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Vaccines (Basel) 2020 May 9;8(2). Epub 2020 May 9.

Department of Dermatology, University Hospital Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland.

： Insect bite hypersensitivity (IBH) is an eosinophilic allergic dermatitis of horses caused by type I/IVb reactions against mainly bites. The vaccination of IBH-affected horses with equine IL-5 coupled to the Cucumber mosaic virus-like particle (eIL-5-CuMV) induces IL-5-specific auto-antibodies, resulting in a significant reduction in eosinophil levels in blood and clinical signs. the preclinical and clinical safety of the eIL-5-CuMV vaccine. Read More

J Clin Endocrinol Metab 2020 Jul;105(7)

Clinical Endocrine Section, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.

Background: Primary insulin hypersecretion predicts type 2 diabetes (T2DM) independent of insulin resistance. Enhanced β-cell glucose responsivity contributes to insulin hypersecretion. African Americans (AAs) are at a higher risk for T2DM than non-Hispanic Whites (NHWs). Read More

Pain 2020 May 4. Epub 2020 May 4.

Dept. of Neuroscience, Psychology, Drug Research and Child Health - Neurofarba - Division of Pharmacology and Toxicology, 50139 Florence, Italy.

Pharmacological tools for chronic visceral pain management are still limited and inadequate. A3 adenosine receptor (A3AR) agonists are effective in different models of persistent pain. Recently their activity has been related to the block of N-type voltage-gated Ca channels (Cav2. Read More

Zhongguo Zhen Jiu 2020 Feb;40(2):199-202

Department of Acupuncture and Moxibustion, Affiliated Hospital of Jiangxi University of TCM, Nanchang 330006, China.

The academic thought of professor - on "no allergy without any deficiency" was explored. Theory and the clinical application were elaborated on allergic diseases treated with heat-sensitive moxibustion. It is believed that the critical pathogenesis of allergic diseases is deficiency, particularly the deficiency of the lung, the spleen and the kidney. Read More

Ann Hematol 2020 Apr 6;99(4):737-741. Epub 2020 Feb 6.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

For patients with pure red cell aplasia (PRCA), cyclosporine (CsA) is the first line therapy. Occasionally, some patients who suffer from renal insufficiency cannot tolerate CsA. To explore the efficacy and tolerance of sirolimus treatment for those patients, twelve PRCA patients with renal insufficiency from May 2014 to May 2018 in Peking Union Medical College Hospital were enrolled, treated with sirolimus, and followed up at the median time of 16 (10-50) months. Read More

J Smooth Muscle Res 2019 ;55(0):81-107

Department of Physiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

In the past few decades, solid evidence has been accumulated for the pivotal significance of immunoinflammatory processes in the initiation, progression, and exacerbation of many diseases and disorders. This groundbreaking view came from original works by Ross who first described that excessive inflammatory-fibroproliferative response to various forms of insult to the endothelium and smooth muscle of the artery wall is essential for the pathogenesis of atherosclerosis (Ross, Nature 1993; 362(6423): 801-9). It is now widely recognized that both innate and adaptive immune reactions are avidly involved in the inflammation-related remodeling of many tissues and organs. Read More

Expert Rev Gastroenterol Hepatol 2020 Feb 23;14(2):113-125. Epub 2020 Jan 23.

Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

: Multiple studies have revealed a strong relationship between the development of nephropathy and hepatitis B virus (HBV) infection. The underlying pathogenesis of hepatitis B-related glomerulonephritis (HBV-GN) involves immune complexes, which can be isolated from kidney tissues. Clearance of HBV antigenemia improves renal impairment and proteinuria in HBV-GN patients. Read More

Acta Derm Venereol 2020 01;100(2):adv00024

Chronic itch is a burdensome clinical problem that often accompanies pathological dry skin-based conditions, such as atopic dermatitis, and systemic disorders, such as kidney diseases, with an unclear pathomechanism and treatments. One of the basic mouse models to investigate mechanisms of itch associated with dry skin is a mixture of acetone and ether followed by water. Animal studies using the acetone and ether followed by water model have revealed that many mediators and receptors, e. Read More

Pan Afr Med J 2019 23;34:107. Epub 2019 Oct 23.

Service de Médecine Interne, CHU Hédi Chaker, Sfax, Tunisie.

Henoch-Schonlein purpura (HSP) is a small-vessel vasculitis secondary to IgA deposits. We conducted a retrospective study of 14 cases of HSP in adults based on EULAR/PRINTO/PRES classification criteria for HSP over a period of 18 years (1996 to 2014) in Department of Internal Medicine at the Hedi Chaker University Hospital, Sfax, South Tunisia. The purpose of our study was to highlight the epidemiological, clinical, therapeutic and evolutionary features of HSP in our adult patients. Read More

Curr Opin Rheumatol 2020 Mar;32(2):134-139

Academic Rheumatology, School of Medicine, University of Nottingham, Nottingham City Hospital.

Purpose Of Review: This review discusses the findings of recently published translational research studies that have the potential to directly impact on the management of gout patients.

Recent Findings: Recent research suggests that treat-to-target urate-lowering treatment (ULT) alongside individualized education about gout, and shared decision making results in excellent adherence with ULT and prevents gout flares in the long term. Such interventions should preferentially be delivered face-to-face rather than remotely. Read More

G Ital Nefrol 2019 Dec 9;36(6). Epub 2019 Dec 9.

Dipartimento di Medicina Interna, ospedale Santa Marta e Santa Venera, Via Caronia Acireale, Catania, Italia.

We report here the case of a 63-year-old man, diagnosed with rheumatoid arthritis, who presented fever, weakness, diarrhea, chest, limbs and face erythema 20 days after starting of therapy with salazopyrin; these symptoms only partially and temporarily subsided after early drug withdrawal. The subsequent intake of mesalazine during acute colitis, after 48 hours, determined a sever relapse characterized by high fever, general malaise, diffuse morbilliform rash on the trunk, face and limbs with visceral involvement (acute renal and hepatic injury). At this time the diagnosis of "Drug reaction with eosinophilia and systemic symptoms", or DRESS, was done according to "Regiscar" criteria. Read More

Rheumatology (Oxford) 2019 12;58(Suppl 7):vii17-vii28

Division of Digestive Diseases, Faculty of Medicine, Imperial College London, UK.

Immune check point inhibitor (CPI) therapy has revolutionized treatment paradigms for several cancers, but at the cost of triggering a diverse spectrum of immune-mediated injury to non-cancer tissues. The complex biology of these toxicities remains incompletely understood, partly because tissue acquisition from affected areas can be challenging to retrieve, thus hindering development of targeted therapy. Here, we review the literature describing pathology of immune-mediated tissue lesions including gastrointestinal, skin, rheumatic, pulmonary, cardiac, renal and hepatic lesions and highlight key immunological insights. Read More

Lakartidningen 2019 Nov 29;116. Epub 2019 Nov 29.

Institutionen för Kliniska vetenskaper, Reumatologi, Lunds universitet och Reumatologkliniken, Skånes universitetssjukhus - Lund, Sweden Institutionen för Kliniska vetenskaper, Reumatologi, Lunds universitet och Reumatologkliniken, Skånes universitetssjukhus - Lund, Sweden.

Although more than 45 years have passed since hypocomplementemic urticarial vasculitis (HUVS) was first described by McDuffie and colleagues at the Mayo clinic, data on epidemiology, disease outcomes, prognosis and clinical features are scarce. Recently, we published the first epidemiological study of HUVS including data on incidence, prevalence, disease outcomes, prognosis and clinical features using data from two separate Swedish regions during a period of 16 years. The estimation of incidence and prevalence rates indicates that HUVS is rare but not always benign. Read More

Pediatr Rheumatol Online J 2019 Nov 21;17(1):75. Epub 2019 Nov 21.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pediatric Highly Intensive Care Unit, 20122, Milan, Italy.

Background: Henoch-Schönlein Purpura (HSP) is the most common vasculitis of childhood and affects the small blood vessels. Pulmonary involvement is a rare complication of HSP and diffuse alveolar hemorrhage (DAH) is the most frequent clinical presentation. Little is known about the real incidence of lung involvement during HSP in the pediatric age and about its diagnosis, management and outcome. Read More

Clin J Am Soc Nephrol 2019 02 31;14(2):250-260. Epub 2019 Jan 31.

Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, Sydney, Australia.

Background And Objectives: Higher fruit and vegetable intake is associated with lower cardiovascular and all-cause mortality in the general population. It is unclear whether this association occurs in patients on hemodialysis, in whom high fruit and vegetable intake is generally discouraged because of a potential risk of hyperkalemia. We aimed to evaluate the association between fruit and vegetable intake and mortality in hemodialysis. Read More

Ren Fail 2019 Nov;41(1):1016-1020

Department of Pediatrics, Fujian Provincial Hospital, Fujian Medical University Shengli Clinical Medical College, Fuzhou, China.

To explore the association of obesity with the occurrence of Henoch-Schönlein Purpura Nephritis (HSPN) and development of end-stage renal disease (ESRD) in children with Henoch-Schönlein Purpura (HSP). This was a retrospective study of 446 pediatric patients with diagnosed HSP. All patients' demographic characteristics, clinical features, and laboratory data were collected from the electronic medical records in hospitals from January 2008 to December 2014, and the prognosis was followed up till December 2018. Read More

Curr Pharm Des 2019 ;25(36):3799-3812

Allergy and Clinical Immunology Department, Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal.

Severe delayed drug hypersensitivity reactions comprise different clinical entities and can involve different immune-mediated mechanisms. Common examples are severe cutaneous adverse reactions and druginduced internal organ injuries. The incidence of such reactions is overall low but seems to be on the rise reaching numbers as high as 9 per million individuals-years in the case of SJS/TEN and DRESS. Read More

BMJ Open 2019 11 3;9(11):e033718. Epub 2019 Nov 3.

Surgery, The University of Melbourne, Melbourne, Victoria, Australia.

Introduction: Resistant Gram-positive organisms, such as methicillin-resistant staphylococci, account for a significant proportion of infections following joint replacement surgery. Current surgical antimicrobial prophylaxis guidelines recommend the use of first-generation or second-generation cephalosporin antibiotics, such as cefazolin. Cefazolin, however, does not prevent infections due to these resistant organisms; therefore, new prevention strategies need to be examined. Read More

Int Immunopharmacol 2020 01 20;78:105935. Epub 2019 Oct 20.

Food, Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), M.G. Marg, Post Box No. 80, Lucknow 226001, India. Electronic address:

Zhongguo Dang Dai Er Ke Za Zhi 2019 Oct;21(10):955-959

Department of Pediatrics, Harrison International Peace Hospital, Hengshui, Hebei 053000, China.

Objective: To study the clinical effect and safety of double filtration plasmapheresis (DFPP) combined with double pulse therapy with methylprednisolone (MP) and cyclophosphamide (CTX) in the treatment of children with severe Henoch-Schönlein purpura nephritis (HSPN).

Methods: A total of 60 children with severe HSPN who were admitted to the hospital from January 2014 to March 2018 were enrolled and were randomly divided into an observation group and a control group (n=30 each). In addition to routine treatment, the children in the control group were given MP+CTX pulse therapy. Read More

Toxicol Lett 2019 Dec 13;317:110-119. Epub 2019 Oct 13.

Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui, China. Electronic address:

Trichloroethylene (TCE), a commonly used industrial solvent and degreasing agent, is known to cause trichloroethylene hypersensitivity syndrome (THS) with multi-system damage, including skin, liver and kidney. Clinical evidence have shown that the kidney injury occurs in THS and our previous studies suggested that the terminal complement complex C5b-9 deposited in impaired renal tubules induced by TCE with unclear mechanisms. In the present study, we questioned whether activation of the complement system with renal deposition of C5b-9 contributes to TCE-induced kidney injury in THS. Read More

Ann Allergy Asthma Immunol 2020 01 10;124(1):97-98. Epub 2019 Oct 10.

Pulmonary Critical Care, University Hospitals Cleveland Medical Center, Cleveland, Ohio; Allergy Immunology Associates Inc, Mayfield Heights, Ohio.

PLoS One 2019 1;14(10):e0223218. Epub 2019 Oct 1.

Department of Nephrology, Children's Hospital, Chongqing Medical University, Chongqing, China.

Objective: To identify risk factors associated with unfavorable outcomes in children with IgA vasculitis with nephritis (Henoch-Schőnlein purpura nephritis)(IgA-VN).

Methods: PubMed, Embase, and Web of Science databases were searched for studies, published in English through February 2019. The data were extracted to perform pooled analysis, heterogeneity testing, subgroup analysis, sensitivity analysis, and publication bias analysis. Read More

Pediatr Dermatol 2019 Nov 30;36(6):843-853. Epub 2019 Sep 30.

Department of Dermatology, St George Hospital, Sydney, NSW, Australia.

Background: Cyclosporine is a useful immunosuppressive agent for achieving disease control in moderate to severe atopic dermatitis in children and adults. However, it carries the potential for nephrotoxicity. Monitoring of drug levels is performed in other patient groups, such as transplant recipients, but is not commonplace in the management of atopic dermatitis. Read More

Clin Exp Nephrol 2019 Dec 29;23(12):1382-1390. Epub 2019 Aug 29.

Department of Nephrology, Beijing Children's Hospital, Capital Medical University, Beijing, 100045, China.

Background: There is controversy over whether IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephritis (HSPN) are the same diseases. This study focuses on the clinicopathological comparison between HSPN and IgAN in children.

Methods: Children with IgAN and HSPN who had a diagnostic renal biopsy were enrolled. Read More

Trials 2019 Aug 29;20(1):538. Epub 2019 Aug 29.

Pediatric Kidney Disease Center, the First Affiliated Hospital of Henan University of TCM, Zhengzhou, China.

Background: Henoch-Schönlein purpura nephritis (HSPN) is the most common secondary glomerular disease in children. Currently, the treatment for HSPN is always selected based on the Kidney Disease Improving Global Outcomes guidelines; however, this approach may lead to undertreatment, especially in patients with persistent proteinuria that does not reach nephrotic levels and/or hematuria and those with a pathological classification between grades 1 and 3 according to the International Study of Kidney Disease in Children. This study was performed to evaluate the curative effect and safety of a traditional Chinese medicine (TCM) integrated treatment program in this type of HSPN. Read More

Medicine (Baltimore) 2019 Aug;98(34):e16958

The 2nd Department of Pulmonary Disease in TCM, The Key Unit of SATCM Pneumonopathy Chronic Cough and Dyspnea, Beijing Key Laboratory of Prevention and Treatment of Allergic Diseases with TCM (No. BZ0321), Center of Respiratory Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases.

Background: Asthma is a complex disease associated with many factors such as immunologic, environmental, genetic, and other factors. Common medicines used to treat asthma include β-agonist and glucocorticoid. However, in the long-term treatment, the effect of the above-mentioned drugs is not satisfactory, so many patients choose oral Chinese medicines instead of western medicines. Read More

BMC Vet Res 2019 Aug 20;15(1):303. Epub 2019 Aug 20.

Istituto Veterinario di Novara, Strada Provinciale 9, 28060 Granozzo con Monticello (NO), Novara, Italy.

Background: Chronic kidney disease (CKD) has typically a non-immune mediated origin in cats and immune-complex glomerulonephritis (ICGN) is scarcely described. Aims of this study were to characterize ICGN by light and electron microscopy and identify associations with clinico-pathological findings. In addition, comparisons between cats with ICGN and non immune-complex glomerulonephritis (non-ICGN) were performed. Read More

Niger J Clin Pract 2019 Aug;22(8):1157-1162

Department of Pediatric Dentistry, Faculty of Dentistry, Suleyman Demirel University, Isparta, Turkey.

Background: The aims of this study are to present sociodemographic and familial characteristics, clinical and systemic findings, dental treatment needs, and concomitant dental anomalies in patients with amelogenesis imperfecta (AI) and to evaluate time-varying conditions in these long-term follow-up patients.

Materials And Methods: Records of patients with AI who were examined in the Department of Pediatric Dentistry between 1999 and 2017 were reviewed. Information about sociodemographic characteristics, history of AI and consanguinity in family, systemic conditions, reasons for referral to the clinic, oral hygiene habits and gingival health, occlusion findings, and performed treatments were gathered. Read More