6,810 results match your criteria Hypersensitivity Nephropathy


Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate.

Diabetologia 2019 Jan 31. Epub 2019 Jan 31.

Diabetes Research Institute and Cell Transplant Center, University of Miami Miller School of Medicine, 1450 NW 10th Ave, Miami, FL, 33136, USA.

Aims/hypothesis: Patients with autoimmune type 1 diabetes transplanted with pancreatic islets to their liver experience significant improvement in quality of life through better control of blood sugar and enhanced awareness of hypoglycaemia. However, long-term survival and efficacy of the intrahepatic islet transplant are limited owing to liver-specific complications, such as immediate blood-mediated immune reaction, hypoxia, a highly enzymatic and inflammatory environment and locally elevated levels of drugs including immunosuppressive agents, all of which are injurious to islets. This has spurred a search for new islet transplant sites and for innovative ways to achieve long-term graft survival and efficacy without life-long systemic immunosuppression and its complications. Read More

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http://dx.doi.org/10.1007/s00125-019-4814-4DOI Listing
January 2019
1 Read
6.671 Impact Factor

Hypersensitivity and cardiovascular risks related to allopurinol and febuxostat therapy in Asians: A population-based cohort study and meta-analysis.

Clin Pharmacol Ther 2019 Jan 28. Epub 2019 Jan 28.

Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospitals, Linkou, Taipei, Keelung, Taiwan.

The safety of newer xanthine oxidase inhibitor-febuxostat comparing to allopurinol remains unclear. To compare the risks of allopurinol- and febuxostat-hypersensitivity and cardiovascular diseases (CVD) in Asians, we conducted a population-based cohort study enrolling patients receiving allopurinol or febuxostat from Chang Gung Memorial Hospital Health System across Taiwan during 2012-2016 and further performed a meta-analysis incorporating two recent studies. Among the 61,539 users, a corresponding 12,007 and 5,680 patients were identified as new users. Read More

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http://doi.wiley.com/10.1002/cpt.1377
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http://dx.doi.org/10.1002/cpt.1377DOI Listing
January 2019
4 Reads
7.903 Impact Factor

Allopurinol and loss of consciousness in a 78-old year man suffering from gout.

Infect Disord Drug Targets 2019 Jan 27. Epub 2019 Jan 27.

Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad. Iran.

Allopurinol is an FDA-Approved xanthine oxidase inhibitor that uses in the treatment of gout, hyperuricemia and uremic kidney stones in the patients with an increased level of uric acid excretion. Xanthine oxidase acts by converting hypoxanthine and xanthine to uric acid, and therefore its inhibition will result in decreased production of uric acid. The most common side effects of this medication are as follows: maculopapular rashes, hives, itching, headache, dizziness, abnormal hair loss, fever and hypersensitivity reaction. Read More

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http://dx.doi.org/10.2174/1871526519666190128102039DOI Listing
January 2019
2 Reads

Angioedema of the small bowel caused by lisinopril.

Drug Ther Bull 2019 Jan;57(1):14-15

Gastroenterology, McLaren of Greater Lansing, Lansing,, Michigan, United States of America.

In conjunction with , will feature occasional drug-related cases that are likely to be of interest to readers. These will include cases that involve recently marketed drugs for which there is limited knowledge of adverse effects and cases that highlight unusual reactions to drugs that have been marketed for several years. Read More

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http://dx.doi.org/10.1136/dtb.2018.225396repDOI Listing
January 2019
3 Reads

Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.

Nat Rev Urol 2018 Dec 18. Epub 2018 Dec 18.

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, USA.

Urologic chronic pelvic pain syndrome (UCPPS), which encompasses interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, is characterized by chronic pain in the pelvic region or genitalia that is often accompanied by urinary frequency and urgency. Despite considerable research, no definite aetiological risk factors or effective treatments have been identified. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network uses a novel integrated strategy to characterize UCPPS as a systemic disorder that potentially involves multiple aetiologies. Read More

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http://www.nature.com/articles/s41585-018-0135-5
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http://dx.doi.org/10.1038/s41585-018-0135-5DOI Listing
December 2018
11 Reads

Henoch-Schönlein Purpura After Living Donor Liver Transplantation: Report of the First Case.

Transplant Proc 2018 Dec 9;50(10):4050-4052. Epub 2018 Mar 9.

Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Henoch-Schönlein purpura (HSP) is a systemic vasculitis affecting the small vessels that mainly presents in children and young adults. It is characterized by tissue deposition of immunoglobulin A (IgA) immune complexes with the classic manifestations of purpura, arthritis, arthralgia, and gastrointestinal and renal involvements. We report a case of HSP nephritis that occurred 2 years after living-donor liver transplantation (LDLT). Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.02.072DOI Listing
December 2018
1 Read

A Fatal Case of Acute Renal Failure From Envenoming Syndrome After Massive Bee Attack: A Case Report and Literature Review.

Authors:
Rhome L Hughes

Am J Forensic Med Pathol 2019 Mar;40(1):52-57

From the University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND.

Envenoming syndrome is a systemic toxic reaction to the inoculation of large volume of insect venom, typically after a swarm attack from bees. Africanized honey bees are notorious for their aggressive nature, and human deaths resulting from Africanized honey bee attacks are consistently reported. Whereas anaphylaxis is the most common lethal mechanism of injury, delayed deaths can also occur as a consequence of severe venom toxicity with resultant end organ damage. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000451DOI Listing
March 2019
3 Reads

The effect of herpes simplex virus vector-mediated gene therapy of protein phosphatase 1α on bladder overactivity and nociception.

Neurourol Urodyn 2018 Nov 29. Epub 2018 Nov 29.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Aims: We studied the effect of herpes simplex virus (HSV) vectors-based gene transfer of protein phosphatase 1α (PP1α) on bladder hypersensitivity in rats.

Methods: Using adult female Sprague-Dawley rats, non-replicating HSV vectors carrying PP1α or green fluorescent protein (GFP) were injected into the bladder wall. At one week after vector inoculation, cystometry and Western blot assay were performed, whereas the other experiments were performed at 2 weeks after vector inoculation. Read More

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http://dx.doi.org/10.1002/nau.23882DOI Listing
November 2018
2 Reads

Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis.

Pediatr Clin North Am 2019 02;66(1):101-110

Department of Pediatrics, Medical University of South Carolina, 96 Jonathan Lucas Street, 428 CSB, MSC 608, Charleston, SC 29425, USA. Electronic address:

Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are common glomerulopathies in the pediatric population that deserve special attention. In some cases the primary care provider can follow the patient but others need more intensive management. Delaying this treatment can lead to worse morbidity. Read More

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http://dx.doi.org/10.1016/j.pcl.2018.08.008DOI Listing
February 2019
2 Reads

A randomized clinical trial comparing Nitrofurazone-coated and uncoated urinary catheters in kidney transplant recipients: Results from a pilot study.

Transpl Infect Dis 2018 Nov 19:e13031. Epub 2018 Nov 19.

Infectious Diseases Division, Internal Medicine Department, Universidade Federal de São Paulo, São Paulo, Brazil.

Background: Urinary tract infections are frequent complications early after kidney transplantation, and the use of antimicrobial coated catheters in settings other than transplantation has shown promising results for infection prevention. The purpose of this study was to compare the efficacy of Nitrofurazone-coated silicone urinary catheters with non-impregnated silicone urinary catheters in reducing bacteriuria and urinary tract infections in kidney transplant recipients.

Methods: This single-center study, randomized controlled trial at the Hospital do Rim, a tertiary referral center in kidney transplantation, located in São Paulo, Brazil. Read More

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http://dx.doi.org/10.1111/tid.13031DOI Listing
November 2018
3 Reads

Rituximab treatment for chronic steroid-dependent Henoch-Schonlein purpura: 8 cases and a review of the literature.

Pediatr Rheumatol Online J 2018 Nov 14;16(1):71. Epub 2018 Nov 14.

Department of Pediatrics, Division of Rheumatology, University of Alabama at Birmingham, 1600 7th Ave S, CPPN G10, Birmingham, AL, 35233, USA.

Background: Henoch-Schonlein purpura (HSP) is a small vessel vasculitis that is characterized by non-thrombocytopenic purpura, abdominal pain, arthritis, and glomerulonephritis. Typically, HSP is self-limited requiring only supportive care, but more severe cases may require corticosteroid (CS) treatment. Rarely, a subset of these patients has persistent rash, arthritis, abdominal involvement, or renal disease despite treatment with CS, or has disease recurrence on CS tapering. Read More

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https://ped-rheum.biomedcentral.com/articles/10.1186/s12969-
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http://dx.doi.org/10.1186/s12969-018-0285-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236882PMC
November 2018
27 Reads

ENHO, RXRA, and LXRA polymorphisms and dyslipidaemia, related comorbidities and survival in haemodialysis patients.

BMC Med Genet 2018 Nov 9;19(1):194. Epub 2018 Nov 9.

Department of Biochemistry and Molecular Biology, PUMS, Poznań, Poland.

Background: The energy homeostasis-associated gene (ENHO), retinoid X receptor alpha gene (RXRA), and liver X receptor alpha gene (LXRA) are involved in adipogenic/lipogenic regulation. We investigated whether single-nucleotide polymorphisms in these genes (ENHO rs2281997, rs72735260; RXRA rs749759, rs10776909, rs10881578; LXRA rs2279238, rs7120118, rs11039155) are associated with dyslipidaemia, related comorbidities and survival of haemodialysis (HD) patients also tested for T-helper (Th) cell interleukin genes (IL).

Methods: The study was carried out in 873 HD patients. Read More

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https://bmcmedgenet.biomedcentral.com/articles/10.1186/s1288
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http://dx.doi.org/10.1186/s12881-018-0708-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234788PMC
November 2018
12 Reads
2.083 Impact Factor

Membranous nephropathy followed by anti-glomerular basement disease: A case report and review of clinical presentation and treatment.

SAGE Open Med Case Rep 2018 19;6:2050313X18807621. Epub 2018 Oct 19.

Department of Nephrology, Heidelberg University Hospital, Heidelberg, Germany.

Membranous nephropathy is a common cause of nephrotic syndrome in adults and can be primary or secondary through autoimmune disease, medication, infection, or malignancy. Rapidly progressive glomerulonephritis with crescent formation is rare in patients with membranous nephropathy. Thus, in cases with rapid decline in renal function, after excluding complications such as malignant hypertension, acute hypersensitivity interstitial nephritis, and bilateral renal vein thrombosis, the simultaneous occurrence of a superimposed glomerulonephritis should be considered. Read More

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http://journals.sagepub.com/doi/10.1177/2050313X18807621
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http://dx.doi.org/10.1177/2050313X18807621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196619PMC
October 2018
11 Reads

Review: update on the management of calciphylaxis.

QJM 2019 Jan;112(1):29-34

Division of Nephrology, Department of Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.

Calciphylaxis is a disease of significant morbidity and mortality, predominantly affecting dialysis patients. The term 'calciphylaxis' was coined by Seyle et al. in 1961 to describe calcium deposition in the skin and subcutaneous soft tissue of uremic rats in response to 'triggers' (e. Read More

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https://academic.oup.com/qjmed/advance-article/doi/10.1093/q
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http://dx.doi.org/10.1093/qjmed/hcy234DOI Listing
January 2019
7 Reads

DRESS syndrome due to vemurafenib treatment: switching BRAF inhibitor to solve a big problem.

BMJ Case Rep 2018 Sep 30;2018. Epub 2018 Sep 30.

Medical Oncology, Vall d'Hebrón Hospital, Barcelona, Spain.

We present a case report of an early-onset drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) induced by vemurafenib (BRAF inhibitor) in a middle-age man affected by a metastatic, BRAF mutant melanoma who was started on first-line metastatic treatment with vemurafenib and cobimetinib.After initiating the treatment, the patient presented an extensive cutaneous rash with eosinophilia and renal impairment. Due the constellation of signs and symptoms, a diagnosis of DRESS syndrome was made which strongly contraindicated the reintroduction of vemurafenib due to its hypersensibility reaction. Read More

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http://dx.doi.org/10.1136/bcr-2018-224379DOI Listing
September 2018
15 Reads

[Behavioral and Molecular Pharmacological Study of the Role of Angiotensin II in Spinal Pain Transmission].

Authors:
Wataru Nemoto

Yakugaku Zasshi 2018 ;138(10):1235-1240

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University.

 Angiotensin (Ang) II, the main bioactive component of the renin-angiotensin system, is reported to participate in either the inhibition or the facilitation of pain transmission depending on brain area. Although Ang II is known to exist in the superficial dorsal horn of the spinal cord, the role of Ang II in spinal pain transmission remains unclear. In order to elucidate that role, we examined the effect of intrathecal administration of Ang II to mice. Read More

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https://www.jstage.jst.go.jp/article/yakushi/138/10/138_18-0
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http://dx.doi.org/10.1248/yakushi.18-00124DOI Listing
October 2018
10 Reads

Novel leptin receptor signaling mutants identify location and sex-dependent modulation of bone density, adiposity, and growth.

J Cell Biochem 2019 Mar 30;120(3):4398-4408. Epub 2018 Sep 30.

Department of Physiology, Michigan State University, East Lansing, Michigan.

Leptin, a hormone primarily produced by adipocytes, contributes to the regulation of bone health by modulating bone density, growth and adiposity. Upon leptin binding, multiple sites of the long form of the leptin receptor (LepRb) are phosphorylated to trigger activation of downstream signaling pathways. To address the role of LepRb-signaling pathways in bone health, we compared the effects of three LepRb mutations on bone density, adiposity, and growth in male and female mice. Read More

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http://dx.doi.org/10.1002/jcb.27726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336499PMC
March 2019
17 Reads

Health characteristics of patients with asthma, COPD and asthma-COPD overlap in the NHANES database.

Int J Chron Obstruct Pulmon Dis 2018 12;13:2859-2868. Epub 2018 Sep 12.

US Medical Affairs, GSK, Research Triangle Park, NC, USA,

Introduction: Asthma and COPD have overlapping characteristics. As there are limited data on whether asthma-COPD overlap (ACO) represents a distinct condition, this study aimed to determine the similarities and differences of ACO with asthma and COPD.

Methods: US population-based, cross-sectional study using National Health and Nutrition Examination Survey data (2009-2012) compared participants with ACO vs those with asthma or COPD, each as mutually exclusive disease states. Read More

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https://www.dovepress.com/health-characteristics-of-patients
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http://dx.doi.org/10.2147/COPD.S167379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143639PMC
January 2019
33 Reads

The LURN Research Network Neuroimaging and Sensory Testing (NIST) Study: Design, protocols, and operations.

Contemp Clin Trials 2018 Nov 21;74:76-87. Epub 2018 Sep 21.

Departments of Anesthesiology and Internal Medicine-Rheumatology, University of Michigan, Ann Arbor, MI, United States.

The Neuroimaging and Sensory Testing (NIST) Study of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) is a cross-sectional, case-control study designed to investigate whether disrupted brain connectivity and sensory processing are associated with abnormal lower urinary tract symptoms (LUTS) in patients with overactive bladder syndrome (OAB). The NIST Study tests the hypotheses that patients with urinary urgency will demonstrate: (1) abnormal functional and structural connectivity of brain regions involved in urinary sensation on magnetic resonance imaging (MRI), and (2) hypersensitivity to painful (pressure) and non-painful (auditory) sensory stimuli on quantitative sensory testing (QST), compared to controls. Male and female adults (18 years or older) who present at one of the six participating LURN clinical centers for clinical care of their LUTS, with symptoms of urinary urgency with or without urgency urinary incontinence, are eligible to participate. Read More

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http://dx.doi.org/10.1016/j.cct.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203612PMC
November 2018
5 Reads

Risk factors for renal involvement and severe kidney disease in 2731 Chinese children with Henoch-Schönlein purpura: A retrospective study.

Medicine (Baltimore) 2018 Sep;97(38):e12520

Department of Pediatrics.

To identify the risk factors for developing renal involvement and severe kidney disease in Chinese childhood Henoch-Schönlein purpura (HSP) patients.This was a retrospective study of 2731 children with HSP diagnosed between 2012 and 2015. We analyzed their demographic data, clinical manifestations, and laboratory tests retrospectively. Read More

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http://dx.doi.org/10.1097/MD.0000000000012520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160025PMC
September 2018
5 Reads

UBE3A Suppresses Overnutrition-Induced Expression of the Steatosis Target Genes of MLL4 by Degrading MLL4.

Hepatology 2018 Sep 19. Epub 2018 Sep 19.

Neuroscience Section, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health & Science University, Portland, OR.

Regulation of the protein stability of epigenetic regulators remains ill-defined despite its potential applicability in epigenetic therapies. The histone H3-lysine 4-methyltransferase MLL4 is an epigenetic transcriptional coactivator that directs overnutrition-induced obesity and fatty liver formation, and Mll4+/- mice are resistant to both. Here we show that the E3 ubiquitin ligase UBE3A targets MLL4 for degradation, thereby suppressing high-fat diet (HFD)-induced expression of the hepatic steatosis target genes of MLL4. Read More

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http://dx.doi.org/10.1002/hep.30284DOI Listing
September 2018
2 Reads

A case of Graves' disease associated with membranoproliferative glomerulonephritis and leukocytoclastic vasculitis.

J Pediatr Endocrinol Metab 2018 Oct;31(10):1165-1168

Ghent University, Department of Pediatrics and Medical Genetics, Ghent, Belgium.

Background The association of hyperthyroidism with renal disease is very rare and the importance of timely clinical recognition cannot be overemphasized. Case presentation An 11-year-old girl presented with gastrointestinal symptoms while hypertension, edema and abdominal pain were noticed on clinical examination. Laboratory investigation revealed: hemoglobin 9. Read More

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http://dx.doi.org/10.1515/jpem-2018-0186DOI Listing
October 2018
5 Reads

Trimethoprim-sulfamethoxazole-induced drug reaction with eosinophilia and systemic symptoms in a child with congenital renal disease.

Pediatr Dermatol 2018 Nov 6;35(6):e391-e392. Epub 2018 Sep 6.

Division of Dermatology, Department of Medicine, University of Arizona, Tucson, Arizona.

We present a special case of an 8-year-old girl diagnosed with severe drug reaction with eosinophilia and systemic symptoms due to trimethoprim-sulfamethoxazole for urinary tract infection prophylaxis for congenital vesicoureteral reflux. The patient is believed to have developed drug reaction with eosinophilia and systemic symptoms because of her underlying renal disease. Read More

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http://dx.doi.org/10.1111/pde.13607DOI Listing
November 2018
3 Reads

Facilitation of MrgprD by TRP-A1 promotes neuropathic pain.

FASEB J 2019 Jan 27;33(1):1360-1373. Epub 2018 Aug 27.

School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, China.

Neuropathic pain remains a therapeutic challenge because of its complicated mechanisms. Mas-related GPCR D (MrgprD) is specifically expressed in small-diameter, nociceptive neurons of dorsal root ganglia (DRGs) and is implicated in pain modulation. However, the underlying mechanism of MrgprD involved in neuropathic pain remains elusive. Read More

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http://dx.doi.org/10.1096/fj.201800615RRDOI Listing
January 2019
8 Reads

Sirolimus-induced severe small bowel angioedema: A case report.

Medicine (Baltimore) 2018 Aug;97(34):e12029

Department of Pharmacy.

Rationale: Drug-induced angioedema has been reported as an adverse effect of many different drugs. But small bowel angioedema associated with sirolimus (SRL) used was barely understood. It must be necessary to report a case suffering from small bowel angioedema with detailed discussion and literature review. Read More

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http://dx.doi.org/10.1097/MD.0000000000012029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112953PMC
August 2018
12 Reads
5.720 Impact Factor

Identification of hepatotoxic and nephrotoxic potential markers of triptolide in mice with delayed-type hypersensitivity.

J Pharm Biomed Anal 2018 Oct 10;160:404-414. Epub 2018 Aug 10.

State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China. Electronic address:

Triptolide (TP) is the crucial active ingredient of Tripterygium glycoside tablets and has been shown to have a significant therapeutic effect on delayed-type hypersensitivity (DTH)-related diseases. However, due to its potential hepatotoxicity and nephrotoxicity, adverse reactions have often been observed in long-term treatment regimens. Therefore, it is meaningful to find metabolic markers for toxicity for early diagnosis. Read More

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http://dx.doi.org/10.1016/j.jpba.2018.08.018DOI Listing
October 2018
3 Reads

[Morbidity of Chronic Obstructive Pulmonary Disease in Colombia. Results of the study SANEPOC-2]

Rev Fac Cien Med Univ Nac Cordoba 2018 03 22;75(1):19-24. Epub 2018 Mar 22.

Universidad Simón Bolívar de Barranquilla, Colombia.

Objective: to relate the morbidities of patients belonging to the COPD program of a health institution in Anserma, Caldas (Colombia).

Material And Methods: a descriptive study was presented with a sample of 51 patients who underwent exploratory spirometry, the findings were contrasted with the main commodities reported by the patients or the Medical Record through descriptive and inferential statistics.

Results: 50% of the evaluated population had at least one recorded comorbidity; the main morbidity found was Arterial Hypertension followed by Chronic Kidney Disease; an associated behavior was found between the GOLD classification and the presence of symptoms with non-statistically significant values; no statistically significant association was found between comorbidities and spirometric values. Read More

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http://dx.doi.org/10.31053/1853.0605.v75.n1.16617DOI Listing
March 2018
2 Reads

Significance of glomerular fibrinogen deposition in children with Henoch-Schönlein purpura nephritis.

Ital J Pediatr 2018 Aug 16;44(1):97. Epub 2018 Aug 16.

Department of Pathology, Soochow University Affiliated Children's Hospital, Suzhou, Jiangsu, China.

Background: Henoch-Schönlein purpura nephritis (HSPN) is the most common pediatric secondary glomerular disease. This study aimed to investigate the significance of glomerular fibrinogen (Fib) deposition in children with HSPN.

Methods: Eighty-two patients with HSPN were enrolled retrospectively at the Children's Hospital of Soochow University from January 2015 to March 2017. Read More

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http://dx.doi.org/10.1186/s13052-018-0538-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097424PMC
August 2018
11 Reads

Innate Immunity Induced by the Major Allergen Alt a 1 From the Fungus Is Dependent Upon Toll-Like Receptors 2/4 in Human Lung Epithelial Cells.

Front Immunol 2018 30;9:1507. Epub 2018 Jul 30.

Department of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.

Allergens are molecules that elicit a hypersensitive inflammatory response in sensitized individuals and are derived from a variety of sources. Alt a 1 is the most clinically important secreted allergen of the ubiquitous fungus, . It has been shown to be a major allergen causing IgE-mediated allergic response in the vast majority of -sensitized individuals. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072870PMC
January 2019
4 Reads

Idiopathic immune complex-mediated tubulointerstitial nephritis with hypocomplementemia and neutrophil-rich interstitial infiltrates
.

Clin Nephrol 2018 Nov;90(5):357-362

A 69-year-old man presented with acute kidney injury, hypocomplementemia, antinuclear antibody, and anti-dsDNA antibody. He had no signs of systemic lupus erythematosus or Sjögren syndrome. He had not begun taking any new drugs in the preceding 6 months. Read More

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http://dx.doi.org/10.5414/CN109457DOI Listing
November 2018
6 Reads

Calcinosis cutis dermatologic toxicity associated with fibroblast growth factor receptor inhibitor for the treatment of Wilms tumor.

J Cutan Pathol 2018 Oct 3;45(10):786-790. Epub 2018 Aug 3.

Department of Pathology, Section of Dermatopathology, MD Anderson Cancer Center, The University of Texas, Houston, Texas.

Small-molecule inhibitors (nibs) have revolutionized cancer therapy with the emergence of clinically efficacious treatment for advanced-stage malignancies. Fibroblast growth factor receptor (FGFR) inhibitors have shown therapeutic efficacy in malignancies with molecular-genetic alterations in the FGFR/fibroblast growth factor pathway. In a phase 1 clinical trial, erdafitinib, a pan FGFR inhibitor, was well tolerated with a manageable toxicity profile. Read More

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http://dx.doi.org/10.1111/cup.13319DOI Listing
October 2018
2 Reads
1.560 Impact Factor

Resolution of sinus bradycardia, high-grade heart block, and left ventricular systolic dysfunction with rituximab therapy in Henoch-Schonlein purpura.

Intern Med J 2018 07;48(7):868-871

Albany Medical Center, Albany, New York, USA.

Henoch-Schonlein purpura (HSP) is a rare, typically self-limited, multi-organ vasculitis. Cardiac involvement with HSP carries high morbidity and mortality, thus requiring early aggressive immunosuppressive therapy. We report a case of HSP complicated with acute systolic left ventricular (LV) dysfunction, symptomatic sinus bradycardia and high-grade atrio-ventricular (AV) heart block. Read More

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http://dx.doi.org/10.1111/imj.13948DOI Listing
July 2018
3 Reads

Chronic Pruritus in the Geriatric Population.

Dermatol Clin 2018 Jul 20;36(3):199-211. Epub 2018 Mar 20.

Department of Dermatology and Cutaneous Surgery, Itch Center Miller School of Medicine, 1295 NW 14th Street, University of Miami Hospital South Building Suites K-M, Miami, FL 33125, USA.

Chronic pruritus (>6 week's duration) in the geriatric population (≥65 years old), is an increasing health care problem. The pathophysiologic predisposing factors are abnormalities of the epidermal barrier, immune system, and nervous system. Causes can be dichotomized into histaminergic and nonhistaminergic pruritus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183001
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http://dx.doi.org/10.1016/j.det.2018.02.004DOI Listing
July 2018
25 Reads
1.434 Impact Factor

Ten-year Nationwide Population-based Survey on the Characteristics of Children with Henoch-Schӧnlein Purpura in Korea.

J Korean Med Sci 2018 Jun 14;33(25):e174. Epub 2018 May 14.

Department of Pediatrics, Inje University College of Medicine, Seoul, Korea.

Background: Henoch-Schӧnlein purpura (HSP) is a common vasculitis of childhood. Though HSP is usually self-limiting, severe complications can occur. The management for this condition has not been established yet. Read More

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http://dx.doi.org/10.3346/jkms.2018.33.e174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000599PMC
June 2018
4 Reads

Chinese herbal medicine for the treatment of Henoch-Schönlein purpura nephritis in children: A prospective cohort study protocol.

Medicine (Baltimore) 2018 Jun;97(24):e11064

Affiliated Hospital of Liaoning University of Traditional Chinese Medicine.

Introduction: Henoch-Schönlein purpura nephritis (HSPN) involves the renal impairment of Henoch-Schönlein purpura and can easily relapse into life-threatening late nephropathy in severe cases. Although there is a lack of validated evidence for its effectiveness, Chinese herbal medicine (CHM) is one of the most commonly used methods in China to treat HSPN. It is thus need to report the protocol of a prospective cohort trial using CHM to investigate the effectiveness, safety and advantages for children with HSPN. Read More

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http://dx.doi.org/10.1097/MD.0000000000011064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024032PMC
June 2018
14 Reads
5.720 Impact Factor

IgA nephropathy with leucocytoclastic vasculitis.

J Int Med Res 2018 Jul 10;46(7):3009-3014. Epub 2018 Jun 10.

1 Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Leucocytoclastic vasculitis is a rare type of allergic disease caused by immune complexes. IgA nephropathy is a glomerulopathy characterized by recurrent episodes of gross haematuria or microscopic haematuria and IgA deposition in the glomerular mesangial region. IgA nephropathy complicating leucocytoclastic vasculitis is rare documented. Read More

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http://dx.doi.org/10.1177/0300060518775814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124258PMC
July 2018
1 Read

Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats.

Diabetes Metab J 2018 Aug 25;42(4):338-342. Epub 2018 Apr 25.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.

The effect of sodium-glucose cotransporter 2 inhibitors on peripheral nerves and kidneys in diabetes mellitus (DM) remains unexplored. Therefore, this study aimed to explore the effect of empagliflozin in diabetic rats. DM in rats was induced by streptozotocin injection, and diabetic rats were treated with empagliflozin 3 or 10 mg/kg. Read More

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http://dx.doi.org/10.4093/dmj.2017.0095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107360PMC
August 2018
10 Reads

[Tubulointerstitial Nephritis (Drug-Induced, Inflammatory)].

Dtsch Med Wochenschr 2018 06 28;143(11):802-805. Epub 2018 May 28.

Medizinische Klinik III (Nieren- und Hochdruckkrankheiten), Klinikum Bamberg.

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http://dx.doi.org/10.1055/a-0511-8458DOI Listing
June 2018
4 Reads

Distinct characteristics and outcomes in elderly-onset IgA vasculitis (Henoch-Schönlein purpura) with nephritis: Nationwide cohort study of data from the Japan Renal Biopsy Registry (J-RBR).

PLoS One 2018 8;13(5):e0196955. Epub 2018 May 8.

Division of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa, Japan.

Background: The clinical presentation and prognosis of adult and elderly patients with IgA vasculitis (Henoch-Schönlein purpura) accompanied by nephritis (IgAV-N) have not been investigated in detail. We therefore surveyed the features and outcomes of IgAV-N based on nationwide data derived from the Japan Renal Biopsy Registry (J-RBR).

Methods: This multi-center cohort study compared the clinicopathological parameters at diagnosis, initial therapies and outcomes between 106 adult (age 19-64 years) and 46 elderly (≥65 years) patients with IgAV-N who were registered in the J-RBR between 2007 and 2012. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196955PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940189PMC
August 2018
4 Reads

Ureterosciatic hernia treated with ureteral stent placement.

BMJ Case Rep 2018 May 4;2018. Epub 2018 May 4.

Urology, Kanazawa Medical University, Kahoku-gun, Japan.

A 92-year-old female with a history of asthma and chronic heart failure presented with left lumber back pain. Physical examination revealed knocking tenderness at the left costal-vertebral angle. Laboratory test results were within normal limits. Read More

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http://dx.doi.org/10.1136/bcr-2017-222908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935149PMC
May 2018
5 Reads

S1P₄ Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells.

Int J Mol Sci 2018 Apr 25;19(5). Epub 2018 Apr 25.

Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.

Mast cells are key players in the development of inflammatory allergic reactions. Cross-linking of the high-affinity receptor for IgE (FcεRI) on mast cells leads to the generation and secretion of the sphingolipid mediator, sphingosine-1-phosphate (S1P) which is able, in turn, to transactivate its receptors on mast cells. Previous reports have identified the expression of two of the five receptors for S1P on mast cells, S1P₁ and S1P₂, with functions in FcεRI-mediated chemotaxis and degranulation, respectively. Read More

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http://dx.doi.org/10.3390/ijms19051279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983835PMC
April 2018
11 Reads

Clinical Profile and Outcome of Paraphenylene Diamine Poisoning.

J Coll Physicians Surg Pak 2018 May;28(5):374-377

Department of Medical Unit, Nishtar Hospital, Multan.

Objective: To determine the clinical presentation, complications, and outcome of paraphenylene diamine (PPD) poisoning in patients presenting to Nishtar Hospital, Multan.

Study Design: Descriptive study.

Place And Duration Of Study: Medical Unit II and III, Nishtar Hospital, Multan, from April 2015 to September 2016. Read More

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http://dx.doi.org/10.29271/jcpsp.2018.05.374DOI Listing
May 2018
15 Reads

Xp11 translocation renal cell carcinoma paraneoplastic syndrome presenting as cutaneous vasculitis: first reported case of yet another mask.

BMJ Case Rep 2018 Apr 21;2018. Epub 2018 Apr 21.

Department of Urology, Austin Health, Heidelberg, Victoria, Australia.

Renal cell carcinoma is historically known as the 'great masquerader' with 40% of patients experiencing a paraneoplastic syndrome. Translocation carcinoma represents one-third of renal cancer in paediatric patients but less than 3% of renal cancers in patients aged 18-45 years where the clinical course is often rapidly terminal. There are less than 10 reported cases of leucoclastic vasculitis associated with clear cell carcinoma reported in the literature and 10 case reports of translocation carcinoma in adults. Read More

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http://dx.doi.org/10.1136/bcr-2017-223423DOI Listing
April 2018
7 Reads

Henoch Schönlein Purpura Nephritis Developing in a Child with Known IgA Nephropathy.

Indian J Pediatr 2018 09 6;85(9):808-809. Epub 2018 Apr 6.

Fortis Institute of Renal Transplantation Sciences, Fortis Hospital, Vasant Kunj, New Delhi, India.

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http://dx.doi.org/10.1007/s12098-018-2660-xDOI Listing
September 2018
9 Reads
0.920 Impact Factor

Löfgren syndrome as secondary autoimmune disease in a patient with B-cell depletion following rituximab treatment.

Clin Exp Rheumatol 2018 May-Jun;36(3):515-516. Epub 2018 Mar 21.

Central Institute for Medical and Chemical Laboratory Diagnostics, Medical University Innsbruck, Austria.

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July 2018
13 Reads

A can't miss diagnosis for rash in a peritoneal dialysis patient.

Intern Emerg Med 2018 08 9;13(5):799-800. Epub 2018 Mar 9.

Division of Nephrology, Hypertension and Renal Transplantation, Department of Medicine, University of Florida, P.O. Box 100224, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1007/s11739-018-1825-yDOI Listing
August 2018
3 Reads

Relationship Between Abdominal Symptoms and Fructose Ingestion in Children with Chronic Abdominal Pain.

Dig Dis Sci 2018 05 7;63(5):1270-1279. Epub 2018 Mar 7.

Abteilung für Gastroenterologie und Hepatologie, Universitätsklinik für Innere Medizin 3, Medical University of Vienna, Währinger Gürtel 18 - 20, 1090, Vienna, Austria.

Background: Limited valid data are available regarding the association of fructose-induced symptoms, fructose malabsorption, and clinical symptoms.

Aim: To develop a questionnaire for valid symptom assessment before and during a carbohydrate breath test and to correlate symptoms with fructose breath test results in children/adolescents with functional abdominal pain.

Methods: A Likert-type questionnaire assessing symptoms considered relevant for hydrogen breath test in children was developed and underwent initial validation. Read More

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http://dx.doi.org/10.1007/s10620-018-4997-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895692PMC
May 2018
6 Reads

Eosinophilic Esophagitis: an Important Comorbid Condition of Asthma?

Clin Rev Allergy Immunol 2018 Aug;55(1):56-64

Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Eosinophilic esophagitis and asthma are frequently found as comorbid conditions in children and adults along with other manifestations of atopic diathesis. These two conditions have similar T helper 2 responses-driven pathophysiology and share common management strategies such as using systemic corticosteroids and targeted anti-cytokine biologic therapies. Review of the literature finds that asthma is often a comorbid condition in eosinophilic esophagitis in both children and adults; however, the EoE-asthma relationship remains poorly characterized mechanistically and clinically. Read More

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http://dx.doi.org/10.1007/s12016-018-8670-7DOI Listing
August 2018
6 Reads

Epidemiology of primary systemic vasculitis in children: a population-based study from southern Sweden.

Scand J Rheumatol 2018 07 7;47(4):295-302. Epub 2018 Feb 7.

d Department of Rheumatology, Clinical Sciences Lund , Lund University , Lund , Sweden.

Objectives: To estimate the annual incidence rate of paediatric primary systemic vasculitis (PSV) in a defined geographical area in southern Sweden.

Methods: Potential cases of PSV [IgA vasculitis (IgAV, Henoch-Schönlein purpura), Kawasaki disease (KD), granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA), polyarteritis nodosa (PAN), and Takayasu's arteritis (TAK)] were identified in a comprehensive regional healthcare register. The study area is Skåne, the southernmost county of Sweden (population 1. Read More

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http://dx.doi.org/10.1080/03009742.2017.1412497DOI Listing
July 2018
14 Reads