5,267 results match your criteria Hypersensitivity Pneumonitis


Clinical characteristics and outcomes of hypersensitivity pneumonitis: a population-based study in China.

Chin Med J (Engl) 2019 Apr 18. Epub 2019 Apr 18.

Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing, Jiangsu 210008, China.

Backgrounds: Hypersensitivity pneumonitis (HP) is an immune-mediated interstitial lung disease (ILD) that develops in response to the inhalation of various antigens. The clinical pathologies are very complex and undetermined. The clinical features and outcomes of HP have not been fully elucidated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CM9.0000000000000256DOI Listing

[Hypersensitivity pneumonitis in children].

Rev Mal Respir 2019 Apr 19. Epub 2019 Apr 19.

Service de pneumologie, hôpital Jean-Minjoz, CHU de Besançon, 25030 Besançon cedex, France; UMR CNRS 6249, Chrono-environnement, université de Franche-Comté, 25000 Besançon, France. Electronic address:

Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by an immune response to a variety of antigens to which patients have been previously sensitised. It can occur at any age. In children, it is a rare disease, probably under-diagnosed, with an estimated prevalence of 4 per million. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmr.2018.06.010DOI Listing

Does transbronchial lung cryobiopsy give useful information in asthmatic patients?

Multidiscip Respir Med 2019 8;14:12. Epub 2019 Apr 8.

Department of Thoracic Diseases, "GB. Morgagni" Hospital, Forlì, Italy.

Introduction: Lung biopsy in asthmatic patients is justified in case of atypical presentations of asthma, when other differential diagnoses, such as hypersensitivity pneumonitis or eosinophilic granulomatosis with polyangiitis, could be possible or for research purposes.

Aim: We aim to describe the utility and the safety of TBLC (transbronchial lung cryobiopsy) in asthmatic patients, providing data on the pathological changes occurring in the airways and in the lung parenchyma.

Methods: We reviewed asthmatic patients that underwent TBLC, that eventually had only a final diagnosis of asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40248-019-0176-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452509PMC
April 2019
1 Read

Obstructive sleep apnoea in patients with fibrotic diffuse parenchymal lung disease-characterization and treatment compliance assessment.

Can J Respir Ther 2018 1;54(2):35-40. Epub 2018 Aug 1.

Pulmonology Department, Centro Hospitalar São João, Oporto, Portugal.

Introduction: Recent studies have reported a high prevalence of obstructive sleep apnoea (OSA) among patients with diffuse parenchymal lung disease (DPLD), mainly idiopathic pulmonary fibrosis (IPF). Effective OSA treatment appears to have a positive impact on morbidity and mortality in these patients. However, poor compliance to positive airway pressure (PAP) treatment in fibrotic DPLD patients has been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29390/cjrt-2018-005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422053PMC
August 2018
1 Read

Hypersensitivity pneumonitis of a bagpipe player: Fungal antigens as trigger?

Med Mycol Case Rep 2019 Jun 26;24:44-47. Epub 2019 Mar 26.

Institute of Clinical Hygiene, Medical Microbiology and Infectiology, Paracelsus Medical University, Prof.-Ernst-Nathan Straße 1, 90419 Nuremberg, Germany.

Here we present a 79-year old man with chronic hypersensitivity pneumonitis probably caused by fungal contamination of a bagpipe. Several samples were taken from the patient's bagpipe. Four potential fungal antigens () as potential trigger of hypersensitivity pneumonitis were identified. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22117539193003
Publisher Site
http://dx.doi.org/10.1016/j.mmcr.2019.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447729PMC
June 2019
2 Reads

Forced Oscillation Technique and Small Airway Involvement in Chronic Hypersensitivity Pneumonitis.

Arch Bronconeumol 2019 Apr 8. Epub 2019 Apr 8.

Divisao de Pneumologia, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Objective: Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by the inhalation of specific organic antigens or low-molecular weight substances in genetically susceptible individuals. Although small airway involvement is prominent in patients with chronic HP, conventional pulmonary function tests (PFTs) are relatively insensitive to identify it. Thus, the authors aimed to evaluate resistance (R5) and reactance (X5) values at 5Hz on inspiration, expiration, and whole breath, as well as small airway resistance (R) values using a forced oscillation technique (FOT) in patients with chronic HP, and their responses after bronchodilator. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arbres.2019.01.022DOI Listing
April 2019
1 Read

Liver involvement in the drug reaction, eosinophilia, and systemic symptoms syndrome.

World J Clin Cases 2019 Mar;7(6):705-716

Department of Medicine, Division of Gastroenterology, University of Calgary, Calgary, Alberta T2N 4Z6, Canada.

First described in 1996, the drug reaction, eosinophilia, and systemic symptoms syndrome (DReSS) is considered, along with Stevens-Johnson syndrome and toxic epidermal necrolysis, a severe cutaneous drug reaction. It is characterized by the presence of a maculopapular erythematous skin eruption, fever, lymphadenopathy, influenza-like symptoms, eosinophilia, and visceral involvement such as hepatitis, pneumonitis, myocarditis, pericarditis, nephritis, and colitis. The prognosis of patients with DReSS is related to the severity of visceral involvement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12998/wjcc.v7.i6.705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448072PMC
March 2019
2 Reads

Hypersensitivity pneumonitis: A new strategy for serodiagnosis and environmental surveys.

Respir Med 2019 Apr 5;150:101-106. Epub 2019 Mar 5.

Department of Parasitology Mycology, University Hospital of Besançon, UMR/CNRS 6249 Chrono-Environnement Research Team, University of Bourgogne- Franche-Comté, France.

We propose a strategy for serodiagnosis of hypersensitivity pneumonitis (HP): 1) question patients about their private or occupational activity, or visit him on site; 2) select panels of six somatic specific antigens appropriate for each type of exposure; 3) and use ELISA to test concomitantly two recombinant antigens highly specific to Farmer's lung, Metalworking-fluid HP, and for Bird fancier's lung. The serodiagnosis provides an immunological argument that may complete radiological, functional lung exploration and clinical features; 4) If the serodiagnosis is negative but the suspicion of HP is strong, a microbial analysis of the patient's specific exposure is conducted; 5) "A la carte" antigens are produced from the microorganisms isolated in the patient's environment sample and tested; 6) Finally, the patient may be asked to undergo a specific inhalation challenge with the offending antigens in a safety cabin, or to avoid his usual environment for a few days. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09546111193006
Publisher Site
http://dx.doi.org/10.1016/j.rmed.2019.02.019DOI Listing
April 2019
2 Reads

Exacerbation of Previously Undiagnosed Bird Fancier's Lung by Pembrolizumab Therapy.

Chest 2019 Apr;155(4):e79-e82

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.

Immune checkpoint inhibitors have revolutionized cancer therapy. As the use of checkpoint inhibitors becomes widespread, the early recognition and treatment of their unique spectrum of adverse effects, called immune-related adverse events, become critical. Perhaps the most significant of these is the pulmonary toxicity currently described as "pneumonitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chest.2018.12.002DOI Listing
April 2019
2 Reads

CT Phenotypes in Hypersensitivity Pneumonitis.

Authors:
David A Lynch

Chest 2019 Apr;155(4):655-656

Department of Radiology, National Jewish Health, Denver, CO. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chest.2018.10.048DOI Listing
April 2019
2 Reads

Case 10-2019: A 69-Year-Old Man with Progressive Dyspnea.

N Engl J Med 2019 Mar;380(13):1268-1277

From the Departments of Medicine (K.E.B., S.B.M.), Radiology (J.F.F.), and Pathology (E.J.M.), Massachusetts General Hospital, and the Departments of Medicine (K.E.B., S.B.M.), Radiology (J.F.F.), and Pathology (E.J.M.), Harvard Medical School - both in Boston.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMcpc1900143DOI Listing
March 2019
2 Reads

Bronchoalveolar lavage cell profiles and proteins concentrations can be used to phenotype extrinsic allergic alveolitis patients.

Multidiscip Respir Med 2019 12;14:13. Epub 2019 Mar 12.

1Department of Respiratory Medicine, Thomayer Hospital, Videnska 800, 140 00 Prague 4, Czech Republic.

Background: Extrinsic allergic alveolitis (EAA) patients form heterogenous group with different clinical manifestation and different prognosis. We aimed to determine how to phenotype distinct EAA subgroups. Predictive role of the bronchoalveolar lavage fluid (BALF) IL-4Rα concentration at the time of diagnosis with regard to the clinical behavior in EAA patients was studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40248-019-0175-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413447PMC
March 2019
1 Read

Video-assisted thoracic surgery ultrasound (VATS-US) in the evaluation of subpleural disease: preliminary report of a systematic study.

J Ultrasound 2019 Mar 23. Epub 2019 Mar 23.

Department of Internal Medicine and Medical Disciplines, Sapienza University of Rome, Rome, Italy.

We provide a pictorial essay examining the preliminary data of an ongoing study whose primary aim is to assess the usefulness and safety of video-assisted thoracic surgery ultrasound (VATS-US) in the identification of different lung diseases. We studied 14 patients (five women and nine men with a mean age of 56.2 ± 8. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40477-019-00374-5DOI Listing
March 2019
1 Read

[Chronic fibrosing lung diseases : Idiopathic pulmonary fibrosis from the perspective of its differential diagnosis].

Internist (Berl) 2019 Apr;60(4):345-361

Abteilung für Innere Medizin, Justus-Liebig-Universität Gießen, Gießen, Deutschland.

Fibrosing lung diseases describe a heterogeneous group of interstitial lung diseases (ILD) of highly variable etiology, but with a unifying terminal process of irreversible, fibroproliterative destruction of the alveolar surface, loss of compliance and progressive impairment of gas exchange. In view of the heterogeneity, the disastrous prognoses in some cases and the treatment consequences, a thorough differential diagnosis is essential in all patients. Antifibrotic therapies are currently only indicated in idiopathic pulmonary fibrosis (IPF). Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00108-019-0571-1
Publisher Site
http://dx.doi.org/10.1007/s00108-019-0571-1DOI Listing
April 2019
3 Reads

Predictive factors of obstructive sleep apnoea in patients with fibrotic lung diseases.

Sleep Med 2019 Jan 26. Epub 2019 Jan 26.

Department of Pneumology of São João Hospital Center, Oporto, Portugal; Respiratory Sleep Disorders Unit, Department of Pneumology of São João Hospital Center, Oporto, Portugal.

Background And Aim: Several studies reported a high prevalence of Obstructive Sleep Apnoea (OSA) in patients with Idiopathic Pulmonary Fibrosis (IPF) or restrictive end-stage lung disease (ESLD). Besides the known risk factors for OSA like high Body Mass Index (BMI), reduced static and dynamic volumes for IPF patients and reduced DLCO and low minimal O saturation during sleep for ESLD patients were associated with higher Apnoea-Hypopnoea Index (AHI). The aim of our study was to determine potential predictive factors of OSA in patients with Fibrotic Lung Diseases (FLD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sleep.2019.01.020DOI Listing
January 2019
1 Read

Periostin as a predictor of prognosis in chronic bird-related hypersensitivity pneumonitis.

Allergol Int 2019 Mar 11. Epub 2019 Mar 11.

Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

Background: Periostin is an established biomarker of Th2 immune response and fibrogenesis. Recent research has indicated that periostin plays an important role in the pathogenesis of idiopathic interstitial pneumonias. To clarify the relationship between periostin and pathogenesis in chronic bird-related hypersensitivity pneumonitis (HP) and to reveal the usefulness of serum periostin levels in diagnosing and managing chronic bird-related HP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2019.02.007DOI Listing
March 2019
2 Reads

The natural history of progressive fibrosing interstitial lung diseases.

Respir Res 2019 Mar 14;20(1):57. Epub 2019 Mar 14.

Department of Respiratory Medicine, Thomayer Hospital, Videnska 800, 14059, Prague, Czech Republic.

A proportion of patients with certain types of interstitial lung disease (ILD), including chronic hypersensitivity pneumonitis and ILDs associated with autoimmune diseases, develop a progressive fibrosing phenotype that shows similarities in clinical course to idiopathic pulmonary fibrosis. Irrespective of the clinical diagnosis, these progressive fibrosing ILDs show commonalities in the underlying pathogenetic mechanisms that drive a self-sustaining process of pulmonary fibrosis. The natural history of progressive fibrosing ILDs is characterized by decline in lung function, worsening of symptoms and health-related quality of life, and early mortality. Read More

View Article

Download full-text PDF

Source
https://respiratory-research.biomedcentral.com/articles/10.1
Publisher Site
http://dx.doi.org/10.1186/s12931-019-1022-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417262PMC
March 2019
9 Reads

Transbronchial cryobiopsy in fibrosing interstitial lung disease: modifications of the procedure lead to risk reduction.

Thorax 2019 Mar 9. Epub 2019 Mar 9.

Clinic for Pneumology and Allergology, Center of Sleep Medicine and Respiratory Care, Hospital Bethanien Solingen, Solingen, Germany.

Sixty-one subjects with fibrosing interstitial lung disease were prospectively analysed to determine the efficacy of transbronchial cryobiopsy (CryoTBB) and the effect of procedural modifications which were introduced after an interim analysis of the first 19 subjects. The modifications significantly reduced complication rates from 84% to 14% (p<0.001). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/thoraxjnl-2018-212095DOI Listing
March 2019
2 Reads

In vivo probe-based confocal laser endomicroscopy in chronic interstitial lung diseases: Specific descriptors and correlation with chest CT.

Respirology 2019 Feb 27. Epub 2019 Feb 27.

Normandie Université, UNIROUEN, Rouen, France.

Background And Objective: Probe-based confocal laser endomicroscopy (pCLE) enables in vivo microimaging of the distal lung, during bronchoscopy. This study aims at identifying pCLE descriptors of chronic interstitial lung diseases (ILD), their correlations with chest HRCT and assessing inter-observer agreement.

Methods: pCLE was performed in 21 healthy volunteers (HV) and 59 non-smoking ILD patients, including 19 patients with idiopathic pulmonary fibrosis (IPF) or asbestosis, 15 with connective tissue disease-associated ILD (CTD-ILD), 17 with sarcoidosis and 8 with hypersensitivity pneumonitis (HP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/resp.13507DOI Listing
February 2019
3 Reads

Therapeutic burden in interstitial lung disease: Lessons to learn.

Respirology 2019 Feb 20. Epub 2019 Feb 20.

Department of Respiratory and Sleep Medicine, Austin Health, Melbourne, VIC, Australia.

Background And Objective: Patients with interstitial lung disease (ILD) are often prescribed disease-targeted and symptomatic therapies, both of which can cause significant treatment burden due to polypharmacy and drug-disease interactions. This study aimed to evaluate medication regimen complexity before and after introduction of ILD-specific therapies. Potential drug-disease interactions were evaluated for patients who were prescribed prednisolone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/resp.13480DOI Listing
February 2019
2 Reads

Specific Serum Immunoglobulin G (IgG) Levels Against Antigens Implicated in Hypersensitivity Pneumonitis in Asymptomatic Individuals.

Ann Acad Med Singapore 2019 Jan;48(1):36-38

Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.

View Article

Download full-text PDF

Source
January 2019

Increasing Hypersensitivity Pneumonitis-Related Mortality in the United States from 1988 to 2016.

Am J Respir Crit Care Med 2019 Feb 15. Epub 2019 Feb 15.

National Jewish Health, Pulmonary, Critical Care and Sleep Medicine, Denver, Colorado, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201807-1258LEDOI Listing
February 2019
4 Reads

NK and NKT cells in the diagnosis of diffuse lung diseases presenting with a lymphocytic alveolitis.

BMC Pulm Med 2019 Feb 13;19(1):39. Epub 2019 Feb 13.

Department of Pulmonology, Hospital de São João and Faculty of Medicine, University of Porto, Porto, Portugal.

Background: Diffuse lung diseases (DLD) are characterized by different immunophenotypes in the bronchoalveolar lavage fluid (BALF). We aimed to evaluate the diagnostic value of BALF NK and NKT cell counts of patients with DLD and lymphocytic alveolitis.

Methods: We assessed 202 patients with DLD, who underwent BALF immunophenotyping. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0802-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373142PMC
February 2019
2 Reads

'When you hear hooves, think zebras, not horses'; two challenging cases of interstitial lung disease (ILD).

BMJ Case Rep 2019 Feb 11;12(2). Epub 2019 Feb 11.

Department of Respiratory Medicine, St Vincent's University Hospital, Dublin, Ireland.

Our case series describes two siblings with complex fibrosing lung diseases. The first patient was initially given a diagnosis of sarcoidosis based on imaging and exclusion of alternative diagnoses. A number of years after diagnosis, he had rapid deterioration of his disease and following surgical lung biopsy, his lung fibrosis was re-classified as chronic hypersensitivity pneumonitis (cHP) with a usual interstitial pneumonia pattern. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-224507DOI Listing
February 2019
13 Reads

Hypersensitivity reaction with multi-organ failure following re-exposure to rifampicin: case report and review of the literature including WHO spontaneous safety reports.

BMC Pharmacol Toxicol 2019 Feb 12;20(1). Epub 2019 Feb 12.

Department of Clinical Pharmacology & Toxicology, University Hospital Basel, Basel, Switzerland.

Background: True hypersensitivity reactions to rifampicin are relatively rare, nonetheless severe manifestations mostly involving a single organ have been documented. We report a case of acute multi-organ failure occurring after a medication error with re-exposure to rifampicin.

Case Presentation: A 68-year old patient developed acute hypersensitivity pneumonitis, acute renal failure, acute liver failure and haemolytic anemia within hours after a second re-exposure to Rifampicin for the treatment of a hip prosthesis infection with Staphylococcus epidermidis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40360-019-0289-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373162PMC
February 2019
2 Reads

Diagnostics and acknowledgement of occupational diseases - topics and challenges in the Czech Republic.

Cas Lek Cesk 2018 Dec;157(8):396-399

The causes of occupational diseases are changing, thats why a regular update of Czech List of Occupational Diseases is needed. New compensable occupational diseases, such as cancer of the larynx and ovarian cancer due to asbestos, and chronic obstructive pulmonary diseases due to black coal dust were included in the last two updates of the Czech List. The need of an early examination at the Centers of Occupational Diseases is stressed in this article, especially before a surgery or other treatment of epicondylitis and carpal tunnel syndrome. Read More

View Article

Download full-text PDF

Source
December 2018
1 Read

Interstitial Lung Diseases in Developing Countries.

Ann Glob Health 2019 Jan 22;85(1). Epub 2019 Jan 22.

Interstitial Lung Disease Unit, Pulmonology Service, Bellvitge University Hospital. Instituto de Investigación Biomédica de Bellvitge (IDIBELL).

More than 100 different conditions are grouped under the term interstitial lung disease (ILD). A diagnosis of an ILD primarily relies on a combination of clinical, radiological, and pathological criteria, which should be evaluated by a multidisciplinary team of specialists. Multiple factors, such as environmental and occupational exposures, infections, drugs, radiation, and genetic predisposition have been implicated in the pathogenesis of these conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5334/aogh.2414DOI Listing
January 2019
6 Reads

Acute inflammatory and immunologic responses against antigen in chronic bird-related hypersensitivity pneumonitis.

Allergol Int 2019 Feb 5. Epub 2019 Feb 5.

Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:

Background: Hypersensitivity pneumonitis (HP) is an immune-mediated lung disease induced by the inhalation of a wide variety of antigens and a persistent antigen exposure induces inevitably pulmonary fibrosis in chronic HP. Although neutrophils, Th1 and Th17 cells contribute to lung inflammation in acute phase of HP, there is no clear explanation as to how the immunological reaction occurs just after the inhalation of causative antigens in the chronic phase of HP.

Methods: We examined the inflammatory and immunologic profiles before and after the inhalation provocation test (IPT) in serum and bronchoalveolar lavage fluid (BALF) from patients with chronic bird-related HP (BRHP) and other interstitial lung diseases (ILDs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.12.010DOI Listing
February 2019
2 Reads

Imaging in idiopathic pulmonary fibrosis: diagnosis and mimics.

Clinics (Sao Paulo) 2019 02 4;74:e225. Epub 2019 Feb 4.

Divisao Pulmonar, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Idiopathic pulmonary fibrosis is a chronic disease of unknown etiology that usually has a progressive course and is commonly associated with a poor prognosis. The main symptoms of idiopathic pulmonary fibrosis, including progressive dyspnea and dry cough, are often nonspecific. Chest high-resolution computed tomography is the primary modality used in the initial assessment of patients with suspected idiopathic pulmonary fibrosis and may have considerable influence on subsequent management decisions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.6061/clinics/2019/e225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384526PMC
February 2019
3 Reads

Major Depressive Disorder in Medical Illness: A Review of Assessment, Prevalence, and Treatment Options.

Psychosom Med 2019 Apr;81(3):246-255

From the Department of Psychiatry (Thom, Silbersweig, Boland), Brigham and Women's Hospital; and Harvard Medical School (Thom, Silbersweig, Boland), Boston, Massachusetts.

Major depression, as well as other depressive disorders, is commonly comorbid with other medical illnesses, particularly chronic and systemic medical illnesses. The co-occurrence of the disorders is so common that it challenges our notions of the meaning of comorbidity and our desire to neatly separate psychiatric and medical illnesses. The overlap between symptoms of physical illness and the neurovegetative symptoms of major depression and the initial normative emotional response to physical illness add to the challenge of accurate diagnosis and timely treatment of depression in the medically ill. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PSY.0000000000000678DOI Listing
April 2019
22 Reads

Hypersensitivity Pneumonitis.

Semin Roentgenol 2019 Jan 27;54(1):37-43. Epub 2018 Dec 27.

Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.ro.2018.12.004DOI Listing
January 2019
3 Reads

Integrating Genomics Into Management of Fibrotic Interstitial Lung Disease.

Chest 2019 Jan 17. Epub 2019 Jan 17.

Division of Pulmonary & Critical Care & Sleep Medicine (Dr Noth), Department of Medicine, University of Virginia, Charlottesville, VA.

Fibrotic interstitial lung diseases (ILDs) have a high mortality rate with an unpredictable disease course and clinical features that frequently overlap. Recent data indicate important roles for genomics in the mechanisms underlying susceptibility and progression of pulmonary fibrosis. The impact of these genomic markers on pharmacotherapy and their contribution to outcomes is increasingly recognized. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00123692193000
Publisher Site
http://dx.doi.org/10.1016/j.chest.2018.12.011DOI Listing
January 2019
19 Reads

Clinical Characteristics and Etiologies of Miliary Nodules in the US: A Single-Center Study.

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine. Electronic address:

Background: Miliary nodules have been typically described as a radiological manifestation of disseminated tuberculosis. However, miliary nodules are known to occur in a wide variety of conditions. The primary objective of the study was to identify clinical characteristics and etiologies of miliary nodules within our institution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjmed.2018.12.030DOI Listing
January 2019
4 Reads

CT Honeycombing Identifies a Progressive Fibrotic Phenotype with Increased Mortality Across Diverse Interstitial Lung Diseases.

Ann Am Thorac Soc 2019 Jan 17. Epub 2019 Jan 17.

University of Chicago, Radiology, Chicago, Illinois, United States.

Rationale: Honeycombing on chest computed tomography (CT) has been described in diverse forms of interstitial lung disease (ILD), however, its prevalence and association with mortality across the spectrum of ILD remains unclear.

Objective: To determine the prevalence and prognostic value of CT honeycombing and characterize associated mortality patterns across diverse ILD subtypes in a multicenter cohort.

Methods: Observational cohort study of adult participants with multidisciplinary or adjudicated ILD diagnosis and documentation of chest CT imaging at index diagnosis across five US hospitals (one tertiary and four non-tertiary medical centers). Read More

View Article

Download full-text PDF

Source
https://www.atsjournals.org/doi/10.1513/AnnalsATS.201807-443
Publisher Site
http://dx.doi.org/10.1513/AnnalsATS.201807-443OCDOI Listing
January 2019
21 Reads

Musical instruments, fungal spores and hypersensitivity pneumonitis.

QJM 2019 Apr;112(4):287-289

North Bristol Lung Centre, Southmead Hospital, Westbury-on-Trym, Bristol, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/qjmed/hcz020DOI Listing
April 2019
4 Reads

Diagnosis of occupational hypersensitivity pneumonitis.

Curr Opin Allergy Clin Immunol 2019 Apr;19(2):105-110

Vall d'Hebron Institut de Recerca (VHIR).

Purpose Of Review: To discuss the diagnostic methods currently used in the study of patients with hypersensitivity pneumonitis, with special emphasis on the most recent contributions published in the medical literature regarding the diagnosis of occupational hypersensitivity pneumonitis (OHP). This review presents an update of the use of these diagnostic tests, a controversial issue among experts.

Recent Findings: In spite of the multiple attempts at systematization and the publication of expert consensus statements, standardizing and diagnostic methods and criteria remain particularly difficult. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00130832-900000000-9918
Publisher Site
http://dx.doi.org/10.1097/ACI.0000000000000511DOI Listing
April 2019
7 Reads

Concomitant hypersensitivity pneumonitis and occupational asthma caused by 2 different etiologic agents.

Ann Allergy Asthma Immunol 2019 Apr 12;122(4):424-425.e1. Epub 2019 Jan 12.

Servicio de Neumología Hospital Universitario Vall d'Hebron, Barcelona, Spain; Centro de Investigación en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Department of Cell Biology, Physiology, and Immunology, Universitat Autònoma de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anai.2019.01.007DOI Listing
April 2019
2 Reads

Bronchoscopic lung cryobiopsy: An Indian association for bronchology position statement.

Lung India 2019 Jan-Feb;36(1):48-59

Department of Pulmonary Medicine, Christian Medical College, Vellore, India.

Background: Bronchoscopic lung cryobiopsy (BLC) is a novel technique for obtaining lung tissue for the diagnosis of diffuse parenchymal lung diseases. The procedure is performed using several different variations of technique, resulting in an inconsistent diagnostic yield and a variable risk of complications. There is an unmet need for standardization of the technical aspects of BLC. Read More

View Article

Download full-text PDF

Source
http://www.lungindia.com/text.asp?2019/36/1/48/249179
Publisher Site
http://dx.doi.org/10.4103/lungindia.lungindia_75_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330795PMC
January 2019
23 Reads

Influence of chlorinated water on the development of allergic diseases - An overview.

Ann Agric Environ Med 2018 Dec 10;25(4):651-655. Epub 2018 Jan 10.

Department of Gastroenterology, Metabolic and Internal Diseases and Dietetics, Poznań, Poland.

Indoor swimming pools can be used all year round and serve for one of the most popular sport pursued for recreation. The positive effect of swimming arises in particular from the involvement of all the muscles of the body, decreasing the burden on the joints, as well as functional improvement of both the lungs and heart. Chlorine is typically used to disinfect swimming pool water and as a result the changes that take place lead to the formation of by-products, such as monochloramines (NH2Cl), dichloramines (NH2Cl2) i trichloramines (NH2Cl3), trihalogenometans (THM) or haloacetic acid (HAA). Read More

View Article

Download full-text PDF

Source
http://www.journalssystem.com/aaem/Influence-of-chlorinated-
Publisher Site
http://dx.doi.org/10.26444/aaem/79810DOI Listing
December 2018
10 Reads

Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung diseases.

Eur Respir Rev 2018 Dec 21;27(150). Epub 2018 Dec 21.

Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK.

Although these conditions are rare, a proportion of patients with interstitial lung diseases (ILDs) may develop a progressive-fibrosing phenotype. Progressive fibrosis is associated with worsening respiratory symptoms, lung function decline, limited response to immunomodulatory therapies, decreased quality of life and, potentially, early death. Idiopathic pulmonary fibrosis may be regarded as a model for other progressive-fibrosing ILDs. Read More

View Article

Download full-text PDF

Source
http://err.ersjournals.com/lookup/doi/10.1183/16000617.0076-
Publisher Site
http://dx.doi.org/10.1183/16000617.0076-2018DOI Listing
December 2018
23 Reads

Pharmacological management of progressive-fibrosing interstitial lung diseases: a review of the current evidence.

Eur Respir Rev 2018 Dec 21;27(150). Epub 2018 Dec 21.

Pulmonary Medicine, Cetrángolo Hospital, Buenos Aires, Argentina.

A proportion of patients with interstitial lung diseases (ILDs) are at risk of developing a progressive-fibrosing phenotype, which is associated with a deterioration in lung function and early mortality. In addition to idiopathic pulmonary fibrosis (IPF), fibrosing ILDs that may present a progressive phenotype include idiopathic nonspecific interstitial pneumonia, connective tissue disease-associated ILDs, hypersensitivity pneumonitis, unclassifiable idiopathic interstitial pneumonia, ILDs related to other occupational exposures and sarcoidosis. Corticosteroids and/or immunosuppressive therapies are sometimes prescribed to patients with these diseases. Read More

View Article

Download full-text PDF

Source
http://err.ersjournals.com/lookup/doi/10.1183/16000617.0074-
Publisher Site
http://dx.doi.org/10.1183/16000617.0074-2018DOI Listing
December 2018
20 Reads

Effects of Corticosteroid Treatment and Antigen Avoidance in a Large Hypersensitivity Pneumonitis Cohort: A Single-Centre Cohort Study.

J Clin Med 2018 Dec 21;8(1). Epub 2018 Dec 21.

Department of Respiratory Diseases, Unit for interstitial lung diseases, University Hospitals Leuven, Leuven B-3000, Belgium.

Background: Although the third most frequent interstitial lung disease, hypersensitivity pneumonitis (HP) remains an enigmatic disease without clear diagnostic and therapeutic guidelines. We assessed the effect of the commonly used therapeutic interventions (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm8010014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352061PMC
December 2018
3 Reads

[Hypersensitivity pneumonitis and abscess reaction to nontuberculous mycobacteria acquired form jacuzzi aerosol].

Rev Mal Respir 2019 Jan 17;36(1):57-62. Epub 2018 Dec 17.

Université François Rabelais, Inserm U1100, faculté de médecine de Tours, 37000 Tours, France.

Introduction: Mycobacterium avium complex can be responsible for a number of different radio-clinical presentations, ranging from invasive infections to hypersensitivity pneumonitis due to repeated inhalation of antigens. The diagnosis of hypersensitivity pneumonitis is clinical, radiological, biological and microbiological.

Case Report: A 61-year-old male developed a hypersensitivity pneumonitis reaction to non-tuberculous mycobacteria, following the repeated use of his own spa, which later evolved into chronic respiratory failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmr.2017.10.670DOI Listing
January 2019
2 Reads

The Analysis of Surgical Lung Biopsy and Explanted Lung Specimens Sheds Light on the Pathological Progression of Chronic Bird-related Hypersensitivity Pneumonitis.

Intern Med 2019 Apr 18;58(8):1145-1150. Epub 2018 Dec 18.

Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.

Chronic hypersensitivity pneumonitis is an interstitial pneumonia caused by an immunological reaction to the chronic inhalation of an antigen. Little is known, however, about the pathological change of the pulmonary lesions. A 33-year-old man was diagnosed with chronic bird-related hypersensitivity pneumonitis based on the findings of a surgical lung biopsy and an inhalation provocation test. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2169/internalmedicine.1142-18DOI Listing
April 2019
3 Reads

Pulmonary Veno-occlusive Disease: A Surgical Lung Biopsy-proven and Autopsied Case Radiologically Mimicking Hypersensitivity Pneumonitis at the Time of a Transbronchial Lung Biopsy.

Intern Med 2019 Apr 18;58(7):955-964. Epub 2018 Dec 18.

Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.

Pulmonary veno-occlusive disease (PVOD) is a rare disease in the subgroup of conditions known as pulmonary arterial hypertension. Although a histological examination is needed for a definitive diagnosis, a non-invasive diagnosis is required for patients with pulmonary hypertension because a lung biopsy is deemed risky. We herein report a 32-year-old woman diagnosed with PVOD via a surgical lung biopsy and autopsy whose disease showed radiological findings mimicking those of hypersensitivity pneumonitis (pneumonia) at the time of the transbronchial lung biopsy, without obvious pulmonary hypertension on admission. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2169/internalmedicine.0681-17DOI Listing
April 2019
2 Reads

Role of Antigen Type in Survival in Chronic Hypersensitivity Pneumonitis.

Lung 2019 Feb 14;197(1):113-114. Epub 2018 Dec 14.

Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75219, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00408-018-0187-6DOI Listing
February 2019
3 Reads

Association of Noninfectious Pneumonia With Ustekinumab Use.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Office of Surveillance and Epidemiology, Division of Pharmacovigilance, FDA Center for Drug Evaluation and Research, Silver Spring, Maryland.

Importance: The US Food and Drug Administration (FDA) conducts ongoing public health safety surveillance for drug and therapeutic biologic products. Identifying cases of acute and subacute noninfectious pneumonia supports the public health mission of the FDA.

Objective: To identify and analyze postmarketing cases of noninfectious pneumonia associated with ustekinumab use. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamadermatol.2018.4118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439534PMC
December 2018
3 Reads

Immune-Related Adverse Events: Pneumonitis.

Adv Exp Med Biol 2018;995:131-149

Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Checkpoint inhibitors are part of the family of immunotherapies and are increasingly being used in a wide variety of cancers. Immune-related adverse events pose a major challenge in the treatment of cancer patients. Pneumonitis is a rare immune-related adverse event that presents in distinct patterns. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-030-02505-2_6DOI Listing
January 2018

Second Hypersensitivity Pneumonitis in the Same Patient Caused by Chinchillas.

J Investig Allergol Clin Immunol 2018 Dec;28(6):441-442

Department of Respiratory Diseases, University Hospital of Besançon, Besançon, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18176/jiaci.0319DOI Listing
December 2018
2 Reads

Long-term outcomes in chronic hypersensitivity pneumonitis.

Allergy 2018 Dec 4. Epub 2018 Dec 4.

Servicio de Neumología, Departamento de Medicina, Hospital Universitario Vall d'Hebron, Universidad Autónoma de Barcelona, Barcelona, Cataluña, España.

Introduction: The objective of this study was to analyze mortality, possible predictors of long-term survival, and health-related quality of life of a large chronic hypersensitivity pneumonitis (CHP) patient sample.

Methods: Longitudinal study in patients diagnosed with CHP during 2004-2013, followed for at least 1 year. Patients remaining alive and consenting to participate had a follow-up visit during 2015, including a complete pulmonary function study and the EuroQol-5D and Beck Depression and Anxiety Inventories. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/all.13692
Publisher Site
http://dx.doi.org/10.1111/all.13692DOI Listing
December 2018
23 Reads