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Cell Physiol Biochem 2018 Dec 6;51(5):2098-2110. Epub 2018 Dec 6.

Background/aims: Bortezomib (BTZ) is largely used as a chemotherapeutic agent for the treatment of multiple myeloma. However, one of the significant limiting complications of BTZ is painful peripheral neuropathy during BTZ therapy. The purpose of this study was to examine the underlying mechanisms leading to neuropathic pain induced by BTZ. Read More

Acta Med Port 2018 Nov 30;31(11):618-623. Epub 2018 Nov 30.

Serviço de Imunoalergologia. Centro Hospitalar de São João. Porto. Portugal.

Introduction: Hymenoptera venom allergy is associated with significant morbidity and deterioration in health-related quality of life, and risk of fatal systemic reactions. Although venom immunotherapy is safe and the only effective treatment in allergic individuals, some patients prefer not to pursue this treatment. Since 2011, when the 50% reimbursement was stopped, patients must fully support the cost of immunotherapy. Read More

J Neurotrauma 2018 Dec 6. Epub 2018 Dec 6.

Emory University School of Medicine, 12239, Department of Physiology , 615 Michael Street , Atlanta, Georgia, United States , 30322 ;

Previously, we showed that noxious stimulation of the tail produces numerous detrimental effects after spinal cord injury (SCI), including an earlier onset and increased magnitude of mechanical hypersensitivity. Expanding on these observations, this study sought to determine whether localized peripheral inflammation similarly impacts the expression of mechanical hypersensitivity after SCI. Adult rats received a moderate contusion injury at thoracic level (Tl0) or sham surgery, and were administered complete Freund's adjuvant (CFA) or vehicle in one hind paw 24 hours later. Read More

J Vet Intern Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Clinical Research, University of Bern, Berne, Switzerland.

Background: Genetic, epidemiologic, and clinical evidence suggests that, in horses, there are manifestations of hypersensitivity that can occur together.

Objectives: To investigate whether concurrent insect bite hypersensitivity (IBH) and severe equine asthma (EA) is associated with higher allergen-specific and total serum immunoglobulin E (IgE) concentrations than only EA or IBH.

Animals: Healthy control horses (C, n = 40), horses with IBH (IBH, n = 24), severe EA (EA, n = 18), and both conditions (IBH/EA, n = 23) were included. Read More

Contact Dermatitis 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, Hospital Universitario Príncipe de Asturias, Madrid, Spain.

Upper eyelid gold weight implants are an established tool in the symptomatic treatment of lagophthalmos, the inability to close your eyes completely. Complications associated to this procedure are infrequent. When noted, non-infectious inflammatory reactions corresponding to type IV hypersensitivity reactions are resolved with the removal of the implant. Read More

Anaesthesia 2018 Dec 5. Epub 2018 Dec 5.

Department of Anaesthesia and Peri-operative Medicine, Monash University, Melbourne, Vic., Australia.

The proportion of patients receiving intravenous gelatin-based colloids has increased in the last decade due to safety concerns about starch-based products. Recent research suggests hypersensitivity reactions to intravenous gelatin-based solutions occur at similar rates per administration as non-depolarising neuromuscular blocking agents such as rocuronium (6.2/100,000 administrations). Read More

Methods Mol Biol 2019 ;1888:153-174

Novartis Institutes for BioMedical Research, Cambridge, MA, USA.

Chemogenomic profiling is a powerful and unbiased approach to elucidate pharmacological targets and the mechanism of bioactive compounds. It is based on identifying cellular hypersensitivity and resistance caused by individual gene modulations with genome-wide coverage. Due to the requirement of bar-coded, genome-wide deletion collections, high-resolution experiments of this nature have historically been limited to fungal systems. Read More

Basic Clin Neurosci 2018 Jul-Aug;9(4):261-268. Epub 2018 Jul 1.

Department of Psychiatry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Psychiatric disorders could be evaluated in terms of behavioral activation and inhibition systems. Dysregulation of these systems may lead to development of manic or depressive episodes in patients with mood disorders. This study aimed to identify Behavioral Approach System (BAS) and Behavioral Inhibition System (BIS) hypersensitivity as the functional brain system behaviors in patients with major depressive disorder and bipolar mood disorder I, compared to healthy individuals. Read More

Front Cell Neurosci 2018 21;12:436. Epub 2018 Nov 21.

Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, China.

To find satisfactory treatment strategies for neuropathic pain syndromes, the cellular mechanisms should be illuminated. Central sensitization is a generator of pain hypersensitivity, and is mainly reflected in neuronal hyperexcitability in pain pathway. Neuronal excitability depends on two components, the synaptic inputs and the intrinsic excitability. Read More

Nat Rev Cardiol 2018 Dec 5. Epub 2018 Dec 5.

Kardiologie I, Zentrum für Kardiologie, University Medical Center Mainz and DZHK Standort Rhein-Main, Mainz, Germany.

Stent thrombosis (ST) is a rare but severe complication of coronary procedures with high mortality, high relapse rate and a very complex pathophysiology. An individual's susceptibility to ST is multifactorial and results from interactions between clinical factors, endothelial biology, hypersensitivity and/or inflammatory reactions, blood rheology, platelet reactivity, clotting factors, physical and mechanical properties of the stent and from the effects of these different factors on the fluid dynamics of blood flow. Since the introduction of stents 32 years ago, continuous improvements in our understanding of the pathophysiology of ST have triggered important advances, including new therapies, new technologies and an increased awareness of the implications of implantation techniques. Read More

Pain 2018 Nov 29. Epub 2018 Nov 29.

Department of Pharmacology and Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242.

The complement system significantly contributes to the development of inflammatory and neuropathic pain, but the underlying mechanisms are poorly understood. Recently, we identified the signaling pathway responsible for thermal hypersensitivity induced by the complement system component C5a. Here, we examine the mechanisms of another important action of C5a, induction of mechanical hypersensitivity. Read More

Clin Exp Allergy 2018 Dec 2. Epub 2018 Dec 2.

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, United States.

Background: Rush desensitization can provide short-term tolerance to individuals who are allergic to certain medications in instances where other therapeutic interventions are limited. While rush DS is typically successful in preventing adverse type I hypersensitivity reactions, the mechanism of allergic protection remains unknown. Given the rise in prevalence of individuals displaying multiple allergies, understanding the impact of rush DS on "bystander" allergens, or additional allergens to which an individual is sensitized, could help inform clinical recommendations. Read More

Neurol Sci 2018 Dec 1. Epub 2018 Dec 1.

Department of Neurology, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu, 41944, Republic of Korea.

Objectives: This study investigated to identify the clinical significance of allodynia compared with other sensory hypersensitivities (SH) in migraine patients.

Methods: New patients with migraine were recruited from a headache clinic, and we collected data regarding their clinical characteristics and identified SH including photophobia, phonophobia, osmophobia, and allodynia. The patients completed the 12-item Allodynia Symptom Checklist, Migraine Disability Assessment Scale (MIDAS), Headache Impact Test-6 (HIT-6), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), Insomnia Severity Index (ISI), Fatigue Severity Scale (FSS), and Migraine-Specific Quality of Life Questionnaire Version 2. Read More

Clin Oral Investig 2018 Nov 30. Epub 2018 Nov 30.

Special Laboratory of Lasers in Dentistry (LELO), Department of Restorative Dentistry, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, São Paulo, SP, 05508-000, Brazil.

Aim: This double-blind, placebo-controlled, randomized clinical trial evaluated the effectiveness of Nd:YAG laser and a calcium sodium phosphosilicate-containing paste (NovaMin®) in the treatment of cervical dentin hypersensitivity (CDH).

Materials And Methods: Seventy patients were randomly allocated into the following experimental groups: control-placebo, calcium sodium phosphosilicate paste (NovaMin®), and Nd:YAG laser (1 W, 10 Hz, 85 J/cm). Pain was evaluated by means of a visual analog pain scale (VAS) after evaporative stimulation with a jet of air and tactile stimulation with an exploratory probe, before treatment (baseline) and after 5 min, 1week, and 4 weeks. Read More

Front Pediatr 2018 16;6:327. Epub 2018 Nov 16.

Department of Pediatrics, School of Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.

Rapid, precise diagnosis of Epstein-Barr virus-associated T lymphocyte or natural killer cell lymphoproliferative diseases is clinically important to prevent disease progression and avoid fatal outcomes for patients. In addition to detecting increased copy numbers of Epstein-Barr virus, identification of the lymphocyte subpopulation targeted by the virus infection is crucial to reaching the final diagnosis. However, these procedures are laborious and require large amounts of sample. Read More

Indian J Dermatol 2018 Nov-Dec;63(6):509-511

Department of Dermatology, Consorcio Hospital General Universitario de Valencia, Valencia, Spain.

Nodular secondary syphilis results from the hematogenous and lymphatic dissemination of spirochetes. Clinically, the lesions appear as partially infiltrated plaques or red-violaceous nodules, which can be solitary or multiple. Several hypotheses have been put forward to explain the formation of these infiltrated or granulomatous lesions. Read More

Neuropsychopharmacology 2018 Dec 1. Epub 2018 Dec 1.

Laboratory on the Neurobiology of Compulsive Behaviors, National Institute on Alcohol Abuse and Alcoholism, Intramural Research Program, NIH, Bethesda, MD, USA.

Vulnerability for cocaine abuse in humans is associated with low dopamine D2 receptor (D2R) availability in the striatum. The mechanisms driving this vulnerability are poorly understood. In this study, we found that downregulating D2R expression selectively in striatal indirect-pathway neurons triggers a multitude of changes in D1 receptors (D1R)-expressing direct-pathway neurons, which comprise the other main subpopulation of striatal projection neurons. Read More

Med Mycol J 2018 ;59(4):E63-E70

Medical Mycology Research Center, Chiba University.

Stress responses and pathogenicity have been extensively studied in Aspergillus fumigatus, the main causative pathogen of life-threatening aspergillosis. The heterogeneity in this pathogen's biology has recently attracted increasing attention. In the present work, we used 16 clinically isolated strains to investigate several properties relevant to the pathogenicity of A. Read More

Allergol Immunopathol (Madr) 2018 Nov 29. Epub 2018 Nov 29.

Universidad Autónoma del Estado de México, Centro de Investigación en Ciencias Médicas, Estado de México, Jesús Carranza No. 205, Colonia Universidad, Toluca de Lerdo, Estado de México, C.P. 50130, Mexico.

Background: The prevalence of food allergy is on the rise on a global scale.

Objective: To determine the prevalence of food hypersensitivity (FHS) and probable food allergy (PFA), as well as the foods and factors associated with these occurrences.

Methods: A cross-sectional study was carried out among 1992 adolescents (aged 15-18 years). Read More

Toxicology 2018 Nov 29. Epub 2018 Nov 29.

Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka City, Shizuoka, 422-8526, Japan. Electronic address:

The prevalence of skin allergies could be partly due to the increased exposure to chemicals from consumer products. Chemicals that can enhance hypersensitivity caused by other chemicals are the focus of this study. We have demonstrated that phthalate esters with short chain alcohols enhance fluorescein isothiocyanate (FITC)-induced contact hypersensitivity (CHS) in a mouse model. Read More

Gynecol Oncol 2018 Nov 29. Epub 2018 Nov 29.

Division of Gynecologic Oncology, Department of Obstetrics/Gynecology, The Ohio State University College of Medicine, Columbus, OH 43220, USA. Electronic address:

Objectives: Platinum hypersensitivity reactions (HSR) affect approximately 5% of the general oncologic population. Here we report the efficacy and safety of outpatient platinum desensitization protocol (PD) in gynecologic oncology patients with moderate (high-risk) to severe platinum HSR.

Methods: This is a retrospective report of patients with gynecologic malignancies undergoing an outpatient PD for moderate (high-risk) to severe platinum HSR from 2011 to 2017. Read More

Int J Food Sci Nutr 2018 Dec 2:1-6. Epub 2018 Dec 2.

d Fuji Oil Holdings Inc , Research Institute for Creating Future , Izumisano , Osaka , Japan.

Soymilk is rich in phytochemicals such as soy isoflavones (SIs) and soyasaponins (SSs). Dietary SIs and SSs display inhibitory effects on contact hypersensitivity (CHS), which was reported in a mouse model for allergic contact dermatitis (ACD); however, the beneficial effects of soymilk consumption on CHS remain unknown. Here, we studied the effects of drinking soymilk on CHS and gut microbiota. Read More

Int Arch Allergy Immunol 2018 Dec 5:1-7. Epub 2018 Dec 5.

Background: Most children diagnosed with β-lactam allergy based only on history are not truly allergic, and mislabeling leads to use of less effective and more costly alternative broader-spectrum antibiotics, significantly increasing drug resistance.

Objective: To determine the frequency and risk factors of confirmed allergy in patients with β-lactam allergy reported by parents or their doctors and evaluate cross-reactivity between β-lactams in children with confirmed allergy.

Method: Sixty-seven children with suspected β-lactam allergy were evaluated via history, sIgE measurements, skin tests, and drug provocation tests over a period of 5 years. Read More

Acta Cir Bras 2018 Nov;33(11):954-963

Assistant Professor, Department of Anesthesiology and Reanimation, Medical Faculty, Canakkale Onsekiz Mart University, Turkey. Analysis and interpretation of data.

Purpose: The effect of a prophylactic oleuropein-rich diet before anesthesia accompanied by the widely-used steroid-based neuromuscular drug rocuronium on mast cell activation was investigated in the study.

Methods: 14 rabbits used in the study. The rabbits in the oleuropein group were given oleuropein-rich extract added to the animals' water at doses of 20 mg/kg oleuropein for 15 days orally. Read More

JBJS Rev 2018 Dec 4. Epub 2018 Dec 4.

Department of Orthopaedic Surgery, NYU Langone Orthopaedic Hospital, New York, NY.

Liver Int 2018 Dec 4. Epub 2018 Dec 4.

Department of Dermatology, St. John's Medical College Hospital, Bangalore, India.

While dermatologic manifestations of adverse drug reactions are frequent, drug-induced liver injury is rare. Numerous drugs are implicated in either Drug-Induced Liver Injury or Drug-Induced Skin Injury. However, concomitant Drug-Induced Liver Injury and Drug-Induced Skin Injury are uncommon, not well characterized and appear to be caused by a limited number of drugs. Read More

Allergy 2018 Dec 4. Epub 2018 Dec 4.

Servicio de Neumología, Departamento de Medicina, Hospital Universitario Vall d'Hebron, Universidad Autónoma de Barcelona, Cataluña, España.

Introduction: The objective of this study was to analyze mortality, possible predictors of long-term survival and health-related quality of life of a large chronic hypersensitivity pneumonitis (CHP) patient sample.

Methods: Longitudinal study in patients diagnosed with CHP during 2004-2013, followed for at least one year. Patients remaining alive and consenting to participate had a follow-up visit during 2015, including a complete pulmonary function study and the EuroQol-5D and Beck Depression and Anxiety Inventories. Read More

Int J Cancer 2018 Dec 4. Epub 2018 Dec 4.

Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Oxaliplatin, which is widely used as chemotherapy for certain solid cancers, frequently causes peripheral neuropathy. Commonly described neuropathic symptoms include aberrant sensations such as mechanical allodynia (hypersensitivity to normally innocuous stimuli). Although oxaliplatin neuropathy is a dose-limiting toxicity, there are no established preventive strategies available at present. Read More

Oncotarget 2018 Nov 6;9(87):35762-35779. Epub 2018 Nov 6.

Department of Pharmaceutical Biology, Johannes Gutenberg University, Mainz, Germany.

Nimbolide is considered a promising natural product in cancer prevention and treatment. However, it is not known yet, whether the different mechanisms of multidrug resistance (MDR) influence its anticancer activity. In this study, well-known MDR mechanisms (, , 5, , ) were evaluated against nimbolide. Read More

Med Arch 2018 Oct;72(4):276-279

Department of Dermatovenereology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.

Background: Allergic contact dermatitis (ACD) is a delayed type of hypersensitivity from contact with a specific allergen to which the patients has developed a specific sensitivity. The aim of the study was to evaluate the results of epicutaneous patch testing with standard series of contact allergen in patients suspected to have ACD.

Methods: 355 cases of ACD were included in the study. Read More

Proc Natl Acad Sci U S A 2018 Dec 4. Epub 2018 Dec 4.

Shanghai Center for Plant Stress Biology and Center of Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, 200032 Shanghai, China;

The perception and relay of cell-wall signals are critical for plants to regulate growth and stress responses, but the underlying mechanisms are poorly understood. We found that the cell-wall leucine-rich repeat extensins (LRX) 3/4/5 are critical for plant salt tolerance in The LRXs physically associate with the RAPID ALKALINIZATION FACTOR (RALF) peptides RALF22/23, which in turn interact with the plasma membrane-localized receptor-like protein kinase FERONIA (FER). The triple mutant as well as mutant plants display retarded growth and salt hypersensitivity, which are mimicked by overexpression of / Salt stress promotes S1P protease-dependent release of mature RALF22 peptides. Read More

BMC Plant Biol 2018 Dec 4;18(1):329. Epub 2018 Dec 4.

Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China.

Background: CC-type glutaredoxins (GRXs) are plant-specific glutaredoxin, play regulatory roles in response of biotic and abiotic stress. However, it is not clear whether the CC-type GRXs are involve in drought response in cassava (Manihot esculenta), an important tropical tuber root crop.

Results: Herein, genome-wide analysis identified 18 CC-type GRXs in the cassava genome, of which six (namely MeGRXC3, C4, C7, C14, C15, and C18) were induced by drought stress in leaves of two cassava cultivars Argentina 7 (Arg7) and South China 124 (SC124). Read More

J Allergy Clin Immunol Pract 2018 Dec 1. Epub 2018 Dec 1.

Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address:

Background: Hypersensitivity reactions (HSRs) are immunologic responses to drugs. Identification of HSRs documented in the electronic health record (EHR) is important for patient safety.

Objective: To examine HSR epidemiology using longitudinal EHR data from a large United States healthcare system. Read More

J Pain 2018 Dec 1. Epub 2018 Dec 1.

Center for Neuroplasticity and Pain (CNAP), SMI, Aalborg University, Denmark. Electronic address:

Intramuscular injection of nerve growth factor (NGF) causes muscle hyperalgesia without immediate pain. This double-blinded, randomized study assessed pain and muscle hypersensitivity after a single-site bolus NGF injection (5µg) compared with five spatially distributed, low-dose NGF injections (1µg, 4cm distance) into the tibialis anterior (TA) muscles in 20 healthy subjects. Injection-pain was rated on a visual analogue scale (VAS). Read More

South Med J 2018 Dec;111(12):716-720

From the Division of Emergency Medicine, Washington University School of Medicine, St Louis, Missouri, the Division of Emergency Medicine, Duke University, Durham, North Carolina, the Department of Emergency Medicine, East Carolina University Brody School of Medicine, Greenville, North Carolina, the Department of Emergency Medicine, Virginia Commonwealth University, Richmond, the Department of Emergency Medicine, Baylor College of Medicine, Houston, Texas, the Department of Emergency Medicine, University of North Carolina, Chapel Hill, North Carolina, Texas A&M Health Sciences Center, Bryan, Rocky Mountain Poison & Drug Center, Denver, Colorado, the Department of Emergency Medicine, UT Southwestern Medical Center, Dallas, Texas, the Department of Emergency Medicine, Augusta University, Augusta, Georgia, the Department of Emergency Medicine, University of Virginia, Charlottesville, the Department of Surgery, East Carolina University Brody School of Medicine, Greenville, North Carolina, and the Department of Surgery, Marshall University, Huntington, West Virginia.

Objective: To compare the incidence of hypersensitivity reactions following copperhead envenomation treated with Fab antivenom (FabAV) or placebo.

Methods: Patients with copperhead snakebites received treatment and follow-up in a prospective, randomized, double-blind, placebo-controlled trial of FabAV or placebo. The treatment allocation ratio was 2:1 (FabAV:placebo). Read More

Radiology 2018 Dec 4:182146. Epub 2018 Dec 4.

Department of Radiology, St Marianna University School of Medicine, Kawasaki, Japan.

Cancer Chemother Pharmacol 2018 Dec 3. Epub 2018 Dec 3.

Department of Surgical Oncology, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite, France.

Background: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) shows encouraging results for patients with unresectable peritoneal metastasis. Several reports demonstrated the safety of the procedure combined with systemic chemotherapy, with a low rate of complication. The aim of this study is to report severe hypersensitivity reactions to platinum compounds (SHRPC) during PIPAC procedures. Read More

Data Brief 2018 Dec 26;21:1504-1507. Epub 2018 Oct 26.

Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russian Federation.

This data article is related to the research article entitled "Assessment of structurally modified plant virus as a novel adjuvant in toxicity studies" (Nikitin et al., 2018), devoted to the safety study of structurally modified plant virus - spherical particles (SPs). SPs are generated by thermally denatured tobacco mosaic virus (TMV) coat protein and act as effective adjuvant for development of new vaccine candidates. Read More

J Pain Res 2018 19;11:2905-2913. Epub 2018 Nov 19.

Pharmacology and Toxicology Section, Department of Neuroscience, Psychology, Drug Research, and Child Health (Neurofarba), University of Florence, Florence, Italy,

Purpose: Current pharmacotherapy for persistent pain related to neuropathy or articular diseases is unsatisfactory, due to the large number of unresponsive patients and side effects. Isothiocyanates (ITCs) are a class of natural or synthetic compounds characterized by the general formula R-NCS. ITCs show antihyperalgesic effects in models of central and peripheral nervous tissue injury and anti-inflammatory properties. Read More

J Neurogastroenterol Motil 2018 Dec 3. Epub 2018 Dec 3.

Gastrointestinal Unit, Center of Neuroenteric Health, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Gastroparesis and functional dyspepsia are 2 of the most common gastric neuromuscular disorders. These disorders are usually confused, having both similarities and differences. The pathophysiology of these disorders involves abnormal gastric motility, visceral hypersensitivity, mucosal inflammation, and various cellular changes. Read More

Pain Physician 2018 Nov;21(6):E633-E642

Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chong Qing, China.

Background: The blood-brain barrier (BBB) is an important anatomical structure of the central nervous system (CNS) that limits the penetration of a variety of substances from the blood into the parenchyma. Dysfunction of the BBB is involved in various CNS disorders, including stroke, inflammation, and pain. However, the evidence concerning its role in migraine is insufficient. Read More

Neurourol Urodyn 2018 Nov 29. Epub 2018 Nov 29.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Aims: We studied the effect of herpes simplex virus (HSV) vectors-based gene transfer of protein phosphatase 1α (PP1α) on bladder hypersensitivity in rats.

Methods: Using adult female Sprague-Dawley rats, non-replicating HSV vectors carrying PP1α or green fluorescent protein (GFP) were injected into the bladder wall. At one week after vector inoculation, cystometry and Western blot assay were performed, whereas the other experiments were performed at 2 weeks after vector inoculation. Read More

Trials 2018 Nov 29;19(1):662. Epub 2018 Nov 29.

Department of Korean Preventive Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, Republic of Korea.

Background: This study aims to evaluate the safety, efficacy, and feasibility of a full randomized clinical trial of Ojeok-san in Korean female patients with cold hypersensitivity in the hands and feet.

Methods: This study is a multicenter, double-blinded, randomized, placebo-controlled, two-arm, parallel-group pilot clinical trial. A total of 60 participants will be enrolled and randomly assigned to the Ojeok-san treatment group or the placebo control group, in a 1:1 ratio using an Internet-based randomization system. Read More

J Neurotrauma 2018 Nov 29. Epub 2018 Nov 29.

Emory University School of Medicine, 12239, Department of Physiology , 615 Michael Street , Atlanta, Georgia, United States , 30322 ;

Respiratory complications frequently accompany spinal cord injury (SCI), and slowed breathing has been shown to mitigate pain sensitivity. It is possible that elevated respiratory rates (RRs) signal the emergence of chronic pain after SCI. We previously validated the use of remote electric field sensors to non-invasively track breathing in freely behaving rodents. Read More

Pediatr Hematol Oncol 2018 Nov 29:1-10. Epub 2018 Nov 29.

b Department of Research , Sir Ganga Ram Hospital , New Delhi , India.

Background: Pegylated asparaginase (P-Asp) though integral to acute lymphoblastic leukemia (ALL) therapy is often not accessible to patients in developing countries. We share our clinical experience with generic P-Asp along with monitoring of asparaginase activity.

Methods: In this prospective observational study, patients ≤18 years of age with ALL were assigned to receive either generic P-Asp or native asparaginase (N-Asp) in a non-randomized manner. Read More

Ital J Pediatr 2018 Nov 28;44(1):143. Epub 2018 Nov 28.

Krankenhaus der Barmherzigen Brüder, Trier, Germany.

Corticosteroids are widely used for the treatment of allergic reactions but paradoxically themselves may induce acute, delayed, local or systemic allergic reactions and even anaphylaxis with Kounis syndrome. They can suppress the release of arachidonic acid from mast cell membranes, via phospholipase A2 and eicosanoid biosynthesis inhibition. Corticosteroids can promote cell apoptosis and mediate in annexin or lipocortin synthesis, substances that modulate inflammatory cell activation, adhesion molecule expression, transmigratory and phagocytic functions. Read More

J Clin Med 2018 Nov 27;7(12). Epub 2018 Nov 27.

Department of Food Safety/Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.

Hexavalent chromium (Cr(VI)) is widely used in many industries but can induce contact dermatitis especially in cement industries. Many cement workers suffer from Cr(VI)-induced allergic contact dermatitis (ACD), and prevention and therapeutic strategies are still lacking. Pterostilbene (PT) is a natural compound predominantly found in blueberries. Read More

Int Arch Allergy Immunol 2018 Nov 28:1-8. Epub 2018 Nov 28.

Clinical Pharmacology Department, Institute of Biology, CHU Nantes, Nantes, France.

Background: Proton pump inhibitors (PPIs) can trigger immediate-type hypersensitivity reactions (HSRs). Three main patterns of cross-reactivity have been identified: reactions to a single PPI, selective cross-reactions, and cross-reactions with all PPIs. Several hypotheses have been advanced, but no consensus has been reached. Read More

Glia 2018 Nov 28. Epub 2018 Nov 28.

Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan.

Microglia, which are pathological effectors and amplifiers in the central nervous system, undergo various forms of activation. A well-studied microglial-induced pathological paradigm, spinal microglial activation following peripheral nerve injury (PNI), is a key event for the development of neuropathic pain but the transcription factors contributing to microglial activation are less understood. Herein, we demonstrate that MafB, a dominant transcriptional regulator of mature microglia, is involved in the pathology of a mouse model of neuropathic pain. Read More

Contact Dermatitis 2018 Nov 28. Epub 2018 Nov 28.

Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Nankoku, Kochi, Japan.

Drug-induced hypersensitivity syndrome (DIHS) or drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, severe skin disease with manifestations such as fever, eosinophilia, lymphadenopathy and internal organ damage that typically develops 2 to 6 weeks after drug intake. DRESS/DIHS follows a prolonged course involving frequent flare-ups and relapses over weeks or months after treatment discontinuation. Read More