7,234 results match your criteria Hyperprolactinemia

Analysis of prolactin and sexual side effects in patients with schizophrenia who switched from paliperidone palmitate to aripiprazole lauroxil.

Psychiatry Res 2021 May 27;302:114030. Epub 2021 May 27.

Alkermes, Inc., Waltham, MA, USA.

One strategy to address hyperprolactinemia and associated sexual side effects in patients receiving antipsychotics is switching to an antipsychotic not associated with prolactin elevation (eg, aripiprazole). This post hoc analysis assessed prolactin concentrations and sexual side effects in an open-label prospective study of switching long-acting injectable antipsychotics from paliperidone palmitate (PP) to aripiprazole lauroxil (AL). Serum prolactin was measured throughout the study. Read More

View Article and Full-Text PDF

Analytical platforms Vitros ECi 3600 and Cobas 6000: comparative analysis of prolactin measurement.

Klin Lab Diagn 2021 Jun;66(6):333-339

Endocrinology Research Centre.

Prolactin is a polypeptide hormone secreted by the lactotrophic cells of the anterior pituitary gland and has a wide range of biological effects in the human body. Accurate measurements of prolactin concentration are essential in obtaining biochemical data to support clinical decisions in the diagnosis, treatment and prevention of diseases of the pituitary gland, reproductive, immune and other body systems. The aim of our study is to carry out a comparative analysis of the serum prolactin measurement determined by the two analytical platforms Vitros ECi 3600 (Ortho-Clinical Diagnostics) and Cobas 6000 (Roche). Read More

View Article and Full-Text PDF

The patterns and occupational distribution of hormonal abnormalities among men investigated for infertility in some centers in the southwest, Nigeria.

J Clin Transl Res 2021 Apr 12;7(2):221-228. Epub 2021 Mar 12.

Department of Medical Laboratory Services, University Health Centre, Federal University of Technology Akure, Akure, Ondo State, Nigeria.

Background And Aim: Male factor infertility results from dysfunction at various levels of spermatogenesis, sex hormone abnormalities, and occupation or workplace exposure to toxins are involved. This study was designed to determine the frequency of occupational distribution of men who were evaluated for infertility, the patterns of hormonal abnormalities, and to associate hormonal abnormalities with occupational categories in some centers in Osun State, Nigeria.

Methods: Semen and 5 mL of whole blood were collected from the infertile men (n=319) who were referred to the laboratories for fertility investigation after physical and medical examination. Read More

View Article and Full-Text PDF

Morbid Obesity Due to Prolactinoma and Significant Weight Loss After Dopamine Agonist Treatment.

AACE Clin Case Rep 2021 May-Jun;7(3):204-206. Epub 2021 Mar 11.

Department of Endocrinology, Norman Regional Hospital, Oklahoma.

Objective: Morbid obesity may be related to a prolactinoma, although uncommon, and can lead to adverse effects like insulin resistance and metabolic syndrome. Recent research suggests that hyperprolactinemia causes an abnormal lipid profile, weight gain, and cardiovascular diseases. Moreover, high prolactin levels lead to decreased testosterone production by disrupting 17-b-estradiol synthesis. Read More

View Article and Full-Text PDF

Hyperprolactinemia, Clinical Considerations, and Infertility in Women on Antipsychotic Medications.

Psychopharmacol Bull 2021 Mar;51(2):131-148

Amber N. Edinoff, Nancy S. Silverblatt, Eden Girma, Louisiana State University Health Science Center Shreveport, Department of Psychiatry and Behavioral Medicine. Hayley E. Vervaeke, Cassidy C, Horton, Louisiana State University Shreveport School of Medicine. Alan D. Kaye, Treniece N. Eubanks, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA. Adam Kaye, Jessica S. Kaye, Andrew J. Garcia, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy Practice, Stockton, CA. Elisa E. Neuchat, Department of Biological Sciences, Florida International University, Miami, FL. Giustino Varrassi, Paolo Procacci Foundation, Via Tacito 7, Roma, Italy. Omar Viswanath, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA; University of Arizona College of Medicine-Phoenix, Phoenix, AZ; Valley Anesthesiology and Pain Consultants - Envision Physician Services, Phoenix, AZ. Ivan Urits, Louisiana State University Shreveport, Department of Anesthesiology, Shreveport, LA; Southcoast Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.

Infertility, the inability to establish a clinical pregnancy after 12 months of regular unprotected sexual intercourse, is caused by a wide variety of both male and female factors. Infertility is estimated to affect between 8-12% of couples trying to conceive globally. Female factor infertility can be subdivided into the following broad categories: ovulatory dysfunction, fallopian tubal disease, uterine causes, and oocyte quality. Read More

View Article and Full-Text PDF

Endocrine contribution to the sexual dysfunction in patients with advanced chronic kidney disease and the role of hyperprolactinemia.

Andrologia 2021 Jun 5:e14135. Epub 2021 Jun 5.

Department of Urology, Hamad General Hospital, Doha, Qatar.

In this study, we investigated the prevalence of sexual dysfunction among males with advanced chronic kidney disease and the effect of treating hyperprolactinemia among these patients. In this prospective study, patients were assessed with history, physical examination, hormonal assessment, and two questionnaires, IIEF and AIPE. Patients with hyperprolactinemia received treatment with cabergoline 0. Read More

View Article and Full-Text PDF

Risk of Nonalcoholic Fatty Liver Disease in Patients With Schizophrenia Treated With Antipsychotic Drugs: A Cross-sectional Study.

J Clin Psychopharmacol 2021 Jun 4. Epub 2021 Jun 4.

From the Departments of Psychiatry Internal Medicine, National Hospital Organization Shimofusa Psychiatric Medical Center, Chiba, Japan.

Background: Although the prevalence of metabolic syndrome in patients with schizophrenia is higher than the prevalence in the general population, little is known regarding nonalcoholic fatty liver disease (NAFLD) in patients with schizophrenia.

Procedures: We analyzed the medical records of patients with schizophrenia/schizoaffective disorder (N = 253) who received an abdominal echography.

Results: In total, 108 patients (42. Read More

View Article and Full-Text PDF

A case series of serious and unexpected adverse drug reactions under treatment with cariprazine.

Clin Case Rep 2021 May 4;9(5):e04084. Epub 2021 May 4.

Department of Psychiatry Social Psychiatry and Psychotherapy Hannover Medical School Hannover Germany.

Reporting of new or unexpected adverse drug reactions of medicines that are subject to additional monitoring ("black triangle" label), such as the antipsychotic drug cariprazine, is of paramount importance to improve pharmacotherapy safety. Read More

View Article and Full-Text PDF

Vitamin D status determines the impact of metformin on circulating prolactin levels in premenopausal women.

J Clin Pharm Ther 2021 Jun 2. Epub 2021 Jun 2.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

What Is Known And Objective: Metformin was found to normalize secretory function of overactive pituitary cells. Its effect on circulating thyrotropin levels was more pronounced in women receiving exogenous vitamin D. The aim of the current study was to investigate whether vitamin D status determines the impact of metformin on prolactin levels in premenopausal women with hyperprolactinaemia. Read More

View Article and Full-Text PDF

Treatment with assisted reproduction technologies in women with acute hepatic porphyria.

Acta Obstet Gynecol Scand 2021 Jun 1. Epub 2021 Jun 1.

Porphyria Centre Sweden, Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.

Introduction: The acute porphyrias are rare disorders of the heme biosynthetic pathway and present with acute neurovisceral symptoms that can be induced by hormonal changes and medications. Women are far more likely to present with clinical symptoms than men, particularly during parts of their lifetime with changes in the level of female sex hormones such as ovulation, menstruation and pregnancy. Treatment of ovulatory dysfunction and controlled ovarian hyperstimulation require the administration of hormones, which are considered porphyrinogenic. Read More

View Article and Full-Text PDF

Metabolic syndrome in the era of COVID-19 outbreak: impact of lockdown on cardiometabolic health.

J Endocrinol Invest 2021 May 26. Epub 2021 May 26.

Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università "Federico II" di Napoli, Naples, Italy.

Purpose: COVID-19 pandemics and cardiometabolic health are mutually interconnected. Chronic metabolic diseases are known risk factors for increased mortality after SARS-CoV-2 infection. In turn, COVID pandemics imposed sudden changes in lifestyle and social isolation with consequent potential cardiometabolic sequelae. Read More

View Article and Full-Text PDF

Hyperprolactinemia in a male pituitary androgen receptor knockout mouse is associated with female-like lactotroph development.

Andrology 2021 May 16. Epub 2021 May 16.

MRC Centre for Reproductive Health, The Queen's Medical Research Institute, Edinburgh, UK.

Background: Circulating prolactin concentration in rodents and humans is sexually dimorphic. Oestrogens are a well-characterised stimulator of prolactin release. Circulating prolactin fluctuates throughout the menstrual/oestrous cycle of females in response to oestrogen levels, but remains continually low in males. Read More

View Article and Full-Text PDF

Optimization of a Screening Method for Macroprolactinemia.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jun 25;1175:122723. Epub 2021 Apr 25.

Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, 310014, China. Electronic address:

Objective: To optimize a screening method for macroprolactinemia and improve the accuracy of free prolactin (freePRL) detection.

Method: Overall efficiency, calculated as the product of the immunoglobulin G (IgG) precipitation rate and the freePRL recovery rate were employed to determine the concentration of the precipitant polyethylene glycol (PEG). Then, an optimized screening method for macroprolactinemia was established. Read More

View Article and Full-Text PDF

Hyperprolactinemia using domperidone in prepubertal gilts: Effects on hormonal status, mammary development and mammary and pituitary gene expression.

C Farmer M F Palin

Domest Anim Endocrinol 2021 Jul 14;76:106630. Epub 2021 Apr 14.

Agriculture and Agri-Food Canada, Sherbrooke R & D Centre, Sherbrooke, QC, J1M 0C8, Canada.

Objectives of this experiment were to determine if the domperidone protocol previously used for gestating gilts can also lead to hyperprolactinemia in growing gilts, and to assess the effects of such a protocol on hormonal status, mammary development and gene expression in mammary and pituitary tissue of gilts at puberty. The impact on future lactation performance was also determined. At 75 ± 3 kg body weight (BW), gilts were divided between: 1) controls (CTL), receiving daily intramuscular (IM) injections of canola oil (1. Read More

View Article and Full-Text PDF

TPN672: A Novel Serotonin-Dopamine Activity Modulator for the Treatment of Schizophrenia.

J Pharmacol Exp Ther 2021 May 11. Epub 2021 May 11.

China Pharmaceutical University, China

TPN672,7-(2-(4-(benzothiophen-4-yl) piperazin-1-yl) ethyl) quinolin-2(1H)-one maleate, is a novel antipsychotic candidate with high affinity for serotonin and dopamine receptors, that is currently in clinical trial for the treatment of psychiatric disorders. In vitro binding study showed that TPN672 exhibited extremely high affinity for serotonin 1A receptor (5-HTR) (Ki = 0.23 nM) and 5-HTR (Ki = 2. Read More

View Article and Full-Text PDF

The transcriptomic profile of endometrial receptivity in recurrent miscarriage.

Eur J Obstet Gynecol Reprod Biol 2021 Jun 30;261:211-216. Epub 2021 Apr 30.

Tommy's National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.

Objective: To characterise the endometrial transcriptomic profiles of women who suffered recurrent miscarriage and to set the foundation for the development of an endometrial receptivity test that could predict the fate of subsequent pregnancies.

Study Design: This was a prospective multicentre cohort study performed at the Tommy's National Centre for Miscarriage Research in Birmingham, Saint Mary's Hospital in Manchester and Royal Devon & Exeter Hospital, United Kingdom. The study was conducted between December 2017 and December 2019. Read More

View Article and Full-Text PDF

Tumor volume improves preoperative differentiation of prolactinomas and nonfunctioning pituitary adenomas.

Endocrine 2021 May 8. Epub 2021 May 8.

Division of Endocrinology, Diabetes and Metabolism, NYU Langone Medical Center/ Bellevue Hospital Center, 550 1st Avenue, New York, NY, 10016, USA.

Purpose: Both prolactinomas and nonfunctioning adenomas (NFAs) can present with hyperprolactinemia. Distinguishing them is critical because prolactinomas are effectively managed with dopamine agonists, whereas compressive NFAs are treated surgically. Current guidelines rely only on serum prolactin (PRL) levels, which are neither sensitive nor specific enough. Read More

View Article and Full-Text PDF

Identification of an optimal prolactin threshold to determine prolactinoma size using receiver operating characteristic analysis.

Sci Rep 2021 May 7;11(1):9801. Epub 2021 May 7.

Department of Endocrinology ASO/EASO COM, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.

Prolactinomas represent the most common type of secretory pituitary neoplasms, with a therapeutic management that varies considerably based on tumour size and degree of hyperprolactinemia. The aim of the current study was to evaluate the relationship between serum prolactin (PRL) concentrations and prolactinoma size, and to determine a cut-off PRL value that could differentiate micro- from macro-prolactinomas. A retrospective cohort study of 114 patients diagnosed with prolactinomas between 2007 and 2017 was conducted. Read More

View Article and Full-Text PDF

Status epilepticus and diabetes ketoacidosis: uncommon clinical presentations of acromegaly.

Endocrinol Diabetes Metab Case Rep 2021 Apr 1;2021. Epub 2021 Apr 1.

Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.

Summary: Acromegaly is a rare disease caused by hypersecretion of the growth hormone (GH). Most cases are caused by either pituitary microadenoma or macroadenoma. The GH producing tumors present with clinical manifestations of acromegaly due to excessive GH secretion or symptoms resulting from mass effects of the enlarging tumor. Read More

View Article and Full-Text PDF

Guidance on the treatment of antipsychotic-induced hyperprolactinemia when switching the antipsychotic is not an option.

Am J Health Syst Pharm 2021 05;78(10):862-871

University of Missouri-Kansas City School of Pharmacy, Kansas City, MO, USA.

Purpose: This article aims to evaluate management options for antipsychotic-induced hyperprolactinemia and associated treatment considerations such as efficacy, tolerability, drug interactions, contraindications, and dosing regimens.

Summary: Hyperprolactinemia is a common adverse effect of antipsychotics. First-line management includes reducing the dose of the offending antipsychotic, discontinuing the antipsychotic, or switching to another antipsychotic associated with a lower risk of hyperprolactinemia. Read More

View Article and Full-Text PDF

Salivary gland tissues and derived primary and metastatic neoplasms: unusual pitfalls in the work-up of sellar lesions. A systematic review.

J Endocrinol Invest 2021 May 3. Epub 2021 May 3.

Neuromed Institute, IRCCS, Pozzilli, IS, Italy.

Purpose: Salivary gland (SG) tissue and derived neoplasms may occur in the sellar region. As the current literature is mostly limited to case reports, the puzzling case of an inflammatory SG removed by transsphenoidal surgery (TS) and mimicking a prolactinoma prompted us to perform the first systematic review of these unusual conditions.

Methods: A systematic literature search was conducted according to the PRISMA guidelines. Read More

View Article and Full-Text PDF

Distribution of Myeloid and Plasmacytoid Dendritic Cell Subpopulations in Peripheral Blood of Hyperprolactinemic Women.

Iran J Allergy Asthma Immunol 2021 Apr 17;20(2):198-204. Epub 2021 Apr 17.

Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Dendritic cells (DCs) play key roles in regulating the immune response using the specialized function of processing and presenting antigens. Prolactin (PRL), a hormone produced by the pituitary gland, participates in DC maturation and function. The present study was aimed to determine the frequencies of peripheral blood DC subpopulations of myeloid DC (MDC) and plasmacytoid DC (PDC) in hyperprolactinemic (HPRL) women compared to normal healthy volunteers. Read More

View Article and Full-Text PDF

A case of hyperprolactinaemia in a patient with metastatic melanoma.

Melanoma Res 2021 06;31(3):277-279

Medical Oncology Department, Regional Cancer and Blood Service, Auckland City Hospital.

Ectopic prolactin production from a malignancy is infrequently reported. We report here a 60-year-old gentleman who presented with hyperprolactinaemia (9100 mIU/L) causing expressible galactorrhoea, decreased libido and fatigue thought to be due to ectopic prolactin secretion from a metastatic melanoma. Upon initiation of pembrolizumab, the patient's symptoms resolved and he became normoprolactinaemic. Read More

View Article and Full-Text PDF

Macroprolactin: From laboratory to clinical practice.

Endocrinol Diabetes Nutr (Engl Ed) 2021 Apr 23. Epub 2021 Apr 23.

Servicio de Análisis Clínicos, Hospital Universitario Severo Ochoa, Leganés, Madrid, España. Electronic address:

Prolactin measurement is very common in standard clinical practice. It is indicated not only in the study of pituitary adenomas, but also when there are problems with fertility, decreased libido, or menstrual disorders, among other problems. Inadequate interpretation of prolactin levels without contextualizing the laboratory results with the clinical, pharmacological, and gynecological/urological history of patients leads to erroneous diagnoses and, thus, to poorly based studies and treatments. Read More

View Article and Full-Text PDF

Adverse body composition and lipid parameters in patients with prolactinoma: a case-control study.

BMC Endocr Disord 2021 Apr 26;21(1):81. Epub 2021 Apr 26.

Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.

Background: Hyperprolactinaemia might cause adverse metabolic effects. The aim of our study was to compare parameters of body composition, glucose and lipid metabolism between untreated patients with prolactinoma and controls and to assess changes after initiation of cabergoline.

Methods: Case-control study with a retrospectively analyzed follow-up in patients with prolactinoma after initiation of cabergoline therapy. Read More

View Article and Full-Text PDF

Prolactin, metabolic and immune parameters in naïve subjects with a first episode of psychosis.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Apr 21;110:110332. Epub 2021 Apr 21.

Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Madrid, Spain; Department of Psychiatry, School of Medicine, University Hospital Virgen del Rocio-IBIS, Sevilla, Spain.

Background: Prolactin (Prl) is a pleiotropic hormone initially described for its regulation of lactation in mammals but later associated with metabolic and immune homeostasis, stress, inflammatory response and human behavior. Its regulation through dopamine receptors highlights its importance in psychiatry mostly because hyperprolactinemia is a common secondary side effect of dopamine antagonists. Despite its undeciphered patho-physiological mechanisms, hyperprolactinemia in naïve psychosis patients has been widely described. Read More

View Article and Full-Text PDF

Is Adjunct Aripiprazole Effective in Treating Hyperprolactinemia Induced by Psychotropic Medication? A Narrative Review.

CNS Drugs 2021 May 20;35(5):507-526. Epub 2021 Apr 20.

East London Foundation NHS Trust, Glen Road, Cherry Tree Way, Newham, London, E13 8SP, UK.

Psychotropic medication treatment can cause elevated serum prolactin levels and hyperprolactinaemia (HPRL). Reports have suggested that aripiprazole may decrease elevated prolactin. The aim of this review was to assess evidence for the efficacy of adjunct aripiprazole in the treatment of psychotropic-induced HPRL. Read More

View Article and Full-Text PDF

The utility of prolactin serial sampling and the best prolactin cut-offs associated with persistent hyperprolactinemia.

Porto Biomed J 2021 Mar-Apr;6(2):e133. Epub 2021 Apr 13.

Endocrinology Department.

Background: A single prolactin sampling is recommended for the diagnosis of hyperprolactinemia. We aimed to study the utility of the prolactin serial sampling and to determine the best cut-offs associated with persistent hyperprolactinemia.

Methods: Retrospective study of hyperprolactinemic patients [referral prolactin (rPRL)] that underwent prolactin serial samplings. Read More

View Article and Full-Text PDF

A Nonfunctioning Pituitary Macroadenoma Presenting as Cyclical Vomiting and Severe Hyponatremia in a Young Female.

Case Rep Endocrinol 2021 31;2021:5570539. Epub 2021 Mar 31.

Sri Jayewardenepura General Hospital, Nugegoda, Colombo, Sri Lanka.

Introduction: Recurrent vomiting is a commonly overlooked debilitating symptom which causes significant impact on the quality of life. There are several causes for vomiting, ranging from commonly known causes to rare causes. Nonfunctioning pituitary macroadenomas generally present with visual disturbances, headache, and symptoms due to anterior pituitary hormone deficiencies. Read More

View Article and Full-Text PDF

Autoimmune Concept of Schizophrenia: Historical Roots and Current Facets.

Psychiatr Danub 2021 ;33(1):3-17

Laboratory of Mosaic of Autoimmunity, Saint-Peterburg State University, Department of Psychiatry and Addiction, Saint-Petersburg, Russia,

Background: The review analyzes the possible role of autoimmune processes in the pathogenesis of schizophrenia and the evolution of concepts on this issue from its origin to the present.

Results: Risks of autoimmune processes causing schizophrenia are associated with several factors: an impaired functioning of dopaminergic and glutamatergic systems in the brain, kynurenine pathway disorder with overproduction of quinolinic, anthranilic, and kynurenic acids (possibly altering both neurons and T-regulators), increased intestinal permeability, as well as food antigens' effects, stress and infections with various pathogens at different stages of ontogenesis. An increase in the levels of proinflammatory cytokines and chemokines as well as a decrease in the levels of anti-inflammatory ones also may contribute to schizophrenia risks. Read More

View Article and Full-Text PDF