6,794 results match your criteria Hyperprolactinemia


Prolactin induces IL-2 associated TRAIL expression on natural killer cells from chronic hepatitis C patients in vivo and in vitro.

Endocr Metab Immune Disord Drug Targets 2018 Dec 6. Epub 2018 Dec 6.

Laboratorio de Hígado, Páncreas y Motilidad (HIPAM) - Unidad de Investigación en Medicina Experimental, Facultad de Medicina, UNAM. Mexico.

Background: Natural killer cells (NKC) are a major component of innate immune response to HCV, mediating their effects through TRAIL and IFN-γ. However, their function is diminished in chronic HCV patients (HCVp). Prolactin is an immunomodulatory hormone capable of activating NKC. Read More

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December 2018

Giant prolactinoma, germline BRCA1 mutation, and depression: a case report.

J Med Case Rep 2018 Dec 6;12(1):360. Epub 2018 Dec 6.

Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, E.P.E., Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.

Background: Giant prolactinomas are very rare pituitary tumors that may exhibit an aggressive behavior and present with a life-threatening condition.

Case Presentation: A 25-year-old white woman was admitted to our hospital with a headache, psychomotor retardation, reduced vision, and loss of autonomy in daily activities. Her past medical history was significant for having oligomenorrhea and a depressive syndrome since her mother's death. Read More

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December 2018
1 Read

ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS.

Front Endocrinol (Lausanne) 2018 15;9:669. Epub 2018 Nov 15.

Center for Reproductive Medicine, School of Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China.

Ovulatory disorder is common in patients with hyperprolactinemia or polycystic ovary syndrome (PCOS). Previous studies have shown that ATF4 plays critical role in apoptosis and glucose homeostasis, but its role in regulating reproductive function was not explored. The present study investigated the role of ATF4 in ovarian ovulatory function. Read More

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November 2018

Bromocriptine-responsive supersellar germinoma with the expression of dopamine receptors: A case report.

Clin Neurol Neurosurg 2018 Nov 10;176:15-18. Epub 2018 Nov 10.

Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197# Ruijin Er Road, Shanghai, 200025, China. Electronic address:

Background: Germinomas are sensitive to radiotherapy and chemotherapy. However, there has been no report involving in the potential therapeutic effect of dopamine agonists (DAs) such as bromocriptine on germinomas.

Case Description: A 20-year-old female was presented with bitemporal visual disturbance and amenorrhea. Read More

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November 2018
3 Reads

Different effects of fenofibrate on cardiometabolic risk factors in young women with and without hyperprolactinemia.

Pharmacol Rep 2018 Sep 6;71(1):61-66. Epub 2018 Sep 6.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Background: Elevated prolactin levels are associated with increased cardiometabolic risk. No previous study has compared the effect of hypolipidemic therapy on plasma levels of lipids and other cardiometabolic risk factors in patients with and without hyperprolactinemia.

Methods: The study included three age-, weight-, blood pressure- and lipid-matched groups of premenopausal women: 18 women with untreated hyperprolactinemia, 19 women with bromocriptine-treated hyperprolactinemia and 20 drug-naïve women with normal prolactin levels. Read More

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September 2018
2 Reads

Suppression of prolactin secretion partially explains the anti-diabetic effect of bromocriptine in ob/ob mice.

Endocrinology 2018 Nov 20. Epub 2018 Nov 20.

Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.

Previous studies have shown that bromocriptine mesylate (Bromo) lowers blood glucose levels in adults with type 2 diabetes mellitus. However, the mechanism of action of the anti-diabetic effects of Bromo is unclear. As a dopamine receptor agonist, Bromo can alter brain dopamine activity affecting glucose control. Read More

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November 2018
4 Reads

Galactocele of adult male breast: A cytopathologist's perspective.

Diagn Cytopathol 2018 Nov 21. Epub 2018 Nov 21.

Dr. Datta's Clinic, Chandannagar, Hooghly, India.

Galactocele, although a common cytological diagnosis in females, is not previously reported as a cause of breast enlargement in adult males. Hyperprolactinemia is the principal cause of galactocele in male breast. Besides drug induced hyperprolactinemia, other anatomical lesions of hypothalamo-pituitary region and different medical conditions like cirrhosis and chronic kidney disease are to be considered along with a full evaluation of features revealing hypogonadism in case of galactocele. Read More

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November 2018
1 Read

Galactocele After Aesthetic Breast Augmentation with Silicone Implants: An Uncommon Presentation.

Aesthetic Plast Surg 2018 Nov 19. Epub 2018 Nov 19.

Unit of Plastic Surgery, Sapienza University of Rome, Rome, Italy.

Background: Breast augmentation is one of the most frequently performed esthetic operations. Galactorrhea and galactocele formation are both very rare complications. The real cause still remains unknown, but various risk factors have been well reported in the literature. Read More

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November 2018
11 Reads

Dopamine D receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia.

Neuropsychopharmacology 2018 Oct 26. Epub 2018 Oct 26.

Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Dopamine D receptor occupancy (DRO) is a key feature of all currently approved antipsychotic medications. However, antipsychotic efficacy associated with high DRO is often limited by side effects such as motor disturbances and hyperprolactinemia. Lumateperone (ITI-007) is a first-in-class selective and simultaneous modulator of serotonin, dopamine and glutamate in development for the treatment of schizophrenia and other disorders. Read More

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October 2018
2 Reads

CHANGE OF CENTRAL AND PERIPHERAL VISION IN PATIENT WITH SYMPTOMATIC CYST OF RATHKE'S CLEFT FOLLOWING TRANSSPHENOIDAL RESECTION.

Cesk Slov Oftalmol 2018 ;74(2):73-78

A seventysix-year-old female was acutely admitted to the Eye Clinic of the University Hospital in Martin with a 1 month history of impaired central and peripheral vision on the right eye. At the admission patient`s right eye VA was fingers at 20 cm, the left eye had a central vision preserved. Magnetic resonance of the brain and orbits demonstrated cystic tumor expansion in the sellar region with compression of optic chiasm and optic nerves (more on the right side), in diff. Read More

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January 2018
1 Read

Hormonal Risk Factors for Osteoporosis: Different Profile Among Antipsychotics.

J Child Adolesc Psychopharmacol 2018 Nov 13. Epub 2018 Nov 13.

1 Department of Child and Adolescent Psychiatry, Assistance Publique-Hôpitaux de Paris, University Hospital Pitié-Salpêtrière , Paris, France .

Objectives: Osteoporosis is a major risk factor for fracture and treatment is mainly preventive. Patients with severe psychiatric condition and treated with antipsychotics are at risk for vitamin D deficiency and iatrogenic hyperprolactinemia, two serious risk factors of osteoporosis. We aim to determine whether all antipsychotics are similar regarding the risk of osteoporosis in young patients. Read More

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November 2018
1 Read

Psychological effects of Dopamine Agonist Treatment in Patients with Hyperprolactinemia and Prolactin Secreting Adenomas.

Eur J Endocrinol 2018 Oct 1. Epub 2018 Oct 1.

L Katznelson, Department of Medicine, Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, Stanford, United States.

Background: Dopamine agonists (DAs) are the main treatment for patients with hyperprolactinemia and prolactinomas. Recently, an increasing number of reports emphasized DAs' psychological side effects, either de- novo or as exacerbations of prior psychiatric disease.

Methods: Review of prospective and retrospective studies (PubMed 1976- September 2018) evaluating the psychological profile of DAs-treated patients with hyperprolactinemia and prolactinomas. Read More

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October 2018
3 Reads

Chronic estrogen affects TIDA neurons through IL-1β and NO: effects of aging.

J Endocrinol 2018 Nov 1. Epub 2018 Nov 1.

P MohanKumar, Veterinary Biosciences and Diagnostic Imaging, University of Georgioa, Athens, United States.

Women are chronically exposed to estrogens through oral contraceptives, hormone replacement therapy or environmental estrogens. We hypothesized that chronic exposure to low levels of estradiol-17β (E2) can induce inflammatory and degenerative changes in the tuberoinfundibular dopaminergic (TIDA) system leading to reduced dopamine synthesis and hyperprolactinemia. Young (Y; 3-4 months) and middle-aged (MA; 10-12 months) Sprague-Dawley rats that were intact or ovariectomized (OVX), were either sham-implanted or implanted with a slow-release E2 pellet (20ng E2/day for 90 days). Read More

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November 2018
6 Reads

Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey.

J Clin Res Pediatr Endocrinol 2018 Nov 5. Epub 2018 Nov 5.

Objective: We aimed to study the characteristics on admission, diagnosis, treatment, and follow-up of hyperprolactinemic cases in a large multicenter study.

Methods: We reviewed 233 hyperprolactinemic patients under 18 years of age who were followed by different centers. The patients were divided as having microadenomas, macroadenomas, drug-induced hyperprolactinemia, and idiopathic hyperprolactinemia. Read More

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November 2018
4 Reads

Giant Prolactinoma in Men: Clinical Features and Therapeutic Outcomes.

Horm Metab Res 2018 Nov 5;50(11):791-796. Epub 2018 Nov 5.

Department of Endocrinology, Hospital Universitario Ramón y Cajal, Madrid, Spain.

The aim of the study was to evaluate the clinical features and long-term therapeutic outcome of giant prolactinoma (gPRLoma) in men and to compare them with those of a group of male patients with non-gPRL macroprolactinomas (non-gPRLomas). A retrospective and multicenter study of gPRLomas in men diagnosed in a 20-year period was performed. Clinical data and treatment outcome were registered. Read More

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November 2018
9 Reads

Ca2+ Channels in Anterior Pituitary Somatotrophs: A Therapeutic Perspective.

Endocrinology 2018 Dec;159(12):4043-4055

Department of Medical Neurobiology, Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University Faculty of Medicine, Jerusalem, Israel.

Ca2+ influx through voltage-gated Ca2+ channels (VGCCs) plays a key role in GH secretion. In this review, we summarize the current state of knowledge regarding the physiology and molecular machinery of VGCCs in pituitary somatotrophs. We next discuss the possible involvement of Ca2+ channelopathies in pituitary disease and the potential use of Ca2+ channel blockers to treat pituitary disease. Read More

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December 2018
3 Reads

Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma.

Radiother Oncol 2018 Oct 30. Epub 2018 Oct 30.

Department of Medicine I, Division of Oncology, Comprehensive Cancer Center, Medical University of Vienna, Austria.

Background: So far, the development and course of therapy-induced deficiencies in hypothalamic-pituitary hormones in adult patients with malignant gliomas has not received much attention. However, such deficiencies may impact patient's quality of life substantially.

Methods: In this monocentric longitudinal trial, we examined hormonal levels of TSH, T3, T4, fT3, fT4, FSH, LH, testosterone, estradiol and prolactin in patients with malignant high grade gliomas before the start of radiochemotherapy (RCT), at the end of RCT and then every three months for newly diagnosed patients and every six months in patients diagnosed more than two years before study inclusion. Read More

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October 2018
6 Reads

СLINICAL AND LABORATORY CHARACTERISTICS OF PATIENTS WITH ADOLESCENCE ACNE AND ACNE TARDA.

Georgian Med News 2018 Sep(282):103-106

JSC "Astana Medical University", Kazakhstan.

Acne is a chronic recurrent androgen-mediated disease of the pilosebaceous complex with a multifactorial genetically determined development mechanism. Currently, there is a tendency to persistent course of the disease, resistance to therapy forms of acne, late debut and change the clinical picture of acne. This could be due to various factors, such as polycystic ovary syndrome, microadenoma and pituitary adenoma, congenital adrenal hyperplasia, SAHA syndrome, etc. Read More

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September 2018
1 Read

Management of prolactinoma: a survey of endocrinologists in China.

Endocr Connect 2018 Oct;7(10):1013-1019

Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Objective To assess the current management of prolactinoma among endocrinologists in China. Methods An online survey of a large sample of endocrinologists was conducted in China. The questionnaire included 21 questions related to controversial issues about the management of prolactinomas. Read More

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October 2018
4 Reads

Repurposing of Bromocriptine for Cancer Therapy.

Front Pharmacol 2018 8;9:1030. Epub 2018 Oct 8.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.

Bromocriptine is an ergot alkaloid and dopamine D receptor agonist used to treat Parkinson's disease, acromegaly, hyperprolactinemia, and galactorrhea, and more recently diabetes mellitus. The drug is also active against pituitary hormone-dependent tumors (prolactinomas and growth-hormone producing adenomas). We investigated, whether bromocriptine also inhibits hormone-independent and multidrug-resistant (MDR) tumors. Read More

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October 2018
9 Reads

Hyperprolactinemia / Prolactinomas in the post-menopausal period:

challenges in diagnosis and management

.

Neuroendocrinology 2018 Oct 22. Epub 2018 Oct 22.


Hyperprolactinemia is not a common finding in post-menopausal women. Prolactinomas detected after menopause are usually macroadenomas. Due to atypical clinical features they may remain un-recognized for a long period of time. Read More

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October 2018
1 Read

Chronic estradiol exposure – harmful effects on behavior, cardiovascular and reproductive functions

Reproduction 2018 Sep 17. Epub 2018 Sep 17.

Department of Veterinary Biosciences and Diagnostic Imaging, University of Georgia, Athens, Georgia, USA

Estradiol (E2) is a female hormone that is produced largely by the ovaries, but also by the adrenal glands, fat and liver. It is present in the circulation of both males and females. Many studies in the literature have described how E2 is beneficial to the body in terms of preventing bone loss, affording protection in ischemia reperfusion injury, relieving symptoms of menopause, maintaining vaginal health and helping with ovarian failure or hypogonadism. Read More

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September 2018
5 Reads

MANAGEMENT OF ENDOCRINE DISEASE: Impulse control disorders in patients with hyperpolactinemia treated with dopamine agonists: how much should we worry?

Eur J Endocrinol 2018 Dec;179(6):R287-R296

Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Dopamine agonists (DAs) represent a cornerstone in the management of patients with hyperprolactinemia and have an important role in the treatment of neurologic disorders, including Parkinson's disease and restless legs syndrome. A growing body of evidence has identified impulse control disorders (ICDs) as possible adverse effects of DA therapy. A variety of ICDs may occur in patients treated with DA, including compulsive shopping, pathologic gambling, stealing, hypersexuality and punding (repetitive performance of tasks, such as collecting, sorting, disassembling and assembling objects). Read More

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December 2018
7 Reads

A Novel Mutation of in a Patient with Schaaf-Yang Syndrome and Hypopituitarism.

Int J Endocrinol Metab 2018 Jul 1;16(3):e67329. Epub 2018 Jul 1.

Neuropediatric Section, University and Polytechnic Hospital La Fe, Valencia, Spain.

Introduction: Schaaf-Yang syndrome (SYS) is caused by truncating point mutations of the paternal allele of , an imprinted gene located in the critical region of Prader-Willi syndrome (PWS). These patients present a phenotype with neurodevelopmental delay, hypotonia, joint contractures, and a particularly high prevalence of autism (up to 75% in affected individuals). The loss of function of is suggested to contribute to endocrine hypothalamic dysfunction in individuals with PWS. Read More

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July 2018
7 Reads

Hypothalamic and pituitary dysfunction is common in tubercular meningitis: A prospective study from a tertiary care center in Northern India.

J Neurol Sci 2018 Dec 9;395:153-158. Epub 2018 Oct 9.

Department of Neurology, PGIMER, Chandigarh, India.

Introduction: Current literature is poor with respect to well conducted prospective studies of hypothalamic pituitary axis (HPA) dysfunction in tubercular meningitis (TBM). As hormonal deficiencies are associated with poor clinical outcome in various neurological and non-neurological disorders, we prospectively evaluated the hypothalamic pituitary axis (HPA) dysfunction in TBM.

Patients And Methods: Present study included newly diagnosed drug naive TBM patients (n = 63) at a tertiary care centre in Northern India. Read More

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December 2018
2 Reads

A case of a Müllerian cyst arising in the posterior mediastinum.

Oxf Med Case Reports 2018 Nov 9;2018(11):omy080. Epub 2018 Oct 9.

Department of Thoracic and Cardiovascular Surgery, Nara Medical University School of Medicine, Kashihara, Nara, Japan.

A mediastinal Müllerian cyst is composed of heterotopic cystic Müllerian tissue resembling structures of the fallopian tube. We herein report a case of a mediastinal Müllerian cyst discovered during a medical check-up of a 41-year-old woman. She had no symptoms but had been diagnosed with hyperprolactinemia at the age of 24 years, for which she received hormonal therapy for 3 years. Read More

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November 2018
1 Read

MECHANISMS OF ENDOCRINOLOGY: Endocrinology of opioids

Eur J Endocrinol 2018 10 1;179(4):R183-R196. Epub 2018 Oct 1.

Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

The use of opioids has grown substantially over the past two decades reaching the dimensions of a global epidemic. These drugs have effects on multiple levels of the endocrine system through mechanisms which are still not fully elucidated, and awareness of their endocrine sequelae is vital for all specialists prescribing or managing patients on them. Hypogonadism is the most well-recognised consequence of opioid use (prevalence 21–86%) which, however, may remain undiagnosed with potential adverse outcomes for the patients. Read More

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October 2018
2 Reads

Paradoxical GH increase during OGTT is associated to first-generation somatostatin analogs responsiveness in acromegaly.

J Clin Endocrinol Metab 2018 Oct 3. Epub 2018 Oct 3.

Department of Biology, University of Padova, Padova, Italy.

Context: The oral glucose tolerance test (OGTT) is considered the most useful method for diagnosing active acromegaly and for patient follow-up after neurosurgery. Despite its widespread use, only a few small studies have so far focused on patients' clinical features associated with different GH responsiveness to OGTT.

Objective: We aimed to investigate the association between glucose-induced GH response and endocrine profiles, clinical manifestations, and response to therapy in a large cohort of patients with acromegaly. Read More

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October 2018
10 Reads

Posterior pituitary tumours: the spectrum of a unique entity. A clinical and histological study of a large case series.

Endocrine 2018 Oct 1. Epub 2018 Oct 1.

Department of Endocrinology, Hospital Universitari de Bellvitge, Barcelona, Spain.

Purpose: In 2017, the WHO established that pituicytoma, granular cell tumour (GCT) and spindle cell oncocytoma (SCO) are posterior pituitary tumours (PPT). Recent data suggests that these tumours probably arise from the pituicytes and may constitute a spectrum of a unique histopathological entity. Our aim is to report the clinical findings and surgical outcomes of 16 patients with PPT. Read More

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October 2018
3 Reads

Prevalence and reproductive manifestations of macroprolactinemia.

Endocrine 2018 Sep 29. Epub 2018 Sep 29.

Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.

Purpose: Macroprolactinemia is characterized by predominance of macroprolactin molecules in circulation and generally has extra-pituitary origin. Macroprolactin is viewed as biologically inactive, therefore asymptomatic, and thus may not require any treatment or prolonged follow-up. In addition, data on prevalence of macroprolactinemia and its clinical manifestation are also rare. Read More

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September 2018
1 Read

Idiopathic Hyperprolactinemia Presenting as Polycystic Ovary Syndrome in Identical Twin Sisters: A Case Report and Literature Review.

Cureus 2018 Jul 19;10(7):e3004. Epub 2018 Jul 19.

Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, IND.

This case report describes 15-year-old identical twin sisters, who presented to us with features of polycystic ovary syndrome (PCOS). A biochemical workup revealed hyperinsulinemia and androgen excess with elevated prolactin levels. The possible etiologies for hyperprolactinemia were excluded with a detailed evaluation and it was labeled as idiopathic. Read More

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July 2018
6 Reads

Prevalence and course of endocrinopathy in POEMS syndrome.

J Clin Endocrinol Metab 2018 Sep 17. Epub 2018 Sep 17.

Department of Endocrinology, University College London Hospitals NHS Foundation Trust, London, UK.

Context: POEMS syndrome is a rare multisystem disorder characterised by polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma-proliferative disorder and skin changes among other features.

Objective: To describe the prevalence and course of the endocrine dysfunction in the context of POEMS.

Design: Cohort study with systematic review of the endocrinopathy in POEMS. Read More

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September 2018
1 Read

Management of antipsychotic related hyperprolactinemia in older people: Can we extrapolate from existing guidance?

Int J Geriatr Psychiatry 2018 Dec 14;33(12):1743-1744. Epub 2018 Sep 14.

Division of Psychiatry, University College London, London, UK.

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December 2018
1 Read

A meta-analysis of the prevalence of cardiac valvulopathy in hyperprolactinemic patients treated with Cabergoline.

J Clin Endocrinol Metab 2018 Sep 11. Epub 2018 Sep 11.

Department of Endocrinology, St Bartholomew's Hospital, London.

Context: Cabergoline is first line treatment for most patients with lactotrope pituitary tumors and hyperprolactinemia. Its use at high-dose in Parkinson's disease has largely been abandoned, because of its association with the development of a characteristic restrictive cardiac valvulopathy. Whether similar valvular changes occur in patients receiving lower doses for treatment of hyperprolactinemia is unclear, although stringent regulatory recommendations for echocardiographic screening exist. Read More

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September 2018
1 Read

Aripiprazole combination for reversal of paliperidone-induced increase in prolactin level.

Neuropsychiatr Dis Treat 2018 27;14:2175-2179. Epub 2018 Aug 27.

Department of Psychiatry, Xi'an Mental Health Center, Institute of Mental Health, Xi'an Medical University, Xi'an, China,

Hyperprolactinemia is a common side effect of antipsychotic drugs. Although changes of antipsychotic drugs or reduction of their doses can solve this problem, a modification of the treatment regimen can lead to instability in patients. Herein, we followed up a patient with elevated prolactin caused by paliperidone and found that the prolactin level was decreased after the administration of a combination with a low-dose aripiprazole. Read More

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August 2018
2 Reads

Using domperidone to induce and sustain hyperprolactinemia in late-pregnant gilts.

Domest Anim Endocrinol 2019 Jan 17;66:14-20. Epub 2018 May 17.

Department of Animal Science, University of California Davis, Davis, CA, USA.

Prolactin controls mammary development as well as the lactogenic and galactopoietic processes in sows and increasing prolactin during gestation can augment milk yield. The dopamine receptor antagonist domperidone can increase circulating prolactin concentrations in pigs, but the ideal dose to achieve sustained hyperprolactinemia remains unknown. An experiment was performed to develop a protocol for using domperidone in studies of rapid and sustained hyperprolactinemia in late-pregnant gilts. Read More

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January 2019
1 Read

[Importance of the exhaustive anamnesis to an unexplained unilateral gynecomastia in a child].

Arch Argent Pediatr 2018 Oct;116(5):e655-e658

Unidad de Endocrinología Pediátrica, Hospital Universitario Reina Sofía (Córdoba), España.

Gynecomastia consists of breast enlargement due to a hormonal imbalance between estrogens and androgens. Unilateral and important breast growth requires ruling underlying pathologic disorders out. Mechanical cause is uncommon, causing enlargement by repeated stimulation. Read More

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October 2018
2 Reads

A real-world analysis of healthcare costs and relative risk of hyperprolactinemia associated with antipsychotic treatments in the United States.

J Med Econ 2018 Dec 26;21(12):1183-1190. Epub 2018 Sep 26.

a Analysis Group, Inc. , Montreal , QC , Canada.

Aims: Antipsychotic medications are associated with an increased risk of hyperprolactinemia, but differ in their propensity to cause this complication. This study aimed to assess the economic burden of hyperprolactinemia, and to compare its risk among adult patients using atypical antipsychotics (AAs) with a mechanism of action associated with no/low vs high/moderate prolactin elevation.

Methods: This retrospective cohort study was based on US Commercial and Medicaid claims databases. Read More

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December 2018
2 Reads

Etiological Profile of Galactorrhoea.

Indian J Endocrinol Metab 2018 Jul-Aug;22(4):489-493

Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Center, Bengaluru, Karnataka, India.

Background: Recent increase in the non-specific use of prokinetics in clinical practice may alter the etiological profile of hyperprolactinemia and galactorrhea. Hence, we have studied the etiological profile of patients presenting with galactorrhea and characteristics of drug-induced galactorrhea.

Materials And Methods: This retrospective study was conducted at a tertiary health care center from South India. Read More

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August 2018
12 Reads

Clinical and Radiographic Characteristics Related to Hyperprolactinemia in Nonfunctioning Pituitary Adenomas.

World Neurosurg 2018 Nov 23;119:e1035-e1040. Epub 2018 Aug 23.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Pituitary Center, Seoul National University College of Medicine, Seoul, Korea.

Objective: Hyperprolactinemia in patients with nonfunctioning pituitary adenomas (NFPAs) has been explained by the stalk compression of large pituitary adenomas. However, not all large NFPAs are associated with high serum prolactin levels. We aimed to elucidate and compare clinical, hormonal, and radiographic characteristics of NFPAs with and without hyperprolactinemia. Read More

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November 2018
9 Reads
2.420 Impact Factor

Expression of prolactin receptors in the duodenum, kidneys and skeletal system during physiological and sulpiride-induced hyperprolactinaemia.

Endocrine 2018 Dec 24;62(3):681-691. Epub 2018 Aug 24.

Medical Faculty, University of Nis, Blvd.dr Zoran Djindjic 81, 18000, Nis, Serbia.

Introduction And Aim: Hyperprolactinaemia in pregnancy leads to mild and reversible changes in the maternal skeletal system, and medicamentous hyperprolactinemia causes more detrimental effects. We conducted an experimental study to evaluate differences between Prlr gene expression in the duodenum, vertebrae and kidneys during physiological and medicamentous hyperprolactinaemia, which could influence calcium homeostasis.

Methods: Experimental animals (18 weeks old, Wistar female rats) were divided as follows: group P (nine rats that were 3 weeks pregnant), group M (ten rats that were intramuscularly administrated sulpiride (10 mg/kg) twice daily for 3 weeks), and the control group (C, ten age-matched nulliparous rats, 18-week-old). Read More

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December 2018
1 Read
3.530 Impact Factor

Predictors of Postoperative Diabetes Insipidus Following Endoscopic Resection of Pituitary Adenomas.

J Endocr Soc 2018 Sep 27;2(9):1010-1019. Epub 2018 Jul 27.

Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Context: The development of diabetes insipidus (DI) following transsphenoidal resection of pituitary adenomas has been associated with higher postsurgical morbidity and longer hospitalizations. Identifying these patients promptly and efficiently can lead to improved health care outcomes.

Objective: We evaluated our institution's incidence of DI following pituitary adenoma resection and assessed for preoperative risk factors that were associated with postoperative DI. Read More

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September 2018
3 Reads

Prolactin-Secreting Lung Adenocarcinoma Metastatic to the Pituitary Mimicking a Prolactinoma: A Case Report.

Neurosurgery 2018 Aug 20. Epub 2018 Aug 20.

Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background And Importance: Metastasis to the pituitary gland is uncommon in patients with systemic disseminated cancer. Individual articles have reported cases of pituitary metastasis mimicking a prolactinoma, but no case of a prolactin-secreting tumor metastasizing to the pituitary mimicking a prolactinoma has been reported so far.

Clinical Presentation: This article reports a 67-yr-old man with a recent onset of headaches, ophthalmoplegia, hypopituitarism, and hyperprolactinemia who was initially diagnosed with prolactinoma and given bromocriptine in the local hospital. Read More

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August 2018
4 Reads

Different Effects of Atorvastatin on Cardiometabolic Risk Factors in Young Women With and Without Hyperprolactinemia.

J Clin Pharmacol 2018 Aug 21. Epub 2018 Aug 21.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Long-term prolactin excess is often accompanied by numerous metabolic complications. No previous study has compared the effect of statin therapy on circulating levels of cardiometabolic risk factors in patients with elevated and normal prolactin levels. The study population consisted of 3 age-, weight-, and lipid-matched groups of young women: 19 women with untreated hyperprolactinemia (group A), 20 normoprolactinemic women receiving bromocriptine treatment (because of previous hyperprolactinemia) (group B), and 20 untreated women with prolactin levels within the reference range (group C). Read More

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August 2018
5 Reads

Multiple endocrine neoplasia type 1 presenting with concurrent insulinoma and prolactinoma in early-adolescence.

Int J Pediatr Endocrinol 2018 6;2018. Epub 2018 Aug 6.

Department of Pediatrics, Johns Hopkins University School of Medicine, 200 N Wolfe St, Rm 3120, Baltimore, MD 21287 USA.

Background: Multiple Endocrine Neoplasia Type 1 (MEN1) is a rare autosomal dominant disease that generally presents with primary hyperparathyroidism. However, initial presentation may vary and continued reevaluation of etiology of symptoms is required for appropriate diagnosis.

Case Presentation: Twelve year old female presented with altered mental status that self-resolved and hypoglycemia. Read More

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August 2018
10 Reads

Cordycepin modulates body weight by reducing prolactin via an adenosine A1 receptor.

Curr Pharm Des 2018 Aug 20. Epub 2018 Aug 20.

Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine Jilin University, Changchun 130062. China.

Cordycepin is an extract from the insect fungus Cordyceps. militaris with various biological function. In previous studies, cordycepin had been reported with excellent anti-obesity effect, but the mechanism is unclear. Read More

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August 2018
1 Read
3.450 Impact Factor

Amenorrhea as a Side Effect of Low Dose Aripiprazole: An Adolescent Case.

Clin Psychopharmacol Neurosci 2018 Aug;16(3):343-345

Department of Child and Adolescent Psychiatry, Aksaray State Hospital, Aksaray, Turkey.

Amenorrhea, oligomenorrhea, galactorrhoea, gynecomastia, infertility, and sexual dysfunction may arise as a consequence of hyperprolactinemia. Hyperprolactinemia is one of major side effects of treatment with antipsychotics, but aripiprazole is known as a dopamine stabilizer antipsychotic which can be used to improve hyperprolactinemia. In this report, it was described that an adolescent patient experienced amenorrhea after adding very low dose aripiprazole to ongoing fluoxetine treatment regime for major depressive disorder. Read More

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August 2018
6 Reads

Mixed gangliocytoma-pituitary adenoma in the sellar region: a large-scale single-center experience.

Acta Neurochir (Wien) 2018 Oct 14;160(10):1989-1999. Epub 2018 Aug 14.

Department of Neurosurgery, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China.

Background: Mixed gangliocytoma-pituitary adenoma is an extremely rare tumor occurring in the sellar region, histologically composed of both gangliocytic and pituitary adenomatous architectures. The histogenesis of these tumors remains unknown, and the diagnosis, treatment, and prognosis are yet to be fully understood.

Methods: We retrospectively reviewed the clinical, radiological, and histopathological profiles from a series of 20 patients with sellar mixed gangliocytoma-pituitary adenomas. Read More

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October 2018
13 Reads
1.790 Impact Factor