6,839 results match your criteria Hypersensitivity Nephropathy


Exceptional association of hypocomplementemic urticarial vasculitis syndrome (HUVS) and symptomatic pulmonary histoplasmosis: a case-based literature review.

Clin Rheumatol 2019 Apr 13. Epub 2019 Apr 13.

Departments of Medicine and Rheumatology, MetroHealth Medical Center, Cleveland, OH, USA.

Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare type III hypersensitivity disorder characterized by urticarial vasculitis and prolonged hypocomplementemia. Individuals with HUVS may also have joint involvement, pulmonary manifestations, ocular disease, kidney inflammation, or any other form of organ involvement. Hypocomplementemia, the presence of C1q antibody in the serum, and urticarial vasculitis are the keys to the diagnosis of HUVS. Read More

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http://dx.doi.org/10.1007/s10067-019-04548-8DOI Listing
April 2019
1 Read

Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity.

PLoS One 2019 4;14(4):e0214621. Epub 2019 Apr 4.

Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria, Australia.

Experimental non-human primate models of obesity are induced through the introduction of atypically calorically rich diets. Studies in captive-bred macaques show the development of obesity and diabetes with similar complications to humans including eye and kidney diseases, nerve damage associated with pain and blood vessel damage. Diets differ in outcomes and here we document inflammation of the gastrointestinal tract that can be exacerbated through these dietary interventions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214621PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448857PMC
April 2019
5 Reads

[Renal prognosis of IgA vasculitis nephritis in adult patients: a monocentric study of 25 cases].

Pan Afr Med J 2018 4;31. Epub 2018 Sep 4.

Service de Médecine Interne A, Hopital Charles Nicolle, Tunis, Tunisie.

IgA vasculitis nephritis affects the prognosis of this disease in adult patients. This study aimed to examine the clinical characteristics of this renal involvement in adults and to identify factors influencing renal prognosis. We conducted a retrospective monocentric study of patients with histologically confirmed IgA vasculitis nephritis (rheumatoid purpura) (EULAR classification criteria) with renal involvement classified according to Pillebout classification. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.9.10594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431421PMC
April 2019
1 Read

Different histological classifications for Henoch-Schönlein purpura nephritis: which one should be used?

Pediatr Rheumatol Online J 2019 Feb 28;17(1):10. Epub 2019 Feb 28.

Department of Pediatrics, Hacettepe University, Ankara, Turkey.

Background: Nephritis is the most important chronic complication of IgA Vasculitis (IgAV)/Henoch-Schönlein purpura (IGAV/HSP) and thus the main prognostic factor of this most common childhood vasculitis. Since the prognosis and treatment selection depends on the mode of interpretation of biopsy material, in this manuscript we have presented several issues related to the uneven application of different histological classifications in IgAV/Henoch-Schönlein purpura nephritis (HSPN). The nephritis of IgAV/IGAV/HSP will be abbreviated as HSPN for this paper. Read More

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http://dx.doi.org/10.1186/s12969-019-0311-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393980PMC
February 2019
1 Read

[Value of galactose-deficient IgA1 in the early diagnosis of Henoch-Schönlein purpura nephritis in children].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):172-175

Department of Nephrology and Rheumatology, Hunan Children's Hospital/Academy of Pediatrics of University of South China, Changsha 410007, China.

Objective: To explore the value of galactose-deficient IgA1 (Gd-IgA1) in the early diagnosis of Henoch-Schönlein purpura nephritis (HSPN) in children.

Methods: A total of 67 hospitalized children who were definitely diagnosed with HSPN between January and April 2018 and 58 hospitalized children with Henoch-Schönlein purpura (HSP) were enrolled in the study. Twenty children undergoing routine physical examinations served as controls. Read More

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February 2019
1 Read

Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate.

Diabetologia 2019 May 31;62(5):811-821. Epub 2019 Jan 31.

Diabetes Research Institute and Cell Transplant Center, University of Miami Miller School of Medicine, 1450 NW 10th Ave, Miami, FL, 33136, USA.

Aims/hypothesis: Patients with autoimmune type 1 diabetes transplanted with pancreatic islets to their liver experience significant improvement in quality of life through better control of blood sugar and enhanced awareness of hypoglycaemia. However, long-term survival and efficacy of the intrahepatic islet transplant are limited owing to liver-specific complications, such as immediate blood-mediated immune reaction, hypoxia, a highly enzymatic and inflammatory environment and locally elevated levels of drugs including immunosuppressive agents, all of which are injurious to islets. This has spurred a search for new islet transplant sites and for innovative ways to achieve long-term graft survival and efficacy without life-long systemic immunosuppression and its complications. Read More

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http://dx.doi.org/10.1007/s00125-019-4814-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451664PMC
May 2019
7 Reads
6.671 Impact Factor

Allopurinol and loss of consciousness in a 78-old year man suffering from gout.

Infect Disord Drug Targets 2019 Jan 27. Epub 2019 Jan 27.

Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad. Iran.

Allopurinol is an FDA-Approved xanthine oxidase inhibitor that uses in the treatment of gout, hyperuricemia and uremic kidney stones in the patients with an increased level of uric acid excretion. Xanthine oxidase acts by converting hypoxanthine and xanthine to uric acid, and therefore its inhibition will result in decreased production of uric acid. The most common side effects of this medication are as follows: maculopapular rashes, hives, itching, headache, dizziness, abnormal hair loss, fever and hypersensitivity reaction. Read More

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http://dx.doi.org/10.2174/1871526519666190128102039DOI Listing
January 2019
5 Reads

A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity.

Cell Host Microbe 2019 01 20;25(1):113-127.e6. Epub 2018 Dec 20.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA. Electronic address:

Western lifestyle is linked to autoimmune and metabolic diseases, driven by changes in diet and gut microbiota composition. Using Toll-like receptor 7 (TLR7)-dependent mouse models of systemic lupus erythematosus (SLE), we dissect dietary effects on the gut microbiota and find that Lactobacillus reuteri can drive autoimmunity but is ameliorated by dietary resistant starch (RS). Culture of internal organs and 16S rDNA sequencing revealed TLR7-dependent translocation of L. Read More

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http://dx.doi.org/10.1016/j.chom.2018.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377154PMC
January 2019
3 Reads

Angioedema of the small bowel caused by lisinopril.

Drug Ther Bull 2019 Jan;57(1):14-15

Gastroenterology, McLaren of Greater Lansing, Lansing,, Michigan, United States of America.

In conjunction with , will feature occasional drug-related cases that are likely to be of interest to readers. These will include cases that involve recently marketed drugs for which there is limited knowledge of adverse effects and cases that highlight unusual reactions to drugs that have been marketed for several years. Read More

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http://dx.doi.org/10.1136/dtb.2018.225396repDOI Listing
January 2019
4 Reads

Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.

Nat Rev Urol 2019 Mar;16(3):187-200

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, USA.

Urologic chronic pelvic pain syndrome (UCPPS), which encompasses interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, is characterized by chronic pain in the pelvic region or genitalia that is often accompanied by urinary frequency and urgency. Despite considerable research, no definite aetiological risk factors or effective treatments have been identified. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network uses a novel integrated strategy to characterize UCPPS as a systemic disorder that potentially involves multiple aetiologies. Read More

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http://www.nature.com/articles/s41585-018-0135-5
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http://dx.doi.org/10.1038/s41585-018-0135-5DOI Listing
March 2019
17 Reads

Henoch-Schönlein Purpura After Living Donor Liver Transplantation: Report of the First Case.

Transplant Proc 2018 Dec 9;50(10):4050-4052. Epub 2018 Mar 9.

Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Henoch-Schönlein purpura (HSP) is a systemic vasculitis affecting the small vessels that mainly presents in children and young adults. It is characterized by tissue deposition of immunoglobulin A (IgA) immune complexes with the classic manifestations of purpura, arthritis, arthralgia, and gastrointestinal and renal involvements. We report a case of HSP nephritis that occurred 2 years after living-donor liver transplantation (LDLT). Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.02.072DOI Listing
December 2018
3 Reads

A Fatal Case of Acute Renal Failure From Envenoming Syndrome After Massive Bee Attack: A Case Report and Literature Review.

Authors:
Rhome L Hughes

Am J Forensic Med Pathol 2019 Mar;40(1):52-57

From the University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND.

Envenoming syndrome is a systemic toxic reaction to the inoculation of large volume of insect venom, typically after a swarm attack from bees. Africanized honey bees are notorious for their aggressive nature, and human deaths resulting from Africanized honey bee attacks are consistently reported. Whereas anaphylaxis is the most common lethal mechanism of injury, delayed deaths can also occur as a consequence of severe venom toxicity with resultant end organ damage. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000451DOI Listing
March 2019
4 Reads

[Effect of miR-21 on the expression of interleukin-10 in B cell of patients with Henoch-Schonlein purpura].

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):939-944

Rheumatology & Immunology Department of Shenzhen Children's Hospital, Shenzhen 518038, China.

To investigate the effect of microRNAs (miR)-21 on the expression of interleukin (IL)-10 in B cell of patients with Henoch-Schonlein purpura (HSP). From March 2016 to January 2017, twenty-four children with HSP hospitalized in rheumatology and immunology department of Shenzhen Children's Hospital were enrolled into the study, including 12 males and 12 females. Patients were divided into purpura nephritis group (HSPN, 14 cases) and non-nephritis group (NHSPN, 10 cases). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.12.010DOI Listing
December 2018
5 Reads

The effect of herpes simplex virus vector-mediated gene therapy of protein phosphatase 1α on bladder overactivity and nociception.

Neurourol Urodyn 2019 Feb 29;38(2):582-590. Epub 2018 Nov 29.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Aims: We studied the effect of herpes simplex virus (HSV) vectors-based gene transfer of protein phosphatase 1α (PP1α) on bladder hypersensitivity in rats.

Methods: Using adult female Sprague-Dawley rats, non-replicating HSV vectors carrying PP1α or green fluorescent protein (GFP) were injected into the bladder wall. At one week after vector inoculation, cystometry and Western blot assay were performed, whereas the other experiments were performed at 2 weeks after vector inoculation. Read More

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http://dx.doi.org/10.1002/nau.23882DOI Listing
February 2019
3 Reads

Expression of DENDRIN in several glomerular diseases and correlation to pathological parameters and renal failure - preliminary study.

Diagn Pathol 2018 Nov 20;13(1):90. Epub 2018 Nov 20.

Department of Pathology, Forensic medicine and Cytology, University Hospital Centre Split, Split, Croatia.

Background: In glomerular injury dendrin translocates from the slit diaphragm to the podocyte nucleus, inducing apoptosis. We analyzed dendrin expression in IgA glomerulonephritis and Henoch Schönlein purpura (IgAN/HSP) versus in podocytopathies minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), and compared it to pathohistological findings and renal function at the time of biopsy and the last follow-up.

Methods: Twenty males and 13 females with median of age 35 years (min-max: 3-76) who underwent percutaneous renal biopsy and had diagnosis of glomerular disease (GD) were included in this retrospective study. Read More

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http://dx.doi.org/10.1186/s13000-018-0767-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247684PMC
November 2018
52 Reads

Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis.

Pediatr Clin North Am 2019 02;66(1):101-110

Department of Pediatrics, Medical University of South Carolina, 96 Jonathan Lucas Street, 428 CSB, MSC 608, Charleston, SC 29425, USA. Electronic address:

Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are common glomerulopathies in the pediatric population that deserve special attention. In some cases the primary care provider can follow the patient but others need more intensive management. Delaying this treatment can lead to worse morbidity. Read More

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http://dx.doi.org/10.1016/j.pcl.2018.08.008DOI Listing
February 2019
3 Reads

A randomized clinical trial comparing Nitrofurazone-coated and uncoated urinary catheters in kidney transplant recipients: Results from a pilot study.

Transpl Infect Dis 2019 Apr 5;21(2):e13031. Epub 2018 Dec 5.

Infectious Diseases Division, Internal Medicine Department, Universidade Federal de São Paulo, São Paulo, Brazil.

Background: Urinary tract infections are frequent complications early after kidney transplantation, and the use of antimicrobial coated catheters in settings other than transplantation has shown promising results for infection prevention. The purpose of this study was to compare the efficacy of Nitrofurazone-coated silicone urinary catheters with non-impregnated silicone urinary catheters in reducing bacteriuria and urinary tract infections in kidney transplant recipients.

Methods: This single-center study, randomized controlled trial at the Hospital do Rim, a tertiary referral center in kidney transplantation, located in São Paulo, Brazil. Read More

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http://dx.doi.org/10.1111/tid.13031DOI Listing
April 2019
6 Reads

Rituximab treatment for chronic steroid-dependent Henoch-Schonlein purpura: 8 cases and a review of the literature.

Pediatr Rheumatol Online J 2018 Nov 14;16(1):71. Epub 2018 Nov 14.

Department of Pediatrics, Division of Rheumatology, University of Alabama at Birmingham, 1600 7th Ave S, CPPN G10, Birmingham, AL, 35233, USA.

Background: Henoch-Schonlein purpura (HSP) is a small vessel vasculitis that is characterized by non-thrombocytopenic purpura, abdominal pain, arthritis, and glomerulonephritis. Typically, HSP is self-limited requiring only supportive care, but more severe cases may require corticosteroid (CS) treatment. Rarely, a subset of these patients has persistent rash, arthritis, abdominal involvement, or renal disease despite treatment with CS, or has disease recurrence on CS tapering. Read More

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https://ped-rheum.biomedcentral.com/articles/10.1186/s12969-
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http://dx.doi.org/10.1186/s12969-018-0285-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236882PMC
November 2018
36 Reads

ENHO, RXRA, and LXRA polymorphisms and dyslipidaemia, related comorbidities and survival in haemodialysis patients.

BMC Med Genet 2018 Nov 9;19(1):194. Epub 2018 Nov 9.

Department of Biochemistry and Molecular Biology, PUMS, Poznań, Poland.

Background: The energy homeostasis-associated gene (ENHO), retinoid X receptor alpha gene (RXRA), and liver X receptor alpha gene (LXRA) are involved in adipogenic/lipogenic regulation. We investigated whether single-nucleotide polymorphisms in these genes (ENHO rs2281997, rs72735260; RXRA rs749759, rs10776909, rs10881578; LXRA rs2279238, rs7120118, rs11039155) are associated with dyslipidaemia, related comorbidities and survival of haemodialysis (HD) patients also tested for T-helper (Th) cell interleukin genes (IL).

Methods: The study was carried out in 873 HD patients. Read More

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https://bmcmedgenet.biomedcentral.com/articles/10.1186/s1288
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http://dx.doi.org/10.1186/s12881-018-0708-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234788PMC
November 2018
18 Reads
2.083 Impact Factor

Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss).

Semin Respir Crit Care Med 2018 08 7;39(4):471-481. Epub 2018 Nov 7.

Department of Internal Medicine, Referral Center for Rare Systemic and Autoimmune Diseases, Hôpital Cochin, Université Paris Descartes, Paris, France.

Eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is a systemic necrotizing vasculitis of small- and medium-size vessels, characterized by asthma and blood eosinophilia. EGPA typically occurs in patients with preexisting asthma, and involves the skin, lungs, and peripheral nerves. Poor-prognosis factors (i. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1669454
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http://dx.doi.org/10.1055/s-0038-1669454DOI Listing
August 2018
27 Reads

Prolonged Treatment of Eosinophilic Erythema Annulare with Chloroquine.

Acta Dermatovenerol Croat 2018 Oct;26(3):262-263

Assoc. Prof. Suzana Ljubojević Hadžavdić, MD, PhD, Department of Dermatology and Venereology University Hospital Center Zagreb School of Medicine University of Zagreb, Šalata 4, 10000 Zagreb, Croatia;

Dear Editor,Eosinophilic annular erythema (EAE) is a rare figurate dermatitis of unknown etiology with prominent tissue eosinophilia. A 59-year-old male patient presented with a one-month history of itchy, polycyclic, annular, and partially serpiginous lesions involving the back, the gluteal region, and the extremities (Figure 1, a, b). There was no medical history of drug intake. Read More

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October 2018
46 Reads

Clinical significance of serum and mesangial galactose-deficient IgA1 in patients with IgA nephropathy.

PLoS One 2018 2;13(11):e0206865. Epub 2018 Nov 2.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.

Introduction: Galactose-deficient IgA1 (Gd-IgA1) is a critical pathogenic factor for IgA nephropathy (IgAN), but its value as a disease-specific biomarker remains controversial. We aimed to clarify the clinical significance of Gd-IgA1 in patients with IgAN.

Methods: We retrospectively reviewed 111 patients who were diagnosed with IgAN based on the findings of renal biopsies (RB) at Showa University Hospital since 2007. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206865PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214568PMC
April 2019
10 Reads

[Expression and significance of endothelial microparticles in children with Henoch-Schönlein purpura].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Oct;20(10):831-834

Children's Hospital of Zhengzhou University/Children's Hospital of Henan Province/Zhengzhou Children's Hospital/Zhengzhou Children's Critical Medical Key Laboratory, Zhengzhou 450000, China.

Objective: To study the expression and significance of endothelial microparticles (EMPs) in children with Henoch-Schönlein purpura (HSP).

Methods: A total of 100 previously untreated children with HSP were classified to Henoch-Schönlein purpura nephritis (HSPN) group (n=40) and non-nephritis group (n=60). Thirty healthy children who underwent physical examination were enrolled as control group. Read More

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October 2018
2 Reads

Membranous nephropathy followed by anti-glomerular basement disease: A case report and review of clinical presentation and treatment.

SAGE Open Med Case Rep 2018 19;6:2050313X18807621. Epub 2018 Oct 19.

Department of Nephrology, Heidelberg University Hospital, Heidelberg, Germany.

Membranous nephropathy is a common cause of nephrotic syndrome in adults and can be primary or secondary through autoimmune disease, medication, infection, or malignancy. Rapidly progressive glomerulonephritis with crescent formation is rare in patients with membranous nephropathy. Thus, in cases with rapid decline in renal function, after excluding complications such as malignant hypertension, acute hypersensitivity interstitial nephritis, and bilateral renal vein thrombosis, the simultaneous occurrence of a superimposed glomerulonephritis should be considered. Read More

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http://journals.sagepub.com/doi/10.1177/2050313X18807621
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http://dx.doi.org/10.1177/2050313X18807621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196619PMC
October 2018
13 Reads

Review: update on the management of calciphylaxis.

QJM 2019 Jan;112(1):29-34

Division of Nephrology, Department of Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.

Calciphylaxis is a disease of significant morbidity and mortality, predominantly affecting dialysis patients. The term 'calciphylaxis' was coined by Seyle et al. in 1961 to describe calcium deposition in the skin and subcutaneous soft tissue of uremic rats in response to 'triggers' (e. Read More

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https://academic.oup.com/qjmed/advance-article/doi/10.1093/q
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http://dx.doi.org/10.1093/qjmed/hcy234DOI Listing
January 2019
8 Reads

DRESS syndrome due to vemurafenib treatment: switching BRAF inhibitor to solve a big problem.

BMJ Case Rep 2018 Sep 30;2018. Epub 2018 Sep 30.

Medical Oncology, Vall d'Hebrón Hospital, Barcelona, Spain.

We present a case report of an early-onset drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) induced by vemurafenib (BRAF inhibitor) in a middle-age man affected by a metastatic, BRAF mutant melanoma who was started on first-line metastatic treatment with vemurafenib and cobimetinib.After initiating the treatment, the patient presented an extensive cutaneous rash with eosinophilia and renal impairment. Due the constellation of signs and symptoms, a diagnosis of DRESS syndrome was made which strongly contraindicated the reintroduction of vemurafenib due to its hypersensibility reaction. Read More

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http://dx.doi.org/10.1136/bcr-2018-224379DOI Listing
September 2018
22 Reads

[Behavioral and Molecular Pharmacological Study of the Role of Angiotensin II in Spinal Pain Transmission].

Authors:
Wataru Nemoto

Yakugaku Zasshi 2018 ;138(10):1235-1240

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University.

 Angiotensin (Ang) II, the main bioactive component of the renin-angiotensin system, is reported to participate in either the inhibition or the facilitation of pain transmission depending on brain area. Although Ang II is known to exist in the superficial dorsal horn of the spinal cord, the role of Ang II in spinal pain transmission remains unclear. In order to elucidate that role, we examined the effect of intrathecal administration of Ang II to mice. Read More

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https://www.jstage.jst.go.jp/article/yakushi/138/10/138_18-0
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http://dx.doi.org/10.1248/yakushi.18-00124DOI Listing
October 2018
17 Reads

Novel leptin receptor signaling mutants identify location and sex-dependent modulation of bone density, adiposity, and growth.

J Cell Biochem 2019 Mar 30;120(3):4398-4408. Epub 2018 Sep 30.

Department of Physiology, Michigan State University, East Lansing, Michigan.

Leptin, a hormone primarily produced by adipocytes, contributes to the regulation of bone health by modulating bone density, growth and adiposity. Upon leptin binding, multiple sites of the long form of the leptin receptor (LepRb) are phosphorylated to trigger activation of downstream signaling pathways. To address the role of LepRb-signaling pathways in bone health, we compared the effects of three LepRb mutations on bone density, adiposity, and growth in male and female mice. Read More

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http://dx.doi.org/10.1002/jcb.27726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336499PMC
March 2019
27 Reads

Health characteristics of patients with asthma, COPD and asthma-COPD overlap in the NHANES database.

Int J Chron Obstruct Pulmon Dis 2018 12;13:2859-2868. Epub 2018 Sep 12.

US Medical Affairs, GSK, Research Triangle Park, NC, USA,

Introduction: Asthma and COPD have overlapping characteristics. As there are limited data on whether asthma-COPD overlap (ACO) represents a distinct condition, this study aimed to determine the similarities and differences of ACO with asthma and COPD.

Methods: US population-based, cross-sectional study using National Health and Nutrition Examination Survey data (2009-2012) compared participants with ACO vs those with asthma or COPD, each as mutually exclusive disease states. Read More

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https://www.dovepress.com/health-characteristics-of-patients
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http://dx.doi.org/10.2147/COPD.S167379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143639PMC
January 2019
44 Reads

The LURN Research Network Neuroimaging and Sensory Testing (NIST) Study: Design, protocols, and operations.

Contemp Clin Trials 2018 Nov 21;74:76-87. Epub 2018 Sep 21.

Departments of Anesthesiology and Internal Medicine-Rheumatology, University of Michigan, Ann Arbor, MI, United States.

The Neuroimaging and Sensory Testing (NIST) Study of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) is a cross-sectional, case-control study designed to investigate whether disrupted brain connectivity and sensory processing are associated with abnormal lower urinary tract symptoms (LUTS) in patients with overactive bladder syndrome (OAB). The NIST Study tests the hypotheses that patients with urinary urgency will demonstrate: (1) abnormal functional and structural connectivity of brain regions involved in urinary sensation on magnetic resonance imaging (MRI), and (2) hypersensitivity to painful (pressure) and non-painful (auditory) sensory stimuli on quantitative sensory testing (QST), compared to controls. Male and female adults (18 years or older) who present at one of the six participating LURN clinical centers for clinical care of their LUTS, with symptoms of urinary urgency with or without urgency urinary incontinence, are eligible to participate. Read More

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http://dx.doi.org/10.1016/j.cct.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203612PMC
November 2018
7 Reads

Risk factors for renal involvement and severe kidney disease in 2731 Chinese children with Henoch-Schönlein purpura: A retrospective study.

Medicine (Baltimore) 2018 Sep;97(38):e12520

Department of Pediatrics.

To identify the risk factors for developing renal involvement and severe kidney disease in Chinese childhood Henoch-Schönlein purpura (HSP) patients.This was a retrospective study of 2731 children with HSP diagnosed between 2012 and 2015. We analyzed their demographic data, clinical manifestations, and laboratory tests retrospectively. Read More

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http://dx.doi.org/10.1097/MD.0000000000012520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160025PMC
September 2018
11 Reads

UBE3A Suppresses Overnutrition-Induced Expression of the Steatosis Target Genes of MLL4 by Degrading MLL4.

Hepatology 2019 Mar 7;69(3):1122-1134. Epub 2019 Feb 7.

Neuroscience Section, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health & Science University, Portland, OR.

Regulation of the protein stability of epigenetic regulators remains ill-defined despite its potential applicability in epigenetic therapies. The histone H3-lysine 4-methyltransferase MLL4 is an epigenetic transcriptional coactivator that directs overnutrition-induced obesity and fatty liver formation, and Mll4+/- mice are resistant to both. Here we show that the E3 ubiquitin ligase UBE3A targets MLL4 for degradation, thereby suppressing high-fat diet (HFD)-induced expression of the hepatic steatosis target genes of MLL4. Read More

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http://dx.doi.org/10.1002/hep.30284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393921PMC
March 2019
6 Reads

A case of Graves' disease associated with membranoproliferative glomerulonephritis and leukocytoclastic vasculitis.

J Pediatr Endocrinol Metab 2018 Oct;31(10):1165-1168

Ghent University, Department of Pediatrics and Medical Genetics, Ghent, Belgium.

Background The association of hyperthyroidism with renal disease is very rare and the importance of timely clinical recognition cannot be overemphasized. Case presentation An 11-year-old girl presented with gastrointestinal symptoms while hypertension, edema and abdominal pain were noticed on clinical examination. Laboratory investigation revealed: hemoglobin 9. Read More

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http://dx.doi.org/10.1515/jpem-2018-0186DOI Listing
October 2018
7 Reads

The influence of acute kidney injury on the outcome of Stevens-Johnson syndrome and toxic epidermal necrolysis: The prognostic value of KDIGO staging.

PLoS One 2018 7;13(9):e0203642. Epub 2018 Sep 7.

Kidney Research Center, Department of Nephrology, Change Gung Memorial Hospital, Linkou branch, Taoyuan, Taiwan.

Background: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome are severe drug-induced cutaneous adverse reactions with high mortality. Acute kidney injury (AKI) was a common complication in an SJS/TEN group and noted as an independent risk factor for mortality in patients with SJS/TEN. To determine whether AKI staging can predict the outcome of patients with SJS/TEN, we compared the discriminative power of an AKI KDIGO staging system with that of SCROTEN, APACHE II, APACHE III, and SOFA. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203642PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128626PMC
February 2019
10 Reads
3.234 Impact Factor

Ferumoxytol for the treatment of iron deficiency anemia.

Expert Rev Hematol 2018 10 14;11(10):829-834. Epub 2018 Sep 14.

c Department of Medicine , University of Virigina Health System , Charlottesville , Virignia , USA.

Introduction: Ferumoxytol is a superparamagnetic molecule originally developed as a contrast agent for magnetic resonance imaging. Elemental iron is contained within the carbohydrate core and is released slowly after infusion allowing a large dose of iron to be administered in a short period of time. Ferumoxytol, originally approved for iron deficiency in chronic kidney disease, received a broad label for any cause of iron deficiency after oral iron intolerance or in those circumstances when oral iron is ineffective or harmful. Read More

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https://www.tandfonline.com/doi/full/10.1080/17474086.2018.1
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http://dx.doi.org/10.1080/17474086.2018.1518712DOI Listing
October 2018
20 Reads

Trimethoprim-sulfamethoxazole-induced drug reaction with eosinophilia and systemic symptoms in a child with congenital renal disease.

Pediatr Dermatol 2018 Nov 6;35(6):e391-e392. Epub 2018 Sep 6.

Division of Dermatology, Department of Medicine, University of Arizona, Tucson, Arizona.

We present a special case of an 8-year-old girl diagnosed with severe drug reaction with eosinophilia and systemic symptoms due to trimethoprim-sulfamethoxazole for urinary tract infection prophylaxis for congenital vesicoureteral reflux. The patient is believed to have developed drug reaction with eosinophilia and systemic symptoms because of her underlying renal disease. Read More

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http://dx.doi.org/10.1111/pde.13607DOI Listing
November 2018
4 Reads

Investigating Serious Adverse Drug Reactions in Patients Receiving Erythropoiesis-Stimulating Agents: A Root Cause Analysis Using the "ANTICIPATE" Framework.

Am J Ther 2018 Nov/Dec;25(6):e670-e674

The Southern Network on Adverse Reactions (SONAR) Program, University of South Carolina College of Pharmacy, Columbia, SC.

Background: Unexpected serious adverse drug reactions (sADRs) affecting patients with chronic kidney disease (CKD) who received erythropoiesis-stimulating agents were identified by study co-authors. These included pure red cell aplasia (PRCA) after administration of the Eprex formulation of epoetin or the epoetin biosimilar HX575 and fatal anaphylaxis associated with peginesatide, an erythropoietin receptor agonist. We developed and applied a structured framework to describe these sADRs, including root cause analyses and eradication efforts. Read More

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http://Insights.ovid.com/crossref?an=00045391-900000000-9857
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http://dx.doi.org/10.1097/MJT.0000000000000768DOI Listing
March 2019
19 Reads

Immunogenicity and Immune Complex Disease in Preclinical Safety Studies.

Authors:
John L Vahle

Toxicol Pathol 2018 12 29;46(8):1013-1019. Epub 2018 Aug 29.

1 Lilly Research Laboratories, Indianapolis, Indiana, USA.

This article summarizes a continuing education presentation on immunogenicity that was part of a continuing education course entitled, "Clinical Pathology of Biotherapeutics." Immunogenicity of a biotherapeutic can have diverse impacts including altered systemic exposure and pharmacologic responses and, in a fraction of the cases, safety concerns including cross-reactive neutralization of endogenous proteins or sequela related to immune complex disease (ICD). In most cases, immune complexes are readily cleared from circulation; however, based on physiochemical properties, insoluble complexes form, activate complement, and deposit in tissues. Read More

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http://dx.doi.org/10.1177/0192623318797070DOI Listing
December 2018
12 Reads

Facilitation of MrgprD by TRP-A1 promotes neuropathic pain.

FASEB J 2019 Jan 27;33(1):1360-1373. Epub 2018 Aug 27.

School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, China.

Neuropathic pain remains a therapeutic challenge because of its complicated mechanisms. Mas-related GPCR D (MrgprD) is specifically expressed in small-diameter, nociceptive neurons of dorsal root ganglia (DRGs) and is implicated in pain modulation. However, the underlying mechanism of MrgprD involved in neuropathic pain remains elusive. Read More

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http://dx.doi.org/10.1096/fj.201800615RRDOI Listing
January 2019
8 Reads

Sirolimus-induced severe small bowel angioedema: A case report.

Medicine (Baltimore) 2018 Aug;97(34):e12029

Department of Pharmacy.

Rationale: Drug-induced angioedema has been reported as an adverse effect of many different drugs. But small bowel angioedema associated with sirolimus (SRL) used was barely understood. It must be necessary to report a case suffering from small bowel angioedema with detailed discussion and literature review. Read More

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http://dx.doi.org/10.1097/MD.0000000000012029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112953PMC
August 2018
19 Reads
5.720 Impact Factor

Identification of hepatotoxic and nephrotoxic potential markers of triptolide in mice with delayed-type hypersensitivity.

J Pharm Biomed Anal 2018 Oct 10;160:404-414. Epub 2018 Aug 10.

State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China. Electronic address:

Triptolide (TP) is the crucial active ingredient of Tripterygium glycoside tablets and has been shown to have a significant therapeutic effect on delayed-type hypersensitivity (DTH)-related diseases. However, due to its potential hepatotoxicity and nephrotoxicity, adverse reactions have often been observed in long-term treatment regimens. Therefore, it is meaningful to find metabolic markers for toxicity for early diagnosis. Read More

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http://dx.doi.org/10.1016/j.jpba.2018.08.018DOI Listing
October 2018
4 Reads

[Morbidity of Chronic Obstructive Pulmonary Disease in Colombia. Results of the study SANEPOC-2]

Rev Fac Cien Med Univ Nac Cordoba 2018 03 22;75(1):19-24. Epub 2018 Mar 22.

Universidad Simón Bolívar de Barranquilla, Colombia.

Objective: to relate the morbidities of patients belonging to the COPD program of a health institution in Anserma, Caldas (Colombia).

Material And Methods: a descriptive study was presented with a sample of 51 patients who underwent exploratory spirometry, the findings were contrasted with the main commodities reported by the patients or the Medical Record through descriptive and inferential statistics.

Results: 50% of the evaluated population had at least one recorded comorbidity; the main morbidity found was Arterial Hypertension followed by Chronic Kidney Disease; an associated behavior was found between the GOLD classification and the presence of symptoms with non-statistically significant values; no statistically significant association was found between comorbidities and spirometric values. Read More

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http://dx.doi.org/10.31053/1853.0605.v75.n1.16617DOI Listing
March 2018
3 Reads

[Peritoneal dialysis-related eosinophilic peritonitis: a case report and literature review].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Aug;50(4):747-751

Department of Nephrology, Peking University People's Hospital, Beijing 100044, China.

Peritoneal dialysis (PD)-related peritonitis is recognized as a common complication of peritoneal dialysis. Eosinophilic peritonitis is a rare type of non-infection PD-related peritonitis. Eosinophilic peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients was first reported in 1967. Read More

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August 2018
20 Reads

Significance of glomerular fibrinogen deposition in children with Henoch-Schönlein purpura nephritis.

Ital J Pediatr 2018 Aug 16;44(1):97. Epub 2018 Aug 16.

Department of Pathology, Soochow University Affiliated Children's Hospital, Suzhou, Jiangsu, China.

Background: Henoch-Schönlein purpura nephritis (HSPN) is the most common pediatric secondary glomerular disease. This study aimed to investigate the significance of glomerular fibrinogen (Fib) deposition in children with HSPN.

Methods: Eighty-two patients with HSPN were enrolled retrospectively at the Children's Hospital of Soochow University from January 2015 to March 2017. Read More

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http://dx.doi.org/10.1186/s13052-018-0538-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097424PMC
August 2018
12 Reads

Innate Immunity Induced by the Major Allergen Alt a 1 From the Fungus Is Dependent Upon Toll-Like Receptors 2/4 in Human Lung Epithelial Cells.

Front Immunol 2018 30;9:1507. Epub 2018 Jul 30.

Department of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.

Allergens are molecules that elicit a hypersensitive inflammatory response in sensitized individuals and are derived from a variety of sources. Alt a 1 is the most clinically important secreted allergen of the ubiquitous fungus, . It has been shown to be a major allergen causing IgE-mediated allergic response in the vast majority of -sensitized individuals. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072870PMC
January 2019
5 Reads

Drug-induced Glomerulonephritis: The Spectre of Biotherapeutic and Antisense Oligonucleotide Immune Activation in the Kidney.

Toxicol Pathol 2018 12 8;46(8):904-917. Epub 2018 Aug 8.

1 GlaxoSmithKline, King of Prussia, Pennsylvania, USA.

Prevalence of immune-mediated glomerulonephritis has increased in preclinical toxicity studies, with more frequent use of biotherapeutic agents (especially antigenic humanized molecules) and antisense oligonucleotide (ASO) therapies. Immune complex disease affects a small number of study monkeys, often correlates with antidrug antibody (ADA) titers, and occurs at a dose that favors immune complex formation or impedes clearance. While preclinical glomerulonephritis often fails to correlate with evidence of glomerular or vascular injury in human clinical trials and is not considered predictive, additional animal investigative immunohistochemical work may be performed to substantiate evidence for immune complex pathogenesis. Read More

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http://dx.doi.org/10.1177/0192623318789399DOI Listing
December 2018
12 Reads

Idiopathic immune complex-mediated tubulointerstitial nephritis with hypocomplementemia and neutrophil-rich interstitial infiltrates
.

Clin Nephrol 2018 Nov;90(5):357-362

A 69-year-old man presented with acute kidney injury, hypocomplementemia, antinuclear antibody, and anti-dsDNA antibody. He had no signs of systemic lupus erythematosus or Sjögren syndrome. He had not begun taking any new drugs in the preceding 6 months. Read More

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http://dx.doi.org/10.5414/CN109457DOI Listing
November 2018
7 Reads

Calcinosis cutis dermatologic toxicity associated with fibroblast growth factor receptor inhibitor for the treatment of Wilms tumor.

J Cutan Pathol 2018 Oct 3;45(10):786-790. Epub 2018 Aug 3.

Department of Pathology, Section of Dermatopathology, MD Anderson Cancer Center, The University of Texas, Houston, Texas.

Small-molecule inhibitors (nibs) have revolutionized cancer therapy with the emergence of clinically efficacious treatment for advanced-stage malignancies. Fibroblast growth factor receptor (FGFR) inhibitors have shown therapeutic efficacy in malignancies with molecular-genetic alterations in the FGFR/fibroblast growth factor pathway. In a phase 1 clinical trial, erdafitinib, a pan FGFR inhibitor, was well tolerated with a manageable toxicity profile. Read More

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http://dx.doi.org/10.1111/cup.13319DOI Listing
October 2018
2 Reads
1.560 Impact Factor

Resolution of sinus bradycardia, high-grade heart block, and left ventricular systolic dysfunction with rituximab therapy in Henoch-Schonlein purpura.

Intern Med J 2018 07;48(7):868-871

Albany Medical Center, Albany, New York, USA.

Henoch-Schonlein purpura (HSP) is a rare, typically self-limited, multi-organ vasculitis. Cardiac involvement with HSP carries high morbidity and mortality, thus requiring early aggressive immunosuppressive therapy. We report a case of HSP complicated with acute systolic left ventricular (LV) dysfunction, symptomatic sinus bradycardia and high-grade atrio-ventricular (AV) heart block. Read More

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http://dx.doi.org/10.1111/imj.13948DOI Listing
July 2018
4 Reads