18,221 results match your criteria Hypersensitivity Reactions Immediate


Usefulness of basophil activation test in the diagnosis of amiodarone hypersensitivity.

J Investig Allergol Clin Immunol 2019 Apr 24. Epub 2019 Apr 24.

Department of Allergy, Hospital La Paz Institute for Health Research (IdiPaz), Madrid. Spain.

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http://dx.doi.org/10.18176/jiaci.0404DOI Listing

Association of HLA genotypes with Beta-lactam antibiotic hypersensitivity in children.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand 10400.

Background: Beta-lactam (BL) antibiotics hypersensitivity is common in children. Clinical manifestation of BL hypersensitivity varies from mild to severe cutaneous adverse drug reactions (SCARs).

Objective: To determine the association of HLA genotype and BL hypersensitivity and the prevalence of true drug allergy in patients with history of BL hypersensitivity. Read More

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http://dx.doi.org/10.12932/AP-271118-0449DOI Listing

Radiocontrast media hypersensitivity: skin testing differentiates allergy from non-allergic reactions and identifies a safe alternative as proven by intravenous provocation.

J Allergy Clin Immunol Pract 2019 Apr 10. Epub 2019 Apr 10.

Department of Dermatology and Allergy, University Hospital Würzburg, Germany.

Background: Hypersensitivity reactions occurring within minutes after intravascular injection of iodinated radiocontrast media (RCM) are common and have been previously considered to be non-allergic. However, in the last decades, evidence is increasing that also genuine RCM allergy may present as either full-blown anaphylaxis or delayed exanthematous skin reaction.

Objectives: We aimed to assess whether allergy diagnostics including skin and provocation testing can differentiate between non-allergic and allergic RCM hypersensitivity by identifying the causative RCM as well as tolerated alternative RCM. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.04.005DOI Listing
April 2019
1 Read

Mesalamine-induced Myocarditis in a Young Athlete: Can He Run Again?

Cureus 2019 Jan 29;11(1):e3978. Epub 2019 Jan 29.

Cardiology, State University of New York at Buffalo, Buffalo, USA.

Mesalamine is often used in the treatment of inflammatory bowel disease (IBD). Mesalamine-induced cardiotoxicity has been reported in the literature and is a rare entity. The mechanism of cardiotoxicity remains unclear, however, it is believed to be due to a humoral-mediated hypersensitivity reaction. Read More

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http://dx.doi.org/10.7759/cureus.3978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440563PMC
January 2019
3 Reads

An EAACI position paper on the investigation of perioperative immediate hypersensitivity reactions.

Allergy 2019 Apr 9. Epub 2019 Apr 9.

Allergy Unit, Department of Dermatology, University Hospital, University of Basel, Basel, Switzerland.

Perioperative immediate hypersensitivity reactions are rare. Subsequent allergy investigation is complicated by multiple simultaneous drug exposures, the use of drugs with potent effects and the many differential diagnoses to hypersensitivity in the perioperative setting. The approach to the investigation of these complex reactions is not standardized and it is becoming increasingly apparent that collaboration between experts in the field of allergy/immunology/dermatology and anaesthesiology is needed to provide the best possible care for these patients. Read More

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http://dx.doi.org/10.1111/all.13820DOI Listing
April 2019
1 Read

Hypersensitivity reactions to antiepileptic drugs in children.

Pediatr Allergy Immunol 2019 Apr 5. Epub 2019 Apr 5.

University of Belgrade-Faculty of Medicine, Belgrade, Serbia.

Background: Antiepileptic drugs (AEDs) can cause hypersensitivity reactions in children. These reactions are mainly cutaneous, self-limiting and benign but life-threatening severe cutaneous adverse reactions can occur. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions, if a drug is taken at the same time. Read More

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http://dx.doi.org/10.1111/pai.13055DOI Listing
April 2019
2 Reads

The alpha-Gal syndrome: new insights into the tick-host conflict and cooperation.

Parasit Vectors 2019 Apr 3;12(1):154. Epub 2019 Apr 3.

UMR BIPAR, INRA, ANSES, Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, Maisons-Alfort, 94700, France.

This primer focuses on a recently diagnosed tick-borne allergic disease known as the alpha-Gal syndrome (AGS). Tick bites induce in humans high levels of IgE antibodies against the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) present on tick salivary glycoproteins and tissues of non-catarrhine mammals, leading to the AGS in some individuals. This immune response evolved as a conflict and cooperation between ticks and human hosts including their gut microbiota. Read More

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http://dx.doi.org/10.1186/s13071-019-3413-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448316PMC
April 2019
1 Read

Immediate and delayed hypersensitivity after intra-arterial injection of iodinated contrast media: a prospective study in patients with coronary angiography.

Eur Radiol 2019 Apr 1. Epub 2019 Apr 1.

Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, South Korea.

Objectives: While hypersensitivity reactions (HSR) to intravenously administered iodinated contrast media (ICM) have been well studied, not much is known about HSR to intra-arterially administered ICM.

Methods: A prospective observational study was performed to evaluate coronary angiography (CAG)-induced ICM hypersensitivity in patients who underwent CAG using ICM including ioversol, a low-osmolar non-ionic monomer, and iodixanol, an iso-osmolar non-ionic dimer. The HSR were investigated through in-patient monitoring after CAG and telephone interview after discharge. Read More

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http://dx.doi.org/10.1007/s00330-019-06138-3DOI Listing
April 2019
4 Reads

Flucloxacillin hypersensitivity: patient outcomes in a multi-center retrospective study.

J Allergy Clin Immunol Pract 2019 Mar 25. Epub 2019 Mar 25.

Department of Allergy, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, CB2 0QQ, UK.

Background: Flucloxacillin is a narrow spectrum, beta-lactamase resistant penicillin. Type I (IgE mediated) and type IV (T-cell mediated) reactions are less frequently reported than with other penicillins.

Objective: To undertake a detailed clinical characterization of a cohort of patients referred with suspected flucloxacillin hypersensitivity. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.03.018DOI Listing
March 2019
2 Reads

Molecular mechanisms and pathophysiology of perioperative hypersensitivity and anaphylaxis: a narrative review.

Br J Anaesth 2019 Mar 7. Epub 2019 Mar 7.

Anaesthetic Allergy Referral Centre of Western Australia, Department of Anaesthesia, Sir Charles Gairdner Hospital, Perth, Australia; Department of Pharmacology, University of Western Australia, Perth, Australia.

Perioperative hypersensitivity reactions (POH) constitute a clinical and diagnostic challenge, a consequence of heterogeneous clinical presentations, and multiple underlying pathomechanisms. POH do not necessarily involve an allergen-specific immune response with cross-linking of specific immunoglobulin E (sIgE) antibodies on mast cells and basophils. POH can also result from alternative specific and non-specific effector cell activation/degranulation such as complement-derived anaphylatoxins and off-target occupancy of mast cell, basophil, or both surface receptors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00070912193007
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http://dx.doi.org/10.1016/j.bja.2019.01.031DOI Listing
March 2019
5 Reads

Anaesthetic management of patients with pre-existing allergic conditions: a narrative review.

Br J Anaesth 2019 Mar 12. Epub 2019 Mar 12.

Department of Anaesthesia and Peri-operative Medicine, Auckland City Hospital, Auckland, New Zealand.

This narrative review seeks to distinguish the clinical patterns of pre-existing allergic conditions from other confounding non-allergic clinical entities, and to identify the potential related risks and facilitate their perioperative management. Follow-up investigation should be performed after a perioperative immediate hypersensitivity to establish a diagnosis and provide advice for subsequent anaesthetics, the main risk factor for perioperative immunoglobulin E (IgE)-mediated anaphylaxis being a previous uninvestigated perioperative immediate hypersensitivity reaction. The concept of cross-reactivity between drugs used in the perioperative setting and food is often quoted, but usually not supported by evidence. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00070912193006
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http://dx.doi.org/10.1016/j.bja.2019.01.020DOI Listing
March 2019
7 Reads

In vitro diagnostic tests for perioperative hypersensitivity, a narrative review: potential, limitations, and perspectives.

Br J Anaesth 2019 Feb 11. Epub 2019 Feb 11.

Department of Immunology, Allergology, and Rheumatology, University Antwerp, Antwerp University Hospital, Antwerp, Belgium.

Correct diagnostic management of perioperative hypersensitivity aims to identify the underlying mechanism(s), responsible culprit(s), and safe alternative drugs or techniques. Although drug provocation tests are considered the gold standard, diagnosis of perioperative hypersensitivity mainly relies on skin testing. Use of in vitro tests, such as quantification of specific immunoglobulin E antibodies, serum tryptase, and plasma histamine, as well as basophil activation tests is becoming widespread. Read More

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http://dx.doi.org/10.1016/j.bja.2019.01.002DOI Listing
February 2019
1 Read

Short and extended provocation tests have similar negative predictive value in non-immediate hypersensitivity to beta-lactams in children.

Allergol Immunopathol (Madr) 2019 Mar 22. Epub 2019 Mar 22.

Serviço de Imunoalergologia, Centro Hospitalar do Porto, Porto, Portugal. Electronic address:

Introduction And Objectives: Drug provocation tests (DPTs) are the gold-standard method to diagnose non-immediate hypersensitivity reactions (NIHSR) to beta-lactam antibiotics (BL) in children. Our aim was to compare the negative predictive value (NPV) of one-day (short) DPT versus 3-7 days (extended) DPT for the diagnosis of NIHSR to BL in paediatric age. A secondary aim was to compare confidence on drug re-exposure after short and extended negative DPTs. Read More

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http://dx.doi.org/10.1016/j.aller.2019.01.004DOI Listing
March 2019
2 Reads

Clinical characteristics of eperisone-induced immediate-type hypersensitivity.

Asian Pac J Allergy Immunol 2019 Mar 24. Epub 2019 Mar 24.

Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Eperisone is a commonly prescribed oral muscle relaxant, but few studies have been conducted of eperisone-induced hypersensitivity reactions.

Objective: The purpose of this study was to investigate the clinical manifestations of eperisone-induced immediate-type hypersensitivity, and to evaluate the role of an intradermal test (IDT) in eperisone-induced anaphylaxis.

Methods: This study was based on a retrospective review of medical records from 23 patients diagnosed as eperisone-induced immediate-type hypersensitivity with certain or probable causality. Read More

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http://dx.doi.org/10.12932/AP-211018-0420DOI Listing
March 2019
1 Read

Serum Baseline Tryptase Level as a Marker for the Severity of Anaphylaxis.

Int Arch Allergy Immunol 2019 Mar 20:1-8. Epub 2019 Mar 20.

Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil,

Background: Anaphylaxis is a severe and potentially fatal allergic disease or hypersensitivity reaction with variable clinical presentation. Biomarkers in anaphylaxis could be useful to improve diagnosis, to allow endotyping of patients, and to predict risk.

Objective: To investigate the role of serum basal tryptase (sBT) levels in the management of patients with anaphylaxis. Read More

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http://dx.doi.org/10.1159/000497235DOI Listing
March 2019
2 Reads

Comparison of two desensitizing agents for decreasing dentin hypersensitivity following periodontal surgeries: a randomized clinical trial.

Quintessence Int 2019 ;50(4):320-329

Objective: Dentin hypersensitivity (DH) is a common problem with multifactorial etiology. It is characterized by a short, sharp pain due to exposed dentin usually at the cervical margin. This randomized clinical trial aimed to evaluate the efficacy of two desensitizing agents for reduction of dentin hypersensitivity (DH) following periodontal surgeries. Read More

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https://qi.quintessenz.de/index.php?doc=abstract&abstrac
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http://dx.doi.org/10.3290/j.qi.a42096DOI Listing
January 2019
6 Reads
0.728 Impact Factor

Differences in Adverse Reactions Among Iodinated Contrast Media: Analysis of the KAERS Database.

J Allergy Clin Immunol Pract 2019 Mar 12. Epub 2019 Mar 12.

Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Pharmacovigilance Center, Asan Medical Center, Seoul, Korea. Electronic address:

Background: The various adverse drug reactions (ADRs) arise from different types of iodinated contrast media (ICM).

Objective: Thus, we investigated the occurrence rate and types of ADRs according to the total usage cases of the 7 most common ICM.

Methods: We retrospectively reviewed 74,242 causal ADRs caused by ICM from the Korea Adverse Event Reporting System database between January 2014 and December 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132198193025
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http://dx.doi.org/10.1016/j.jaip.2019.02.035DOI Listing
March 2019
9 Reads

BAT in the Diagnosis of Drug Allergy: a Novel Tool in Clinical Daily Practice?

Curr Allergy Asthma Rep 2019 Mar 11;19(4):20. Epub 2019 Mar 11.

Clinical Immunology and Allergy Division, University of São Paulo, R. Prof. Artur Ramos 178 ap.211A, Jd. América, São Paulo, SP, CEP: 01454-904, Brazil.

Purpose Of Review: The aim of this study is to critically review the relevant literature published on basophil activation test, presenting the current knowledge and future perspectives.

Recent Findings: Basophil activation test (BAT) results varied accordingly to the class of the drug studied, and have promising results in immediate hypersensitivity reactions to pyrazolone (selective reactors), neuromuscular blockers, beta-lactams, and platinum compounds, all examples of classical IgE-mediated hypersensitivity drug reactions. Currently, BAT is applied in research settings, but based in the results of our review, the test can be considered as a diagnostic tool for daily practice for selected patients and selected drugs, when the test is available, particularly for patients who experienced severe reactions and when diagnosis cannot be stablished by serum-specific IgE and skin testing, in order to avoid unnecessary drug provocations tests. Read More

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http://dx.doi.org/10.1007/s11882-019-0852-8DOI Listing
March 2019
1 Read

Allergic contact dermatitis to chlorhexidine in pediatric patients.

Pediatr Dermatol 2019 Mar 5. Epub 2019 Mar 5.

Department of Dermatology, Hospital General Universitario de Valencia, Valencia, Spain.

Chlorhexidine is one of the most widely used antiseptics in our environment. Allergic contact dermatitis to chlorhexidine is common in adults, but is quite rare in the pediatric population. Its diagnosis is important because it can mimic other dermatoses common during childhood, and it can also lead to acute immediate hypersensitivity reactions following successive exposures. Read More

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http://dx.doi.org/10.1111/pde.13808DOI Listing
March 2019
5 Reads

Allergic reactions to cow's milk proteins in medications in childhood.

Acta Biomed 2019 Jan 29;90(3-S):91-93. Epub 2019 Jan 29.

Clinica Pediatrica, Dipartimento di Medicina e Chirurgia, Azienda Ospedaliero-Universitaria, Università di Parma, Italy.

Cow's milk is a frequent trigger of allergic reactions in childhood. Cow's milk proteins can be present in pharmaceutical excipients.

Methods: We have analyzed paediatric literature on allergic reactions to cow's milk proteins in medication, focusing on the different routes of administration (inhaled, parental and oral). Read More

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http://dx.doi.org/10.23750/abm.v90i3-S.8169DOI Listing
January 2019
6 Reads

Immediate hypersensitivity to polyethylene glycols in unrelated products: when standardization in the nomenclature of the components of drugs, cosmetics, and food becomes necessary.

Allergy Asthma Clin Immunol 2019 19;15. Epub 2019 Feb 19.

2Servicio de Análisis Clínicos e Inmunología, Hospital General Universitario de Alicante, Alicante, Spain.

Background: Polyethylene glycols (PEGs) and their derivatives are non-ionic polymers of ethylene oxide commercially available with numerous synonyms, such as macrogol, oxyethylene polymer, and laureth-9. Although these polymers are usually safe, mild to life-threatening immediate-type hypersensitivity reactions have been reported. Nevertheless, awareness about their allergic potential is minimal due to the non-standardization of their nomenclature. Read More

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http://dx.doi.org/10.1186/s13223-019-0327-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381633PMC
February 2019
1 Read

Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy: The PEPITES Randomized Clinical Trial.

JAMA 2019 Feb 22. Epub 2019 Feb 22.

Massachusetts General Hospital, Boston.

Importance: There are currently no approved treatments for peanut allergy.

Objective: To assess the efficacy and adverse events of epicutaneous immunotherapy with a peanut patch among peanut-allergic children.

Design, Setting, And Participants: Phase 3, randomized, double-blind, placebo-controlled trial conducted at 31 sites in 5 countries between January 8, 2016, and August 18, 2017. Read More

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2019.1113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439674PMC
February 2019
30 Reads

Current Strategies to Inhibit High Affinity FcεRI-Mediated Signaling for the Treatment of Allergic Disease.

Authors:
Gregorio Gomez

Front Immunol 2019 7;10:175. Epub 2019 Feb 7.

Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, United States.

Allergies and asthma are a major cause of chronic disease whose prevalence has been on the rise. Allergic disease including seasonal rhinitis, atopic dermatitis, urticaria, anaphylaxis, and asthma, are associated with activation of tissue-resident mast cells and circulating basophils. Although these cells can be activated in different ways, allergic reactions are normally associated with the crosslinking of the high affinity Fc receptor for Immunoglobulin E, FcεRI, with multivalent antigen. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374298PMC
February 2019
2 Reads

Low Cross-Reactivity Between Cisplatin and Other Platinum Salts.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Dermatology Department, Dijon University Hospital, Dijon, France.

Background: Hypersensitivity reactions to platinum salts (PS) (cisplatin [CI], carboplatin [CA], and oxaliplatin [OX]) can be severe and their incidence is increasing due to their widespread use in cancer treatment.

Objective: To determine the rate of cross-reactivity between PS and whether CI can be administered without prior allergy testing in patients with a history of CA or OX hypersensitivity.

Methods: From September 2002 to April 2016, patients with suspected immediate PS hypersensitivity were tested and cross-reactivity between the 3 PS was evaluated. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.057DOI Listing
February 2019
3 Reads

Health care worker sensitivity to chlorhexidine-based hand hygiene solutions: A cross-sectional survey.

Am J Infect Control 2019 Feb 11. Epub 2019 Feb 11.

School of Nursing and Midwifery, Deakin University, Geelong, Victoria, Australia; Centre for Quality and Patient Safety Research-Monash Health Partnership, School of Nursing and Midwifery, Deakin University, Burwood, Victoria, Australia. Electronic address:

Background: Health service hand hygiene programs have seen widespread use of chlorhexidine solutions. Reports of both immediate and delayed hypersensitivity to chlorhexidine are increasing among health care workers. This study examined the prevalence of self-reported symptoms of sensitivity to chlorhexidine solutions among health care workers. Read More

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http://dx.doi.org/10.1016/j.ajic.2019.01.006DOI Listing
February 2019
3 Reads

Immediate hypersensitivity reaction to human serum albumin in a child undergoing plasmapheresis.

Transfusion 2019 Feb 13. Epub 2019 Feb 13.

Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Background: Human serum albumin (HSA) is a commonly used colloid for volume expansion and albumin replacement and during plasmapheresis. Colloids are an uncommon cause of anaphylaxis, and cases of hypersensitivity reactions to HSA are extremely rare.

Case Report: A 10-year-old boy with chronic inflammatory demyelinating polyneuropathy was treated with plasmapheresis, with albumin as the replacement fluid. Read More

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http://dx.doi.org/10.1111/trf.15194DOI Listing
February 2019
1 Read

The role of antimicrobial treatment during pregnancy on the neonatal gut microbiome and the development of atopy, asthma, allergy and obesity in childhood.

Expert Opin Drug Saf 2019 Mar 22;18(3):173-185. Epub 2019 Feb 22.

c Division of Surgery , University College London, Northwick Park Institute of Medical Research Campus , London , UK.

Introduction: The use of antibiotics prenatally, during pregnancy, or neonatally may have adverse effects on the neonatal gut microbiome, and adversely affect the development of the infant immune system, leading to childhood atopy, asthma, allergy and obesity. Areas covered: Vaginal eubiosis and dysbiosis from molecular-based, cultivation-independent techniques, and how this affects the neonatal gut microbiome and early development of the immune system, the association between maternal antibiotics and the beneficial role of vitamin D in the development of atopy, asthma, allergy and obesity, efforts to reduce the use of antibiotics in pregnancy and therapeutic interventions such as vaginal 'seeding', probiotics, breastfeeding and neonatal dietary supplementation. Expert opinion: Currently available research gives insufficient attention to confounding variables. Read More

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http://dx.doi.org/10.1080/14740338.2019.1579795DOI Listing
March 2019
5 Reads

Skin tests are important in children with β-lactam hypersensitivity, but may be reduced in number.

Pediatr Allergy Immunol 2019 Feb 7. Epub 2019 Feb 7.

Allergy Unit, Département de Pneumologie et Addictologie, Hôpital Arnaud de Villeneuve, CHU de Montpellier, Univ Montpellier, Montpellier, France.

Background: There is no perfect agreement on how to perform an allergy workup in suspected beta-lactam (BL)-allergic children, since skin test (ST)-induced pain is often a limitation. The aim of the study was to assess the possibility of reducing the number of ST in children when performing a complete allergy workup for BL hypersensitivity reactions.

Methods: A retrospective analysis of all patients referring to the Allergy Unit of the University Hospital of Montpellier (France) with positive responses in immediateand non-immediate-reading ST to a BL over a 16-year period was performed, to determine the positive predictive value (PPV) of ST. Read More

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http://dx.doi.org/10.1111/pai.13041DOI Listing
February 2019
3 Reads

Diagnosis and management of drug-induced anaphylaxis in children: an EAACI position paper.

Pediatr Allergy Immunol 2019 Feb 7. Epub 2019 Feb 7.

Geneva University Hospitals, Department of child and adolescent, Pediatric Allergy Unit, Geneva, Switzerland.

Drug hypersensitivity reactions (DHR) constitute a major and common public health problem, particularly in children. One of the most severe manifestations of DHR is anaphylaxis, which might be associated with a life-threatening risk. During those past decades, anaphylaxis has received particularly a lot of attention and international consensus guidelines have been recently published. Read More

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http://dx.doi.org/10.1111/pai.13034DOI Listing
February 2019
2 Reads

Allergic Reactions Captured by Voluntary Reporting.

J Patient Saf 2019 Jan 31. Epub 2019 Jan 31.

Edward P. Lawrence Center for Quality and Safety, Massachusetts General Hospital and the Massachusetts General Professional Organization.

Background: The epidemiology of hospital adverse reactions (ARs), particularly allergic reactions, or hypersensitivity reactions (HSRs), is poorly defined. To determine priorities for allergy safety in healthcare, we identified and described safety reports of allergic reactions.

Methods: We searched the safety report database of a large academic medical center from April 2006 to March 2016 using 101 complete, truncated, and/or misspelled key words related to allergic symptoms, treatments, and culprits (e. Read More

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http://dx.doi.org/10.1097/PTS.0000000000000568DOI Listing
January 2019
5 Reads

Efficacy of 8% arginine on dentin hypersensitivity: A multicenter clinical trial in 273 patients over 24 weeks.

J Dent 2019 Apr 30;83:1-6. Epub 2019 Jan 30.

Department of Operative Dentistry and Periodontology, School of Dental Medicine, Martin-Luther-University, Magdeburger Strasse 16, 06120, Halle, Germany. Electronic address:

Objectives: To assess the efficacy of 8% arginine containing prophylaxis products over 24 weeks in subjects with dentin hypersensitivity (DH).

Methods: 297 patients with established DH (Schiff score 2, 3) in three European study centers were randomly assigned to either 8% arginine and calcium carbonate in-office prophylaxis paste and the respective toothpaste (test group) or fluoride-free prophylaxis paste and sodium monoflourophosphate toothpaste as a negative control group. Air blast (Schiff Score) and tactile (Visual Analog Scale) sensitivity scores were assessed at baseline (BL_0), after single application of the prophylaxis paste (BL_1) and after 4, 8, and 24 weeks of continuous at-home use of the toothpaste. Read More

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http://dx.doi.org/10.1016/j.jdent.2019.01.002DOI Listing
April 2019
2 Reads

Wilderness Dermatology: Bugs, Plants, and Other Nuisances That May Ruin Your Hike.

R I Med J (2013) 2019 Feb 1;102(1):16-22. Epub 2019 Feb 1.

Brown University Department of Dermatology.

Spending time outdoors can be rewarding. However, exposure to the sun, insect bites, and plant exposures may result in a wide range of dermatologic manifestations. In this article, we describe potential cutaneous manifestations of common wilderness exposures in New England including photodermatoses from prolonged sun exposure, phytodermatoses from plant exposures, and arthropod-bite reactions from common insects (mosquitos, spiders, ticks, hymenoptera, mites and chiggers). Read More

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February 2019
3 Reads

Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate.

Diabetologia 2019 May 31;62(5):811-821. Epub 2019 Jan 31.

Diabetes Research Institute and Cell Transplant Center, University of Miami Miller School of Medicine, 1450 NW 10th Ave, Miami, FL, 33136, USA.

Aims/hypothesis: Patients with autoimmune type 1 diabetes transplanted with pancreatic islets to their liver experience significant improvement in quality of life through better control of blood sugar and enhanced awareness of hypoglycaemia. However, long-term survival and efficacy of the intrahepatic islet transplant are limited owing to liver-specific complications, such as immediate blood-mediated immune reaction, hypoxia, a highly enzymatic and inflammatory environment and locally elevated levels of drugs including immunosuppressive agents, all of which are injurious to islets. This has spurred a search for new islet transplant sites and for innovative ways to achieve long-term graft survival and efficacy without life-long systemic immunosuppression and its complications. Read More

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http://dx.doi.org/10.1007/s00125-019-4814-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451664PMC
May 2019
7 Reads
6.671 Impact Factor

The clinical toxicology of sodium hypochlorite.

Clin Toxicol (Phila) 2019 May 28;57(5):303-311. Epub 2019 Jan 28.

a National Poisons Centre , University of Otago , Dunedin , New Zealand.

Introduction: Sodium hypochlorite is used as a bleaching and disinfecting agent and is commonly found in household bleach.

Objective: The objective is to review critically the epidemiology, mechanisms of toxicity, clinical features, diagnosis, and management of hypochlorite poisoning.

Methods: PubMed was searched from January 1950 to June 2018 using the terms "Hypochlorite", "Sodium Hypochlorite", "Sodium Oxychloride", "Hypochlorous Acid", "Bleach", "Chlorine Bleach", in combination with the keywords "poisoning", "poison", "toxicity", "ingestion", "adverse effects", "overdose", and "intoxication". Read More

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http://dx.doi.org/10.1080/15563650.2018.1543889DOI Listing
May 2019
3 Reads

New IgE immediate hypersensitivity reactions on reintroduction of food restricted for treatment of eosinophilic esophagitis.

Ann Allergy Asthma Immunol 2019 Apr 24;122(4):419-420. Epub 2019 Jan 24.

Department of Gastroenterology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1016/j.anai.2019.01.010DOI Listing
April 2019
3 Reads

Vaccine Allergy? Skin Testing and Challenge at a Tertiary Pediatric Hospital in Melbourne, Australia.

J Allergy Clin Immunol Pract 2019 Jan 23. Epub 2019 Jan 23.

Department of Allergy and Immunology, Royal Children's Hospital, Melbourne, Australia; Population Allergy Research Group and Melbourne Children's Trial Centre, Murdoch Children's Research Institute, Melbourne, Australia; Department of General Medicine, Royal Children's Hospital, Melbourne, Australia; Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia. Electronic address:

Background: The rate of true vaccine allergy is unknown. Children with potential IgE-mediated adverse events following immunization (AEFI) should undergo allergy investigation that may include skin testing or challenge. Previous protocols tend to be highly conservative and often suggest invasive testing for all, a practice not evidence based, technically difficult, and unpleasant in children. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.025DOI Listing
January 2019
16 Reads

Common causes of emergency department visits for anaphylaxis in Korean community hospitals: A cross-sectional study.

Medicine (Baltimore) 2019 Jan;98(4):e14114

Division of Allergy and Clinical Immunology, Kangwon National University School of Medicine, Chuncheon, Korea.

Anaphylaxis can cause death and requires immediate management. For prevention and education programs for anaphylaxis, it is important to be aware of the common triggering factors. We investigated the triggers of anaphylaxis in the emergency departments (EDs) of community hospitals in Korea. Read More

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http://dx.doi.org/10.1097/MD.0000000000014114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358383PMC
January 2019
12 Reads

The incidence of skin lesions in contrast media-induced chemical hypersensitivity.

Exp Ther Med 2019 Feb 5;17(2):1113-1124. Epub 2018 Dec 5.

Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

Contrast agents are used in radiology to increase the sensibility and specificity of radiological techniques. Some of these compounds have side effects that include organ toxicity (with kidney being the most affected organ) and hypersensitivity reactions. We performed multiple PubMed searches from January, 2008 to January, 2018 for studies regarding adverse reactions to compounds used as contrast agents in imagistic techniques. Read More

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http://dx.doi.org/10.3892/etm.2018.7056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327547PMC
February 2019
8 Reads

Incidence and risk factors of low-osmolar iodinated contrast media related immediate hypersensitivity reactions: A longitudinal study based on a real-time monitoring system.

J Investig Allergol Clin Immunol 2019 Jan 24. Epub 2019 Jan 24.

Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.

Background: We investigated the incidence of immediate hypersensitivity reaction (HSR) focusing on the types of low osmolar contrast media (LOCM) and accumulated exposures to LOCM.

Methods: This cohort study included all consecutive patients who underwent LOCM-enhanced computed tomography scan from 2012 through 2014. Five LOCMs (iobitridol, iohexol, iomeprol, iopamidol, and iopromide) were used. Read More

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http://dx.doi.org/10.18176/jiaci.0374DOI Listing
January 2019
3 Reads

Eperisone-Induced Anaphylaxis: Pharmacovigilance Data and Results of Allergy Testing.

Allergy Asthma Immunol Res 2019 Mar;11(2):231-240

Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Eperisone is an oral muscle relaxant used in musculoskeletal disorders causing muscle spasm and pain. For more effective pain control, eperisone is usually prescribed together with nonsteroidal anti-inflammatory drugs (NSAIDs). As such, eperisone may have been overlooked as the cause of anaphylaxis compared with NSAIDs. Read More

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http://dx.doi.org/10.4168/aair.2019.11.2.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340802PMC
March 2019
3 Reads

A Novel Desensitization Protocol for Infliximab hypersensitivity in a 13-Year Old Patient with Pustular Psoriasis.

Curr Drug Saf 2019 Jan 18. Epub 2019 Jan 18.

Department of Pharmacology, Sri Ramachandra Institute of Higher Education and Research, Chennai. India.

Background: Drug hypersensitivity reactions to infliximab have been reported in pediatric patients. At times, these patients may need infliximab administration in spite of hypersensitivity. However, only a few reports of desensitization protocols are available in the literature in pediatric patients. Read More

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http://dx.doi.org/10.2174/1574886314666190119115632DOI Listing
January 2019
12 Reads

Cross-reactivity between halogenated platinum salts in an immediate-type respiratory hypersensitivity model.

Inhal Toxicol 2018 Sep - Oct;30(11-12):472-481. Epub 2019 Jan 18.

a Cardiopulmonary and Immunotoxicology Branch, Environmental Public Health Division, National Health, and Environmental Effects Laboratory (NHEERL) , U.S. Environmental Protection Agency , Research Triangle Park , NC , USA.

Halogenated platinum salts can trigger the development of occupational asthma. Until recently, laboratory research into the development and manifestation of platinum hypersensitivity responses were hindered by the lack of an animal model suitable for assessing the functional consequences of allergic sensitization. We employed a newly developed mouse model to assess the potential allergenicity of ammonium tetrachloroplatinate (ATCP), compare the relative potency of ATCP and another platinum salt, ammonium hexachloroplatinate (AHCP) and assess potential cross-reactivity. Read More

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http://dx.doi.org/10.1080/08958378.2018.1554015DOI Listing
January 2019
3 Reads

Series of 12 cases of wheat-dependent exercise-induced allergy in Aragon, Spain.

Rev Clin Esp 2019 Jan 13. Epub 2019 Jan 13.

Servicio de Alergología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, España.

Background And Objectives: The ω-5 gliadin (ω5G) is considered the main allergen in wheat-dependent exercise-induced anaphylaxis (WDEIA). These patients experience anaphylactic reactions after consuming wheat and performing physical exercise. The aim of our study was to describe the main characteristics of 12 patients with this diagnosis. Read More

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http://dx.doi.org/10.1016/j.rce.2018.11.004DOI Listing
January 2019
4 Reads

Lidocaine as a Rare and Hidden Allergen in the Perioperative Setting: A Case Report.

A A Pract 2019 Jan 4. Epub 2019 Jan 4.

From the Danish Anaesthesia Allergy Centre, Allergy Clinic, Department of Dermatology and Allergology, Herlev and Gentofte Hospital, University of Copenhagen, Denmark.

Local anesthetics are used throughout the health care system. In the perioperative setting and in other settings of exposure to local anesthetics, true allergy is reported very rarely. We present an unusual case of immediate-type perioperative hypersensitivity to lidocaine with cross-reaction to mepivacaine, which was missed on initial investigation. Read More

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http://dx.doi.org/10.1213/XAA.0000000000000955DOI Listing
January 2019
2 Reads

Analysis of the factors associated with diagnostic skin test positivity in immediate-type hypersensitivity reactions due to proton pump inhibitors.

Allergy 2019 Jan 11. Epub 2019 Jan 11.

Department of Chest Diseases, Division of Allergy and Immunology, Ankara University School of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.1111/all.13715DOI Listing
January 2019
4 Reads

[NSAID urticaria: Similar management to acute urticaria].

Rev Med Interne 2019 Mar 7;40(3):166-172. Epub 2019 Jan 7.

Service d'allergologie et immunologie clinique, hospices civils de Lyon, CHU Lyon-Sud, 69495 Pierre Bénite cedex, France; Université Lyon I, 69007 Lyon, France; - CIRI, Centre International de Recherche en Infectiologie, équipe 14, Univ Lyon, Inserm, U111, université Claude-Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007 Lyon, France. Electronic address:

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most common providers of immediate hypersensitivity reactions. Among these reactions, isolated acute urticaria is the most common clinical feature with a non-allergic origin. It is a pharmacological side effect resulting from the alteration of arachidonic acid metabolism induced by NSAIDs. Read More

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http://dx.doi.org/10.1016/j.revmed.2018.12.008DOI Listing
March 2019
2 Reads

Quality of life of the family of children with asthma is not related to asthma severity.

Eur J Pediatr 2019 Mar 4;178(3):369-376. Epub 2019 Jan 4.

Department of Public Health, Institute of Health Sciences, Faculty of Medicine, Vilnius University, Vilnius, M.K Ciurlionio str. 21, 03101, Vilnius, Lithuania.

The quality of life for the family is an important outcome of childhood asthma. The aim of the study was to describe the quality of life in families who have a child with asthma. The Pediatric Quality of Life Inventory Family Impact Module was completed by the parents of 527 children with asthma. Read More

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http://dx.doi.org/10.1007/s00431-018-3306-8DOI Listing
March 2019
4 Reads

The Diagnosis of Ceftriaxone Hypersensitivity in a Paediatric Population.

Int Arch Allergy Immunol 2019 3;178(3):272-276. Epub 2019 Jan 3.

Department of Paediatrics, Allergy Unit, Anna Meyer Children's University Hospital, Florence, Italy.

Introduction: Penicillins and cephalosporins are the most frequent causes of hypersensitivity reactions (HRs) to drugs in children. Among cephalosporins for intravenous use, ceftriaxone (CT) is the most frequently prescribed in Italy. The aims of this study were to evaluate the diagnostic methods for CT hypersensitivity in a population of children with suspected HRs to this drug and their tolerance toward amoxi-cillin/clavulanic acid (AMX/CLV). Read More

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http://dx.doi.org/10.1159/000495302DOI Listing
January 2019
2 Reads

[Severe and rare adverse reaction to hydrochlorothiazide].

Rev Alerg Mex 2018 Oct-Dec;65(4):442-445

Hospital Universitario Infanta Sofía, Departamento de Alergia, Madrid, España.

Background: The immune mechanism involved in the reaction to hydrochlorothiazide, which is widely used to control hypertension, is unknown. The short latency period between the take of the drug and the onset of symptoms suggests immediate hypersensitivity.

Case Report: 63-year-old woman with arterial hypertension who, on three occasions, experienced nausea, vomiting, general malaise, shivering, arthralgias, dysthermic sensation, back pain of mechanical characteristics and mild non-productive cough, as well as fever and chest tightness with increased dyspnea and desaturation of up to 88 %, after taking hydrochlorothiazide. Read More

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http://dx.doi.org/10.29262/ram.v65i4.363DOI Listing
January 2019
20 Reads

Immediate Hypersensitivity to Clindamycin: Rare, But Not Impossible.

J Allergy Clin Immunol Pract 2019 01;7(1):334-335

Department of Allergy, Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaip.2018.08.006DOI Listing
January 2019
3 Reads