mar 3.

Department of Ophthalmology, Taipei Tzu Chi Hospital, Tri-Service General Hospital, Taipei 231, Taiwan.

: This 10-year multicenter retrospective study reviewed the clinical manifestations, diagnostic tests, and treatment modalities of tubercular uveitis (TBU), including direct infection and indirect immune-mediated hypersensitivity to mycobacterial antigens in Taiwan. : This retrospective chart review of patients with TBU was conducted at 11 centers from 1 January 2008 to 31 December 2017. We used a multiple regression model to analyze which factors influenced best-corrected visual acuity (BCVA) improvement. Read More

View Article and Full-Text PDF

SARS-CoV-2 vaccination-induced cutaneous vasculitis: Report of two new cases and literature review.

Dermatol Ther 2022 Jun 25;35(6):e15458. Epub 2022 Mar 25.

Department of Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Currently the most powerful tool in combating the COVID-19 pandemic is vaccination against SARS-CoV-2. A growing percentage of the world's population is being vaccinated. Various vaccines are worldwide on the market. Read More

View Article and Full-Text PDF

Leukocytoclastic Vasculitic Rash Following Second Dose of Moderna COVID-19 Vaccine.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096211066283

Icahn School of Medicine at Mount Sinai-Elmhurst Hospital Center, New York, NY, USA.

The immunization against coronavirus disease (COVID-19) via vaccination serves as a significant milestone in the fight against the pandemic. Rapid introduction of various COVID-19 vaccines to stem the spread of virus has researchers scrambling to document the adverse effects left in its wake. Thus far, there have been singular examples of cutaneous vasculitis associated with COVID-19. Read More

View Article and Full-Text PDF

Lymphocyte Subset Ratio Cannot Diagnose Immune Failure of a TKA.

J Arthroplasty 2022 Jul 9;37(7):1364-1368. Epub 2022 Mar 9.

Department of Orthopaedic Surgery, Harbor-UCLA Medical Center, Torrance, CA; Joint Replacement Institute at St. Vincent Medical Center, Los Angeles, CA.

Background: Up to 20% of patients are dissatisfied following total knee arthroplasty (TKA), most often due to pain and/or stiffness. The differential diagnosis includes immune reaction to the prosthesis. However, there is no consensus on diagnostic criteria for immune failure, an allergic reaction, to a TKA. Read More

View Article and Full-Text PDF

Cutaneous leukocytoclastic vasculitis secondary to COVID-19 infection leading to extensive skin necrosis.

Clin Dermatol 2022 Mar 4. Epub 2022 Mar 4.

Department of Dermatology, University Hospital of Basel, Basel, Switzerland.

A wide range of extrapulmonary manifestations in patients with COVID-19 has been reported during the ongoing pandemic, thus making the clinical spectrum of this new disease very heterogeneous. While COVID-19-associated vasculitis and vasculopathy have been described, cutaneous leukocytoclastic vasculitis (cLcV) due to SARS-CoV-2 has rarely been reported, and if it has, with relatively mild courses. We present the case of a 93-year-old man who, after having survived classic COVID-19 infection, developed a fulminant cLcV leading to extensive skin necrosis and tissue damage that resulted in his death. Read More

View Article and Full-Text PDF

Systemic lupus erythematosus/ANCA-associated vasculitis overlap: An explanation for atypical lupus manifestation.

Lupus 2022 Apr 4;31(4):495-499. Epub 2022 Mar 4.

Faculty of Medicine, 27964Pontificia Universidad Javeriana, Bogotá, DC, Colombia.

The coexistence of systemic lupus erythematosus (SLE) and ANCA-associated vasculitis (AAV) as an overlapping syndrome is not common. Here, we report a case of a 33-year-old woman, with recent SLE diagnosis due to skin, kidney, articular, and immunologic compromise, in whom a chest CT scan showed bilateral nodules, consolidations, and tree-in-bud pattern; thoracoscopic lung biopsy revealed diffuse non-caseating granulomas, without other features of sarcoid, organizing pneumonia, or hypersensitivity pneumonitis with high positive p-ANCA titers. Overlap between SLE and AAV was a possible explanation for lupus granulomatous pneumonitis, and for this reason, a multidisciplinary meeting was held to evaluate complex patients with interstitial lung diseases patients. Read More

View Article and Full-Text PDF

Acro-ischemic lesions in COVID-19 patients: A case series.

J Cosmet Dermatol 2022 May 14;21(5):1822-1829. Epub 2022 Mar 14.

Department of Plastic Surgery, Malatya Training and Research Hospital, Malatya, Turkey.

COVID-19 is a systemic disease characterized by vascular damage, increased inflammation, and hypercoagulability. Acral ischemic lesions occur as a result of increased inflammation and cutaneous thrombosis. Skin lesions can sometimes be the only symptom of COVID-19. Read More

View Article and Full-Text PDF

Therapeutic plasma exchange for the management of a type III hypersensitivity reaction and suspected immune-mediated vasculitis assumed to be caused by human albumin administration in a dog.

J Vet Emerg Crit Care (San Antonio) 2022 Mar 2. Epub 2022 Mar 2.

Department of Small Animal Internal Medicine, The Veterinary Teaching Hospital, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.

Objective: To describe the successful treatment of a life-threatening type III hypersensitivity reaction suspected to have been related to human serum albumin (HSA) administration in a dog with therapeutic plasma exchange (TPE).

Case Summary: A 3-year-old neutered male mixed breed dog was suspected to have developed immune-mediated vasculitis 2 weeks after the administration of HSA (740 mg/kg) for the management of hypoalbuminemia resulting from septic peritonitis. The dog was presented with fever, edema, hypoalbuminemia (26 g/L [2. Read More

View Article and Full-Text PDF

The Hidden Cause of Maculopapular Rash in Interleukin-12 Deficiency.

Cureus 2022 Jan 19;14(1):e21415. Epub 2022 Jan 19.

Pathology and Laboratory Medicine, King Abdulaziz Medical City, Ministry of National Guard ‑ Health Affairs, Riyadh, SAU.

Interleukin-12 RB1 (IL12RB1) deficiency falls under the Mendelian susceptibility to mycobacterial disease. It is a rare genetic disease with autosomal recessive inheritance. It is characterized by recurrent infections with otherwise weak bacteria, such as mycobacteria and . Read More

View Article and Full-Text PDF
January 2022