19,042 results match your criteria Hypersensitivity Reactions Immediate

Efficacy of near infrared dental lasers on dentinal hypersensitivity: a meta-analysis of randomized controlled clinical trials.

Lasers Med Sci 2021 Aug 3. Epub 2021 Aug 3.

Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, 16132, Genoa, Italy.

Conventional therapies have aimed to try to help individuals suffering with dentine hypersensitivity (DH/DHS). A relatively new approach, laser therapy claims to be beneficial while having immediate and long-lasting effect. Therefore, our analysis aims to explore the immediate and 1-month efficacy of near-infrared laser (NIR) therapy in treating dentinal hypersensitivity. Read More

View Article and Full-Text PDF

Hypersensitivity reactions to monoclonal antibodies: Classification and treatment approach (Review).

Exp Ther Med 2021 Sep 3;22(3):949. Epub 2021 Jul 3.

Allergy Department, 'Professor Doctor Octavian Fodor' Regional Institute of Gastroenterology and Hepatology, 400000 Cluj-Napoca, Romania.

The present paper aims to review the topic of adverse reactions to biological agents, in terms of the incriminating mechanisms and therapeutic approach. As a result of immunomodulatory therapy, the last decade has achieved spectacular results in the targeted treatment of inflammatory, autoimmune, and neoplastic diseases, to name a few. The widespread use of biological agents is, however, associated with an increase in the number of observed adverse drug reactions ranging from local erythema to systemic reactions, including life-threatening immunologically mediated events, which justifies the need for a deeper understanding of this subject. Read More

View Article and Full-Text PDF
September 2021

Management of Eosinophilic Esophagitis During Oral Immunotherapy.

J Allergy Clin Immunol Pract 2021 Jul 27. Epub 2021 Jul 27.

Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Ga. Electronic address:

Food allergies are antigen-driven diseases that can lead to IgE-mediated reactions of immediate hypersensitivity (eg, anaphylaxis triggered by a single food) or non-IgE reactions of delayed hypersensitivity such as eosinophilic esophagitis (eg, inability to eat multiple foods manifesting as abdominal pain, choking, dysphagia, vomiting, reflux, food impaction). Although both types of disease have their own unique set of challenges in diagnosis and management, it is a particularly vexing problem when a patient is afflicted by both conditions. This situation can happen when individuals with IgE-mediated food allergy undergo desensitization using currently available forms of oral immunotherapy. Read More

View Article and Full-Text PDF

Patterns of response and drugs involved in hypersensitivity reactions to beta-lactams in children.

Pediatr Allergy Immunol 2021 Jul 29. Epub 2021 Jul 29.

Allergy Unit, Infanta Leonor University Hospital, Madrid, Spain.

Background: Beta-lactams generate different allergenic determinants that induce selective or cross-reactive drug hypersensitivity reactions (DHRs). We aimed to identify the drugs involved, the selectivity of the response, the mechanism, and the value of the different diagnostic tests for establishing a diagnosis in children evaluated for DHRs to beta-lactams.

Methods: Prospective study evaluating children aged under 16 years reporting DHRs to beta-lactams. Read More

View Article and Full-Text PDF

ESCAPE-Allergy: Evaluating screening for children and adolescents with penicillin allergy.

J Paediatr Child Health 2021 Jul 29. Epub 2021 Jul 29.

School of Women's and Children's Heath, University of New South Wales, Sydney, New South Wales, Australia.

Aim: Penicillin allergy labels are frequently encountered in children and are associated with significant harms. Most children are falsely labelled and can safely tolerate a penicillin but delabelling strategies are underutilised and paediatric-specific resources are lacking. The aim of this study was to evaluate an allergy assessment tool for children in hospital. Read More

View Article and Full-Text PDF

Hypersensitivity and Immune-related Adverse Events in Biologic Therapy.

Clin Rev Allergy Immunol 2021 Jul 28. Epub 2021 Jul 28.

Department of Medicine, Division of Rheumatology, Allergy, and Immunology, UNC School of Medicine, Chapel Hill, NC, USA.

Biologic medications are an expanding field of therapeutics for various medical conditions including cancer and inflammatory diseases. Due to their targeted approach to therapy, biologics can be less toxic than traditional systemic medications. However, as use becomes more widespread, adverse effects from biologic administration have also become apparent. Read More

View Article and Full-Text PDF

Polyethylene glycol allergy and immediate-type hypersensivitity reaction to COVID-19 vaccination: case report.

J Investig Allergol Clin Immunol 2021 Jul 26. Epub 2021 Jul 26.

Allergy and Clinical Immunology, General Internal Medicine, University Hospitals Leuven, Leuven, Belgium.

View Article and Full-Text PDF

Safety of direct oral provocation testing using the Amoxicillin-2-step-challenge in children with history of non-immediate reactions to amoxicillin.

World Allergy Organ J 2021 Jul 9;14(7):100560. Epub 2021 Jul 9.

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

Background: Previous studies have shown that direct oral provocation tests, without prior skin testing, in children having delayed onset, benign rashes to beta-lactam antibiotic is safe and effective. Although, this test is useful in confirming drug hypersensitivity reactions, there is no standard protocol recommendation of drug provocation tests. This study aimed to evaluate the safety of the direct oral provocation test, using the Amoxicillin-2-step-challenge without prior skin testing, in children with history of non-immediate reactions to amoxicillin. Read More

View Article and Full-Text PDF

Omega-5 and Gamma Gliadin are the Major Allergens in Adult-Onset IgE-Mediated Wheat Allergy: Results from Thai Cohort with Oral Food Challenge.

J Asthma Allergy 2021 15;14:907-917. Epub 2021 Jul 15.

Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Various clinical patterns based on routes of sensitization and sensitized allergens are reported in adult-onset IgE-mediated wheat allergy. There is still a paucity of data on IgE-bound wheat allergen profiles in wheat challenge-proven adult-onset wheat allergic cases. Therefore, we aim to identify the major sensitized allergens in Thai adult-onset wheat allergic patients whose first symptom occurred after the age of 18 years despite previous tolerance. Read More

View Article and Full-Text PDF

The roles of lipid mediators in type I hypersensitivity.

Tatsuro Nakamura

J Pharmacol Sci 2021 Sep 8;147(1):126-131. Epub 2021 Jun 8.

Department of Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan. Electronic address:

Type I hypersensitivity is an immediate immune reaction that involves IgE-mediated activation of mast cells. Activated mast cells release chemical mediators, such as histamine and lipid mediators, which cause allergic reactions. Recent developments in detection devices have revealed that mast cells simultaneously release a wide variety of lipid mediators. Read More

View Article and Full-Text PDF
September 2021

Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol.

Allergy Asthma Clin Immunol 2021 Jul 22;17(1):75. Epub 2021 Jul 22.

Department of Medicine, University of Toronto, Toronto, ON, Canada.

Background: Immediate hypersensitivity reaction to ursodiol is rare and there is no previously published protocol on ursodiol desensitization.

Case Presentation: A 59-year-old woman with primary biliary cholangitis (PBC) developed an immediate hypersensitivity reaction to ursodiol-the first-line treatment for PBC. When she switched to a second-line treatment, her PBC continued to progress. Read More

View Article and Full-Text PDF

Establishing amoxicillin allergy in children through direct graded oral challenge (GOC): evaluating risk factors for positive challenges, safety, and risk of cross reactivity to cephalosporines.

J Allergy Clin Immunol Pract 2021 Jul 19. Epub 2021 Jul 19.

Division of Allergy and Clinical Immunology, Department of Pediatrics, Montreal Children's Hospital, Montreal, Quebec, Canada; Infectious Diseases and Immunity in Global Health Program, The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada.

Background: Data on the diagnostic properties of direct oral challenges without the use of skin tests in children with suspected amoxicillin allergy is sparse.

Objective: Assess the use of direct oral challenges.

Methods: A cohort study was conducted between March 2013 and March 2020, in Montreal and Winnipeg. Read More

View Article and Full-Text PDF

Detection of drug-specific immunoglobulin E (IgE) and acute mediator release for the diagnosis of immediate drug hypersensitivity reactions.

Knut Brockow

J Immunol Methods 2021 Sep 14;496:113101. Epub 2021 Jul 14.

Department of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, Germany. Electronic address:

The diagnosis of a drug hypersensitivity reaction (DHR) is complex. The first step after taking the clinical history is to look for a sensitization to confirm or exclude the diagnosis and to identify the culprit drug. Skin tests are the primary means of detecting sensitization in DHR, but are associated with a risk for a severe reaction and may be contraindicated. Read More

View Article and Full-Text PDF
September 2021

Predictive factors of amoxicillin immediate hypersensitivity and validation of PEN-FAST clinical decision rule.

Ann Allergy Asthma Immunol 2021 Jul 13. Epub 2021 Jul 13.

Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.

Background: The challenge of delabeling amoxicillin allergy is an important issue for patients and clinicians, especially when anaphylaxis is reported. A recent study has proposed a clinical decision rule, PEN-FAST, to identify low-risk penicillin allergies.

Objective: To validate the PEN-FAST clinical decision rule in a population with high risk of suspected immediate amoxicillin allergy and to identify clinical predictive factors of amoxicillin immediate hypersensitivity. Read More

View Article and Full-Text PDF

Methylprednisolone-induced anaphylaxis diagnosed by intradermal skin test: a case report.

Allergy Asthma Clin Immunol 2021 Jul 13;17(1):70. Epub 2021 Jul 13.

Department of Pediatrics, School of Medicine, Aichi Medical University, 1-1, Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.

Background: Glucocorticoids rarely cause anaphylaxis. Common methods for the determination of allergens include in vivo skin prick test (SPT) and intradermal skin test (IDST) and the in vitro basophil activation test (BAT). However, to our knowledge, the best strategy for diagnosing glucocorticoid-induced anaphylaxis has not been elucidated. Read More

View Article and Full-Text PDF

Anaphylaxis to levetiracetam in an adolescent: a very rare occurence.

Turk J Pediatr 2021 ;63(3):506-509

Divisions of Pediatric Allergy, Gazi University Faculty of Medicine, Ankara, Turkey.

Background: Antiepileptic drugs (AEDs) are among the most common causes of severe delayed-type hypersensitivity reactions such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and Drug Reaction with Eosinophilia and Systemic Symptoms(DRESS) in children. These reactions are more commonly seen with aromatic AEDs such as phenytoin and carbamazepine than the non-aromatic or new generation AEDs. However immediate-type hypersensitivity reactions such as urticaria/angioedema, anaphylaxis are very rare with AEDs. Read More

View Article and Full-Text PDF
January 2021

Perioperative Anaphylaxis: Evaluation and Management.

Clin Rev Allergy Immunol 2021 Jul 10. Epub 2021 Jul 10.

Division of Allergic Diseases, Mayo Clinic, Rochester, MN, 55905, USA.

Perioperative anaphylaxis (PA) is a rare but life-threatening condition that poses diagnostic and management challenges in the operating room. The incidence of severe perioperative reactions is estimated to be approximately 1:7000-10,000. Management involves both immediate stabilization of the patient and identifying the culprit agent. Read More

View Article and Full-Text PDF

Associations between HLA-A, -B, and -C alleles and iodinated contrast media-induced hypersensitivity in Koreans.

Transl Clin Pharmacol 2021 Jun 15;29(2):107-116. Epub 2021 Jun 15.

Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan 47392, Korea.

A common cause of drug hypersensitivity reactions is iodinated contrast media (ICM). ICM-induced hypersensitivity had been considered to be a non-immunological reaction, but evidence for an immunological mechanism has increased recently. Thus, we evaluated whether HLA-A, -B, and -C alleles were associated with ICM-induced hypersensitivity. Read More

View Article and Full-Text PDF

Mast cell activation tests by flow cytometry: A new diagnostic asset?

Clin Exp Allergy 2021 Jul 7. Epub 2021 Jul 7.

Department of Immunology - Allergology - Rheumatology, Faculty of Medicine and Health Science and the Infla-Med Centre of Excellence, University of Antwerp, Antwerp University Hospital, Antwerp, Belgium.

Since the late nineties, evidence has accumulated that flow-assisted basophil activation test (BAT) might be an accessible and reliable method to explore the mechanisms governing basophil degranulation and diagnostic allowing correct prediction of the clinical outcome following exposure to the offending allergen(s) and cross-reactive structures for different IgE-dependent allergies and particular forms of autoimmune urticaria. Although the BAT offers many advantages over mediator release tests, it is left with some weaknesses that hinder a wider application. It is preferable to perform the BAT analysis within 4 h of collection, and the technique does not advance diagnosis in patients with non-responsive cells. Read More

View Article and Full-Text PDF

Hypersensitivity reactions to iodinate contrast media in Italy: a retrospective study. Characteristics of patients and risk factors.

Eur Ann Allergy Clin Immunol 2021 Jul 6. Epub 2021 Jul 6.

Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.

Summary: The purpose of the study was to describe the characteristics of patients experiencing hypersensitivity reactions (HRs) to iodinated contrast media (ICM) in a large Italian population and to investigate potential risks factors in order to obtain a risk stratification, helpful in the management of these patients. Data of 407 patients investigated in 9 Italian Allergy Centers for suspected HRs to ICM were analyzed and compared with a control group of 152 subjects that tolerated one or more ICM-enhanced examinations. The univariate and multivariate logistic regression model was used to evaluate associated factors. Read More

View Article and Full-Text PDF

Drug Allergy and Cutaneous Adverse Reactions.

Maja Mockenhaupt

Handb Exp Pharmacol 2021 Jul 5. Epub 2021 Jul 5.

Dokumentationszentrum schwerer Hautreaktionen (dZh), Department of Dermatology, Medical Center and Medical Faculty, University of Freiburg, Freiburg, Germany.

Allergy or hypersensitivity to drugs often affects the skin and sometimes also mucosa. While immediate type reactions show a rather homogeneous pattern, delayed type reactions reveal a high variability. In both cases it may not always be easy to differentiate drug reactions from non-drug-induced skin conditions. Read More

View Article and Full-Text PDF

Lymphocyte transformation test and cytokine detection assays: Determination of read out parameters for delayed-type drug hypersensitivity reactions.

J Immunol Methods 2021 Sep 30;496:113098. Epub 2021 Jun 30.

Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Salaya, Thailand. Electronic address:

Drug hypersensitivity reactions (DHRs) occur in certain people and are often not predictable. DHRs can be classified as immediate and delayed reactions regarding to onset of clinical manifestations. Both reactions are considered to be an important public health problem because they can lead to life-threatening conditions; however, this review article will focus on delayed DHRs. Read More

View Article and Full-Text PDF
September 2021

One-Dilution Rapid Desensitization Protocol to Chemotherapeutic and Biological Agents: A Five-Year Experience.

J Allergy Clin Immunol Pract 2021 Jun 30. Epub 2021 Jun 30.

Allergy Section, Internal Medicine Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain; ARADyAL Research Network, Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Vall d'Hebron Institut de Recerca (VHIR), Immunomediated Diseases and Innovative Therapies, Barcelona, Spain; Universitat Autònoma de Barcelona (UAB), Medicine Department, Barcelona, Spain.

Background: Rapid drug desensitization (RDD) becomes a crucial procedure to allow treatment continuation in patients who suffer drug hypersensitivity reactions (DHRs) to chemotherapeutic (CMT) and biological agents (BA).

Objective: The aim of the study was to compare the efficacy and safety of a one-bag dilution protocol (1DP) with a conventional three-bag dilution protocol (3DP) for desensitization of patients with CMT or BA hypersensitivity.

Methods: Retrospective analysis of patients with immediate DHRs to CMT or BA who underwent at least 1 RDD procedure in our department between 2014 and 2019 was performed. Read More

View Article and Full-Text PDF

Sulfonamide Hypersensitivity.

Clin Rev Allergy Immunol 2021 Jul 1. Epub 2021 Jul 1.

Division of Allergy and Immunology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Sulfonamides, particularly antimicrobial sulfonamides, have been implicated as a common cause of a spectrum of hypersensitivity reactions. Immediate IgE-mediated reactions have been reported but are much less common than delayed cutaneous reactions. Delayed cutaneous reactions range from benign exanthems to severe cutaneous reactions such as Stevens Johnson syndrome, toxic epidermal necrolysis, or drug reaction with eosinophilia and systemic symptoms. Read More

View Article and Full-Text PDF

Immediate Dentin Sealing: A Literature Review.

Clin Cosmet Investig Dent 2021 21;13:233-256. Epub 2021 Jun 21.

Department of Prosthodontics, National and Kapodistrian University of Athens, Athens, Greece.

Purpose: The immediate application of a dentin-bonding agent after tooth preparation and before impression-taking (immediate dentin sealing [IDS]) has been suggested to provide several advantages concerning bacterial microleakage, hypersensitivity, and bonding quality. We reviewed the literature and clarified certain aspects related to each step of IDS application.

Materials And Methods: The search strategy comprised an electronic research in MEDLINE, Cochrane, Ovid and Scopus for studies published from January 1990 to December 2020 regarding the IDS technique and including both in vitro and clinical studies. Read More

View Article and Full-Text PDF

Acute Urticaria in Inpatients Undergoing Non-emergent Coronary Angiography With Corticosteroid Prophylaxis: A Retrospective Study.

Front Med (Lausanne) 2021 10;8:616015. Epub 2021 Jun 10.

Department of Dermatology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Acute urticaria (AU) is the most frequently reported immediate hypersensitivity reaction in skin by administration of iodinated contrast media (ICM). We aimed to establish the pattern and identify the risk factors of AU among inpatients undergoing non-emergent coronary angiography (CAG) with prophylactic corticosteroids in China. Medical records of 19,326 adult inpatients undergoing non-emergent CAG with prophylactic methylprednisolone in 2013-2019 were retrospectively investigated. Read More

View Article and Full-Text PDF

Multiplexed analytical approaches to beta-lactam allergy in vitro testing standardization.

Anal Chim Acta 2021 Aug 25;1173:338656. Epub 2021 May 25.

Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València-Universitat de València, Camino de Vera S/n, 46022, Valencia, Spain; Departamento de Química, Universitat Politècnica de València, Camino de Vera S/n, 46022, Valencia, Spain; Unidad Mixta UPV-La Fe, Nanomedicine and Sensors, IIS La Fe, Av. Fernando Abril Martorell, 46026, Valencia, Spain. Electronic address:

The suspicion of beta-lactam allergy directly contributes to the prescription of antibiotics that diverge from the guidelines, increasing antimicrobial resistance, one of the biggest threats to global health. In vitro quantification of specific IgE is very useful for monitoring allergy, as it confirms or rules out immediate beta-lactam drug allergy and helps find safe alternative antibiotic stewardship. However, reliable in vitro quantification of specific IgE to beta-lactam antibiotics by immunoassay is challenging because of the difficulty of having selective immunoreagents, mainly beta-lactam antigens, and its low concentration levels in serum. Read More

View Article and Full-Text PDF

Successful Rapid Oral Desensitization to Ibrutinib in a Patient With Severe Immediate Hypersensitivity Reaction.

Clin Lymphoma Myeloma Leuk 2021 May 24. Epub 2021 May 24.

Division and Central Laboratory of Hematology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne.

View Article and Full-Text PDF

Immediate-Type Hypersensitivity to Polyethylene Glycol (PEG) Including a PEG-containing COVID-19 Vaccine Revealed by Intradermal Testing.

J Investig Allergol Clin Immunol 2021 Jun 15. Epub 2021 Jun 15.

Clinical&Experimental Allergology, Department of Dermatology and Allergology, Philipps-Universität Marburg, Marburg, Germany.

View Article and Full-Text PDF

Comparison of Four Different Allergy Tests in Equine Asthma Affected Horses and Allergen Inhalation Provocation Test.

J Equine Vet Sci 2021 07 17;102:103433. Epub 2021 Mar 17.

Free University of Berlin, Department of Veterinary Medicine, Equine Clinic, Surgery and Radiology, Berlin, Germany. Electronic address:

Potential triggers for equine asthma are allergens from hay and straw dusts, mold spores and storage mites. The contribution of these environmental trigger factors to equine asthma is still largely uncertain. The aim of this study was to compare results of four allergy tests from healthy and asthma-affected horses, and to evaluate the clinical relevance of allergens tested positive via specific inhalation provocation test. Read More

View Article and Full-Text PDF