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Harefuah 2022 Aug;161(8):481-486

Department of Internal Medicine "T", Chaim Sheba Medical Center, Tel-Hashomer.

Introduction: A male patient aged 81, with a history of atrial fibrillation, pacemaker implantation and hip replacement was admitted due to pneumonia. Subsequent Methicillin Sensitive Staphylococcus Aureus (MSSA) bacteremia and septic arthritis of his prosthetic joint was diagnosed, and treated with Oxacillin. Two weeks later, an exanthematous rash appeared, involving most of his body surface, evolving to blisters that dried up and led to extensive exfoliation of the skin, consistent with a delayed type hypersensitivity drug reaction. Read More

World J Clin Cases 2022 Jul;10(19):6695-6701

Department of Dermatology, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China.

Background: Many ant species can harm humans; however, only a few cause life-threatening allergic reactions. Normally, reactions caused by ants occur in patients who come into contact with ant venom. Venom contains various biologically active peptides and protein components, of which acids and alkaloids tend to cause anaphylaxis. Read More

Br J Clin Pharmacol 2022 Aug 16. Epub 2022 Aug 16.

Department of Pediatrics, Division of Dermatology and Rheumatology, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.

Drug-induced skin disease or cutaneous adverse drug reactions (CADRs) are terms that encompass the clinical manifestations of the skin, mucosae and adnexa induced by a drug or its metabolites. The skin is the organ most frequently affected by drug reactions, which may affect up to 10% of hospitalized patients and occur in 1% to 3% of multi-medicated patients. Most CADRs are mild or self-resolving conditions; however, 2% to 6. Read More

HLA 2022 Aug 15. Epub 2022 Aug 15.

Institute for Immunology and Infectious Diseases (IIID), Murdoch University, Perth, Australia.

Human leukocyte antigen (HLA) alleles are risk factors for CD8+ T-cell mediated drug hypersensitivity reactions. However, as most HLA associations are incompletely predictive and/or involve risk alleles at low frequency, costly sequence-based typing can elude an economically productive cost: benefit ratio for clinical validation studies and diagnostic and/or preventative screening. Hence rapid and low-cost detection assays are now required, both for single alleles but also across risk loci associated with broader multi-disease risk; exemplified by associations with diverse alleles in HLA-B*35, including HLA-B*35:01 and green tea- or co-trimoxazole-induced liver injury. Read More

Qatar Med J 2022 4;2022(2). Epub 2022 Apr 4.

Adult Allergy and Immunology Section, Department of Medicine, Hamad Medical Corporation, Doha, Qatar E-mail:

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) cause different types of allergic and pseudo allergic reactions. This results in difficulties in clinical practice. Most cases of NSAID hypersensitivity are mediated by the inhibition of cyclooxygenase-1 enzyme (COX-1), which results in depletion of the protective prostaglandin E2, and promotes the unrestrained synthesis of inflammatory mediators from mast cells. Read More

Front Immunol 2022 28;13:901851. Epub 2022 Jul 28.

Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Background: Chronic inducible urticaria (CIndU) constitutes a group of nine different CIndUs in which pruritic wheals and/or angioedema occur after exposure to specific and definite triggers. Histamine released from activated and degranulating skin mast cells is held to play a key role in the pathogenesis of CIndU, but evidence to support this has, as of yet, not been reviewed systematically or in detail. We aim to characterize the role and relevance of histamine in CIndU. Read More

Front Immunol 2022 28;13:814064. Epub 2022 Jul 28.

Department of Pharmacology, University of Oxford, Oxford, United Kingdom.

Approval of B-cell-depleting therapies signifies an important advance in the treatment of multiple sclerosis (MS). However, it is unclear whether the administration route of anti-CD20 monoclonal antibodies (mAbs) alters tissue distribution patterns and subsequent downstream effects. This study aimed to investigate the distribution and efficacy of radiolabeled ofatumumab and ocrelizumab in humanized-CD20 (huCD20) transgenic mice following subcutaneous (SC) and intravenous (IV) administration. Read More

Asia Pac Allergy 2022 Jul 22;12(3):e30. Epub 2022 Jul 22.

Immunoallergology Department, Centro Hospitalar de Setúbal E.P.E., Setúbal, Portugal.

Stevens-Johnson syndrome is a rare severe delayed-type hypersensitivity reaction. Even though not initially described as a side-effect of the Comirnaty® coronavirus disease 2019 (COVID-19) Vaccine, the worldwide public COVID-19 vaccination programs are uncovering this serious adverse event. We present the case of a 44-year-old woman, vaccinated with the 1st dose in July 2021, and the 2nd dose 4 weeks later. Read More

J Anim Sci 2022 Aug 15. Epub 2022 Aug 15.

Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Purported benefits of human-grade pet foods include reduced inflammation, enhanced coat quality, and improved gut health, but research is scarce. Therefore, we compared gene expression, skin and coat health measures, and the fecal microbiome of dogs consuming a mildly-cooked human-grade or extruded kibble diet. Twenty beagles (BW=10. Read More

J Infect Chemother 2022 Aug 10. Epub 2022 Aug 10.

Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Introduction: Phenazopyridine is an azo dye, which exerts local anesthetic or analgesic action on urinary tract mucosa through an unknown mechanism. Besides its common complications including orange discoloration of the urine and gastrointestinal problems, it may have rare side effects like hemolytic anaemia, methemoglobinemia, renal failure, and skin changes. We reported a paraplegic man with skin ulcers on scretom and right foot after about 3 days of phenazopyridine use CASE REPORT: A 62-year-old man presented with flesh shaped deep ulcers in lower parts of the body. Read More

Actas Dermosifiliogr 2022 Aug 8. Epub 2022 Aug 8.

Servicio de Dermatología, Hospital Universitario 12 de Octubre, Madrid, España; AG BIOMEDIC CLINIC, Madrid, España. Electronic address:

SARS-CoV-2 has caused millions of infections and deaths worldwide and case numbers continue to rise. Besides the effect of the virus on key organs - leading to respiratory illness, anosmia, diarrhea, and fever and other complications - delayed inflammatory reactions to hyaluronic acid dermal fillers, mainly in the face, have also been reported to occur after confirmed SARS-CoV-2 infections and in vaccinated individuals. While delayed inflammatory reactions tend to be self-limiting, they should be diagnosed and treated with corticosteroids, hyaluronidase, and/or antibiotics when necessary. Read More

Cureus 2022 Jul 6;14(7):e26613. Epub 2022 Jul 6.

Respiratory Medicine, Apley Medical Ltd, San Fernando, TTO.

Paclitaxel-induced pneumonitis (PIP) is an immune-mediated disease resulting from a delayed hypersensitivity reaction (type IV) to paclitaxel, an anti-microtubule chemotherapeutic drug commonly used to treat breast cancer in both neoadjuvant and adjuvant settings. PIP is diagnosed by exclusion utilizing laboratory work-up, imaging, biopsy studies, and results of antibiotic therapy because there is no single diagnostic test. Ground-glass opacifications on CT, coupled with minimal restrictive disturbance with decreased diffusion on pulmonary function tests (PFTs), negative bronchoalveolar lavage (BAL), and bronchoscopy cultures, may assist physicians in diagnosing paclitaxel-induced pneumonitis. Read More

Toxicon 2022 Aug 5;217:41-45. Epub 2022 Aug 5.

Institut de Systématique, Evolution, Biodiversité, (UMR 7205 Muséum National d'Histoire Naturelle, CNRS UPMC EPHE, Sorbonne Universités), CP30, 25 Rue Cuvier, 75005, Paris, France.

The mixed quality evidence about non-front-fanged snake bites has included unsupported speculation and presumption; the possible role of atopy and/or primary hypersensitivity have often been prematurely discounted. Described is a medically insignificant bite by a captive African emerald snake, Hapsidophrys smaragdinus Schlegel, 1837 (Colubridae, Colubrinae) that caused the development of moderate Type IV hypersensitivity; the 44-year-old male victim experienced persistent pruritis and an erythematous bite site maculopapular dermatitis that slowly resolved and required 6 days for full resolution. The victim had received several previous medically insignificant bites from non-front-fanged snakes. Read More

Microbiol Spectr 2022 Aug 8:e0135722. Epub 2022 Aug 8.

Hospital Interzonal General de Agudos Eva Perón, Buenos Aires, Argentina.

Dermatitis is the most common adverse event during treatment with benznidazole in chronic Chagas disease and is probably mediated by T cells. A set of molecules representative of the different type IV hypersensitivity reactions was evaluated in the circulation and skin biopsies of Trypanosoma cruzi-infected subjects presenting dermatitis during benznidazole administration. Through cytometric bead assays and enzyme-linked immunosorbent assay capture techniques, the serum levels of cytokines, chemokines, proapoptotic molecules, and mediators of the activation and migration of eosinophils and T cells were measured in subjects infected with Trypanosoma cruzi who exhibited skin adverse events ( = 22) and compared with those without adverse events ( = 37) during benznidazole therapy. Read More

J Child Adolesc Psychopharmacol 2022 Aug 15;32(6):349-357. Epub 2022 Jul 15.

Centre for Big Data Research in Health, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.

Children who are relatively young for their school grade are more likely to receive treatment for attention-deficit/hyperactivity disorder (ADHD). It is unclear whether the phenomenon also exists across Australia or is impacted by the school enrolment policy in place. We evaluated the association between children's relative age and initiation of ADHD medicines across Australian jurisdictions with different school enrolment policies and rates of delayed school entry. Read More

Therapie 2022 Jun 30. Epub 2022 Jun 30.

Service régional de pharmacovigilance de Sfax, faculté de médecine de Sfax, université de Sfax, avenue Majida Boulila, 3029 Sfax, Tunisie.

Pain Ther 2022 Jul 31. Epub 2022 Jul 31.

Kiel Migraine and Headache Centre, Heikendorfer Weg 9-27, 24149, Kiel, Germany.

Introduction: Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), formerly also called baboon syndrome, is characterized by symmetrical erythematous rash with typical localization in the gluteal and intertriginous areas. A type IV delayed hypersensitivity immune response is thought to be responsible for its development. CGRP monoclonal antibodies (CGRP mAbs) are a new class of drugs for the prevention of migraine. Read More

Lancet Public Health 2022 08;7(8):e694-e704

Department of Environmental Health, Harvard T H Chan School of Public Health, Boston, MA, USA. Electronic address:

Background: Housing conditions are a key driver of asthma incidence and severity. Previous studies have shown increased emergency department visits for asthma among residents living in poor-quality housing. Interventions to improve housing conditions have been shown to reduce emergency department visits for asthma, but identification and remediation of poor housing conditions is often delayed or does not occur. Read More

Int Immunopharmacol 2022 Jul 27;111:109081. Epub 2022 Jul 27.

Department of Pharmacy, Forman Christian College (A Chartered University), Lahore, Pakistan.

Magnoflorine shows a diverse range of pharmacological actions, including immunomodulatory, antioxidant and neuropharmacological activities. However, its effects on the immune responses in animal studies have not been reported. In this study, magnoflorine isolated from Tinospora crispa, at doses of 25, 50 and 100 mg/kg was administered to male Balb/c mice daily for 14 days to evaluate its effect on innate immune responses, while for evaluation of adaptive immune responses, on day 0 the mice were injected intraperitoneally with sheep red blood cells (sRBC) and treated orally with the various doses of magnoflorine for the same duration. Read More

BMC Infect Dis 2022 Jul 28;22(1):658. Epub 2022 Jul 28.

Department of Biological Sciences, University of Tasmania, Private Bag 55, Hobart, TAS, Australia.

Background: Sarcoptes scabiei is one of the most impactful mammalian parasites. There has been much research on immunological and clinical pathological changes associated with S. scabiei parasitism across a range of host species. Read More

Vet Immunol Immunopathol 2022 Jul 13;251:110460. Epub 2022 Jul 13.

Laboratorio de Tecnología Inmunológica (Facultad de Bioquímica y Cs Biológicas Universidad Nacional del Litoral) - Santa Fe - Argentina - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Bs.As., Argentina. Electronic address:

Low-cost adjuvants are urgently needed for the development of veterinary vaccines able to trigger strong immune responses. In this work, we describe a method to obtain a low-cost cage-like particles (ISCOMATRIX-like) adjuvant useful to formulate veterinary vaccines candidates. The main components to form the particles are lipids and saponins, which were obtained from egg yolk by ethanolic extraction and by dialyzing a non-refined saponins extract, respectively. Read More

J Asthma Allergy 2022 18;15:957-970. Epub 2022 Jul 18.

SaBio (Health and Biotechnology), Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ciudad Real, 13005, Spain.

The α-Gal syndrome (AGS) is a pathognomonic immunoglobulin E (IgE)-mediated delayed anaphylaxis in foods containing the oligosaccharide galactose-α-1,3-galactose (α-Gal) such as mammalian meat or dairy products. Clinical presentation of AGS can also comprise immediate hypersensitivity due to anticancer therapy, gelatin-containing vaccines or mammalian serum-based antivenom. The IgE initial sensitization is caused by hard-bodied tick bites and symptomatic individuals typically develop delayed pruritus, urticaria, angioedema, anaphylaxis, malaise or gut-related symptoms. Read More

Toxicology 2022 Jul 22;477:153272. Epub 2022 Jul 22.

Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. Electronic address:

There are few reports concerning electronic nicotine delivery system (ENDS) use during pregnancy and no studies on asthma in prenatally JUUL-exposed offspring. Here, we tested the hypothesis that in utero JUUL exposure causes unfavorable birth outcomes and lasting pulmonary health effects in adult offspring. BALB/c dams were exposed to either air or mint-flavored JUUL aerosol, 1-hr/d, 20 consecutive days during gestation. Read More

J Allergy Clin Immunol Pract 2022 Jul 20. Epub 2022 Jul 20.

Department of Dermatology, Henri Mondor Hospital, AP-HP, Créteil, France; Department of Allergy and Clinical Immunology, Edouard Herriot Hospital, HCL, Claude Bernard Lyon 1 University, Lyon, France; Reference Center for Toxic Bullous Dermatoses and Severe Drug Reactions (TOXIBUL), Créteil, France. Electronic address:

Background: There are limited data on the use of skin testing, other than patch testing, and challenges in the evaluation of epidermal necrolysis (EN), including Stevens-Johnson syndrome and toxic epidermal necrolysis.

Objective: To report a French multicenter experience in skin testing and challenges in EN, and investigate the factors associated with tests' positivity.

Methods: All patients who were evaluated by patch tests (PTs), skin prick tests, intradermal tests (IDTs), or drug provocation tests (DPTs) for EN between 2010 and 2020 were retrospectively included through 2 French drug reaction networks. Read More

PLoS One 2022 21;17(7):e0271336. Epub 2022 Jul 21.

Department of Physical Therapy, University of Haifa, Haifa, Israel.

Objective: To investigate the: (1) role of basic muscle pain sensitivity and psychological factors in the prediction of movement-evoked pain (MEP) following delayed onset muscle soreness (DOMS), and (2) association of MEP with changes in systemic muscle pain sensitivity following DOMS induction.

Methods: Fifty-one participants were assigned to either eccentric resistance exercise or control groups. They completed questionnaires evaluating psychological distress and underwent muscle pain sensitivity evaluation by the pressure pain threshold (PPT) test at the exercised and remote muscles, before and 24 hours following the intervention. Read More

Ann Allergy Asthma Immunol 2022 Jul 14. Epub 2022 Jul 14.

Centro Pediatrico del Mendrisiotto, Mendrisio, Switzerland; Pediatric Allergy Unit, Department of Woman, Child, and Adolescent, University Hospitals of Geneva, Geneva, Switzerland; Faculty of Biomedical Science, Università della Svizzera Italiana (USI), Lugano, Switzerland. Electronic address:

Eur J Pharmacol 2022 Aug 13;929:175151. Epub 2022 Jul 13.

College of Pharmacy, Southwest Minzu University, Chengdu, 610225, Sichuan, PR China. Electronic address:

A series of novel scopariusicide derivatives were designed and synthesized starting from the main diterpenoid from the aerial parts of Isodon scoparius. Sis-25 was the most effective compound among them. The potential mechanism(s) of its immunosuppressive activity in vitro, as well as its effects on delayed type hypersensitivity (DTH) reaction and imiquimod-induced dermatitis in vivo were investigated in this study. Read More

Allergy Asthma Immunol Res 2022 Jul;14(4):348-360

Department of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, Germany.

Iodinated contrast media (ICM) have become one of the major causes of drug hypersensitivity reactions (HSRs) related to increasing numbers of ICM-based radiological imaging procedures. Strategies for diagnosing and preventing ICM-induced HSRs have not been uniformly standardized yet. However, advances have been made based on the results of recent research. Read More

J Investig Allergol Clin Immunol 2022 Jul 14. Epub 2022 Jul 14.

Department of Allergy, Hospital Clínic de Barcelona, University of Barcelona. Barcelona, Spain.

Nephron 2022 Jul 13:1-13. Epub 2022 Jul 13.

Nephrology, Hospital Universitario Fundación Alcorcón, Madrid, Spain.

Background: Acute interstitial nephritis (AIN) is one of the chief causes of acute kidney injury (AKI). AIN might be produced by drugs, infections, autoimmune diseases, or can be idiopathic. Among these etiologies, drug-induced AIN (DI-AIN) is the dominant one in many countries. Read More