5,241 results match your criteria Hypersensitivity Pneumonitis


Increasing Hypersensitivity Pneumonitis-Related Mortality in the United States from 1988 to 2016.

Am J Respir Crit Care Med 2019 Feb 15. Epub 2019 Feb 15.

National Jewish Health, Pulmonary, Critical Care and Sleep Medicine, Denver, Colorado, United States.

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http://dx.doi.org/10.1164/rccm.201807-1258LEDOI Listing
February 2019

NK and NKT cells in the diagnosis of diffuse lung diseases presenting with a lymphocytic alveolitis.

BMC Pulm Med 2019 Feb 13;19(1):39. Epub 2019 Feb 13.

Department of Pulmonology, Hospital de São João and Faculty of Medicine, University of Porto, Porto, Portugal.

Background: Diffuse lung diseases (DLD) are characterized by different immunophenotypes in the bronchoalveolar lavage fluid (BALF). We aimed to evaluate the diagnostic value of BALF NK and NKT cell counts of patients with DLD and lymphocytic alveolitis.

Methods: We assessed 202 patients with DLD, who underwent BALF immunophenotyping. Read More

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http://dx.doi.org/10.1186/s12890-019-0802-1DOI Listing
February 2019

'When you hear hooves, think zebras, not horses'; two challenging cases of interstitial lung disease (ILD).

BMJ Case Rep 2019 Feb 11;12(2). Epub 2019 Feb 11.

Department of Respiratory Medicine, St Vincent's University Hospital, Dublin, Ireland.

Our case series describes two siblings with complex fibrosing lung diseases. The first patient was initially given a diagnosis of sarcoidosis based on imaging and exclusion of alternative diagnoses. A number of years after diagnosis, he had rapid deterioration of his disease and following surgical lung biopsy, his lung fibrosis was re-classified as chronic hypersensitivity pneumonitis (cHP) with a usual interstitial pneumonia pattern. Read More

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http://dx.doi.org/10.1136/bcr-2018-224507DOI Listing
February 2019

Hypersensitivity reaction with multi-organ failure following re-exposure to rifampicin: case report and review of the literature including WHO spontaneous safety reports.

BMC Pharmacol Toxicol 2019 Feb 12;20(1). Epub 2019 Feb 12.

Department of Clinical Pharmacology & Toxicology, University Hospital Basel, Basel, Switzerland.

Background: True hypersensitivity reactions to rifampicin are relatively rare, nonetheless severe manifestations mostly involving a single organ have been documented. We report a case of acute multi-organ failure occurring after a medication error with re-exposure to rifampicin.

Case Presentation: A 68-year old patient developed acute hypersensitivity pneumonitis, acute renal failure, acute liver failure and haemolytic anemia within hours after a second re-exposure to Rifampicin for the treatment of a hip prosthesis infection with Staphylococcus epidermidis. Read More

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http://dx.doi.org/10.1186/s40360-019-0289-7DOI Listing
February 2019

Diagnostics and acknowledgement of occupational diseases - topics and challenges in the Czech Republic.

Cas Lek Cesk 2019 ;157(8):396-399

The causes of occupational diseases are changing, thats why a regular update of Czech List of Occupational Diseases is needed. New compensable occupational diseases, such as cancer of the larynx and ovarian cancer due to asbestos, and chronic obstructive pulmonary diseases due to black coal dust were included in the last two updates of the Czech List. The need of an early examination at the Centers of Occupational Diseases is stressed in this article, especially before a surgery or other treatment of epicondylitis and carpal tunnel syndrome. Read More

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January 2019

Interstitial Lung Diseases in Developing Countries.

Ann Glob Health 2019 Jan 22;85(1). Epub 2019 Jan 22.

Interstitial Lung Disease Unit, Pulmonology Service, Bellvitge University Hospital. Instituto de Investigación Biomédica de Bellvitge (IDIBELL).

More than 100 different conditions are grouped under the term interstitial lung disease (ILD). A diagnosis of an ILD primarily relies on a combination of clinical, radiological, and pathological criteria, which should be evaluated by a multidisciplinary team of specialists. Multiple factors, such as environmental and occupational exposures, infections, drugs, radiation, and genetic predisposition have been implicated in the pathogenesis of these conditions. Read More

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http://dx.doi.org/10.5334/aogh.2414DOI Listing
January 2019
1 Read

Acute inflammatory and immunologic responses against antigen in chronic bird-related hypersensitivity pneumonitis.

Allergol Int 2019 Feb 5. Epub 2019 Feb 5.

Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:

Background: Hypersensitivity pneumonitis (HP) is an immune-mediated lung disease induced by the inhalation of a wide variety of antigens and a persistent antigen exposure induces inevitably pulmonary fibrosis in chronic HP. Although neutrophils, Th1 and Th17 cells contribute to lung inflammation in acute phase of HP, there is no clear explanation as to how the immunological reaction occurs just after the inhalation of causative antigens in the chronic phase of HP.

Methods: We examined the inflammatory and immunologic profiles before and after the inhalation provocation test (IPT) in serum and bronchoalveolar lavage fluid (BALF) from patients with chronic bird-related HP (BRHP) and other interstitial lung diseases (ILDs). Read More

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http://dx.doi.org/10.1016/j.alit.2018.12.010DOI Listing
February 2019
1 Read

Imaging in idiopathic pulmonary fibrosis: diagnosis and mimics.

Clinics (Sao Paulo) 2019 Feb 4;74:e225. Epub 2019 Feb 4.

Divisao Pulmonar, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Idiopathic pulmonary fibrosis is a chronic disease of unknown etiology that usually has a progressive course and is commonly associated with a poor prognosis. The main symptoms of idiopathic pulmonary fibrosis, including progressive dyspnea and dry cough, are often nonspecific. Chest high-resolution computed tomography is the primary modality used in the initial assessment of patients with suspected idiopathic pulmonary fibrosis and may have considerable influence on subsequent management decisions. Read More

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http://dx.doi.org/10.6061/clinics/2019/e225DOI Listing
February 2019
1 Read

Major depressive disorder in medical illness: A review of assessment, prevalence, and treatment options.

Psychosom Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Psychiatry, Brigham and Women's Hospital, Boston MA.

Major Depression, as well as other depressive disorders, are commonly comorbid with other medical illnesses, particularly chronic and systemic medical illnesses. The cooccurrence of the disorders is so common that it challenges our notions of the meaning of comorbidity and our desire to neatly separate psychiatric and medical illnesses. The overlap between symptoms of physical illness and the neurovegetative symptoms of major depression and the initial normative emotional response to physical illness add to the challenge of accurate diagnosis and timely treatment of depression in the medically ill. Read More

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http://dx.doi.org/10.1097/PSY.0000000000000678DOI Listing
February 2019
2 Reads

Hypersensitivity Pneumonitis.

Semin Roentgenol 2019 Jan 27;54(1):37-43. Epub 2018 Dec 27.

Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY. Electronic address:

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http://dx.doi.org/10.1053/j.ro.2018.12.004DOI Listing
January 2019
1 Read

Integrating Genomics Into Management of Fibrotic Interstitial Lung Disease.

Chest 2019 Jan 17. Epub 2019 Jan 17.

Division of Pulmonary & Critical Care & Sleep Medicine (Dr Noth), Department of Medicine, University of Virginia, VA.

Fibrotic interstitial lung diseases (ILDs) have a high mortality rate with an unpredictable disease course and clinical features that frequently overlap. Recent data indicate important roles for genomics in the mechanisms underlying susceptibility and progression of pulmonary fibrosis. The impact of these genomic markers on pharmacotherapy and their contribution to outcomes is increasingly recognized. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00123692193000
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http://dx.doi.org/10.1016/j.chest.2018.12.011DOI Listing
January 2019
6 Reads

Clinical Characteristics and Etiologies of Miliary Nodules in the US: A Single-Center Study.

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine. Electronic address:

Background: Miliary nodules have been typically described as a radiological manifestation of disseminated tuberculosis. However, miliary nodules are known to occur in a wide variety of conditions. The primary objective of the study was to identify clinical characteristics and etiologies of miliary nodules within our institution. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.12.030DOI Listing
January 2019
2 Reads

CT Honeycombing Identifies a Progressive Fibrotic Phenotype with Increased Mortality Across Diverse Interstitial Lung Diseases.

Ann Am Thorac Soc 2019 Jan 17. Epub 2019 Jan 17.

University of Chicago, Radiology, Chicago, Illinois, United States.

Rationale: Honeycombing on chest computed tomography (CT) has been described in diverse forms of interstitial lung disease (ILD), however, its prevalence and association with mortality across the spectrum of ILD remains unclear.

Objective: To determine the prevalence and prognostic value of CT honeycombing and characterize associated mortality patterns across diverse ILD subtypes in a multicenter cohort.

Methods: Observational cohort study of adult participants with multidisciplinary or adjudicated ILD diagnosis and documentation of chest CT imaging at index diagnosis across five US hospitals (one tertiary and four non-tertiary medical centers). Read More

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https://www.atsjournals.org/doi/10.1513/AnnalsATS.201807-443
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http://dx.doi.org/10.1513/AnnalsATS.201807-443OCDOI Listing
January 2019
7 Reads

Diagnosis of occupational hypersensitivity pneumonitis.

Curr Opin Allergy Clin Immunol 2019 Jan 14. Epub 2019 Jan 14.

Vall d'Hebron Institut de Recerca (VHIR).

Purpose Of Review: To discuss the diagnostic methods currently used in the study of patients with hypersensitivity pneumonitis, with special emphasis on the most recent contributions published in the medical literature regarding the diagnosis of occupational hypersensitivity pneumonitis (OHP). This review presents an update of the use of these diagnostic tests, a controversial issue among experts.

Recent Findings: In spite of the multiple attempts at systematization and the publication of expert consensus statements, standardizing and diagnostic methods and criteria remain particularly difficult. Read More

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http://Insights.ovid.com/crossref?an=00130832-900000000-9918
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http://dx.doi.org/10.1097/ACI.0000000000000511DOI Listing
January 2019
6 Reads

Concomitant hypersensitivity pneumonitis and occupational asthma caused by 2 different etiologic agents.

Ann Allergy Asthma Immunol 2019 Jan 12. Epub 2019 Jan 12.

Servicio de Neumología Hospital Universitario Vall d'Hebron, Barcelona, Spain; Centro de Investigación en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Department of Cell Biology, Physiology, and Immunology, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.anai.2019.01.007DOI Listing
January 2019
1 Read

Bronchoscopic lung cryobiopsy: An Indian association for bronchology position statement.

Lung India 2019 Jan-Feb;36(1):48-59

Department of Pulmonary Medicine, Christian Medical College, Vellore, India.

Background: Bronchoscopic lung cryobiopsy (BLC) is a novel technique for obtaining lung tissue for the diagnosis of diffuse parenchymal lung diseases. The procedure is performed using several different variations of technique, resulting in an inconsistent diagnostic yield and a variable risk of complications. There is an unmet need for standardization of the technical aspects of BLC. Read More

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http://www.lungindia.com/text.asp?2019/36/1/48/249179
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http://dx.doi.org/10.4103/lungindia.lungindia_75_18DOI Listing
January 2019
17 Reads

Influence of chlorinated water on the development of allergic diseases - An overview.

Ann Agric Environ Med 2018 Dec 10;25(4):651-655. Epub 2018 Jan 10.

Department of Gastroenterology, Metabolic and Internal Diseases and Dietetics, Poznań, Poland.

Indoor swimming pools can be used all year round and serve for one of the most popular sport pursued for recreation. The positive effect of swimming arises in particular from the involvement of all the muscles of the body, decreasing the burden on the joints, as well as functional improvement of both the lungs and heart. Chlorine is typically used to disinfect swimming pool water and as a result the changes that take place lead to the formation of by-products, such as monochloramines (NH2Cl), dichloramines (NH2Cl2) i trichloramines (NH2Cl3), trihalogenometans (THM) or haloacetic acid (HAA). Read More

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http://www.journalssystem.com/aaem/Influence-of-chlorinated-
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http://dx.doi.org/10.26444/aaem/79810DOI Listing
December 2018
4 Reads

Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung diseases.

Eur Respir Rev 2018 Dec 21;27(150). Epub 2018 Dec 21.

Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK.

Although these conditions are rare, a proportion of patients with interstitial lung diseases (ILDs) may develop a progressive-fibrosing phenotype. Progressive fibrosis is associated with worsening respiratory symptoms, lung function decline, limited response to immunomodulatory therapies, decreased quality of life and, potentially, early death. Idiopathic pulmonary fibrosis may be regarded as a model for other progressive-fibrosing ILDs. Read More

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http://err.ersjournals.com/lookup/doi/10.1183/16000617.0076-
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http://dx.doi.org/10.1183/16000617.0076-2018DOI Listing
December 2018
15 Reads

Pharmacological management of progressive-fibrosing interstitial lung diseases: a review of the current evidence.

Eur Respir Rev 2018 Dec 21;27(150). Epub 2018 Dec 21.

Pulmonary Medicine, Cetrángolo Hospital, Buenos Aires, Argentina.

A proportion of patients with interstitial lung diseases (ILDs) are at risk of developing a progressive-fibrosing phenotype, which is associated with a deterioration in lung function and early mortality. In addition to idiopathic pulmonary fibrosis (IPF), fibrosing ILDs that may present a progressive phenotype include idiopathic nonspecific interstitial pneumonia, connective tissue disease-associated ILDs, hypersensitivity pneumonitis, unclassifiable idiopathic interstitial pneumonia, ILDs related to other occupational exposures and sarcoidosis. Corticosteroids and/or immunosuppressive therapies are sometimes prescribed to patients with these diseases. Read More

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http://err.ersjournals.com/lookup/doi/10.1183/16000617.0074-
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http://dx.doi.org/10.1183/16000617.0074-2018DOI Listing
December 2018
10 Reads

Effects of Corticosteroid Treatment and Antigen Avoidance in a Large Hypersensitivity Pneumonitis Cohort: A Single-Centre Cohort Study.

J Clin Med 2018 Dec 21;8(1). Epub 2018 Dec 21.

Department of Respiratory Diseases, Unit for interstitial lung diseases, University Hospitals Leuven, Leuven B-3000, Belgium.

Background: Although the third most frequent interstitial lung disease, hypersensitivity pneumonitis (HP) remains an enigmatic disease without clear diagnostic and therapeutic guidelines. We assessed the effect of the commonly used therapeutic interventions (i.e. Read More

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http://dx.doi.org/10.3390/jcm8010014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352061PMC
December 2018
2 Reads

[Hypersensitivity pneumonitis and abscess reaction to nontuberculous mycobacteria acquired form jacuzzi aerosol].

Rev Mal Respir 2019 Jan 17;36(1):57-62. Epub 2018 Dec 17.

Université François Rabelais, Inserm U1100, faculté de médecine de Tours, 37000 Tours, France.

Introduction: Mycobacterium avium complex can be responsible for a number of different radio-clinical presentations, ranging from invasive infections to hypersensitivity pneumonitis due to repeated inhalation of antigens. The diagnosis of hypersensitivity pneumonitis is clinical, radiological, biological and microbiological.

Case Report: A 61-year-old male developed a hypersensitivity pneumonitis reaction to non-tuberculous mycobacteria, following the repeated use of his own spa, which later evolved into chronic respiratory failure. Read More

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http://dx.doi.org/10.1016/j.rmr.2017.10.670DOI Listing
January 2019
1 Read

The Analysis of Surgical Lung Biopsy and Explanted Lung Specimens Sheds Light on the Pathological Progression of Chronic Bird-related Hypersensitivity Pneumonitis.

Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.

Chronic hypersensitivity pneumonitis is an interstitial pneumonia caused by an immunological reaction to the chronic inhalation of an antigen. Little is known, however, about the pathological change of the pulmonary lesions. A 33-year-old man was diagnosed with chronic bird-related hypersensitivity pneumonitis based on the findings of a surgical lung biopsy and an inhalation provocation test. Read More

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http://dx.doi.org/10.2169/internalmedicine.1142-18DOI Listing
December 2018
2 Reads

Pulmonary Veno-occlusive Disease: A Surgical Lung Biopsy-proven and Autopsied Case Radiologically Mimicking Hypersensitivity Pneumonitis at the Time of a Transbronchial Lung Biopsy.

Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.

Pulmonary veno-occlusive disease (PVOD) is a rare disease in the subgroup of conditions known as pulmonary arterial hypertension. Although a histological examination is needed for a definitive diagnosis, a non-invasive diagnosis is required for patients with pulmonary hypertension because a lung biopsy is deemed risky. We herein report a 32-year-old woman diagnosed with PVOD via a surgical lung biopsy and autopsy whose disease showed radiological findings mimicking those of hypersensitivity pneumonitis (pneumonia) at the time of the transbronchial lung biopsy, without obvious pulmonary hypertension on admission. Read More

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http://dx.doi.org/10.2169/internalmedicine.0681-17DOI Listing
December 2018
1 Read

Role of Antigen Type in Survival in Chronic Hypersensitivity Pneumonitis.

Lung 2019 Feb 14;197(1):113-114. Epub 2018 Dec 14.

Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75219, USA.

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http://dx.doi.org/10.1007/s00408-018-0187-6DOI Listing
February 2019
3 Reads

Association of Noninfectious Pneumonia With Ustekinumab Use.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Office of Surveillance and Epidemiology, Division of Pharmacovigilance, FDA Center for Drug Evaluation and Research, Silver Spring, Maryland.

Importance: The US Food and Drug Administration (FDA) conducts ongoing public health safety surveillance for drug and therapeutic biologic products. Identifying cases of acute and subacute noninfectious pneumonia supports the public health mission of the FDA.

Objective: To identify and analyze postmarketing cases of noninfectious pneumonia associated with ustekinumab use. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.4118DOI Listing
December 2018
3 Reads

Immune-Related Adverse Events: Pneumonitis.

Adv Exp Med Biol 2018 ;995:131-149

Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Checkpoint inhibitors are part of the family of immunotherapies and are increasingly being used in a wide variety of cancers. Immune-related adverse events pose a major challenge in the treatment of cancer patients. Pneumonitis is a rare immune-related adverse event that presents in distinct patterns. Read More

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http://dx.doi.org/10.1007/978-3-030-02505-2_6DOI Listing
January 2018

Second Hypersensitivity Pneumonitis in the Same Patient Caused by Chinchillas.

J Investig Allergol Clin Immunol 2018 Dec;28(6):441-442

Department of Respiratory Diseases, University Hospital of Besançon, Besançon, France.

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http://dx.doi.org/10.18176/jiaci.0319DOI Listing
December 2018
1 Read

Long-term outcomes in chronic hypersensitivity pneumonitis.

Allergy 2018 Dec 4. Epub 2018 Dec 4.

Servicio de Neumología, Departamento de Medicina, Hospital Universitario Vall d'Hebron, Universidad Autónoma de Barcelona, Barcelona, Cataluña, España.

Introduction: The objective of this study was to analyze mortality, possible predictors of long-term survival, and health-related quality of life of a large chronic hypersensitivity pneumonitis (CHP) patient sample.

Methods: Longitudinal study in patients diagnosed with CHP during 2004-2013, followed for at least 1 year. Patients remaining alive and consenting to participate had a follow-up visit during 2015, including a complete pulmonary function study and the EuroQol-5D and Beck Depression and Anxiety Inventories. Read More

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http://doi.wiley.com/10.1111/all.13692
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http://dx.doi.org/10.1111/all.13692DOI Listing
December 2018
15 Reads

[Causes of mediastinal/hilar granulomatous lymphadenitis].

Tuberk Toraks 2018 Sep;66(3):212-216

Department of Pathology, Faculty of Medicine, Karadeniz Teknik University, Trabzon, Turkey.

Introduction: Granulomatous lung disease (GLD) is caused by a wide range of conditions and it is challenge for pulmonologist. A detailed history of exposures is fundamental in GDL and has been found pivotal to reach a precise diagnosis.

Materials And Methods: Between September 2014 and December 2016, the distribution of patients diagnosed with granulomatous lymphadenitis in the mediastinal/hilar lymph nodes by endobronchial ultrasound (EBUS) or mediastinoscopy was analyzed. Read More

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http://dx.doi.org/10.5578/tt.67018DOI Listing
September 2018
15 Reads

Interstitial Lung Disease and Pulmonary Fibrosis: A Practical Approach for General Medicine Physicians with Focus on the Medical History.

J Clin Med 2018 Nov 24;7(12). Epub 2018 Nov 24.

Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Interstitial lung disease (ILD) and pulmonary fibrosis comprise a wide array of inflammatory and fibrotic lung diseases which are often confusing to general medicine and pulmonary physicians alike. In addition to the myriad of clinical and radiologic nomenclature used in ILD, histopathologic descriptors may be particularly confusing, and are often extrapolated to radiologic imaging patterns which may further add to the confusion. We propose that rather than focusing on precise histologic findings, focus should be on identifying an accurate etiology of ILD through a comprehensive and detailed medical history. Read More

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http://dx.doi.org/10.3390/jcm7120476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306719PMC
November 2018
5 Reads

[Features distinguishing ornithosis from avian acute hypersensitivity pneumonitis - a retrospective analysis].

Rev Mal Respir 2018 Nov 22. Epub 2018 Nov 22.

Service des maladies infectieuses et de réanimation médicale, CHU de Rennes, 35043 Rennes, France; Inserm-CIC-1414, faculté de médecine, IFR 140, université de Rennes I, 35033 Rennes, France.

Introduction: The aim of our study was to compare the features at diagnosis in patients with ornithosis to patients with avian acute hypersensitivity pneumonitis (HP). Clinical, biological and radiological differences could potentially help clinicians to distinguish these diseases.

Methods: We conducted a retrospective study on patients admitted from 2000 to 2016 in three hospitals. Read More

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http://dx.doi.org/10.1016/j.rmr.2017.11.013DOI Listing
November 2018
1 Read

Hypersensitivity pneumonitis and its correlation with ambient air pollution in urban India.

Eur Respir J 2019 Feb 31;53(2). Epub 2019 Jan 31.

Center for Interstitial Lung Diseases (CILD), Dept of Medicine, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1183/13993003.01563-2018DOI Listing
February 2019
11 Reads
7.636 Impact Factor

Hypersensitivity pneumonitis: A fibrosing alveolitis produced by inhalation of diverse antigens.

J Allergy Clin Immunol 2018 Nov 15. Epub 2018 Nov 15.

Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill. Electronic address:

Hypersensitivity pneumonitis (HP) is a T1 lymphocyte-biased fibrosing alveolitis caused by antigens ranging from avian excreta, fungi, thermophilic bacteria, and protozoa to reactive chemicals found in the workplace. Mimicking a viral syndrome, acute exposures to inciting antigens cause abrupt onset of nonproductive cough, dyspnea, and chills with arthralgias or malaise usually from 4 to 8 hours later so that the temporal relationship between antigen exposure and symptoms might be unsuspected. The histology of HP reveals prominent lymphocyte infiltrates that thicken the alveolar septa with poorly formed granulomas or giant cells. Read More

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http://dx.doi.org/10.1016/j.jaci.2018.09.040DOI Listing
November 2018
2 Reads

A Rare Pediatric Case of Severe Bird Fancier's Lung Presented with Viral Pneumonitis-Like Picture.

Children (Basel) 2018 Nov 12;5(11). Epub 2018 Nov 12.

Department of Pediatric Medicine, Hamad Medical Corporation, Doha 3050, Qatar.

Bird Fancier's Lung (BFL) is a rare, nonatopic immunologic response to repeated or intense inhalation of avian (bird) proteins/antigens found in the feathers or droppings of many species of birds, which leads to an immune-mediated inflammatory reaction in the respiratory system. Although this is the most common type of hypersensitivity pneumonitis (HP) reported in adults, it is one of the classifications of a rare subtype of interstitial lung disease that occurs in the pediatric age group of which few case reports are available in the literature. The pathophysiology of HP is complex; numerous organic and inorganic antigens can cause immune dysregulation, leading to an immune-related antigen⁻antibody response (immunoglobulin G-IgG- against the offending antigen). Read More

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http://dx.doi.org/10.3390/children5110149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262624PMC
November 2018
9 Reads

Serum AGE/RAGEs as potential biomarker in idiopathic pulmonary fibrosis.

Respir Res 2018 Nov 8;19(1):215. Epub 2018 Nov 8.

Pneumology Research Group, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.

Background: The soluble receptor for advanced glycation end-products (sRAGE) has been suggested that it acts as a decoy for capturing advanced glycation end-products (AGEs) and inhibits the activation of the oxidative stress and apoptotic pathways. Lung AGEs/sRAGE is increased in idiopathic pulmonary fibrosis (IPF). The objective of the study was to evaluate the AGEs and sRAGE levels in serum as a potential biomarker in IPF. Read More

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http://dx.doi.org/10.1186/s12931-018-0924-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225674PMC
November 2018
11 Reads

Disseminated varicella-zoster virus infection with abdominal pain possibly caused by pirfenidone: A case report.

Respir Med Case Rep 2018 26;25:330-332. Epub 2018 Oct 26.

Department of Pulmonary Medicine, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba 296-8602, Japan.

We report a case of chronic hypersensitivity pneumonitis treated with pirfenidone in a 76-year-old woman who complained of acute-onset abdominal pain and rashes. The patient was diagnosed with disseminated varicella-zoster virus (VZV) infection, and pirfenidone was discontinued. Her condition improved in one month. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22130071183033
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http://dx.doi.org/10.1016/j.rmcr.2018.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214882PMC
October 2018
7 Reads

[Two cases of hot tub lung disease: Environmental investigations].

Rev Mal Respir 2018 Nov 2. Epub 2018 Nov 2.

Service de pneumologie, CHU Jean-Minjoz, 2, boulevard Fleming, 25030 Besançon cedex, France.

Introduction: Hot tub lung is a hypersensitivity pneumonitis (HP) due to exposure to inhaled non-tuberculous mycobacteria, the most frequent being Mycobacterium avium complex (MAC).

Case Report: A French couple developed typicalHP in the context of a repeated use of hot tubs. The husband had a severe hypoxemic form whereas his wife had a micronodular form with patchy ground glass on the thoracic scan, with less severe functional impairment. Read More

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http://dx.doi.org/10.1016/j.rmr.2018.10.006DOI Listing
November 2018
2 Reads

Marijuana medusa: The many pulmonary faces of marijuana inhalation in adolescent males.

Pediatr Pulmonol 2018 Dec 23;53(12):1619-1626. Epub 2018 Oct 23.

Department of Radiology, School of Medicine Anschutz Medical Campus, University of Colorado, Aurora, Colorado.

Marijuana use has risen dramatically over the past decade. Over this same time period, pediatric hospitals have seen an increase in presentation of adolescents with acute respiratory symptoms after recent marijuana inhalation. We report a case series of three adolescent males with significant findings of bilateral pulmonary nodules and ground glass opacities on chest imaging associated with recent marijuana inhalation. Read More

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http://doi.wiley.com/10.1002/ppul.24171
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http://dx.doi.org/10.1002/ppul.24171DOI Listing
December 2018
14 Reads

The pathogenetic mechanisms of cough in idiopathic pulmonary fibrosis.

Intern Emerg Med 2019 Jan 29;14(1):39-43. Epub 2018 Sep 29.

Section of Respiratory Medicine, Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy.

Idiopathic pulmonary fibrosis is a peripheral subpleural interstitial lung disorder limited to the lung not involving the airways. It has a poor prognosis (survival less than 5 years) and commonly an interstitial pneumonia radiological pattern. Patients complain of a chronic dry cough in 80% of cases. Read More

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http://dx.doi.org/10.1007/s11739-018-1960-5DOI Listing
January 2019
22 Reads

Hypersensitivity Pneumonitis: Radiologic Phenotypes Are Associated With Distinct Survival Time and Pulmonary Function Trajectory.

Chest 2018 Sep 19. Epub 2018 Sep 19.

Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI.

Background: Hypersensitivity pneumonitis (HP) is an interstitial lung disease with a better prognosis, on average, than idiopathic pulmonary fibrosis (IPF). We compare survival time and pulmonary function trajectory in patients with HP and IPF by radiologic phenotype.

Methods: HP (n = 117) was diagnosed if surgical/transbronchial lung biopsy, BAL, and exposure history results suggested this diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00123692183243
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http://dx.doi.org/10.1016/j.chest.2018.08.1076DOI Listing
September 2018
11 Reads

Trichosporon inkin meningitis in Northeast Brazil: first case report and review of the literature.

BMC Infect Dis 2018 Sep 18;18(1):470. Epub 2018 Sep 18.

Centro de Ciências da Saúde, Laboratório de Micologia Médica e Molecular, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte, Rua Gal. Gustavo Cordeiro de Faria S/N, Petrópolis, Natal, Rio Grande do Norte, Brazil.

Background: Trichosporon species may colonize the skin, respiratory tract and gastrointestinal tract of human beings. The yeast is recognized as etiological agent of white piedra, a superficial mycosis. Nevertheless, immunocompromised hosts may develop invasive Trichosporonosis. Read More

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http://dx.doi.org/10.1186/s12879-018-3363-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145100PMC
September 2018
2 Reads

Identification of MMP28 as a biomarker for the differential diagnosis of idiopathic pulmonary fibrosis.

PLoS One 2018 12;13(9):e0203779. Epub 2018 Sep 12.

Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, México.

Background And Objective: Idiopathic Pulmonary Fibrosis (IPF) is a progressive disease of unknown etiology. The diagnosis is based on the identification of a pattern of usual interstitial pneumonia either by high resolution computed tomography and/or histology. However, a similar pattern can be observed in other fibrotic lung disorders, and precise diagnosis remains challenging. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203779PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135486PMC
September 2018
3 Reads

Evaluation of Aspergillus and Mucorales specific T-cells and peripheral blood mononuclear cell cytokine signatures as biomarkers of environmental mold exposure.

Int J Med Microbiol 2018 Dec 3;308(8):1018-1026. Epub 2018 Sep 3.

University Hospital of Wuerzburg, Department of Internal Medicine II, Division of Infectious Diseases, Josef-Schneider-Str. 2, 97080 Wuerzburg, Germany; The University of Texas MD Anderson Cancer Center, Department of Infectious Diseases, 1515 Holcombe Boulevard, Houston, Texas, 77030, United States. Electronic address:

Mold specific T-cells have been described as a supportive biomarker to monitor invasive mycoses and mold exposure. This study comparatively evaluated frequencies and cytokine profiles of Aspergillus fumigatus and Mucorales reactive T-cells depending on environmental mold exposure. Peripheral blood mononuclear cells (PBMCs) obtained from 35 healthy donors were stimulated with mycelial lysates of A. Read More

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http://dx.doi.org/10.1016/j.ijmm.2018.09.002DOI Listing
December 2018
3 Reads
3.614 Impact Factor

Diagnosis of Idiopathic Pulmonary Fibrosis: Differential Diagnosis.

Med Sci (Basel) 2018 Sep 4;6(3). Epub 2018 Sep 4.

Department of Respiratory Medicine, El Bierzo Hospital, 24404 Ponferrada, Spain.

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fibrotic interstitial lung disease of unknown origin with a characteristic imaging and histologic pattern called usual interstitial pneumonia (UIP). The diagnosis of IPF is a complex procedure that requires the support of various specialists, who must integrate clinical, radiological, and histological data. The multidisciplinary team (MDT) has become the new gold standard to diagnose and manage the disease, increasing the accuracy and agreement of the diagnosis between different centers. Read More

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http://dx.doi.org/10.3390/medsci6030073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164303PMC
September 2018
2 Reads

Lessons from the interstitial lung disease-India registry: A proposed practical scheme of classification of diffuse parenchymal lung diseases in the Indian subcontinent.

Lung India 2018 Sep-Oct;35(5):428-430

Department of Parenchymal Lung Disease, Institute of Pulmocare and Research, Kolkata, West Bengal, India.

The revelation of interstitial lung disease India registry leads one to consider a revisit into the classification of diffuse parenchymal lung disease that would be clinically relevant for the Indian subcontinent. The author ponders that a simple clinical classification based on steroid sensitivity may be worthwhile. Read More

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http://dx.doi.org/10.4103/lungindia.lungindia_393_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120319PMC
September 2018
3 Reads

Mechanisms of exercise limitation in patients with chronic hypersensitivity pneumonitis.

ERJ Open Res 2018 Jul 22;4(3). Epub 2018 Aug 22.

Divisao de Pneumologia, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sâo Paulo, Sâo Paulo, Brazil.

Small airway and interstitial pulmonary involvements are prominent in chronic hypersensitivity pneumonitis (cHP). However, their roles on exercise limitation and the relationship with functional lung tests have not been studied in detail. Our aim was to evaluate exercise performance and its determinants in cHP. Read More

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http://dx.doi.org/10.1183/23120541.00043-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104296PMC
July 2018
5 Reads

[A CASE OF ACUTE EXACERBATION OF CHRONIC BIRDRELATED HYPERSENSITIVITY PNEUMONITIS WITH A REMARKABLE ELEVATION OF ENVIRONMENTAL AVIAN ANTIGEN LEVELS].

Arerugi 2018;67(7):954-958

Department of Respiratory Medicine, Tokyo Medical and Dental University.

A man in his 60's with interstitial pneumonitis who was previously admitted to another hospital was transferred to our hospital for further investigations 6 years prior to an acute exacerbation. Given his history of avian contact, the presence of antibodies specific to avian antigen, and a positive result of the inhalation provocation test using pigeon dropping extracts, he was diagnosed with bird-related hypersensitivity pneumonitis (BRHP). As such, we instructed the patient to avoid exposure to avian antigen, and regularly measured the level of avian antigen in dust samples collected from his household environment. Read More

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http://dx.doi.org/10.15036/arerugi.67.954DOI Listing
January 2018
9 Reads

[FAMILIAL OCCURRENCE OF SUMMER-TYPE HYPERSENSITIVITY PNEUMONITIS IN DEFECTIVE HOME].

Arerugi 2018;67(7):948-953

Itabashi Chuo Medical Center.

A 53-year-old-woman presented our hospital with 1 month history of exertional dyspnea and mild fever. When examined, temperature was 37.2℃ and her respiratory rate of 22/min with an O2 saturation of 95% (02 4L/min), the rest of her vital signs were normal. Read More

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http://dx.doi.org/10.15036/arerugi.67.948DOI Listing
January 2018
5 Reads