19,448 results match your criteria Hypersensitivity Reactions Immediate


Harefuah 2022 Aug;161(8):481-486

Department of Internal Medicine "T", Chaim Sheba Medical Center, Tel-Hashomer.

Introduction: A male patient aged 81, with a history of atrial fibrillation, pacemaker implantation and hip replacement was admitted due to pneumonia. Subsequent Methicillin Sensitive Staphylococcus Aureus (MSSA) bacteremia and septic arthritis of his prosthetic joint was diagnosed, and treated with Oxacillin. Two weeks later, an exanthematous rash appeared, involving most of his body surface, evolving to blisters that dried up and led to extensive exfoliation of the skin, consistent with a delayed type hypersensitivity drug reaction. Read More

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Ant sting-induced whole-body pustules in an inebriated male: A case report.

World J Clin Cases 2022 Jul;10(19):6695-6701

Department of Dermatology, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China.

Background: Many ant species can harm humans; however, only a few cause life-threatening allergic reactions. Normally, reactions caused by ants occur in patients who come into contact with ant venom. Venom contains various biologically active peptides and protein components, of which acids and alkaloids tend to cause anaphylaxis. Read More

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"Drugs and the Skin" A concise review of cutaneous adverse drug reactions.

Br J Clin Pharmacol 2022 Aug 16. Epub 2022 Aug 16.

Department of Pediatrics, Division of Dermatology and Rheumatology, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.

Drug-induced skin disease or cutaneous adverse drug reactions (CADRs) are terms that encompass the clinical manifestations of the skin, mucosae and adnexa induced by a drug or its metabolites. The skin is the organ most frequently affected by drug reactions, which may affect up to 10% of hospitalized patients and occur in 1% to 3% of multi-medicated patients. Most CADRs are mild or self-resolving conditions; however, 2% to 6. Read More

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Development of mouse model for oral allergy syndrome to identify IgE cross-reactive pollen and food allergens: ragweed pollen cross-reacts with fennel and black pepper.

Front Immunol 2022 25;13:945222. Epub 2022 Jul 25.

Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Oral allergy syndrome (OAS) is an IgE-mediated immediate food allergy that is localized to the oral mucosa. Pollen food allergy syndrome (PFAS), a pollinosis-associated OAS, is caused by cross-reactivity between food and pollen allergens. However, we need to more precisely understand the underlying pathogenesis of OAS/PFAS. Read More

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Incidence and Risk Factors of Immediate Hypersensitivity Reactions and Immunisation Stress-related Responses with COVID-19 mRNA Vaccine.

J Allergy Clin Immunol Pract 2022 Aug 8. Epub 2022 Aug 8.

Self-Defence Forces Tokyo Large-scale Vaccination Centre, Tokyo, Japan; Self-Defence Forces Central Hospital, Department of Urology, Tokyo, Japan.

Background: With the implementation of mass vaccination campaigns against COVID-19, the safety of vaccine needs to be evaluated.

Objective: We aimed to assess the incidence and risk factors for immediate hypersensitivity reactions (IHSR) and immunisation stress-related responses (ISRR) with the Moderna COVID-19 vaccine.

Methods: This nested case-control study included recipients who received the Moderna vaccine at a mass vaccination centre, Japan. Read More

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Re-vaccination and adverse event recurrence in patients with adverse events following immunization.

J Pediatr 2022 Aug 7. Epub 2022 Aug 7.

Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada; Canadian Center for Vaccinology, IWK Health, Nova Scotia Health, and Dalhousie University, Halifax, Nova Scotia, Canada; Department of Pediatrics, Dalhousie University. Electronic address:

Objectives: To estimate the risk of recurrence of adverse events following immunization (AEFIs) upon re-vaccination and to determine among patients with suspected vaccine allergy whether allergy skin test positivity was associated with AEFI recurrence.

Study Design: This prospective observational study included patients assessed in the Canadian Special Immunization Clinic (SIC) Network from 2013 to 2019 with AEFIs who required re-vaccination with the vaccine temporally associated with their AEFI. Participants underwent standardized assessment and data collection. Read More

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Eyelid edema following the first Pfizer-BioNTech COVID-19 vaccination: is it a coincidence?

Z Baysal H H Gobeka

Eur Rev Med Pharmacol Sci 2022 Jul;26(14):5264-5267

Ophthalmology Clinic, Batman Educational and Research Hospital, Batman, Turkey.

Objective: This report describes an ocular allergic reaction manifested as eyelid edema after Pfizer-BioNTech COVID-19 vaccination.

Case Description: A 28-year-old female had the first Pfizer-BioNTech COVID-19 vaccine dose and was discharged following a 20-minute post-vaccination observation for potential adverse complications. She came to the emergency department after her left eyelid swelled unexpectedly two hours later, accompanied by itching and redness. Read More

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[Allergy Diagnostics 2021].

Petra Zieglmayer

Laryngorhinootologie 2022 08 1;101(8):673-686. Epub 2022 Aug 1.

Allergic diseases are among the most common diseases worldwide. For appropriate management knowledge of the allergy trigger is crucial. The clinical picture of allergic diseases is diverse and correct diagnosis is often a challenge. Read More

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Basophil Activation Test as a Biomarker for Taxanes Anaphylaxis.

Front Allergy 2022 13;3:787749. Epub 2022 Jul 13.

Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital (BWH), Harvard Medical School, Boston, MA, United States.

Introduction: Taxanes are widely used chemotherapy agents, and their administration, despite premedication, is associated with hypersensitivity reactions (HR) in up to 9% of patients, 1% of which are severe. The mechanisms of these reactions are not fully understood. Finding biomarkers for early diagnosis and better understanding the underlying mechanisms of these reactions are key to defining the best treatment strategy for patients. Read More

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Incidence of immediate allergic reactions to mRNA COVID-19 vaccines in adults with drug allergies and other allergic disorders.

Medicine (Baltimore) 2022 Jul 29;101(30):e29571. Epub 2022 Jul 29.

Special Hospital for Pulmonary Diseases, Zagreb, Croatia.

Concerns have been raised about allergic reactions to messenger ribonucleic acid (mRNA) coronavirus disease 2019 (COVID-19) vaccines. A history of allergic reactions, including anaphylaxis to drugs, has been frequently reported in individuals with anaphylaxis to mRNA vaccines. To estimate the rate of immediate allergic reactions in patients with a history of drug allergy or other allergic disorders. Read More

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Evidence underscoring immunological and clinical pathological changes associated with Sarcoptes scabiei infection: synthesis and meta-analysis.

BMC Infect Dis 2022 Jul 28;22(1):658. Epub 2022 Jul 28.

Department of Biological Sciences, University of Tasmania, Private Bag 55, Hobart, TAS, Australia.

Background: Sarcoptes scabiei is one of the most impactful mammalian parasites. There has been much research on immunological and clinical pathological changes associated with S. scabiei parasitism across a range of host species. Read More

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Breastfeeding and Allergy Effect Modified by Genetic, Environmental, Dietary, and Immunological Factors.

Nutrients 2022 Jul 22;14(15). Epub 2022 Jul 22.

1st Clinical Department of Pediatrics, Allergology and Cardiology, Wroclaw Medical University, ul. Chałubińskiego 2a, 50-368 Wrocław, Poland.

Breastfeeding (BF) is the most natural mode of nutrition. Its beneficial effect has been revealed in terms of both the neonatal period and those of lifelong effects. However, as for protection against allergy, there is not enough data. Read More

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Comparison of Pulmonary Function and Inflammation in Children/Adolescents with New-Onset Asthma with Different Adiposity Statuses.

Nutrients 2022 Jul 20;14(14). Epub 2022 Jul 20.

Department of Respiratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, No. 1678 Dongfang Road, Pudong, Shanghai 200127, China.

(1) Background: The relationship between obesity and asthma is still uncertain. This study aimed to investigate the effect of overweight/obesity on the pulmonary function of patients with new-onset pediatric asthma and explore the possible causative factors related to concomitant obesity and asthma. (2) Methods: Patients aged 5 to 17 years old with newly diagnosed mild to moderate asthma were recruited from June 2018 to May 2019, from a respiratory clinic in Shanghai, China. Read More

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Changes in Sensitization Patterns in the Last 25 Years in 619 Patients with Confirmed Diagnoses of Immediate Hypersensitivity Reactions to Beta-Lactams.

Biomedicines 2022 Jun 28;10(7). Epub 2022 Jun 28.

Allergy Service, University Hospital of Salamanca, 37007 Salamanca, Spain.

Beta-lactam (BL) drugs are the antibiotics most prescribed worldwide due to their broad spectrum of action. They are also the most frequently implied in hypersensitivity reactions with a known specific immunological mechanism. Since the commercialization of benzylpenicillin, allergic reactions have been described; over the years, other new BL drugs provided alternative treatments to penicillin, and amoxicillin is now the most prescribed BL in Europe. Read More

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Assessment and management of allergy history with a novel mRNA vaccine.

Ann Fam Med 2022 04 1;20(20 Suppl 1). Epub 2022 Apr 1.

Context: Tertiary care hospital provided onsite COVID-19 vaccine roll out as a work benefit for all care team members with medically supervised waiting period at the time of the distribution of the first round of the novel mRNA COVID-19 vaccines. Little was known about the immediate hypersensivity reactions or what might predispose to cross reactivity.

Objective: We developed a working protocol to continuously track the vaccines administered, the patient history of allergy and hypersensistivity, the reactions observed and the care plan developed (determination of allergy to mRNA vaccines or normal vaccine response). Read More

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Current and Future Strategies for the Diagnosis and Treatment of the Alpha-Gal Syndrome (AGS).

J Asthma Allergy 2022 18;15:957-970. Epub 2022 Jul 18.

SaBio (Health and Biotechnology), Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ciudad Real, 13005, Spain.

The α-Gal syndrome (AGS) is a pathognomonic immunoglobulin E (IgE)-mediated delayed anaphylaxis in foods containing the oligosaccharide galactose-α-1,3-galactose (α-Gal) such as mammalian meat or dairy products. Clinical presentation of AGS can also comprise immediate hypersensitivity due to anticancer therapy, gelatin-containing vaccines or mammalian serum-based antivenom. The IgE initial sensitization is caused by hard-bodied tick bites and symptomatic individuals typically develop delayed pruritus, urticaria, angioedema, anaphylaxis, malaise or gut-related symptoms. Read More

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Cross-reactivity of each fraction among cereals in children with wheat allergy.

Pediatr Allergy Immunol 2022 07;33(7):e13831

Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Kanagawa, Japan.

Background: Cross-reactivity between wheat and other cereals is a crucial issue in the management of wheat allergy. Few studies have reported in vitro cross-reactivity in immediate-type wheat allergy. The aim of this study aimed to examine cross-reactivity of the three fractions (albumin/globulin, gliadin, and glutenin fractions) among cereals in children with wheat allergy. Read More

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Adrenomedullin is an Important Pathological Mediator in Progression of Chronic Neuropathic Pain.

Front Biosci (Landmark Ed) 2022 Jul;27(7):220

Provincial Key Laboratory of Developmental Biology and Neuroscience, College of Life Sciences, Fujian Normal University, 350117 Fuzhou, Fujian, China.

Background: The characterization of neuropathic pain is maladaptive plasticity within the nociceptive system. Multiple alterations contribute to complex pain phenotypes. Adrenomedullin (AM) has been documented to be a pain mediator. Read More

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Contrast induced acute hypersensitivity reaction in a 10-year-old patient: A rare case study.

Ann Med Surg (Lond) 2022 Aug 9;80:104136. Epub 2022 Jul 9.

Department of Pharmacy Practice, St Pauls College of Pharmacy, Turkayamjal, Hyderabad, India.

Background: Immediate skin rashes, flushing, or urticarial pruritus, rhinorrhea, nausea, short retching, and/or vomiting, diaphoresis, coughing, and vertigo are all symptoms of mild hypersensitivity reactions with an incidence of 3%.

Case Presentation: A 10-year old male child presented with acute hypersensitivity reaction due to the contrast used during the CECT scan.

Discussion: Contrast should always be used in caution with children. Read More

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Management of adverse reactions induced by chemotherapy drugs.

Curr Opin Allergy Clin Immunol 2022 08;22(4):221-225

Serviço de Imunoalergologia, Centro Hospitalar Universitário São João.

Purpose Of Review: There is a broad spectrum of chemotherapy-induced adverse reactions. Hypersensitivity reactions are being extensively studied as they can affect the ideal treatment. The goal of this review is to describe the current management of adverse reactions to chemotherapy, focusing on hypersensitivity events. Read More

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Iodinated Contrast Media Substitution to Prevent Recurrent Hypersensitivity Reactions: A Systematic Review and Meta-Analysis.

Radiology 2022 Jul 19:220370. Epub 2022 Jul 19.

From the Department of Radiology, Anjo Kosei Hospital, Anjo, Japan (H.U.); Department of Radiology, National Center for Geriatrics and Gerontology, Obu, Japan (T.N.); Department of Radiology, Toyohashi Municipal Hospital, Toyohashi, Japan (A.T.); Department of Radiology, Komaki City Hospital, Komaki, Japan (N.H.); Department of Radiology, Nagoya University Hospital, Nagoya, Japan (S.I.); Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (Y.T., S.N.); Departments of Radiology and Urology, Michigan Medicine, Ann Arbor, Mich (M.S.D.); and Section of General Internal Medicine, Department of Emergency and General Internal Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukakecho, Toyoake 470-1192, Japan (T.T.).

Background Changing iodinated contrast media (ICM) may reduce the risk of recurrent ICM-induced hypersensitivity reactions in patients with a prior reaction. Purpose To perform a systematic review on the effectiveness of ICM change in comparison with no change to prevent recurrent ICM immediate hypersensitivity reactions. Materials and methods Multiple data bases were searched without language restriction between January 1990 and August 2021 to identify comparative studies of any design that included patients with a prior ICM hypersensitivity reaction to low-osmolality ICM and re-exposure to intravascular ICM. Read More

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COVID vaccination can be performed in patients with a history of allergic reactions to the vaccines or their components: experience from a specialist clinic in South Australia.

Intern Med J 2022 Jul 18. Epub 2022 Jul 18.

Immunology Department, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Background: The development of vaccines against SARS-CoV2 has been a key public health response to the COVID-19 pandemic. However, since their introduction, there have been reports of anaphylactic reactions to vaccines in individuals with history of allergic reactions to other vaccines, excipients or to COVID vaccines.

Aim: A dedicated adult COVID vaccine allergy clinic with a standardised allergy testing protocol was set up to investigate safety and suitability of available COVID vaccines in Australia. Read More

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Diagnosis and Prevention of Hypersensitivity Reactions to Iodinated Contrast Media.

Allergy Asthma Immunol Res 2022 Jul;14(4):348-360

Department of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, Germany.

Iodinated contrast media (ICM) have become one of the major causes of drug hypersensitivity reactions (HSRs) related to increasing numbers of ICM-based radiological imaging procedures. Strategies for diagnosing and preventing ICM-induced HSRs have not been uniformly standardized yet. However, advances have been made based on the results of recent research. Read More

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Remdesivir-induced non-immediate cutaneous hypersensitivity reaction.

J Investig Allergol Clin Immunol 2022 Jul 14. Epub 2022 Jul 14.

Department of Allergy, Hospital Universitario 12 de Octubre, Madrid, Spain.

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Antibiotic allergy in children with cystic fibrosis: A retrospective case-control study.

Pediatr Pulmonol 2022 Jul 14. Epub 2022 Jul 14.

Division of Pediatric Allergy and Immunology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Antibiotic allergy is a big problem that may affect the treatment and life quality of patients with cystic fibrosis (CF).

Aim: To evaluate predictive factors for confirmed antibiotic hypersensitivity in children with CF.

Methods: In this case-controlled study, we examined 15 patients with CF who had been confirmed with antibiotic allergy. Read More

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Non-immediate hypersensitivity reactions to iomeprol: Diagnostic value of skin tests and cross-reactivity with other iodinated contrast media.

Allergy 2022 Jul 11. Epub 2022 Jul 11.

Servicio de Alergia, Hospital Universitario Cruces, Barakaldo, Spain.

Background: Iodinated contrast media produce non-immediate hypersensitivity reactions (NIHR). The goal of this prospective study was to determine the utility of skin tests and the subsequent tolerance to negative skin-tested iodinated contrasts in patients with NIHR caused by iomeprol.

Methods: Prick and intradermal tests with iomeprol, iopamidol, iopromide, and iobitridol were performed in all patients. Read More

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Detection of Serum-Specific IgE by Fluoro-Enzyme Immunoassay for Diagnosing Type I Hypersensitivity Reactions to Penicillins.

Int J Mol Sci 2022 Jun 23;23(13). Epub 2022 Jun 23.

Oasi Research Institute-IRCCS, 94018 Troina, Italy.

Diagnosis of type I hypersensitivity reactions (IgE-mediated reactions) to penicillins is based on clinical history, skin tests (STs), and drug provocation tests (DPTs). Among in vitro complementary tests, the fluoro-enzyme immunoassay (FEIA) ImmunoCAP (Thermo-Fisher, Waltham, MA, USA) is the most widely used commercial method for detecting drug-specific IgE (sIgE). In this study, we aimed to analyze the utility of ImmunoCAP for detecting sIgE to penicillin G (PG) and amoxicillin (AX) in patients with confirmed penicillin allergy. Read More

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Nociplastic Pain in Multiple Sclerosis Spasticity: Dermatomal Evaluation, Treatment with Intradermal Saline Injection and Outcomes Assessed by 3D Gait Analysis: Review and a Case Report.

Int J Environ Res Public Health 2022 Jun 27;19(13). Epub 2022 Jun 27.

Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.

Nociplastic pain has been introduced by the IASP as a third category of pain, distinct from nociceptive and neuropathic pain. Pathogenetically, it is considered to be a continuum of these two types of pain after becoming chronic. Repetitive peripheral painful stimulation causes a central sensitization with hypersensitivity of the corresponding spinal metamer or brain region. Read More

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Amoxicillin hypersensitivity: Patient outcomes in a seven-year retrospective study.

Ann Allergy Asthma Immunol 2022 Jul 2. Epub 2022 Jul 2.

Department of Adult Allergy, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.

Background: The beta-lactam antibiotic amoxicillin and the beta-lactamase inhibitor clavulanic acid in combination with amoxicillin are known to cause both immediate- and nonimmediate-type hypersensitivity.

Objective: To characterize a large cohort of patients with a history of amoxicillin or amoxicillin-clavulanic acid hypersensitivity.

Methods: A retrospective analysis was conducted of the demographics, presentation, investigation, and management of 331 patients presenting to 1 allergy center with a history of hypersensitivity to amoxicillin or amoxicillin-clavulanic acid. Read More

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Delayed-Type Heparin Allergy: Intravenous Tolerance Despite Inflammatory Skin Reaction After Subcutaneous Injection.

J Allergy Clin Immunol Pract 2022 Jul 2. Epub 2022 Jul 2.

Department of Dermatology and Allergy, University Hospital Würzburg, Würzburg, Germany.

Background: Heparin allergy most frequently manifests as delayed-type hypersensitivity (DTH) causing an itchy inflammatory skin reaction at the site of subcutaneous injection. An important differential diagnosis is circumscribed skin necrosis due to heparin-induced thrombocytopenia.

Objectives: An inflammatory skin reaction to subcutaneously injected heparin generally entails the quest for alternative anticoagulation; concerns may particularly arise in an emergency situation requiring intravenous heparin administration. Read More

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