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    1 OF 133

    Joint approach based on clinical and imaging features to distinguish non-neoplastic from neoplastic pituitary stalk lesions.
    PLoS One 2017 15;12(11):e0187989. Epub 2017 Nov 15.
    Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
    Purpose: Distinguishing non-neoplastic pituitary stalk lesions (non-NPSLs) from neoplastic pituitary stalk lesions (NPSLs) is a major concern in guiding treatment for a thickened pituitary stalk. Our study aimed to aid provide preoperative diagnostic assistance by combining clinical and magnetic resonance imaging (MRI) findings to distinguish non-NPSLs from NPSLs.

    Materials And Methods: We recruited 158 patients with thickened pituitary stalk lesions visible on MRI. Read More

    Antipsychotic-induced hyperprolactinaemia: case studies and review.
    Postgrad Med J 2017 Nov 9. Epub 2017 Nov 9.
    Consultant Psychiatrist, Adult Mental Health Inpatient Unit, Rotherham Doncaster and South Humber Mental Health NHS Foundation Trust, Doncaster, UK.
    Antipsychotics are a known cause of hyperprolactinaemia and can be associated with significant health issues in short term and long term. The effects vary with gender and age of the individual and can contribute towards non-concordance and hence relapse in mental health of our patients. Clinicians need to educate the patients about this significant side effect of not only antipsychotic medications but other medications causing hyperprolactinaemia commonly prescribed in primary care. Read More

    Antipsychotic polypharmacy in older Australians.
    Int Psychogeriatr 2017 Nov 10:1-8. Epub 2017 Nov 10.
    Quality Use of Medicines and Pharmacy Research Centre,School of Pharmacy and Medical Sciences,Sansom Institute,University of South Australia,Adelaide,South Australia,Australia.
    Background: Antipsychotics are commonly used, and the rate of use is highest, among those aged 65 years or over, where the risk of adverse events is also high. Up to 20% of younger adults use more than one antipsychotic concurrently; however there are few studies on the prevalence of antipsychotic polypharmacy in older people. We aimed to analyze antipsychotic use in elderly Australians, focusing on the prevalence of antipsychotic polypharmacy and the use of medicines to manage adverse events associated with antipsychotics. Read More

    [Valvular heart disease in relation to the treatment of hyperprolactinemia with dopamine agonists].
    Vnitr Lek 2017 ;63(9):561-565
    Adverse effect of dopamine agonists on the heart valves aroused much attention some time ago. Gradually, as data accumulated, the approach to the problem was rationalised and further examinations were only recommended in indicated cases. The paper reviews the current knowledge about the treatment of hyperprolactinemia with dopamine agonists and the risk of valvular disease. Read More

    Three Cases of Hair Loss Analyzed by the Point of View of the Analytical Psychology.
    Int J Trichology 2017 Oct-Dec;9(4):177-180
    Department of Clinical Psychology, Pontifícia universidade Católica de São Paulo, São Paulo, Brazil.
    Psychotrichology is the science, which covers the psychosomatics applied to hair problems, i.e., body-psyche phenomena involving scalp and hair disorders. Read More

    Calcium and Vitamin D Supplementation in Boys with Risperidone-Induced Hyperprolactinemia: A Randomized, Placebo-Controlled Pilot Study.
    J Child Adolesc Psychopharmacol 2017 Nov 7. Epub 2017 Nov 7.
    5 Department of Internal Medicine, The University of Iowa , Iowa City, Iowa.
    Background: The chronic use of antipsychotics has been associated with impaired bone mineralization, partially mediated by hyperprolactinemia. We examined if calcium and vitamin D supplementation promote bone mineral accrual in boys with risperidone-induced hyperprolactinemia.

    Methods: Between February 2009 and November 2013, medically healthy, 5- to 17-year-old boys were enrolled in a 36-week double-blind, placebo-controlled study, examining the skeletal effects of supplementation with 1250 mg calcium carbonate and 400 IU of vitamin D3 in risperidone-induced hyperprolactinemia. Read More

    A phase II study to evaluate the pharmacokinetics, safety, and tolerability of Risperidone ISM multiple intramuscular injections once every 4 weeks in patients with schizophrenia.
    Int Clin Psychopharmacol 2017 Nov 3. Epub 2017 Nov 3.
    aLaboratorios Farmacéuticos ROVI, Madrid, Spain bCBH Health, LLC, Rockville, Maryland, USA.
    This study characterized the pharmacokinetics, safety, and tolerability of Risperidone ISM, a new long-acting intramuscular formulation, for monthly administration without oral supplementation. Patients with schizophrenia received multiple intramuscular injections of 75 mg in the gluteal or deltoid muscle at 28-day intervals. Of the 70 randomized patients, 67 received at least one dose of study medication. Read More

    [Indications for surgical treatment of prolactin-secreting pituitary adenomas].
    Zh Vopr Neirokhir Im N N Burdenko 2017 ;81(5):117-124
    Burdenko Neurosurgical Institute named, Moscow, Russia.
    Prolactinomas account for about 40% of all pituitary adenomas. The main treatment for prolactinomas is undoubtedly therapy with dopamine agonists (DAs). However, prolonged conservative treatment (for many years or even throughout life) that is necessary for permanent control of the disease makes some patients refuse pharmacological treatment for various reasons. Read More

    Presentation, Treatment, and Long-Term Outcome of Intrasellar Chordoma: A Pooled Analysis of Institutional, SEER (Surveillance Epidemiology and End Results), and Published Data.
    World Neurosurg 2017 Oct 20. Epub 2017 Oct 20.
    Computational Neurosciences Outcomes Center, Department of Neurosurgery, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    Background: Chordoma that occurs primarily in the sella turcica is rare and presents unique treatment challenges.

    Objective: The purpose of this study was to determine common features, treatment approaches, and survival characteristics of intrasellar chordoma.

    Methods: Institutional databases, the SEER (Surveillance Epidemiology and End Results) database, and PubMed/EMBASE were queried for chordoma with a primarily intrasellar component. Read More

    Males with prolactinoma are at increased risk of incident cardiovascular disease.
    Clin Endocrinol (Oxf) 2017 Oct 16. Epub 2017 Oct 16.
    Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
    Objective: To investigate whether the risk of incident cardiovascular disease (CVD) is increased in patients with prolactinoma.

    Design: Population-based, retrospective, open-cohort study using The Health Improvement Network (THIN) database.

    Patients: A total of 2233 patients with prolactinoma and 10 355 matched controls (1:5 ratio) from UK General Practices contributing to THIN were included. Read More

    Optimal timing of dopamine agonist withdrawal in patients with hyperprolactinemia: a systematic review and meta-analysis.
    Endocrine 2017 Oct 17. Epub 2017 Oct 17.
    Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.
    Purpose: Dopamine agonists (DAs) are recommended as first-line treatment for patients with hyperprolactinemia. Generally, it is accepted that patients with hyperprolactinemia do not need lifelong medication, but the optimal timing for DA withdrawal has not been determined. The aim of this systematic review and meta-analysis is to assess the impact of DA withdrawal on the clinical outcomes of patients with hyperprolactinemia, and to explore possible factors affecting successful DA withdrawal. Read More

    [Potential clinical application of Kisspeptin in reproductive endocrinology].
    Zhejiang Da Xue Xue Bao Yi Xue Ban 2017 May;46(3):328-333
    Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
    Gonadotropin-releasing hormone (GnRH) plays an important role in the process of reproduction. Studies have shown that a family of peptides Kisspeptin can act on GnRH-related neurons, stimulating the secretion of GnRH, and activating the hypothalamic-pituitary-gonadal axis. Both animal experiments and clinical studies have shown that exogenous administration of Kisspeptin is able to induce physiological GnRH release in healthy individuals and those with endocrine-disorders, which brings great hope for treatment of reproductive endocrine diseases. Read More

    Mining comorbidity patterns using retrospective analysis of big collection of outpatient records.
    Health Inf Sci Syst 2017 Dec 28;5(1). Epub 2017 Sep 28.
    Medical University Sofia, University Specialised Hospital for Active Treatment of Endocrinology, Sofia, Bulgaria.
    Background: Studying comorbidities of disorders is important for detection and prevention. For discovering frequent patterns of diseases we can use retrospective analysis of population data, by filtering events with common properties and similar significance. Most frequent pattern mining methods do not consider contextual information about extracted patterns. Read More

    Improvement in cognitive abilities following cabergoline treatment in patients with a prolactin-secreting pituitary adenoma.
    Int Clin Psychopharmacol 2017 Oct 13. Epub 2017 Oct 13.
    Departments of aMental Health, CIBERSAM bEndocrinology, Corporació Sanitària Parc Taulí, Sabadell, Spain.
    Hyperprolactinaemia may affect sexual and reproductive functioning. However, recent studies suggest that increased prolactin levels may also have negative effects on cognition. We aimed to study whether the reduction in prolactin levels by cabergoline in patients with hyperprolactinaemia is followed by an improvement in cognitive tasks. Read More

    SUBCLINICAL IMPAIRMENT OF THE LEFT VENTRICULAR LONGITUDINAL FUNCTION IN PATIENTS WITH PROLACTINOMAS.
    Endocr Pract 2017 Oct 11. Epub 2017 Oct 11.
    From: Department of Neurosurgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
    Purpose Hyperprolactinemia has been associated with endothelial dysfunction and a wide range of cardiovascular risk factors, thus it can potentially lead to cardiac dysfunction. The present study was designed to interrogate our hypothesis that hyperprolactinemia can contribute to preclinical impaired left ventricular function. Patients and Methods Thirty-one prolactinoma patients and sixty healthy volunteers were prospectively recruited. Read More

    Psychiatric Patients with Antipsychotic Drug-Induced Hyperprolactinemia and Menstruation Disorders.
    Biol Pharm Bull 2017 ;40(10):1775-1778
    Division of Pharmacy, Ehime University Hospital.
    Treatment with antipsychotic drugs has been associated with hyperprolactinemia. The same antipsychotic drugs have also been associated with side effects such as menstruation disorders. The aim of this study was to evaluate the prevalence of hyperprolactinemia and menstruation disorders in women undergoing antipsychotic treatment. Read More

    Influence of sulpiride treatment on the level of prolactin and immunoglobulins in the peripheral blood of mares during the postpartum period.
    Acta Vet Hung 2017 09;65(3):417-428
    1 Institute of Veterinary Sciences, University of Agriculture in Kraków, al. Mickiewicza 24-28 , 30-059 Kraków , Poland.
    The aim of this study was to determine the effect of increased levels of prolactin (PRL) on the concentration of immunoglobulins in the blood, colostrum and milk of mares. The study was conducted on 12 mares of the Polish Pony breed (6 in the control and 6 in the experimental group). To induce hyperprolactinaemia in mares of the experimental group, 750 mg sulpiride was administered orally once a day. Read More

    Morbidity and mortality in patients with hyperprolactinaemia: the PROLEARS study.
    Endocr Connect 2017 Nov;6(8):580-588
    Division of Molecular and Clinical MedicineSchool of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
    Purpose: High serum prolactin concentrations have been associated with adverse health outcomes in some but not all studies. This study aimed to examine the morbidity and all-cause mortality associated with hyperprolactinaemia.

    Methods: A population-based matched cohort study in Tayside (Scotland, UK) from 1988 to 2014 was performed. Read More

    The mechanism of selfheal extract in treating hyperprolactinemia.
    Cancer Biomark 2017 Sep 15. Epub 2017 Sep 15.
    Department of Orthopaedics, Weifang People' s Hospital, Weifang, Shandong 261041, China.
    Objective: Selfheal has been used for many years in hyperprolactinemia induced galactorrhea, menstrual disorders, and dysgenesis with satisfactory curative effect. However, its mechanism is still unclear. This study intended to investigate the effect of selfheal extract on hyperprolactinemia in vivo and in vitro, in order to elucidate its mechanism of anti-hyperprolactinemia. Read More

    The efficacy of medical treatment in patients with acromegaly in clinical practice.
    Endocr J 2017 Sep 20. Epub 2017 Sep 20.
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
    Although somatostatin analogues (SSAs) are recommended as the first-line medical therapy for acromegaly, dopamine agonists (DAs) are also a therapeutic option for treatment. We aimed to assess and compare the efficacies of DAs and SSAs in treating acromegaly in clinical practice. We included 89 patients with acromegaly who took DAs (bromocriptine [BCT], n = 63; cabergoline [CAB], n = 11) or SSAs (n = 15) as a primary medical therapy for more than 3 months in the Seoul National University Hospital. Read More

    Steroids administered after vacuum-assisted biopsy in the management of idiopathic granulomatous mastitis.
    J Clin Pathol 2017 Oct 17;70(10):827-831. Epub 2017 Mar 17.
    Department of Pathology, Affiliated Calmaette Hospital of Kunming Medical University, Kunming, Yunnan, PR China.
    Aims: The aetiology and treatment options for idiopathic granulomatous mastitis (IGM) are controversial. The aim was to study the clinical and diagnostic features and discuss medical and surgical treatment for IGM in our patients.

    Methods: Sixty-five patients who met the histological criteria for IGM were retrospectively studied. Read More

    Resolution of dopamine agonist-resistant hyperprolactinemia by hysterectomy: a case report.
    Gynecol Endocrinol 2017 Sep 19:1-3. Epub 2017 Sep 19.
    a Department of Obstetrics and Gynecology , Hyogo Prefectural Amagasaki General Medical Center , Amagasaki , Japan.
    Prolactin-producing uterine leiomyomas are very rare. Although hyperprolactinemia rapidly improves after removal of such leiomyomas, no preoperative diagnostic test has been established for prolactin-producing uterine leiomyomas. A 45-year-old Japanese woman, gravida 3 para 3, was referred to our hospital for further examination of hyperprolactinemia resistant to a dopamine agonist. Read More

    Hypogonadotropic hypogonadism in human immunodeficiency virus-infected men: uncommonly low testosterone levels.
    Endocrinol Diabetes Metab Case Rep 2017 6;2017. Epub 2017 Sep 6.
    Endocrinology, Diabetes and Metabolism Department, Hospital de Santa Maria, Lisbon, Portugal.
    Hypogonadotropic hypogonadism (HH) is common and occurs prematurely in HIV-infected men. However, HH with very low testosterone has not been described. Three men with normal pubertal development and HIV1 diagnosis at the ages of 22, 34 and 35 years. Read More

    [Prolactin-secreting microadenoma in menopausal women].
    Pan Afr Med J 2017 5;27:177. Epub 2017 Jul 5.
    Service d'Endocrinologie, CHU Farhat Hached de Sousse, Tunisie.
    Prolactin-secreting adenoma is rare in elderly women. Patient's clinical picture may be confused with that of menopause, making diagnosis sometimes difficult. We report the case of a 57-year old woman with a 2-year history of secondary amenorrhea without hot flushes associated with galactorrhea in order to highlight the peculiarities of prolactin-secreting microadenomas. Read More

    Antipsychotic-induced hyperprolactinemia: synthesis of world-wide guidelines and integrated recommendations for assessment, management and future research.
    Psychopharmacology (Berl) 2017 Nov 9;234(22):3279-3297. Epub 2017 Sep 9.
    The Monash Alfred Psychiatry Research Centre, Monash University, Level 4, 607 St Kilda Rd, Melbourne, 3004, Victoria, Australia.
    Rationale: Hyperprolactinemia is a highly prevalent adverse effect of many antipsychotic agents, with potentially serious health consequences. Several guidelines have been developed for the management of this condition; yet, their concordance has not been evaluated.

    Objectives: The objectives of this paper were (1) to review current clinical guidelines; (2) to review key systematic evidence for management; and (3) based on our findings, to develop an integrated management recommendation specific to male and female patients who are otherwise clinically stabilised on antipsychotics. Read More

    [The relationship between autoimmune thyroiditis and pregnancy outcomes of patients with PCOS following in vitro fertilization and embryo transfer IVF-ET].
    Zhonghua Yi Xue Za Zhi 2017 Sep;97(33):2609-2613
    Center of Reproductive Medicine, Peking University Third Hospital, Beijing 100191, China.
    Objective: To investigate the impact of autoimmune thyroiditis (AIT) on pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) following the in vitro fertilization and embryo transfer (IVF-ET) by analyzing their pregnancy outcomes. Methods: The patients undergoing IVF-ET treatment diagnosed with PCOS in Peking University Third Hospital from May 2010 to December 2014 were investigated. According to the anti-thyroid antibodies (TPOAb or TGAb), patients were divided into AIT group and non-AIT group. Read More

    Efficacy of Combined Cabergoline and Metformin Compared to Metformin Alone on Cycle Regularity in Patients with Polycystic Ovarian Disease with Hyperprolactinemia: A Randomized Clinical Trial.
    J Obstet Gynaecol India 2017 Oct 24;67(5):363-369. Epub 2017 Jun 24.
    Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
    Purpose: Polycystic ovarian syndrome (PCOS) is a common reproductive disorder. Increasing serum prolactin in these patients could be detected in both follicular and luteal phase of the normal and stimulated cycles. Hyperprolactinemia affects the hypothalamic-pituitary-ovarian axis causing anovulation and abnormal uterine bleeding. Read More

    Corynebacterium kroppenstedtii Is an Emerging Cause of Mastitis Especially in Patients With Psychiatric Illness on Antipsychotic Medication.
    Open Forum Infect Dis 2017 6;4(2):ofx096. Epub 2017 May 6.
    Queen Mary Hospital, Hong Kong.
    This retrospective study of patients with Corynebacterium kroppenstedtii infections revealed a predominance of mastitis and a potential association with psychiatric illnesses. At least one third of our patients with C kroppenstedtii mastitis had psychiatric illness, and >92% received antipsychotic medications. Drug-induced hyperprolactinemia may be an important modifiable risk factor in these patients. Read More

    Idiopathic granulomatous mastitis associated with hyperprolactinemia: A nonoperative approach.
    Breast J 2017 Nov 27;23(6):742-744. Epub 2017 Aug 27.
    Redcliffe Hospital, Redcliffe, QLD, Australia.
    There is increasing evidence associating idiopathic granulomatous mastitis (IGM) with hyperprolactinemia. All documented cases have involved the patient having at least one operative procedure before the association has been made. We present a 55 year old female with IGM associated with risperidone induced hyperprolactinemia. Read More

    Screening for valve disease in patients with hyperprolactinaemia disorders prescribed cabergoline: a service evaluation and literature review.
    Ther Adv Drug Saf 2017 Jul 25;8(7):215-229. Epub 2017 Apr 25.
    Cardiac Unit, Raigmore Hospital, NHS Highland, Old Perth Road, Inverness IV2 3UJ, UK.
    Objectives: The indication for screening for valvular heart disease in patients taking cabergoline is based on evidence from patients with Parkinson's disease on high-dose medication. However, current patients take much lower doses for indications such as hyperprolactinaemia disorders. Contemporary guidelines for echocardiogram monitoring in patients taking cabergoline are conflicting. Read More

    Vasculogenic hyperprolactinemia: severe prolactin excess in association with internal carotid artery aneurysms.
    Pituitary 2017 Dec;20(6):676-682
    Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia.
    Purpose: Internal carotid artery (ICA) aneurysms have rarely been found in association with marked hyperprolactinemia in the absence of prolactinoma; the cause of hyperprolactinemia has never been investigated. We aimed to determine if the observed hyperprolactinemia is due to a vascular-derived or known prolactin secretagogue from the injured ICA, analogous to pregnancy-associated hyperprolactinemia putatively due to placental factors.

    Methods: We conducted a case series and literature review of individuals with severe hyperprolactinemia in association with ICA aneurysms. Read More

    An Intact Dopamine Sensitivity in the Brain: A Necessity to Recover Hyperprolactinemia and Galactorrhea in a Female Hemodialysis Patient?
    Case Rep Nephrol 2017 16;2017:3729629. Epub 2017 Jul 16.
    Department of Endocrinology, University Hospital of Antwerp, Edegem, Belgium.
    A female hemodialysis patient with galactorrhea due to hyperprolactinemia was treated with different dialysis modalities to assess the effect on prolactin levels. A single session of both high-flux hemodialysis and hemodiafiltration resulted in decreased prolactin levels (16,6% and 77,2%, resp.). Read More

    DIAGNOSIS OF ENDOCRINE DISEASE: Primary empty sella: a comprehensive review.
    Eur J Endocrinol 2017 Dec 5;177(6):R275-R285. Epub 2017 Aug 5.
    Pituitary UnitDepartment of Endocrinology
    Primary empty sella (PES) is characterized by the herniation of the subarachnoid space within the sella, which is often associated with variable degrees of flattening of the pituitary gland in patients without previous pituitary pathologies. PES pathogenetic mechanisms are not well known but seem to be due to a sellar diaphragm incompetence, associated to the occurrence of upper sellar or pituitary factors, as intracranial hypertension and change of pituitary volume. As PES represents in a majority of cases, a neuroradiological findings without any clinical implication, the occurrence of endocrine, neurological and opthalmological symptoms, due to the above describes anatomical alteration, which delineates from the so called PES syndrome. Read More

    Metabolic syndrome in Iranian adolescents with polycystic ovary syndrome.
    Int J Adolesc Med Health 2017 Aug 5. Epub 2017 Aug 5.
    .
    Background Metabolic syndrome (MS) in adolescents is a risk factor for type 2 diabetes and cardiovascular diseases. Objective The present study aimed to determine the prevalence of MS in 14-18-year-old girls. Methods This analytical case-control study was conducted on 3200 high school students with polycystic ovarian syndrome (PCOS). Read More

    Pulmonary Artery Occlusion and Mediastinal Fibrosis in a Patient on Dopamine Agonist Treatment for Hyperprolactinemia.
    Front Pharmacol 2017 20;8:492. Epub 2017 Jul 20.
    Department of Cardiology, Aarhus University HospitalAarhus, Denmark.
    Unusual forms of pulmonary hypertension include pulmonary hypertension related to mediastinal fibrosis and the use of serotonergic drugs. Here, we describe a patient with diffuse mediastinal fibrosis and pulmonary hypertension while she was on dopamine agonist therapy. A young woman, who was treated with cabergoline and bromocriptine for hyperprolactinemia, presented with progressive dyspnea over several months. Read More

    Idiopathic Granulomatous Mastitis: A Clinical Puzzle in Breast Lump Cases.
    J Clin Diagn Res 2017 Jun 1;11(6):PD14-PD15. Epub 2017 Jun 1.
    Junior Resident, Department of General Surgery, SCB, Medical College, Cuttack, Odisha, India.
    Idiopathic granulomatous mastitis (IGM) is a rare benign disease, characterized by chronic inflammation and granulomatous disease process. A middle aged lady with breast lump for six months with equivocal mammographic and ultrasound results underwent lumpectomy and biopsy. Ruling out all other possible granulomatous diseases and malignancy, a diagnosis of IGM was made. Read More

    Effects of TNF-α on penile structure alteration in rats with hyperprolactinemia.
    PLoS One 2017 1;12(8):e0181952. Epub 2017 Aug 1.
    Department of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
    This study aimed to investigate the effects of anti-tumor necrosis factor (TNF)-α antibody (Ab) on alteration of penile structure in the hyperprolactinemia (hyperPRL) rat model. HyperPRL was induced in 8-week-old male Sprague-Dawley rats by allografting anterior pituitary (AP) glands under the renal capsule (+AP rats). Rats implanted with cerebral cortex (CX) were used as sham control (+CX rats). Read More

    Hyperprolactinaemia in first episode psychosis - A longitudinal assessment.
    Schizophr Res 2017 Jul 27. Epub 2017 Jul 27.
    Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; National Psychosis Service, South London and Maudsley NHS Foundation Trust, London, UK. Electronic address:
    Little is known about hyperprolactinaemia (HPL) in first episode psychosis (FEP) patients. We investigated longitudinal changes in serum prolactin in FEP, and the relationship between HPL, and antipsychotic medication and stress. Serum prolactin was recorded in FEP patients at recruitment and again, 3 and 12months later. Read More

    Antipsychotic-induced hyperprolactinemia in Tourette syndrome.
    Ther Adv Psychopharmacol 2017 Jul 21;7(6-7):201-205. Epub 2017 Apr 21.
    Diabeter, Center for Pediatric and Adolescent Diabetes Care and Research, Rotterdam, The Netherlands.
    For many years, Tourette syndrome (TS) was considered to be a rare disorder, but tics and TS are now recognized as fairly common childhood-onset conditions. Children and adolescents with TS are frequently treated with antipsychotics, either as monotherapy or in combination with psychostimulants, melatonin and selective serotonin reuptake inhibitors (SSRIs). Antipsychotics are most often used in schizophrenia and related psychotic disorders, and in these conditions hyperprolactinemia is one of the most common adverse effects associated with antipsychotics, occurring in 40-50% of patients. Read More

    Autoimmune hypothyroidism is three times more frequent in female prolactinoma patients compared to healthy women: data from a cross-sectional case-control study.
    Endocrine 2017 Jul 19. Epub 2017 Jul 19.
    University Hospital of Endocrinology, Sofia, Bulgaria.
    Background: The potent immunomodulatory action of prolactin has been demonstrated in many experimental in vitro studies. In accordance with these data, our retrospective analyses revealed higher prevalence of autoimmune thyroid diseases in prolactinoma patients compared to general population.

    Purpose: A cross-sectional case-control study was carried out in a single tertiary referral centre. Read More

    A study of neuroendocrine dysfunction in patients of tuberculous meningitis.
    J Neurol Sci 2017 Aug 13;379:198-206. Epub 2017 Jun 13.
    Department of Endocrinology, King George's Medical University, Lucknow, India.
    Background: Endocrine dysfunction is known to occur in various infectious diseases of the brain. The neuroendocrine dysfunction is not well studied in patients of Tuberculous meningitis (TBM). In this study, we aimed at knowing pattern of endocrine dysfunction in newly diagnosed patients of tuberculous meningitis, structural changes occurring in hypothalamic-pituitary region, assessing its predictors and correlative factors related to outcome. Read More

    Physical Health Outcomes in Preschoolers with Prior Authorization for Antipsychotics.
    J Child Adolesc Psychopharmacol 2017 Nov 14;27(9):833-839. Epub 2017 Jul 14.
    1 Department of Pharmaceutical Outcomes and Policy, University of Florida College of Pharmacy , Gainesville, Florida.
    Objective: To examine incidence of adverse health outcomes and associated factors among preschoolers (under age 6) who received antipsychotic treatment through the Florida Medicaid Prior Authorization (PA) program.

    Methods: Using Florida's PA registry linked to the state's Medicaid claims data, we ascertained incident outcomes during PA-approved antipsychotic use between April 2008 and September 2015 (7.5 years). Read More

    Pregnancy and Tumor Outcomes in Women with Prolactinoma.
    Exp Clin Endocrinol Diabetes 2017 Jul 13. Epub 2017 Jul 13.
    Faculty of Medicine, University of Porto. Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
    Context Management of prolactinomas during pregnancy has always been a challenge. There is a concern about the risk of tumor growth, as well as the effects of the treatment on the developing fetus. Another issue that has been less studied is the outcome of women with prolactinoma after pregnancy and lactation. Read More

    Insight into the Endocrine System and the Immune System: A Review of the Inflammatory Role of Prolactin in Rheumatoid Arthritis and Psoriatic Arthritis.
    Front Immunol 2017 23;8:720. Epub 2017 Jun 23.
    Laboratory of Translational Immunology, Department of Rheumatology and Clinical Immunology, University Medical Center, Utrecht, Netherlands.
    Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects females three times more frequently than males. A potential role for hormones, such as prolactin (PRL), may in part explain this phenomenon. The risk of developing RA is increased in women who are lactating after the first pregnancy, which might be related to breastfeeding and the release of PRL. Read More

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