357,656 results match your criteria Hypersensitivity Pneumonitis
PLoS Genet 2018 Dec 12;14(12):e1007821. Epub 2018 Dec 12.
Cancer Genomics Unit, Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Fanconi Anemia (FA) is a genomic instability syndrome resulting in aplastic anemia, developmental abnormalities, and predisposition to hematological and other solid organ malignancies. Mutations in genes that encode proteins of the FA pathway fail to orchestrate the repair of DNA damage caused by DNA interstrand crosslinks. Zebrafish harbor homologs for nearly all known FA genes. Read More
JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.
Office of Surveillance and Epidemiology, Division of Pharmacovigilance, FDA Center for Drug Evaluation and Research, Silver Spring, Maryland.
Importance: The US Food and Drug Administration (FDA) conducts ongoing public health safety surveillance for drug and therapeutic biologic products. Identifying cases of acute and subacute noninfectious pneumonia supports the public health mission of the FDA.
Objective: To identify and analyze postmarketing cases of noninfectious pneumonia associated with ustekinumab use. Read More
JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.
Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Adv Exp Med Biol 2018 ;995:131-149
Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Checkpoint inhibitors are part of the family of immunotherapies and are increasingly being used in a wide variety of cancers. Immune-related adverse events pose a major challenge in the treatment of cancer patients. Pneumonitis is a rare immune-related adverse event that presents in distinct patterns. Read More
Int Orthop 2018 Dec 11. Epub 2018 Dec 11.
Department of Orthopaedics and Trauma Surgery, University Hospital Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany.
Purpose: The contact allergens nickel, cobalt, and chromium are often discussed as possible triggers of allergic reactions to orthopedic implants. Additionally, acrylates and polymerization additives in bone cement (e.g. Read More
Clin Cosmet Investig Dermatol 2018 23;11:603-611. Epub 2018 Nov 23.
Institute of Medical and Biomedical Education, St George's University of London, London, UK.
The recent rapid growth in dermal filler use, in conjunction with inadequate product and injector control, has heralded a concerning increase in filler complications. The 10-point plan has been developed to minimize complications through careful preconsideration of causative factors, categorized as patient, product, and procedure related. Patient-related factors include history, which involves a preprocedural consultation with careful elucidation of skin conditions, systemic disease, medications, and previous cosmetic procedures. Read More
Onco Targets Ther 2018 21;11:8239-8250. Epub 2018 Nov 21.
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan,
Standard treatment options for patients with advanced gastric cancer (GC) offer limited efficacy and are associated with some toxicity, which necessitates the development of more effective therapies for improving the treatment outcomes for this disease. Immunotherapy involving immune checkpoint inhibitors (ICIs) which inhibit the programmed death 1 (PD-1)/programmed death ligand 1 interaction has emerged as a new treatment option. Nivolumab, a human IgG4 monoclonal antibody inhibitor of PD-1, has demonstrated promising clinical activity and induced durable responses in patients with advanced GC. Read More
Iran J Allergy Asthma Immunol 2018 Aug 12;17(4):393-397. Epub 2018 Aug 12.
Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.
Efficient diagnosis of allergy and proper treatment need identification of the causative allergens eliciting clinical symptoms. The present study was performed to identify the most common aero- and food allergens and determine the pattern of sensitization among people of Ahvaz (southwestern Iran), one of the most polluted cities worldwide. Based on the physical examination and medical records, patients were referred to the Allergy laboratory for "in vitro" IgE determination. Read More
J Cardiol Cases 2013 Dec 29;8(6):176-178. Epub 2013 Oct 29.
Cardiology Department, Heraklion University Hospital, PO Box 1352, 71110 Heraklion, Greece.
Acute coronary syndromes secondary to allergy-induced coronary vasospasm are known as "Kounis syndrome." The main pathophysiological mechanism of coronary spasm in Kounis syndrome is the release of inflammatory mediators during a hypersensitivity reaction triggered by food, insect bites, or drugs. Here, we report a case of an acute coronary syndrome secondary to allergic reaction following levofloxacin administration in a 68-year-old female without a prior history of coronary artery disease. Read More
Contact Dermatitis 2018 Dec 10. Epub 2018 Dec 10.
Department of Cutaneous Allergy, St John's Institute of Dermatology, Guy's & St Thomas' NHS Foundation Trust, London, UK.
There is a lack of published data on the role of patch testing in patients with so-called multiple chemical sensitivity (MCS), also known as idiopathic environmental intolerances (IEI). This disputed chronic condition is characterised by symptoms that the affected person attributes to low-level exposures to commonly used chemicals. Symptoms are typically vague and non-specific and may include fatigue, headaches, nausea, dizziness, a sensation of skin burning or pain. Read More
J Small Anim Pract 2018 Dec 11. Epub 2018 Dec 11.
Re-Fur-All Referrals, Newbury, Berkshire, UK.
Food intolerance refers to any abnormal physiological response to a food or food additive, believed not to be immunological in nature. Mechanisms include food toxicity, pharmacological reactions, metabolic reactions, dysmotility, dysbiosis, physical effects and non-specific dietary sensitivity. Food intolerance reactions are variable, typically dose-dependent, and can occur at any age. Read More
J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.
Department of Anesthesiology, Quzhou Hospital of Zhejiang University School of Medicine, Quzhou, China.
Peripheral inflammation in male C57BL/6 mice was induced by intraplantar injection of 20 μL complete freund's adjuvant (CFA) in the left hind paw. Mice were randomly divided into three groups: Sham, CFA, and propofol+CFA. Mechanical allodynia was assessed by von Frey analysis, and heat hyperalgesia was detected by exposure of the plantar surface to a beam of radiant heat. Read More
Drug Saf 2018 Dec 10. Epub 2018 Dec 10.
Vifor Pharma Management Ltd., Flughofstrasse 61, 8152, Glattbrugg, Switzerland.
Introduction: Hypersensitivity reactions (HSRs) are among the known adverse events of intravenous (i.v.) iron products. Read More
Inflamm Bowel Dis 2018 Dec 11. Epub 2018 Dec 11.
Department of Gastroenterology, Hepatology & Nutrition, Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio.
Scientific research into the effects and mechanisms of acupuncture for gastrointestinal diseases including inflammatory bowel disease has been rapidly growing in the past several decades. In this review, we discuss the history, theory, and methodology of acupuncture and review potentially beneficial mechanisms of action of acupuncture for managing inflammatory bowel disease. Acupuncture has been shown to decrease disease activity and inflammation via increase of vagal activity in inflammatory bowel disease. Read More
Pain Rep 2018 Sep-Oct;3(5):e676. Epub 2018 Sep 17.
Peripheral Neuropathy Unit, Centre for Clinical Translation, Department of Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom.
Introduction: Granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR) is highly expressed in peripheral macrophages and microglia, and is involved in arthritis and cancer pain in animal models. However, there is limited information on GM-CSFR expression in human central nervous system (CNS), peripheral nerves, or dorsal root ganglia (DRG), particularly in chronic pain conditions.
Objectives: Immunohistochemistry was used to quantify GM-CSFR expression levels in human tissues, and functional sensory effects of GM-CSF were studied in cultured DRG neurons. Read More
Cell Mol Gastroenterol Hepatol 2019 20;7(1):185-196. Epub 2018 Sep 20.
Université Lille, INSERM, CHR Lille, Lille Inflammation Research International Center, U995, Lille, France.
Background & Aims: Irritable bowel syndrome (IBS) is a multifactorial disease arising from a complex interplay between genetic predisposition and environmental influences. To date, environmental triggers are not well known. Aluminum is commonly present in food, notably by its use as food additive. Read More
Hip Pelvis 2018 Dec 6;30(4):276-281. Epub 2018 Dec 6.
Department of Orthopaedics, Korea University Guro Hospital, Seoul, Korea.
Pseudotumors are not uncommon complications after total hip arthroplasty (THA) and may occur due to differences in bearing surfaces of the head and the liner ranging from soft to hard articulation. The most common causes of pseudotumors are foreign-body reaction, hypersensitivity and wear debris. The spectrum of pseudotumor presentation following THA varies greatly-from completely asymptomatic to clear implant failure. Read More
Nurs Open 2019 Jan 19;6(1):136-143. Epub 2018 Aug 19.
Department of Health VID Specialized University Oslo Norway.
Aim: To investigate a possible association between children's current diet and parents' reported avoidance of appropriate foods in the child's diet at the age of 10 months, due to fears of allergic or hypersensitivity reactions.
Design: A cross-sectional study.
Methods: In 10 randomly selected municipalities willing to participate, 686 children represented by their parents visiting the child health centre were enrolled in the study. Read More
Front Pharmacol 2018 23;9:1360. Epub 2018 Nov 23.
Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.
(FLL) has been widely used as a traditional Chinese medicine (TCM) for treating soreness and weakness of waist and knees. It has potential for treating OA owing to its kidney-tonifying activity with bone-strengthening effects, but there is so far no report of its anti-OA effect. This study established a rat OA model by intra-articular (IA) injection of mono-iodoacetate (1. Read More
J Clin Invest 2018 Dec 11. Epub 2018 Dec 11.
Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated subchondral bone remodeling in sensory innervation for OA pain. We show that osteoclasts secrete NETRIN1 to induce sensory nerve axonal growth in subchondral bone. Read More
J Exp Med 2018 Dec 7. Epub 2018 Dec 7.
Leibniz Institute on Aging, Fritz Lipmann Institute (FLI), Jena, Germany
Organism aging is characterized by increased inflammation and decreased stem cell function, yet the relationship between these factors remains incompletely understood. This study shows that aged hematopoietic stem and progenitor cells (HSPCs) exhibit increased ground-stage NF-κB activity, which enhances their responsiveness to undergo differentiation and loss of self-renewal in response to inflammation. The study identifies /cohesin as a critical mediator of NF-κB signaling, which increases chromatin accessibility in the vicinity of NF-κB target genes in response to inflammation. Read More
Eur J Dermatol 2018 Oct;28(5):668-676
Lund University, Skåne University Hospital, Department of Occupational and Environmental Dermatology, S-214 28, Malmö, Sweden.
Concomitant reactions to palladium chloride (PdCl), sodium tetrachloropalladate (NaPdCl), and nickel hexahydrate sulphate (NiSO·6HO) are very common during patch testing and have mainly been explained by cross-sensitisation. Whether there is variation in reactivity to palladium or covariation to nickel and palladium is not known. The aim of this study was to investigate the variation in patch test reactivity to PdCl and NaPdCl over time and compare this to variation in patch test reactivity to NiSO·6HO. Read More
J Investig Allergol Clin Immunol 2018 Dec;28(6):441-442
Department of Respiratory Diseases, University Hospital of Besançon, Besançon, France.
J Investig Allergol Clin Immunol 2018 Dec;28(6):424-426
Allergy Complex Unit, Ospedale Policlinico San Martino, Genoa, Italy.
J Investig Allergol Clin Immunol 2018 Dec;28(6):419-420
Diater S.A. Laboratories, Madrid, Spain.
Addict Behav 2018 Dec 4;90:395-401. Epub 2018 Dec 4.
Department of Psychology, University of South Florida, 4202 East Fowler Ave, PCD 4118G, Tampa, FL 33620, United States.
Biases in outcome processing, mediated by the mesocortical dopaminergic (DA) system, may predict individual differences in the frequency and quantity of alcohol use. We tested the hypothesis that genetic markers associated with increased DA neurotransmission contribute to reduced neural sensitivity to costs and increased alcohol use in an undergraduate sample. We created a DA transmission score using five genetic markers related to DA transmission and assessed neural sensitivity to cost using the feedback-related negativity (FRN), an event-related potential implicated in neural outcome evaluation, on both passive evaluative and active decision-making tasks. Read More
J Mech Behav Biomed Mater 2018 Nov 28;91:38-44. Epub 2018 Nov 28.
Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, 710004 Xi'an, China; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, 710004 Xi'an, China; Department of Prosthodontics, College of Stomatology, Xi'an Jiaotong University, 710004 Xi'an, China. Electronic address:
Objectives: To evaluate the dentinal tubular occlusion of nano-hydroxyapatite (nHAp) containing desensitizing toothpastes and their influence on the resin-dentin bonding performance of two mild self-etch adhesives.
Materials And Methods: Mid-coronal dentin specimens were prepared from obtained intact human third molars. They were immersed in 1% citric acid for 20 s to expose the dentinal tubules to simulate sensitive teeth and then randomly divided into four groups. Read More
J Pain 2018 Dec 7. Epub 2018 Dec 7.
Department of Anesthesiology, Gunma University Graduate School of Medicine, (3-39-22 Showa, Maebashi, Gunma 371-8511, Japan).
A rat model of neuropathic pain at 6 weeks after spinal nerve ligation (SNL6w) exhibits both mechanical hypersensitivity and impaired noxious stimuli-induced analgesia (NSIA). Repeated treatment with antidepressants can produce anti-hypersensitivity and restore NSIA. To examine the involvement of a brain-derived neurotrophic factor-mediated mechanism, a tropomyosin receptor kinase B (TrkB) agonist, 7,8-dihydroxyflavone (DHF), was administered to SNL6w rats (5 mg• kg• day, 5 days). Read More
J Ethnopharmacol 2018 Dec 5. Epub 2018 Dec 5.
Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.
Ethnopharmacological Relevance: Osteoarthritis (OA), characterized by joint pain and cartilage degradation, is the most common form of joint disease worldwide but with no satisfactory therapy available. The ethanol extract of Agkistrodon acutus (EAA) has been widely used as a traditional Chinese medicine (TCM) for the treatment of arthralgia and inflammatory diseases, but there is no report regarding its efficacy on OA to date. Here, we determined the effects of EAA on the pain behavior and cartilage degradation in vivo and clarified its target genes and proteins associated with chondrocyte hypertrophy and apoptosis in vitro. Read More
J Allergy Clin Immunol Pract 2018 Dec 6. Epub 2018 Dec 6.
Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University College of Medicine, Seoul, Korea; Regional Pharmacovigilance Center, Seoul National University Hospital, Seoul, Korea. Electronic address:
Background: Although HLA-B*58:01 is a well-known risk factor for the development of allopurinol-induced severe cutaneous adverse reactions (SCARs), most of the HLA-B*58:01 carriers do not suffer from SCARs despite a long-term use of allopurinol. This suggests that there are other risk factors that determine the fate of HLA-B*58:01 carriers.
Objective: The aim of this study was to investigate the additional genetic factors that increases the risk of allopurinol-induced SCARs in HLA-B*58:01 carriers. Read More
Neuroscience 2018 Dec 4. Epub 2018 Dec 4.
Neuroscience Graduate Program, University of California Riverside, Riverside, California, 92521, USA; Psychology Department and Psychology Graduate Program, University of California Riverside, Riverside, California, 92521, USA. Electronic address:
Fragile X Syndrome (FXS) is a leading genetic cause of autism and intellectual disabilities. Sensory processing deficits are common in humans with FXS and an animal model, the Fmr1 knockout (KO) mouse, manifesting in the auditory system as debilitating hypersensitivity and abnormal electroencephalographic (EEG) and event-related potential (ERP) phenotypes. FXS is a neurodevelopmental disorder, but how EEG/ERP phenotypes change during development is unclear. Read More
Brain Dev 2018 Dec 7. Epub 2018 Dec 7.
Division of Neurology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Thailand. Electronic address:
Background: Super-refractory status epilepticus (SRSE) is a seizure that continues >24 h after anesthesia, or recurs on the reduction of anesthesia. SRSE is extremely difficult-to-control and associated with poor outcome. To date, optimal therapy and outcome data in children is limited. Read More
J Control Release 2018 Dec 5. Epub 2018 Dec 5.
Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education and PLA, Shanghai 201203, China; The Department of Integrative Medicine, Huashan Hospital, Fudan University, and The Institutes of Integrative Medicine of Fudan University, Shanghai 200041, China; Minhang Branch, Zhongshan Hospital and Institute of Fudan-Minghang Academic Health System, Minghang Hospital, Fudan University, Shanghai 201199, China. Electronic address:
Liposomes with peptides motifs have been widely applied for targeted delivery of anticancer drugs. However, few studies have questioned whether peptide modification on liposomes may induce serious toxicity associated with immune stimulation. Here, we report that display of a tumor targeting cyclic RGD peptide (e. Read More
Ital J Pediatr 2018 Dec 7;44(1):147. Epub 2018 Dec 7.
Pediatric Unit, Infant Maternal Department, Azienda Sanitaria Provinciale Crotone, Crotone, Italy.
Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), that aims of ascertaining the causative role of an allergen and evaluating the tolerance to the suspected drug. Read More
Protein Pept Lett 2018 Dec 8. Epub 2018 Dec 8.
Department of Clinical Laboratory , Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi. China.
Background: The dust mite Dermatophagoides farinae is a common worldwide cause of indoor allergies induced by mite proteins, including the mid-tier allergen Der f 7. Objective To identify conformational epitopes in Der f 7 using mimotope mapping and computational modelling.
Methods: Here, we used standard hybridoma technology to generate 3 new monoclonal antibodies against Der f 7 and performed mimotope mapping by probing a random peptide phage display library. Read More
Radiographics 2018 Dec 7:180014. Epub 2018 Dec 7.
From the Department of Radiology, Weill Cornell Medicine, New York-Presbyterian Hospital, 525 E. 68th St, Box 141, New York, NY 10065 (D.B.G.); Department of Radiology, Mayo Clinic Arizona, Scottsdale, Ariz (A.K.) and Phoenix, Ariz (C.O.M.); Department of Radiology, Okayama University Hospital, Okayama, Japan (T.T.); Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY (G.R.S.); Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (S.B.); Departments of Radiology and Medicine, Zucker School of Medicine at Hofstra Northwell, North Shore University Hospital, Manhasset, NY (R.S.); and Department of Radiology, Mayo Clinic, Rochester, Minn (B.F.K.).
Bladder cancer is the sixth most common cancer in the United States, and 70% of cases are non-muscle invasive. Intravesical bacillus Calmette-Guérin (BCG) immunotherapy, administered after transurethral tumor resection, is the most effective adjuvant treatment for intermediate- and high-grade non-muscle-invasive bladder cancer. Despite its weakened state, BCG has the potential to cause multisystem disease in treated patients. Read More
Asian Pac J Allergy Immunol 2018 Dec 9. Epub 2018 Dec 9.
Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke (QC), Canada.
Background: Immediate hypersensitivity reactions to beta-lactams are IgE-mediated and constitute the most common adverse reactions to antibiotics mediated by a specific immunologic mechanism.
Objective: We investigated the association between four functional polymorphisms of IL13 (R130Q variant) and IL4RA (I50V, S478P and Q551R variants) genes and susceptibility to immediate allergic reactions to beta-lactams in the Algerian population.
Methods: We determined these gene variants in 199 patients and 99 healthy controls from Algeria. Read More
Cell Physiol Biochem 2018 6;51(5):2098-2110. Epub 2018 Dec 6.
Background/aims: Bortezomib (BTZ) is largely used as a chemotherapeutic agent for the treatment of multiple myeloma. However, one of the significant limiting complications of BTZ is painful peripheral neuropathy during BTZ therapy. The purpose of this study was to examine the underlying mechanisms leading to neuropathic pain induced by BTZ. Read More
Acta Med Port 2018 Nov 30;31(11):618-623. Epub 2018 Nov 30.
Serviço de Imunoalergologia. Centro Hospitalar de São João. Porto. Portugal.
Introduction: Hymenoptera venom allergy is associated with significant morbidity and deterioration in health-related quality of life, and risk of fatal systemic reactions. Although venom immunotherapy is safe and the only effective treatment in allergic individuals, some patients prefer not to pursue this treatment. Since 2011, when the 50% reimbursement was stopped, patients must fully support the cost of immunotherapy. Read More
J Neurotrauma 2018 Dec 6. Epub 2018 Dec 6.
Emory University School of Medicine, 12239, Department of Physiology , 615 Michael Street , Atlanta, Georgia, United States , 30322 ;
Previously, we showed that noxious stimulation of the tail produces numerous detrimental effects after spinal cord injury (SCI), including an earlier onset and increased magnitude of mechanical hypersensitivity. Expanding on these observations, this study sought to determine whether localized peripheral inflammation similarly impacts the expression of mechanical hypersensitivity after SCI. Adult rats received a moderate contusion injury at thoracic level (Tl0) or sham surgery, and were administered complete Freund's adjuvant (CFA) or vehicle in one hind paw 24 hours later. Read More
J Vet Intern Med 2018 Dec 6. Epub 2018 Dec 6.
Department of Clinical Research, University of Bern, Berne, Switzerland.
Background: Genetic, epidemiologic, and clinical evidence suggests that, in horses, there are manifestations of hypersensitivity that can occur together.
Objectives: To investigate whether concurrent insect bite hypersensitivity (IBH) and severe equine asthma (EA) is associated with higher allergen-specific and total serum immunoglobulin E (IgE) concentrations than only EA or IBH.
Animals: Healthy control horses (C, n = 40), horses with IBH (IBH, n = 24), severe EA (EA, n = 18), and both conditions (IBH/EA, n = 23) were included. Read More
Contact Dermatitis 2018 Dec 5. Epub 2018 Dec 5.
Department of Dermatology, Hospital Universitario Príncipe de Asturias, Madrid, Spain.
Upper eyelid gold weight implants are an established tool in the symptomatic treatment of lagophthalmos, the inability to close your eyes completely. Complications associated to this procedure are infrequent. When noted, non-infectious inflammatory reactions corresponding to type IV hypersensitivity reactions are resolved with the removal of the implant. Read More
Anaesthesia 2018 Dec 5. Epub 2018 Dec 5.
Department of Anaesthesia and Peri-operative Medicine, Monash University, Melbourne, Vic., Australia.
The proportion of patients receiving intravenous gelatin-based colloids has increased in the last decade due to safety concerns about starch-based products. Recent research suggests hypersensitivity reactions to intravenous gelatin-based solutions occur at similar rates per administration as non-depolarising neuromuscular blocking agents such as rocuronium (6.2/100,000 administrations). Read More
Methods Mol Biol 2019 ;1888:153-174
Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
Chemogenomic profiling is a powerful and unbiased approach to elucidate pharmacological targets and the mechanism of bioactive compounds. It is based on identifying cellular hypersensitivity and resistance caused by individual gene modulations with genome-wide coverage. Due to the requirement of bar-coded, genome-wide deletion collections, high-resolution experiments of this nature have historically been limited to fungal systems. Read More
Basic Clin Neurosci 2018 Jul-Aug;9(4):261-268. Epub 2018 Jul 1.
Department of Psychiatry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Introduction: Psychiatric disorders could be evaluated in terms of behavioral activation and inhibition systems. Dysregulation of these systems may lead to development of manic or depressive episodes in patients with mood disorders. This study aimed to identify Behavioral Approach System (BAS) and Behavioral Inhibition System (BIS) hypersensitivity as the functional brain system behaviors in patients with major depressive disorder and bipolar mood disorder I, compared to healthy individuals. Read More
Front Cell Neurosci 2018 21;12:436. Epub 2018 Nov 21.
Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, China.
To find satisfactory treatment strategies for neuropathic pain syndromes, the cellular mechanisms should be illuminated. Central sensitization is a generator of pain hypersensitivity, and is mainly reflected in neuronal hyperexcitability in pain pathway. Neuronal excitability depends on two components, the synaptic inputs and the intrinsic excitability. Read More
Nat Rev Cardiol 2018 Dec 5. Epub 2018 Dec 5.
Kardiologie I, Zentrum für Kardiologie, University Medical Center Mainz and DZHK Standort Rhein-Main, Mainz, Germany.
Stent thrombosis (ST) is a rare but severe complication of coronary procedures with high mortality, high relapse rate and a very complex pathophysiology. An individual's susceptibility to ST is multifactorial and results from interactions between clinical factors, endothelial biology, hypersensitivity and/or inflammatory reactions, blood rheology, platelet reactivity, clotting factors, physical and mechanical properties of the stent and from the effects of these different factors on the fluid dynamics of blood flow. Since the introduction of stents 32 years ago, continuous improvements in our understanding of the pathophysiology of ST have triggered important advances, including new therapies, new technologies and an increased awareness of the implications of implantation techniques. Read More
Pain 2018 Nov 29. Epub 2018 Nov 29.
Department of Pharmacology and Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242.
The complement system significantly contributes to the development of inflammatory and neuropathic pain, but the underlying mechanisms are poorly understood. Recently, we identified the signaling pathway responsible for thermal hypersensitivity induced by the complement system component C5a. Here, we examine the mechanisms of another important action of C5a, induction of mechanical hypersensitivity. Read More
Clin Exp Allergy 2018 Dec 2. Epub 2018 Dec 2.
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, United States.
Background: Rush desensitization can provide short-term tolerance to individuals who are allergic to certain medications in instances where other therapeutic interventions are limited. While rush DS is typically successful in preventing adverse type I hypersensitivity reactions, the mechanism of allergic protection remains unknown. Given the rise in prevalence of individuals displaying multiple allergies, understanding the impact of rush DS on "bystander" allergens, or additional allergens to which an individual is sensitized, could help inform clinical recommendations. Read More
Neurol Sci 2018 Dec 1. Epub 2018 Dec 1.
Department of Neurology, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu, 41944, Republic of Korea.
Objectives: This study investigated to identify the clinical significance of allodynia compared with other sensory hypersensitivities (SH) in migraine patients.
Methods: New patients with migraine were recruited from a headache clinic, and we collected data regarding their clinical characteristics and identified SH including photophobia, phonophobia, osmophobia, and allodynia. The patients completed the 12-item Allodynia Symptom Checklist, Migraine Disability Assessment Scale (MIDAS), Headache Impact Test-6 (HIT-6), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), Insomnia Severity Index (ISI), Fatigue Severity Scale (FSS), and Migraine-Specific Quality of Life Questionnaire Version 2. Read More