18,628 results match your criteria Hypersensitivity Reactions Immediate


Allergy against Steroids in Ocular Inflammation.

Ocul Immunol Inflamm 2020 Jul 9:1-6. Epub 2020 Jul 9.

Research Group in Neurosciences NeURos. Escuela De Medicina Y Ciencias De La Salud, Universidad Del Rosario , Bogotá, Colombia.

Allergy to steroids is an uncommon and harmful condition that leads to a decrease in treatment options and increase in morbidity due to the suboptimal disease control. It can manifest as an immediate response or a delay manifestation. Worsening of underlying condition and not treatment response can indicate corticosteroids hypersensitivity as well. Read More

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http://dx.doi.org/10.1080/09273948.2020.1766511DOI Listing

CDK8 is associated with RAP2.6 and SnRK2.6 and positively modulates abscisic acid signaling and drought response in Arabidopsis.

New Phytol 2020 Jul 3. Epub 2020 Jul 3.

Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN, 47907, USA.

CDK8 is a key subunit of Mediator complex, a large multi-protein complex that is a fundamental part of the conserved eukaryotic transcriptional machinery. However, the biological functions of CDK8 in plant abiotic stress responses remain largely unexplored. Here, we demonstrated CDK8 as a critical regulator in the ABA signaling and drought response pathways in Arabidopsis. Read More

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http://dx.doi.org/10.1111/nph.16787DOI Listing

Shuxuening injection, derived from leaf, induced pseudo-allergic reactions through hyperactivation of mTOR.

Pharm Biol 2020 Dec;58(1):581-589

Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

Shuxuening injection (SXNI), derived from the leaf of G L. (Ginkgoaceae), is widely used to treat cardio-cerebral vascular system related disease due to the efficacy of dilating the blood vessels and improving the function of microcirculation. Nevertheless, SXNI induces immediate hypersensitivity reactions in clinics and the molecular mechanisms are unknown. Read More

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http://dx.doi.org/10.1080/13880209.2020.1784238DOI Listing
December 2020

Type I allergic reaction to rituximab upon first lifetime exposure: a case report.

Allergy Asthma Clin Immunol 2020 26;16:56. Epub 2020 Jun 26.

Division of Allergy and Clinical Immunology, Department of Medicine, McGill University Health Centre, McGill University, Montreal, QC Canada.

Background: While drug reactions to rituximab have been commonly reported in the literature, a type I allergic reaction to rituximab after first lifetime exposure has never been reported.

Case Presentation: We describe a case of a 58-year-old female patient who received rituximab for the first time for treatment of rheumatoid arthritis. She developed symptoms immediately after infusion, however presented 11 days after drug exposure with cyclical anaphylaxis-like reaction requiring multiple doses of epinephrine. Read More

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http://dx.doi.org/10.1186/s13223-020-00448-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318363PMC

Immediate hypersensitivity reactions to steroids and steroid containing medications.

Curr Opin Allergy Clin Immunol 2020 Aug;20(4):362-366

Department of Respiratory Diagnostics and Bronchofiberoscopy, Medical University, Bialystok, Poland.

Purpose Of Review: Although rare and counterintuitive, hypersensitivity reactions to corticosteroids have been reported since the 1950s. Delayed hypersensitivity reactions following cutaneous exposure (contact allergy) are well understood and principles of testing, as well as cross-reactivity patterns, have been established. In contrast, understanding of immediate hypersensitivity reactions and delayed hypersensitivity reactions after systemic exposure is evolving more slowly. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000655DOI Listing

Adverse reactions to vancomycin and cross-reactivity with other antibiotics.

Curr Opin Allergy Clin Immunol 2020 Aug;20(4):352-361

Department of Infectious Diseases, Centre for Antibiotic Allergy and Research, Austin Health.

Purpose Of Review: Glycopeptide antibiotics such as vancomycin are frequently utilized to treat resistant Gram-positive infections such as methicillin-resistant Staphylococcus aureus. The current literature on glycopeptide and lipoglycopeptide structure, hypersensitivity and potential cross-reactivity was reviewed, highlighting implications for safe prescribing.

Recent Findings: Structurally similar, glycopeptides could theoretically cross-react. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000665DOI Listing

Natural products targeting FcεRI receptor for anti-allergic therapeutics.

Authors:
Thanh Sang Vo

J Food Biochem 2020 Jun 25:e13335. Epub 2020 Jun 25.

Faculty of Natural Sciences, Thu Dau Mot University, Thu Dau Mot City, Vietnam.

Mast cells and basophils are important contributors for development of allergic reactions. The activation of these cells via cross-linking of IgE bound to FcεRI by allergen causes the generation of allergic mediators and the reaction of immediate hypersensitivity. Obviously, FcεRI is considered as a key trigger of acute allergic responses. Read More

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http://dx.doi.org/10.1111/jfbc.13335DOI Listing

Ocular allergy test and biomarkers on the ocular surface: Clinical test for evaluating the ocular surface condition in allergic conjunctival diseases.

Authors:
Jun Shoji

Allergol Int 2020 Jun 17. Epub 2020 Jun 17.

Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, 30-1 Ohyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan. Electronic address:

Allergic conjunctival diseases (ACDs) are inflammatory diseases of the conjunctiva and cornea caused predominantly by the IgE-mediated immediate hypersensitivity response. Allergic conjunctival diseases include allergic conjunctivitis, vernal keratoconjunctivitis (VKC), atopic keratoconjunctivitis (AKC), and giant papillary conjunctivitis. In clinical practice of ACDs, an ocular allergy test using biomarker measurement is a crucial examination technique for diagnosing, evaluating severity, and determining the efficacy of medical treatment. Read More

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http://dx.doi.org/10.1016/j.alit.2020.05.003DOI Listing

Epoetin-alfa induced pruritic maculopapular eruption: Case report and literature review.

Asian Pac J Allergy Immunol 2020 Jun 21. Epub 2020 Jun 21.

Division of Allergy Immunology and Rheumatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Erythropoiesis-stimulating agents (ESA) are commonly used in clinical practice to improve anaemia. Despite a number of patients successfully treated without adverse events, the complications have been previously reported.

Objective: To report and review the characteristics and management of ESA hypersensitivities. Read More

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http://dx.doi.org/10.12932/AP-040719-0592DOI Listing

[Severe noncardiogenic pulmonary edema due to permeability disorder after i.v. administration of CT contrast medium with subsequent venovenous extracorporeal membrane oxygenation].

Anaesthesist 2020 Jun 16. Epub 2020 Jun 16.

Klinik für Anaesthesiologie, LMU Klinikum, Marchioninistr. 15, 81377, München, Deutschland.

Hypersensitivity reactions are one of the most feared side effects associated with the use of CT contrast agents. Bronchospasm and lung edema are known manifestations, whereby the latter occurs much less often. In anaphylaxis, numerous mechanisms can lead to cardiac failure with subsequent lung edema. Read More

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http://dx.doi.org/10.1007/s00101-020-00804-8DOI Listing

Alpha-gal syndrome: An emerging cause of food and drug allergy.

Clin Exp Allergy 2020 Jun 15. Epub 2020 Jun 15.

Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Bialystok, Poland.

Alpha-gal syndrome (AGS) describes a wide spectrum of hypersensitivity reactions mediated by specific IgE to the α-gal epitope (galactose-α-1,3-galactose) ubiquitously expressed on glycolipids/glycoproteins of most mammals. This fascinating new entity has completely changed the paradigms of allergy as allergic response is directed against an oligosaccharide and the reactions can be both immediate and delayed. They appear to be stimulated only by tick bites which induce production of α-gal specific IgE antibodies that lead to (at times fatal) hypersensitivity response. Read More

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http://dx.doi.org/10.1111/cea.13683DOI Listing

Immediate hypersensitivity reaction to ixekizumab in a patient with psoriasis.

J Eur Acad Dermatol Venereol 2020 Jun 13. Epub 2020 Jun 13.

Department of Dermatology, CH de Valence, Valence, France.

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http://dx.doi.org/10.1111/jdv.16748DOI Listing

Increased immediate early gene activation in the basolateral amygdala following persistent peripheral inflammation.

Neuroreport 2020 Jul;31(10):724-729

Laboratory of Neuroendocrinology and Behavior, Department of Biological Sciences.

Chronic pain results in a variety of neural adaptations, many of which are maladaptive and result in hypersensitivity to pain. In humans, this hypersensitivity can be debilitating and treatment options are limited. Fortunately, there are numerous animal models that mimic clinical populations and have the potential to aid in the evaluation of underlying mechanisms and ultimately the development of better treatments. Read More

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http://dx.doi.org/10.1097/WNR.0000000000001480DOI Listing

In Vitro Study on the Effect of a New Bioactive Desensitizer on Dentin Tubule Sealing and Bonding.

J Funct Biomater 2020 Jun 2;11(2). Epub 2020 Jun 2.

Department of Restorative Dentistry, University of Washington, Seattle, WA 98195, USA.

Bioactive mineral-based dentin desensitizers that can quickly and effectively seal dentinal tubules and promote dentin mineralization are desired. This in vitro study evaluated a novel nanohydroxyapatite-based desensitizer, Predicta (PBD, Parkell), and its effect on bond strength of dental adhesives. Human dentin discs (2-mm thick) were subjected to 0. Read More

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http://dx.doi.org/10.3390/jfb11020038DOI Listing

An immediate hypersensitivity reaction induced by PEGylated recombinant factor VIII.

Haemophilia 2020 Jun 4. Epub 2020 Jun 4.

Department of Pediatrics, Jichi Medical University School of Medicine, Tochigi, Japan.

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http://dx.doi.org/10.1111/hae.14048DOI Listing

An acid-hydrolyzed wheat protein activates the inflammatory and NF-κB pathways leading to long TSLP transcription in human keratinocytes.

J Toxicol Sci 2020 ;45(6):327-337

Department of Material Science and Engineering, Faculty of Engineering, Yokohama National University.

Hydrolyzed wheat proteins (HWPs) contained in cosmetics have occasionally caused immediate-type hypersensitivity following repeated skin exposure. Although the Cosmetic Ingredient Review Expert Panel concluded that < 3,500 Da HWP is safe for use in cosmetics, it remains biologically unknown how allergenic HWPs evoke immediate-type allergy percutaneously. Keratinocyte-derived thymic stromal lymphopoietin (TSLP) induces type 2 immune responses, which play an essential role in the pathogenesis of immediate-type allergy. Read More

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http://dx.doi.org/10.2131/jts.45.327DOI Listing
January 2020

The use of in vivo and in vitro tests in children with beta lactam allergy.

Allergol Immunopathol (Madr) 2020 May 27. Epub 2020 May 27.

Balıkesir University Medical, Faculty Hospital, Department of Pediatrics, Division of Immunology and Allergy Clinic, Balıkesir, Turkey; Department of Pediatrics, Division of Immunology and Allergy Clinic, Izmir, Turkey.

Background: Drug allergies are reactions within the context of drug hypersensitivity reactions, which are caused by immunological mechanisms due to a previously sensitising drug. Beta-lactam antibiotics (BLA) are the leading agents causing drug hypersensitivity reactions in children. The aim of this study is to evaluate the diagnostic importance of in vivo and in vitro diagnostic tests in children with suspected immediate-type BLA hypersensitivity and to investigate the frequency of their use for the final diagnosis. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.013DOI Listing

Adding a second skin prick test reading and modifying the Cut-off for Beta-lactam-specific IgE enhances the sensitivity in the routine diagnostic work-up for immediate Beta-lactam-hypersensitivity.

Contact Dermatitis 2020 May 28. Epub 2020 May 28.

Allergy-clinic of the Department of Dermatology, University Hospital of Erlangen, Germany.

Background: Beta-lactam (BL)-antibiotics are the most frequent reason for drug-induced hypersensitivity reactions. Since they are more efficient, less toxic and less costly than other antibiotics, confirmation or exclusion of BL-allergy is worthwhile. However, allergy tests for drug-allergies are often false-negative. Read More

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http://dx.doi.org/10.1111/cod.13622DOI Listing

Adverse Events to the Gadolinium-based Contrast Agent Gadoxetic Acid: Systematic Review and Meta-Analysis.

Radiology 2020 May 26:200073. Epub 2020 May 26.

From the Department of Medical Imaging, The Ottawa Hospital, 1053 Carling Ave, Room C159, Ottawa, ON, Canada K1Y 4E9 (N.S., D.W.); Department of Diagnostic Imaging, Juravinski Cancer Centre, Hamilton, Canada (C.B.v.d.P.); Clinical Research Unit, Children's Hospital of Eastern Ontario, Ottawa, Canada (A.K.T.); Department of Radiology, Sunnybrook Health Sciences Centre, Toronto, Canada (P.J.M.); Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (S.W.); and Department of Radiology, University of Michigan Medical Center, Ann Arbor, Mich (M.S.D.).

Background Gadoxetic acid is classified by the American College of Radiology as a group III gadolinium-based contrast agent (GBCA), which indicates that there are limited data regarding nephrogenic systemic fibrosis (NSF) risk, but there are few if any unconfounded cases of NSF. Purpose To perform a systematic review and meta-analysis of gadoxetic acid adverse events, including immediate hypersensitivity reactions, NSF, and intracranial gadolinium retention. Materials and Methods Original research studies, case series, and case reports that reported adverse events in patients undergoing gadoxetic acid-enhanced MRI were searched in MEDLINE (1946-2019), Embase (1947-2019), CENTRAL (March 2019), and Scopus (1946-2019). Read More

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http://dx.doi.org/10.1148/radiol.2020200073DOI Listing

Provider Variability in the Management Patterns of Increased Nonacid Reflux.

Dig Dis Sci 2020 May 23. Epub 2020 May 23.

Division of Gastroenterology, University of Michigan Hospitals-Michigan Medicine, 3912 Taubman Center, 1500 E Medical Center Dr., SPC 5362, Ann Arbor, MI, 48109, USA.

Introduction: Increased nonacid reflux is diagnosed in a subgroup of patients with gastroesophageal reflux disease who often present with reflux symptoms refractory to proton-pump inhibitor therapy. Despite the prevalence of this condition, the management approach for patients with increased nonacid reflux can often be varied and unclear.

Aims: Our primary aim was to investigate physician management patterns for patients who had received a diagnosis of increased nonacid reflux on impedance-pH studies. Read More

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http://dx.doi.org/10.1007/s10620-020-06348-6DOI Listing

Hypersensitivity Reactions to Biologicals: from Bench to Bedside.

Curr Treat Options Allergy 2020 18;7(1):71-83. Epub 2020 Jan 18.

Department of Pediatric Allergy, Hacettepe University School of Medicine, 06100 Ankara, Turkey.

Purpose Of Review: Biologic agents are new treatment options for chronic inflammatory diseases and cancers. As a result of their unique mechanism of action, they are more effective and less toxic treatment option and their clinical usage is increasing. While they are more commonly used, various adverse effects have been observed including life-threatening ones including anaphylaxis. Read More

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http://dx.doi.org/10.1007/s40521-020-00242-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222858PMC
January 2020

Allergenicity of Deamidated and/or Peptide-Bond-Hydrolyzed Wheat Gliadin by Transdermal Administration.

Foods 2020 May 15;9(5). Epub 2020 May 15.

Department of Chemistry and Life Science, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan.

Hydrochloric acid (HCl)-treated wheat protein (HWP) is widely used in various products, including foods, cosmetics and shampoos. Recently, immediate hypersensitivity towards facial soap containing HWP has been reported. HCl treatment of protein causes hydrolysis not only of main-chain amide bonds (peptide-bond hydrolysis) but also of side-chain ones (deamidation). Read More

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http://dx.doi.org/10.3390/foods9050635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278741PMC

Direct drug provocation test for the diagnosis of self-reported, mild and immediate drug hypersensitivity reaction in children and adolescents: our real-life experience.

Minerva Pediatr 2020 May 15. Epub 2020 May 15.

Allergy Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Messina, Italy.

Background: Approximately 10% of the parents report suspected drug hypersensitivity reactions to at least one drug in their children, but most of these reactions are not confirmed after an adequate diagnostic work-up. The diagnosis of drugs hypersensitivity is frequently laborious and based on anamnesis, skin tests, serum-specific IgE research and drug provocation test. Nevertheless, drug provocation test is necessary to confirm or definitively exclude the diagnosis of allergy. Read More

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http://dx.doi.org/10.23736/S0026-4946.20.05710-2DOI Listing

Deep slow nasal respiration with tight lip closure for immediate attenuation of severe tics.

J Clin Neurosci 2020 Jul 13;77:67-74. Epub 2020 May 13.

Anatomy and Physiology Laboratory, Department of Health and Nutrition, Osaka Shoin Women's University, Higashiosaka, Japan.

Background: Severe intractable tics, which are associated with Tourette syndrome and chronic tic disorder (TS/CTD), severely affect the quality of life. Common less-invasive treatments are often unable to attenuate tics with deep brain stimulation currently being the only effective treatment. We aimed to assess the anti-tic effect of deep slow nasal respiration with tight lip closure using patients with TS/CTD. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.05.037DOI Listing

Teicoplanin-induced immediate and delayed hypersensitivity reactions.

Ann Allergy Asthma Immunol 2020 May 13. Epub 2020 May 13.

Department of Allergy, Cambridge University Teaching Hospitals NHS Foundation Trust, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/j.anai.2020.05.006DOI Listing

Promising Use Of The New Biologics In The Management Of Drug-Induced Hypersensitivity Reactions: Preliminary Approaches.

Endocr Metab Immune Disord Drug Targets 2020 May 15. Epub 2020 May 15.

Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari. Italy.

Biologics are an innovative class of drugs that can selectively influence immunological responses at a cellular level. Although their use is usually restricted to some specific diseases such as autoimmune pathologies and tumors, their "off-label" administration has increased widely in the last years. Drug treatment may induce hypersensitivity reactions which currently lack any gold standard therapy but may be a future field of application for biologics. Read More

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http://dx.doi.org/10.2174/1871530320666200515113736DOI Listing

Hypersensitivity Reactions to Monoclonal Antibodies in Children.

Medicina (Kaunas) 2020 May 12;56(5). Epub 2020 May 12.

Clinica Pediatrica, Dipartimento Medicina e Chirurgia, Università di Parma, 43126 Parma, Italy.

Biologic drugs are widely used in pediatric medicine. Monoclonal antibodies (mAbs) in particular are a therapeutic option for rheumatic, autoinflammatory and oncologic diseases. Adverse drug reactions and hypersensitivity reactions (HSR) to mAbs may occur in children. Read More

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http://dx.doi.org/10.3390/medicina56050232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279169PMC

Pollen-food allergy syndrome in children.

Authors:
You Hoon Jeon

Clin Exp Pediatr 2020 May 14. Epub 2020 May 14.

Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.

Pollen-food allergy syndrome (PFAS) is an immunoglobulin E-mediated immediate allergic reaction caused by cross-reactivity between pollen and the antigens of foods-such as fruits, vegetables, or nuts-in patients with pollen allergy. A 42.7% prevalence of PFAS in Korean pediatric patients with pollinosis was recently reported. Read More

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http://dx.doi.org/10.3345/cep.2019.00780DOI Listing

Low-power laser and potassium oxalate gel in the treatment of cervical dentin hypersensitivity-a randomized clinical trial.

Clin Oral Investig 2020 May 7. Epub 2020 May 7.

Department of Dentistry and Pos Graduate Program in Dentistry, Health Sciences School, University of Brasília, Campus Asa Norte, Brasilia, Federal District, 70904-970, Brazil.

Objective: To evaluate the effectiveness of different protocols for the treatment of cervical dentin hypersensitivity (CDH) in non-carious cervical lesions (NCCLs).

Materials And Methods: The CONSORT checklist was used to design this study. The sample with n = 74 participants (389 NCCLs) was randomly allocated into three groups: G1, potassium oxalate (Oxa-Gel BF); G2, GaAlAs (gallium-aluminum-arsenate) low-power laser (100 mW, 808nn, 60 J/cm); and G3, potassium oxalate (Oxa-Gel BF) associated with the GaAlAs low-power laser. Read More

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http://dx.doi.org/10.1007/s00784-020-03311-7DOI Listing

Clinical Characterization and Diagnostic Approaches for Patients Reporting Hypersensitivity Reactions to Quinolones.

J Allergy Clin Immunol Pract 2020 May 4. Epub 2020 May 4.

Allergy Research Group, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Civil, Málaga, Spain; Allergy Unit, Hospital Regional Universitario de Málaga, Hospital Civil, Málaga, Spain; Nanostructures for Diagnosing and Treatment of Allergic Diseases Laboratory, Andalusian Center for Nanomedicine and Biotechnology-BIONAND, Parque Tecnológico de Andalucía, Málaga, Spain; Departamento de Medicina, Universidad de Málaga, Facultad de Medicina, Málaga, Spain.

Background: Quinolones are the second most frequent cause of hypersensitivity reactions (HSRs) to antibiotics. A marked increase in the number of patients with HSRs to quinolones has been detected.

Objective: To describe the clinical characteristics of patients with HSRs to quinolones and present methods for their diagnosis. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.04.051DOI Listing

Lower dose and lower injection speed of iodinated contrast media: a new strategy to reduce the incidence rate of immediate hypersensitivity reactions.

Authors:
Ingrid B Böhm

Quant Imaging Med Surg 2020 Apr;10(4):883-885

Department of Diagnostic, Interventional, and Pediatric Radiology, Inselspital, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.21037/qims.2020.03.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188615PMC

Rapid desensitization to antineoplastic drugs in an outpatient immunoallergology clinic: Outcomes and risk factors.

Ann Allergy Asthma Immunol 2020 Apr 27. Epub 2020 Apr 27.

Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: Hypersensitivity reactions to antineoplastic agents may lead to discontinuation of first-line treatments. Rapid drug desensitization (RDD) allows for a safe reintroduction in patients who are allergic to them.

Objective: To evaluate the safety and efficacy of the Brigham and Women's Hospital's 12-step RDD in a Portuguese patient population with cancer and to identify markers associated with breakthrough reactions (BTRs) to platins. Read More

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http://dx.doi.org/10.1016/j.anai.2020.04.017DOI Listing

Understanding buckwheat allergies for the management of allergic reactions in humans and animals.

Breed Sci 2020 Mar 4;70(1):85-92. Epub 2020 Feb 4.

Division of Food Safety, Faculty of Veterinary Medicine, Okayama University of Sciences, 1-3 Ikoinooka, Imabari, Ehime 794-8555, Japan.

Buckwheat allergy is an immediate hypersensitivity reaction that includes anaphylaxis mediated by specific IgE antibodies. Several IgE-binding proteins in common buckwheat have been reported to be possible clinically relevant buckwheat allergens. Although common buckwheat is popularly consumed in Asia, buckwheat allergy is becoming a serious problem not only in Asia but also in Europe. Read More

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http://dx.doi.org/10.1270/jsbbs.19051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180145PMC

Mast Cells in Inflammation and Disease: Recent Progress and Ongoing Concerns.

Annu Rev Immunol 2020 Apr;38:49-77

Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA; email:

Mast cells have existed long before the development of adaptive immunity, although they have been given different names. Thus, in the marine urochordate , they have been designated as test cells. However, based on their morphological characteristics (including prominent cytoplasmic granules) and mediator content (including heparin, histamine, and neutral proteases), test cells are thought to represent members of the lineage known in vertebrates as mast cells. Read More

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http://dx.doi.org/10.1146/annurev-immunol-071719-094903DOI Listing

Immediate Hypersensitivity Reactions Caused by Drug Excipients: A Literature Review.

J Investig Allergol Clin Immunol 2020 Apr;30(2):86-100

Department of Allergy, La Paz University Hospital, IdiPAZ, Madrid, Spain.

The European Medicines Agency defines excipients as the constituents of a pharmaceutical form apart from the active substance. Immediate hypersensitivity reactions (IHRs) caused by excipients contained in the formulation of medications have been described. However, there are no data on the prevalence of IHRs due to drug excipients. Read More

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http://dx.doi.org/10.18176/jiaci.0476DOI Listing

Effect of brimonidine tartrate on basophil activation in glaucoma patients.

Int J Ophthalmol 2020 18;13(3):509-512. Epub 2020 Mar 18.

Department of Allergy and Immunology, Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel.

Aim: To evaluate the mechanism of which brimonidine tartrate 0.15% causes clinical hypersensitivity.

Methods: A prospective case-control study comparing 8 glaucoma patients with clinical hypersensitivity to brimonidine to a control group consisting 13 healthy volunteers. Read More

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http://dx.doi.org/10.18240/ijo.2020.03.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154197PMC

Delayed positive skin tests in patients with immediate hypersensitivity reactions to beta-lactams.

J Allergy Clin Immunol Pract 2020 Jul - Aug;8(7):2431-2433. Epub 2020 Apr 15.

Department of Pulmonology, Division of Allergy, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, University of Montpellier, Montpellier, France; UMR-S 1136 INSERM-Sorbonne Université, Equipe EPAR - IPLESP, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2020.03.039DOI Listing

Animal models for analysis of hypersensitivity reactions to Shuanghuanglian injection.

Mol Immunol 2020 Apr 14;122:62-68. Epub 2020 Apr 14.

Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China. Electronic address:

Among a variety of traditional Chinese medicines, Shuanghuanglian injection (SHLI), has the highest incidence of injection-induced immediate hypersensitivity reactions (IHRs). However, the precise mechanisms of SHLI-induced IHRs remain to be understood. In the present study, we characteriszed IHRs as induced by SHLI by recording changes in physiological and hemodynamic indicators following intravenous injections of SHLI in rats and dogs. Read More

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http://dx.doi.org/10.1016/j.molimm.2020.03.014DOI Listing

Drug hypersensitivity in the fast lane: What clinicians should know about phenotypes, endotypes, and biomarkers.

Ann Allergy Asthma Immunol 2020 06 15;124(6):566-572. Epub 2020 Apr 15.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts.

Objective: To review novel concepts in drug hypersensitivity and the management of immediate hypersensitivity reactions.

Data Sources: English language literature on MEDLINE and Embase surrounding drug hypersensitivity and desensitization.

Study Selections: References were selected based on relevance, date of publication, and originality. Read More

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http://dx.doi.org/10.1016/j.anai.2020.04.005DOI Listing

Mixed drug reaction to amiodarone characterized by sequential immediate, immune complex, and delayed hypersensitivity.

Ann Allergy Asthma Immunol 2020 Jul 10;125(1):102-103. Epub 2020 Apr 10.

Immunorheumatology Laboratory, New South Wales Health Pathology, Royal North Shore Hospital, Sydney, Australia.

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http://dx.doi.org/10.1016/j.anai.2020.03.032DOI Listing

Fennel as a cause of immediate hypersensitivity to toothpaste.

Ann Allergy Asthma Immunol 2020 Jul 4;125(1):99-100. Epub 2020 Apr 4.

Department of Paediatric Allergy and Immunology, Royal Manchester Children's Hospital, Manchester, Lancashire, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2020.03.030DOI Listing

Asthma, allergic sensitization and lung function in sickle cell disease.

Allergol Immunopathol (Madr) 2020 Apr 2. Epub 2020 Apr 2.

Division of Hematology, Department of Pediatrics, Federal University of São Paulo (UNIFESP), Brazil.

Background: Pulmonary disease is a frequent acute and chronic manifestation in sickle cell disease (SCD), presenting high morbidity and mortality.

Objectives: To identify the prevalence and association of asthma, allergic sensitization and altered pulmonary function in patients with SCD (SS and Sβ).

Methods: A single-center, cross-sectional study was conducted, in which 70 patients with SCD and 44 controls, aged six to 18 years, responded to the questionnaire of the International Study of Asthma and Allergies in Childhood (ISAAC), complemented with an anamnesis regarding the associated clinical outcomes. Read More

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http://dx.doi.org/10.1016/j.aller.2019.12.012DOI Listing

Characterization of amoxicillin and clavulanic acid specific T-cell clones from patients with immediate drug hypersensitivity.

Allergy 2020 Apr 4. Epub 2020 Apr 4.

Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK.

Background: Betalactam (BL) antibiotics are the most common cause of drug hypersensitivity. Amoxicillin (AX), which is often prescribed alongside clavulanic acid (Clav), is the most common elicitor. The aim of this study was to determine whether AX and Clav-responsive T-cells are detectable in patients with immediate hypersensitivity to AX-Clav, to assess whether these T-cells display the same specificity as that detected in skin and provocation testing, and to explore T-cell activation pathways. Read More

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http://dx.doi.org/10.1111/all.14298DOI Listing
April 2020
6.028 Impact Factor

Subsequent MRI of pediatric patients after an adverse reaction to Gadolinium-based contrast agents.

PLoS One 2020 3;15(4):e0230781. Epub 2020 Apr 3.

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

Background: Gadolinium-based contrast agent (GBCA)-enhanced magnetic resonance imaging (MRI) scans often must be used repeatedly in pediatric oncologic patients. Although GBCAs are usually well tolerated, severe and life-threatening allergic reactions might occur, which can result in overly cautions adherence to special precautions in patients.

Purpose: To evaluate the management of the reported GBCA-associated adverse reactions in subsequent contrast-enhanced MRIs in pediatric patients, distinguishing non-allergic and allergic reactions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230781PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122741PMC

Immunogenicity and safety of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT) in healthy toddlers: a Phase II randomized study.

Hum Vaccin Immunother 2020 Jun 1;16(6):1306-1312. Epub 2020 Apr 1.

Global Clinical Sciences, Sanofi Pasteur , Swiftwater, PA, USA.

Neisseria Meningitidis: can lead to invasive meningococcal disease to which young children are particularly vulnerable. We assessed the immunogenicity and safety of Sanofi Pasteur's investigational quadrivalent (serogroups A, C, Y, and W) meningococcal tetanus-toxoid conjugate vaccine, MenACYW-TT, as a single dose, in healthy meningococcal vaccine-naïve toddlers versus a licensed conjugate vaccine MCV4-TT (NCT03205358). In this Phase II study conducted in Finland, 188 toddlers aged 12-24 months were randomized 1:1 to MenACYW-TT or MCV4-TT. Read More

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http://dx.doi.org/10.1080/21645515.2020.1733869DOI Listing

Near-fatal anaphylaxis with Kounis syndrome caused by bite: a case report.

Clin Mol Allergy 2020 18;18. Epub 2020 Mar 18.

Cardiac/Pulmonary Rehabilitation Unit, ASST Pini-CTO, Milan, Italy.

Background: The pigeon tick is a temporary parasite of pigeons. It bites during night hours and lies briefly on its prey, as long as it takes the blood meal. When pigeons are not accessible, ticks look for other hosts, invading nearby flats and biting humans. Read More

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http://dx.doi.org/10.1186/s12948-020-00121-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079397PMC

[A CASE OF EOSINOPHILIC GASTROENTERITIS FOUND BY PICA DURING ORAL IMMUNOTHERAPY].

Arerugi 2020 ;69(2):123-128

Allergy Center, National Center for Child Health and Development.

Eosinophilic esophagitis has been reported as a complication of oral immunotherapy (OIT), but there are only a few reports of eosinophilic gastroenteritis (EGE) occurring after OIT. EGE causes eosinophil infiltration into the gastrointestinal (GI) tract and is characterized by various digestive symptoms. We report the case of a 6-year-old boy with EGE. Read More

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http://dx.doi.org/10.15036/arerugi.69.123DOI Listing

Physiological responses to cisplatin using a mouse hypersensitivity model.

Inhal Toxicol 2020 02 18;32(2):68-78. Epub 2020 Mar 18.

Center for Public Health & Environmental Assessment (CPHEA), US - Environmental Protection Agency, Durham, NC, USA.

: The physiological mechanisms underlying the development of respiratory hypersensitivity to cisplatin (CDDP) are not well-understood. It has been suggested that these reactions are likely the result of type I hypersensitivity, but other explanations are plausible and the potential for CDDP to induce type I hypersensitivity responses has not been directly evaluated in an animal model. : To investigate CDDP hypersensitivity, mice were topically sensitized through application of CDDP before being challenged by oropharyngeal aspiration (OPA) with CDDP. Read More

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http://dx.doi.org/10.1080/08958378.2020.1737762DOI Listing
February 2020

Corticosteroid-induced drug reaction with eosinophilia and systematic symptoms successfully treated with a tumor necrosis factor alpha inhibitor.

Asian Pac J Allergy Immunol 2020 Mar 8. Epub 2020 Mar 8.

Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.

Background: Despite recent advances in the treatment of drug reaction with eosinophilia and systemic symptoms (DRESS), the mainstay of treatment involves discontinuing the culprit drugs and administering topical or systemic corticosteroid.

Objective: The clinical use of a tumor necrosis factor (TNF)-alpha inhibitor was rarely explored in treatment of DRESS.

Methods: We present a case of corticosteroid-induced DRESS that was successfully treated with a TNF-alpha inhibitor without sequalae. Read More

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http://dx.doi.org/10.12932/AP-210819-0628DOI Listing