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    6644 results match your criteria Hyperprolactinemia

    1 OF 133

    Prevalence and risk factors of hyperprolactinemia among patients with various psychiatric diagnoses and medications.
    Int J Psychiatry Clin Pract 2018 Jan 15:1-8. Epub 2018 Jan 15.
    g Mental Health Hospital , Abha , Saudi Arabia.
    Objectives: Hyperprolactinemia is a common adverse event associated with psychotropic medications (mainly antipsychotics) used in the management of schizophrenia and bipolar disorders. The aim of this study was to estimate the prevalence of hyperprolactinemia in psychiatric patients and to evaluate its association with various psychiatric diagnoses and the use of various psychotropic medications.

    Methods: A cross-sectional observational study was conducted between July 2012 and June 2014. Read More

    From Bench to Bedside: Translating the Prolactin/Vasoinhibin Axis.
    Front Endocrinol (Lausanne) 2017 11;8:342. Epub 2017 Dec 11.
    Institute for Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Nuremberg General Hospital, Paracelsus Medical University, Nuremberg, Germany.
    The prolactin/vasoinhibin axis defines an endocrine system, in which prolactin (PRL) and vasoinhibins regulate blood vessel growth and function, the secretion of other hormones, inflammatory and immune processes, coagulation, and behavior. The core element of the PRL/vasoinhibin axis is the generation of vasoinhibins, which consists in the proteolytic cleavage of their precursor molecule PRL. Vasoinhibins can interact with multiple different partners to mediate their effects in various tissues and anatomical compartments, indicating their pleiotropic nature. Read More

    Effect of Peony-Glycyrrhiza Decoction on Amisulpride-Induced Hyperprolactinemia in Women with Schizophrenia: A Preliminary Study.
    Evid Based Complement Alternat Med 2017 26;2017:7901670. Epub 2017 Nov 26.
    Department of Psychiatry, Brains Hospital of Hunan Province, Changsha, China.
    Objective: The aim of this study is to observe the effect of Peony-Glycyrrhiza Decoction (PGD) on hyperprolactinemia in women with schizophrenia induced by Amisulpride.

    Material And Methods: A total of 41 female schizophrenia patients receiving Amisulpride were randomly divided into placebo (n = 20) and PGD groups (n = 21). Maintaining the original Amisulpride dose, the two groups were given placebo and PGD, respectively. Read More

    Prescribing Trends of Atypical Antipsychotic Drugs in an Outpatient Unit of a Child and Adolescent Clinic in Turkey.
    Clin Neuropharmacol 2018 Jan/Feb;41(1):23-27
    Objective: Use of antipsychotic agents in the management of various psychopathologies in Child and Adolescent Psychiatric practice is gradually increasing. This study aimed to evaluate the sociodemographic and clinical features of children and adolescents who applied to an outpatient clinic of child and adolescent psychiatry department in Turkey and were prescribed atypical antipsychotics.

    Method: Patients with prescription codes of ATC N05A (except N05AN lithium) were accepted to denote those with atypical antipsychotic treatment. Read More

    Quetiapine reverses paclitaxel-induced neuropathic pain in mice: Role of alpha2- adrenergic receptors.
    Iran J Basic Med Sci 2017 Nov;20(11):1182-1188
    Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.
    Objectives: Paclitaxel-induced peripheral neuropathy is a common adverse effect of cancer chemo -therapy. This neuropathy has a profound impact on quality of life and patient's survival. Preventing and treating paclitaxel-induced peripheral neuropathy is a major concern. Read More

    Broad clinical spectrum and diverse outcomes of prolactinoma with pediatric onset: medication-resistant and recurrent cases.
    Endocr J 2017 Dec 27. Epub 2017 Dec 27.
    Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
    Prolactinoma is a benign tumor of the pituitary gland that rarely occurs in children and adolescents; thus, the clinical spectrum and long-term prognosis in these patients remain unknown. This study was performed to investigate the long-term outcomes of medical treatment and the prognostic factors for remission and relapse in children and adolescents with prolactinoma. Three male subjects and four female subjects between the ages of 7- and 17-years-old were included in this study. Read More

    Higher TSH levels within the normal range are associated with unexplained infertility.
    J Clin Endocrinol Metab 2017 Dec 19. Epub 2017 Dec 19.
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA.
    Context: Unexplained infertility (UI)--defined as the inability to conceive after 12 months of unprotected intercourse with no diagnosed cause--affects 10-30% of infertile couples. An improved understanding of the mechanisms underlying UI could lead to less invasive and less costly treatment strategies. Abnormalities in thyroid function and hyperprolactinemia are well-known causes of infertility, but whether TSH and prolactin levels within the normal range are associated with UI is unknown. Read More

    Prolactinomas: how to handle prior to and during pregnancy?
    Minerva Endocrinol 2017 Dec 21. Epub 2017 Dec 21.
    Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo, Brazil -
    Prolactinomas are the most common cause of pathological hyperprolactinemia, leading to central hypogonadism and, therefore, a frequent etiology of infertility. Treatment, usually with dopamine agonist (DA), can reverse hyperprolactinemia and hypogonadism, allowing pregnancy in the majority of cases. Bromocriptine is still the DA of choice for such purpose. Read More

    Cabergoline Tapering Is Almost Always Successful in Patients With Macroprolactinomas.
    J Endocr Soc 2017 Mar 16;1(3):221-230. Epub 2017 Feb 16.
    Service d'Endocrinologie et des Maladies de la Reproduction and Centre de Référence des Maladies Endocriniennes Rares de la Croissance, and.
    Context: Cabergoline (CAB) is very effective in the treatment of macroprolactinomas, but there are few data on the CAB dose necessary to achieve and maintain normal prolactin (PRL) levels.

    Design And Patients: We retrospectively studied 260 patients. CAB was introduced at a mean dose of 0. Read More

    Hypothalamic-Pituitary-Ovarian Axis Reactivation by Kisspeptin-10 in Hyperprolactinemic Women With Chronic Amenorrhea.
    J Endocr Soc 2017 Nov 16;1(11):1362-1371. Epub 2017 Oct 16.
    Reproductive Endocrinology Department, Le Kremlin-Bicêtre, F-94275, France.
    Context: Hyperprolactinemia-induced hypogonadotropic amenorrhea (hPRL-HA) is a major cause of hypothalamic gonadotrophin-releasing hormone (GnRH) deficiency in women. In hyperprolactinemic mice, we previously demonstrated that hypothalamic kisspeptin (Kp) expression was diminished and that Kp administration restored hypothalamic GnRH release, gonadotropin secretion, and ovarian cyclicity, suggesting that Kp neurons could also play a role in hPRL-HA.

    Objective: To study the effect of Kp-10 on the gonadotropic-ovarian axis in women with hPRL-HA. Read More

    [Analysis of clinical features of 23 patients with POEMS syndrome].
    Beijing Da Xue Xue Bao Yi Xue Ban 2017 Dec;49(6):985-989
    Department of Endocrinology, Peking University People's Hospital, Beijing 100044, China.
    Objective: To describe the endocrine abnormalities in patients with POEMS syndrome in order to identify more patients with POEMS syndrome among those who have endocrine dysfunctions.

    Methods: We searched the inpatient medical record system of Peking University People's Hospital with "POEMS syndrome". Finally the data from 23 patients were analyzed. Read More

    Mass effect: a plethora of symptoms caused by an otherwise benign transitional pituitary meningioma. Case report.
    Rom J Morphol Embryol 2017 ;58(3):983-988
    Department of Plastic Surgery and Reconstructive Microsurgery, Emergency Clinical Hospital of Bucharest, Romania;
    Meningiomas are among the most commonly encountered tumors of the central nervous system, being more frequent in females. We present the case of a dyslipidemic male patient, previously diagnosed with coronary artery disease for which he previously underwent percutaneous coronary intervention with the placement of two bare metal stents on the left anterior descending artery. He was presented to the emergency department for atypical angina and a seven-day history of dizziness when switching from clino- to orthostatism, reduced visual acuity, diplopia and vomiting. Read More

    Impact of Kidney Transplantation on Reproductive Hormone Levels in Males: A Longitudinal Study.
    Nephron 2017 Dec 14. Epub 2017 Dec 14.
    Department of Nephrology, Lund University, Skåne University Hospital, Malmö, Sweden.
    Background/aims: Male patients with end-stage renal disease suffer from sexual disturbances and infertility. Disturbances in the hypothalamic-pituitary-gonadal axis are one of the causes of this. Decreased testosterone synthesis in Leydig cells of the testes and hyperprolactinemia are common. Read More

    Laboratory and clinical significance of macroprolactinemia in women with hyperprolactinemia.
    Taiwan J Obstet Gynecol 2017 Dec;56(6):719-724
    Department of Obstetrics and Gynecology, Cantonal Hospital Zenica, Zenica, Bosnia and Herzegovina.
    The role of macroprolactinemia in women with hyperprolactinemia is currently controversial and can lead to clinical dilemmas, depending upon the origin of macroprolactin, the presence of hyperprolactinemic symptoms and monomeric prolactin (PRL) levels. Macroprolactinemia is mostly considered an extrapituitary phenomenon of mild and asymptomatic hyperprolactinemia associated with normal concentrations of monomeric PRL and a predominance of macroprolactin confined to the vascular system, which is biologically inactive. Patients can therefore be reassured that macroprolactinemia should be considered a benign clinical condition, resistant to antiprolactinemic drugs, and that no diagnostic investigations or prolonged follow-up should be necessary. Read More

    Sex differences in the relationship between prolactin levels and impaired processing speed in early psychosis.
    Aust N Z J Psychiatry 2017 Dec 1:4867417744254. Epub 2017 Dec 1.
    1 Parc Taulí Hospital Universitari, I3PT, Universitat Autònoma de Barcelona, CIBERSAM, Sabadell, Spain.
    Introduction: Hyperprolactinaemia is commonly observed in people with psychotic disorders due to D2 receptor blockade by antipsychotic drugs, although it may also exist in drug-naïve patients with first-episode psychosis. Recent studies suggest that hyperprolactinaemia may have a negative impact on cognitive function in people with early psychosis. We aimed to explore whether there are sex differences in the association between prolactin levels and cognitive performance in early psychosis patients. Read More

    Serum prolactin levels and sexual dysfunction in patients with schizophrenia treated with antipsychotics: comparison between aripiprazole and other atypical antipsychotics.
    Ann Gen Psychiatry 2017 28;16:43. Epub 2017 Nov 28.
    Department of Psychiatry, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokunishi, Shizuoka 4102211 Japan.
    Objectives: Antipsychotics, even atypical ones, can induce hyperprolactinemia. Aripiprazole (APZ), a dopamine D2 partial agonist, has a unique pharmacological profile and few side effects. We investigated the incidence of hyperprolactinemia in patients with schizophrenia treated with APZ and other antipsychotics. Read More

    Sellar plasmacytoma presenting with symptoms of anterior pituitary dysfunction.
    Endocrinol Diabetes Metab Case Rep 2017 24;2017. Epub 2017 Nov 24.
    Endocrinology and Diabetes Department, Garcia de Orta Hospital, Almada, Portugal.
    Sellar plasmacytomas are rare and the differential diagnosis with non-functioning pituitary adenomas might be difficult because of clinical and radiological resemblance. They usually present with neurological signs and intact anterior pituitary function. Some may already have or eventually progress to multiple myeloma. Read More

    Reversal of olanzapine-induced weight gain in a patient with schizophrenia by switching to asenapine: a case report.
    Neuropsychiatr Dis Treat 2017 21;13:2837-2840. Epub 2017 Nov 21.
    Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.
    Aims: Antipsychotics are effective for treating schizophrenia, but atypical antipsychotics can cause several adverse side effects including weight gain, hyperprolactinemia, and extrapyramidal symptoms. Moreover, weight gain increases the risk of metabolic diseases.

    Methods: We treated a case of olanzapine-induced weight gain in a 41-year-old man with schizophrenia by switching his medication from olanzapine to asenapine. Read More

    Endocrine and metabolic assessment in adults with Langerhans cell histiocytosis.
    Eur J Intern Med 2017 Nov 29. Epub 2017 Nov 29.
    U.O. di Endocrinologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Dipartimento di Scienze Cliniche e di Comunità, Università di Milano, Milan, Italy.
    Context: Diabetes insipidus (DI) is one of most common complications of Langerhans cell histiocytosis (LCH) but prevalence of anterior pituitary deficiencies and metabolic alterations have not been clearly defined yet.

    Objectives: Evaluate prevalence of endocrine and metabolic manifestations in a cohort of patients affected by Pulmonary LCH.

    Methods: Observational cross-sectional study on 18 adults (7 M/11 F, 42±12years) studied for complete basal and dynamic endocrine lab tests and glucose metabolism. Read More

    Serum prolactin levels across pregnancy and the establishment of reference intervals.
    Clin Chem Lab Med 2017 Dec 1. Epub 2017 Dec 1.
    .
    Background: Reference intervals (RIs) play key roles in clinical diagnosis, treatment and prognosis. However, RIs for clinical testing tend to be confined to the general population, and RIs for pregnant women are not very comprehensive. In this study, we establish RIs for prolactin (PRL) in healthy pregnant and postpartum women in the Chinese population. Read More

    Macroprolactinemia and Empty Sella Syndrome.
    Pan Afr Med J 2017 14;27:278. Epub 2017 Aug 14.
    Endocrinology and Diabetes Department, University Hospital Farhat Hached Sousse, Tunisia.
    Macroprolactinemia is a polymeric form of prolactin-release, causing mildly symptomatic clinical pictures. The former can be isolated or associated with other causes of hyperprolactinemia. The association with an empty sella syndrome is rare. Read More

    Prolactinoma through the female life cycle.
    Endocrine 2018 Jan 24;59(1):16-29. Epub 2017 Nov 24.
    Multidisciplinary Pituitary and Skull Base Tumor Center, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 419, New York, NY, 10065, USA.
    Prolactinomas are the most common secretory pituitary adenoma. They typically occur in women in the 3rd-6th decade of life and rarely in the pediatric population or after menopause. Most women present with irregular menses and/or infertility. Read More

    Pediatric prolactinoma: initial presentation, treatment, and long-term prognosis.
    Eur J Pediatr 2018 Jan 22;177(1):125-132. Epub 2017 Nov 22.
    Department of Pediatrics and Pediatric Hematology/Oncology, Klinikum Oldenburg AöR, Medical Campus University Oldenburg, Rahel-Straus-Strasse 10, 26133, Oldenburg, Germany.
    Prolactinoma is a rare pituitary adenoma secreting prolactin. Studies on diagnostics, treatment, and prognosis in pediatric prolactinoma patients are rare. We analyzed clinical presentation, response to treatment, and prognosis of 27 pediatric prolactinoma patients (10 m/17 f. Read More

    Impact of macroprolactin on galactorrhea and the rate of patients possibly affected by macroprolactin.
    Endocr J 2017 Nov 22. Epub 2017 Nov 22.
    AMY Information Planning, Tokyo, Japan.
    The clinical influence of macroprolactin (MPRL) is not clearly understood and the rate of patients potentially affected by MPRL is unknown. We investigated the influence of MPRL on the onset of galactorrhea and estimated the rate of patients with a proportion of MPRL fraction that may possibly affect galactorrhea. Data of patients with obstetric or gynecological symptoms who had undergone PRL fractionation testing were retrospectively analyzed. Read More

    Ann Endocrinol (Paris) 2017 Oct;78 Suppl 1:S31-S40
    Université Paris-Sud, Orsay 91400, France; Service d'endocrinologie et des maladies de la reproduction, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, 94275 Le Kremlin-Bicêtre, France; INSERM UMR-1185, faculté de médecine Paris-Sud, 94276 Le Kremlin-Bicêtre, France.
    The endocrine and exocrine functions of the gonads are controlled by the gonadotrope axis, whose master regulator is the hypothalamic decapeptide GnRH. The Kisspeptin/Neurokinin B (Kp/NkB) neuronendocrine system is the main physiologic regulator of GnRH neurons. The Kp/NkB system is currently considered the key mediator for the hypothalamic negative feedback exerted by sex steroids and prolactin, as well as by various metabolic signals. Read More

    Risperidone-Induced Amenorrhea in Floridly Psychotic Female.
    Cureus 2017 Sep 13;9(9):e1683. Epub 2017 Sep 13.
    Behavioral Health, Kings County Hospital Center.
    Despite the high prevalence of hyperprolactinemia in patients receiving antipsychotic medications, its side effects are often neglected. In patients receiving risperidone, the incidence of menstrual abnormalities is relatively small. Our patient was a 44-year-old, Haitian female whose total course of hospitalization was nine months, during most of which she remained floridly psychotic with low cognitive function with waxing and waning symptoms. Read More

    Joint approach based on clinical and imaging features to distinguish non-neoplastic from neoplastic pituitary stalk lesions.
    PLoS One 2017 15;12(11):e0187989. Epub 2017 Nov 15.
    Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
    Purpose: Distinguishing non-neoplastic pituitary stalk lesions (non-NPSLs) from neoplastic pituitary stalk lesions (NPSLs) is a major concern in guiding treatment for a thickened pituitary stalk. Our study aimed to aid provide preoperative diagnostic assistance by combining clinical and magnetic resonance imaging (MRI) findings to distinguish non-NPSLs from NPSLs.

    Materials And Methods: We recruited 158 patients with thickened pituitary stalk lesions visible on MRI. Read More

    Antipsychotic-induced hyperprolactinaemia: case studies and review.
    Postgrad Med J 2017 Nov 9. Epub 2017 Nov 9.
    Consultant Psychiatrist, Adult Mental Health Inpatient Unit, Rotherham Doncaster and South Humber Mental Health NHS Foundation Trust, Doncaster, UK.
    Antipsychotics are a known cause of hyperprolactinaemia and can be associated with significant health issues in short term and long term. The effects vary with gender and age of the individual and can contribute towards non-concordance and hence relapse in mental health of our patients. Clinicians need to educate the patients about this significant side effect of not only antipsychotic medications but other medications causing hyperprolactinaemia commonly prescribed in primary care. Read More

    Antipsychotic polypharmacy in older Australians.
    Int Psychogeriatr 2017 Nov 10:1-8. Epub 2017 Nov 10.
    Quality Use of Medicines and Pharmacy Research Centre,School of Pharmacy and Medical Sciences,Sansom Institute,University of South Australia,Adelaide,South Australia,Australia.
    Background: Antipsychotics are commonly used, and the rate of use is highest, among those aged 65 years or over, where the risk of adverse events is also high. Up to 20% of younger adults use more than one antipsychotic concurrently; however there are few studies on the prevalence of antipsychotic polypharmacy in older people. We aimed to analyze antipsychotic use in elderly Australians, focusing on the prevalence of antipsychotic polypharmacy and the use of medicines to manage adverse events associated with antipsychotics. Read More

    [Valvular heart disease in relation to the treatment of hyperprolactinemia with dopamine agonists].
    Vnitr Lek 2017 ;63(9):561-565
    Adverse effect of dopamine agonists on the heart valves aroused much attention some time ago. Gradually, as data accumulated, the approach to the problem was rationalised and further examinations were only recommended in indicated cases. The paper reviews the current knowledge about the treatment of hyperprolactinemia with dopamine agonists and the risk of valvular disease. Read More

    Three Cases of Hair Loss Analyzed by the Point of View of the Analytical Psychology.
    Int J Trichology 2017 Oct-Dec;9(4):177-180
    Department of Clinical Psychology, Pontifícia universidade Católica de São Paulo, São Paulo, Brazil.
    Psychotrichology is the science, which covers the psychosomatics applied to hair problems, i.e., body-psyche phenomena involving scalp and hair disorders. Read More

    Calcium and Vitamin D Supplementation in Boys with Risperidone-Induced Hyperprolactinemia: A Randomized, Placebo-Controlled Pilot Study.
    J Child Adolesc Psychopharmacol 2017 Nov 7. Epub 2017 Nov 7.
    5 Department of Internal Medicine, The University of Iowa , Iowa City, Iowa.
    Background: The chronic use of antipsychotics has been associated with impaired bone mineralization, partially mediated by hyperprolactinemia. We examined if calcium and vitamin D supplementation promote bone mineral accrual in boys with risperidone-induced hyperprolactinemia.

    Methods: Between February 2009 and November 2013, medically healthy, 5- to 17-year-old boys were enrolled in a 36-week double-blind, placebo-controlled study, examining the skeletal effects of supplementation with 1250 mg calcium carbonate and 400 IU of vitamin D3 in risperidone-induced hyperprolactinemia. Read More

    A phase II study to evaluate the pharmacokinetics, safety, and tolerability of Risperidone ISM multiple intramuscular injections once every 4 weeks in patients with schizophrenia.
    Int Clin Psychopharmacol 2017 Nov 3. Epub 2017 Nov 3.
    aLaboratorios Farmacéuticos ROVI, Madrid, Spain bCBH Health, LLC, Rockville, Maryland, USA.
    This study characterized the pharmacokinetics, safety, and tolerability of Risperidone ISM, a new long-acting intramuscular formulation, for monthly administration without oral supplementation. Patients with schizophrenia received multiple intramuscular injections of 75 mg in the gluteal or deltoid muscle at 28-day intervals. Of the 70 randomized patients, 67 received at least one dose of study medication. Read More

    [Indications for surgical treatment of prolactin-secreting pituitary adenomas].
    Zh Vopr Neirokhir Im N N Burdenko 2017 ;81(5):117-124
    Burdenko Neurosurgical Institute named, Moscow, Russia.
    Prolactinomas account for about 40% of all pituitary adenomas. The main treatment for prolactinomas is undoubtedly therapy with dopamine agonists (DAs). However, prolonged conservative treatment (for many years or even throughout life) that is necessary for permanent control of the disease makes some patients refuse pharmacological treatment for various reasons. Read More

    Presentation, Treatment, and Long-Term Outcome of Intrasellar Chordoma: A Pooled Analysis of Institutional, SEER (Surveillance Epidemiology and End Results), and Published Data.
    World Neurosurg 2018 Jan 20;109:e676-e683. Epub 2017 Oct 20.
    Computational Neurosciences Outcomes Center, Department of Neurosurgery, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    Background: Chordoma that occurs primarily in the sella turcica is rare and presents unique treatment challenges.

    Objective: The purpose of this study was to determine common features, treatment approaches, and survival characteristics of intrasellar chordoma.

    Methods: Institutional databases, the SEER (Surveillance Epidemiology and End Results) database, and PubMed/EMBASE were queried for chordoma with a primarily intrasellar component. Read More

    Males with prolactinoma are at increased risk of incident cardiovascular disease.
    Clin Endocrinol (Oxf) 2018 Jan 8;88(1):71-76. Epub 2017 Nov 8.
    Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
    Objective: To investigate whether the risk of incident cardiovascular disease (CVD) is increased in patients with prolactinoma.

    Design: Population-based, retrospective, open-cohort study using The Health Improvement Network (THIN) database.

    Patients: A total of 2233 patients with prolactinoma and 10 355 matched controls (1:5 ratio) from UK General Practices contributing to THIN were included. Read More

    Optimal timing of dopamine agonist withdrawal in patients with hyperprolactinemia: a systematic review and meta-analysis.
    Endocrine 2018 Jan 17;59(1):50-61. Epub 2017 Oct 17.
    Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.
    Purpose: Dopamine agonists (DAs) are recommended as first-line treatment for patients with hyperprolactinemia. Generally, it is accepted that patients with hyperprolactinemia do not need lifelong medication, but the optimal timing for DA withdrawal has not been determined. The aim of this systematic review and meta-analysis is to assess the impact of DA withdrawal on the clinical outcomes of patients with hyperprolactinemia, and to explore possible factors affecting successful DA withdrawal. Read More

    [Potential clinical application of Kisspeptin in reproductive endocrinology].
    Zhejiang Da Xue Xue Bao Yi Xue Ban 2017 May;46(3):328-333
    Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
    Gonadotropin-releasing hormone (GnRH) plays an important role in the process of reproduction. Studies have shown that a family of peptides Kisspeptin can act on GnRH-related neurons, stimulating the secretion of GnRH, and activating the hypothalamic-pituitary-gonadal axis. Both animal experiments and clinical studies have shown that exogenous administration of Kisspeptin is able to induce physiological GnRH release in healthy individuals and those with endocrine-disorders, which brings great hope for treatment of reproductive endocrine diseases. Read More

    Mining comorbidity patterns using retrospective analysis of big collection of outpatient records.
    Health Inf Sci Syst 2017 Dec 28;5(1). Epub 2017 Sep 28.
    Medical University Sofia, University Specialised Hospital for Active Treatment of Endocrinology, Sofia, Bulgaria.
    Background: Studying comorbidities of disorders is important for detection and prevention. For discovering frequent patterns of diseases we can use retrospective analysis of population data, by filtering events with common properties and similar significance. Most frequent pattern mining methods do not consider contextual information about extracted patterns. Read More

    Improvement in cognitive abilities following cabergoline treatment in patients with a prolactin-secreting pituitary adenoma.
    Int Clin Psychopharmacol 2017 Oct 13. Epub 2017 Oct 13.
    Departments of aMental Health, CIBERSAM bEndocrinology, Corporació Sanitària Parc Taulí, Sabadell, Spain.
    Hyperprolactinaemia may affect sexual and reproductive functioning. However, recent studies suggest that increased prolactin levels may also have negative effects on cognition. We aimed to study whether the reduction in prolactin levels by cabergoline in patients with hyperprolactinaemia is followed by an improvement in cognitive tasks. Read More

    SUBCLINICAL IMPAIRMENT OF LEFT VENTRICULAR LONGITUDINAL FUNCTION IN PATIENTS WITH PROLACTINOMAS.
    Endocr Pract 2017 Dec 11;23(12):1379-1386. Epub 2017 Oct 11.
    Objective: Hyperprolactinemia has been associated with endothelial dysfunction and a wide range of cardiovascular risk factors, thus it can potentially lead to cardiac dysfunction. The present study was designed to interrogate our hypothesis that hyperprolactinemia can contribute to preclinical impaired left ventricular function.

    Methods: Thirty-one prolactinoma patients and 60 healthy volunteers were prospectively recruited. Read More

    Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors.
    Nat Commun 2017 10 2;8(1):763. Epub 2017 Oct 2.
    School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.
    Atypical antipsychotic drugs (APDs) have been hypothesized to show reduced extrapyramidal side effects (EPS) due to their rapid dissociation from the dopamine D2 receptor. However, support for this hypothesis is limited to a relatively small number of observations made across several decades and under different experimental conditions. Here we show that association rates, but not dissociation rates, correlate with EPS. Read More

    Psychiatric Patients with Antipsychotic Drug-Induced Hyperprolactinemia and Menstruation Disorders.
    Biol Pharm Bull 2017 ;40(10):1775-1778
    Division of Pharmacy, Ehime University Hospital.
    Treatment with antipsychotic drugs has been associated with hyperprolactinemia. The same antipsychotic drugs have also been associated with side effects such as menstruation disorders. The aim of this study was to evaluate the prevalence of hyperprolactinemia and menstruation disorders in women undergoing antipsychotic treatment. Read More

    Influence of sulpiride treatment on the level of prolactin and immunoglobulins in the peripheral blood of mares during the postpartum period.
    Acta Vet Hung 2017 09;65(3):417-428
    1 Institute of Veterinary Sciences, University of Agriculture in Kraków, al. Mickiewicza 24-28 , 30-059 Kraków , Poland.
    The aim of this study was to determine the effect of increased levels of prolactin (PRL) on the concentration of immunoglobulins in the blood, colostrum and milk of mares. The study was conducted on 12 mares of the Polish Pony breed (6 in the control and 6 in the experimental group). To induce hyperprolactinaemia in mares of the experimental group, 750 mg sulpiride was administered orally once a day. Read More

    Morbidity and mortality in patients with hyperprolactinaemia: the PROLEARS study.
    Endocr Connect 2017 Nov;6(8):580-588
    Division of Molecular and Clinical MedicineSchool of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
    Purpose: High serum prolactin concentrations have been associated with adverse health outcomes in some but not all studies. This study aimed to examine the morbidity and all-cause mortality associated with hyperprolactinaemia.

    Methods: A population-based matched cohort study in Tayside (Scotland, UK) from 1988 to 2014 was performed. Read More

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