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Am J Respir Crit Care Med 2019 Feb 15. Epub 2019 Feb 15.

National Jewish Health, Pulmonary, Critical Care and Sleep Medicine, Denver, Colorado, United States.

BMC Pulm Med 2019 Feb 13;19(1):39. Epub 2019 Feb 13.

Department of Pulmonology, Hospital de São João and Faculty of Medicine, University of Porto, Porto, Portugal.

Background: Diffuse lung diseases (DLD) are characterized by different immunophenotypes in the bronchoalveolar lavage fluid (BALF). We aimed to evaluate the diagnostic value of BALF NK and NKT cell counts of patients with DLD and lymphocytic alveolitis.

Methods: We assessed 202 patients with DLD, who underwent BALF immunophenotyping. Read More

BMJ Case Rep 2019 Feb 11;12(2). Epub 2019 Feb 11.

Department of Respiratory Medicine, St Vincent's University Hospital, Dublin, Ireland.

Our case series describes two siblings with complex fibrosing lung diseases. The first patient was initially given a diagnosis of sarcoidosis based on imaging and exclusion of alternative diagnoses. A number of years after diagnosis, he had rapid deterioration of his disease and following surgical lung biopsy, his lung fibrosis was re-classified as chronic hypersensitivity pneumonitis (cHP) with a usual interstitial pneumonia pattern. Read More

BMC Pharmacol Toxicol 2019 Feb 12;20(1). Epub 2019 Feb 12.

Department of Clinical Pharmacology & Toxicology, University Hospital Basel, Basel, Switzerland.

Background: True hypersensitivity reactions to rifampicin are relatively rare, nonetheless severe manifestations mostly involving a single organ have been documented. We report a case of acute multi-organ failure occurring after a medication error with re-exposure to rifampicin.

Case Presentation: A 68-year old patient developed acute hypersensitivity pneumonitis, acute renal failure, acute liver failure and haemolytic anemia within hours after a second re-exposure to Rifampicin for the treatment of a hip prosthesis infection with Staphylococcus epidermidis. Read More

Cas Lek Cesk 2019 ;157(8):396-399

The causes of occupational diseases are changing, thats why a regular update of Czech List of Occupational Diseases is needed. New compensable occupational diseases, such as cancer of the larynx and ovarian cancer due to asbestos, and chronic obstructive pulmonary diseases due to black coal dust were included in the last two updates of the Czech List. The need of an early examination at the Centers of Occupational Diseases is stressed in this article, especially before a surgery or other treatment of epicondylitis and carpal tunnel syndrome. Read More

Ann Glob Health 2019 Jan 22;85(1). Epub 2019 Jan 22.

Interstitial Lung Disease Unit, Pulmonology Service, Bellvitge University Hospital. Instituto de Investigación Biomédica de Bellvitge (IDIBELL).

More than 100 different conditions are grouped under the term interstitial lung disease (ILD). A diagnosis of an ILD primarily relies on a combination of clinical, radiological, and pathological criteria, which should be evaluated by a multidisciplinary team of specialists. Multiple factors, such as environmental and occupational exposures, infections, drugs, radiation, and genetic predisposition have been implicated in the pathogenesis of these conditions. Read More

Allergol Int 2019 Feb 5. Epub 2019 Feb 5.

Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:

Background: Hypersensitivity pneumonitis (HP) is an immune-mediated lung disease induced by the inhalation of a wide variety of antigens and a persistent antigen exposure induces inevitably pulmonary fibrosis in chronic HP. Although neutrophils, Th1 and Th17 cells contribute to lung inflammation in acute phase of HP, there is no clear explanation as to how the immunological reaction occurs just after the inhalation of causative antigens in the chronic phase of HP.

Methods: We examined the inflammatory and immunologic profiles before and after the inhalation provocation test (IPT) in serum and bronchoalveolar lavage fluid (BALF) from patients with chronic bird-related HP (BRHP) and other interstitial lung diseases (ILDs). Read More

Clinics (Sao Paulo) 2019 Feb 4;74:e225. Epub 2019 Feb 4.

Divisao Pulmonar, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Idiopathic pulmonary fibrosis is a chronic disease of unknown etiology that usually has a progressive course and is commonly associated with a poor prognosis. The main symptoms of idiopathic pulmonary fibrosis, including progressive dyspnea and dry cough, are often nonspecific. Chest high-resolution computed tomography is the primary modality used in the initial assessment of patients with suspected idiopathic pulmonary fibrosis and may have considerable influence on subsequent management decisions. Read More

Psychosom Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Psychiatry, Brigham and Women's Hospital, Boston MA.

Major Depression, as well as other depressive disorders, are commonly comorbid with other medical illnesses, particularly chronic and systemic medical illnesses. The cooccurrence of the disorders is so common that it challenges our notions of the meaning of comorbidity and our desire to neatly separate psychiatric and medical illnesses. The overlap between symptoms of physical illness and the neurovegetative symptoms of major depression and the initial normative emotional response to physical illness add to the challenge of accurate diagnosis and timely treatment of depression in the medically ill. Read More

Semin Roentgenol 2019 Jan 27;54(1):37-43. Epub 2018 Dec 27.

Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY. Electronic address:

Chest 2019 Jan 17. Epub 2019 Jan 17.

Division of Pulmonary & Critical Care & Sleep Medicine (Dr Noth), Department of Medicine, University of Virginia, VA.

Fibrotic interstitial lung diseases (ILDs) have a high mortality rate with an unpredictable disease course and clinical features that frequently overlap. Recent data indicate important roles for genomics in the mechanisms underlying susceptibility and progression of pulmonary fibrosis. The impact of these genomic markers on pharmacotherapy and their contribution to outcomes is increasingly recognized. Read More

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine. Electronic address:

Background: Miliary nodules have been typically described as a radiological manifestation of disseminated tuberculosis. However, miliary nodules are known to occur in a wide variety of conditions. The primary objective of the study was to identify clinical characteristics and etiologies of miliary nodules within our institution. Read More

Ann Am Thorac Soc 2019 Jan 17. Epub 2019 Jan 17.

University of Chicago, Radiology, Chicago, Illinois, United States.

Rationale: Honeycombing on chest computed tomography (CT) has been described in diverse forms of interstitial lung disease (ILD), however, its prevalence and association with mortality across the spectrum of ILD remains unclear.

Objective: To determine the prevalence and prognostic value of CT honeycombing and characterize associated mortality patterns across diverse ILD subtypes in a multicenter cohort.

Methods: Observational cohort study of adult participants with multidisciplinary or adjudicated ILD diagnosis and documentation of chest CT imaging at index diagnosis across five US hospitals (one tertiary and four non-tertiary medical centers). Read More

QJM 2019 Jan 15. Epub 2019 Jan 15.

Southmead General Hospital, North Bristol Lung.

Curr Opin Allergy Clin Immunol 2019 Jan 14. Epub 2019 Jan 14.

Vall d'Hebron Institut de Recerca (VHIR).

Purpose Of Review: To discuss the diagnostic methods currently used in the study of patients with hypersensitivity pneumonitis, with special emphasis on the most recent contributions published in the medical literature regarding the diagnosis of occupational hypersensitivity pneumonitis (OHP). This review presents an update of the use of these diagnostic tests, a controversial issue among experts.

Recent Findings: In spite of the multiple attempts at systematization and the publication of expert consensus statements, standardizing and diagnostic methods and criteria remain particularly difficult. Read More

Ann Allergy Asthma Immunol 2019 Jan 12. Epub 2019 Jan 12.

Servicio de Neumología Hospital Universitario Vall d'Hebron, Barcelona, Spain; Centro de Investigación en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Department of Cell Biology, Physiology, and Immunology, Universitat Autònoma de Barcelona, Barcelona, Spain.

Lung India 2019 Jan-Feb;36(1):48-59

Department of Pulmonary Medicine, Christian Medical College, Vellore, India.

Background: Bronchoscopic lung cryobiopsy (BLC) is a novel technique for obtaining lung tissue for the diagnosis of diffuse parenchymal lung diseases. The procedure is performed using several different variations of technique, resulting in an inconsistent diagnostic yield and a variable risk of complications. There is an unmet need for standardization of the technical aspects of BLC. Read More

Ann Agric Environ Med 2018 Dec 10;25(4):651-655. Epub 2018 Jan 10.

Department of Gastroenterology, Metabolic and Internal Diseases and Dietetics, Poznań, Poland.

Indoor swimming pools can be used all year round and serve for one of the most popular sport pursued for recreation. The positive effect of swimming arises in particular from the involvement of all the muscles of the body, decreasing the burden on the joints, as well as functional improvement of both the lungs and heart. Chlorine is typically used to disinfect swimming pool water and as a result the changes that take place lead to the formation of by-products, such as monochloramines (NH₂Cl), dichloramines (NH₂Cl₂) i trichloramines (NH₂Cl₃), trihalogenometans (THM) or haloacetic acid (HAA). Read More

Eur Respir Rev 2018 Dec 21;27(150). Epub 2018 Dec 21.

Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK.

Although these conditions are rare, a proportion of patients with interstitial lung diseases (ILDs) may develop a progressive-fibrosing phenotype. Progressive fibrosis is associated with worsening respiratory symptoms, lung function decline, limited response to immunomodulatory therapies, decreased quality of life and, potentially, early death. Idiopathic pulmonary fibrosis may be regarded as a model for other progressive-fibrosing ILDs. Read More

Eur Respir Rev 2018 Dec 21;27(150). Epub 2018 Dec 21.

Pulmonary Medicine, Cetrángolo Hospital, Buenos Aires, Argentina.

A proportion of patients with interstitial lung diseases (ILDs) are at risk of developing a progressive-fibrosing phenotype, which is associated with a deterioration in lung function and early mortality. In addition to idiopathic pulmonary fibrosis (IPF), fibrosing ILDs that may present a progressive phenotype include idiopathic nonspecific interstitial pneumonia, connective tissue disease-associated ILDs, hypersensitivity pneumonitis, unclassifiable idiopathic interstitial pneumonia, ILDs related to other occupational exposures and sarcoidosis. Corticosteroids and/or immunosuppressive therapies are sometimes prescribed to patients with these diseases. Read More

J Clin Med 2018 Dec 21;8(1). Epub 2018 Dec 21.

Department of Respiratory Diseases, Unit for interstitial lung diseases, University Hospitals Leuven, Leuven B-3000, Belgium.

Background: Although the third most frequent interstitial lung disease, hypersensitivity pneumonitis (HP) remains an enigmatic disease without clear diagnostic and therapeutic guidelines. We assessed the effect of the commonly used therapeutic interventions (i.e. Read More

Rev Mal Respir 2019 Jan 17;36(1):57-62. Epub 2018 Dec 17.

Université François Rabelais, Inserm U1100, faculté de médecine de Tours, 37000 Tours, France.

Introduction: Mycobacterium avium complex can be responsible for a number of different radio-clinical presentations, ranging from invasive infections to hypersensitivity pneumonitis due to repeated inhalation of antigens. The diagnosis of hypersensitivity pneumonitis is clinical, radiological, biological and microbiological.

Case Report: A 61-year-old male developed a hypersensitivity pneumonitis reaction to non-tuberculous mycobacteria, following the repeated use of his own spa, which later evolved into chronic respiratory failure. Read More

Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.

Chronic hypersensitivity pneumonitis is an interstitial pneumonia caused by an immunological reaction to the chronic inhalation of an antigen. Little is known, however, about the pathological change of the pulmonary lesions. A 33-year-old man was diagnosed with chronic bird-related hypersensitivity pneumonitis based on the findings of a surgical lung biopsy and an inhalation provocation test. Read More

Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.

Pulmonary veno-occlusive disease (PVOD) is a rare disease in the subgroup of conditions known as pulmonary arterial hypertension. Although a histological examination is needed for a definitive diagnosis, a non-invasive diagnosis is required for patients with pulmonary hypertension because a lung biopsy is deemed risky. We herein report a 32-year-old woman diagnosed with PVOD via a surgical lung biopsy and autopsy whose disease showed radiological findings mimicking those of hypersensitivity pneumonitis (pneumonia) at the time of the transbronchial lung biopsy, without obvious pulmonary hypertension on admission. Read More

Lung 2019 Feb 14;197(1):113-114. Epub 2018 Dec 14.

Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75219, USA.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Office of Surveillance and Epidemiology, Division of Pharmacovigilance, FDA Center for Drug Evaluation and Research, Silver Spring, Maryland.

Importance: The US Food and Drug Administration (FDA) conducts ongoing public health safety surveillance for drug and therapeutic biologic products. Identifying cases of acute and subacute noninfectious pneumonia supports the public health mission of the FDA.

Objective: To identify and analyze postmarketing cases of noninfectious pneumonia associated with ustekinumab use. Read More

Adv Exp Med Biol 2018 ;995:131-149

Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Checkpoint inhibitors are part of the family of immunotherapies and are increasingly being used in a wide variety of cancers. Immune-related adverse events pose a major challenge in the treatment of cancer patients. Pneumonitis is a rare immune-related adverse event that presents in distinct patterns. Read More

J Investig Allergol Clin Immunol 2018 Dec;28(6):441-442

Department of Respiratory Diseases, University Hospital of Besançon, Besançon, France.

Allergy 2018 Dec 4. Epub 2018 Dec 4.

Servicio de Neumología, Departamento de Medicina, Hospital Universitario Vall d'Hebron, Universidad Autónoma de Barcelona, Barcelona, Cataluña, España.

Introduction: The objective of this study was to analyze mortality, possible predictors of long-term survival, and health-related quality of life of a large chronic hypersensitivity pneumonitis (CHP) patient sample.

Methods: Longitudinal study in patients diagnosed with CHP during 2004-2013, followed for at least 1 year. Patients remaining alive and consenting to participate had a follow-up visit during 2015, including a complete pulmonary function study and the EuroQol-5D and Beck Depression and Anxiety Inventories. Read More

Tuberk Toraks 2018 Sep;66(3):212-216

Department of Pathology, Faculty of Medicine, Karadeniz Teknik University, Trabzon, Turkey.

Introduction: Granulomatous lung disease (GLD) is caused by a wide range of conditions and it is challenge for pulmonologist. A detailed history of exposures is fundamental in GDL and has been found pivotal to reach a precise diagnosis.

Materials And Methods: Between September 2014 and December 2016, the distribution of patients diagnosed with granulomatous lymphadenitis in the mediastinal/hilar lymph nodes by endobronchial ultrasound (EBUS) or mediastinoscopy was analyzed. Read More

J Clin Med 2018 Nov 24;7(12). Epub 2018 Nov 24.

Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Interstitial lung disease (ILD) and pulmonary fibrosis comprise a wide array of inflammatory and fibrotic lung diseases which are often confusing to general medicine and pulmonary physicians alike. In addition to the myriad of clinical and radiologic nomenclature used in ILD, histopathologic descriptors may be particularly confusing, and are often extrapolated to radiologic imaging patterns which may further add to the confusion. We propose that rather than focusing on precise histologic findings, focus should be on identifying an accurate etiology of ILD through a comprehensive and detailed medical history. Read More

Rev Mal Respir 2018 Nov 22. Epub 2018 Nov 22.

Service des maladies infectieuses et de réanimation médicale, CHU de Rennes, 35043 Rennes, France; Inserm-CIC-1414, faculté de médecine, IFR 140, université de Rennes I, 35033 Rennes, France.

Introduction: The aim of our study was to compare the features at diagnosis in patients with ornithosis to patients with avian acute hypersensitivity pneumonitis (HP). Clinical, biological and radiological differences could potentially help clinicians to distinguish these diseases.

Methods: We conducted a retrospective study on patients admitted from 2000 to 2016 in three hospitals. Read More

Eur Respir J 2019 Feb 31;53(2). Epub 2019 Jan 31.

Center for Interstitial Lung Diseases (CILD), Dept of Medicine, University of Washington, Seattle, WA, USA.

J Allergy Clin Immunol 2018 Nov 15. Epub 2018 Nov 15.

Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill. Electronic address:

Hypersensitivity pneumonitis (HP) is a T1 lymphocyte-biased fibrosing alveolitis caused by antigens ranging from avian excreta, fungi, thermophilic bacteria, and protozoa to reactive chemicals found in the workplace. Mimicking a viral syndrome, acute exposures to inciting antigens cause abrupt onset of nonproductive cough, dyspnea, and chills with arthralgias or malaise usually from 4 to 8 hours later so that the temporal relationship between antigen exposure and symptoms might be unsuspected. The histology of HP reveals prominent lymphocyte infiltrates that thicken the alveolar septa with poorly formed granulomas or giant cells. Read More

Children (Basel) 2018 Nov 12;5(11). Epub 2018 Nov 12.

Department of Pediatric Medicine, Hamad Medical Corporation, Doha 3050, Qatar.

Bird Fancier's Lung (BFL) is a rare, nonatopic immunologic response to repeated or intense inhalation of avian (bird) proteins/antigens found in the feathers or droppings of many species of birds, which leads to an immune-mediated inflammatory reaction in the respiratory system. Although this is the most common type of hypersensitivity pneumonitis (HP) reported in adults, it is one of the classifications of a rare subtype of interstitial lung disease that occurs in the pediatric age group of which few case reports are available in the literature. The pathophysiology of HP is complex; numerous organic and inorganic antigens can cause immune dysregulation, leading to an immune-related antigen⁻antibody response (immunoglobulin G-IgG- against the offending antigen). Read More

Respir Res 2018 Nov 8;19(1):215. Epub 2018 Nov 8.

Pneumology Research Group, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.

Background: The soluble receptor for advanced glycation end-products (sRAGE) has been suggested that it acts as a decoy for capturing advanced glycation end-products (AGEs) and inhibits the activation of the oxidative stress and apoptotic pathways. Lung AGEs/sRAGE is increased in idiopathic pulmonary fibrosis (IPF). The objective of the study was to evaluate the AGEs and sRAGE levels in serum as a potential biomarker in IPF. Read More

Respir Med Case Rep 2018 26;25:330-332. Epub 2018 Oct 26.

Department of Pulmonary Medicine, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba 296-8602, Japan.

We report a case of chronic hypersensitivity pneumonitis treated with pirfenidone in a 76-year-old woman who complained of acute-onset abdominal pain and rashes. The patient was diagnosed with disseminated varicella-zoster virus (VZV) infection, and pirfenidone was discontinued. Her condition improved in one month. Read More

Rev Mal Respir 2018 Nov 2. Epub 2018 Nov 2.

Service de pneumologie, CHU Jean-Minjoz, 2, boulevard Fleming, 25030 Besançon cedex, France.

Introduction: Hot tub lung is a hypersensitivity pneumonitis (HP) due to exposure to inhaled non-tuberculous mycobacteria, the most frequent being Mycobacterium avium complex (MAC).

Case Report: A French couple developed typicalHP in the context of a repeated use of hot tubs. The husband had a severe hypoxemic form whereas his wife had a micronodular form with patchy ground glass on the thoracic scan, with less severe functional impairment. Read More

Pediatr Pulmonol 2018 Dec 23;53(12):1619-1626. Epub 2018 Oct 23.

Department of Radiology, School of Medicine Anschutz Medical Campus, University of Colorado, Aurora, Colorado.

Marijuana use has risen dramatically over the past decade. Over this same time period, pediatric hospitals have seen an increase in presentation of adolescents with acute respiratory symptoms after recent marijuana inhalation. We report a case series of three adolescent males with significant findings of bilateral pulmonary nodules and ground glass opacities on chest imaging associated with recent marijuana inhalation. Read More

ERJ Open Res 2018 Oct 3;4(4). Epub 2018 Oct 3.

Dept of Occupational Medicine, Haukeland University Hospital, Bergen, Norway.

http://ow.ly/GbEf30lFnyk. Read More

Intern Emerg Med 2019 Jan 29;14(1):39-43. Epub 2018 Sep 29.

Section of Respiratory Medicine, Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy.

Idiopathic pulmonary fibrosis is a peripheral subpleural interstitial lung disorder limited to the lung not involving the airways. It has a poor prognosis (survival less than 5 years) and commonly an interstitial pneumonia radiological pattern. Patients complain of a chronic dry cough in 80% of cases. Read More

Chest 2018 Sep 19. Epub 2018 Sep 19.

Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI.

Background: Hypersensitivity pneumonitis (HP) is an interstitial lung disease with a better prognosis, on average, than idiopathic pulmonary fibrosis (IPF). We compare survival time and pulmonary function trajectory in patients with HP and IPF by radiologic phenotype.

Methods: HP (n = 117) was diagnosed if surgical/transbronchial lung biopsy, BAL, and exposure history results suggested this diagnosis. Read More

BMC Infect Dis 2018 Sep 18;18(1):470. Epub 2018 Sep 18.

Centro de Ciências da Saúde, Laboratório de Micologia Médica e Molecular, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte, Rua Gal. Gustavo Cordeiro de Faria S/N, Petrópolis, Natal, Rio Grande do Norte, Brazil.

Background: Trichosporon species may colonize the skin, respiratory tract and gastrointestinal tract of human beings. The yeast is recognized as etiological agent of white piedra, a superficial mycosis. Nevertheless, immunocompromised hosts may develop invasive Trichosporonosis. Read More

PLoS One 2018 12;13(9):e0203779. Epub 2018 Sep 12.

Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, México.

Background And Objective: Idiopathic Pulmonary Fibrosis (IPF) is a progressive disease of unknown etiology. The diagnosis is based on the identification of a pattern of usual interstitial pneumonia either by high resolution computed tomography and/or histology. However, a similar pattern can be observed in other fibrotic lung disorders, and precise diagnosis remains challenging. Read More

Int J Med Microbiol 2018 Dec 3;308(8):1018-1026. Epub 2018 Sep 3.

University Hospital of Wuerzburg, Department of Internal Medicine II, Division of Infectious Diseases, Josef-Schneider-Str. 2, 97080 Wuerzburg, Germany; The University of Texas MD Anderson Cancer Center, Department of Infectious Diseases, 1515 Holcombe Boulevard, Houston, Texas, 77030, United States. Electronic address:

Mold specific T-cells have been described as a supportive biomarker to monitor invasive mycoses and mold exposure. This study comparatively evaluated frequencies and cytokine profiles of Aspergillus fumigatus and Mucorales reactive T-cells depending on environmental mold exposure. Peripheral blood mononuclear cells (PBMCs) obtained from 35 healthy donors were stimulated with mycelial lysates of A. Read More

Med Sci (Basel) 2018 Sep 4;6(3). Epub 2018 Sep 4.

Department of Respiratory Medicine, El Bierzo Hospital, 24404 Ponferrada, Spain.

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fibrotic interstitial lung disease of unknown origin with a characteristic imaging and histologic pattern called usual interstitial pneumonia (UIP). The diagnosis of IPF is a complex procedure that requires the support of various specialists, who must integrate clinical, radiological, and histological data. The multidisciplinary team (MDT) has become the new gold standard to diagnose and manage the disease, increasing the accuracy and agreement of the diagnosis between different centers. Read More

Lung India 2018 Sep-Oct;35(5):428-430

Department of Parenchymal Lung Disease, Institute of Pulmocare and Research, Kolkata, West Bengal, India.

The revelation of interstitial lung disease India registry leads one to consider a revisit into the classification of diffuse parenchymal lung disease that would be clinically relevant for the Indian subcontinent. The author ponders that a simple clinical classification based on steroid sensitivity may be worthwhile. Read More

ERJ Open Res 2018 Jul 22;4(3). Epub 2018 Aug 22.

Divisao de Pneumologia, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sâo Paulo, Sâo Paulo, Brazil.

Small airway and interstitial pulmonary involvements are prominent in chronic hypersensitivity pneumonitis (cHP). However, their roles on exercise limitation and the relationship with functional lung tests have not been studied in detail. Our aim was to evaluate exercise performance and its determinants in cHP. Read More

Arerugi 2018;67(7):954-958

Department of Respiratory Medicine, Tokyo Medical and Dental University.

A man in his 60's with interstitial pneumonitis who was previously admitted to another hospital was transferred to our hospital for further investigations 6 years prior to an acute exacerbation. Given his history of avian contact, the presence of antibodies specific to avian antigen, and a positive result of the inhalation provocation test using pigeon dropping extracts, he was diagnosed with bird-related hypersensitivity pneumonitis (BRHP). As such, we instructed the patient to avoid exposure to avian antigen, and regularly measured the level of avian antigen in dust samples collected from his household environment. Read More

Arerugi 2018;67(7):948-953

Itabashi Chuo Medical Center.

A 53-year-old-woman presented our hospital with 1 month history of exertional dyspnea and mild fever. When examined, temperature was 37.2℃ and her respiratory rate of 22/min with an O2 saturation of 95% (02 4L/min), the rest of her vital signs were normal. Read More