357,784 results match your criteria Hypersensitivity Reactions Delayed
J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.
Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Background: The most common immediate hypersensitivity to macrogols is associated with PEG 3350, however the epidemiology, mechanisms and cross-reactivity are poorly understood. Thousands of medications contain either PEGs or structurally similar polysorbates.
Objective: Our objective was to better understand the mechanism, cross-reactivity and scope of PEG hypersensitivity. Read More
J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.
Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. Electronic address:
Hemophagocytic lymphohistiocytosis (HLH) is an overwhelming clinical syndrome associated with extreme immune activation. Familial HLH is caused by autosomal recessive inheritance of gene mutations that cripple lymphocyte cytotoxicity. X-linked lymphoproliferative diseases and mutations in NLRC4 also feature HLH as a predominant manifestation. Read More
Pharmacoepidemiol Drug Saf 2018 Dec 17. Epub 2018 Dec 17.
Research Section, Uppsala Monitoring Centre, Uppsala, Sweden.
Purpose: Drug-induced aseptic meningitis (DIAM) is an inflammation of the membranes of the central nervous system caused by certain medications. It is a rare clinical entity whose risk factors are not yet fully elucidated. A local pattern of disproportionality within a global database of suspected adverse drug reactions (ADRs) revealed an increased reporting of aseptic meningitis and amoxicillin-clavulanic acid (AC) in males. Read More
Neuromodulation 2018 Dec 17. Epub 2018 Dec 17.
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Objectives: Spinal cord stimulation (SCS) represents an important neurostimulation therapy for pain. A new ultra-high frequency (10,000 Hz) SCS paradigm has shown improved pain relief without eliciting paresthesia. We aim to determine whether sub-sensory threshold SCS of lower frequencies also can inhibit mechanical hypersensitivity in nerve-injured rats and examine how electric charge delivery of stimulation may affect pain inhibition by different patterns of subthreshold SCS. Read More
Neuropharmacology 2018 Dec 13. Epub 2018 Dec 13.
Department of Psychiatry, University of Illinois at Chicago, USA. Electronic address:
Headaches are highly disabling and are among the most common neurological disorders worldwide. Despite the high prevalence of headache, therapeutic options are limited. We recently identified the delta opioid receptor (DOR) as an emerging therapeutic target for migraine. Read More
Ann Allergy Asthma Immunol 2018 Dec 12. Epub 2018 Dec 12.
Allergy Department Hospital Universitario 12 de Octubre, Avenida de Córdoba s/n, Postal code 28041 , Madrid, Spain.
Lung 2018 Dec 14. Epub 2018 Dec 14.
Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75219, USA.
J Physiol Pharmacol 2018 Aug 9;69(4). Epub 2018 Dec 9.
First Department of Medicine, Hector Center for Nutrition, Exercise and Sports, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen, Germany.
Histamine intolerance represents a controversially discussed disorder. Besides an impaired degradation of orally supplied histamine due to diamine oxidase (DAO) deficiency, a deranged gut flora may also contribute to elevated histamine levels. Our aim was to determine the intestinal bacterial composition in patients with proven histamine intolerance in comparison to other food intolerances and healthy controls. Read More
Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.
Chemical Biology Laboratory, Department of Biotechnology, Indian Institute of Technology Roorkee, Uttarakhand 247 667, India.
Inappropriate and disproportionate use of antibiotics is contributing immensely to the development of antibiotic resistance in bacterial species associated with food contamination. Use of natural products in combination can be a potent alternative hurdle strategy to inactivate foodborne pathogens. Here, we explored pro-oxidant properties of essential oil inalool and itamin C in combination with opper (LVC) in combating foodborne pathogens and a subsp. Read More
Biomed Pharmacother 2019 Jan 26;109:2014-2021. Epub 2018 Nov 26.
Orthopedics Department, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Pudong, Shanghai, 201399, China. Electronic address:
Spinal cord injury (SCI) is a devastating event, leading to the progression of chronic neuropathic pain syndrome. Triggering receptor expressed on myeloid cells 1 (TREM1) is an innate immune receptor expressed on neutrophils and monocytes/macrophages. TREM1 enhances inflammatory response in various models of diseases, but its significance in SCI remains unclear. Read More
Biomed Pharmacother 2019 Jan 5;109:1000-1007. Epub 2018 Nov 5.
Research Department, Innlandet Hospital Trust, Brumunddal, Norway; Inland Norway University of Applied Sciences, Elverum, Norway.
Chronic fatigue syndrome (CFS) is known as a multi-systemic and complex illness, which induces fatigue and long-term disability in educational, occupational, social, or personal activities. The diagnosis of this disease is difficult, due to lacking a proper and suited diagnostic laboratory test, besides to its multifaceted symptoms. Numerous factors, including environmental and immunological issues, and a large spectrum of CFS symptoms, have recently been reported. Read More
Pharmacol Rep 2018 Oct 6;71(1):139-148. Epub 2018 Oct 6.
Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland. Electronic address:
Background: The G protein-coupled receptor 35 (GPR35), is considered important for nociceptive transmission, as suggested by accumulating evidence. This receptor was discovered in 1998; however, a lack of pharmacological tools prevented a complete understanding of its function and how to exploit it therapeutically. We studied the influence of CXCL17, kynurenic acid and zaprinast on nociceptive transmission in naïve and neuropathic mice. Read More
Surv Ophthalmol 2018 Dec 11. Epub 2018 Dec 11.
Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Vernal keratoconjunctivitis, a chronic, bilateral, seasonal allergic inflammatory disease of the eye, is an important cause of visual debilitation and impairment of quality of life in children and young adults in certain parts of the world such as the Mediterranean areas, Central and West Africa, the Middle East, Japan, the Indian subcontinent, and South America. It usually has a self-limiting course; however, in a few cases the disease is recurrent and leads to long-term visual disabling complications like keratoconus and limbal stem cell deficiency. The main pathogenic mechanism is IgE mediated; however, there may be non-IgE and certain non-specific hypersensitivity mechanisms. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1779-1783
Department of Allergy, Beijing Shijitan Hospital, Affiliated to Capital Medical University, Beijing, 100038, China.
To investigate the incidence of plant food allergy in patients with pollinosis and the effect of food allergens on the clinical symptoms of pollinosis patients. A total of 40 patients with pollinosis and food allergy attended to the allergy Department of Duolun People's Hospital of Inner Mongolia were accepted skin prick test of inhaled allergens while the rhino conjunctivitis quality of life questionnaire(RQLQ) were also completed. The patients were divided into A and B groups randomly. Read More
Rev Med Suisse 2018 Dec;14(631):2243-2247
Service d'orthopédie et traumatologie, Département de l'appareil locomoteur, CHUV, 1011 Lausanne.
So-called metal allergy is a new interesting subject in orthopedics. Two different ways of thinking prevail in the literature. In the German orthopaedic literature, the diagnosis of metal allergy is often described and considered a real pathology, while we can find a more skeptical approach to this entity in Anglo-Saxons literature. Read More
Hum Brain Mapp 2018 Dec 13. Epub 2018 Dec 13.
Gillberg Neuropsychiatry Centre (GNC), University of Gothenburg, Gothenburg, Sweden.
Gamma oscillations facilitate information processing by shaping the excitatory input/output of neuronal populations. Recent studies in humans and nonhuman primates have shown that strong excitatory drive to the visual cortex leads to suppression of induced gamma oscillations, which may reflect inhibitory-based gain control of network excitation. The efficiency of the gain control measured through gamma oscillations may in turn affect sensory sensitivity in everyday life. Read More
Eur J Immunol 2018 Dec 13. Epub 2018 Dec 13.
School of Biosciences, University of Birmingham, United Kingdom.
Front Immunol 2018 28;9:2796. Epub 2018 Nov 28.
Department for Immunobiochemistry, Universitätsmedizin Mannheim, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Germany.
Natural Killer (NK) cells are cytotoxic innate lymphoid cells serving at the front line against infection and cancer. In inflammatory microenvironments, multiple soluble and contact-dependent signals modulate NK cell responsiveness. Besides their innate cytotoxic and immunostimulatory activity, it has been uncovered in recent years that NK cells constitute a heterogeneous and versatile cell subset. Read More
Neuropsychobiology 2018 Dec 13:1-6. Epub 2018 Dec 13.
Department of Neurology, Dokkyo Medical University, Mibu,
Background: Photophobia is a common feature of migraine, which may involve abnormal cortical information processing. In electroencephalograms (EEG), photic driving is known as a reaction to visual stimulation. Both photophobia and photic driving response are present during light stimulation. Read More
Int Arch Allergy Immunol 2018 Dec 13:1-5. Epub 2018 Dec 13.
Division of Allergy and Clinical Immunology, St. Michael's Hospital, University of Toronto, Toronto, Ontario,
Background: Ibuprofen is the most frequently used over-the-counter nonsteroidal anti-inflammatory drug (NSAID) in North America. While it has been commonly implicated in drug-induced hypersensitivity reactions, there is limited literature specifically on ibuprofen hypersensitivity.
Objectives: To characterize the demographics and clinical course of hypersensitivity reactions in a cohort of patients with ibuprofen allergy. Read More
Front Plant Sci 2018 6;9:1634. Epub 2018 Nov 6.
State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan, China.
Nitric oxide (NO) production via NO synthase (NOS) plays a vital role in plant tolerance to salt stress. However, the factor(s) regulating NOS-like activity in plant salt stress tolerance remains elusive. Here, we show that (), which can restore HO-induced NO accumulation in yeast Δ mutant, functions in plant salt stress tolerance. Read More
Curr Treat Options Allergy 2018 1;5(4):436-444. Epub 2018 Oct 1.
2Erasmus Medical Center, Department of Internal Medicine, Section of Allergology, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Purpose Of Review: To describe and understand the links and interactions between food allergy and asthma.
Recent Findings: Food allergy and asthma are characterized by an increasing prevalence. Moreover, food allergy and asthma often coexist. Read More
High Alt Med Biol 2018 Dec 4. Epub 2018 Dec 4.
Department of Physiology, University College of Science and Technology, University of Calcutta , Kolkata, India .
Goswami, Ananda Raj, and Tusharkanti Ghosh. Vitamin E reduces hypobaric hypoxia-induced immune responses in male rats. High Alt Med Biol 00:000-000, 2018. Read More
Diabetes Ther 2018 Dec 6. Epub 2018 Dec 6.
Medical Clinic and Policlinic III at the University Hospital Dresden, Dresden, Germany.
In the original publication, the text in Table 2 stated 'Hypersensitivity to the active substance, to Ferinject, or to any of its excipients'. Read More
Cell Mol Life Sci 2018 Dec 6. Epub 2018 Dec 6.
Monash Centre of Cardiovascular Research and Education in Therapeutics, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Dihydrosphingolipids refer to sphingolipids early in the biosynthetic pathway that do not contain a C4-trans-double bond in the sphingoid backbone: 3-ketosphinganine (3-ketoSph), dihydrosphingosine (dhSph), dihydrosphingosine-1-phosphate (dhS1P) and dihydroceramide (dhCer). Recent advances in research related to sphingolipid biochemistry have shed light on the importance of sphingolipids in terms of cellular signalling in health and disease. However, dihydrosphingolipids have received less attention and research is lacking especially in terms of their molecular mechanisms of action. Read More
J Neurosci 2018 Dec 6. Epub 2018 Dec 6.
Departments of Neurology
Autism spectrum disorders (ASD) are often associated with atypical sensory processing and sensory hypersensitivity, which can lead to maladaptive behaviors, such as tactile defensiveness. Such altered sensory perception in ASD could arise from disruptions in experience-dependent maturation of circuits during early brain development. Here, we tested the hypothesis that synaptic structures of primary somatosensory cortex (S1) neurons in Fragile X syndrome (FXS), which is a common inherited cause of autism, are not modulated by novel sensory information during development. Read More
J Pharmacol Sci 2018 Nov 24. Epub 2018 Nov 24.
Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan; Department of General Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan.
Visceral hypersensitivity and impaired gut barrier with minor inflammation are considered to play an important role in the pathophysiology of irritable bowel syndrome (IBS). Since pioglitazone is known to have anti-inflammatory property, we hypothesized that pioglitazone is beneficial for treating IBS. In this study, the effect was tested in rat IBS models such as lipopolysaccharide or repeated water avoidance stress-induced visceral allodynia and increased colonic permeability. Read More
BMC Cancer 2018 Dec 6;18(1):1224. Epub 2018 Dec 6.
Department of Urology, Fondazione Policlinico Universitario "A. Gemelli" IRCSS, Largo Agostino Gemelli, 8, 00168, Rome, Italy.
Background: In case of high grade non-muscle invasive bladder cancer (HG-NMIBC), intravesical BCG represents the first-line treatment; despite the "gold" standard therapy, up to 50% of patients relapse, needing radical cystectomy. Hence, alternative therapeutic strategies have been developed. The aim of the study was to evaluate a first-line salvage treatment with EMDA®-MMC in patients with HGNMIBC unresponsive to BCG. Read More
Lab Anim 2018 Dec 6:23677218815718. Epub 2018 Dec 6.
1 Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Italy.
Ulcerative dermatitis (UD) is an idiopathic, spontaneous and progressive disease typically affecting C57BL/6 aged mice with an unknown aetiopathogenesis. For this study, we evaluated 25 cases of UD in C57BL/6NCrl-Tg(HMGA1P6)1Pg mice. Formalin-fixed, paraffin-embedded skin samples were submitted to morphological investigations. Read More
J Int Med Res 2018 Dec 7:300060518814118. Epub 2018 Dec 7.
1 Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Wangfujing, Beijing, China.
Cefuroxime is a second-generation cephalosporin antibiotic that causes immediate hypersensitivity reactions, ranging from mild urticaria to severe anaphylactic shock. Anaphylactic reactions typically involve multiple systems, most notably, the skin and the respiratory and cardiovascular systems. Here, we report the unusual case of a patient who presented with oral cefuroxime-induced anaphylaxis with prominent neurologic manifestations. Read More
PLoS Genet 2018 Dec 12;14(12):e1007821. Epub 2018 Dec 12.
Cancer Genomics Unit, Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Fanconi Anemia (FA) is a genomic instability syndrome resulting in aplastic anemia, developmental abnormalities, and predisposition to hematological and other solid organ malignancies. Mutations in genes that encode proteins of the FA pathway fail to orchestrate the repair of DNA damage caused by DNA interstrand crosslinks. Zebrafish harbor homologs for nearly all known FA genes. Read More
JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.
Office of Surveillance and Epidemiology, Division of Pharmacovigilance, FDA Center for Drug Evaluation and Research, Silver Spring, Maryland.
Importance: The US Food and Drug Administration (FDA) conducts ongoing public health safety surveillance for drug and therapeutic biologic products. Identifying cases of acute and subacute noninfectious pneumonia supports the public health mission of the FDA.
Objective: To identify and analyze postmarketing cases of noninfectious pneumonia associated with ustekinumab use. Read More
JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.
Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Adv Exp Med Biol 2018 ;995:131-149
Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Checkpoint inhibitors are part of the family of immunotherapies and are increasingly being used in a wide variety of cancers. Immune-related adverse events pose a major challenge in the treatment of cancer patients. Pneumonitis is a rare immune-related adverse event that presents in distinct patterns. Read More
Int Orthop 2018 Dec 11. Epub 2018 Dec 11.
Department of Orthopaedics and Trauma Surgery, University Hospital Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany.
Purpose: The contact allergens nickel, cobalt, and chromium are often discussed as possible triggers of allergic reactions to orthopedic implants. Additionally, acrylates and polymerization additives in bone cement (e.g. Read More
Clin Cosmet Investig Dermatol 2018 23;11:603-611. Epub 2018 Nov 23.
Institute of Medical and Biomedical Education, St George's University of London, London, UK.
The recent rapid growth in dermal filler use, in conjunction with inadequate product and injector control, has heralded a concerning increase in filler complications. The 10-point plan has been developed to minimize complications through careful preconsideration of causative factors, categorized as patient, product, and procedure related. Patient-related factors include history, which involves a preprocedural consultation with careful elucidation of skin conditions, systemic disease, medications, and previous cosmetic procedures. Read More
Onco Targets Ther 2018 21;11:8239-8250. Epub 2018 Nov 21.
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan,
Standard treatment options for patients with advanced gastric cancer (GC) offer limited efficacy and are associated with some toxicity, which necessitates the development of more effective therapies for improving the treatment outcomes for this disease. Immunotherapy involving immune checkpoint inhibitors (ICIs) which inhibit the programmed death 1 (PD-1)/programmed death ligand 1 interaction has emerged as a new treatment option. Nivolumab, a human IgG4 monoclonal antibody inhibitor of PD-1, has demonstrated promising clinical activity and induced durable responses in patients with advanced GC. Read More
Iran J Allergy Asthma Immunol 2018 Aug 12;17(4):393-397. Epub 2018 Aug 12.
Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.
Efficient diagnosis of allergy and proper treatment need identification of the causative allergens eliciting clinical symptoms. The present study was performed to identify the most common aero- and food allergens and determine the pattern of sensitization among people of Ahvaz (southwestern Iran), one of the most polluted cities worldwide. Based on the physical examination and medical records, patients were referred to the Allergy laboratory for "in vitro" IgE determination. Read More
Contact Dermatitis 2018 Dec 10. Epub 2018 Dec 10.
Department of Cutaneous Allergy, St John's Institute of Dermatology, Guy's & St Thomas' NHS Foundation Trust, London, UK.
There is a lack of published data on the role of patch testing in patients with so-called multiple chemical sensitivity (MCS), also known as idiopathic environmental intolerances (IEI). This disputed chronic condition is characterised by symptoms that the affected person attributes to low-level exposures to commonly used chemicals. Symptoms are typically vague and non-specific and may include fatigue, headaches, nausea, dizziness, a sensation of skin burning or pain. Read More
J Small Anim Pract 2018 Dec 11. Epub 2018 Dec 11.
Re-Fur-All Referrals, Newbury, Berkshire, UK.
Food intolerance refers to any abnormal physiological response to a food or food additive, believed not to be immunological in nature. Mechanisms include food toxicity, pharmacological reactions, metabolic reactions, dysmotility, dysbiosis, physical effects and non-specific dietary sensitivity. Food intolerance reactions are variable, typically dose-dependent, and can occur at any age. Read More
J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.
Department of Anesthesiology, Quzhou Hospital of Zhejiang University School of Medicine, Quzhou, China.
Peripheral inflammation in male C57BL/6 mice was induced by intraplantar injection of 20 μL complete freund's adjuvant (CFA) in the left hind paw. Mice were randomly divided into three groups: Sham, CFA, and propofol+CFA. Mechanical allodynia was assessed by von Frey analysis, and heat hyperalgesia was detected by exposure of the plantar surface to a beam of radiant heat. Read More
Drug Saf 2018 Dec 10. Epub 2018 Dec 10.
Vifor Pharma Management Ltd., Flughofstrasse 61, 8152, Glattbrugg, Switzerland.
Introduction: Hypersensitivity reactions (HSRs) are among the known adverse events of intravenous (i.v.) iron products. Read More
Inflamm Bowel Dis 2018 Dec 11. Epub 2018 Dec 11.
Department of Gastroenterology, Hepatology & Nutrition, Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.
Scientific research into the effects and mechanisms of acupuncture for gastrointestinal diseases including inflammatory bowel disease has been rapidly growing in the past several decades. In this review, we discuss the history, theory, and methodology of acupuncture and review potentially beneficial mechanisms of action of acupuncture for managing inflammatory bowel disease. Acupuncture has been shown to decrease disease activity and inflammation via increase of vagal activity in inflammatory bowel disease. Read More
Pain Rep 2018 Sep-Oct;3(5):e676. Epub 2018 Sep 17.
Peripheral Neuropathy Unit, Centre for Clinical Translation, Department of Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom.
Introduction: Granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR) is highly expressed in peripheral macrophages and microglia, and is involved in arthritis and cancer pain in animal models. However, there is limited information on GM-CSFR expression in human central nervous system (CNS), peripheral nerves, or dorsal root ganglia (DRG), particularly in chronic pain conditions.
Objectives: Immunohistochemistry was used to quantify GM-CSFR expression levels in human tissues, and functional sensory effects of GM-CSF were studied in cultured DRG neurons. Read More
Cell Mol Gastroenterol Hepatol 2019 20;7(1):185-196. Epub 2018 Sep 20.
Université Lille, INSERM, CHR Lille, Lille Inflammation Research International Center, U995, Lille, France.
Background & Aims: Irritable bowel syndrome (IBS) is a multifactorial disease arising from a complex interplay between genetic predisposition and environmental influences. To date, environmental triggers are not well known. Aluminum is commonly present in food, notably by its use as food additive. Read More
Hip Pelvis 2018 Dec 6;30(4):276-281. Epub 2018 Dec 6.
Department of Orthopaedics, Korea University Guro Hospital, Seoul, Korea.
Pseudotumors are not uncommon complications after total hip arthroplasty (THA) and may occur due to differences in bearing surfaces of the head and the liner ranging from soft to hard articulation. The most common causes of pseudotumors are foreign-body reaction, hypersensitivity and wear debris. The spectrum of pseudotumor presentation following THA varies greatly-from completely asymptomatic to clear implant failure. Read More
Nurs Open 2019 Jan 19;6(1):136-143. Epub 2018 Aug 19.
Department of Health VID Specialized University Oslo Norway.
Aim: To investigate a possible association between children's current diet and parents' reported avoidance of appropriate foods in the child's diet at the age of 10 months, due to fears of allergic or hypersensitivity reactions.
Design: A cross-sectional study.
Methods: In 10 randomly selected municipalities willing to participate, 686 children represented by their parents visiting the child health centre were enrolled in the study. Read More
Front Pharmacol 2018 23;9:1360. Epub 2018 Nov 23.
Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.
(FLL) has been widely used as a traditional Chinese medicine (TCM) for treating soreness and weakness of waist and knees. It has potential for treating OA owing to its kidney-tonifying activity with bone-strengthening effects, but there is so far no report of its anti-OA effect. This study established a rat OA model by intra-articular (IA) injection of mono-iodoacetate (1. Read More
J Clin Invest 2018 Dec 11. Epub 2018 Dec 11.
Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated subchondral bone remodeling in sensory innervation for OA pain. We show that osteoclasts secrete NETRIN1 to induce sensory nerve axonal growth in subchondral bone. Read More
J Exp Med 2018 Dec 7. Epub 2018 Dec 7.
Leibniz Institute on Aging, Fritz Lipmann Institute (FLI), Jena, Germany
Organism aging is characterized by increased inflammation and decreased stem cell function, yet the relationship between these factors remains incompletely understood. This study shows that aged hematopoietic stem and progenitor cells (HSPCs) exhibit increased ground-stage NF-κB activity, which enhances their responsiveness to undergo differentiation and loss of self-renewal in response to inflammation. The study identifies /cohesin as a critical mediator of NF-κB signaling, which increases chromatin accessibility in the vicinity of NF-κB target genes in response to inflammation. Read More