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    1 OF 61

    Dapsone treatment is efficient against persistent cutaneous and gastrointestinal symptoms in children with Henoch-Schönlein purpura.
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2017 Nov 2. Epub 2017 Nov 2.
    Department of Pediatrics, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic.
    Background: Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis involving the capillaries and by the deposition of IgA immune complexes. An association between HSP and atypical bacteria is uncommon in children.

    Methods And Results: Here we report three cases of children, aged 5, 4 and 16 years, who were diagnosed with HSP associated with Mycoplasma pneumoniae or Chlamydia pneumoniae infection. Read More

    [Acute hemorrhagic edema of infancy: alarming lesions of a benign condition. Case report].
    Arch Argent Pediatr 2017 12;115(6):e432-e435
    Salud total EPS, Urbanización El Bosque.
    We report a case of acute hemorrhagic edema of infancy in an 18-month-old boy after an episode of otitis media. The clinical presentation begins with skin erythematous macules on the thighs, followed by purpuric lesions in arms, legs, and ankle edema. It was initially interpreted as urticaria, whereby steroids were indicated. Read More

    Leukocytoclastic vasculitis presenting in association with Coxiella burnetii (Q fever); a case report.
    J Cutan Pathol 2017 Oct 13. Epub 2017 Oct 13.
    Department of Pathology and Dermatopathology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, 90027.
    Q fever caused by Coxiella burnetii usually presents asymptomatically or as an undifferentiated febrile disease and rarely as rash or other cutaneous manifestations of the disease. Here we present a 41 year old male complaining of body aches, fevers, nausea, malaise, bilateral knee pain, and vomiting. Clinical examination revealed a notable erythematous blanching rash all over his body. Read More

    Direct immunofluorescence testing in vasculitis-A single institution experience with Henoch-Schönlein purpura.
    J Cutan Pathol 2017 Oct 6. Epub 2017 Oct 6.
    Departments of Pathology and Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio.
    Background: Direct immunofluorescence (DIF) panels (IgG, IgA, IgM, C3 and fibrinogen) are ordered for clinically suspected vasculitis, with frequently negative results.

    Methods: Cases submitted for DIF and histology (2010-2014) with "vasculitis" in the clinical data were examined, and the electronic medical record reviewed for clinical suspicion of Henoch-Schönlein purpura (HSP). Peri/intravascular IgA was considered "positive," other reactants "non-specific" and no immunoreactivity "negative. Read More

    Outline of guidelines for the management of vasculitis and vascular disorders in Japan, 2016 revised edition.
    J Dermatol 2017 Oct 6. Epub 2017 Oct 6.
    Department of Dermatology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
    The proposal by the 1994 International Chapel Hill Consensus Conference on the Nomenclature of Systemic Vasculitides (CHCC1994) and by the CHCC2012 markedly influenced the classification and way of considering cutaneous vasculitis. In the proposal by the CHCC1994, hypersensitivity angiitis was defined as an equivalent pathological condition to microscopic polyangiitis or cutaneous leukocytoclastic angiitis (CLA), and it was not adopted as a disease name. However, CLA which was positioned as a type of small-vessel vasculitis is only a pathological name. Read More

    Cutaneous leukocytoclastic vasculitis: the role of lymphocytes and related immune markers.
    Postepy Dermatol Alergol 2017 Aug 1;34(4):299-305. Epub 2017 Aug 1.
    Department of Dermatology, Ruhr-University Bochum, Bochum, Germany.
    Introduction: Apart from neutrophils, other immune cells may play a significant pathogenetic role in cutaneous leukocytoclastic vasculitis (CLV).

    Aim: To investigate lymphocytes and related immunological factors in patients with CLV requiring systemic glucocorticosteroid treatment.

    Material And Methods: Fourteen patients with severe idiopathic CLV were treated with systemic prednisolone in a tapered dose regimen. Read More

    Bacterial Endocarditis Presenting as Leukocytoclastic Vasculitis.
    Cureus 2017 Jul 13;9(7):e1464. Epub 2017 Jul 13.
    Internal medicine/ Rheumatology, Arthritis and Rheumatology Clinics of Kansas.
    Subacute bacterial endocarditis can have many different presentations; in rare instances, it can present as leukocytoclastic vasculitis owing to the effect of circulating immune complexes and micro-emboli on the vascular endothelium. A high index of suspicion needs to be maintained to differentiate between infectious vs noninfectious autoimmune vasculitides, keeping in mind that missing a diagnosis can have fatal results. In this case report, we introduce a young female patient who initially presented with a picture of idiopathic autoimmune cutaneous vasculitis delaying the diagnosis of an underlying infective endocarditis with aortic valve involvement. Read More

    Liver chemistry in new-onset Henoch-Schönlein syndrome.
    Ital J Pediatr 2017 Sep 21;43(1):85. Epub 2017 Sep 21.
    Pediatric Emergency Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
    Background: Henoch-Schönlein syndrome is a systemic small-vessel leukocytoclastic vasculitis that usually present with cutaneous, gastrointestinal, articular and renal manifestations. Little is known on liver involvement in this syndrome. This study investigated liver chemistry and creatine kinase in Henoch-Schönlein children. Read More

    Pediatric vasculitis: a single center experience.
    Int J Dermatol 2017 Nov 19;56(11):1130-1138. Epub 2017 Sep 19.
    First Department of Pediatrics, University of Athens, Aghia Sofia Children's Hospital, Athens, Greece.
    Background: Existing studies of children with vasculitis are limited. The aim of this study was to assess the epidemiology, clinical manifestations, laboratory findings, course, and outcome of Greek children presenting with vasculitic rash.

    Methods: The relevant data included in the study were collected retrospectively using a standardized form from children who were admitted into our department between 2003 and 2013, with the provisional diagnosis of vasculitis of the skin. Read More

    Protective Role of Mast Cells in Primary Systemic Vasculitis: A Perspective.
    Front Immunol 2017 23;8:990. Epub 2017 Aug 23.
    Division of Allergy, Clinical Immunology and Rheumatology, Department of Medicine, University of Kansas Medical Center, Kansas City, KS, United States.
    Mast cells are important cells of the immune system. Although traditionally considered as key players in allergic and hypersensitivity reactions, emerging evidence suggests that mast cells have many complex roles in vascular disease. These include regulation of vasodilation, angiogenesis, activation of matrix metalloproteinases, apoptosis of smooth muscle cells, and activation of the renin angiotensin system. Read More

    Cutaneous Manifestations of Small-Vessel Leukocytoclastic Vasculitides in Childhood.
    Clin Rev Allergy Immunol 2017 Aug 24. Epub 2017 Aug 24.
    Pediatric Department of Southern Switzerland, San Giovanni Hospital, 6500, Bellinzona, Switzerland.
    In childhood, cutaneous small-vessel vasculitides include Henoch-Schönlein syndrome, a systemic vasculitis, and Finkelstein-Seidlmayer syndrome, a skin-limited vasculitis. Both Henoch-Schönlein and Finkelstein-Seidlmayer syndromes are seen more frequently in white or Asian compared with black children and occur especially in winter and spring with a male-to-female ratio of approximately 2:1. In everyday clinical practice, both conditions are diagnosed on clinical grounds without histological confirmation. Read More

    Colchicine: an ancient drug with novel applications.
    Br J Dermatol 2017 Aug 18. Epub 2017 Aug 18.
    Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD.
    Colchicine is a historic treatment for gout that has been used for more than a millennium. It is the treatment of choice for Familial Mediterranean Fever and its associated complication, amyloidosis. The 2009 FDA approval of colchicine as a new drug had research consequences. Read More

    Henoch-Schonlein purpura associated with primary active Epstein-Barr virus infection: a case report.
    Pan Afr Med J 2017 11;27:29. Epub 2017 May 11.
    University of Health Sciences, Umraniye Research and Training Hospital, Department of Pediatrics, Istanbul, Turkey.
    Henoch-Schönlein purpura (HSP) is the most common form of childhood vasculitis. Various viral and bacterial infections, drugs, vaccines, food allergy and even insect bites have been considered as triggering factors in pathogenesis of HSP. Epstein-Barr virus (EBV) infection, which is associated with HSP, have been rarely reported. Read More

    Leukocytoclastic Vasculitis and Dermal Perivascular Hemophagocytosis Associated With Adalimumab Therapy for Rheumatoid Arthritis.
    Am J Dermatopathol 2017 Jul 14. Epub 2017 Jul 14.
    Departments of *Dermatology, and†General Medicine/Primary Care Center, Aichi Medical University School of Medicine.
    Tumor necrosis factor (TNF)-α inhibitors target TNF-α to effectively treat autoimmune inflammatory conditions, such as rheumatoid arthritis. However, many cases of cutaneous and systemic vasculitis related to TNF-α inhibitors have been reported in the literature. Here, the authors report the first case of a 61-year-old Japanese woman who developed leukocytoclastic vasculitis with cutaneous perivascular hemophagocytosis, which was related to elevated cytokines and immune complexes after initiating adalimumab for rheumatoid arthritis without evidence of hemophagocytic syndrome and rarely encountered in the skin. Read More

    Making Sense of Metal Allergy and Hypersensitivity to Metallic Implants in Relation to Hand Surgery.
    J Hand Surg Am 2017 Sep 12;42(9):737-746. Epub 2017 Jul 12.
    Department of Orthopedic Surgery, Division of Hand Surgery, Mayo Clinic, Rochester, MN. Electronic address:
    All metals implanted into a biological system undergo some degree of corrosion depending upon its composition. The electrochemical process of corrosion produces free metal ions, which may activate the host's immune system through a variety of mechanisms. Whereas dermal metal hypersensitivity is common, affecting 10% to 15% of the population, the immune reaction from implanted metals is much less common (< 0. Read More

    Possible role of Helicobacter pylori in diseases of dermatological interest.
    J Biol Regul Homeost Agents 2017 APR-JUN;31(2 Suppl. 2):57-77
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

    Leukocytoclastic vasculitis resolution with topical dapsone.
    Cutis 2017 Jun;99(6):426-428
    Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
    Leukocytoclastic vasculitis (LCV) is a disease characterized by inflammation of small vessels presenting with petechiae and palpable purpura. Leukocytoclastic vasculitis often spontaneously resolves within weeks and requires only symptomatic treatment. Chronic or severe disease can require systemic treatment with agents such as colchicine, dapsone, or corticosteroids, which are effective but carry a risk for serious adverse events. Read More

    Cocaine-Levamisole-Induced Vasculitis/Vasculopathy Syndrome.
    Curr Rheumatol Rep 2017 Jun;19(6):36
    Hospital Pablo Tobon Uribe, Calle 78 B # 69-240 consultorio 153, Medellin, Colombia.
    Purpose Of Review: To understand the clinical spectrum of cocaine-levamisole-induced vasculitis. Worldwide recreational drug consumption is high among the adult population from various social strata. The use of cocaine with levamisole, a frequently added antiparasitic diluent, favors the manifestations of vasculitic lesions, especially in the skin. Read More

    [Granulomatous reaction pattern of the skin : Interstitial granulomatous dermatitis - lymphoma - vasculitis].
    Hautarzt 2017 Jul;68(7):553-559
    Konsultations- und Referenzzentrum für Vaskulitis-Diagnostik, MVZ am Marienkrankenhaus gGmbH, Hamburg, Deutschland.
    A particular diagnostic situation in the classification of a granulomatous dermatitis results when no circumscribed granulomas but instead a diffuse interstitial histiocytic inflammatory infiltrate, a granulomatous vasculitis or a neoplastic lymphocytic infiltrate is found. Interstitial granulomatous dermatitis was originally described in patients with arthritis. Later, it was recognized that there are also associations with other usually immunological diseases. Read More

    Eosinophilic myocarditis presenting as acute coronary syndrome.
    Turk Kardiyol Dern Ars 2017 Jun;45(4):358-361
    Department of Cardiology, Ege University Faculty of Medicine, İzmir, Turkey.
    Eosinophilic myocarditis (EM) is a rare condition that may result from several heterogeneous eosinophilic diseases, including parasite infection, hypersensitivity reaction, vasculitis, and hypereosinophilic syndrome. Regardless of etiology, the disease may present with various cardiac conditions, such as acute coronary syndrome, heart failure, or arrhythmia. Irreversible endomyocardial fibrosis, which causes restrictive cardiomyopathy, occurs in the late phase of the disease. Read More

    Levamisole-Induced Leukocytoclastic Vasculitis with Negative Serology in a Cocaine User.
    Am J Case Rep 2017 Jun 8;18:641-643. Epub 2017 Jun 8.
    Department of Medicine, NYC Health + Hospital/Harlem, Columbia University, New York, NY, USA.
    BACKGROUND Levamisole is a common adulterant of cocaine. It can cause agranulocytosis and cutaneous vasculitis that can possibly lead to cutaneous necrosis. In all reported cases of levamisole-induced vasculitis, it has been described as a clinical syndrome characterized by a constellation of typical clinical features and a positive serum serology for ANCA levels, especially very high-titer p-ANCA levels, in the background of cocaine abuse. Read More

    Cefazolin as a cause of leukocytoclastic vasculitis.
    Clin Case Rep 2017 Jun 12;5(6):1051-1053. Epub 2017 May 12.
    Department of PathologyAbington Memorial Hospital/Abington Jefferson Health1200 Old York RoadAbington19001PA.
    Leukocytoclastic vasculitis (LCV) is a cutaneous small vessel vasculitis characterized by cutaneous manifestations in the form of palpable purpura, and rarely bullae, vesicles, and ulcerations. Although rare, cephalosporins such as cefazolin, should be recognized to have a potential to trigger LCV. Read More

    A Young Boy with L-asparaginase-Induced Seizure.
    Mymensingh Med J 2017 Apr;26(2):459-461
    Dr Md Abdul Aziz, Associate Professor, Department of Haematology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh; E-mail:
    L-Asparaginase is a critical component in the treatment of acute lymphoblastic leukemia in children. It is known to cause coagulation abnormalities, thrombosis and hemorrhage in the central nervous system in addition to vasculitis and hypersensitivity reactions. This syndrome generally occurs after a few weeks of therapy and may occur after L-asparaginase therapy is completed. Read More

    [Evidence of compression therapy].
    Hautarzt 2017 Aug;68(8):625-631
    Klinik- und Poliklinik für Haut- und Geschlechtskrankheiten, Universitätsmedizin Greifswald, F.-Sauerbruchstr., 17475, Greifswald, Deutschland.
    Background: Medical compression therapy is widely used to treat phlebologic diseases. Compression bandages as well as compression stockings are used. Compression has been identified to be an effective conservative therapy for the healing of venous ulcers and other indications. Read More

    [Cutaneous leukocytoclastic vasculitis: about 85 cases].
    Pan Afr Med J 2017 14;26:138. Epub 2017 Mar 14.
    Université du Centre, Tunisie.
    Clinical manifestation, etiology and outcome of leukocytoclastic vasculitis are little studied. The aim of our study was to examine epidemiological, clinical etiological, and evolutionary characteristics of this entity. We conducted a cross-sectional data collection from medical records of 85 patients with leukocytoclastic vasculitis in the Department of Dermatology at the Farhat Hached University Hospital, Sousse between January 2000 and December 2013. Read More

    Demographic characteristics, aetiology, and assessment of treatment options in leukocytoclastic vasculitis.
    Postepy Dermatol Alergol 2017 Apr 13;34(2):104-109. Epub 2017 Apr 13.
    Department of Dermatovenereology, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey.
    Introduction: Vasculitides are a heterogeneous group of diseases characterized by inflammation of the blood vessel walls. Etiological factors include infections, drugs, connective tissue diseases, and malignancies.

    Aim: To examine the demographic characteristics, etiological factors, and treatment options in 75 patients with leukocytoclastic vasculitis. Read More

    Levetiracetam-induced leukocytoclastic vasculitis.
    Indian J Pharmacol 2017 Jan-Feb;49(1):124-126
    Treatwell Skin Centre, Jammu, Jammu and Kashmir, India.
    Drug-induced leukocytoclastic vasculitis is a small-vessel vasculitis that most commonly manifests with palpable purpuric lesions on gravity-dependent areas. Vasculitis occurs within weeks after initial administration of medication and demonstrates clearance upon withdrawal of medication. Levetiracetam, a pyrrolidone derivative, is used as an adjunctive therapy in patients with refractory focal epilepsy, myoclonic epilepsy, and primary generalized tonic-clonic seizures. Read More

    Vasculopathic and vasculitic dermatoses.
    Semin Diagn Pathol 2017 May 7;34(3):285-300. Epub 2017 Apr 7.
    Department of Radiation Oncology, The Ohio State University Wexner Medical Center, United States.
    The inflammatory and non-inflammatory disorders affecting the blood vessels are an important cause of death among patients. Additionally, some of the findings could be very subtle, while the consequences of misdiagnosis tragic. There is a limited number of factors by which the cutaneous blood vessels can be affected and the most common examples in the clinical practice will be discussed here: non-inflammatory purpuras; vascular-occlusive disorders; urticarias; vasculitides; and neutrophilic dermatoses. Read More

    Incidence of autoimmune diseases in patients with scabies: a nationwide population-based study in Taiwan.
    Rheumatol Int 2017 Jul 18;37(7):1125-1134. Epub 2017 Apr 18.
    Graduate Institute of Life Sciences, National Defense Medical Center, No. 161, Sec. 6, Minquan E. Road, Neihu District, Taipei, 114, Taiwan.
    Scabies is a commonly occurring infectious immune-mediated inflammatory skin disease. Immune-mediated inflammatory processes are also observed in autoimmune diseases. There have been very few previous studies; however, that have investigated the possible association between scabies and autoimmune diseases. Read More

    Imatinib mesylate-induced lichenoid drug eruption.
    Cutis 2017 Mar;99(3):189-192
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, USA.
    Imatinib mesylate (imatinib) is a tyrosine kinase inhibitor initially approved by the US Food and Drug Administration in 2001 for chronic myeloid leukemia (CML). Since then, the number of indicated uses for imatinib has substantially increased. It is increasingly important that dermatologists recognize adverse cutaneous manifestations of imatinib and are aware of their management and outcomes to avoid unnecessarily discontinuing a potentially lifesaving medication. Read More

    Cutaneous Manifestations of Diabetes Mellitus: A Review.
    Am J Clin Dermatol 2017 Aug;18(4):541-553
    Department of Dermatology, University Hospital Jena, Erfurter Straße 35, 07740, Jena, Germany.
    Diabetes mellitus is a widespread endocrine disease with severe impact on health systems worldwide. Increased serum glucose causes damage to a wide range of cell types, including endothelial cells, neurons, and renal cells, but also keratinocytes and fibroblasts. Skin disorders can be found in about one third of all people with diabetes and frequently occur before the diagnosis, thus playing an important role in the initial recognition of underlying disease. Read More

    Clinical study on single-organ cutaneous small vessels vasculitis (SoCSVV).
    Medicine (Baltimore) 2017 Mar;96(12):e6376
    aDepartment of Dermatology b2nd Department of Medicine, Jagiellonian University Medical College, Cracow, Poland.
    Leukocytoclastic vasculitis (LCV) is a heterogenous group of disorders that may manifest as a mild disease isolated to the skin or be a part of life-threatening systemic vasculitis. According to the 2012 Chapel Hill Consensus Conference nomenclature, patients presenting symptoms of LCV confined only to the skin should be defined as suffering from a single-organ cutaneous small vessel vasculitis (SoCSVV). SoCSVV is a benign disease with a good clinical outcome but with a significant risk of relapse and skin ulcer formation. Read More

    Scabietic vasculitis: Report of 2 cases.
    Ann Dermatol Venereol 2017 May 18;144(5):349-355. Epub 2017 Mar 18.
    Service de dermatologie, hôpital Nord, chemin des Bourrely, 13015 Marseille, France.
    Background: The infectious causes of cutaneous vasculitis are well known and include streptococcal infections among others. Cases resulting from parasitic infection are less frequent. Scabies, which is currently on the increase, has only been reported in a few isolated cases. Read More

    Interferon-gamma-induced local leukocytoclastic vasculitis at the subcutaneous injection site.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):76-78
    The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University - Guangzhou, China.
    Cutaneous reactions associated with interferons (IFNs) treatment are either localized or generalized. The most common presentation of localized reactions at IFNs injection site is usually an erythematous patch or plaque. Local leukocytoclastic vasculitis presenting with cutaneous necrosis is extremely rare. Read More

    Histopathology of bilateral lower extremity inflammatory lymphedema in military basic trainees: A leukocytoclastic vasculitis of the deep vascular plexus.
    J Cutan Pathol 2017 May 8;44(5):500-503. Epub 2017 Mar 8.
    Colorado Springs Health Partners PC, Department of Dermatology and Dermatopathology, Colorado Springs, Colorado.
    Bilateral lower extremity inflammatory lymphedema (BLEIL) is a recently described condition that presents with exquisite tenderness, erythema and edema of the lower leg, ankle and dorsal foot resembling an acute cellulitis. It was first reported in healthy, young adult military basic trainees with a normal body mass index during the first 72 hours of arrival to basic training. It occurs while standing at attention for many hours, and shows rapid resolution with elevation and rest. Read More

    Leukocytoclastic vasculitis associated with endocarditis in a patient with transposition of the great arteries and mechanical valve replacement.
    Cardiovasc Pathol 2017 Mar - Apr;27:68-70. Epub 2017 Jan 24.
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
    Immunological vascular phenomena can be the initial manifestation of bacterial infection and endocarditis. Here, we report a rare case of leukocytoclastic vasculitis without immune complexes or cryoglobulinemia in a patient with infective endocarditis, congenital heart disease, and a prior mechanical valve replacement. The patient completely recovered following antibiotic therapy, and skin lesions disappeared without immune suppression, which suggested infection-mediated vasculitis. Read More

    Safety of quadrivalent live attenuated influenza vaccine in subjects aged 2-49years.
    Vaccine 2017 Mar 2;35(9):1254-1258. Epub 2017 Feb 2.
    AstraZeneca, One MedImmune Way, Gaithersburg, MD 20878, United States.
    Background: Quadrivalent live attenuated influenza vaccine (Q/LAIV) was licensed in 2012 and replaced trivalent live attenuated influenza vaccine in the United States during the 2013-2014 influenza season. This study assessed the safety of Q/LAIV in children and adults aged 2-49years.

    Methods: This was a prospective observational cohort study using data collected from Kaiser Permanente Northern California. Read More

    Annular lesions of cutaneous sarcoidosis with granulomatous vasculitis.
    J Cutan Pathol 2017 May 2;44(5):494-496. Epub 2017 Mar 2.
    Department of Dermatology, Kansai Medical University, Osaka, Japan.
    Sarcoidosis is known to be involved in diseases with vasculitis as sarcoid vasculitis. However, vasculitis in cutaneous sarcoidal lesions is extremely rare. Here we describe a case of sarcoidosis with multiple annular skin lesions with granulomatous vasculitis. Read More

    Vancomycin-Associated Hemorrhagic Occlusive Retinal Vasculitis: Clinical Characteristics of 36 Eyes.
    Ophthalmology 2017 May 19;124(5):583-595. Epub 2017 Jan 19.
    Retina Consultants of Houston, Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas.
    Purpose: To expand understanding of presentation, diagnosis, and outcomes of hemorrhagic occlusive retinal vasculitis (HORV).

    Design: Retrospective case series.

    Participants: Thirty-six eyes of 23 patients. Read More

    Leukocytoclastic Vasculitis Secondary to Pyridostigmine (Mestinon): Report of a Possible First Case.
    Perm J 2017 18;21. Epub 2016 Nov 18.
    Consultant in Medicine at The Dunedin Hospital; an Honorary Clinical Senior Lecturer at the University of Otago School of Medicine in Dunedin, New Zealand; Clinical Assistant Professor of Medicine at Stanford University School of Medicine; and a Hospitalist at the Santa Clara Medical Center in CA.
    Introduction: Pyridostigmine is an acetylcholinesterase inhibitor commonly used in the treatment of myasthenia gravis. We describe a patient who developed a rash after recently being started on pyridostigmine and give a general review of leukocytoclastic vasculitis.

    Case Presentation: A 91-year-old man was diagnosed with ocular myasthenia gravis. Read More

    ANCA-Negative Churg-Strauss Syndrome Presenting as Acute Multiple Cerebral Infarcts: A Case Report.
    J Stroke Cerebrovasc Dis 2017 Mar 5;26(3):e47-e49. Epub 2017 Jan 5.
    Stroke Unit, Mediterraneo Hospital, Athens, Greece.
    Eosinophilic granulomatosis with polyangiitis (EGPA, previously named Churg-Strauss syndrome) is a form of necrotizing vasculitis occurring in patients with asthma and eosinophilia. Ischemic stroke is a relatively rare complication of the disease. We report a case of a 63-year-old woman with multiple embolic infarcts, hypereosinophilia (for >7 years), and skin rash. Read More

    Dabigatran-related leukocytoclastic vasculitis.
    BMJ Case Rep 2017 Jan 4;2017. Epub 2017 Jan 4.
    Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
    Dabigatran is a non-vitamin K antagonist oral anticoagulant that has been approved for atrial fibrillation and prevention of venous thromboembolism. Its use has been increasing in the USA since serum drug levels do not need monitoring. To date, no significant skin side effects have been reported other than 4 cases of non-specific skin lesion and 2 cases of leukocytoclastic vasculitis (LCV), which is a small vessel inflammatory disease that presents as palpable purpura in lower extremities. Read More

    Suppressive influence of seasonal influenza epidemic on Kawasaki disease onset.
    Nihon Rinsho Meneki Gakkai Kaishi 2016 ;39(6):528-537
    Dermatology & Epidemiology Research Institute (DERI).
      Kawasaki disease (KD) is an acute systemic vasculitis presenting as an infantile febrile disease. In Japan, the widespread cedar plantation commenced in 1945 has been correlated with the increased incidences of both KD and allergic rhinitis (pollinosis) since the early 1960s. We previously showed that KD was a pollen-induced, delayed-type hypersensitivity that displays biphasic peaks in both summer and winter. Read More

    Aseptic Lymphocytic-Dominated Vasculitis-Associated Lesions Scores Do Not Correlate With Metal Ion Levels or Unreadable Synovial Fluid White Blood Cell Counts.
    J Arthroplasty 2017 Apr 22;32(4):1340-1343. Epub 2016 Nov 22.
    Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois.
    Background: Failed metal-on-metal (MoM) bearings are being increasingly encountered with little information to guide evaluation for aseptic lymphocytic-dominated vasculitis-associated lesions (ALVAL). It is often assumed that elevated metal ion levels correlate with the occurrence of ALVAL. Our purpose was to determine the utility of the erythrocyte sedimentation rate, C-reactive protein, synovial white blood cell count, differential (%PMN), and serum metal ion levels in diagnosing ALVAL. Read More

    Acrally distributed dermatoses: Vascular dermatoses (purpura and vasculitis).
    Clin Dermatol 2017 Jan - Feb;35(1):68-80. Epub 2016 Sep 10.
    Department of Dermatology and Venereology, Tokuda Hospital Sofia, Sofia, Bulgaria.
    Purpuric lesions appear in acral distribution in a variety of conditions and often provide clues to the clinical diagnosis. Purpuric means "hemorrhagic"-that is, the lesions do not blanch from pressure. This review focuses on dermatoses that produce hemorrhagic lesions in acral distribution from the large groups of the vasculitic diseases and their mimics. Read More

    Chronic Localized Fibrosing Leukocytoclastic Vasculitis Associated With Lymphedema, Intralymphatic and Intravascular Lymphocytosis, and Chronic Myelogenous Leukemia: A Case Report of Unilateral Erythema Elevatum Diutinum.
    Am J Dermatopathol 2017 Jun;39(6):479-484
    *Department of Pathology, Albany Medical College, Albany, NY; and †Departamento de Dermatología, Area de Dermatopatología, Hospital Luis Vernaza, Guayaquil, Ecuador.
    One of the pathogenic causes of cutaneous inflammatory pseudotumors is chronic localized fibrosing leukocytoclastic vasculitis (CLFLCV), a vasculitic reaction pattern seen in granuloma faciale (GF), a localized vasculitis, and erythema elevatum diutinum (EED), a generalized vasculitis. Patients with myelodysplastic syndromes (MDSs) are at risk for a diverse spectrum of cutaneous neutrophilic dermatoses such as EED. Herein, we report a 74-year-old man who presented with a large ulcerative, fungating tumor affecting the right flexor ankle caused by CLFLCV. Read More

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