29,915 results match your criteria Hypersensitivity Reactions Delayed


Allergy against Steroids in Ocular Inflammation.

Ocul Immunol Inflamm 2020 Jul 9:1-6. Epub 2020 Jul 9.

Research Group in Neurosciences NeURos. Escuela De Medicina Y Ciencias De La Salud, Universidad Del Rosario , Bogotá, Colombia.

Allergy to steroids is an uncommon and harmful condition that leads to a decrease in treatment options and increase in morbidity due to the suboptimal disease control. It can manifest as an immediate response or a delay manifestation. Worsening of underlying condition and not treatment response can indicate corticosteroids hypersensitivity as well. Read More

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http://dx.doi.org/10.1080/09273948.2020.1766511DOI Listing

Single-cell RNA analysis: guiding the treatment of DiHS/DRESS.

Allergy 2020 Jul 7. Epub 2020 Jul 7.

Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain.

Drug-induced hypersensitivity syndrome (DiHS) ─also termed as drug reaction with eosinophilia and systemic symptoms (DRESS)─ is a potentially lethal inflammatory disease associated with human herpesvirus (HHV) reactivation. DiHS/DRESS is classified within a group of syndromes named severe cutaneous adverse reactions (SCARs), including acute generalized exanthematous pustulosis and Stevens-Johnson syndrome/toxic epidermal necrolysis. SCARs are delayed type IV hypersensitivity reactions mainly characterized by T-cell activation. Read More

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http://dx.doi.org/10.1111/all.14487DOI Listing

Autism in Adulthood: Clinical and Demographic Characteristics of a Cohort of Five Hundred Persons with Autism Analyzed by a Novel Multistep Network Model.

Brain Sci 2020 Jul 1;10(7). Epub 2020 Jul 1.

Department of Health Sciences, Universita' del Piemonte Orientale, 28100 Novara, Italy.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in communication and relational skills, associated with repetitive verbal and motor behaviors, restricted patterns of interest, need for a predictable and stable environment, and hypo- or hypersensitivity to sensory inputs. Due to the challenging diagnosis and the paucity of specific interventions, persons with autism (PWA) reaching the adult age often display a severe functional regression. In this scenario, the Regional Center for Autism in Adulthood in Turin seeks to develop a personalized rehabilitation and enablement program for PWA who received a diagnosis of autism in childhood/adolescence or for individuals with suspected adulthood ASD. Read More

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http://dx.doi.org/10.3390/brainsci10070416DOI Listing

Sabra dermatitis: combined features of delayed hypersensitivity and foreign body reaction to implanted glochidia.

Dermatol Online J 2020 Apr 15;26(4). Epub 2020 Apr 15.

Weill Cornell Medicine, New York, NY.

A striking dermatitis referred to by its colloquial designation of sabra dermatitis is associated with glochidia inoculation from the Opuntia cactus commonly known as the prickly pear. We report a 45-year-old woman who had an unexpected encounter with a cactus plant during a trip to Texas. She brushed up against the plant and was aware that she had been inoculated with several spines of the plant. Read More

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Impaired Th1 response is associated therapeutic failure in patients with cutaneous leishmaniasis caused by Leishmania braziliensis.

J Infect Dis 2020 Jul 3. Epub 2020 Jul 3.

Instituto Gonçalo Moniz, FIOCRUZ, Salvador, Bahia, Brazil.

Background: Leishmania skin test (LST) evaluates the delayed type hypersensitivity to Leishmania antigens (LA) and has been used for diagnosis of cutaneous leishmaniasis (CL). CL patients usually present a positive LST, but as small percentage have a negative LST (LST-). The aim of this study was to determine the clinic and immunologic features and response to antimony therapy in LST- CL patients. Read More

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http://dx.doi.org/10.1093/infdis/jiaa374DOI Listing

Mechanistic insights into the anticandidal action of Vanillin reveal disruption of cell surface integrity and mitochondrial functioning.

Infect Disord Drug Targets 2020 Jul 2. Epub 2020 Jul 2.

Amity Institute of Biotechnology, Amity University Haryana, Gurugram (Manesar)-122413. India.

Background: Considering the emergence of multidrug resistance (MDR) in prevalent human fungal pathogen, Candida albicans, there is parallel spurt in development of novel strategies aimed to disrupt MDR. Compounds from natural resources could be exploited as efficient antifungal drugs owing to their structural diversity, cost effectiveness and negligible side effects.

Objective: The present study elucidates the antifungal mechanisms of Vanillin (Van), a natural food flavoring agent against Candida albicans. Read More

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http://dx.doi.org/10.2174/1871526520666200702134110DOI Listing

Study on immunoregulation function of peony seed proteolysis product in mice.

J Food Biochem 2020 Jul 2:e13353. Epub 2020 Jul 2.

College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, P.R. China.

To explore the immunoregulatory function of peony seed proteolysis product in mice, the protein from peony seed meal was extracted and hydrolyzed with bromelain. The peony seed proteolysis product was fed to mice at three different doses of 0.25, 0. Read More

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http://dx.doi.org/10.1111/jfbc.13353DOI Listing

Fingertip Injuries and Amputations: A Review of the Literature.

Cureus 2020 May 26;12(5):e8291. Epub 2020 May 26.

Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, USA.

The fingertip is defined as the part of the digit distal to the insertion of the extensor and flexor tendons on the distal phalanx. Devastating injuries to the hand occur every year that lead fingertip amputations in thousands of people. The highest incidence rates are usually seen in children less than five years old and in adults over the age of 65. Read More

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http://dx.doi.org/10.7759/cureus.8291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317129PMC

Increased severity of closed head injury or repetitive subconcussive head impacts enhances post-traumatic headache-like behaviors in a rat model.

Cephalalgia 2020 Jun 29:333102420937664. Epub 2020 Jun 29.

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Centre, Boston, MA, USA.

Introduction: Posttraumatic headache is one of the most common, debilitating, and difficult symptoms to manage after a traumatic head injury. The development of novel therapeutic approaches is nevertheless hampered by the paucity of preclinical models and poor understanding of the mechanisms underlying posttraumatic headache. To address these shortcomings, we previously characterized the development of posttraumatic headache-like pain behaviors in rats subjected to a single mild closed head injury using a 250 g weight drop. Read More

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http://dx.doi.org/10.1177/0333102420937664DOI Listing

Rising trends of symmetrical drug related intertriginous and flexural exanthem due to Itraconazole in patients with superficial dermatophytosis: A case series of 12 patients from eastern part of India.

Dermatol Ther 2020 Jun 28:e13911. Epub 2020 Jun 28.

Department of DVL, KPC Medical college and hospital, Kolkata, West Bengal, India.

SDRIFE(symmetrical drug related intertriginous and flexural exanthem) is a benign self limiting adverse drug reaction primarily affecting the intertriginous,gluteal and flexural regions symmetrically in the absence of systemic involvement.It is considered to be a variant of baboon syndrome.Pathogenesis is poorly understood but is thought to be result of a delayed hypersensitivity response after exposure to the drug. Read More

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http://dx.doi.org/10.1111/dth.13911DOI Listing

Immediate hypersensitivity reactions to steroids and steroid containing medications.

Curr Opin Allergy Clin Immunol 2020 Aug;20(4):362-366

Department of Respiratory Diagnostics and Bronchofiberoscopy, Medical University, Bialystok, Poland.

Purpose Of Review: Although rare and counterintuitive, hypersensitivity reactions to corticosteroids have been reported since the 1950s. Delayed hypersensitivity reactions following cutaneous exposure (contact allergy) are well understood and principles of testing, as well as cross-reactivity patterns, have been established. In contrast, understanding of immediate hypersensitivity reactions and delayed hypersensitivity reactions after systemic exposure is evolving more slowly. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000655DOI Listing

Delayed-type hypersensitivity to secukinumab with tolerance to ixekizumab.

J Allergy Clin Immunol Pract 2020 Jun 22. Epub 2020 Jun 22.

Department of Dermatology, Contact Allergy Unit, University Hospital Antwerp (UZA) and University of Antwerp (UA), Wilrijkstraat 10, B-2650 Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2020.06.016DOI Listing

Evaluation of T-Cell Responses Against Shared Melanoma Associated Antigens and Predicted Neoantigens in Cutaneous Melanoma Patients Treated With the CSF-470 Allogeneic Cell Vaccine Plus BCG and GM-CSF.

Front Immunol 2020 5;11:1147. Epub 2020 Jun 5.

Centro de Investigaciones Oncológicas, Fundación Cáncer, Buenos Aires, Argentina.

The CSF-470 vaccine consists of lethally-irradiated allogeneic cells derived from four cutaneous melanoma cell lines administered plus BCG and GM-CSF as adjuvants. In an adjuvant phase II study vs. IFN-α2b, the vaccine significantly prolonged the distant metastasis-free survival (DMFS) of stages IIB-IIC-III melanoma patients with evidence of the induction of immune responses against vaccine cells. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290006PMC

Age-at-onset-dependent effects of sulfur amino acid restriction on markers of growth and stress in male F344 rats.

Aging Cell 2020 Jun 22. Epub 2020 Jun 22.

Animal Science Laboratory, Orentreich Foundation for the Advancement of Science, NY, USA.

Trade-offs in life-history traits are clinically and mechanistically important. Sulfur amino acid restriction (SAAR) extends lifespan. But whether this benefit comes at the cost of other traits including stress resistance and growth is unclear. Read More

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http://dx.doi.org/10.1111/acel.13177DOI Listing

ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation.

Cell Mol Immunol 2020 Jun 22. Epub 2020 Jun 22.

Neuroinflammation Unit, Biotech Research & Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Ole Maaløes Vej 5, DK-2200, Copenhagen N, Denmark.

A disintegrin and metalloproteinase (ADAM)12 was previously found to be expressed in T cells in the inflamed brain. However, the function of ADAM12 in T-cell responses in general and in tissue inflammation has not been examined. Here, we studied the role of ADAM12 in T-cell responses, fate determination on activation, and its functions in T cells to mediate tissue inflammation. Read More

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http://dx.doi.org/10.1038/s41423-020-0486-8DOI Listing

and evaluation of the safety and efficacy of a novel liquid fiducial marker for image-guided radiotherapy.

Oncol Lett 2020 Jul 6;20(1):569-580. Epub 2020 May 6.

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China.

The true extent of a tumor is difficult to visualize, during radiotherapy, using current modalities. In the present study, the safety and feasibility of a mixture of N-butyl cyanoacrylate and lipiodol (NBCA/Lip) was evaluated in order to investigate the optimal combination for application as a fiducial marker for radiotherapy. Four combinations of NBCA/Lip injection (1:1-0. Read More

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http://dx.doi.org/10.3892/ol.2020.11591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286123PMC

Comparative evaluation of Mycobacterium avium subspecies paratuberculosis (MAP) recombinant secretory proteins as DTH marker for paratuberculosis.

J Microbiol Methods 2020 Jun 18;175:105987. Epub 2020 Jun 18.

Amity Center for Mycobacterial Disease Research, Amity University Rajasthan, Kant-Kalwar, Delhi-Jaipur Highway, NH11C, Jaipur 303 002, India. Electronic address:

Delayed type hypersensitivity (DTH) based skin test is an important onsite animal herd screening procedure for detecting the early stages of the chronic mycobacterial infections. DTH testing plays a vital role in the diagnosis of paratuberculosis infection. However, there are questions over the specificity of this test due to cross-reactive epitopes present on the purified protein derivative (PPD) prepared from the whole cell secretory proteins. Read More

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http://dx.doi.org/10.1016/j.mimet.2020.105987DOI Listing

Metamizole-induced reactions as a paradigm of drug hypersensitivity: Non-allergic reactions, anaphylaxis, and delayed-type allergy.

Clin Exp Allergy 2020 Jun 21. Epub 2020 Jun 21.

Department of Dermatology and Allergy, University Hospital Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1111/cea.13689DOI Listing

Epoetin-alfa induced pruritic maculopapular eruption: Case report and literature review.

Asian Pac J Allergy Immunol 2020 Jun 21. Epub 2020 Jun 21.

Division of Allergy Immunology and Rheumatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Erythropoiesis-stimulating agents (ESA) are commonly used in clinical practice to improve anaemia. Despite a number of patients successfully treated without adverse events, the complications have been previously reported.

Objective: To report and review the characteristics and management of ESA hypersensitivities. Read More

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http://dx.doi.org/10.12932/AP-040719-0592DOI Listing

Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy.

Cardiovasc Toxicol 2020 Jun 15. Epub 2020 Jun 15.

Department of Internal Medicine and Cardiology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.

The causes of nonischemic dilated cardiomyopathy are classified as genetic or nongenetic, but environmental factors such as metal pollutants may interact with genetic susceptibility. The presence of metal particles has been detected in the myocardium, including in those patients with dilated cardiomyopathy. It is also known that hypersensitivity reactions can induce inflammation in tissue. Read More

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http://dx.doi.org/10.1007/s12012-020-09582-6DOI Listing
June 2020
2.060 Impact Factor

A rare case of delayed hypersensitivity reaction to metal ions secondary to a remnant pedicle screw fragment after spinal arthrodesis.

Authors:
Jiha Kim

Acta Orthop Traumatol Turc 2020 Jun 18. Epub 2020 Jun 18.

Department of Neurosurgery, Kangwon National University, School of Medicine, Kangwon National University Hospital, Chuncheon-Si, Gangwon-Do, South Korea.

Delayed hypersensitivity reaction to metal ions is rare and has been mostly documented among patients undergoing total joint arthroplasty with metal-on-metal bearing surfaces. Nonetheless, to our knowledge, only a few cases associated with spinal arthrodesis have been reported in the literature. The aim of this case report was to describe the clinical features of a rare case of delayed-type hypersensitivity reaction to nickel that occurred after an extraordinarily long period of time (approximately 15 years) after spinal arthrodesis. Read More

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http://dx.doi.org/10.5152/j.aott.2020.20148DOI Listing

Alpha-gal syndrome: An emerging cause of food and drug allergy.

Clin Exp Allergy 2020 Jun 15. Epub 2020 Jun 15.

Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Bialystok, Poland.

Alpha-gal syndrome (AGS) describes a wide spectrum of hypersensitivity reactions mediated by specific IgE to the α-gal epitope (galactose-α-1,3-galactose) ubiquitously expressed on glycolipids/glycoproteins of most mammals. This fascinating new entity has completely changed the paradigms of allergy as allergic response is directed against an oligosaccharide and the reactions can be both immediate and delayed. They appear to be stimulated only by tick bites which induce production of α-gal specific IgE antibodies that lead to (at times fatal) hypersensitivity response. Read More

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http://dx.doi.org/10.1111/cea.13683DOI Listing

Topical antibiotics in the dermatological clinical practice: indications, efficacy and adverse effects.

Dermatol Ther 2020 Jun 12:e13824. Epub 2020 Jun 12.

Department of Biomedical Sciences and Human Oncology, Section of Dermatology, University of Bari, Bari, Italy.

Topical antibiotic therapy is a central component of patient management for several skin conditions, including acne, hidradenitis suppurativa, rosacea, impetigo or other superinfected dermatitis, prevention of wound infections. Moreover, particular situations, such as skin diseases of bacterial origin in pregnancy and infants often warrant topical therapy. However, the occurrence of local delayed hypersensitivity reactions and the rising rate of antibiotic resistance are becoming great challenges faced by many dermatologists today. Read More

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http://dx.doi.org/10.1111/dth.13824DOI Listing

Identification of PD1-mediated regulation of antitumor antigen response in patients with NSCLC using the trans vivo DTH assay.

J Immunother Cancer 2020 Jun;8(1)

Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA.

Objectives: Emerging evidence has shown a role for tumor antigen-specific regulation in cancer. Identifying individuals with pre-existing regulatory responses may be key to understand those who are more likely to respond to Programmed Death-1 (PD-1) or PD-1 Ligand 1 (PD-L1) checkpoint blockade. We hypothesized that a functional assay could identify the role of PD-1/PD-L1 interactions on tumor-specific immune cells in the peripheral blood in patients with advanced non-small-cell lung cancer (NSCLC). Read More

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http://dx.doi.org/10.1136/jitc-2019-000152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292037PMC

Hypersensitivity reaction of the gingiva to chlorhexidine: case report and literature review.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Jun 8. Epub 2020 Jun 8.

Department of Oral Medicine and Pathology, Faculty of Dentistry, National and Kapodistrian University of Athens, Greece. Electronic address:

Objective: The aim of this case report was to document a case of delayed-type hypersensitivity reaction of the gingiva to chlorhexidine and review the literature on oral mucosal hypersensitivity reactions associated to chlorhexidine-containing oral hygiene products.

Study Design: A 58-year-old man presented with a well-demarcated erythematous area on the right upper anterior gingiva. Incisional biopsy was performed. Read More

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http://dx.doi.org/10.1016/j.oooo.2020.04.814DOI Listing

T Helper 2 Inhibitors in Allergic Contact Dermatitis.

Dermatitis 2020 Jun 2. Epub 2020 Jun 2.

Division of Dermatology, Department of Medicine, University of Arizona, Tucson.

Clinical trials are currently underway to evaluate the benefit of dupilumab in treating allergic contact dermatitis (ACD). Dupilumab use has been reported to improve ACD reactions in some patients, but not all. Varying clinical responses to T helper 2 (TH2) inhibition challenge the classical view that ACD proceeds through a TH1-dominant pathway. Read More

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http://dx.doi.org/10.1097/DER.0000000000000616DOI Listing

Pain-related behaviors and abnormal cutaneous innervation in a murine model of classical Ehlers-Danlos syndrome.

Pain 2020 May 29. Epub 2020 May 29.

Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.

Classical Ehlers-Danlos syndrome (cEDS) is a connective tissue disorder caused by heterozygous mutations in one of the type V collagen-encoding genes, COL5A1 or COL5A2. cEDS is characterized by generalized joint hypermobility and instability, hyperextensible, fragile skin and delayed wound healing. Chronic pain is a major problem in cEDS patients, but the underlying mechanisms are largely unknown, and studies in animal models are lacking. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001935DOI Listing

Urticaria, Angioedema, and Anaphylaxis.

Pediatr Rev 2020 Jun;41(6):283-292

University of Rochester, Rochester, NY.

Urticaria and, to a lesser extent, angioedema are common occurrences in the pediatric population. There are multiple causes of acute and chronic urticaria and angioedema. Most causes are benign, although they can be worrisome for patients and their parents. Read More

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http://dx.doi.org/10.1542/pir.2019-0056DOI Listing

Detection of Abacavir-Induced Structural Alterations in Human Leukocyte Antigen-B*57 : 01 Using Phage Display.

Biol Pharm Bull 2020 ;43(6):1007-1015

Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University.

The interaction of human leukocyte antigen (HLA) with specific drugs is associated with delayed-type hypersensitivity reactions, which cause severe cutaneous toxicity. Such interactions induce structural alterations in HLA complexes via several different mechanisms such as the hapten theory, p-i concept, and altered peptide repertoire model, leading to the activation of cytotoxic T cells. To date, comprehensive detection of such structural alterations in preclinical studies has been difficult. Read More

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http://dx.doi.org/10.1248/bpb.b20-00102DOI Listing
January 2020

Orthopedic Implant Hypersensitivity Reactions: Concepts and Controversies.

Dermatol Clin 2020 Jul 25;38(3):361-369. Epub 2020 Apr 25.

Duke Dermatology, 5324 McFarland Road #210, Durham, NC 27707, USA. Electronic address:

Orthopedic implant hypersensitivity reactions (IHRs) are known to occur but are uncommon. Clinical presentations include local and generalized cutaneous reactions and noncutaneous complications. Pathogenesis traditionally was believed a type IV delayed hypersensitivity reaction, but there is evidence that innate immunity plays a role. Read More

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http://dx.doi.org/10.1016/j.det.2020.02.005DOI Listing

American Contact Dermatitis Society Allergens of the Year 2000 to 2020.

Dermatol Clin 2020 Jul 25;38(3):309-320. Epub 2020 Apr 25.

Department of Dermatology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA; Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, CO, USA. Electronic address:

Allergic contact dermatitis is a delayed type IV hypersensitivity skin reaction to external stimuli. Patterns of dermatitis depend on allergen exposure and patch testing is the gold standard to identify causal agents. The American Contact Dermatitis Society identifies an "Allergen of the Year" in order to highlight facts about particular allergens, which may range from showing increasing prevalence of disease, to documenting low levels of relevant allergic reactions. Read More

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http://dx.doi.org/10.1016/j.det.2020.02.011DOI Listing

The prevalence of hypersensitivity reactions to snake antivenoms administered in sultanah nur zahirah hospital from 2013 to 2016.

Med J Malaysia 2020 May;75(3):216-220

Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Department of Emergency Medicine, Cheras, Kuala Lumpur, Malaysia.

Introduction: Snakebite is an important medical emergency. Antivenoms remain the only proven treatment for snake envenoming. However, the use of antivenom is associated with hypersensitivity reactions. Read More

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Management Patterns of Delayed Inflammatory Reactions to Hyaluronic Acid Dermal Fillers: An Online Survey in Israel.

Clin Cosmet Investig Dermatol 2020 7;13:345-349. Epub 2020 May 7.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Over the past few decades, soft tissue augmentation is ever-increasing, specifically hyaluronic acid (HA)-based filler injections. As the number of these procedures have risen, so have the adverse reactions. Delayed-type inflammatory reactions (DIRs) secondary to tissue fillers are typically classified according to the time of appearance post-procedure and have various presentations including nodules, abscesses, edema, and discoloration. Read More

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http://dx.doi.org/10.2147/CCID.S247315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216297PMC

Reflux symptoms and oesophageal acidification in treated achalasia patients are often not reflux related.

Gut 2020 May 21. Epub 2020 May 21.

Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Objective: After treatment, achalasia patients often develop reflux symptoms. Aim of this case-control study was to investigate mechanisms underlying reflux symptoms in treated achalasia patients by analysing oesophageal function, acidification patterns and symptom perception.

Design: Forty treated achalasia patients (mean age 52. Read More

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http://dx.doi.org/10.1136/gutjnl-2020-320772DOI Listing

Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse.

Eur J Pharmacol 2020 Aug 11;880:173171. Epub 2020 May 11.

Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, USA.

Cathepsin S (CatS) is a cysteine protease found in lysosomes of hematopoietic and microglial cells and in secreted form in the extracellular space. While CatS has been shown to contribute significantly to neuropathic pain, the precise mechanisms remain unclear. In this report, we describe JNJ-39641160, a novel non-covalent, potent, selective and orally-available CatS inhibitor that is peripherally restricted (non-CNS penetrant) and may represent an innovative class of immunosuppressive and analgesic compounds and tools useful toward investigating peripheral mechanisms of CatS in neuropathic pain. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173171DOI Listing

New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control.

Parasite Epidemiol Control 2020 Aug 8;10:e00154. Epub 2020 May 8.

Parasitology Department, Evandro Chagas Institute, Ananindeua, Para State, Brazil.

The clinical-immunological spectrum of human -infection in Amazonian Brazil has recently been reviewed based on the combined use of the delayed-type hypersensitivity (DTH) and indirect fluorescence antibody test (IFAT-IgG/IgM), both with homologous -antigens, and associated with the clinical evaluation of infected individuals. This diagnostic approach has allowed to identify the broadest clinical-immunological spectrum of human -infection composed by five clinical-immunological profiles of infection: three asymptomatic, 1) Asymptomatic Infection (AI) [DTH, IFAT], 2) Subclinical Resistant Infection (SRI) [DTH, IFAT], and 3) Indeterminate Initial Infection (III) [DTH, IFAT], and two symptomatic ones, 4) Symptomatic Infection (SI) [=American visceral leishmaniasis - AVL] and, 5) Subclinical Oligosymptomatic Infection (SOI), both with the same immune profile [DTH, IFAT]. Herein, we confirm for the third time the preclinical diagnosis of AVL through IgM-antibody response in an early asymptomatic case of infection (profile III), a 17-year-old boy who evolved to AVL (=profile SI) six weeks after the initial infection diagnosis, confirming that the combined use of DTH and IFAT-(IgG/IgM) assays associated with the clinical evaluation of infected individuals is potentially useful for monitoring human -infection in endemic areas as well as optimizing AVL control. Read More

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http://dx.doi.org/10.1016/j.parepi.2020.e00154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232079PMC

Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability.

Pain 2020 May 13. Epub 2020 May 13.

Laboratory of Neuroimmunology, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

Understanding the mechanisms that drive transition from acute to chronic pain is essential to identify new therapeutic targets. The importance of endogenous resolution pathways acting as a "brake" to prevent development of chronic pain has been largely ignored. We examined the role of IL-10 in resolution of neuropathic pain induced by cisplatin. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001921DOI Listing

A possible case of serum sickness after ocrelizumab infusion - Commentary.

Mult Scler 2020 May 19:1352458520923947. Epub 2020 May 19.

Department of Neuroinflammation, Queen Square MS Centre, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK; NIHR UCLH Biomedical Research Centre, London, UK.

Serum sickness is a type III delayed hypersensitivity reaction which causes deposition of immune-complexes in the tissues. It has been reported with rituximab, and in this issue of the journal, there is a case report of a patient with relapsing remitting multiple sclerosis who developed a possible serum sickness after the third infusion of ocrelizumab. In this commentary, we discuss the current literature on serum sickness, and how to diagnose and manage it. Read More

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http://dx.doi.org/10.1177/1352458520923947DOI Listing

Evaluation of Subjects Experiencing Allergic Reactions to Non-Steroidal Anti-Inflammatory Drugs: Clinical Characteristics and Drugs Involved.

Front Pharmacol 2020 21;11:503. Epub 2020 Apr 21.

Allergy Unit, Malaga Regional University Hospital, Malaga, Spain.

Non-steroidal anti-inflammatory drugs (NSAIDs), the most commonly prescribed and consumed medicines worldwide, are the main triggers of drug hypersensitivity reactions (DHRs). The underlying mechanisms of NSAID-DHRs may be related to COX-1 inhibition (cross-hypersensitivity reactions, CRs) or to immunological recognition (selective reactions, SRs), being the latter remarkably less studied. SRs include those usually appearing within the first hour after drug intake (single-NSAID-induced urticaria/angioedema or anaphylaxis, SNIUAA), and those usually occurring more than 24 h after (single-NSAID-induced delayed reactions, SNIDR). Read More

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http://dx.doi.org/10.3389/fphar.2020.00503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212440PMC

Teicoplanin-induced immediate and delayed hypersensitivity reactions.

Ann Allergy Asthma Immunol 2020 May 13. Epub 2020 May 13.

Department of Allergy, Cambridge University Teaching Hospitals NHS Foundation Trust, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/j.anai.2020.05.006DOI Listing

An -based therapeutic vaccine for the treatment of papillomavirus-induced tumors.

J Virol 2020 May 13. Epub 2020 May 13.

University of Tuebingen, Interfaculty Institute for Cell Biology, Department of Immunology, Tuebingen, Germany

The Orf virus (ORFV) represents a suitable vector for the generation of efficient, prophylactic antiviral vaccines against different pathogens. The present study investigates for the first time the therapeutic application of ORFV vector-based vaccines against tumors induced by (CRPV). ORFV-CRPV recombinants were constructed expressing the early CRPV gene E1, E2, E7, or LE6, respectively. Read More

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http://dx.doi.org/10.1128/JVI.00398-20DOI Listing

Hot-Tub Lung Hypersensitivity Pneumonitis in a Greenhouse Worker.

Eur J Case Rep Intern Med 2020 20;7(5):001565. Epub 2020 Mar 20.

Internal Medicine Department, Hospital Santa Maria Maior, Barcelos, Portugal.

Hypersensitivity pneumonitis is understood to be a delayed allergic reaction to the repeated exposure of a usually innocent inhaled agent, causing inflammatory damage to the pulmonary parenchyma, alveoli and terminal bronchioles. With ongoing exposure, it can cause respiratory compromise and pulmonary fibrosis. Recognizing the heterogeneity of the causative agents and the low incidence of the disease, we considered it important to report the case of a greenhouse worker who developed a . Read More

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http://dx.doi.org/10.12890/2020_001565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213819PMC

Delayed hypersensitivity associated with amoxicillin-clavulanate.

Allergy 2020 May 10. Epub 2020 May 10.

Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, Vic, Australia.

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http://dx.doi.org/10.1111/all.14359DOI Listing

A case of delayed allergic reaction caused by local injection of triamcinolone acetonide.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Feb;45(2):216-220

Department of Periodontics & Oral Mucosal Section, Xiangya Stomatological Hospital & Xiangya School of Stomatology & Hunan Key Laboratory of Oral Health Research, Central South University, Changsha 410008, China

Glucocorticoid is a commonly used anti-inflammatory and anti-allergic drug in clinic. Allergic reactions caused by glucocorticoids are rare in clinic. Glucocorticoid allergy is a type of allergic reaction caused by glucocorticoid as an allergen, and its clinical manifestations of hypersensitivity are not specific. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2020.180584DOI Listing
February 2020

Orofacial pain secondary to acoustic neuroma-A case report.

Spec Care Dentist 2020 May 8;40(3):303-307. Epub 2020 May 8.

Department of Restorative Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.

Aim: The present study aimed to report a case of orofacial pain secondary to acoustic neuroma (AN).

Methods And Results: A 66-year-old female presented with unilateral facial pain and odontalgia. The pain was described as throbbing, dull, and constant. Read More

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http://dx.doi.org/10.1111/scd.12461DOI Listing