7,079 results match your criteria Hyperprolactinemia


Metoclopramide induces preparturient, low-level hyperprolactinemia to increase milk production in primiparous sows.

Domest Anim Endocrinol 2020 Jul 3;74:106517. Epub 2020 Jul 3.

Department of Animal Science, University of California, Davis, CA 95616, USA. Electronic address:

Inadequate milk production by sows often limits the growth of piglets. A successful lactation requires prolactin (PRL)-induced differentiation of the alveolar epithelium within the mammary glands of sows between days 90-110 of gestation. We hypothesized that induction of late gestational hyperprolactinemia in primiparous sows by oral administration of the dopamine antagonist metoclopramide (MET) would enhance mammary epithelial differentiation, milk yield, and piglet growth rate and that these effects would carry over into a subsequent lactation. Read More

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http://dx.doi.org/10.1016/j.domaniend.2020.106517DOI Listing

Prolactinomas: Prognostic Factors of Early Remission After Transsphenoidal Surgery.

Front Endocrinol (Lausanne) 2020 7;11:439. Epub 2020 Jul 7.

Department of Gastroenterology, Endocrinology and Internal Diseases, Military Institute of Medicine, Warsaw, Poland.

Most patients with prolactinomas receive pharmacological treatment only, resulting in limited research on the predictors of successful prolactinoma surgery. In this study, we analyzed whether early postoperative serum prolactin concentrations and selected tumor characteristics could predict early, hormonal remission after removal of prolactinomas. We prospectively enrolled 48 consecutive patients with prolactinomas who underwent transsphenoidal resection performed by the same surgeon. Read More

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http://dx.doi.org/10.3389/fendo.2020.00439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358351PMC

Infiltrative lymphocytic hypophysitis successfully treated with rituximab and mycophenolate mofetil.

Endocrinol Diabetes Metab Case Rep 2020 Jul 29;2020. Epub 2020 Jul 29.

Department of Endocrinology and Diabetes, Royal North Shore Hospital, New South Wales, Australia.

Summary: Lymphocytic hypophysitis is a rare neuroendocrine disease characterised by an autoimmune inflammatory disorder of the pituitary gland. We report a 50-year-old woman who presented with headaches and bilateral sixth cranial nerve palsies. MRI of the pituitary revealed extensive fibrosis involving the sellar and extending into both cavernous sinuses causing bilateral occlusion of the internal carotid arteries (ICA). Read More

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http://dx.doi.org/10.1530/EDM-20-0041DOI Listing

FROM ERECTILE DYSFUNCTION TO BRAIN SUBEPENDYMOMA: A CASE REPORT.

Acta Clin Croat 2020 Mar;59(1):173-176

1Department of Internal Medicine, Osijek University Hospital Centre, Osijek, Croatia; 2Department of Internal Medicine, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 3Department of Physiology and Immunology, Faculty of Medicine, University of Osijek, Osijek, Croatia; 4Department of Psychiatry, Osijek University Hospital Centre, Osijek, Croatia; 5Department of Psychiatry, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 6University Hospital of Traumatology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 7Department of Surgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.

Endocrinopathies are relatively rare causes of erectile dysfunction. Cases of hyperprolactinemia and pituitary adenomas have been previously reported. We present a clinical case of a 27-year-old male with suspected infertility and recent symptoms of erectile dysfunction. Read More

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http://dx.doi.org/10.20471/acc.2020.59.01.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382887PMC

Unusual Combination of MEN-1 and the Contiguous Gene Deletion Syndrome of CAH and Ehlers-Danlos Syndrome (CAH-X).

J Endocr Soc 2020 Aug 27;4(8):bvaa077. Epub 2020 Jun 27.

Division of Endocrinology, Diabetes, and Metabolism. The Johns Hopkins University School of Medicine, Baltimore, Maryland.

The contiguous gene deletion syndrome of congenital adrenal hyperplasia and Ehlers-Danlos syndrome, named CAH-X, is a rare entity that occurs because of a deletion of a chromosomal area containing 2 neighboring genes, and . Here, we describe a patient from a consanguineous family in which coincidentally MEN-1 syndrome is associated with CAH-X, causing particular challenges explaining the phenotypic features of the patient. A 33-year-old man with salt-wasting congenital adrenal hyperplasia and classic-like Ehlers-Danlos syndrome presented with an adrenal crisis with a history of recurrent hypoglycemia, abdominal pain, and vomiting. Read More

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http://dx.doi.org/10.1210/jendso/bvaa077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371387PMC

Prevalence of hypopituitarism and quality of life in survivors of post-traumatic brain injury.

Endocrinol Diabetes Metab 2020 Jul 5;3(3):e00146. Epub 2020 Jun 5.

Endocrinology Unit Central Hospital of Army Algiers Algeria.

Background: Hypopituitarism is a recognized sequela of traumatic brain injury (TBI) and may worsen the quality of life (QoL) in survivors.

Aims: To assess the prevalence of post-traumatic hypopituitarism (PTHP) and growth hormone deficiency (GHD), and determine their correlation with QoL.

Methods: Survivors of moderate to severe TBI were recruited from two Algerian centres. Read More

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http://dx.doi.org/10.1002/edm2.146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375098PMC

Risk factors of hyperprolactinemia induced by risperidone and olanzapine and their correlations with plasma glucose and lipids.

Gen Psychiatr 2020 6;33(4):e100206. Epub 2020 Jul 6.

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Hyperprolactinemia is a common adverse reaction in patients with schizophrenia who take antipsychotic drugs; it often leads to treatment non-compliance in patients and has an adverse effect on their prognosis.

Aims: This study aimed to explore the risk factors of elevated prolactin (PRL) caused by risperidone (RIS) and olanzapine (OLZ) and the relationship between PRL and fasting plasma glucose and lipids.

Methods: Patients with schizophrenia were divided into two groups: 264 patients who were taking RIS and 175 patients who were taking OLZ. Read More

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http://dx.doi.org/10.1136/gpsych-2020-100206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342815PMC

Neuroendocrine carcinoma of the breast with hyperprolactinemia: report of two cases and a minireview.

Int J Clin Exp Pathol 2020 1;13(6):1457-1462. Epub 2020 Jun 1.

Department of Breast Surgery, The First Affiliated Hospital of Jinan University Guangzhou 510630, China.

Neuroendocrine carcinoma of the breast (NECB) is a rare type of breast cancer. The clinical features and morphology between NECB and other subtypes of breast cancer are indistinguishable. Currently, the diagnosis of NECB mainly relies on immunohistochemical markers including chromogranin and synaptophysin. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344007PMC

The association between prolactin concentration and aggression in female patients with schizophrenia.

World J Biol Psychiatry 2020 Jul 22:1-9. Epub 2020 Jul 22.

Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia.

Objectives: This study assessed the association between serum prolactin (PRL) concentration and aggression in female patients with schizophrenia.

Methods: Female patients with schizophrenia ( = 120) were diagnosed using SCID-5 based on the DSM-5 criteria. They were sampled at the University Psychiatric Hospital Vrapce during the period from March 2017 to March 2019. Read More

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http://dx.doi.org/10.1080/15622975.2020.1795254DOI Listing

Aripiprazole for the treatment of delusional disorders: A systematic review.

Gen Hosp Psychiatry 2020 Jun 26;66:34-43. Epub 2020 Jun 26.

Padua University Hospital, Padua, Italy.

Background: Delusional disorder is an uncommon psychotic disorder. The first-line treatments for this chronic and resistant condition are antipsychotic medications, usually associated with several side effects that can exacerbate poor adherence. Conversely, aripiprazole is a well-tolerated antipsychotic drug that is effective in the treatment of other psychotic disorders. Read More

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http://dx.doi.org/10.1016/j.genhosppsych.2020.06.012DOI Listing

Hyperprolactinaemia attenuates the inhibitory effect of vitamin D/selenomethionine combination therapy on thyroid autoimmunity in euthyroid women with Hashimoto's thyroiditis: A pilot study.

J Clin Pharm Ther 2020 Jul 10. Epub 2020 Jul 10.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

What Is Known And Objective: Vitamin D administered together with selenomethionine has been reported to markedly reduce thyroid antibody titres in patients with autoimmune thyroiditis. Hyperprolactinaemia exerts a complex pro-inflammatory effect. This study was aimed at investigating whether prolactin excess determines the effect of vitamin D/selenomethionine combination therapy on thyroid autoimmunity. Read More

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http://dx.doi.org/10.1111/jcpt.13214DOI Listing

Data of a meta-analysis on pharmacological treatment strategies for lowering prolactin in people with a psychotic disorder and hyperprolactinaemia.

Data Brief 2020 Aug 23;31:105904. Epub 2020 Jun 23.

Department of Mental Health, Hospital Universitari Parc Taulí, I3PT. Sabadell, Barcelona, Spain.

The data presented in this paper describe supplementary material to the article entitled "Pharmacological treatment strategies for lowering prolactin in people with a psychotic disorder and hyperprolactinaemia: a systematic review and meta-analysis" [1]. Although raw data was published on the original article, additional raw data has been included in the current paper (new tables with socio-demographic and clinical characteristics of the samples of the studies included in the systematic review). Supplementary data also include the PICO scheme of the systematic review, PRISMA checklist, flow diagram, an explanation of the method for obtaining prolactin concentrations from published figures when data was only available in figures, list of the selected studies, risk of bias summary of all five randomized clinical trials evaluating the addition of aripiprazole for lowering prolactin (included in the meta-analysis in the original article). Read More

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http://dx.doi.org/10.1016/j.dib.2020.105904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334589PMC

Comparative Study of the Effects of Chamomile ( L.) and Cabergoline on Idiopathic Hyperprolactinemia: A Pilot Randomized Controlled Trial.

Iran J Pharm Res 2019 ;18(3):1612-1621

Vali-e-Asr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Chamomile is a fascinating plant quoted in several traditional medicine texts, which has broad-spectrum pharmacological activity and medicinal uses. The aim of this study was to assess the efficacy of chamomile syrup in reducing serum prolactin in women with idiopathic hyperprolactinemia. The study was a randomized, controlled clinical trial that was conducted on 56 women with idiopathic hyperprolactinemia for a study period of four weeks. Read More

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http://dx.doi.org/10.22037/ijpr.2019.1100758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934976PMC
January 2019

Aripiprazole Elevated the Thyroid-Stimulating Hormone Level and is Associated With Hyperprolactinemia.

J Clin Psychopharmacol 2020 Jul/Aug;40(4):424-425

Kızıltepe State Hospital Child and Adolescent Psychiatry Mardin, Turkey Manisa Celal Bayar University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Manisa, Turkey.

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http://dx.doi.org/10.1097/JCP.0000000000001240DOI Listing

Erectile Dysfunction after Kidney Transplantation.

J Clin Med 2020 Jun 25;9(6). Epub 2020 Jun 25.

Department of Experimental and Clinical Medicine, Magna Graecia University Catanzaro, 88100 Catanzaro, Italy.

Patients with kidney transplantation often have a worse quality of life than the general population. One of the reasons for this, in male patients, is the high prevalence of erectile dysfunction. This is mainly due to the presence of comorbidities, surgery for kidney transplantation, adverse drug effects, psychological changes related to chronic disease, as well as hyperprolactinemia and hypogonadism. Read More

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http://dx.doi.org/10.3390/jcm9061991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356955PMC

Reduced dopaminergic tone during lactation is permissive to the hypothalamic stimulus for suckling-induced prolactin release.

J Neuroendocrinol 2020 Jun 9:e12880. Epub 2020 Jun 9.

Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Dopamine from tuberoinfundibular dopaminergic (TIDA) neurones tonically inhibits prolactin (PRL) secretion. Lactational hyperprolactinaemia is associated with a reduced activity of TIDA neurones. However, it remains controversial whether the suckling-induced PRL surge is driven by an additional decrease in dopamine release or by stimulation from a PRL-releasing factor. Read More

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http://dx.doi.org/10.1111/jne.12880DOI Listing

Editorial: Safety and Tolerability of Psychotropic Compounds.

Front Neurosci 2020 18;14:509. Epub 2020 Jun 18.

Department of Psychiatry, Hospital da Senhora da Oliveira Guimarães, Guimarães, Portugal.

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http://dx.doi.org/10.3389/fnins.2020.00509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314897PMC

Adenohypophyseal hyperfunction syndromes and posterior pituitary tumors: prevalence, clinical characteristics, and pathophysiological mechanisms.

Endocrine 2020 Jul 1. Epub 2020 Jul 1.

Departments of Endocrinology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.

Posterior pituitary tumors are rare nonneuroendocrine neoplasms originating in the neurohypophysis that lack hormonal secretory capacity. Surprisingly, these tumors are relatively frequently associated with adenohypophyseal syndromes of hormonal hypersecretion such as Cushing's disease and acromegaly. Fifteen cases of posterior pituitary tumor associated with hypercortisolism have been reported to date, 13 of them were pituicytomas (Pi) and 2 were granular cell tumors (GCT). Read More

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http://dx.doi.org/10.1007/s12020-020-02399-xDOI Listing

Evaluation of autoantibodies and immunoglobulin G subclasses in women with suspected macroprolactinemia.

J Clin Lab Anal 2020 Jun 29:e23456. Epub 2020 Jun 29.

Department of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

Background: Macroprolactin mostly composed of an immunoglobulin G (IgG) and a monomeric prolactin (PRL) represents the major circulating PRL form in the patients with macroprolactinemia that are usually asymptomatic and may not require treatment. In this study, we aimed to evaluate the prevalence of antithyroid and antinuclear antibodies, as well as the IgG subclass distributions in the patients suspected for macroprolactinemia.

Methods: From January to July in 2018, totally 317 patients with elevated PRL were subjected to the polyethylene glycol (PEG) precipitation assay. Read More

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http://dx.doi.org/10.1002/jcla.23456DOI Listing

Medical considerations in delusion of pregnancy: a systematic review.

J Psychosom Obstet Gynaecol 2020 Jun 29:1-7. Epub 2020 Jun 29.

Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA.

Delusions of pregnancy are associated with functional impairment and psychological distress. Previous works have focused on characterizing their etiology and identifying contributory social and cultural factors. The purpose of this review is to give an overview of the literature on medical or surgical comorbidities associated with delusions of pregnancy. Read More

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http://dx.doi.org/10.1080/0167482X.2020.1779696DOI Listing

Prolactin ordering patterns in psychiatric inpatients and the impact this has on patient management.

Australas Psychiatry 2020 Jun 25:1039856220934326. Epub 2020 Jun 25.

Department of Endocrinology & Diabetes, Alfred Hospital, Australia.

Objective: Guidelines stipulate that baseline prolactin be ordered prior to commencing antipsychotic treatment to facilitate investigation of any subsequent hyperprolactinaemic symptoms. The aim was to observe when and why prolactin levels are ordered for psychiatry inpatients commencing or continuing antipsychotics and how this alters clinical management.

Methods: Psychiatry inpatients admitted to the Alfred Hospital, Melbourne, Australia, in 2018 with the diagnoses of psychosis, schizophrenia, schizo-affective disorder or bipolar affective disorder were retrospectively analysed. Read More

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http://dx.doi.org/10.1177/1039856220934326DOI Listing

Transient hyperprolactinemia secondary to benzodiazepines: a case report.

Ann Biol Clin (Paris) 2020 Jun 22. Epub 2020 Jun 22.

Service de Biochimie et Génétique Moléculaire, CHU Hôpital G Montpied, Clermont-Ferrand, France.

Hyperprolactinemia is common and accounts for 20 to 25% of secondary amenorrhea causes. Here, we report a case of moderate hyperprolactinemia observed in a 40-year-old patient consulting for spaniomenorrhea and inguinal pain during a bartholinitis episode. After eliminating all known causes of hyperprolactinemia, alprazolam intake is finally assumed. Read More

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http://dx.doi.org/10.1684/abc.2020.1565DOI Listing

Proton Pump Inhibitor-Induced Galactorrhea in a Kidney Transplant Recipient: A Friend or Foe?

Case Rep Transplant 2020 13;2020:8108730. Epub 2020 May 13.

Department of Medicine, Division of Nephrology and Transplantation, University of Vermont Medical Center, Burlington, Vermont, USA.

Over the last decades, proton pump inhibitors (PPIs) have been widely used as the mainstay for treatment and prevention of gastrointestinal side effects, gastroesophageal reflux, and peptic ulcer disease. However, their safety profile has come into question recently after reports relating them to several side effects as well as kidney disease. Omeprazole, one of the mainly used PPIs, is almost entirely metabolized by the liver but the resulting metabolites are renally excreted. Read More

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http://dx.doi.org/10.1155/2020/8108730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254079PMC

Effect of α-1-adrenolytic agent and 5-α-reductase inhibitor on renal function in an experimental model of hyperprolactinemia-induced benign prostatic hyperplasia.

Pol Merkur Lekarski 2020 Jun;48(285):188-194

Experimental and Innovative Medicine Centre, University Centre of Veterinary Medicine, University of Agriculture in Krakow, Poland.

The standard pharmacotherapy of benign prostatic hyperplasia (BPH) may also alleviate potential kidney dysfunction resulting from the development of obstructive uropathy in the course of BPH.

Aim: The aim of study was to evaluate the effect of treatment with α-1- adrenolytic agent (tamsulosin) and 5-α-reductase inhibitor (finasteride) on renal function in rats.

Materials And Methods: Four groups of rats were studied: 1 - controls, 2 - rats with metoclopramide-induced hyperprolactinemia BPH model, 3 - rats with BPH treated with tamsulosin, 4 - rats with BPH treated with finasteride. Read More

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Rapid and Sustained Resolution of Risperidone Associated Hyperprolactinemia and Galactorrhea With Low-Dose Lurasidone.

J Clin Psychopharmacol 2020 Jul/Aug;40(4):410-412

Department of Psychiatry, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI Veterans Administration, San Francisco VA Health Care System, San Francisco, CA Department of Psychiatry, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI Veterans Administration, Spark M. Matsunaga VA Medical Center, Honolulu, HI Department of Psychiatry, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI.

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http://dx.doi.org/10.1097/JCP.0000000000001230DOI Listing

Macroprolactinemia in patients with hyperprolactinemia: an experience from a single tertiary center.

Pan Afr Med J 2020 6;36. Epub 2020 May 6.

Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Macroprolactinemia frequently causes misdiagnosis, unnecessary investigation and inappropriate treatment in hyperprolactinemic patients. Aim of this study is to investigate the prevalence and clinical characteristics of Thai patients with macroprolactinemia. We performed a cross-sectional study in 56 hyperprolactinemic patients (51 women and 5 men) whose sera were subsequently tested for the presence of macroprolactin. Read More

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http://dx.doi.org/10.11604/pamj.2020.36.8.22923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282613PMC

High biochemical recurrence rate after withdrawal of cabergoline in prolactinomas: is it necessary to restart treatment?

Endocrine 2020 Jun 17. Epub 2020 Jun 17.

UIM en Enfermedades Endócrinas, Hospital de Especialidades, UMAE Centro Médico Nacional Siglo XXI, IMSS, Ciudad de México, Mexico.

Purpose: Treatment with dopamine agonists (DA) is highly effective in patients with prolactinomas. In selected patients, discontinuation of DA after several years of successful treatment is possible, however, hyperprolactinemia recurs in 60-80% of them. It is unclear what is the clinical significance of these recurrences and hence, whether or not reinitiation of therapy is necessary. Read More

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http://dx.doi.org/10.1007/s12020-020-02388-0DOI Listing
June 2020
3.527 Impact Factor

A Remarkable Response of Granulomatous Hypophysitis to Infliximab in a Patient With a Background of Crohn's Disease-A Case Report.

Front Endocrinol (Lausanne) 2020 29;11:350. Epub 2020 May 29.

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, United States.

Hypophysitis is primary or idiopathic or secondary to another disease process. The histologic subtypes of hypophysitis are lymphocytic, granulomatous, xanthomatous, xanthogranulomatous, or IgG4-related. Granulomatous hypophysitis is the second most common form and is characterized by multinucleated giant cells with granulomas and histiocytes. Read More

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http://dx.doi.org/10.3389/fendo.2020.00350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272571PMC

Ovarian cyclicity and prolactin status of African elephants (Loxodonta africana) in North American zoos may be influenced by life experience and individual temperament.

Horm Behav 2020 Jul 10;125:104804. Epub 2020 Jul 10.

Center for Species Survival, Smithsonian Conservation Biology Institute, Front Royal, VA, USA.

Hyperprolactinemia is an endocrine disorder associated with infertility in many species, including elephants. In a recent survey of zoos accredited by the Association of Zoos and Aquariums (AZA), over half of African elephant females (N = 101) were not cycling normally, 30% of which exhibited hyperprolactinemia. We examined whether life experience and temperament predict ovarian cyclicity and circulating prolactin status in individual African elephant females. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2020.104804DOI Listing
July 2020
4.632 Impact Factor

SPONTANEOUS CEREBROSPINAL FLUID LEAK AFTER INITIATION OF DOPAMINE AGONIST THERAPY IN MACROPROLACTINOMAS: TWO CASE REPORTS AND A LITERATURE REVIEW.

AACE Clin Case Rep 2020 Mar-Apr;6(2):e90-e93. Epub 2020 Mar 4.

Objective: To describe 2 spontaneous cerebrospinal fluid (CSF) leaks complicating treatment of macroprolactinoma (MPRL) with dopamine agonist (DA) therapy.

Methods: We present the 2 cases of spontaneous, DA-related CSF leaks. Prolactin levels were used to assess hyperprolactinemia. Read More

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http://dx.doi.org/10.4158/AACR-2019-0372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282151PMC

Levosulpiride-induced Hyperprolactinemia.

J Coll Physicians Surg Pak 2020 04;30(4):457

Department of Endocrine, The Aga Khan University Hospital, Karachi, Pakistan.

Null. Read More

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http://dx.doi.org/10.29271/jcpsp.2020.04.457DOI Listing
April 2020
0.318 Impact Factor

Dopamine agonists and antipsychotics.

Authors:
Mark E Molitch

Eur J Endocrinol 2020 Sep;183(3):C11-C13

Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.

There can potentially be a number of clinical interactions that could adversely affect patient outcomes in a patient with a prolactinoma and psychiatric disease that might require antipsychotic and dopamine agonist treatment. Dopamine agonists stimulate the dopamine D2 receptor, resulting in a decrease in prolactin (PRL) levels and in prolactinoma size but action on dopamine receptors in the meso-limbic system may rarely cause psychosis and more commonly cause impulse control disorders. The psychiatric benefits of antipsychotic agents involve blocking the D2 and other dopamine receptors but this blockade often also causes hyperprolactinemia. Read More

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http://dx.doi.org/10.1530/EJE-20-0607DOI Listing
September 2020

Pharmacological treatment strategies for lowering prolactin in people with a psychotic disorder and hyperprolactinaemia: A systematic review and meta-analysis.

Schizophr Res 2020 Jun 2. Epub 2020 Jun 2.

Department of Mental Health, Hospital Universitari Parc Taulí, I3PT. Sabadell, Barcelona, Spain; Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Cerdanyola, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.

Different therapeutic strategies are used for lowering prolactin concentrations in patients with psychotic disorders with antipsychotic-induced hyperprolactinaemia. We aimed to examine the evidence from open-label studies and randomized clinical trials (RCTs) that studied four prolactin-lowering therapeutic strategies in people with psychotic disorders and hyperprolactinaemia: 1) switching to prolactin-sparing antipsychotics; 2) adding aripiprazole; 3) adding dopamine agonists; and 4) adding metformin. RCTs were included in a meta-analysis. Read More

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http://dx.doi.org/10.1016/j.schres.2020.04.031DOI Listing

Ectopic GH-secreting pituitary adenoma of the clivus: systematic literature review of a challenging tumour.

Pituitary 2020 Aug;23(4):457-466

Department of Neurosurgery, Ospedale "Vito Fazzi", Piazza F. Muratore, 1, 73100, Lecce, Italy.

Purpose: Acromegaly is usually due to growth hormone (GH)-secreting pituitary adenomas, but it may be exceptionally caused by GH-secreting ectopic pituitary adenomas (EPA). EPA are defined as extra-sellar pituitary tumours, extra- or intra-cranially sited, entirely separated from the pituitary stalk and gland. The aim of the study is to address the challenges in the management of clival GHEPA. Read More

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http://dx.doi.org/10.1007/s11102-020-01057-9DOI Listing
August 2020
2.222 Impact Factor

Clinical features and endoscopic findings of granular cell tumor of the sellar region: A case report and review of the literature.

Surg Neurol Int 2020 9;11:101. Epub 2020 May 9.

Departments of Neurosurgery, Ehime University School of Medicine, Shitsukawa, Toon, Ehime, Japan.

Background: Granular cell tumor (GCT) of the sellar region is a rare tumor of the sellar and suprasellar regions that originate from the neurohypophysis. This tumor is very difficult to differentiate from other pituitary neoplasms, such as pituitary adenoma, pituicytoma, and spindle cell oncocytoma. We report a rare case of GCT arising from the posterior pituitary of the sellar region and suggest a useful indicator for accurate diagnosis and pitfalls for surgical procedures. Read More

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http://dx.doi.org/10.25259/SNI_111_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265469PMC

Evidence On The New Drug Lumateperone (Iti-007) For Psychiatric And Neurological Disorders.

CNS Neurol Disord Drug Targets 2020 Jun 1. Epub 2020 Jun 1.

Institute of Psychiatry and Psychology, Department of Geriatrics, Neuroscience and Orthopedics, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome. Italy.

Lumateperone (ITI-007) is a tosylate salt with binding affinities to receptors implicated in the therapeutic actions of antipsychotic medications, including the serotonin 5HT2A receptors, dopamine D2 and D1 receptors and the serotonin transporter. It has a unique mechanism of action because it simultaneously modulates serotonin, dopamine, and glutamate neurotransmission, implicated in serious mental illness. It can be considered a multi-target-directed ligand and a multifunctional modulator of serotoninergic system with possible precognitive, antipsychotic, antidepressant and anxiolytic properties. Read More

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http://dx.doi.org/10.2174/1871527319666200601145653DOI Listing

The regulatory effect of bromocriptine on cardiac hypertrophy by prolactin and D2 receptor modulation.

Clin Exp Hypertens 2020 Oct 1;42(7):675-679. Epub 2020 Jun 1.

Sección de Estudios de Posgrado e Investigación, Escuela Superior De Medicina, Instituto Politécnico Nacional-Escuela Superior de Medicina , México City, México.

Background: Bromocriptine, a dopamine agonist, used for the treatment of hyperprolactinemia, type 2 diabetes, ovarian hyper-stimulation syndrome, has also effects on the cardiac remodeling process, but the mechanism of action is unknown. The aim of this work was to determinate the effect during hypertrophic process through molecular mechanisms that include prolactin receptor (Prlr) and receptor of dopamine 2 (D2 r) expression.

Methods: We used a model of cardiac hypertrophy induced by an aortocaval fistula (ACF) surgery in rats. Read More

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http://dx.doi.org/10.1080/10641963.2020.1772814DOI Listing
October 2020

Erectile dysfunction pre and post kidney transplant recipients in Duhok city; cross sectional study.

Ann Med Surg (Lond) 2020 Jul 16;55:107-110. Epub 2020 May 16.

Urologist, Duhok Directorate General of Health, Kurdistan Region, Iraq.

Introduction: Sexual dysfunction is a common problem in patients with chronic kidney disease. Disturbances in sexual function are noticed in early stages of chronic kidney diseases and deteriorate further as renal function declines. This is due to uremic effects, comorbid illness, anemia, hormonal disturbances, autonomic neuropathy, vascular diseases, hyperparathyroidism, hyperprolactinemia, side effects of medications, and psychosocial factors. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.04.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251300PMC

Mammary gland-specific regulation of GNRH and GNRH-receptor gene expression is likely part of a local autoregulatory system in female vizcachas (Rodentia: Chinchillidae).

Gen Comp Endocrinol 2020 Sep 29;296:113518. Epub 2020 May 29.

Centro de Estudios Biomédicos Básicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimónides, Ciudad Autónoma de Buenos Aires, Argentina(2); Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Electronic address:

In addition to key mammotrophic hormones such as the pituitary prolactin (PRL) and the ovarian steroids progesterone and estradiol, there are local factors that modulate the tissue dynamics of the mammary glands during pregnancy and lactation. By immunohistochemistry and RT-PCR, we found local transcription and translation of gonadotropin-releasing hormone (GNRH), GNRH receptor (GNRHR), PRL and PRL receptor (PRLR) in mammary glands of adult vizcachas during pregnancy and lactation. Both GNRH and GNRHR showed a lag between protein expression and gene transcription throughout the gestational period: while the highest transcription levels of these genes were recorded at early-pregnancy, the epithelial immunoexpressions of both showed their maximum during lactation. Read More

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http://dx.doi.org/10.1016/j.ygcen.2020.113518DOI Listing
September 2020

Macroprolactinemia Detection by Magnetically Assisted Polyethylene Glycol Precipitation: Potential for Automation.

J Appl Lab Med 2020 May;5(3):494-505

Department of Clinical Chemistry, Southend Hospital, Westcliff-on-Sea, Essex SSO ORY, UK.

Background: Macroprolactin is an immunoglobulin-prolactin complex that is not bioactive in vivo but the prolactin component remains immunoreactive. The complex is a universal source of interference in prolactin immunoassays and commonly results in misdiagnosis of hyperprolactinemia with consequent clinical mismanagement of patients. Removal of macroprolactin by precipitation with polyethylene glycol (PEG) is an effective technique for identifying such patients but unfortunately not universally employed due to the manual nature of the procedure. Read More

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http://dx.doi.org/10.1093/jalm/jfaa015DOI Listing

Recurrent Episodes of Paraphilic Behavior Possibly Associated With Olanzapine and Aripiprazole Treatment in a Patient With Schizophrenia.

Front Psychiatry 2020 20;11:318. Epub 2020 Apr 20.

Department of Psychiatry and Psychotherapy, Eberhard-Karls University of Tübingen, Tübingen, Germany.

Background: Hypersexual and paraphilic disorders have been frequently associated with concomitant psychiatric disorders, including schizophrenia. A growing number of published cases has recently indicated that hypersexual behavior may also arise in conjunction with treatment with second-generation antipsychotics. Although hypersexuality has been acknowledged as a possible side effect of antipsychotic treatment with partial dopamine agonists, including aripiprazole, only very few cases of olanzapine-associated hypersexuality have been reported in the literature. Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212450PMC

Methyldopa as an inductor of postpartum depression and maternal blues: A review.

Biomed Pharmacother 2020 Jul 12;127:110196. Epub 2020 May 12.

Department of Hepatobiliary and General Surgery, Faculty of Medicine Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.

Purpose: Pregnancy and time period right after labour are connected with some dangerous states, such as: pregnancy-induced hypertension (PIH), which afflict 6-10 % of pregnant women and mood disorders where postpartum depression occurs among 10-15 % of women after labour and so-called baby blues afflicts around 43 % of them. Scientists tried to link those diseases which afflicts thousands of women per year, and the linking factor appears to be methyldopa which is the first choice treatment of PIH. Recent study showed that 778 % of pregnant women treated with methyldopa suffered to postpartum depression. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110196DOI Listing

Primary amenorrhea in females attending gynaecological outpatient of a tertiary care hospital at Peshawar.

J Pak Med Assoc 2020 May;70(5):888-891

Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan.

Objective: To determine the aetiological factors of amenorrhea.

Methods: The pilot cross-sectional study was conducted in Government Naserullah Khan Babar Memorial Hospital, Peshawar, Pakistan, from January 2015 to December 2017, and comprised amenorrhea cases. Cases were analysed according to their clinical profile, ultrasound findings and biochemical tests. Read More

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http://dx.doi.org/10.5455/JPMA.24317DOI Listing
May 2020
0.403 Impact Factor

The pharmacogenetics of aripiprazole-induced hyperprolactinemia: what do we know?

Pharmacogenomics 2020 06 13;21(9):571-574. Epub 2020 May 13.

Clinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, 28006, Spain.

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http://dx.doi.org/10.2217/pgs-2020-0024DOI Listing

Prevalence and risk factors of hypogonadism in men with chronic renal failure.

Tunis Med 2020 Feb;98(2):138-143

Aim: To determine the prevalence and the risk factors of hypogonadism in men with chronic renal failure (CRF).

Methods: We conducted a cross sectional analysis in 48 men with CRF. Total testosterone, prolactin, and gonadotropins were measured in all patients. Read More

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February 2020

Association of ANKK1 polymorphism with antipsychotic-induced hyperprolactinemia.

Hum Psychopharmacol 2020 Jul 8;35(4):e2737. Epub 2020 May 8.

Mental Health Research Institute, Tomsk National Research Medical Center of Russian Academy of Sciences, Tomsk, Russia.

Objective: Schizophrenia is a severe highly heritable mental disorder. Genetic polymorphisms of dopaminergic pathways are related to pathogenesis of drug response. Hyperprolactinemia (HPRL), a common adverse effect of antipsychotics, is attributed to blockade of dopamine D2 receptors. Read More

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http://dx.doi.org/10.1002/hup.2737DOI Listing

ADRENAL INCIDENTALOMA, BREAST CANCER AND UNRECOGNIZED MULTIPLE ENDOCRINE NEOPLASIA TYPE 1.

Authors:
S H Kim J H Park

Acta Endocrinol (Buchar) 2019 Oct-Dec;15(4):513-517

Jeonbuk National University Medical School - Department of Internal Medicine, Jeonju, Republic of Korea.

Background: The incidence of adrenal incidentaloma has been increasing proportional to the use of radiologic examination. Multiple endocrine neoplasia1 (MEN1) syndrome may present with various tumors. The present study reports a case of adrenal incidentaloma with unrecognised MEN1 syndrome associated with breast cancer. Read More

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http://dx.doi.org/10.4183/aeb.2019.513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200108PMC

Primary sellar neuroblastoma mimicking invasive pituitary adenoma: a systematic review.

J Neurosurg Sci 2020 Aug 29;64(4):377-382. Epub 2020 Apr 29.

Department of Neurosurgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

Introduction: To report an extremely rare case of sellar neuroblastoma, which mimicked invasive pituitary adenoma with supra- and parasellar extensions, treated through endoscopic endonasal approach. A systematic review of the literature on diagnosis and management of patients affected by sellar neuroblastomas has been performed.

Evidence Acquiition: A literature search according to the PRISMA statement was conducted using MEDLINE, Google Scholar, and EBSCO databases, searching for the following MeSH terms: (sellar OR parasellar OR suprasellar OR sphenoidal) AND (neuroblastoma OR extranasal esthesioneuroblastoma OR central neuroblastoma). Read More

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http://dx.doi.org/10.23736/S0390-5616.20.04931-0DOI Listing

138 Efficacy and Safety of SEP-363856, a Novel Psychotropic Agent with a Non-D2 Mechanism of Action, in the Treatment of Schizophrenia.

CNS Spectr 2020 Apr;25(2):287-288

Sunovion Pharmaceuticals Inc., Marlborough, MA, USA.

Background: SEP-363856 is a novel psychotropic agent that has shown broad efficacy in animal models of schizophrenia and depression. Its antipsychotic effects appear to be mediated by agonist activity at both trace amine-associated receptor 1 (TAAR1) and 5-HT1A receptors. Notably, SEP-363856 does not bind to any dopaminergic, serotonergic (except 5-HT1A), glutamatergic, or other neuroreceptors thought to mediate the effects of currently available antipsychotics. Read More

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http://dx.doi.org/10.1017/S1092852920000541DOI Listing

Ectopic Prolactin Secretion From a Uterine Leiomyoma.

J Endocr Soc 2020 Apr 16;4(4):bvaa035. Epub 2020 Mar 16.

Division of Endocrinology, Diabetes and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Ectopic hormone production is well recognized, but ectopic production of prolactin has been reported infrequently. We report here the case of a 47-year-old woman who had hyperprolactinemia (213-224 ng/mL) causing galactorrhea and hypogonadism. Cabergoline treatment, 1. Read More

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http://dx.doi.org/10.1210/jendso/bvaa035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145276PMC