6,872 results match your criteria Hyperprolactinemia


Cabergoline Withdrawal Before and After Menopause: Outcomes in Microprolactinomas.

Horm Cancer 2019 Apr 18. Epub 2019 Apr 18.

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Natural course of prolactinomas after menopause is not fully elucidated. The aim of this study was to compare recurrence rate after cabergoline withdrawal in premenopausal vs. postmenopausal women with microprolactinoma. Read More

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http://dx.doi.org/10.1007/s12672-019-00363-4DOI Listing

Bromocriptine and cabergoline induce cell death in prolactinoma cells via the ERK/EGR1 and AKT/mTOR pathway respectively.

Cell Death Dis 2019 Apr 18;10(5):335. Epub 2019 Apr 18.

Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, 210002, Nanjing, China.

The treatment of hyperprolactinemia is based on the use of dopamine agonists, mainly bromocriptine (BRC) and cabergoline (CAB). They reduce tumour size effectively and restore gonadal function. However, there is a difference in drug sensitivity between CAB and BRC in patients with prolactinoma, although the underlying mechanisms are still unknown. Read More

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http://dx.doi.org/10.1038/s41419-019-1526-0DOI Listing

Common Breast Problems.

Am Fam Physician 2019 Apr;99(8):505-514

Thomas Jefferson University, Philadelphia, PA, USA.

Palpable breast masses, mastalgia, and nipple discharge are commonly encountered symptoms in outpatient practice, causing significant patient anxiety and precipitating medical consultation. The initial workup includes a detailed clinical history and physical examination. Women presenting with a breast mass will require imaging and further assessment to exclude cancer. Read More

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April 2019
1 Read

[Bushen Huoxue herbal medicine for treating hyperprolactinemia in women: a Meta-analysis].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(6):1087-1093

Xiyuan Hosptial,China Academy of Chinese Medicine Sciences Beijing 100091,China.

The clinical efficacy of Bushen Huoxue traditional Chinese medicine( TCM) in the treatment of hyperprolactinemia were systematically evaluated,which provided evidence-based medical evidence for the treatment of hyperprolactinemia with Bushen Huoxue traditional Chinese medicine. The randomized controlled trials on the treatment of hyperprolactinemia with Bushen Huoxue traditional Chinese medicine were comprehensively searched by computer in PubMed,EMbase,Cochrane Library,CNKI,Wan Fang,VIP,CBM and Meta-analysis was performed. The search time is from the time of self-built database to September 28,2018. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20190125.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20190125.001DOI Listing
March 2019
2 Reads

Lurasidone-induced Parkinsonism and Hyperprolactinemia.

Indian J Psychol Med 2019 Mar-Apr;41(2):192-194

Department of Psychiatry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

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http://www.ijpm.info/text.asp?2019/41/2/192/246959
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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_274_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436398PMC
April 2019
1 Read

Prolactin concentration in various stages of endometriosis in infertile women.

JBRA Assist Reprod 2019 Apr 10. Epub 2019 Apr 10.

Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Science, Babol, Iran.

Objective: The relation between excessive prolactin and endometriosis-related infertility is debatable. Anovulation or defective luteal phase occurs frequently due to hyperprolactinemia in subfertile women. In this investigation, we evaluated the association between serum prolactin levels and the severity of endometriosis. Read More

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http://dx.doi.org/10.5935/1518-0557.20190020DOI Listing
April 2019
1 Read

A pharmacogenetic study of patients with schizophrenia from West Siberia gets insight into dopaminergic mechanisms of antipsychotic-induced hyperprolactinemia.

BMC Med Genet 2019 Apr 9;20(Suppl 1):47. Epub 2019 Apr 9.

Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Aleutskaya str., 4, Tomsk, Russian Federation, 634014.

Background: Hyperprolactinemia (HPRL) is a classical side effect of antipsychotic drugs primarily attributed to blockade of dopamine D2 receptors (DRD2s) on the membranes of lactotroph cells within the pituitary gland. Certain antipsychotic drugs, e.g. Read More

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http://dx.doi.org/10.1186/s12881-019-0773-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454588PMC
April 2019
2 Reads

Treatment of gynecomastia with prednisone: case report and literature review.

J Int Med Res 2019 Apr 8:300060519840896. Epub 2019 Apr 8.

contributed equally to this work.

This study aimed to report a unique case of primary adrenal insufficiency that was accompanied by painful gynecomastia, which was resolved by treatment with prednisone. Enlargement of the left breast with continuous weakness and generalized nausea in a male was discovered 3 months before admission. Magnetic resonance imaging of the brain was normal 1 month before presentation. Read More

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http://dx.doi.org/10.1177/0300060519840896DOI Listing
April 2019
5 Reads

Corynebacterium kroppenstedtii: a challenging culprit in breast abscesses and granulomatous mastitis.

Curr Opin Obstet Gynecol 2019 Apr 2. Epub 2019 Apr 2.

Department of Pharmacy, Montefiore Medical Center, Wakefield Division.

Purpose Of Review: Corynebacterium kroppenstedtii is a difficult pathogen associated with granulomatous mastitis and recurrent breast abscesses. Despite over a dozen studies, there is no guidance on surgical interventions, steroid use, or dosing or duration of antibiotic treatment.

Recent Findings: Initially seen in predominantly Maori and Pacific Islander multiparous, postlactating women, C. Read More

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http://dx.doi.org/10.1097/GCO.0000000000000541DOI Listing
April 2019
3 Reads

Letter to the Editor: [A Meta-Analysis of the Prevalence of Cardiac Valvulopathy in Patients with Hyperprolactinemia Treated with Cabergoline].

J Clin Endocrinol Metab 2019 Apr 1. Epub 2019 Apr 1.

Department of Diabetes and Endocrinology, Princess Alexandra Hospital Brisbane, and Faculty of Medicine, the University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1210/jc.2019-00577DOI Listing
April 2019
2 Reads

No impact of treated hyperprolactinemia on cumulative live birth rate and perinatal outcomes in in vitro fertilization-embryo transfer.

J Obstet Gynaecol Res 2019 Apr 1. Epub 2019 Apr 1.

Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Aim: To investigate whether treated hyperprolactinemia has an impact on pregnancy outcomes in in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET).

Methods: A retrospective cohort study was conducted on 535 women who underwent IVF/ICSI-ET between January 2012 and December 2016, of which 123 had treated hyperprolactinemia (case group), 369 were matched controls. Besides, 43 remained hyperprolactinemic after treatment consisted of abnormal group. Read More

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http://dx.doi.org/10.1111/jog.13957DOI Listing
April 2019
2 Reads

ISMP Adverse Drug Reactions: Longitudinal Thumbnail Fissures Due to Erlotinib Priapism Associated With the Use of ExtenZe Blindness From a Nevirapine-Based HAART Regimen Hyperprolactinemia and Galactorrhea Due to Aripiprazole Trypophobia Associated With Gabapentin Coadministered Linezolid and Methadone Cause Serotonin Syndrome.

Hosp Pharm 2019 Apr 23;54(2):88-92. Epub 2019 Jan 23.

Temple University School of Pharmacy, Philadelphia, PA, USA.

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. E-mail Dr. Read More

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http://dx.doi.org/10.1177/0018578718824449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431722PMC
April 2019
3 Reads

Acute suppression of LH secretion by prolactin in female mice is mediated by kisspeptin neurons in the arcuate nucleus.

Endocrinology 2019 Mar 22. Epub 2019 Mar 22.

Centre for Neuroendocrinology and Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.

Hyperprolactinemia causes infertility, but the specific mechanism is unknown. It is clear that elevated prolactin levels suppress pulsatile release of gonadotrophin-releasing hormone (GnRH) from the hypothalamus, with a consequent reduction in pulsatile luteinizing hormone (LH) secretion from the pituitary. Only a few GnRH neurons express prolactin receptors (Prlr), however, and thus prolactin must act indirectly in the underlying neural circuitry. Read More

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http://dx.doi.org/10.1210/en.2019-00038DOI Listing
March 2019
1 Read

Prolactin - a pleiotropic factor in health and disease.

Nat Rev Endocrinol 2019 Mar 21. Epub 2019 Mar 21.

Inserm U1185, Faculté de Médecine Paris Sud, Université Paris-Saclay, Le Kremlin Bicêtre, France.

The principal role of prolactin in mammals is the regulation of lactation. Prolactin is a hormone that is mainly synthesized and secreted by lactotroph cells in the anterior pituitary gland. Prolactin signalling occurs via a unique transmembrane prolactin receptor (PRL-R). Read More

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http://dx.doi.org/10.1038/s41574-019-0194-6DOI Listing
March 2019
1 Read

The Intriguing Case of a Double Pituitary Adenoma.

World Neurosurg 2019 Mar 18. Epub 2019 Mar 18.

Department of Medicine Division of Endocrinology, Emory University School of Medicine, Atlanta, GA; Department of Neurological Surgery, Emory University School of Medicine, Atlanta, GA. Electronic address:

Background: When distinct pituitary hypersecretory manifestations coexist, the differential diagnosis includes plurihormonal or double pituitary adenomas. We describe a rare case of hypercortisolemia and hyperprolactinemia caused by two non-contiguous adenomas that required two surgeries.

Case Presentation: A 37-year-old woman presented with 6-month of weight gain, amenorrhea, joint pain, leg swelling and skin changes. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.242DOI Listing
March 2019
3 Reads

Pitfalls in the Diagnostic Evaluation of Hyperprolactinemia.

Neuroendocrinology 2019 Mar 20. Epub 2019 Mar 20.


An appropriate diagnostic evaluation is essential for the most appropriate treatment to be performed. Currently, macroprolactinemia is the third most frequent cause of non-physiological hyperprolactinemia after drugs and prolactinomas. Up to 40% of macroprolactinemic patients may present with hypogonadism symptoms, infertility and/or galactorrhea. Read More

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http://dx.doi.org/10.1159/000499694DOI Listing
March 2019
2 Reads

Clinical manifestations, evaluation and management of hyperprolactinemia in adolescent and young girls: a brief review.

Acta Biomed 2019 Jan 23;90(1):149-157. Epub 2019 Jan 23.

Obstetrics and Gynecology Department of Venizeleio General Hospital, Heraklion, Crete, Greece.

Hyperprolactinemia (HPrl) is considered as a rare endocrinopathy in childhood. In children and adolescent girls, there are three major categories of HPrl causes; physiological, pathological and iatrogenic. Through hypogonadotropic hypogonadism, prolactin hypersecretion and production leads to the typical functional syndrome which is observed in female children and adolescents; delayed puberty, primary or secondary amenorrhea and/or galactorrhea. Read More

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http://www.mattioli1885journals.com/index.php/actabiomedica/
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http://dx.doi.org/10.23750/abm.v90i1.8142DOI Listing
January 2019
9 Reads

Hyperprolactinemia is associated with a high prevalence of serum autoantibodies, high levels of inflammatory cytokines and an abnormal distribution of peripheral B-cell subsets.

Endocrine 2019 Mar 18. Epub 2019 Mar 18.

Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.

Purpose: Hyperprolactinemia (HPRL) has been reported in many autoimmune diseases. However, the serum autoantibody profile and peripheral B-cell subset distribution in women with HPRL are largely unknown. The current study aimed to investigate the autoantibody prevalence and cytokine levels as well as to further explore the B-cell subset distribution in women with HPRL. Read More

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http://dx.doi.org/10.1007/s12020-019-01896-yDOI Listing
March 2019
1 Read
3.527 Impact Factor

Aripiprazole for the treatment of duloxetine-induced hyperprolactinemia: A case report.

J Affect Disord 2019 May 5;250:330-332. Epub 2019 Mar 5.

Jiangxi Mental Hospital of Nangchang University, 43 Shangfang Road, Nanchang, Jiangxi 330029, PR China. Electronic address:

Background: It is well known that aripiprazole co-treatment effectively reduces antipsychotic-induced hyperprolactinemia. However, the effectiveness of aripiprazole to treat high prolactin levels induced by antidepressant drugs with serotoninergic activity, such as duloxetine, remains unknown.

Case Presentation: An 18-year-old female diagnosed with major depressive disorder (MDD) was treated with 100 mg sertraline once daily. Read More

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http://dx.doi.org/10.1016/j.jad.2019.03.006DOI Listing
May 2019
1 Read

Hypothalamic-pituitary axis irradiation dose thresholds for the development of hypopituitarism in adult-onset gliomas.

Clin Endocrinol (Oxf) 2019 Mar 15. Epub 2019 Mar 15.

Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Background: Childhood brain tumour survivors who receive cranial radiotherapy undergo regular surveillance for the development ofhypothalamic-pituitary (HP) axis dysfunction. Much less attention has been given to radiation-induced hypopituitarism in patients with malignant brain tumours of adult onset.

Design: Retrospective cohort study. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13971
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http://dx.doi.org/10.1111/cen.13971DOI Listing
March 2019
8 Reads

Sertraline-Related Amenorrhea in an Adolescent.

Clin Neuropharmacol 2019 Mar 7. Epub 2019 Mar 7.

Department of Child and Adolescent Psychiatry, University of Health Sciences Medical Faculty, Istanbul, Turkey.

Amenorrhea is one of the clinical consequences of hyperprolactinemia. Although symptomatic hyperprolactinemia is among the well-described adverse reactions of antipsychotic agents, it may also be reported with the use of selective serotonin reuptake inhibitors. Hereby, we present a case of sertraline-related hyperprolactinemic amenorrhea in an adolescent. Read More

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http://dx.doi.org/10.1097/WNF.0000000000000336DOI Listing
March 2019
1 Read

mPRs represent a novel target for PRL inhibition in experimental prolactinomas.

Endocr Relat Cancer 2019 Mar 1. Epub 2019 Mar 1.

G Diaz-Torga, Lab Fisiopatologia Hormonal, IBYME- CONICET, CABA, BUenos Aires, C1428ADN, Argentina.

Membrane progesterone receptors are known to mediate rapid nongenomic progesterone effects in different cell types. Recent evidence revealed that mPRα is highly expressed in the rat pituitary, being primarily localized in lactotrophs, acting as an intermediary of P4-inhibitory actions on prolactin secretion. The role of mPRs in prolactinoma development remains unclear. Read More

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http://dx.doi.org/10.1530/ERC-18-0409DOI Listing
March 2019
1 Read

Acute effects of somatomammotropin hormones on neuronal components of the hypothalamic-pituitary-gonadal axis.

Brain Res 2019 Mar 6. Epub 2019 Mar 6.

Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil. Electronic address:

Growth hormone (GH) and prolactin (PRL) are known as pleiotropic hormones. Accordingly, the distribution of their receptors comprises several organs and tissues, including the central nervous system. The appropriate secretion of both hormones is essential for sexual maturation and maintenance of reproductive functions, while defects in their secretion affect puberty onset and can cause infertility. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.003DOI Listing
March 2019
3 Reads

Dramatic Weight Loss Following Addition of Aripiprazole to Olanzapine in a Patient With Treatment-resistant Schizophrenia: A Case Report.

J Psychiatr Pract 2019 Mar;25(2):135-138

BOLAND and CHHABRA: West London Mental Health NHS Trust, London, UK.

Case Summary: A 26-year-old man with a history of longstanding treatment-resistant schizophrenia gained a substantial amount of weight while being treated with high-dose combination antipsychotic therapy with olanzapine and amisulpride. The patient was switched to combination therapy with olanzapine and aripiprazole to reverse a drug-induced hyperprolactinemia. The patient subsequently lost over 37 lb in weight over a period of 4 months despite no measurable changes in his dietary caloric intake or in his level of physical activity and without any identifiable medical cause on physical investigation. Read More

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http://dx.doi.org/10.1097/PRA.0000000000000372DOI Listing
March 2019
2 Reads

Hyperprolactinemia in psychotic patients treated in monotherapy with long-acting injectable antipsychotics.

Int J Psychiatry Clin Pract 2019 Mar 8:1-5. Epub 2019 Mar 8.

a Department of Psychiatry , Hospital General Universitario de Elche , Alicante , Spain.

Objectives: Hyperprolactinemia (HPRL), defined as plasma prolactin (PRL) >25 ng/ml, is a frequent adverse effect of the treatment with some antipsychotics. The objectives of this study were to determine the prevalence of HPRL among schizophrenic patients treated with long-acting injectable (LAI) antipsychotic drugs at our hospital, and to estimate gender effects in PRL levels in these patients.

Methods: This cross-sectional, retrospective, study analyzed 165 psychotic patients treatment with LAI antipsychotics in monotherapy from February to May of 2017 at the Psychiatry Specialized Care Units of the Elche General Hospital (Spain). Read More

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http://dx.doi.org/10.1080/13651501.2019.1576905DOI Listing
March 2019
2 Reads
1.313 Impact Factor

Hyperprolactinemic African elephant (Loxodonta africana) females exhibit elevated dopamine, oxytocin and serotonin concentrations compared to normal cycling and non-cycling, low prolactin elephants.

Biol Reprod 2019 Mar 8. Epub 2019 Mar 8.

Center for Species Survival, Smithsonian Conservation Biology Institute, Front Royal, VA.

Many zoo elephants do not cycle normally, and for African elephants, it often is associated with hyperprolactinemia. Dopamine agonists successfully treat hyperprolactinemia-induced ovarian dysfunction in women, but not elephants. The objective of this study was to determine how longitudinal dopamine, serotonin and oxytocin patterns in African elephants are related to ovarian cycle function. Read More

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http://dx.doi.org/10.1093/biolre/ioz036DOI Listing
March 2019
1 Read

[Hypophysitis and retroperitoneal fibrosis associated with autoimmune polyglandular syndrome and IgG4-related disease. Report of one case].

Rev Med Chil 2018 Dec;146(12):1486-1492

Servicio de Medicina, Hospital Naval A. Nef., Viña del Mar, Chile.

We report a 23 year old woman presenting with a nephrotic syndrome due to minimal change disease, central diabetes insipidus, primary hypothyroidism, vitiligo and universal alopecia. Eleven years later, she presented secondary amenorrhea due to hypogonadotropic hypogonadism, with mild hyperprolactinemia and central adrenal insufficiency. A magnetic resonance imaging of the sella turcica showed a pituitary mass with suprasellar extension that was resected using a transsphenoidal approach. Read More

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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.4067/s0034-98872018001201486DOI Listing
December 2018
9 Reads
0.373 Impact Factor

CARDIOMETABOLIC RISK FACTORS IN YOUNG WOMEN WITH MACROPROLACTINEMIA.

Endokrynol Pol 2019 Mar 7. Epub 2019 Mar 7.

Medical University of Silesia - Depratment of Internal Medicine and Clinical Pharmacology, Medykow 18, 40-752 Katowice, Poland.

Introduction: The predominance of high molecular weight forms of prolactin in plasma is referred to as macroprolactinemia. Unlike monomeric hyperprolactinemia, no previous study has investigated cardiometabolic risk factors in subjects with elevated macroprolactin content.

Material And Methods: We studied two age-, weight-, and blood pressure-matched groups of premenopausal women: 11 women with macroprolactinemia and 11 women with prolactin levels within the reference range. Read More

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http://dx.doi.org/10.5603/EP.a2019.0013DOI Listing
March 2019
7 Reads

Echocardiography and monitoring patients receiving dopamine agonist therapy for hyperprolactinaemia: a joint position statement of the British Society of Echocardiography, the British Heart Valve Society and the Society for Endocrinology.

Echo Res Pract 2019 Mar;6(1):G1-G8

Department of Endocrinology, Bartholomew's Hospital, London, UK.

This is a joint position statement of the British Society of Echocardiography, the British Heart Valve Society and the Society for Endocrinology on the role of echocardiography in monitoring patients receiving dopamine agonist (DA) therapy for hyperprolactinaemia. (1) Evidence that DA pharmacotherapy causes abnormal valve morphology and dysfunction at doses used in the management of hyperprolactinaemia is extremely limited. Evidence of clinically significant valve pathology is absent, except for isolated case reports around which questions remain. Read More

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http://dx.doi.org/10.1530/ERP-18-0069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391931PMC
March 2019
1 Read

Echocardiography and monitoring patients receiving dopamine agonist therapy for hyperprolactinaemia: A joint position statement of the British Society of Echocardiography, the British Heart Valve Society and the Society for Endocrinology.

Clin Endocrinol (Oxf) 2019 May 28;90(5):662-669. Epub 2019 Feb 28.

Department of Endocrinology, Bartholomew's Hospital, London, UK.

This is a joint position statement of the British Society of Echocardiography, the British Heart Valve Society and the Society for Endocrinology on the role of echocardiography in monitoring patients receiving dopamine agonist (DA) therapy for hyperprolactinaemia. Evidence that DA pharmacotherapy causes abnormal valve morphology and dysfunction at doses used in the management of hyperprolactinaemia is extremely limited. Evidence of clinically significant valve pathology is absent, except for isolated case reports around which questions remain. Read More

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http://dx.doi.org/10.1111/cen.13940DOI Listing
May 2019
1 Read

Different cabergoline effect on metabolic and anthropometric parameters in female prolactinoma patients versus idiopathic hyperprolactinemia patients.

Endocr Metab Immune Disord Drug Targets 2019 Feb 18. Epub 2019 Feb 18.

Microbiology at specialized medical hospital, Mansoura University, Mansoura. Egypt.

Objective: We aimed in the current study to: 1) evaluate and compare metabolic and anthropometric profile in female patients with newly diagnosed prolactin secreting adenoma versus female idiopathic hyperprolactinemic patients 2) compare the effects of one year cabergoline therapy on the metabolic profile and anthropometric parameters (by using visceral adiposity index as index for evaluation of adipose tissue dysfunction) in female patients with prolactin secreting pituitary adenoma to female idiopathic hyperprolactinemic patients.

Patients And Methods: We enrolled 40 female patients with newly diagnosed prolactin-secreting pituitary adenoma (29 patients with micro adenoma and 11 patients with macro adenoma) and 40 female patients with idiopathic hyperprolactinemia, who were matched according to: age; weight; BMI; waist; and prolactin levels. The participants were enrolled in this study at the time of diagnosis before therapy. Read More

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http://dx.doi.org/10.2174/1871530319666190219103812DOI Listing
February 2019
1 Read

Increased androgen secretion in patients with prolactinomas: the impact of altered HPA function.

Pituitary 2019 Apr;22(2):170-178

Division of Clinical and Molecular Endocrinology, UH Cleveland Medical Center and Case Western University, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.

Background And Objectives: Earlier studies suggested that hyperprolactinemia was associated with elevated serum DHEA-S levels. The importance of DHEA-S measurements in the diagnosis of adrenal insufficiency prompted us to assess adrenal androgen levels in hyperprolactinemic subjects with normal or impaired function.

Methods: Prospective study including 122 medically treated and 26 surgically patients with prolactinomas. Read More

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http://dx.doi.org/10.1007/s11102-019-00948-wDOI Listing
April 2019
5 Reads

Sexual dysfunction and hyperprolactinemia in schizophrenia before and after six weeks of D receptor blockade - An exploratory study.

Psychiatry Res 2019 04 8;274:58-65. Epub 2019 Feb 8.

Center for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Denmark; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Clinical Medicine, Denmark.

Sexual side-effects along with antipsychotic treatment may be linked to hyperprolactinemia and dopamine D receptor blockade. High prevalence of sexual dysfunction in un-medicated patients challenges the notion of sexual dysfunction as merely a side-effect of antipsychotic medication. Sexual dysfunction was assessed in fifty-six initially antipsychotic-naïve patients with schizophrenia using the UKU (Udvalget for Kliniske Undersøgelser) questionnaire. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.017DOI Listing
April 2019
1 Read

Real-world effectiveness of antipsychotic monotherapy and polytherapy in 1543 patients with acute-phase schizophrenia.

Asian J Psychiatr 2019 Feb 8;40:82-87. Epub 2019 Feb 8.

Department of Psychiatry, Numazu Chuo Hospital, Numazu, Japan.

Purpose: The effectiveness of antipsychotic treatments in the acute phase of schizophrenia in actual clinical practice remains somewhat unclear. Therefore, the purpose of the present naturalistic, multi-center study conducted from 1 year starting in September 2017 was to examine the response rate to an initial or second antipsychotic in newly admitted patients with acute-phase schizophrenia, as well as the response rate and quality of augmentation with two antipsychotics in patients who failed to respond to both the initial and second antipsychotics.

Results: In total, there were 660 (42. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.02.005DOI Listing
February 2019
2 Reads

Impact of the CYP2D6 phenotype on hyperprolactinemia development as an adverse event of treatment with atypical antipsychotic agents in pediatric patients.

Ir J Med Sci 2019 Feb 15. Epub 2019 Feb 15.

Discipline of Medical Genetics, Department of Microscopic Morphology, Victor Babeş University of Medicine and Pharmacy Timișoara, Timișoara, Romania.

Background: Treatment with atypical antipsychotics is today the election therapy for different types of psychosis, but there is a high incidence of endocrine and metabolic disturbances. One of the major enzymes involved in the metabolism of antipsychotics is CYP2D6. Depending on the existing CYP2D6 alleles, the metabolic capacity of the enzyme may vary from very low to very high, so that patients can be grouped into four phenotypic groups: slow, intermediate, extensive (normal), and fast metabolizers. Read More

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http://dx.doi.org/10.1007/s11845-019-01985-xDOI Listing
February 2019
1 Read

Prolactin and alteration of fertility.

Ceska Gynekol Winter 2018;83(3):232-235

Aim: Physiology and pathology of prolactin production, clinical consequences.

Design: Review.

Setting: Reprogenesis International, Brno. Read More

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February 2019
9 Reads

Retrospective Analysis of the Effectiveness and Tolerability of Long-Acting Paliperidone Palmitate Antipsychotic in Adolescent First-Episode Schizophrenia Patients.

J Child Adolesc Psychopharmacol 2019 Apr 13;29(3):197-204. Epub 2019 Feb 13.

1 Department of Child and Adolescent Psychiatry, Clinical Hospital Centre Rijeka, Rijeka, Croatia.

Objective: The aim of this study was to explore the effectiveness and tolerability of long-acting paliperidone palmitate antipsychotic in adolescent first-episode schizophrenia patients while comparing the results with the oral antipsychotic risperidone.

Methods: This study is a retrospective, noninterventional study to assess the effectiveness and tolerability of long-acting injectable antipsychotic paliperidone palmitate in first-episode adolescent patients during the first 12 months of treatment compared with the oral antipsychotic risperidone. The data include general sociodemographic characteristics, number of hospitalizations, side effects, and the following clinical scales: Positive and Negative Syndrome Scale (PANSS), Personal and Social Performance Scale (PSP), Clinical Global Impression Improvement and Severity (CGI-I and CGI-S), and Treatment Satisfaction Questionnaire for Medication (TSQM). Read More

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http://dx.doi.org/10.1089/cap.2018.0044DOI Listing
April 2019
1 Read

Hypothalamic-pituitary-gonadal axis dysfunction: An innate pathophysiology of schizophrenia?

Authors:
X Du R A Hill

Gen Comp Endocrinol 2019 05 10;275:38-43. Epub 2019 Feb 10.

Behavioural Neuroscience Laboratory, Department of Psychiatry, Monash University, Clayton, Victoria 3168, Australia.

The female hormone 17β-estradiol is postulated to be protective against schizophrenia onset and severity. Hypoestrogenism is a common phenomenon in women with schizophrenia that has serious effects that adds to the burden of an already very onerous disease. The cause of hypoestrogenism is largely attributed to antipsychotic-induced hyperprolactinemia. Read More

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http://dx.doi.org/10.1016/j.ygcen.2019.02.009DOI Listing
May 2019
2 Reads

Personalized strategies in reproductive medicine for patients with endocrine disorders.

Ter Arkh 2018 Apr;90(4):81-84

Endocrine Medical Research center, Ministry of Health of Russia, Moscow, Russia.

Endocrine Medical Research center (EMRC) of the Ministry of health of Russia is unique clinical center, that have no analogs in the world. All forms of endocrine disorders may be diagnosed and treated here by implication of innovative methods. Institute of reproductive medicine of EMRC was open on 2017, director of this institute - MD, PhD E. Read More

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http://dx.doi.org/10.26442/terarkh201890481-84DOI Listing
April 2018
2 Reads

Comparative evaluation of neuroendocrine dysfunction in children with craniopharyngiomas before and after mass effects are removed.

J Pediatr Endocrinol Metab 2019 Feb;32(2):127-133

Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, P.R. China, Phone: +13661307913.

Objective To compare the effects of mass effects in situ (MEIS) and after neurosurgery (ANS) on neuroendocrine function in children with craniopharyngioma. Methods We retrospectively investigated 185 cases of children with craniopharyngioma who underwent neurosurgical treatment at the Beijing Tiantan Hospital from 2011 to 2016. The neuroendocrine function of patients was compared before and after tumor removal. Read More

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http://dx.doi.org/10.1515/jpem-2018-0204DOI Listing
February 2019
6 Reads

Metabolic syndrome and endocrine status in HIV-infected transwomen.

AIDS 2019 Apr;33(5):855-865

Infectious and Tropical Diseases Department, Hôpitaux Universitaires Paris Nord Val de Seine (HUPNVS), AP-HP.

Background: HIV-infected transwomen face multiple specific issues. Economic and social marginalization, sex work, substance abuse, hormonal consumption and silicone injection may affect the course of HIV infection and lead to metabolic and endocrine complications.

Methods: A matched case-control study was performed between 2013 and 2015 in a University Hospital and compared metabolic syndrome (MetS), thyroid and adrenal functions in HIV-infected transwomen (i. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002152DOI Listing
April 2019
5 Reads

Impact of hyperprolactinemia in a patient with polyautoimmunity.

Clin Case Rep 2019 Jan 9;7(1):19-23. Epub 2018 Nov 9.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences Universidad del Rosario Bogota Colombia.

Hyperprolactinemia has been proposed as a triggering factor for autoimmune diseases. The increased levels of prolactin could induce an abnormal immune response. Herein, we present a patient with hyperprolactinemia who developed polyautoimmunity. Read More

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http://dx.doi.org/10.1002/ccr3.1900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333117PMC
January 2019
2 Reads

Prolactin, autoimmunity, and motherhood: when should women avoid breastfeeding?

Clin Rheumatol 2019 Jan 11. Epub 2019 Jan 11.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv University, 5265601, Tel Hashomer, Israel.

The sexual dimorphic prevalence of autoimmunity represents one of the most alluring observations among the mosaic of autoimmunity. Sex hormones are believed to be a mainstay of this asymmetry. The greater prevalence of autoimmunity among fertile women, disease onset/relapses during pregnancy, and postpartum are some of the points that support this theory. Read More

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http://link.springer.com/10.1007/s10067-018-04415-y
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http://dx.doi.org/10.1007/s10067-018-04415-yDOI Listing
January 2019
16 Reads

Effect of Kisspeptin on Serum Prolactin and Gonadotropins Levels in Balb-c Mice with Induced Chronic Stress.

J Coll Physicians Surg Pak 2019 Jan;29(1):41-44

Department of Physiology, Shifa College of Medicine, Islamabad, Pakistan.

Objective: To determine and compare effects of kisspeptin on serum prolactin, luteinizing hormone and follicle stimulating hormone levels in Balb-c mice with and without exposure to chronic restraint stress.

Study Design: An animal experimental study.

Place And Duration Of Study: Shifa College of Medicine / Shifa International Hospital Islamabad, in collaboration with National Institute of Health, Islamabad and Centre for Research in Experimental and Applied Medicine Laboratory, Army Medical College, Rawalpindi, from April 2014 to June 2015. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.01.41DOI Listing
January 2019
5 Reads

Clinical Presentation and Pathologic Characteristics of Pituitary Metastasis from Breast Carcinoma: Cases and a Systematic Review of the Literature.

World Neurosurg 2019 Jan 7. Epub 2019 Jan 7.

Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China. Electronic address:

Background: It is rare for breast carcinoma to metastasize to the pituitary gland; this finding indicates extensive metastasis of the primary tumor.

Case Description: Herein, we present a 57-year-old patient with pituitary gland metastasis from breast cancer that was treated with extensive radical mastectomy 16 years prior. The pituitary was the sole site of metastasis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183294
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http://dx.doi.org/10.1016/j.wneu.2018.12.126DOI Listing
January 2019
15 Reads

Antipsychotic use and fracture risk: An evaluation of incidence at a Veterans Affairs medical center.

Ment Health Clin 2019 Jan 4;9(1):6-11. Epub 2019 Jan 4.

Introduction: Recent meta-analyses have found a correlation between schizophrenia and increased fracture risk with one contributing factor potentially being antipsychotic-induced hyperprolactinemia, which may accelerate bone turnover. The objective of this study is to evaluate fracture rates in patients on long-term antipsychotic therapy to see if screening for osteoporosis should be included with routine monitoring.

Methods: Patients exposed to antipsychotics for ≥3 months during a 10-year study period were included in this retrospective analysis. Read More

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http://dx.doi.org/10.9740/mhc.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322822PMC
January 2019
3 Reads

Suprasellar chordoid glioma: a report of two cases.

Arch Endocrinol Metab 2018 ;62(6):648-654

Instituto de Investigaciones Neurológicas "Dr. Raúl Carrea", FLENI, Pathology, Buenos Aires, Argentina.

Chordoid glioma (CG) is considered a slow growing glial neoplasm. We report two new cases with endocrinological presentation, management and outcome. Case reports: 1) An 18 year-old female patient was admitted due to headaches, nausea and vomiting and visual abnormalities. Read More

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http://dx.doi.org/10.20945/2359-3997000000092DOI Listing
February 2019
5 Reads

Association of raised levels of IL-4 and anti-TPO with hyperprolactinemia.

Am J Reprod Immunol 2019 Mar 30;81(3):e13085. Epub 2019 Jan 30.

Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.

Background And Objective: The modulatory role of prolactin in autoimmune regulation is well established. Hyperprolactinemia is often associated with autoimmune disease like systemic lupus erythematosus and autoimmune thyroid diseases. The objective was to compare levels of direct and indirect autoimmune factors in different categories of hyperprolactinemia cases and predict the direction of association between hyperprolactinemia and autoimmune factors, if any. Read More

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http://dx.doi.org/10.1111/aji.13085DOI Listing
March 2019
4 Reads