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    [Preoperative and postoperative endocrine disorders associated with pituitary stalk injuries caused by suprasellar growing tumors].
    Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(1):13-21
    Burdenko Neurosurgery Institute, 4-ya Tverskaya-Yamskaya Str., 16, Moscow, Russia, 125047.
    The pituitary stalk (PS) is a relatively thin bundle connecting the hypophyseal stalk to the pituitary gland; it consists of both axons of the hypothalamic nuclei (terminating in the neurohypophysis) and the system of portal vessels. Compression of the PS by a space-occupying lesion or its transection (forced or intended) during surgery may lead to the development of endocrine disorders: hypopituitarism, diabetes insipidus, and hyperprolactinemia. The modern literature lacks studies evaluating the severity of endocrine disorders depending on the PS condition before and after surgery. Read More

    Abnormal Uterine Bleeding In Adolescents.
    J Clin Res Pediatr Endocrinol 2018 Feb 28. Epub 2018 Feb 28.
    Abnormal uterine bleeding (AUB) is the major gynecologic complaint of adolescents admitting to hospital. Heavy menstrual bleeding (HMB) is the most common clinical presentation of AUB. Anovulatory cycles owing to immature hypothalamic-pituitary-ovarian axis is the leading etiology of HMB and there is an accompanying bleeding disorder in almost %20 of patients with HMB. Read More

    Idiopathic Granulomatous Mastitis: Manifestations at Multimodality Imaging and Pitfalls.
    Radiographics 2018 Mar-Apr;38(2):330-356
    From the Departments of Radiology (C.W.P.T., J.E.N., H.A., K.A.K., N.C.D.) and Pathology (D.D.M.), University of Texas Health at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229; and Department of Radiology, Bryn Mawr Hospital, Bryn Mawr, Pa (C.J.Q.).
    Idiopathic granulomatous mastitis (IGM) is a rare benign inflammatory breast entity characterized by lobulocentric granulomas. IGM has a persistent or recurrent disease course and affects parous premenopausal women with a history of lactation. It has also been associated with hyperprolactinemia. Read More

    Treatment escape reduces the effectiveness of cabergoline during long-term treatment of acromegaly in monotherapy or in association with first-generation somatostatin receptor ligands.
    Clin Endocrinol (Oxf) 2018 Mar 9. Epub 2018 Mar 9.
    Neuroendocrinology Research Center / Endocrinology Division - Medical School and Hospital Universitário Clementino Fraga Filho - Universidade Federal do, Rio de Janeiro, Rio de Janeiro, Brazil.
    Background: Few studies evaluated the use of cabergoline (CAB) for acromegaly treatment in monotherapy or in combination with first-generation somatostatin receptor ligands (SRLs).

    Aim: Evaluate the efficacy, predictors of response and safety of CAB treatment in acromegaly both in monotherapy and in combination with SRLs.

    Methods: We retrospectively collected demographic, biochemical, tumor and treatment data. Read More

    Efficacy, Tolerability, and Safety of Blonanserin in Schizophrenia: An Updated and Extended Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Pharmacopsychiatry 2018 Mar 7. Epub 2018 Mar 7.
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
    Introduction: We conducted an updated systematic review and meta-analysis of randomized controlled trials (RCTs) comparing blonanserin with other antipsychotics (amisulpride, aripiprazole, haloperidol, paliperidone, and risperidone).

    Methods: Weighted mean difference (WMD), risk ratio, and number needed to harm (NNH) with 95% confidence intervals (95% CIs) were calculated using random-effects model.

    Results: Ten RCTs (n1521) were included in this study. Read More

    Prolactin and Autoimmunity.
    Front Immunol 2018 12;9:73. Epub 2018 Feb 12.
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
    The great asymmetry of autoimmune diseases between genders represents one of the most enigmatic observations among the mosaic of autoimmunity. Sex hormones are believed to play a crucial role on this dimorphism. The higher prevalence of autoimmunity among women at childbearing ages, disease onset/relapses during pregnancy, and post-partum are some of the arguments that support this hypothesis. Read More

    Effects of Risperidone and Aripiprazole on Serum Levels of Prolactin, Testosterone and Estradiol in Female Patients with Schizophrenia.
    Drug Res (Stuttg) 2018 Feb 26. Epub 2018 Feb 26.
    The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
    Objective: To evaluate the effects of treatment with risperidone and aripiprazole on serum prolactin, testosterone and estradiol levels in female patients with schizophrenia in China.

    Methods: In the retrospective study, Data were collected and included prolactin, testosterone and estradiol levels of 30 female patients with risperidone monotherapy. In the prospective study, Another 30 female schizophrenic patients were randomized to receive risperidone or adjunctive aripiprazole for six weeks. Read More

    The effect of bromocriptine treatment on sexual functioning and depressive symptoms in women with mild hyperprolactinemia.
    Pharmacol Rep 2018 Feb 20;70(2):227-232. Epub 2018 Feb 20.
    Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.
    Background: Elevated prolactin levels are associated with sexual dysfunction in women. No previous study has investigated the effect of dopamine agonists on sexual functioning in women.

    Methods: The study enrolled 30 young women with mild hyperprolactinemia (serum prolactin levels in the range between 25 and 50 ng/mL), 15 of whom were later treated with bromocriptine (5-10 mg daily), as well as 14 age- and weight-matched healthy women. Read More

    Cabergoline-Induced Pneumocephalus Following Treatment for Giant Invasive Macroprolactinoma Presenting With Spontaneous Cerebrospinal Fluid Rhinorrhea.
    Clin Med Insights Endocrinol Diabetes 2018 13;11:1179551418758640. Epub 2018 Feb 13.
    Obesity, Endocrine, and Metabolism Center, King Fahad Medical City, Riyadh, Saudi Arabia.
    Cerebrospinal fluid (CSF) rhinorrhea is rarely reported as the first presenting feature of giant invasive macroprolactinomas. Cerebrospinal fluid rhinorrhea is usually reported as a complication of trauma, neurosurgical, and skull-based procedures (such as pituitary surgery or radiations), and less frequently after medical treatment with dopamine agonists (DAs) for macroprolactinomas. This phenomenon results from fistula creation that communicates between the subarachnoid space and the nasal cavity. Read More

    Clinical Features and Response to Treatment of Prolactinomas in Children and Adolescents: A Retrospective Single-Centre Analysis and Review of the Literature.
    Horm Res Paediatr 2018 Feb 16. Epub 2018 Feb 16.
    Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics, University Hospital Heidelberg, Heidelberg, Germany.
    Background: Paediatric prolactinomas are rare. The aim of this study was to investigate the clinical features and outcome of paediatric patients with prolactinomas.

    Methods: In this single-centre retrospective analysis, clinical, biochemical, and radiological features of all paediatric patients with pituitary adenomas diagnosed between 2000 and 2016 were evaluated. Read More

    Cognitive Function and Serum Hormone Levels Are Associated with Gray Matter Volume Decline in Female Patients with Prolactinomas.
    Front Neurol 2017 29;8:742. Epub 2018 Jan 29.
    Department of Neurosurgery, Wuhan General Hospital, Southern Medical University, Guangzhou, China.
    Background And Objective: Cognitive impairments have been reported in patients with hyperprolactinemia; however, there is a lack of knowledge of brain structure alterations relevant to hyperprolactinemia in prolactinomas. Thus, we aimed to identify changes in brain structure in prolactinomas and to determine whether these changes are related to cognitive performance and clinical characteristics.

    Methods: Participants were 32 female patients with prolactinomas and 26 healthy controls (HC) matched for age, sex, education, and handedness. Read More

    Mucuna pruriens (L.) DC chemo sensitize human breast cancer cells via downregulation of prolactin-mediated JAK2/STAT5A signaling.
    J Ethnopharmacol 2018 May 7;217:23-35. Epub 2018 Feb 7.
    Department of Pharmacognosy and Phytochemistry, B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Ahmedabad, Gujarat, India. Electronic address:
    Ethnopharmacological Relevance: Mucuna pruriens (L.) DC (MP) is an ancient Indian medicinal plant traditionally used to treat Parkinson's disease. L-Dopa (LD), precursor of dopamine is abundantly found in the seeds of MP. Read More

    Venous Thromboembolism During Treatment with Antipsychotics: A Review of Current Evidence.
    CNS Drugs 2018 Jan;32(1):47-64
    Futurum, Region Jönköping County, Department of Medical and Health Sciences, Linköping University, Sweden.
    This article summarises the current evidence on the risk of venous thromboembolism (VTE) with the use of antipsychotics. An increasing number of observational studies indicate an elevated risk of VTE in antipsychotic drug users. Although the use of certain antipsychotics has been associated with VTE, current data can neither conclusively verify differences in occurrence rates of VTE between first- and second-generation antipsychotics or between individual compounds, nor identify which antipsychotic drugs have the lowest risk of VTE. Read More

    Meta regression: Relationship between antipsychotic receptor binding profiles and side-effects.
    Prog Neuropsychopharmacol Biol Psychiatry 2018 Feb 1. Epub 2018 Feb 1.
    Yale Child Study Center, Department of Psychiatry, Yale University, New Haven, CT, United States. Electronic address:
    Our objective was to examine the association between antipsychotic receptor binding profiles and the magnitude of common side-effects. We used regression analysis to examine the association between the receptor binding affinities of antipsychotic agents (log Ki) and degree of specific antipsychotic side-effects. Data on magnitude of weight gain, prolactin increase and QTc prolongation (in Standardized Mean Difference) and risk of sedation and extrapyramidal symptoms (in Odds Ratio) between individual antipsychotic medications as compared to placebo was based on a recent network meta-analysis examining the treatment of schizophrenia. Read More

    Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects.
    Eur J Med Chem 2018 Feb 3;145:790-804. Epub 2018 Jan 3.
    Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 31-343 Kraków, Poland. Electronic address:
    Currently used antipsychotics are characterized by multireceptor mode of action. While antagonism of dopamine Dreceptors is responsible for the alleviation of "positive" symptoms of schizophrenia and the effects at other, particularly serotonergic receptors are necessary for their additional therapeutic effects, there is no consensus regarding an "ideal" target engagement. Here, a detailed SAR analysis in a series of 45 novel azinesulfonamides of cyclic amine derivatives, involving the aryl-piperazine/piperidine pharmacophore, central alicyclic amine and azinesulfonamide groups has led to the selection of (S)-4-((2-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)isoquinoline (62). Read More

    Female gonadal functions and ovarian reserve in patients with acromegaly: experience from a single tertiary center.
    Endocrine 2018 Apr 5;60(1):167-174. Epub 2018 Feb 5.
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
    Purpose: To evaluate the gonadal functions and related factors in female patients with acromegaly at the time of diagnosis, the course of gonadal dysfunctions and pregnancies during the follow-up period, and the investigation of ovarian reserve with serum anti-Mullerian hormone (AMH) levels in patients with reproductive age.

    Methods: Patients who were not menopausal at the time of acromegaly diagnosis (n = 47) were included in this study. Baseline gonadal status was evaluated retrospectively. Read More

    Extended Endoscopic Endonasal Approach for Suprasellar Craniopharyngioma.
    J Neurol Surg B Skull Base 2018 Feb 18;79(2):S196-S198. Epub 2018 Jan 18.
    Department of Otorhinolaryngology, University of Insubria - Ospedale di Circolo Fondazione Macchi, Varese, Italy.
     We illustrate a suprasellar craniopharyngiomas treated with an extended endoscopic endonasal approach (EEEA). Case report of a 43-year-old male affected by cerebral lesion located in suprasellar region involving the third ventricle and compressing the neurovascular structures, causing an anterosuperior dislocation of the chiasma. There is a complete disruption of the pituitary stalk that can explain the clinical finding of partial anterior hypopituitarism and hyperprolactinemia. Read More

    Impact of Triclosan on Female Reproduction through Reducing Thyroid Hormones to Suppress Hypothalamic Kisspeptin Neurons in Mice.
    Front Mol Neurosci 2018 19;11. Epub 2018 Jan 19.
    State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, China.
    Triclosan (TCS), a broad-spectrum antimicrobial agent, is widely used in clinical settings and various personal care products. The aim of this study was to evaluate the influence of TCS on reproductive endocrine and function. Here, we show that the exposure of adult female mice to 10 or 100 mg/kg/day TCS caused prolongation of diestrus, and decreases in antral follicles and corpora lutea within 2 weeks. Read More

    Add-on Aripiprazole for Atypical Antipsychotic-induced, Clinically Significant Hyperprolactinemia.
    Indian J Psychol Med 2018 Jan-Feb;40(1):38-40
    Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
    Background: Antipsychotic treatment-induced hyperprolactinemia is a highly distressing and disabling side effect for patients. The use of add-on aripiprazole has been identified as a possible treatment strategy in this situation. However, data on prolactin changes with add-on aripiprazole in a real-world naturalistic clinical setting from India are sparse. Read More

    Role of prolactin/adenoma maximum diameter and prolactin/adenoma volume in the differential diagnosis of prolactinomas and other types of pituitary adenomas.
    Oncol Lett 2018 Feb 21;15(2):2010-2016. Epub 2017 Nov 21.
    Department of Neurosurgery, Fuzhou General Hospital, Fujian Medical University, Fuzhou, Fujian 350025, P.R. China.
    The present study aimed to investigate the function of the prolactin/adenoma maximum diameter (PRL/MD) and the prolactin/adenoma volume (PRL/V) in the differential diagnosis of prolactinomas and other types of pituitary adenomas. A total of 118 patients with pituitary adenoma, hyperprolactinemia and a plasma PRL <250 µg/l were enrolled. Clinical data from these patients were retrospectively analyzed. Read More

    Frequency of Macroprolactin in Hyperprolactinemia.
    J Coll Physicians Surg Pak 2018 Feb;28(2):93-97
    Department of Pathology and Laboratory Medicine, The Aga Khan University, Karachi.
    Objective: To determine the frequency of Macroprolactin (MaPRL) in patients with increased total prolactin and its clinical and financial impact.

    Study Design: Cross-sectional study.

    Place And Duration Of Study: Section of Clinical Chemistry, Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi, from March to May 2015. Read More

    [Cerebrospinal fluid rhinorrhea in primary treatment of large and giant prolactinomas with dopamine agonists].
    Zh Vopr Neirokhir Im N N Burdenko 2017 ;81(6):32-39
    Burdenko Neurosurgical Institute, Moscow, Russia, 125047.
    At present, pharmacological therapy of prolactinomas with dopamine agonists (DAs) is considered the treatment of choice. In most cases, giant prolactinomas respond to treatment with dopamine agonists and decrease in size during the first months of the treatment. One of the rare but dangerous complications of conservative treatment of prolactinomas with invasive growth is cerebrospinal fluid rhinorrhea. Read More

    Endocrine Abnormalities in Adolescents with Menstrual Disorders.
    J Obstet Gynaecol India 2018 Feb 17;68(1):58-64. Epub 2017 Jul 17.
    4Department of Preventive and Social Medicine, JIPMER, Puducherry, 605006 India.
    Purpose: To look for endocrine abnormalities like thyroid disorders, hyperprolactinemia, hyperandrogenism and PCOS among adolescents with menstrual disorders and to compare the above endocrine status with those without menstrual disorders.

    Methods: This was a case-control study carried out in adolescent girls aged 10-19 years in gynecology outpatient department of a tertiary care hospital. Sample of venous blood (5 ml) was taken for hormonal studies as clinically indicated-thyroid function test, serum prolactin, total testosterone, which were analyzed by chemiluminescence system. Read More

    The prolactin-release inhibitor paeoniflorin suppresses proliferation and induces apoptosis in prolactinoma cells via the mitochondria-dependent pathway.
    J Cell Biochem 2018 Feb 1. Epub 2018 Feb 1.
    Endocrinology and Metabolism Group, Sydney Institute of Health Sciences/Sydney Institute of Traditional Chinese Medicine, New South Wales, Australia.
    Prolactinomas are the most prevalent functional pituitary adenomas that cause chronic pathological hyperprolactinemia. Prolactin is known to promote cell growth and inhibit apoptosis in cells. Paeoniflorin is the principal component of radix Paeoniae alba (the main ingredient in some traditional herbal formulas clinically used for hyperprolactinemia-associated disorders). Read More

    Primary meningeal melanocytoma in sellar region, simulating a nonfunctioning pituitary adenoma; a case report and literature review.
    World Neurosurg 2018 Jan 27. Epub 2018 Jan 27.
    Department of Neurosurgery, the First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital). Electronic address:
    Background: and Importance Primary meningeal melanocytoma (PMM) is a benign lesion in the central nervous system derived from leptomeningeal melanocytes, most commonly growing in the posterior fossa and cervical spinal cord. The primary sellar melanocytoma is an exceptionally rare tumor. The authors reported the ninth published case of a sellar primary meningeal melanocytoma (SPMM). Read More

    Neuropsychiatric and metabolic aspects of dopaminergic therapy: perspectives from an endocrinologist and a psychiatrist.
    Endocr Connect 2018 Feb 29;7(2):R88-R94. Epub 2018 Jan 29.
    Max Planck Institute of PsychiatryDepartment of Internal Medicine, Endocrinology and Clinical Chemistry, Munich, Germany
    The dopaminergic treatment represents the primary treatment in prolactinomas, which are the most common pituitary adenomas and account for about 40% of all pituitary tumours with an annual incidence of six to ten cases per million population. The dopaminergic treatment includes ergot and non-ergot derivatives with high affinity for the dopamine receptors D1 or/and D2. Through the activation of the dopaminergic pathway on pituitary lactotrophs, the dopamine agonists inhibit the prolactin synthesis and secretion, therefore normalizing the prolactin levels and restoring eugonadism, but they also lead to tumour shrinkage. Read More

    Epidemiology, clinical presentation and diagnosis of non-functioning pituitary adenomas.
    Pituitary 2018 Apr;21(2):111-118
    Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, UK.
    Purpose: Non-functioning pituitary adenomas (NFPAs) are benign pituitary neoplasms that do not cause a hormonal hypersecretory syndrome. An improved understanding of their epidemiology, clinical presentation and diagnosis is needed.

    Method: A literature review was performed using Pubmed to identify research reports and clinical case series on NFPAs. Read More

    Pituitary xanthogranulomas: clinical features, radiological appearances and post-operative outcomes.
    Pituitary 2018 Jan 23. Epub 2018 Jan 23.
    B4 Office, Department of Neurosurgery, University Hospital of Wales, Cardiff, CF 14 4XW, UK.
    Background: Xanthogranulomas are inflammatory masses most commonly found at peripheral sites such as the skin. Sellar and parasellar xanthogranulomas are rare and present a diagnostic challenge as they are difficult to differentiate from other sellar lesions such as craniopharyngiomas and Rathke's cleft cysts pre-operatively. Their radiological imaging features are yet to be clearly defined, and clinical outcomes after surgery are also uncertain. Read More

    The impact of severe mental disorders and psychotropic medications on sexual health and its implications for clinical management.
    World Psychiatry 2018 Feb;17(1):3-11
    Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
    Sexual dysfunction often accompanies severe psychiatric illness and can be due to both the mental disorder itself and the use of psychotropic treatments. Many sexual symptoms resolve as the mental state improves, but treatment-related sexual adverse events tend to persist over time, and are unfortunately under-recognized by clinicians and scarcely investigated in clinical trials. Treatment-emergent sexual dysfunction adversely affects quality of life and may contribute to reduce treatment adherence. Read More

    [Clinical features and prognosis of 18 cases of primary lymphocytic hypophysitis].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(2):102-108
    Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
    To analyze clinical features, prognosis and treatment of lymphocytic hypophysitis (LYH).The clinical data, treatments and outcomes of 18 cases diagnosed as LYH at Chinese PLA General Hospital between January 2001 and July 2017 was respectively reviewed.Eighteen patients with histology-proven LYH (13 females and 5 males ) were identified. Read More

    Prevalence and risk factors of hyperprolactinemia among patients with various psychiatric diagnoses and medications.
    Int J Psychiatry Clin Pract 2018 Jan 15:1-8. Epub 2018 Jan 15.
    g Mental Health Hospital , Abha , Saudi Arabia.
    Objectives: Hyperprolactinemia is a common adverse event associated with psychotropic medications (mainly antipsychotics) used in the management of schizophrenia and bipolar disorders. The aim of this study was to estimate the prevalence of hyperprolactinemia in psychiatric patients and to evaluate its association with various psychiatric diagnoses and the use of various psychotropic medications.

    Methods: A cross-sectional observational study was conducted between July 2012 and June 2014. Read More

    From Bench to Bedside: Translating the Prolactin/Vasoinhibin Axis.
    Front Endocrinol (Lausanne) 2017 11;8:342. Epub 2017 Dec 11.
    Institute for Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Nuremberg General Hospital, Paracelsus Medical University, Nuremberg, Germany.
    The prolactin/vasoinhibin axis defines an endocrine system, in which prolactin (PRL) and vasoinhibins regulate blood vessel growth and function, the secretion of other hormones, inflammatory and immune processes, coagulation, and behavior. The core element of the PRL/vasoinhibin axis is the generation of vasoinhibins, which consists in the proteolytic cleavage of their precursor molecule PRL. Vasoinhibins can interact with multiple different partners to mediate their effects in various tissues and anatomical compartments, indicating their pleiotropic nature. Read More

    Effect of Peony-Glycyrrhiza Decoction on Amisulpride-Induced Hyperprolactinemia in Women with Schizophrenia: A Preliminary Study.
    Evid Based Complement Alternat Med 2017 26;2017:7901670. Epub 2017 Nov 26.
    Department of Psychiatry, Brains Hospital of Hunan Province, Changsha, China.
    Objective: The aim of this study is to observe the effect of Peony-Glycyrrhiza Decoction (PGD) on hyperprolactinemia in women with schizophrenia induced by Amisulpride.

    Material And Methods: A total of 41 female schizophrenia patients receiving Amisulpride were randomly divided into placebo (= 20) and PGD groups (= 21). Maintaining the original Amisulpride dose, the two groups were given placebo and PGD, respectively. Read More

    Prescribing Trends of Atypical Antipsychotic Drugs in an Outpatient Unit of a Child and Adolescent Clinic in Turkey.
    Clin Neuropharmacol 2018 Jan/Feb;41(1):23-27
    Objective: Use of antipsychotic agents in the management of various psychopathologies in Child and Adolescent Psychiatric practice is gradually increasing. This study aimed to evaluate the sociodemographic and clinical features of children and adolescents who applied to an outpatient clinic of child and adolescent psychiatry department in Turkey and were prescribed atypical antipsychotics.

    Method: Patients with prescription codes of ATC N05A (except N05AN lithium) were accepted to denote those with atypical antipsychotic treatment. Read More

    Quetiapine reverses paclitaxel-induced neuropathic pain in mice: Role of alpha2- adrenergic receptors.
    Iran J Basic Med Sci 2017 Nov;20(11):1182-1188
    Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.
    Objectives: Paclitaxel-induced peripheral neuropathy is a common adverse effect of cancer chemo -therapy. This neuropathy has a profound impact on quality of life and patient's survival. Preventing and treating paclitaxel-induced peripheral neuropathy is a major concern. Read More

    Broad clinical spectrum and diverse outcomes of prolactinoma with pediatric onset: medication-resistant and recurrent cases.
    Endocr J 2017 Dec 27. Epub 2017 Dec 27.
    Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
    Prolactinoma is a benign tumor of the pituitary gland that rarely occurs in children and adolescents; thus, the clinical spectrum and long-term prognosis in these patients remain unknown. This study was performed to investigate the long-term outcomes of medical treatment and the prognostic factors for remission and relapse in children and adolescents with prolactinoma. Three male subjects and four female subjects between the ages of 7- and 17-years-old were included in this study. Read More

    Higher TSH Levels Within the Normal Range Are Associated With Unexplained Infertility.
    J Clin Endocrinol Metab 2018 Feb;103(2):632-639
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts.
    Context: Unexplained infertility (UI), defined as the inability to conceive after 12 months of unprotected intercourse with no diagnosed cause, affects 10% to 30% of infertile couples. An improved understanding of the mechanisms underlying UI could lead to less invasive and less costly treatment strategies. Abnormalities in thyroid function and hyperprolactinemia are well-known causes of infertility, but whether thyrotropin (TSH) and prolactin levels within the normal range are associated with UI is unknown. Read More

    Prolactinomas: how to handle prior to and during pregnancy?
    Minerva Endocrinol 2017 Dec 21. Epub 2017 Dec 21.
    Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo, Brazil -
    Prolactinomas are the most common cause of pathological hyperprolactinemia, leading to central hypogonadism and, therefore, a frequent etiology of infertility. Treatment, usually with dopamine agonist (DA), can reverse hyperprolactinemia and hypogonadism, allowing pregnancy in the majority of cases. Bromocriptine is still the DA of choice for such purpose. Read More

    Cabergoline Tapering Is Almost Always Successful in Patients With Macroprolactinomas.
    J Endocr Soc 2017 Mar 16;1(3):221-230. Epub 2017 Feb 16.
    Service d'Endocrinologie et des Maladies de la Reproduction and Centre de Référence des Maladies Endocriniennes Rares de la Croissance, and.
    Context: Cabergoline (CAB) is very effective in the treatment of macroprolactinomas, but there are few data on the CAB dose necessary to achieve and maintain normal prolactin (PRL) levels.

    Design And Patients: We retrospectively studied 260 patients. CAB was introduced at a mean dose of 0. Read More

    Hypothalamic-Pituitary-Ovarian Axis Reactivation by Kisspeptin-10 in Hyperprolactinemic Women With Chronic Amenorrhea.
    J Endocr Soc 2017 Nov 16;1(11):1362-1371. Epub 2017 Oct 16.
    Reproductive Endocrinology Department, Le Kremlin-Bicêtre, F-94275, France.
    Context: Hyperprolactinemia-induced hypogonadotropic amenorrhea (hPRL-HA) is a major cause of hypothalamic gonadotrophin-releasing hormone (GnRH) deficiency in women. In hyperprolactinemic mice, we previously demonstrated that hypothalamic kisspeptin (Kp) expression was diminished and that Kp administration restored hypothalamic GnRH release, gonadotropin secretion, and ovarian cyclicity, suggesting that Kp neurons could also play a role in hPRL-HA.

    Objective: To study the effect of Kp-10 on the gonadotropic-ovarian axis in women with hPRL-HA. Read More

    [Analysis of clinical features of 23 patients with POEMS syndrome].
    Beijing Da Xue Xue Bao Yi Xue Ban 2017 Dec;49(6):985-989
    Department of Endocrinology, Peking University People's Hospital, Beijing 100044, China.
    Objective: To describe the endocrine abnormalities in patients with POEMS syndrome in order to identify more patients with POEMS syndrome among those who have endocrine dysfunctions.

    Methods: We searched the inpatient medical record system of Peking University People's Hospital with "POEMS syndrome". Finally the data from 23 patients were analyzed. Read More

    Mass effect: a plethora of symptoms caused by an otherwise benign transitional pituitary meningioma. Case report.
    Rom J Morphol Embryol 2017 ;58(3):983-988
    Department of Plastic Surgery and Reconstructive Microsurgery, Emergency Clinical Hospital of Bucharest, Romania;
    Meningiomas are among the most commonly encountered tumors of the central nervous system, being more frequent in females. We present the case of a dyslipidemic male patient, previously diagnosed with coronary artery disease for which he previously underwent percutaneous coronary intervention with the placement of two bare metal stents on the left anterior descending artery. He was presented to the emergency department for atypical angina and a seven-day history of dizziness when switching from clino- to orthostatism, reduced visual acuity, diplopia and vomiting. Read More

    Impact of Kidney Transplantation on Reproductive Hormone Levels in Males: A Longitudinal Study.
    Nephron 2018 14;138(3):192-201. Epub 2017 Dec 14.
    Department of Nephrology, Lund University, Skåne University Hospital, Malmö, Sweden.
    Background/aims: Male patients with end-stage renal disease suffer from sexual disturbances and infertility. Disturbances in the hypothalamic-pituitary-gonadal axis are one of the causes of this. Decreased testosterone synthesis in Leydig cells of the testes and hyperprolactinemia are common. Read More

    Laboratory and clinical significance of macroprolactinemia in women with hyperprolactinemia.
    Taiwan J Obstet Gynecol 2017 Dec;56(6):719-724
    Department of Obstetrics and Gynecology, Cantonal Hospital Zenica, Zenica, Bosnia and Herzegovina.
    The role of macroprolactinemia in women with hyperprolactinemia is currently controversial and can lead to clinical dilemmas, depending upon the origin of macroprolactin, the presence of hyperprolactinemic symptoms and monomeric prolactin (PRL) levels. Macroprolactinemia is mostly considered an extrapituitary phenomenon of mild and asymptomatic hyperprolactinemia associated with normal concentrations of monomeric PRL and a predominance of macroprolactin confined to the vascular system, which is biologically inactive. Patients can therefore be reassured that macroprolactinemia should be considered a benign clinical condition, resistant to antiprolactinemic drugs, and that no diagnostic investigations or prolonged follow-up should be necessary. Read More

    Sex differences in the relationship between prolactin levels and impaired processing speed in early psychosis.
    Aust N Z J Psychiatry 2017 Dec 1:4867417744254. Epub 2017 Dec 1.
    1 Parc Taulí Hospital Universitari, I3PT, Universitat Autònoma de Barcelona, CIBERSAM, Sabadell, Spain.
    Introduction: Hyperprolactinaemia is commonly observed in people with psychotic disorders due to D2 receptor blockade by antipsychotic drugs, although it may also exist in drug-naïve patients with first-episode psychosis. Recent studies suggest that hyperprolactinaemia may have a negative impact on cognitive function in people with early psychosis. We aimed to explore whether there are sex differences in the association between prolactin levels and cognitive performance in early psychosis patients. Read More

    Serum prolactin levels and sexual dysfunction in patients with schizophrenia treated with antipsychotics: comparison between aripiprazole and other atypical antipsychotics.
    Ann Gen Psychiatry 2017 28;16:43. Epub 2017 Nov 28.
    Department of Psychiatry, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokunishi, Shizuoka 4102211 Japan.
    Objectives: Antipsychotics, even atypical ones, can induce hyperprolactinemia. Aripiprazole (APZ), a dopamine D2 partial agonist, has a unique pharmacological profile and few side effects. We investigated the incidence of hyperprolactinemia in patients with schizophrenia treated with APZ and other antipsychotics. Read More

    Sellar plasmacytoma presenting with symptoms of anterior pituitary dysfunction.
    Endocrinol Diabetes Metab Case Rep 2017 24;2017. Epub 2017 Nov 24.
    Endocrinology and Diabetes Department, Garcia de Orta Hospital, Almada, Portugal.
    Sellar plasmacytomas are rare and the differential diagnosis with non-functioning pituitary adenomas might be difficult because of clinical and radiological resemblance. They usually present with neurological signs and intact anterior pituitary function. Some may already have or eventually progress to multiple myeloma. Read More

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