6,830 results match your criteria Hyperprolactinemia


Prolactin and alteration of fertility.

Ceska Gynekol 2018 ;83(3):232-235

Aim: Physiology and pathology of prolactin production, clinical consequences.

Design: Review.

Setting: Reprogenesis International, Brno. Read More

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January 2018

Long-term control of macroprolactinomas.

Expert Rev Endocrinol Metab 2008 May;3(3):361-376

a Professor of Endocrinology, Chief, Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas, University of Sao Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar 155-Predio dos Ambulatorios-8o andar-bloco3. CEP: 05403-900, Sao Paulo, SP, Brazil.

Hyperprolactinemia is the most prevalent hypothalamic-pituitary dysfunction, with prolactinomas being its main cause. Microprolactinomas (diameter < 10 mm) represent approximately 60% of the prolactin-secreting adenomas, and are far more common in women than in men, whereas macroadenomas have roughly the same prevalence in both genders. The treatment of patients harboring macroprolactinomas is highly gratifying, with more than 80% of them adequately controlled by dopamine-agonist (DA) drugs: cabergoline being the most efficacious to date. Read More

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http://www.tandfonline.com/doi/full/10.1586/17446651.3.3.361
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http://dx.doi.org/10.1586/17446651.3.3.361DOI Listing
May 2008
1 Read

Retrospective Analysis of the Effectiveness and Tolerability of Long-Acting Paliperidone Palmitate Antipsychotic in Adolescent First-Episode Schizophrenia Patients.

J Child Adolesc Psychopharmacol 2019 Feb 13. Epub 2019 Feb 13.

1 Department of Child and Adolescent Psychiatry, Clinical Hospital Centre Rijeka, Rijeka, Croatia.

Objective: The aim of this study was to explore the effectiveness and tolerability of long-acting paliperidone palmitate antipsychotic in adolescent first-episode schizophrenia patients while comparing the results with the oral antipsychotic risperidone.

Methods: This study is a retrospective, noninterventional study to assess the effectiveness and tolerability of long-acting injectable antipsychotic paliperidone palmitate in first-episode adolescent patients during the first 12 months of treatment compared with the oral antipsychotic risperidone. The data include general sociodemographic characteristics, number of hospitalizations, side effects, and the following clinical scales: Positive and Negative Syndrome Scale (PANSS), Personal and Social Performance Scale (PSP), Clinical Global Impression Improvement and Severity (CGI-I and CGI-S), and Treatment Satisfaction Questionnaire for Medication (TSQM). Read More

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http://dx.doi.org/10.1089/cap.2018.0044DOI Listing
February 2019

Diagnosis, misdiagnosis and management of hyperprolactinemia.

Expert Rev Endocrinol Metab 2006 Jan;1(1):123-132

c St Vincent's University Hospital, Department of Endocrinology, Elm Park, Dublin 4, Ireland.

Hyperprolactinemia is a commonly encountered disorder that suppresses both male and female gonadal function. The etiology includes pituitary tumors, hypothalamic or pituitary stalk lesions, drugs and hypothyroidism. In women, the hyperprolactinemic syndrome is characterized by menstrual disorders with or without galactorrhea, while men present with hypogonadism and related symptoms. Read More

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http://dx.doi.org/10.1586/17446651.1.1.123DOI Listing
January 2006

Hypothalamic-pituitary-gonadal axis dysfunction: an innate pathophysiology of schizophrenia?

Authors:
X Du R A Hill

Gen Comp Endocrinol 2019 Feb 9. Epub 2019 Feb 9.

Behavioural Neuroscience Laboratory, Department of Psychiatry, Monash University, Clayton, Victoria, 3168, Australia.

The female hormone 17β-estradiol is postulated to be protective against schizophrenia onset and severity. Hypoestrogenism is a common phenomenon in women with schizophrenia that has serious effects that adds to the burden of an already very onerous disease. The cause of hypoestrogenism is largely attributed to antipsychotic-induced hyperprolactinemia. Read More

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http://dx.doi.org/10.1016/j.ygcen.2019.02.009DOI Listing
February 2019

Personalized strategies in reproductive medicine for patients with endocrine disorders.

Ter Arkh 2018 Apr;90(4):81-84

Endocrine Medical Research center, Ministry of Health of Russia, Moscow, Russia.

Endocrine Medical Research center (EMRC) of the Ministry of health of Russia is unique clinical center, that have no analogs in the world. All forms of endocrine disorders may be diagnosed and treated here by implication of innovative methods. Institute of reproductive medicine of EMRC was open on 2017, director of this institute - MD, PhD E. Read More

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http://dx.doi.org/10.26442/terarkh201890481-84DOI Listing
April 2018
1 Read

Comparative evaluation of neuroendocrine dysfunction in children with craniopharyngiomas before and after mass effects are removed.

J Pediatr Endocrinol Metab 2019 Feb;32(2):127-133

Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, P.R. China, Phone: +13661307913.

Objective To compare the effects of mass effects in situ (MEIS) and after neurosurgery (ANS) on neuroendocrine function in children with craniopharyngioma. Methods We retrospectively investigated 185 cases of children with craniopharyngioma who underwent neurosurgical treatment at the Beijing Tiantan Hospital from 2011 to 2016. The neuroendocrine function of patients was compared before and after tumor removal. Read More

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http://dx.doi.org/10.1515/jpem-2018-0204DOI Listing
February 2019
1 Read

Metabolic syndrome and endocrine status in HIV-infected transwomen.

AIDS 2019 Jan 16. Epub 2019 Jan 16.

Infectious and Tropical Diseases Department, Hôpitaux Universitaires Paris Nord Val de Seine (HUPNVS), AP-HP, Paris, France.

Background: HIV-infected transwomen face multiple specific issues. Economic and social marginalization, sex work, substance abuse, hormonal consumption and silicone injection may affect the course of HIV infection and lead to metabolic and endocrine complications.

Methods: A matched case-control study was performed between 2013 and 2015 in a University Hospital and compared metabolic syndrome, thyroid and adrenal functions in HIV-infected transwomen (i. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002152DOI Listing
January 2019
2 Reads

Impact of hyperprolactinemia in a patient with polyautoimmunity.

Clin Case Rep 2019 Jan 9;7(1):19-23. Epub 2018 Nov 9.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences Universidad del Rosario Bogota Colombia.

Hyperprolactinemia has been proposed as a triggering factor for autoimmune diseases. The increased levels of prolactin could induce an abnormal immune response. Herein, we present a patient with hyperprolactinemia who developed polyautoimmunity. Read More

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http://dx.doi.org/10.1002/ccr3.1900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333117PMC
January 2019
1 Read

Prolactin, autoimmunity, and motherhood: when should women avoid breastfeeding?

Clin Rheumatol 2019 Jan 11. Epub 2019 Jan 11.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv University, 5265601, Tel Hashomer, Israel.

The sexual dimorphic prevalence of autoimmunity represents one of the most alluring observations among the mosaic of autoimmunity. Sex hormones are believed to be a mainstay of this asymmetry. The greater prevalence of autoimmunity among fertile women, disease onset/relapses during pregnancy, and postpartum are some of the points that support this theory. Read More

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http://link.springer.com/10.1007/s10067-018-04415-y
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http://dx.doi.org/10.1007/s10067-018-04415-yDOI Listing
January 2019
9 Reads

Effect of Kisspeptin on Serum Prolactin and Gonadotropins Levels in Balb-c Mice with Induced Chronic Stress.

J Coll Physicians Surg Pak 2019 Jan;29(1):41-44

Department of Physiology, Shifa College of Medicine, Islamabad, Pakistan.

Objective: To determine and compare effects of kisspeptin on serum prolactin, luteinizing hormone and follicle stimulating hormone levels in Balb-c mice with and without exposure to chronic restraint stress.

Study Design: An animal experimental study.

Place And Duration Of Study: Shifa College of Medicine / Shifa International Hospital Islamabad, in collaboration with National Institute of Health, Islamabad and Centre for Research in Experimental and Applied Medicine Laboratory, Army Medical College, Rawalpindi, from April 2014 to June 2015. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.01.41DOI Listing
January 2019
1 Read

Clinical Presentation and Pathologic Characteristics of Pituitary Metastasis from Breast Carcinoma: Cases and a Systematic Review of the Literature.

World Neurosurg 2019 Jan 7. Epub 2019 Jan 7.

Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China. Electronic address:

Background: It is rare for breast carcinoma to metastasize to the pituitary gland; this finding indicates extensive metastasis of the primary tumor.

Case Description: Herein, we present a 57-year-old patient with pituitary gland metastasis from breast cancer that was treated with extensive radical mastectomy 16 years prior. The pituitary was the sole site of metastasis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183294
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http://dx.doi.org/10.1016/j.wneu.2018.12.126DOI Listing
January 2019
9 Reads

Antipsychotic use and fracture risk: An evaluation of incidence at a Veterans Affairs medical center.

Ment Health Clin 2019 Jan 4;9(1):6-11. Epub 2019 Jan 4.

Introduction: Recent meta-analyses have found a correlation between schizophrenia and increased fracture risk with one contributing factor potentially being antipsychotic-induced hyperprolactinemia, which may accelerate bone turnover. The objective of this study is to evaluate fracture rates in patients on long-term antipsychotic therapy to see if screening for osteoporosis should be included with routine monitoring.

Methods: Patients exposed to antipsychotics for ≥3 months during a 10-year study period were included in this retrospective analysis. Read More

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http://dx.doi.org/10.9740/mhc.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322822PMC
January 2019
2 Reads

Suprasellar chordoid glioma: a report of two cases.

Arch Endocrinol Metab 2018 ;62(6):648-654

Instituto de Investigaciones Neurológicas "Dr. Raúl Carrea", FLENI, Pathology, Buenos Aires, Argentina.

Chordoid glioma (CG) is considered a slow growing glial neoplasm. We report two new cases with endocrinological presentation, management and outcome. Case reports: 1) An 18 year-old female patient was admitted due to headaches, nausea and vomiting and visual abnormalities. Read More

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http://dx.doi.org/10.20945/2359-3997000000092DOI Listing
February 2019
2 Reads

Association of raised levels of IL-4 and anti-TPO with hyperprolactinemia.

Am J Reprod Immunol 2019 Jan 4:e13085. Epub 2019 Jan 4.

Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.

Background And Objective: The modulatory role of prolactin in autoimmune regulation is well established. Hyperprolactinemia is often associated with autoimmune disease like systemic lupus erythematosus and autoimmune thyroid diseases. The objective was to compare levels of direct and indirect autoimmune factors in different categories of hyperprolactinemia cases and predict the direction of association between hyperprolactinemia and autoimmune factors, if any. Read More

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http://dx.doi.org/10.1111/aji.13085DOI Listing
January 2019
3 Reads

Estimation of serum prolactin levels and determination of prevalence of hyperprolactinemia in newly diagnosed cases of subclinical hypothyroidism.

J Family Med Prim Care 2018 Nov-Dec;7(6):1279-1282

Department of Medicine, SBAMI, New Delhi, India.

Background: Hyperprolactinemia is a common endocrine disorder involving hypothalamic-pituitary axis. Prolactin (PRL) secretion is stimulated by dopamine antagonism and thyroid-releasing hormone. Hyperprolactinemia has been reported in subclinical hypothyroidism (SCH) but results are markedly variable and studies on SCH are very few. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_155_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293902PMC
January 2019
1 Read

The effect of prolactin itself and in combination with estrogen on bone mineral density in female rats.

Gynecol Endocrinol 2019 Jan 1:1-5. Epub 2019 Jan 1.

a Shiraz Endocrinology and Metabolism Research Center , Shiraz University of Medical Sciences , Shiraz , Iran.

Estrogen deficiency induced by hyperprolactinemia can reduce bone mineral density. Hyperprolactinemia through other mechanisms other than estrogen deficiency, with direct effect on the bone might cause bone loss in women. The present study evaluated the effect of prolactin itself and in combination with estrogen on bone mineral density of female rats. Read More

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http://dx.doi.org/10.1080/09513590.2018.1548592DOI Listing
January 2019
1 Read

The relation of serum prolactin levels and infection in humans.

Int J Gen Med 2019 20;12:7-12. Epub 2018 Dec 20.

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran,

Background: is an intracellular protozoan parasite distributed worldwide. Although the infection is benign in immunocompetent individuals, it is life threatening and complicated in immunocompromised patients and fetuses of pregnant women who received their first exposure to during the pregnancy. Prolactin (PRL) is a hormone that is secreted by the pituitary gland, and it is confirmed that it plays a role in the immune system. Read More

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https://www.dovepress.com/the-relation-of-serum-prolactin-le
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http://dx.doi.org/10.2147/IJGM.S188525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304245PMC
December 2018
13 Reads

Rapid-Onset Obesity with Hypoventilation, Hypothalamic, Autonomic Dysregulation, and Neuroendocrine Tumors (ROHHADNET) Syndrome: A Systematic Review.

Biomed Res Int 2018 21;2018:1250721. Epub 2018 Nov 21.

Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background And Aim: ROHHADNET (rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, neuroendocrine tumor) syndrome is a rare disease with grave outcome. Although early recognition is essential, prompt diagnosis may be challenging due to its extreme rarity. This study aimed to systematically review its clinical manifestation and to identify genetic causes. Read More

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https://www.hindawi.com/journals/bmri/2018/1250721/
Publisher Site
http://dx.doi.org/10.1155/2018/1250721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280256PMC
November 2018
2 Reads

Pyridoxine for the treatment of quetiapine-induced hyperprolactinemia and amenorrhea: A case report.

Schizophr Res 2018 Dec 21. Epub 2018 Dec 21.

The Mental Rehabilitation Centers, Karamay Municipal People's Hospital, Karamay, Xinjiang 830054, China.

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http://dx.doi.org/10.1016/j.schres.2018.12.008DOI Listing
December 2018
8 Reads

Adjunctive Peony-Glycyrrhiza decoction for antipsychotic-induced hyperprolactinaemia: a meta-analysis of randomised controlled trials.

Gen Psychiatr 2018 8;31(1):e100003. Epub 2018 Sep 8.

Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macau, China.

Background: Hyperprolactinaemia is a common adverse effect of antipsychotics (APs). The results of Peony-Glycyrrhiza decoction (PGD) as a potentially useful adjunctive treatment for hyperprolactinaemia are inconsistent.

Aim: This meta-analysis of randomised controlled trials (RCTs) examined the efficacy and safety of adjunctive PGD therapy for AP-induced hyperprolactinaemia. Read More

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http://dx.doi.org/10.1136/gpsych-2018-100003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211273PMC
September 2018
1 Read

Variant Prolactin Receptor in Agalactia and Hyperprolactinemia.

N Engl J Med 2018 12;379(23):2230-2236

From the Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba (T.K., H.U., H.T., M.S.), and the Department of Obstetrics and Gynecology, School of Medicine, International University of Health and Welfare, Narita (H.T.) - both in Japan.

A loss-of-function variant in the gene encoding the prolactin receptor ( PRLR) was reported previously in a woman with persistent postpartum galactorrhea; however, this paradoxical phenotype is not completely understood. Here we describe a 35-year-old woman who presented with idiopathic hyperprolactinemia that was associated with a complete lack of lactation after each of her two deliveries. She is a compound heterozygote for loss-of-function variants of PRLR. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1805171
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http://dx.doi.org/10.1056/NEJMoa1805171DOI Listing
December 2018
13 Reads

The association between serum prolactin levels and interleukin-6 and systemic lupus erythematosus activity.

Reumatismo 2018 Dec 20;70(4):241-250. Epub 2018 Dec 20.

University Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur.

Based on the recent evidence of association between hyperprolactinemia and systemic lupus erythematosus disease activity (SLEDAI), a study was conducted to analyze the association of hyperprolactinemia with lupus nephritis disease activity. In this cross-sectional study, the analysis was conducted on SLE patients who visited the University Kebangsaan Malaysia Medical Centre (UKMMC) Nephrology Clinic from August 2015 till February 2016. The disease activity was measured using the SLEDAI score, with more than 4 indicating active lupus nephritis. Read More

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http://dx.doi.org/10.4081/reumatismo.2018.1075DOI Listing
December 2018
1 Read

Effect of Brexpiprazole on Prolactin: An Analysis of Short- and Long-Term Studies in Schizophrenia.

J Clin Psychopharmacol 2019 Jan/Feb;39(1):13-19

Otsuka Pharmaceutical Development & Commercialization Inc, Princeton, NJ.

Background: Hyperprolactinemia is an undesirable effect of most antipsychotics because of D2-receptor blockade. We assessed the effect of the D2-receptor partial agonist brexpiprazole on prolactin, based on pooled data from three 6-week, randomized, placebo-controlled studies and two open-label extension studies in patients with schizophrenia.

Methods: In the short-term studies, patients received 0. Read More

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http://dx.doi.org/10.1097/JCP.0000000000000979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319696PMC
December 2018
3 Reads

Prolonged ovarian acyclicity is associated with a higher likelihood of developing hyperprolactinemia in zoo female African elephants.

Zoo Biol 2018 Dec 18. Epub 2018 Dec 18.

Department of Reproductive Sciences, Center for Species Survival, Smithsonian Conservation Biology Institute, Front Royal, Virginia.

Hyperprolactinemia is a common disorder of the hypothalamic-pituitary axis, and a cause of ovarian dysfunction in women. Currently, over half of non-cycling African elephant females in North America also are hyperprolactinemic, suggesting a similar link between these two conditions may exist. The objective of this study was to determine the relationship between acyclicity and prolactin status by comparing mean prolactin concentrations of bi-weekly samples collected over a 1-year period in 2012 with 20 years of historical weekly progestagen data to assess cyclicity. Read More

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http://dx.doi.org/10.1002/zoo.21464DOI Listing
December 2018
1 Read

Prolactin and Thyroid Stimulating Hormone (TSH) Levels and Sexual Dysfunction in Patients with Schizophrenia Treated with Conventional Antipsychotic Medication: A Cross-Sectional Study.

Med Sci Monit 2018 Dec 16;24:9136-9143. Epub 2018 Dec 16.

Sixth Affiliated Hospital, Kunming Medical University, Yuxi, Yunnan, China (mainland).

BACKGROUND This study aimed to investigate the relationship between serum profiles of prolactin and thyroid stimulating hormone (TSH) and sexual dysfunction in patients with schizophrenia treated with conventional antipsychotic medication. MATERIAL AND METHODS A hospital-based cross-sectional study included 118 patients, age range 18-57 years (55 men, 63 women), with a confirmed diagnosis of schizophrenia. All patients were stable after antipsychotic treatment. Read More

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https://www.medscimonit.com/abstract/index/idArt/913759
Publisher Site
http://dx.doi.org/10.12659/MSM.913759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319142PMC
December 2018
21 Reads

Sexual dysfunction factors in patients with schizophrenia treated with second generation antipsychotics: not only prolactin.

Actas Esp Psiquiatr 2018 Nov 1;46(6):217-25. Epub 2018 Nov 1.

Unidad de Gestión Clínica de Salud Mental. Hospital Universitario de Valme. Sevilla. España.

Introduction: Despite the high prevalence of sexual dysfunction in patients with schizophrenia, its origins are still unclear.

The Aim Of This Study: to determine the prevalence and causal factors of sexual dysfunction in a group of outpatients with schizophrenia.

Methods: The study was designed to be cross-sectional and naturalistic, including outpatients with schizophrenia undergoing second generation antipsychotic monotherapy. Read More

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November 2018
1 Read

Prolactinomas Resistant to Treatment With Dopamine Agonists: Long-Term Follow-Up of Six Cases.

Front Endocrinol (Lausanne) 2018 13;9:625. Epub 2018 Nov 13.

Endocrinology Service, Brasilia University Hospital, Brasília, Brazil.

Prolactinomas are preferentially treated with dopamine agonists. However, a few adenomas are resistant to this treatment. To evaluate the characteristics of patients with resistance to dopamine agonists in the long-term. Read More

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http://dx.doi.org/10.3389/fendo.2018.00625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277870PMC
November 2018
1 Read

Effects on Satisfaction and Service Engagement of Paliperidone Palmitate Compared with Oral Paliperidone in Patients with Schizophrenia: An Open Label Randomized Controlled Trial.

Clin Drug Investig 2018 Dec 6. Epub 2018 Dec 6.

Department of Neuroscience, "Rita Levi Montalcini", University of Turin, Turin, Italy.

BACKGROUND AND OBJECTIVE: Clinical practice guidelines recommend antipsychotic monotherapy, including oral and long-acting formulations, in the treatment of schizophrenia. This open-label, randomized, controlled trial aimed to evaluate the efficacy and tolerability in patients with schizophrenia of once-monthly long-acting paliperidone palmitate (PP1M) compared with oral paliperidone extended release (ER), with a particular focus on satisfaction, subjective well-being, and service engagement.

Methods: Seventy-two consecutive outpatients with schizophrenia (DSM-5) were randomly assigned for 6 months to: (1) PP1M (50-150 mg equivalent) or (2) paliperidone ER (6-12 mg/day). Read More

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http://dx.doi.org/10.1007/s40261-018-0734-1DOI Listing
December 2018
5 Reads

Antipsychotics and pituitary tumors: an analysis of the European pharmacovigilance database (EudraVigilance).

Int Clin Psychopharmacol 2019 Mar;34(2):89-92

Basque Pharmacovigilance Unit, Galdakao-Usánsolo Hospital, Galdakao.

One of the possible long-term consequences of antipsychotic-induced hyperprolactinemia is the development of pituitary tumors - prolactinomas. So far, two pharmacovigilance studies of spontaneous adverse event report databases have suggested an increased risk, whereas a longitudinal study carried out with risperidone showed no evidence of increased risk of tumors with mass effect. Besides, information on amisulpride and paliperidone is lacking. Read More

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http://dx.doi.org/10.1097/YIC.0000000000000247DOI Listing
March 2019
1 Read

Prolactin induces IL-2 associated TRAIL expression on natural killer cells from chronic hepatitis C patients in vivo and in vitro.

Endocr Metab Immune Disord Drug Targets 2018 Dec 6. Epub 2018 Dec 6.

Laboratorio de Hígado, Páncreas y Motilidad (HIPAM) - Unidad de Investigación en Medicina Experimental, Facultad de Medicina, UNAM. Mexico.

Background: Natural killer cells (NKC) are a major component of innate immune response to HCV, mediating their effects through TRAIL and IFN-γ. However, their function is diminished in chronic HCV patients (HCVp). Prolactin is an immunomodulatory hormone capable of activating NKC. Read More

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http://dx.doi.org/10.2174/1871530319666181206125545DOI Listing
December 2018
3 Reads

Giant prolactinoma, germline BRCA1 mutation, and depression: a case report.

J Med Case Rep 2018 Dec 6;12(1):360. Epub 2018 Dec 6.

Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, E.P.E., Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.

Background: Giant prolactinomas are very rare pituitary tumors that may exhibit an aggressive behavior and present with a life-threatening condition.

Case Presentation: A 25-year-old white woman was admitted to our hospital with a headache, psychomotor retardation, reduced vision, and loss of autonomy in daily activities. Her past medical history was significant for having oligomenorrhea and a depressive syndrome since her mother's death. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13256-018-1890-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282289PMC
December 2018
13 Reads

ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS.

Front Endocrinol (Lausanne) 2018 15;9:669. Epub 2018 Nov 15.

Center for Reproductive Medicine, School of Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.

Ovulatory disorder is common in patients with hyperprolactinemia or polycystic ovary syndrome (PCOS). Previous studies have shown that ATF4 plays critical role in apoptosis and glucose homeostasis, but its role in regulating reproductive function was not explored. The present study investigated the role of ATF4 in ovarian ovulatory function. Read More

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http://dx.doi.org/10.3389/fendo.2018.00669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249970PMC
November 2018
2 Reads

Bromocriptine-responsive supersellar germinoma with the expression of dopamine receptors: A case report.

Clin Neurol Neurosurg 2019 Jan 10;176:15-18. Epub 2018 Nov 10.

Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197# Ruijin Er Road, Shanghai, 200025, China. Electronic address:

Background: Germinomas are sensitive to radiotherapy and chemotherapy. However, there has been no report involving in the potential therapeutic effect of dopamine agonists (DAs) such as bromocriptine on germinomas.

Case Description: A 20-year-old female was presented with bitemporal visual disturbance and amenorrhea. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467183043
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http://dx.doi.org/10.1016/j.clineuro.2018.11.006DOI Listing
January 2019
13 Reads

Different effects of fenofibrate on cardiometabolic risk factors in young women with and without hyperprolactinemia.

Pharmacol Rep 2018 Sep 6;71(1):61-66. Epub 2018 Sep 6.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Background: Elevated prolactin levels are associated with increased cardiometabolic risk. No previous study has compared the effect of hypolipidemic therapy on plasma levels of lipids and other cardiometabolic risk factors in patients with and without hyperprolactinemia.

Methods: The study included three age-, weight-, blood pressure- and lipid-matched groups of premenopausal women: 18 women with untreated hyperprolactinemia, 19 women with bromocriptine-treated hyperprolactinemia and 20 drug-naïve women with normal prolactin levels. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.09.004DOI Listing
September 2018
9 Reads

Suppression of Prolactin Secretion Partially Explains the Antidiabetic Effect of Bromocriptine in ob/ob Mice.

Endocrinology 2019 Jan;160(1):193-204

Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.

Previous studies have shown that bromocriptine mesylate (Bromo) lowers blood glucose levels in adults with type 2 diabetes mellitus; however, the mechanism of action of the antidiabetic effects of Bromo is unclear. As a dopamine receptor agonist, Bromo can alter brain dopamine activity affecting glucose control, but it also suppresses prolactin (Prl) secretion, and Prl levels modulate glucose homeostasis. Thus, the objective of the current study was to investigate whether Bromo improves insulin sensitivity via inhibition of Prl secretion. Read More

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http://dx.doi.org/10.1210/en.2018-00629DOI Listing
January 2019
12 Reads

Galactocele of adult male breast: A cytopathologist's perspective.

Diagn Cytopathol 2019 Feb 21;47(2):134-136. Epub 2018 Nov 21.

Dr. Datta's Clinic, Chandannagar, Hooghly, India.

Galactocele, although a common cytological diagnosis in females, is not previously reported as a cause of breast enlargement in adult males. Hyperprolactinemia is the principal cause of galactocele in male breast. Besides drug induced hyperprolactinemia, other anatomical lesions of hypothalamo-pituitary region and different medical conditions like cirrhosis and chronic kidney disease are to be considered along with a full evaluation of features revealing hypogonadism in case of galactocele. Read More

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http://dx.doi.org/10.1002/dc.24101DOI Listing
February 2019
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Galactocele After Aesthetic Breast Augmentation with Silicone Implants: An Uncommon Presentation.

Aesthetic Plast Surg 2018 Nov 19. Epub 2018 Nov 19.

Unit of Plastic Surgery, Sapienza University of Rome, Rome, Italy.

Background: Breast augmentation is one of the most frequently performed esthetic operations. Galactorrhea and galactocele formation are both very rare complications. The real cause still remains unknown, but various risk factors have been well reported in the literature. Read More

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http://link.springer.com/10.1007/s00266-018-1266-z
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http://dx.doi.org/10.1007/s00266-018-1266-zDOI Listing
November 2018
18 Reads

Dopamine D receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia.

Neuropsychopharmacology 2019 Feb 26;44(3):598-605. Epub 2018 Oct 26.

Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Dopamine D receptor occupancy (DRO) is a key feature of all currently approved antipsychotic medications. However, antipsychotic efficacy associated with high DRO is often limited by side effects such as motor disturbances and hyperprolactinemia. Lumateperone (ITI-007) is a first-in-class selective and simultaneous modulator of serotonin, dopamine and glutamate in development for the treatment of schizophrenia and other disorders. Read More

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http://www.nature.com/articles/s41386-018-0251-1
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http://dx.doi.org/10.1038/s41386-018-0251-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333832PMC
February 2019
13 Reads

CHANGE OF CENTRAL AND PERIPHERAL VISION IN PATIENT WITH SYMPTOMATIC CYST OF RATHKE'S CLEFT FOLLOWING TRANSSPHENOIDAL RESECTION.

Cesk Slov Oftalmol 2018 ;74(2):73-78

A seventysix-year-old female was acutely admitted to the Eye Clinic of the University Hospital in Martin with a 1 month history of impaired central and peripheral vision on the right eye. At the admission patient`s right eye VA was fingers at 20 cm, the left eye had a central vision preserved. Magnetic resonance of the brain and orbits demonstrated cystic tumor expansion in the sellar region with compression of optic chiasm and optic nerves (more on the right side), in diff. Read More

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http://dx.doi.org/10.31348/2018/1/5-2-2018DOI Listing
January 2018
1 Read

Hormonal Risk Factors for Osteoporosis: Different Profile Among Antipsychotics.

J Child Adolesc Psychopharmacol 2018 Nov 13. Epub 2018 Nov 13.

1 Department of Child and Adolescent Psychiatry, Assistance Publique-Hôpitaux de Paris, University Hospital Pitié-Salpêtrière , Paris, France .

Objectives: Osteoporosis is a major risk factor for fracture and treatment is mainly preventive. Patients with severe psychiatric condition and treated with antipsychotics are at risk for vitamin D deficiency and iatrogenic hyperprolactinemia, two serious risk factors of osteoporosis. We aim to determine whether all antipsychotics are similar regarding the risk of osteoporosis in young patients. Read More

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http://dx.doi.org/10.1089/cap.2017.0158DOI Listing
November 2018
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Psychological effects of Dopamine Agonist Treatment in Patients with Hyperprolactinemia and Prolactin Secreting Adenomas.

Eur J Endocrinol 2018 Oct 1. Epub 2018 Oct 1.

L Katznelson, Department of Medicine, Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, Stanford, United States.

Background: Dopamine agonists (DAs) are the main treatment for patients with hyperprolactinemia and prolactinomas. Recently, an increasing number of reports emphasized DAs' psychological side effects, either de- novo or as exacerbations of prior psychiatric disease.

Methods: Review of prospective and retrospective studies (PubMed 1976- September 2018) evaluating the psychological profile of DAs-treated patients with hyperprolactinemia and prolactinomas. Read More

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https://eje.bioscientifica.com/view/journals/eje/aop/eje-18-
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http://dx.doi.org/10.1530/EJE-18-0682DOI Listing
October 2018
7 Reads

Chronic estrogen affects TIDA neurons through IL-1β and NO: effects of aging.

J Endocrinol 2018 Nov 1. Epub 2018 Nov 1.

P MohanKumar, Veterinary Biosciences and Diagnostic Imaging, University of Georgioa, Athens, United States.

Women are chronically exposed to estrogens through oral contraceptives, hormone replacement therapy or environmental estrogens. We hypothesized that chronic exposure to low levels of estradiol-17β (E2) can induce inflammatory and degenerative changes in the tuberoinfundibular dopaminergic (TIDA) system leading to reduced dopamine synthesis and hyperprolactinemia. Young (Y; 3-4 months) and middle-aged (MA; 10-12 months) Sprague-Dawley rats that were intact or ovariectomized (OVX), were either sham-implanted or implanted with a slow-release E2 pellet (20ng E2/day for 90 days). Read More

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https://joe.bioscientifica.com/view/journals/joe/aop/joe-18-
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http://dx.doi.org/10.1530/JOE-18-0274DOI Listing
November 2018
12 Reads

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey.

J Clin Res Pediatr Endocrinol 2018 Nov 5. Epub 2018 Nov 5.

Objective: We aimed to study the characteristics on admission, diagnosis, treatment, and follow-up of hyperprolactinemic cases in a large multicenter study.

Methods: We reviewed 233 hyperprolactinemic patients under 18 years of age who were followed by different centers. The patients were divided as having microadenomas, macroadenomas, drug-induced hyperprolactinemia, and idiopathic hyperprolactinemia. Read More

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http://cms.galenos.com.tr/Uploads/Article_19906/JCRPE-0-0-En
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http://dx.doi.org/10.4274/jcrpe.0206DOI Listing
November 2018
7 Reads

Giant Prolactinoma in Men: Clinical Features and Therapeutic Outcomes.

Horm Metab Res 2018 Nov 5;50(11):791-796. Epub 2018 Nov 5.

Department of Endocrinology, Hospital Universitario Ramón y Cajal, Madrid, Spain.

The aim of the study was to evaluate the clinical features and long-term therapeutic outcome of giant prolactinoma (gPRLoma) in men and to compare them with those of a group of male patients with non-gPRL macroprolactinomas (non-gPRLomas). A retrospective and multicenter study of gPRLomas in men diagnosed in a 20-year period was performed. Clinical data and treatment outcome were registered. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0752-0741
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http://dx.doi.org/10.1055/a-0752-0741DOI Listing
November 2018
20 Reads

Ca2+ Channels in Anterior Pituitary Somatotrophs: A Therapeutic Perspective.

Endocrinology 2018 Dec;159(12):4043-4055

Department of Medical Neurobiology, Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University Faculty of Medicine, Jerusalem, Israel.

Ca2+ influx through voltage-gated Ca2+ channels (VGCCs) plays a key role in GH secretion. In this review, we summarize the current state of knowledge regarding the physiology and molecular machinery of VGCCs in pituitary somatotrophs. We next discuss the possible involvement of Ca2+ channelopathies in pituitary disease and the potential use of Ca2+ channel blockers to treat pituitary disease. Read More

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https://academic.oup.com/endo/advance-article/doi/10.1210/en
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http://dx.doi.org/10.1210/en.2018-00743DOI Listing
December 2018
6 Reads