18,165 results match your criteria Hypersensitivity Reactions Immediate


Low cross-reactivity between cisplatin and other platinum salts.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Dermatology Department, Dijon University Hospital, Dijon, France.

Background: Hypersensitivity reactions to platinum salts (PS) (cisplatin (CI), carboplatin (CA) and oxaliplatin (OX)) can be severe and their incidence is increasing due to their widespread use in cancer treatment.

Objective: To determine the rate of cross-reactivity between platinum salts and whether CI can be administered without prior allergy testing in patients with a history of CA or OX hypersensitivity.

Methods: From September 2002 to April 2016, patients with suspected immediate PS hypersensitivity were tested and cross-reactivity between the three PS was evaluated. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.057DOI Listing
February 2019

Health care worker sensitivity to chlorhexidine-based hand hygiene solutions: A cross-sectional survey.

Am J Infect Control 2019 Feb 11. Epub 2019 Feb 11.

School of Nursing and Midwifery, Deakin University, Geelong, Victoria, Australia; Centre for Quality and Patient Safety Research-Monash Health Partnership, School of Nursing and Midwifery, Deakin University, Burwood, Victoria, Australia. Electronic address:

Background: Health service hand hygiene programs have seen widespread use of chlorhexidine solutions. Reports of both immediate and delayed hypersensitivity to chlorhexidine are increasing among health care workers. This study examined the prevalence of self-reported symptoms of sensitivity to chlorhexidine solutions among health care workers. Read More

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http://dx.doi.org/10.1016/j.ajic.2019.01.006DOI Listing
February 2019

Acute generalized exanthematous pustulosis induced by iomeprol with cross-reactivity to other iodinated contrast agents and mild reaction after rechallenge with iopromide and oral corticosteroid premedication.

Contact Dermatitis 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, University of Tours, France.

Immediate hypersensitivity reactions to iodinated contrast media (ICM) are rare and occur within 1 hour after infusion, but also up to 7 days later. This article is protected by copyright. All rights reserved. Read More

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http://dx.doi.org/10.1111/cod.13242DOI Listing
February 2019
1 Read

Immediate hypersensitivity reaction to human serum albumin in a child undergoing plasmapheresis.

Transfusion 2019 Feb 13. Epub 2019 Feb 13.

Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Background: Human serum albumin (HSA) is a commonly used colloid for volume expansion and albumin replacement and during plasmapheresis. Colloids are an uncommon cause of anaphylaxis, and cases of hypersensitivity reactions to HSA are extremely rare.

Case Report: A 10-year-old boy with chronic inflammatory demyelinating polyneuropathy was treated with plasmapheresis, with albumin as the replacement fluid. Read More

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http://dx.doi.org/10.1111/trf.15194DOI Listing
February 2019

Skin tests are important in children with β-lactam hypersensitivity, but may be reduced in number.

Pediatr Allergy Immunol 2019 Feb 7. Epub 2019 Feb 7.

Allergy Unit, Département de Pneumologie et Addictologie, Hôpital Arnaud de Villeneuve, CHU de Montpellier, Univ Montpellier, France.

There is no perfect agreement on how to perform an allergy work-up in suspected beta-lactam (BL) allergic children, since skin test (ST)-induced pain is often a limitation. The aim of the study was to assess the possibility of reducing the number of ST in children when performing a complete allergy work-up for BL hypersensitivity reactions. A retrospective analysis of all patients referring to the Allergy Unit of the University Hospital of Montpellier (France) with positive responses in immediate- and non-immediate-reading ST to a BL over a 16-years period was performed, to determine the positive predictive value (PPV) of ST. Read More

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http://dx.doi.org/10.1111/pai.13041DOI Listing
February 2019
1 Read

Diagnosis and management of drug-induced anaphylaxis in children: an EAACI position paper.

Pediatr Allergy Immunol 2019 Feb 7. Epub 2019 Feb 7.

Geneva University Hospitals, Department of child and adolescent, Pediatric Allergy Unit, Geneva, Switzerland.

Drug hypersensitivity reactions (DHR) constitute a major and common public health problem, particularly in children. One of the most severe manifestations of DHR is anaphylaxis, which might be associated with a life-threatening risk. During those past decades, anaphylaxis has received particularly a lot of attention and international consensus guidelines have been recently published. Read More

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http://dx.doi.org/10.1111/pai.13034DOI Listing
February 2019
1 Read

Allergic Reactions Captured by Voluntary Reporting.

J Patient Saf 2019 Jan 31. Epub 2019 Jan 31.

Edward P. Lawrence Center for Quality and Safety, Massachusetts General Hospital and the Massachusetts General Professional Organization.

Background: The epidemiology of hospital adverse reactions (ARs), particularly allergic reactions, or hypersensitivity reactions (HSRs), is poorly defined. To determine priorities for allergy safety in healthcare, we identified and described safety reports of allergic reactions.

Methods: We searched the safety report database of a large academic medical center from April 2006 to March 2016 using 101 complete, truncated, and/or misspelled key words related to allergic symptoms, treatments, and culprits (e. Read More

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http://dx.doi.org/10.1097/PTS.0000000000000568DOI Listing
January 2019
2 Reads

Efficacy of 8% arginine on dentin hypersensitivity: A multicenter clinical trial in 273 patients over 24 weeks.

J Dent 2019 Jan 30. Epub 2019 Jan 30.

Department of Operative Dentistry and Periodontology, School of Dental Medicine, Martin-Luther-University, Harz 42a, 06108, Halle, Germany. Electronic address:

Objectives: To assess the efficacy of 8% arginine containing prophylaxis products over 24 weeks in subjects with dentin hypersensitivity (DH).

Methods: 297 patients with established DH (Schiff score 2, 3) in three European study centers were randomly assigned to either 8% arginine and calcium carbonate in-office prophylaxis paste and the respective toothpaste (test group) or fluoride-free prophylaxis paste and sodium monoflourophosphate toothpaste as a negative control group. Air blast (Schiff Score) and tactile (Visual Analog Scale) sensitivity scores were assessed at baseline (BL_0), after single application of the prophylaxis paste (BL_1) and after 4, 8, and 24 weeks of continuous at-home use of the toothpaste. Read More

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http://dx.doi.org/10.1016/j.jdent.2019.01.002DOI Listing
January 2019
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Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate.

Diabetologia 2019 Jan 31. Epub 2019 Jan 31.

Diabetes Research Institute and Cell Transplant Center, University of Miami Miller School of Medicine, 1450 NW 10th Ave, Miami, FL, 33136, USA.

Aims/hypothesis: Patients with autoimmune type 1 diabetes transplanted with pancreatic islets to their liver experience significant improvement in quality of life through better control of blood sugar and enhanced awareness of hypoglycaemia. However, long-term survival and efficacy of the intrahepatic islet transplant are limited owing to liver-specific complications, such as immediate blood-mediated immune reaction, hypoxia, a highly enzymatic and inflammatory environment and locally elevated levels of drugs including immunosuppressive agents, all of which are injurious to islets. This has spurred a search for new islet transplant sites and for innovative ways to achieve long-term graft survival and efficacy without life-long systemic immunosuppression and its complications. Read More

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http://dx.doi.org/10.1007/s00125-019-4814-4DOI Listing
January 2019
1 Read
6.671 Impact Factor

The clinical toxicology of sodium hypochlorite.

Clin Toxicol (Phila) 2019 Jan 28:1-9. Epub 2019 Jan 28.

a National Poisons Centre , University of Otago , Dunedin , New Zealand.

Introduction: Sodium hypochlorite is used as a bleaching and disinfecting agent and is commonly found in household bleach.

Objective: The objective is to review critically the epidemiology, mechanisms of toxicity, clinical features, diagnosis, and management of hypochlorite poisoning.

Methods: PubMed was searched from January 1950 to June 2018 using the terms "Hypochlorite", "Sodium Hypochlorite", "Sodium Oxychloride", "Hypochlorous Acid", "Bleach", "Chlorine Bleach", in combination with the keywords "poisoning", "poison", "toxicity", "ingestion", "adverse effects", "overdose", and "intoxication". Read More

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http://dx.doi.org/10.1080/15563650.2018.1543889DOI Listing
January 2019
1 Read

New IgE Immediate Hypersensitivity Reactions Upon Reintroduction of Food Restricted for Treatment of Eosinophilic Esophagitis.

Ann Allergy Asthma Immunol 2019 Jan 23. Epub 2019 Jan 23.

Department of Gastroenterology, University of North Carolina School of Medicine, Chapel Hill, NC.

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http://dx.doi.org/10.1016/j.anai.2019.01.010DOI Listing
January 2019
1 Read

Vaccine Allergy? Skin testing and challenge at a tertiary pediatric hospital in Melbourne, Australia.

J Allergy Clin Immunol Pract 2019 Jan 22. Epub 2019 Jan 22.

Department of Allergy & Immunology, Royal Children's Hospital, Melbourne, Australia; Food Allergy Research Group and Melbourne Children's Trial Centre, Murdoch Children's Research Institute, Melbourne, Australia; Department of General Medicine, Royal Children's Hospital, Melbourne, Australia; Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.

Background: The rate of true vaccine allergy is unknown. Children with potential IgE-mediated Adverse Events Following Immunization (AEFI) should undergo allergy investigation that may include skin testing or challenge. Previous protocols tend to be highly conservative and often suggest invasive testing for all; a practice not evidence based, technically difficult and unpleasant in children. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.025DOI Listing
January 2019
6 Reads

Common causes of emergency department visits for anaphylaxis in Korean community hospitals: A cross-sectional study.

Medicine (Baltimore) 2019 Jan;98(4):e14114

Division of Allergy and Clinical Immunology, Kangwon National University School of Medicine, Chuncheon, Korea.

Anaphylaxis can cause death and requires immediate management. For prevention and education programs for anaphylaxis, it is important to be aware of the common triggering factors. We investigated the triggers of anaphylaxis in the emergency departments (EDs) of community hospitals in Korea. Read More

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http://dx.doi.org/10.1097/MD.0000000000014114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358383PMC
January 2019
5 Reads

The incidence of skin lesions in contrast media-induced chemical hypersensitivity.

Exp Ther Med 2019 Feb 5;17(2):1113-1124. Epub 2018 Dec 5.

Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

Contrast agents are used in radiology to increase the sensibility and specificity of radiological techniques. Some of these compounds have side effects that include organ toxicity (with kidney being the most affected organ) and hypersensitivity reactions. We performed multiple PubMed searches from January, 2008 to January, 2018 for studies regarding adverse reactions to compounds used as contrast agents in imagistic techniques. Read More

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http://dx.doi.org/10.3892/etm.2018.7056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327547PMC
February 2019
1 Read

Incidence and risk factors of low-osmolar iodinated contrast media related immediate hypersensitivity reactions: A longitudinal study based on a real-time monitoring system.

J Investig Allergol Clin Immunol 2019 Jan 24. Epub 2019 Jan 24.

Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.

Background: We investigated the incidence of immediate hypersensitivity reaction (HSR) focusing on the types of low osmolar contrast media (LOCM) and accumulated exposures to LOCM.

Methods: This cohort study included all consecutive patients who underwent LOCM-enhanced computed tomography scan from 2012 through 2014. Five LOCMs (iobitridol, iohexol, iomeprol, iopamidol, and iopromide) were used. Read More

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http://dx.doi.org/10.18176/jiaci.0374DOI Listing
January 2019
1 Read

Eperisone-Induced Anaphylaxis: Pharmacovigilance Data and Results of Allergy Testing.

Allergy Asthma Immunol Res 2019 Mar;11(2):231-240

Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Eperisone is an oral muscle relaxant used in musculoskeletal disorders causing muscle spasm and pain. For more effective pain control, eperisone is usually prescribed together with nonsteroidal anti-inflammatory drugs (NSAIDs). As such, eperisone may have been overlooked as the cause of anaphylaxis compared with NSAIDs. Read More

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http://dx.doi.org/10.4168/aair.2019.11.2.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340802PMC
March 2019
2 Reads

A Novel Desensitization Protocol for Infliximab hypersensitivity in a 13-Year Old Patient with Pustular Psoriasis.

Curr Drug Saf 2019 Jan 18. Epub 2019 Jan 18.

Department of Pharmacology, Sri Ramachandra Institute of Higher Education and Research, Chennai. India.

Background: Drug hypersensitivity reactions to infliximab have been reported in pediatric patients. At times, these patients may need infliximab administration in spite of hypersensitivity. However, only a few reports of desensitization protocols are available in the literature in pediatric patients. Read More

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http://dx.doi.org/10.2174/1574886314666190119115632DOI Listing
January 2019
5 Reads

Cross-reactivity between halogenated platinum salts in an immediate-type respiratory hypersensitivity model.

Inhal Toxicol 2019 Jan 18:1-10. Epub 2019 Jan 18.

a Cardiopulmonary and Immunotoxicology Branch, Environmental Public Health Division, National Health, and Environmental Effects Laboratory (NHEERL) , U.S. Environmental Protection Agency , Research Triangle Park , NC , USA.

Halogenated platinum salts can trigger the development of occupational asthma. Until recently, laboratory research into the development and manifestation of platinum hypersensitivity responses were hindered by the lack of an animal model suitable for assessing the functional consequences of allergic sensitization. We employed a newly developed mouse model to assess the potential allergenicity of ammonium tetrachloroplatinate (ATCP), compare the relative potency of ATCP and another platinum salt, ammonium hexachloroplatinate (AHCP) and assess potential cross-reactivity. Read More

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http://dx.doi.org/10.1080/08958378.2018.1554015DOI Listing
January 2019
2 Reads

Series of 12 cases of wheat-dependent exercise-induced allergy in Aragon, Spain.

Rev Clin Esp 2019 Jan 13. Epub 2019 Jan 13.

Servicio de Alergología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, España.

Background And Objectives: The ω-5 gliadin (ω5G) is considered the main allergen in wheat-dependent exercise-induced anaphylaxis (WDEIA). These patients experience anaphylactic reactions after consuming wheat and performing physical exercise. The aim of our study was to describe the main characteristics of 12 patients with this diagnosis. Read More

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http://dx.doi.org/10.1016/j.rce.2018.11.004DOI Listing
January 2019
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Lidocaine as a Rare and Hidden Allergen in the Perioperative Setting: A Case Report.

A A Pract 2019 Jan 4. Epub 2019 Jan 4.

From the Danish Anaesthesia Allergy Centre, Allergy Clinic, Department of Dermatology and Allergology, Herlev and Gentofte Hospital, University of Copenhagen, Denmark.

Local anesthetics are used throughout the health care system. In the perioperative setting and in other settings of exposure to local anesthetics, true allergy is reported very rarely. We present an unusual case of immediate-type perioperative hypersensitivity to lidocaine with cross-reaction to mepivacaine, which was missed on initial investigation. Read More

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http://dx.doi.org/10.1213/XAA.0000000000000955DOI Listing
January 2019
1 Read

Analysis of the factors associated with diagnostic skin test positivity in immediate-type hypersensitivity reactions due to proton pump inhibitors.

Allergy 2019 Jan 11. Epub 2019 Jan 11.

Department of Chest Diseases, Division of Allergy and Immunology, Ankara University School of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.1111/all.13715DOI Listing
January 2019
3 Reads

[NSAID urticaria: Similar management to acute urticaria].

Rev Med Interne 2019 Mar 7;40(3):166-172. Epub 2019 Jan 7.

Service d'allergologie et immunologie clinique, hospices civils de Lyon, CHU Lyon-Sud, 69495 Pierre Bénite cedex, France; Université Lyon I, 69007 Lyon, France; - CIRI, Centre International de Recherche en Infectiologie, équipe 14, Univ Lyon, Inserm, U111, université Claude-Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007 Lyon, France. Electronic address:

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most common providers of immediate hypersensitivity reactions. Among these reactions, isolated acute urticaria is the most common clinical feature with a non-allergic origin. It is a pharmacological side effect resulting from the alteration of arachidonic acid metabolism induced by NSAIDs. Read More

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http://dx.doi.org/10.1016/j.revmed.2018.12.008DOI Listing
March 2019
1 Read

The Diagnosis of Ceftriaxone Hypersensitivity in a Paediatric Population.

Int Arch Allergy Immunol 2019 Jan 3:1-5. Epub 2019 Jan 3.

Department of Paediatrics, Allergy Unit, Anna Meyer Children's University Hospital, Florence, Italy.

Introduction: Penicillins and cephalosporins are the most frequent causes of hypersensitivity reactions (HRs) to drugs in children. Among cephalosporins for intravenous use, ceftriaxone (CT) is the most frequently prescribed in Italy. The aims of this study were to evaluate the diagnostic methods for CT hypersensitivity in a population of children with suspected HRs to this drug and their tolerance toward amoxi-cillin/clavulanic acid (AMX/CLV). Read More

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http://dx.doi.org/10.1159/000495302DOI Listing
January 2019
1 Read

[Severe and rare adverse reaction to hydrochlorothiazide].

Rev Alerg Mex 2018 Oct-Dec;65(4):442-445

Hospital Universitario Infanta Sofía, Departamento de Alergia, Madrid, España.

Background: The immune mechanism involved in the reaction to hydrochlorothiazide, which is widely used to control hypertension, is unknown. The short latency period between the take of the drug and the onset of symptoms suggests immediate hypersensitivity.

Case Report: 63-year-old woman with arterial hypertension who, on three occasions, experienced nausea, vomiting, general malaise, shivering, arthralgias, dysthermic sensation, back pain of mechanical characteristics and mild non-productive cough, as well as fever and chest tightness with increased dyspnea and desaturation of up to 88 %, after taking hydrochlorothiazide. Read More

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http://dx.doi.org/10.29262/ram.v65i4.363DOI Listing
January 2019
11 Reads

Immediate Hypersensitivity to Clindamycin: Rare, But Not Impossible.

J Allergy Clin Immunol Pract 2019 01;7(1):334-335

Department of Allergy, Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaip.2018.08.006DOI Listing
January 2019
2 Reads

Hepatic mast cell concentration directly correlates to stage of fibrosis in NASH.

Hum Pathol 2018 Dec 28. Epub 2018 Dec 28.

Pinnacle Clinical Research, San Antonio, TX.

Mast cells are present throughout the body in low numbers. We know their role in immediate hypersensitivity and the subsequent tissue damage due to release of cytokines, vasoactive amines, and lipid mediators when mast cells are activated. Recent research has found that there is an association between an increased concentration of mast cells in the liver and the severity of hepatic fibrosis in animal models. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.029DOI Listing
December 2018
2 Reads

Direct oral amoxicillin challenge without preliminary skin testing in adult patients with allergy and at low risk with reported penicillin allergy.

Allergy Asthma Proc 2019 Jan;40(1):57-61

Department of Internal Medicine, Emory University, Atlanta, Georgia.

Ten percent of hospitalized patients report penicillin allergy; however, recent studies indicate that ∼98% of these patients are not acutely hypersensitive. Unconfirmed penicillin allergy poses public health risks, and an evaluation of penicillin allergy labels is recommended to improve antibiotic stewardship. Although the most widely accepted protocol is penicillin skin testing, followed by oral amoxicillin challenge, time constraints and resources may preclude this. Read More

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http://dx.doi.org/10.2500/aap.2019.40.4184DOI Listing
January 2019
10 Reads

Controversies in Drug Allergy: Radiographic Contrast Media.

J Allergy Clin Immunol Pract 2019 Jan 17;7(1):61-65. Epub 2018 Dec 17.

Department of Dermatology and Allergy, University Hospital Würzburg, Würzburg, Germany.

The risk for developing immediate or delayed hypersensitivity reactions to radiocontrast media (RCM) interferes with the diagnosis and treatment of a number of patients requiring imaging diagnostic methods for many common diseases. A group of experts met in Orlando, Florida, in March 2018 to analyze the similarities and differences in the management of RCM reactions in different areas of the world. This paper presents a summary of the recommendations provided by this consensus group, highlighting controversial issues and unmet needs that require further research. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132198183046
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http://dx.doi.org/10.1016/j.jaip.2018.06.030DOI Listing
January 2019
7 Reads

Immediate and delayed contact hypersensitivity to thiocolchicoside.

Authors:
Giuseppe Mancuso

Acta Dermatovenerol Alp Pannonica Adriat 2018 Dec;27(4):203-205

Occupational Medicine Center of Ravenna, Lugo, Italy.

Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer. Read More

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December 2018
5 Reads

Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized.

J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.

Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.

Background: The most common immediate hypersensitivity to macrogols is associated with polyethylene glycol (PEG) 3350; however, the epidemiology, mechanisms, and cross-reactivity are poorly understood. Thousands of medications contain either PEGs or structurally similar polysorbates.

Objective: Our objective was to better understand the mechanism, cross-reactivity, and scope of PEG hypersensitivity. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.12.003DOI Listing
December 2018
10 Reads

Cefuroxime-induced anaphylaxis with prominent central nervous system manifestations: A case report.

J Int Med Res 2019 Feb 7;47(2):1010-1014. Epub 2018 Dec 7.

1 Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Wangfujing, Beijing, China.

Cefuroxime is a second-generation cephalosporin antibiotic that causes immediate hypersensitivity reactions, ranging from mild urticaria to severe anaphylactic shock. Anaphylactic reactions typically involve multiple systems, most notably, the skin and the respiratory and cardiovascular systems. Here, we report the unusual case of a patient who presented with oral cefuroxime-induced anaphylaxis with prominent neurologic manifestations. Read More

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http://dx.doi.org/10.1177/0300060518814118DOI Listing
February 2019
1 Read

SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children.

Ital J Pediatr 2018 Dec 7;44(1):147. Epub 2018 Dec 7.

Pediatric Unit, Infant Maternal Department, Azienda Sanitaria Provinciale Crotone, Crotone, Italy.

Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), that aims of ascertaining the causative role of an allergen and evaluating the tolerance to the suspected drug. Read More

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http://dx.doi.org/10.1186/s13052-018-0589-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286516PMC
December 2018
1 Read

Polymorphisms in the interleukin 4 receptor and interleukin 13 genes in immediate allergic reactions to beta-lactam antibiotics: A case-control study.

Asian Pac J Allergy Immunol 2018 Dec 9. Epub 2018 Dec 9.

Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke (QC), Canada.

Background: Immediate hypersensitivity reactions to beta-lactams are IgE-mediated and constitute the most common adverse reactions to antibiotics mediated by a specific immunologic mechanism.

Objective: We investigated the association between four functional polymorphisms of IL13 (R130Q variant) and IL4RA (I50V, S478P and Q551R variants) genes and susceptibility to immediate allergic reactions to beta-lactams in the Algerian population.

Methods: We determined these gene variants in 199 patients and 99 healthy controls from Algeria. Read More

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http://dx.doi.org/10.12932/AP-290318-0290DOI Listing
December 2018
4 Reads

Suspected Reaction with Cephalosporin May Be a Predictive Factor for β-Lactam Allergy in Children.

Int Arch Allergy Immunol 2018 Dec 5:1-7. Epub 2018 Dec 5.

Background: Most children diagnosed with β-lactam allergy based only on history are not truly allergic, and mislabeling leads to use of less effective and more costly alternative broader-spectrum antibiotics, significantly increasing drug resistance.

Objective: To determine the frequency and risk factors of confirmed allergy in patients with β-lactam allergy reported by parents or their doctors and evaluate cross-reactivity between β-lactams in children with confirmed allergy.

Method: Sixty-seven children with suspected β-lactam allergy were evaluated via history, sIgE measurements, skin tests, and drug provocation tests over a period of 5 years. Read More

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http://dx.doi.org/10.1159/000494506DOI Listing
December 2018
3 Reads

Drug Hypersensitivity Reactions Documented in Electronic Health Records within a Large Health System.

J Allergy Clin Immunol Pract 2018 Dec 1. Epub 2018 Dec 1.

Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, Mass; Department of Medicine, Harvard Medical School, Boston, Mass. Electronic address:

Background: Hypersensitivity reactions (HSRs) are immunologic responses to drugs. Identification of HSRs documented in the electronic health record (EHR) is important for patient safety.

Objective: To examine HSR epidemiology using longitudinal EHR data from a large United States health care system. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.11.023DOI Listing
December 2018
9 Reads

Enlarged Areas of Pain and Pressure Hypersensitivityby Spatially Distributed Intramuscular Injections ofLow-Dose Nerve Growth Factor.

J Pain 2018 Dec 1. Epub 2018 Dec 1.

Center for Neuroplasticity and Pain (CNAP), SMI. Electronic address:

Intramuscular injection of nerve growth factor (NGF) causes muscle hyperalgesia without immediate pain. This double-blinded, randomized study assessed pain and muscle hypersensitivity after a single-site bolus NGF injection (5 µg) compared with 5 spatially distributed, low-dose NGF injections (1 µg, 4 cm distance) into the tibialis anterior (TA) muscles in 20 healthy subjects. Injection pain was rated on a visual analog scale. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.11.005DOI Listing
December 2018
3 Reads

Repeat Contrast Medium Administration for Patients with Mild Immediate Hypersensitivity Reaction to Iodinated Contrast Media.

Authors:
Shoko Abe

Radiology 2019 Jan 4;290(1):270-271. Epub 2018 Dec 4.

Department of Radiology, St Marianna University School of Medicine, Kawasaki, Japan.

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http://pubs.rsna.org/doi/10.1148/radiol.2018182146
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http://dx.doi.org/10.1148/radiol.2018182146DOI Listing
January 2019
11 Reads

Immediate-Type Hypersensitivity Cross-Reactions to Proton Pump Inhibitors: A Descriptive Study of Data from the French National Pharmacovigilance Database.

Int Arch Allergy Immunol 2019 28;178(2):159-166. Epub 2018 Nov 28.

Clinical Pharmacology Department, Institute of Biology, CHU Nantes, Nantes, France.

Background: Proton pump inhibitors (PPIs) can trigger immediate-type hypersensitivity reactions (HSRs). Three main patterns of cross-reactivity have been identified: reactions to a single PPI, selective cross-reactions, and cross-reactions with all PPIs. Several hypotheses have been advanced, but no consensus has been reached. Read More

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https://www.karger.com/Article/FullText/493581
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http://dx.doi.org/10.1159/000493581DOI Listing
November 2018
15 Reads

Phenotypic Features of Central Sensitization.

Authors:
David A Williams

J Appl Biobehav Res 2018 Jun 27;23(2). Epub 2018 Jun 27.

Department of Anesthesiology, University of Michigan Health System, 24 Frank Lloyd Wright Drive, P.O. Box 385, Lobby M, Ann Arbor, MI 48106.

Purpose: The current manuscript reviews approaches for phenotyping central sensitization (CS).

Methods: The manuscript covers the concept of diagnostic phenotyping, use of endophenotypes, biomarkers, and symptom clusters. Specifically, the components of CS that include general sensory sensitivity (assessed by quantitative sensory testing) and a symptom cluster denoting sleep difficulties, pain, affect, cognitive difficulties, and low energy (S. Read More

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http://dx.doi.org/10.1111/jabr.12135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251410PMC
June 2018
2 Reads

Immediate-hypersensitivity reactions to proton pump inhibitors: Experience in a medical department.

Ann Allergy Asthma Immunol 2019 Feb 20;122(2):204-205. Epub 2018 Nov 20.

Allergy and Clinical Immunology Department, Coimbra's Universitary Hospital Centre, Coimbra, Portugal.

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http://dx.doi.org/10.1016/j.anai.2018.11.012DOI Listing
February 2019
8 Reads

Skin tests in patients with delayed and immediate hypersensitivity to heparins: A case series.

Contact Dermatitis 2019 Mar 18;80(3):170-172. Epub 2018 Nov 18.

Section of Clinical, Allergological and Venereological Dermatology, Department of Medicine, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1111/cod.13147DOI Listing
March 2019
4 Reads

Evaluation of the Potential Risk Factors for Drug-Induced Anaphylaxis in Adult Patients.

Int Arch Allergy Immunol 2019 16;178(2):167-176. Epub 2018 Nov 16.

Division of Immunology and Allergic Diseases, Department of Internal Medicine, Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Aim: To investigate the potential risk factors in patients who have experienced anaphylaxis from drugs.

Method: The study included 281 adult patients (median age 40 years; 76.5% female) who experienced immediate types of hypersensitivity reaction to a drug. Read More

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https://www.karger.com/Article/FullText/494130
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http://dx.doi.org/10.1159/000494130DOI Listing
November 2018
8 Reads

WITHDRAWN:Comparison of immediate hypersensitivity reaction rate according to the type of radiocontrast media.

Asian Pac J Allergy Immunol 2018 Oct 15. Epub 2018 Oct 15.

Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

The paper entitled "Comparison of immediate hypersensitivity reaction rate according to the type of radiocontrast media" by Hye Jung Park et al, which was published online on 15 October 2018, has been withdrawn at the authors' request. Read More

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http://apjai-journal.org/wp-content/uploads/2018/10/AP-19101
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http://dx.doi.org/10.12932/AP-191017-0182DOI Listing
October 2018
8 Reads

Immediate hypersensitivity to p-phenylenediamine.

Contact Dermatitis 2019 Mar 13;80(3):177-178. Epub 2018 Nov 13.

Coty Inc., Department of Toxicology, Darmstadt, Germany.

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http://dx.doi.org/10.1111/cod.13156DOI Listing
March 2019
1 Read

Prevention and management of acute reactions to intravenous iron in surgical patients.

Blood Transfus 2018 Oct 16:1-8. Epub 2018 Oct 16.

Perioperative Transfusion Medicine, Department of Surgical Specialties, Biochemistry and Immunology, School of Medicine, University of Málaga, Spain.

Absolute or functional iron deficiency is the most prevalent cause of anaemia in surgical patients, and its correction is a fundamental strategy within "Patient Blood Management" programmes. Offering perioperative oral iron for treating iron deficiency anaemia is still recommended, but intravenous iron has been demonstrated to be superior in most cases. However, the long-standing prejudice against intravenous iron administration, which is thought to induce anaphylaxis, hypotension and shock, still persists. Read More

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http://www.bloodtransfusion.it/articolosing.aspx?id=000985
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http://dx.doi.org/10.2450/2018.0156-18DOI Listing
October 2018
18 Reads

Nonsteroidal anti-inflammatory drug hypersensitivity in the Asia-Pacific.

Asia Pac Allergy 2018 Oct 23;8(4):e38. Epub 2018 Oct 23.

Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore 308433.

Nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity reactions (HSRs) are often nonimmunologically mediated reactions which present with immediate HSR type manifestations. These are mediated by cyclooxygenase inhibition resulting in shunting towards the excessive production of leukotrienes. Important disease associations include asthma, nasal polyposis, and chronic spontaneous urticaria, especially among adults. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5415/apallergy.2
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http://dx.doi.org/10.5415/apallergy.2018.8.e38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209595PMC
October 2018
1 Read

Mast cell disorders: From infancy to maturity.

Allergy 2019 Jan 28;74(1):53-63. Epub 2018 Nov 28.

Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.

Mast cells are typically linked to immediate hypersensitivity and anaphylaxis. This review looks beyond this narrow role, focusing on how these cells have evolved and diversified via natural selection promoting serine protease gene duplication, augmenting their innate host defense function against helminths and snake envenomation. Plasticity of mast cell genes has come at a price. Read More

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http://doi.wiley.com/10.1111/all.13657
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http://dx.doi.org/10.1111/all.13657DOI Listing
January 2019
21 Reads

Burden of Chronic Dermatophytosis in a Tertiary Care Hospital: Interaction of Fungal Virulence and Host Immunity.

Mycopathologia 2018 Dec 1;183(6):951-959. Epub 2018 Nov 1.

Department of Microbiology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, 110095, India.

Dermatophytosis is caused by keratinophilic dermatophytes and affects the superficial skin and its appendages. The nature of infection and response to treatment is influenced by host-pathogen factors like duration and severity of disease, prior drug history and type of causative organism. In our study, the burden of dermatophytosis affecting glabrous skin saw a rise in recalcitrant and reinfection cases with only 1. Read More

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http://dx.doi.org/10.1007/s11046-018-0303-4DOI Listing
December 2018
2 Reads
1.530 Impact Factor

Anaphylaxis-like reaction to anti-BRAF inhibitor dabrafenib confirmed by drug provocation test.

Melanoma Res 2019 02;29(1):95-98

Department of Medical Oncology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel.

The combination of BRAF and MEK inhibitors is a standard therapeutic option for patients with metastatic melanoma with BRAF-mutated tumors. This type of targeted therapy improved patient survival, having a manageable toxicity profile. Nevertheless, potentially life-threatening severe toxicity as anaphylaxis-like reactions was observed in two reported cases. Read More

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http://Insights.ovid.com/crossref?an=00008390-900000000-9923
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http://dx.doi.org/10.1097/CMR.0000000000000529DOI Listing
February 2019
11 Reads

Clopidogrel Hypersensitivity: Pathogenesis, Presentation and Diagnosis.

Curr Vasc Pharmacol 2019 ;17(2):110-112

Jane and Leonard Korman Respiratory Institute, Division of Pulmonary, Allergy & Critical Care Medicine, Allergy & Immunology Section, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, United States.

This paper provides an overview of the pathogenesis, presentation and diagnosis of clopidogrel hypersensitivity. The majority of clopidogrel hypersensitivity cases are due to a T cell mediated Gell and Coombs Type IV reaction. History, histology, and patch testing have shown consistency with a T cell mediated mechanism. Read More

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http://dx.doi.org/10.2174/1570161116666181031143628DOI Listing
January 2019
3 Reads