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    1 OF 132

    The efficacy of medical treatment in patients with acromegaly in clinical practice.
    Endocr J 2017 Sep 20. Epub 2017 Sep 20.
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
    Although somatostatin analogues (SSAs) are recommended as the first-line medical therapy for acromegaly, dopamine agonists (DAs) are also a therapeutic option for treatment. We aimed to assess and compare the efficacies of DAs and SSAs in treating acromegaly in clinical practice. We included 89 patients with acromegaly who took DAs (bromocriptine [BCT], n = 63; cabergoline [CAB], n = 11) or SSAs (n = 15) as a primary medical therapy for more than 3 months in the Seoul National University Hospital. Read More

    Steroids administered after vacuum-assisted biopsy in the management of idiopathic granulomatous mastitis.
    J Clin Pathol 2017 Oct 17;70(10):827-831. Epub 2017 Mar 17.
    Department of Pathology, Affiliated Calmaette Hospital of Kunming Medical University, Kunming, Yunnan, PR China.
    Aims: The aetiology and treatment options for idiopathic granulomatous mastitis (IGM) are controversial. The aim was to study the clinical and diagnostic features and discuss medical and surgical treatment for IGM in our patients.

    Methods: Sixty-five patients who met the histological criteria for IGM were retrospectively studied. Read More

    Resolution of dopamine agonist-resistant hyperprolactinemia by hysterectomy: a case report.
    Gynecol Endocrinol 2017 Sep 19:1-3. Epub 2017 Sep 19.
    a Department of Obstetrics and Gynecology , Hyogo Prefectural Amagasaki General Medical Center , Amagasaki , Japan.
    Prolactin-producing uterine leiomyomas are very rare. Although hyperprolactinemia rapidly improves after removal of such leiomyomas, no preoperative diagnostic test has been established for prolactin-producing uterine leiomyomas. A 45-year-old Japanese woman, gravida 3 para 3, was referred to our hospital for further examination of hyperprolactinemia resistant to a dopamine agonist. Read More

    Hypogonadotropic hypogonadism in human immunodeficiency virus-infected men: uncommonly low testosterone levels.
    Endocrinol Diabetes Metab Case Rep 2017 6;2017. Epub 2017 Sep 6.
    Endocrinology, Diabetes and Metabolism Department, Hospital de Santa Maria, Lisbon, Portugal.
    Hypogonadotropic hypogonadism (HH) is common and occurs prematurely in HIV-infected men. However, HH with very low testosterone has not been described. Three men with normal pubertal development and HIV1 diagnosis at the ages of 22, 34 and 35 years. Read More

    [Prolactin-secreting microadenoma in menopausal women].
    Pan Afr Med J 2017 5;27:177. Epub 2017 Jul 5.
    Service d'Endocrinologie, CHU Farhat Hached de Sousse, Tunisie.
    Prolactin-secreting adenoma is rare in elderly women. Patient's clinical picture may be confused with that of menopause, making diagnosis sometimes difficult. We report the case of a 57-year old woman with a 2-year history of secondary amenorrhea without hot flushes associated with galactorrhea in order to highlight the peculiarities of prolactin-secreting microadenomas. Read More

    Antipsychotic-induced hyperprolactinemia: synthesis of world-wide guidelines and integrated recommendations for assessment, management and future research.
    Psychopharmacology (Berl) 2017 Sep 9. Epub 2017 Sep 9.
    The Monash Alfred Psychiatry Research Centre, Monash University, Level 4, 607 St Kilda Rd, Melbourne, 3004, Victoria, Australia.
    Rationale: Hyperprolactinemia is a highly prevalent adverse effect of many antipsychotic agents, with potentially serious health consequences. Several guidelines have been developed for the management of this condition; yet, their concordance has not been evaluated.

    Objectives: The objectives of this paper were (1) to review current clinical guidelines; (2) to review key systematic evidence for management; and (3) based on our findings, to develop an integrated management recommendation specific to male and female patients who are otherwise clinically stabilised on antipsychotics. Read More

    [The relationship between autoimmune thyroiditis and pregnancy outcomes of patients with PCOS following in vitro fertilization and embryo transfer IVF-ET].
    Zhonghua Yi Xue Za Zhi 2017 Sep;97(33):2609-2613
    Center of Reproductive Medicine, Peking University Third Hospital, Beijing 100191, China.
    Objective: To investigate the impact of autoimmune thyroiditis (AIT) on pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) following the in vitro fertilization and embryo transfer (IVF-ET) by analyzing their pregnancy outcomes. Methods: The patients undergoing IVF-ET treatment diagnosed with PCOS in Peking University Third Hospital from May 2010 to December 2014 were investigated. According to the anti-thyroid antibodies (TPOAb or TGAb), patients were divided into AIT group and non-AIT group. Read More

    Incidental neuronal intermediate filament inclusion pathology: unexpected biopsy findings in a 37-year old woman with epilepsy.
    Neuropathol Appl Neurobiol 2017 Sep 7. Epub 2017 Sep 7.
    Neurology Department, Hospital Germans Trias i Pujol Badalona, Universitat de Barcelona, Spain.
    We present unexpected neuropathological findings in a 37 year old woman who underwent surgery for removal of an epidermoid cyst. A first brain MRI at the age of 27 years (due to hyperprolactinemia) showed a cystic lesion in the right prepontine region involving the cisterna ambiens with supratentorial extension. The lesion remained stable until she was 32 year, when it increased in size causing partial compression of the parahippocampal gyrus, midbrain peduncle and lateral pons (Fig. Read More

    Efficacy of Combined Cabergoline and Metformin Compared to Metformin Alone on Cycle Regularity in Patients with Polycystic Ovarian Disease with Hyperprolactinemia: A Randomized Clinical Trial.
    J Obstet Gynaecol India 2017 Oct 24;67(5):363-369. Epub 2017 Jun 24.
    Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
    Purpose: Polycystic ovarian syndrome (PCOS) is a common reproductive disorder. Increasing serum prolactin in these patients could be detected in both follicular and luteal phase of the normal and stimulated cycles. Hyperprolactinemia affects the hypothalamic-pituitary-ovarian axis causing anovulation and abnormal uterine bleeding. Read More

    Corynebacterium kroppenstedtii Is an Emerging Cause of Mastitis Especially in Patients With Psychiatric Illness on Antipsychotic Medication.
    Open Forum Infect Dis 2017 6;4(2):ofx096. Epub 2017 May 6.
    Queen Mary Hospital, Hong Kong.
    This retrospective study of patients with Corynebacterium kroppenstedtii infections revealed a predominance of mastitis and a potential association with psychiatric illnesses. At least one third of our patients with C kroppenstedtii mastitis had psychiatric illness, and >92% received antipsychotic medications. Drug-induced hyperprolactinemia may be an important modifiable risk factor in these patients. Read More

    Idiopathic granulomatous mastitis associated with hyperprolactinemia: A nonoperative approach.
    Breast J 2017 Aug 27. Epub 2017 Aug 27.
    Redcliffe Hospital, Redcliffe, QLD, Australia.
    There is increasing evidence associating idiopathic granulomatous mastitis (IGM) with hyperprolactinemia. All documented cases have involved the patient having at least one operative procedure before the association has been made. We present a 55 year old female with IGM associated with risperidone induced hyperprolactinemia. Read More

    Screening for valve disease in patients with hyperprolactinaemia disorders prescribed cabergoline: a service evaluation and literature review.
    Ther Adv Drug Saf 2017 Jul 25;8(7):215-229. Epub 2017 Apr 25.
    Cardiac Unit, Raigmore Hospital, NHS Highland, Old Perth Road, Inverness IV2 3UJ, UK.
    Objectives: The indication for screening for valvular heart disease in patients taking cabergoline is based on evidence from patients with Parkinson's disease on high-dose medication. However, current patients take much lower doses for indications such as hyperprolactinaemia disorders. Contemporary guidelines for echocardiogram monitoring in patients taking cabergoline are conflicting. Read More

    Vasculogenic hyperprolactinemia: severe prolactin excess in association with internal carotid artery aneurysms.
    Pituitary 2017 Aug 21. Epub 2017 Aug 21.
    Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia.
    Purpose: Internal carotid artery (ICA) aneurysms have rarely been found in association with marked hyperprolactinemia in the absence of prolactinoma; the cause of hyperprolactinemia has never been investigated. We aimed to determine if the observed hyperprolactinemia is due to a vascular-derived or known prolactin secretagogue from the injured ICA, analogous to pregnancy-associated hyperprolactinemia putatively due to placental factors.

    Methods: We conducted a case series and literature review of individuals with severe hyperprolactinemia in association with ICA aneurysms. Read More

    An Intact Dopamine Sensitivity in the Brain: A Necessity to Recover Hyperprolactinemia and Galactorrhea in a Female Hemodialysis Patient?
    Case Rep Nephrol 2017 16;2017:3729629. Epub 2017 Jul 16.
    Department of Endocrinology, University Hospital of Antwerp, Edegem, Belgium.
    A female hemodialysis patient with galactorrhea due to hyperprolactinemia was treated with different dialysis modalities to assess the effect on prolactin levels. A single session of both high-flux hemodialysis and hemodiafiltration resulted in decreased prolactin levels (16,6% and 77,2%, resp.). Read More

    DIAGNOSIS OF ENDOCRINE DISEASE: Primary Empty Sella: a comprehensive review.
    Eur J Endocrinol 2017 Aug 5. Epub 2017 Aug 5.
    L De Marinis, Pituitary Unit, Department of Endocrinology, Catholic University of the Sacred Heart, Agostino Gemelli Foundation, Rome, Italy
    Primary empty sella (PES) is characterized by the herniation of the subarachnoid space within the sella, which is often associated with variable degree of flattening of the pituitary gland in patients without previous pituitary pathologies. PES pathogenetic mechanism are not well known but seem due to a sellar diaphragm incompetence, associated to the occurrence of upper sellar or pituitary factors, as intracranial hypertension and change of pituitary volume. As PES represents in majority of cases a neuroradiological findings, without any clinical implication, the occurrence of endocrine, neurological and opthalmological symptoms, due to the above describes anatomical alteration, delineates the so called PES syndrome. Read More

    Metabolic syndrome in Iranian adolescents with polycystic ovary syndrome.
    Int J Adolesc Med Health 2017 Aug 5. Epub 2017 Aug 5.
    Background Metabolic syndrome (MS) in adolescents is a risk factor for type 2 diabetes and cardiovascular diseases. Objective The present study aimed to determine the prevalence of MS in 14-18-year-old girls. Methods This analytical case-control study was conducted on 3200 high school students with polycystic ovarian syndrome (PCOS). Read More

    Pulmonary Artery Occlusion and Mediastinal Fibrosis in a Patient on Dopamine Agonist Treatment for Hyperprolactinemia.
    Front Pharmacol 2017 20;8:492. Epub 2017 Jul 20.
    Department of Cardiology, Aarhus University HospitalAarhus, Denmark.
    Unusual forms of pulmonary hypertension include pulmonary hypertension related to mediastinal fibrosis and the use of serotonergic drugs. Here, we describe a patient with diffuse mediastinal fibrosis and pulmonary hypertension while she was on dopamine agonist therapy. A young woman, who was treated with cabergoline and bromocriptine for hyperprolactinemia, presented with progressive dyspnea over several months. Read More

    Idiopathic Granulomatous Mastitis: A Clinical Puzzle in Breast Lump Cases.
    J Clin Diagn Res 2017 Jun 1;11(6):PD14-PD15. Epub 2017 Jun 1.
    Junior Resident, Department of General Surgery, SCB, Medical College, Cuttack, Odisha, India.
    Idiopathic granulomatous mastitis (IGM) is a rare benign disease, characterized by chronic inflammation and granulomatous disease process. A middle aged lady with breast lump for six months with equivocal mammographic and ultrasound results underwent lumpectomy and biopsy. Ruling out all other possible granulomatous diseases and malignancy, a diagnosis of IGM was made. Read More

    Effects of TNF-α on penile structure alteration in rats with hyperprolactinemia.
    PLoS One 2017 1;12(8):e0181952. Epub 2017 Aug 1.
    Department of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
    This study aimed to investigate the effects of anti-tumor necrosis factor (TNF)-α antibody (Ab) on alteration of penile structure in the hyperprolactinemia (hyperPRL) rat model. HyperPRL was induced in 8-week-old male Sprague-Dawley rats by allografting anterior pituitary (AP) glands under the renal capsule (+AP rats). Rats implanted with cerebral cortex (CX) were used as sham control (+CX rats). Read More

    Hyperprolactinaemia in first episode psychosis - A longitudinal assessment.
    Schizophr Res 2017 Jul 27. Epub 2017 Jul 27.
    Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; National Psychosis Service, South London and Maudsley NHS Foundation Trust, London, UK. Electronic address:
    Little is known about hyperprolactinaemia (HPL) in first episode psychosis (FEP) patients. We investigated longitudinal changes in serum prolactin in FEP, and the relationship between HPL, and antipsychotic medication and stress. Serum prolactin was recorded in FEP patients at recruitment and again, 3 and 12months later. Read More

    Antipsychotic-induced hyperprolactinemia in Tourette syndrome.
    Ther Adv Psychopharmacol 2017 Jul 21;7(6-7):201-205. Epub 2017 Apr 21.
    Diabeter, Center for Pediatric and Adolescent Diabetes Care and Research, Rotterdam, The Netherlands.
    For many years, Tourette syndrome (TS) was considered to be a rare disorder, but tics and TS are now recognized as fairly common childhood-onset conditions. Children and adolescents with TS are frequently treated with antipsychotics, either as monotherapy or in combination with psychostimulants, melatonin and selective serotonin reuptake inhibitors (SSRIs). Antipsychotics are most often used in schizophrenia and related psychotic disorders, and in these conditions hyperprolactinemia is one of the most common adverse effects associated with antipsychotics, occurring in 40-50% of patients. Read More

    Autoimmune hypothyroidism is three times more frequent in female prolactinoma patients compared to healthy women: data from a cross-sectional case-control study.
    Endocrine 2017 Jul 19. Epub 2017 Jul 19.
    University Hospital of Endocrinology, Sofia, Bulgaria.
    Background: The potent immunomodulatory action of prolactin has been demonstrated in many experimental in vitro studies. In accordance with these data, our retrospective analyses revealed higher prevalence of autoimmune thyroid diseases in prolactinoma patients compared to general population.

    Purpose: A cross-sectional case-control study was carried out in a single tertiary referral centre. Read More

    A study of neuroendocrine dysfunction in patients of tuberculous meningitis.
    J Neurol Sci 2017 Aug 13;379:198-206. Epub 2017 Jun 13.
    Department of Endocrinology, King George's Medical University, Lucknow, India.
    Background: Endocrine dysfunction is known to occur in various infectious diseases of the brain. The neuroendocrine dysfunction is not well studied in patients of Tuberculous meningitis (TBM). In this study, we aimed at knowing pattern of endocrine dysfunction in newly diagnosed patients of tuberculous meningitis, structural changes occurring in hypothalamic-pituitary region, assessing its predictors and correlative factors related to outcome. Read More

    Physical Health Outcomes in Preschoolers with Prior Authorization for Antipsychotics.
    J Child Adolesc Psychopharmacol 2017 Jul 14. Epub 2017 Jul 14.
    1 Department of Pharmaceutical Outcomes and Policy, University of Florida College of Pharmacy , Gainesville, Florida.
    Objective: To examine incidence of adverse health outcomes and associated factors among preschoolers (under age 6) who received antipsychotic treatment through the Florida Medicaid Prior Authorization (PA) program.

    Methods: Using Florida's PA registry linked to the state's Medicaid claims data, we ascertained incident outcomes during PA-approved antipsychotic use between April 2008 and September 2015 (7.5 years). Read More

    Pregnancy and Tumor Outcomes in Women with Prolactinoma.
    Exp Clin Endocrinol Diabetes 2017 Jul 13. Epub 2017 Jul 13.
    Faculty of Medicine, University of Porto. Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
    Context Management of prolactinomas during pregnancy has always been a challenge. There is a concern about the risk of tumor growth, as well as the effects of the treatment on the developing fetus. Another issue that has been less studied is the outcome of women with prolactinoma after pregnancy and lactation. Read More

    Insight into the Endocrine System and the Immune System: A Review of the Inflammatory Role of Prolactin in Rheumatoid Arthritis and Psoriatic Arthritis.
    Front Immunol 2017 23;8:720. Epub 2017 Jun 23.
    Laboratory of Translational Immunology, Department of Rheumatology and Clinical Immunology, University Medical Center, Utrecht, Netherlands.
    Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects females three times more frequently than males. A potential role for hormones, such as prolactin (PRL), may in part explain this phenomenon. The risk of developing RA is increased in women who are lactating after the first pregnancy, which might be related to breastfeeding and the release of PRL. Read More

    [Pituitary hyperplasia due to primary hypothyroidism].
    Rev Med Interne 2017 Jul 6. Epub 2017 Jul 6.
    Service d'endocrinologie et diabétologie, hôpital Hedi-Chaker, avenue Majida-Boulila, 3029 Sfax, Tunisie.
    Introduction: Pituitary hyperplasia due to primary hypothyroidism is rare and underdiagnosed.

    Case Report: We report an 18-year-old patient referred for a pituitary mass revealing primary hypothyroidism. Biological parameters confirmed severe primary hypothyroidism and hyperprolactinemia. Read More

    A novel role for dopamine signaling in the pathogenesis of bone loss from the atypical antipsychotic drug risperidone in female mice.
    Bone 2017 Oct 6;103:168-176. Epub 2017 Jul 6.
    Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, ME, USA. Electronic address:
    Atypical antipsychotic (AA) drugs, including risperidone (RIS), are used to treat schizophrenia, bipolar disorder, and autism, and are prescribed off-label for other mental health issues. AA drugs are associated with severe metabolic side effects of obesity and type 2 diabetes. Cross-sectional and longitudinal data also show that risperidone causes bone loss and increases fracture risk in both men and women. Read More

    Rejuvenating Effect of Long-Term Insulin-Like Growth Factor-I Gene Therapy in the Hypothalamus of Aged Rats with Dopaminergic Dysfunction.
    Rejuvenation Res 2017 Sep 6. Epub 2017 Sep 6.
    1 INIBIOLP-Pathology B, UNLP , La Plata, Argentina .
    The aging female rat constitutes an interesting model of spontaneous and progressive age-related dopaminergic dysfunction as it allows assessing new therapeutic strategies for Parkinson's disease. Insulin-like growth factor I (IGF-I) is emerging as a powerful neuroprotective molecule, strongly induced in the central nervous system after different insults. We constructed a helper-dependent recombinant adenoviral vector (HDRAd-IGFI) harboring the gene for rat IGF-I. Read More

    Safety concerns associated with second-generation antipsychotic long-acting injection treatment. A systematic update.
    Horm Mol Biol Clin Investig 2017 Jun 23. Epub 2017 Jun 23.
    Background It has been recently suggested that second-generation antipsychotic long-acting injection (SGA-LAIs) are underutilized in clinical practice, despite that their costs significantly impact on national health system budgets. Hence, an updated analysis of safety data shown by SGA-LAIs may contribute to clarify their role in clinical practice. Materials and methods English-language, peer-reviewed articles reporting updated, primary findings on the SGA-LAI safety were identified (updated through an electronic search of five databases - PubMed, EMBASE, PsycInfo, DARE and the Cochrane Library). Read More

    Menstrual Cycle Abnormalities in Patients with Prolactinoma and Drug-induced Hyperprolactinemia.
    Indian J Endocrinol Metab 2017 Jul-Aug;21(4):545-550
    Department of Endocrinology, PGIMER, Dr. RML Hospital, New Delhi, India.
    Background And Objective: Hyperprolactinemia affects the reproductive endocrine axis; however, the degree of dysfunction may vary depending on etiology. The aim of the present study was to analyze menstrual cyclicity in patients with prolactinoma and drug-induced hyperprolactinemia (DIH).

    Methodology: Patients with prolactinoma and DIH were retrospectively analyzed for menstrual cyclicity at presentation and response to therapy. Read More

    [The influence of the comprehensive spa and health resort-based treatment on the system of hormonal regulation in the women presenting with gynecological pathology depending on the plasma prolactin level].
    Vopr Kurortol Fizioter Lech Fiz Kult 2017 ;94(2):47-52
    'Poltava-Krym' Clinical Health Resort, Morskaya str., 8, Saki, Republic of Crimea, Russia, 296500.
    Aim: The objective of the present study was to evaluate the influence of the comprehensive spa and health resort-based treatment on the system of hormonal regulation in the women presenting with bacterial vaginosis and concomitant chronic inflammatory diseases of the pelvic organs depending on the plasma prolactin level.

    Material And Methods: We investigated the indicators of hormonal regulation in 186 women suffering from bacterial vaginosis and concomitant chronic inflammatory diseases of the pelvic organs depending on the level of prolactin in blood plasma. The first group consisted of 128 women with the normal plasma prolactin levels whereas the second group was comprised of 58 women having hyperprolactinemia. Read More

    Evaluation of Potentially Prolactin-Related Adverse Events and Sexual Maturation in Adolescents with Schizophrenia Treated with Paliperidone Extended-Release (ER) for 2 Years: A Post Hoc Analysis of an Open-Label Multicenter Study.
    CNS Drugs 2017 Jun 28. Epub 2017 Jun 28.
    Neurosciences, Janssen Research & Development, LLC, 1125 Trenton-Harbourton Road, Titusville, NJ, 08560, USA.
    Background: Elevated prolactin levels (hyperprolactinemia) are a frequent adverse effect of antipsychotic medications, especially in young populations. Prolonged hyperprolactinemia may affect sexual functioning and the onset and progression of puberty.

    Objective: This study assessed potentially prolactin-related treatment-emergent adverse events (PPRL-TEAEs) and sexual maturation during long-term treatment of adolescents with paliperidone extended-release (ER). Read More

    POEMS syndrome: a rare cause of exudative ascites and chronic peripheral neuropathy.
    BMJ Case Rep 2017 Jun 20;2017. Epub 2017 Jun 20.
    Neurology Department, Rashid Hospital, Dubai, UAE.
    POEMS syndrome (Peripheral neuropathy, Organomegaly, Endocrinopathy, M protein, Skin changes) is a rare plasma cell disorder with multisystem involvementA 40-year-old man with a chronic history of unexplained peripheral neuropathy , presented with exudative ascites.He was found to have an incidental osteolytic lesion of the sacrum proven to be a plasmacytoma. Immunoelectrophoresis for monoclonal protein was negative. Read More

    Antipsychotic Use Among Adult Outpatients and Venous Thromboembolic Disease: A Retrospective Cohort Study.
    J Clin Psychopharmacol 2017 Aug;37(4):405-411
    From the *Pharmacology Department, School of Medicine, University of Buenos Aires; †Hospital de Emergencias Psiquiátricas Torcuato de Alvear; ‡Bipolar Disorder Program, Neuroscience Institute, Favaloro University; §Internal Medicine Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; and ∥Kaiser Permanente Center for Health Research, Portland, OR.
    Background: Treatment with antipsychotic (AP) agents is associated with incident thromboembolic events. However, the underpinnings of this association remain unknown. We sought to evaluate the effect of AP agents-categorized by their metabolic/sedative and hyperprolactinemia adverse effect profile-on the risk of venous thromboembolic disease during long-term follow-up. Read More

    Cabergoline-induced Mania in a Patient of Pituitary Microadenoma.
    Indian J Psychol Med 2017 May-Jun;39(3):350-351
    Department of Psychiatry, Mental Health Institute, S.C.B. Medical College, Cuttack, Odisha, India.
    Cabergoline, a dopamine agonist agent, is commonly used in the treatment of hyperprolactinemia, Parkinson's disease, restless leg syndrome, and antipsychotic-induced prolactin elevation. It is generally well tolerated as compared to other dopamine agonist agents due to its more selective D2 receptor agonistic effect. We present a case of a 25-year-old female who developed manic episode, following the use of cabergoline for treatment of pituitary microadenoma. Read More

    Role of Na+/K(+)-ATPase in Natriuretic Effect of Prolactin in a Model of Cholestasis of Pregnancy.
    Biochemistry (Mosc) 2017 May;82(5):632-641
    Lomonosov Moscow State University, Faculty of Biology, Moscow, 119991, Russia.
    Participation of Na+/K+-ATPase in the natriuretic effect of prolactin in a cholestasis of pregnancy model was investigated. The Na+/K+-ATPase activity in rat kidney medulla, where active sodium reabsorption occurs, decreased in the model of cholestasis of pregnancy and other hyperprolactinemia types compared with intact animals. This effect was not connected with the protein level of α1- and β-subunits of Na+/K+-ATPase measured by Western blotting in the kidney medulla. Read More

    Xanthomatous Hypophysitis Presenting with Diabetes Insipidus Completely Cured Through Transsphenoidal Surgery: Case Report and Literature Review.
    World Neurosurg 2017 Aug 3;104:1051.e7-1051.e13. Epub 2017 Jun 3.
    Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, People's Republic of China. Electronic address:
    Background: Xanthomatous hypophysitis (XH) is extremely rare. Only 27 cases have been reported in the literature. No XH patient presenting with diabetes insipidus (DI) has been completely cured through surgery. Read More

    Topiramate add-on treatment associated with normalization of prolactin levels in a patient with schizophrenia.
    Neuropsychiatr Dis Treat 2017 24;13:1395-1397. Epub 2017 May 24.
    Department of Psychiatry, The First Affiliated Hospital of China Medical University.
    Topiramate has been used increasingly in the management of psychiatric conditions. Clinical trials demonstrated that topiramate augmentation was effective in controlling negative symptoms in schizophrenia. This case report presents a case of a 38-year-old man with schizophrenia who achieved full negative symptom remission upon the adjunctive use of topiramate. Read More

    Dopaminergic Regulation of Innate Immunity: a Review.
    J Neuroimmune Pharmacol 2017 Jun 3. Epub 2017 Jun 3.
    Center of Research in Medical Pharmacology, University of Insubria, Via Ottorino Rossi n. 9, 21100, Varese, VA, Italy.
    Dopamine (DA) is a neurotransmitter in the central nervous system as well as in peripheral tissues. Emerging evidence however points to DA also as a key transmitter between the nervous system and the immune system as well as a mediator produced and released by immune cells themselves. Dopaminergic pathways have received so far extensive attention in the adaptive branch of the immune system, where they play a role in health and disease such as multiple sclerosis, rheumatoid arthritis, cancer, and Parkinson's disease. Read More

    Comparative efficacy and safety of antipsychotics in the treatment of schizophrenia: a network meta-analysis in a Japanese population.
    Neuropsychiatr Dis Treat 2017 11;13:1281-1302. Epub 2017 May 11.
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
    Background: The relative efficacy and tolerability of antipsychotics for schizophrenia are considerably well studied. This study aimed to examine whether previous findings could be replicated in a genetically distinct and homogenous group (ie, Japanese patients with schizophrenia) and whether previous findings could be extended to a broader range of antipsychotics with previously unclear relative efficacy and tolerability.

    Methods: Bayesian network meta-analysis was performed in which randomized trials comparing any of the following interventions were included: second-generation antipsychotics, haloperidol, or placebo. Read More

    Hyperprolactinaemia - a problem in patients from the reproductive period to the menopause.
    Prz Menopauzalny 2017 Mar 26;16(1):1-7. Epub 2017 Apr 26.
    2 Department of Gynecology, Lublin Medical University, Lublin, Poland.
    Hyperprolactinaemia especially affects women in reproductive age (90/100,000) but also often is diagnosed in menopause age and leads to disturbances in functioning of LH-RH neurons and, as a consequence, to a decrease of FSH and LH, which causes inhibition of oestradiol production. Prolactin is a peptide hormone, phylogenetically one of the oldest, stimulating cells of various organs, which is produced and secreted mainly by lactotrophic acidophilic cells of the anterior lobe of the pituitary. It influences the increase in the mass of the mammary glands, and stimulation and maintenance of lactation after delivery. Read More

    Effectiveness of paliperidone depot injection in seriously violent men with comorbid schizophrenia and dissocial personality disorder in a UK high-security hospital.
    Ther Adv Psychopharmacol 2017 May 27;7(5):169-179. Epub 2017 Mar 27.
    Consultant Forensic Psychiatrist, Top End Mental Health Service, PO Box 140, Parap, NT 0804, Australia.
    Background: High-security hospital patients are often complex in presentation and are characterized by treatment resistance, medication nonadherence and history of violence. Paliperidone is licensed both as an oral and depot antipsychotic medication in the treatment of schizophrenia. Clinical trials have shown that paliperidone depot is well tolerated with similar efficacy to risperidone depot but with additional practical advantages. Read More

    Serum Prolactin Levels in Patients with Major Depressive Disorder Receiving Selective Serotonin-Reuptake Inhibitor Monotherapy for 3 Months: A Prospective Study.
    Psychiatry Investig 2017 May 16;14(3):368-371. Epub 2017 May 16.
    Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.
    Objective: It is unclear whether selective serotonin-reuptake inhibitors (SSRIs) can significantly increase the prolactin level. The purpose of this study was to identify the relationship between the prolactin level and the administration of SSRIs such as escitalopram and sertraline. An additional purpose was to determine whether the elevation of prolactin differs between escitalopram and sertraline treatment. Read More

    Occurrence of hyperprolactinemia in children with subclinical hypothyroidism.
    J Clin Res Pediatr Endocrinol 2017 May 22. Epub 2017 May 22.
    Background: Prevalence of hyperprolactinemia in children with subclinical hypothyroidism (ScH) is not known. This study aimed to determine the occurrence and predictors of hyperprolactinemia in children with euthyroidism, ScH and overt primary hypothyroidism (OPH).

    Methods: Consecutive children <18 years age, diagnosed to have normal thyroid function, ScH or OPH underwent serum prolactin estimation. Read More

    Bipolar patients treated with long-acting injectable risperidone in Taiwan: A 1-year mirror-image study using a national claims database.
    J Affect Disord 2017 Aug 3;218:327-334. Epub 2017 May 3.
    School of Health Care Administration, Taipei Medical University, Taipei, Taiwan. Electronic address:
    Objective: Bipolar disorder (BD) is burdensome for patients and healthcare systems. This study evaluated changes in concomitant medication patterns, healthcare utilization, and costs after the initiation of risperidone long-acting injection (RLAI) treatment among BD patients.

    Method: 287 BD patients receiving regular RLAI treatment for 1 year were identified from the Taiwan National Health Insurance Research database during 2007-2012. Read More

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