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    Phosphate imbalance in patients with heart failure.
    Heart Fail Rev 2017 Apr 22. Epub 2017 Apr 22.
    Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10, Ioannina, Greece.
    Patients with heart failure often exhibit electrolyte abnormalities, such as hyponatremia or hypokalemia/hyperkalemia. Although not as common as the other electrolyte disturbances observed in patients with heart failure, phosphate imbalance is also of high importance in this population. The aim of this review is to present the mechanisms of low or high phosphate serum levels in patients with heart failure and its role in the pathogenesis and progression of heart dysfunction. Read More

    Idiopathic hypoparathyroidism with extensive intracranial calcification in children: First report from Saudi Arabia.
    Medicine (Baltimore) 2017 Apr;96(16):e6347
    aPediatric Hepatologist, Faculty of Medicine, Cairo University, Cairo, Egypt. Pediatric Hepatologist, Alhada Armed Forces Hospital, Taif, KSA bPediatric endocrinologist, Armed Forces Hospitals of Taif Region, Taif, KSA cPediatric neonatologist, Alhada Armed Forces Hospital, Taif, KSA dPediatric endocrinologist, Alhada Armed Forces Hospital, Taif, KSA ePediatrics, Children Hospital, Taif, KSA fPediatric Allergist and immunologist Alhada Armed Forces Hospital, Taif, KSA gPediatric Nephrologist, College of Medicine, Taif University, Taif, KSA hMedical intern, Taif University, Taif, KSA iPediatric Hematologist and Oncologist, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    Rationale: Pediatric idiopathic hypoparathyroidism with extensive intracranial calcifications outside the basal ganglia (BG) is extremely rare with less than 10 cases worldwide.

    Patient Concerns: An 11-year-old Saudi male child presented with tetany with otherwise normal neurological and other body system examination diagnoses severe hypocalcemia for differential diagnosis.

    Interventions: Further investigations revealed hyperphosphatemia and undetectable serum intact parathyroid hormone. Read More

    Fibroblast Growth Factor-23 Concentration in Dogs with Chronic Kidney Disease.
    J Vet Intern Med 2017 Apr 17. Epub 2017 Apr 17.
    Veterinary Clinical Sciences, The Ohio State University, Columbus, OH.
    Background: Chronic kidney disease (CKD) is associated with hyperphosphatemia, decreased vitamin D metabolite concentrations, and hyperparathyroidism. This syndrome is known as CKD-mineral bone disorder (CKD-MBD). Recently, it has been shown that an increase in fibroblast growth factor-23 (FGF-23) concentration is an early biomarker of CKD in people. Read More

    Effectiveness of educational or behavioral interventions on adherence to phosphate control in adults receiving hemodialysis: a systematic review.
    JBI Database System Rev Implement Rep 2017 Apr;15(4):971-1010
    1School of Nursing, Queensland University of Technology, Brisbane, Australia 2Renal Nursing Professorial Unit, Kidney Health Services, Royal Brisbane and Women's Hospital, Brisbane, Australia 3CEBHA (Centre for Evidence-Based Healthy Ageing): a Joanna Briggs Institute Centre of Excellence.
    Background: People with end-stage kidney disease (ESKD) develop impaired excretion of phosphate. Hyperphosphatemia develops in ESKD as a result of the kidney's reduced ability to excrete ingested phosphate load and is characterized by high bone turnover and increased musculoskeletal morbidity including bone pain and muscle weakness. Increased serum phosphate levels are also associated with cardiovascular disease and associated mortality. Read More

    The Diet and Haemodialysis Dyad: Three Eras, Four Open Questions and Four Paradoxes. A Narrative Review, Towards a Personalized, Patient-Centered Approach.
    Nutrients 2017 Apr 10;9(4). Epub 2017 Apr 10.
    Nefrologia, Università di Pisa, 56100 Italy.
    The history of dialysis and diet can be viewed as a series of battles waged against potential threats to patients' lives. In the early years of dialysis, potassium was identified as "the killer", and the lists patients were given of forbidden foods included most plant-derived nourishment. As soon as dialysis became more efficient and survival increased, hyperphosphatemia, was identified as the enemy, generating an even longer list of banned aliments. Read More

    Basal Ganglia Calcification with Tetanic Seizure Suggest Mitochondrial Disorder.
    Am J Case Rep 2017 Apr 9;18:375-380. Epub 2017 Apr 9.
    Department of Radiology, Krankenanstalt Rudolfstiftung, Vienna, Austria.
    BACKGROUND Basal ganglia calcification (BGC) is a rare sporadic or hereditary central nervous system (CNS) abnormality, characterized by symmetric or asymmetric calcification of the basal ganglia. CASE REPORT We report the case of a 65-year-old Gypsy female who was admitted for a tetanic seizure, and who had a history of polyneuropathy, restless-leg syndrome, retinopathy, diabetes, hyperlipidemia, osteoporosis with consecutive hyperkyphosis, cervicalgia, lumbalgia, struma nodosa requiring thyroidectomy and consecutive hypothyroidism, adipositas, resection of a vocal chord polyp, arterial hypertension, coronary heart disease, atheromatosis of the aorta, peripheral artery disease, chronic obstructive pulmonary disease, steatosis hepatis, mild renal insufficiency, long-term hypocalcemia, hyperphosphatemia, impingement syndrome, spondylarthrosis of the lumbar spine, and hysterectomy. History and clinical presentation suggested a mitochondrial defect which also manifested as hypoparathyroidism or Fanconi syndrome resulting in BGC. Read More

    Safety and Efficacy of Treatment with Asfotase Alfa in Patients with Hypophosphatasia: Results from a Japanese Clinical Trial.
    Clin Endocrinol (Oxf) 2017 Apr 4. Epub 2017 Apr 4.
    Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.
    Objective: Hypophosphatasia (HPP) is a rare skeletal disease characterized by hypomineralization and low alkaline phosphatase activity. Asfotase alfa (AA) has been recently developed to treat HPP complications. This study evaluated its safety and efficacy in Japan. Read More

    Availability of 24-h urine collection method on dietary phosphorus intake estimation.
    J Clin Biochem Nutr 2017 Mar 6;60(2):125-129. Epub 2016 Dec 6.
    Laboratory of Clinical Nutrition and Management, Graduate School of Nutritional and Environmental Sciences, The University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
    Accurate assessment of dietary phosphorus intake is necessary to prevent hyperphosphatemia. The aim of this study was to evaluate the 24-h urine collection method for estimation of phosphate intake in healthy males. Two experiments, a 1-day and a 5-day loading test, were performed. Read More

    Novel phosphate-activated macrophages prevent ectopic calcification by increasing extracellular ATP and pyrophosphate.
    PLoS One 2017 31;12(3):e0174998. Epub 2017 Mar 31.
    Centro Nacional de Investigaciones CardiovascularesCarlos III (CNIC), Madrid, Spain.
    Purpose: Phosphorus is an essential nutrient involved in many pathobiological processes. Less than 1% of phosphorus is found in extracellular fluids as inorganic phosphate ion (Pi) in solution. High serum Pi level promotes ectopic calcification in many tissues, including blood vessels. Read More

    Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation.
    J Vis Exp 2017 Mar 14(121). Epub 2017 Mar 14.
    Endocrine Unit, Massachusetts General Hospital, Harvard Medical School;
    Hypoparathyroidism (HP) is a disorder characterized by low levels of PTH which lead to hypocalcemia, hyperphosphatemia, and low bone turnover. The most common cause of the disease is accidental removal of the parathyroid glands during thyroid surgery. Novel therapies for HP are needed, but testing them requires reliable animal models of acquired HP. Read More

    In-Center Nocturnal Hemodialysis Versus Conventional Hemodialysis: A Systematic Review of the Evidence.
    Am J Kidney Dis 2017 Mar 27. Epub 2017 Mar 27.
    Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, AB, Canada.
    Background: Owing to its longer treatment duration-up to 8 hours per dialysis treatment-in-center thrice-weekly nocturnal hemodialysis (HD) is receiving greater attention. To better understand the evidence for in-center nocturnal HD, we sought to systematically review the literature to determine the effects of in-center nocturnal HD versus conventional HD on clinically relevant outcomes.

    Study Design: We searched MEDLINE, Embase, Evidence-Based Medicine Reviews (EBMR), Web of Science, and Scopus from the earliest date in the database to November 2016. Read More

    Comparative study of obstructive urolithiasis and its sequelae in buffalo calves.
    Vet World 2017 Feb 8;10(2):156-162. Epub 2017 Feb 8.
    Department of Animal Medicine (Internal Medicine), Faculty of Veterinary Medicine, Zagazig University, Egypt.
    Aim: The present work was designed to study the incidence of obstructive urolithiasis and to apply comparative diagnosis to urine retention cases.

    Materials And Methods: A total of 78 non-castrated buffalo calves aging 3-11 months were included in this study, 68 calves were admitted to the Veterinary Teaching Hospital, Zagazig University, Egypt, during the study period with a history of anuria, and they were classified into three groups; intact bladder group (19 calves), uroperitoneum group (45 calves), and ruptured urethra group (4 calves). 10 apparently healthy calves were used for comparison. Read More

    Progressive development of PTH resistance in patients with inactivating mutations on the maternal allele of GNAS.
    J Clin Endocrinol Metab 2017 Feb 21. Epub 2017 Feb 21.
    APHP, Reference center for Rare Disorders of the Mineral Metabolism and Plateforme d'Expertise Paris Sud Maladies Rares, Bicêtre Paris Sud Hospital, Le Kremlin Bicêtre, France.
    Background: PTH resistance is characterized by hypocalcaemia, hyperphosphatemia and elevated PTH in absence of vitamin D deficiency. Pseudohypoparathyroidism (PHP) type 1A (or iPPSD2, inactivating Signaling PTH/PTHrp Disorder 2 according to the new classification) is caused by mutations in the maternal GNAS allele.

    Objective: To assess PTH resistance over time in 20 patients affected by iPPSD2 (PHP1A), diagnosed because of family history, ectopic ossification or short stature and carrying a GNAS mutation. Read More

    Effect of stage-based education provided by dedicated dietitians on hyperphosphataemic haemodialysis patients: results from the Nutrition Education for Management of Osteodystrophy randomised controlled trial.
    J Hum Nutr Diet 2017 Mar 21. Epub 2017 Mar 21.
    Department of Health Services Research, CAPHRI School of Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands.
    Background: The Nutrition Education for Management of Osteodystrophy trial showed that stage-based nutrition education by dedicated dietitians surpasses existing practices in Lebanon with respect to lowering serum phosphorus among general haemodialysis patients. The present study explores the effect of nutrition education specifically on hyperphosphataemic patients from this trial.

    Methods: Hyperphosphataemic haemodialysis patients were allocated to a dedicated dietitian (DD), a trained hospital dietitian (THD) and existing practice (EP) protocols. Read More

    Hyperphosphatemia and hs-CRP Initiate the Coronary Artery Calcification in Peritoneal Dialysis Patients.
    Biomed Res Int 2017 22;2017:2520510. Epub 2017 Feb 22.
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai 200040, China.
    Background. Coronary artery calcification (CAC) contributes to high risk of cardiocerebrovascular diseases in dialysis patients. However, the risk factors for CAC initiation in peritoneal dialysis (PD) patients are not known clearly. Read More

    Effects of Tenapanor on Cytochrome P450-Mediated Drug-Drug Interactions.
    Clin Pharmacol Drug Dev 2017 Mar 16. Epub 2017 Mar 16.
    AstraZeneca Gothenburg, Mölndal, Sweden.
    Tenapanor (RDX5791, AZD1722) is an inhibitor of sodium/hydrogen exchanger isoform 3 in development for the treatment of constipation-predominant irritable bowel syndrome and the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis. We aimed to investigate whether tenapanor inhibits or induces cytochrome P450s (CYPs). In vitro experiments assessing the potential of tenapanor to affect various CYPs indicated that it could inhibit CYP3A4/5 (IC50 0. Read More

    Clinical Epidemiology of Mineral Bone Disorder Markers in Prevalent Hemodialysis Patients in the Xinjiang Uyghur Autonomous Region in China.
    Biomed Res Int 2017 19;2017:2516934. Epub 2017 Feb 19.
    Department of Nephrology, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, China.
    We investigated the clinical epidemiology of mineral bone disorder markers in prevalent hemodialysis (HD) patients in Xinjiang, the largest province in China. Data were obtained from 59 hospitals. A total of 3725 patients tracked from January 1 to December 31, 2014, were enrolled. Read More

    Phosphorus Regulation in Chronic Kidney Disease.
    Methodist Debakey Cardiovasc J 2016 Oct-Dec;12(4 Suppl):6-9
    Houston Methodist Hospital, Houston, Texas.
    Serum phosphorus levels stay relatively constant through the influence of multiple factors-such as parathyroid hormone, fibroblast growth factor 23, and vitamin D-on the kidney, bone, and digestive system. Whereas normal serum phosphorus ranges between 3 mg/dL to 4.5 mg/dL, large cross-sectional studies have shown that even people with normal kidney function are sometimes found to have levels ranging between 1. Read More

    Pseudohypoparathyroidism with basal ganglia calcification: A case report of rare cause of reversible parkinsonism.
    Medicine (Baltimore) 2017 Mar;96(11):e6312
    Department of Neurology, Qilu Hospital of Shandong University, Jinan, China.
    Rationale: Parkinsonism can be secondary to many internal diseases, in some certain conditions, it seems that the clinical manifestations of parkinsonism presenting reversible. We report a case of patient with parkinsonism secondary to pseudohypoparathyroidism, who improved markedly after the supplement of serum calcium.

    Patient Concerns And Diagnoses: A 52-year-old woman with acute parkinsonism was diagnosed as pseudohypoparathyroidism after the conducting of brain computed tomography, laboratory examinations, and gene detection. Read More

    Antibody-mediated inhibition of EGFR reduces phosphate excretion and induces hyperphosphatemia and mild hypomagnesemia in mice.
    Physiol Rep 2017 Mar;5(5)
    Department of Biology, The College at Brockport State University of New York, Brockport, New York.
    Monoclonal antibody therapies targeting the EGF receptor (EGFR) frequently result in hypomagnesemia in human patients. In contrast, EGFR tyrosine kinase inhibitors do not affect Mg(2+) balance in patients and only have a mild effect on Mg(2+) homeostasis in rodents at elevated doses. EGF has also been shown to affect phosphate (Pi) transport in rat and rabbit proximal convoluted tubules (PCT), but evidence from studies targeting EGFR and looking at Pi excretion in whole animals is still missing. Read More

    Trends of Serum Electrolyte Changes in Crush syndrome patients of Bam Earthquake; a Cross sectional Study.
    Emerg (Tehran) 2017 8;5(1):e7. Epub 2017 Jan 8.
    Emergency Department, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Teharn, Iran.
    Introduction: Electrolyte imbalances are very common among crushed earthquake victims but there is not enough data regarding their trend of changes. The present study was designed to evaluate the trend of changes in sodium, calcium, and phosphorus ions among crush syndrome patients.

    Methods: In this retrospective cross-sectional study, using the database of Bam earthquake victims, which was developed by Iranian Society of Nephrology following Bam earthquake, Iran, 2003, the 10-day trend of sodium, calcium, and phosphorus ions changes in > 15 years old crush syndrome patients was evaluated. Read More

    Herbal and dietary supplements related to diarrhea and acute kidney injury: a case report.
    J Complement Integr Med 2017 Mar;14(1)
    Background There is very little evidence relating to the association of herbal medicine with diarrhea and the development of acute kidney injury (AKI). This study reports a case of diarrhea-induced AKI, possibly related to an individual ingesting copious amounts of homemade mixed fruit and herb puree. Case presentation A 45-year-old Thai man with diabetes had diarrhea for 2 days, as a result of taking high amounts of a puree made up of eight mixed fruits and herbs over a 3-day period. Read More

    Hypophosphatemia: nutritional status, body composition, and mortality in hemodialysis patients.
    Int Urol Nephrol 2017 Mar 6. Epub 2017 Mar 6.
    Nephrocare, Faro, Portugal.
    Purpose: The aim of the present study was to investigate the relationship between serum phosphate levels, clinical parameters, body composition, and mortality.

    Methods: Multicenter longitudinal observational study of a cohort of 3552 patients in hemodialysis (HD) from 34 Nephrocare dialysis units in Portugal with 24 months of follow-up. Patients were divided into three groups depending on their serum phosphorus (<3. Read More

    Lanthanum Deposition in the Stomach: Usefulness of Scanning Electron Microscopy for Its Detection.
    Acta Med Okayama 2017 Feb;71(1):73-78
    Departments of Gastroenterology and Hepatology, General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558,
    After having been treated with lanthanum carbonate administration for 4 years for hyperphosphatemia, a 75-year-old Japanese woman undergoing hemodialysis was diagnosed with lanthanum phosphate deposition in the stomach. The deposition, seen as white microgranules, was observed using esophagogastroduodenoscopy with magnifying observation. To the best of our knowledge, these are the minutest endoscopy images of lanthanum phosphate deposition in the gastric mucosa. Read More

    Educational nursing intervention to reduce the hyperphosphatemia in patients on hemodialysis.
    Rev Bras Enferm 2017 Jan-Feb;70(1):31-38
    Universidade Federal de São Paulo, Escola Paulista de Enfermagem, Departamento de Enfermagem. São Paulo-SP, Brasil.
    Objective:: to evaluate the effectiveness of an educational nursing intervention to reduce hyperphosphataemia in chronic renal patients on hemodialysis.

    Method:: quasi-experimental study with 63 hyperphosphatemic patients on hemodialysis. The intervention consisted of developing and providing a printed and illustrated manual to patients containing information on disease control. Read More

    Diabetes Mellitus and Younger Age Are Risk Factors for Hyperphosphatemia in Peritoneal Dialysis Patients.
    Nutrients 2017 Feb 17;9(2). Epub 2017 Feb 17.
    Department of Medicine, Division of Nephrology, Ottawa Hospital, University of Ottawa, Kidney Research Centre, Ottawa Hospital Research Institute, Ottawa, ON K1H 7W9, Canada.
    Hyperphosphatemia has been associated with adverse outcomes in patients with end stage kidney disease (ESKD). The purpose of this study was to determine risk factors for hyperphosphatemia in ESKD patients treated with peritoneal dialysis (PD). This information will be used to develop a patient specific phosphate binder application to facilitate patient self-management of serum phosphate. Read More

    Prevention and treatment of tumor lysis syndrome, and the efficacy and role of rasburicase.
    Onco Targets Ther 2017 2;10:597-605. Epub 2017 Feb 2.
    Department of Internal Medicine I, University Hospital Carl Gustav Carus at the Technische Universitaet Dresden, Dresden.
    Tumor lysis syndrome (TLS) is a potentially life-threatening condition that occurs in oncologic and hematologic patients with large tumor burden, either due to cytotoxic therapy or, less commonly, spontaneously because of massive tumor cell lysis. TLS is clinically characterized by acute renal failure, hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. While limited options are available for treating TLS, identifying patients at high risk for developing TLS and prevention in high-risk patients remain an important aspect in the treatment of cancer patients. Read More

    Long-Term Safety and Efficacy of Bixalomer in Hyperphosphatemic Patients With Chronic Kidney Disease Not on Dialysis.
    Ther Apher Dial 2017 Apr 14;21(2):173-179. Epub 2017 Feb 14.
    Global Development, Astellas Pharma Inc., Tokyo, Japan.
    Bixalomer, a metal-free, nonabsorbable phosphate binder, is approved in Japan to treat hyperphosphatemia in dialysis patients. Bixalomer is effective and has a favorable safety profile in predialysis patients with hyperphosphatemia. This study examined the long-term effectiveness and safety of bixalomer in predialysis patients with hyperphosphatemia. Read More

    [Diagnosis and treatment of chronic kidney disease].
    Internist (Berl) 2017 Mar;58(3):243-256
    Klinik für Innere Medizin II, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle (Saale), Deutschland.
    Chronic kidney disease is defined by decreased glomerular filtration rate or proteinuria. Diabetic nephropathy and hypertensive renal damage are responsible for the majority of cases. The initiation of therapy has to consider if causal treatment of the underlying disease is possible and indicated. Read More

    Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors.
    JCI Insight 2017 Feb 9;2(3):e91079. Epub 2017 Feb 9.
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    Heterotrimeric G proteins play critical roles in transducing extracellular signals generated by 7-transmembrane domain receptors. Somatic gain-of-function mutations in G protein α subunits are associated with a variety of diseases. Recently, we identified gain-of-function mutations in Gα11 in patients with autosomal-dominant hypocalcemia type 2 (ADH2), an inherited disorder of hypocalcemia, low parathyroid hormone (PTH), and hyperphosphatemia. Read More

    The Daily Consumption of Cola Can Determine Hypocalcemia: A Case Report of Postsurgical Hypoparathyroidism-Related Hypocalcemia Refractory to Supplemental Therapy with High Doses of Oral Calcium.
    Front Endocrinol (Lausanne) 2017 26;8. Epub 2017 Jan 26.
    Biomedical Department of Internal and Specialist Medicine (DIBIMIS), Section of Endocrine-Metabolic Diseases, University of Palermo , Palermo , Italy.
    The consumption of soft drinks is a crucial factor in determining persistent hypocalcemia. The aim of the study is to evaluate the biochemical mechanisms inducing hypocalcemia in a female patient with usual high consumption of cola drink and persistent hypocalcemia, who failed to respond to high doses of calcium and calcitriol supplementation. At baseline and after pentagastrin injection, gastric secretion (Gs) and duodenal secretion (Ds) samples were collected and calcium and total phosphorus (Ptot) concentrations were evaluated. Read More

    Klotho expression in long bones regulates FGF23 production during renal failure.
    FASEB J 2017 Feb 9. Epub 2017 Feb 9.
    Division of Bone and Mineral Research, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA;
    Circulating levels of bone-derived fibroblast growth factor 23 (FGF23) increase early during acute and chronic kidney disease and are associated with adverse outcomes. Membrane-bound Klotho acts as a permissive coreceptor for FGF23, and its expression was recently found in osteoblasts/osteocytes. We hypothesized that Klotho in bone cells is part of an autocrine feedback loop that regulates FGF23 expression during renal failure. Read More

    Elemental calcium intake associated with calcium acetate/calcium carbonate in the treatment of hyperphosphatemia.
    Drugs Context 2017 20;6:212302. Epub 2017 Jan 20.
    Shire Pharmaceuticals, Lexington, MA, USA.
    Background: Calcium-based and non-calcium-based phosphate binders have similar efficacy in the treatment of hyperphosphatemia; however, calcium-based binders may be associated with hypercalcemia, vascular calcification, and adynamic bone disease.

    Scope: A post hoc analysis was carried out of data from a 16-week, Phase IV study of patients with end-stage renal disease (ESRD) who switched to lanthanum carbonate monotherapy from baseline calcium acetate/calcium carbonate monotherapy. Of the intent-to-treat population (N=2520), 752 patients with recorded dose data for calcium acetate (n=551)/calcium carbonate (n=201) at baseline and lanthanum carbonate at week 16 were studied. Read More

    Effects of Magnesium on the Phosphate Toxicity in Chronic Kidney Disease: Time for Intervention Studies.
    Nutrients 2017 Feb 6;9(2). Epub 2017 Feb 6.
    Department of Nephrology, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita 565-0871, Japan.
    Magnesium, an essential mineral for human health, plays a pivotal role in the cardiovascular system. Epidemiological studies in the general population have found an association between lower dietary magnesium intake and an elevated risk of cardiovascular events. In addition, magnesium supplementation was shown to improve blood pressure control, insulin sensitivity, and endothelial function. Read More

    Association of Serum Phosphorus Concentration with Mortality and Graft Failure among Kidney Transplant Recipients.
    Clin J Am Soc Nephrol 2017 Apr 3;12(4):653-662. Epub 2017 Feb 3.
    Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, and
    Background And Objectives: Hyperphosphatemia in kidney transplant recipients has been shown to predict poorer graft and patient survival. However, studies examining hypophosphatemia are scarce.

    Design, Setting, Participants, & Measurements: To evaluate the association of serum phosphorus level with patient and graft survival, we performed a retrospective multicenter cohort study. Read More

    Effect of Tenapanor on Serum Phosphate in Patients Receiving Hemodialysis.
    J Am Soc Nephrol 2017 Feb 3. Epub 2017 Feb 3.
    Division of Nephrology, Stanford University School of Medicine, Stanford, California.
    Hyperphosphatemia is common among patients with CKD stage 5D and is associated with morbidity and mortality. Current guidelines recommend lowering serum phosphate concentrations toward normal. Tenapanor is a minimally absorbed small molecule inhibitor of the sodium/hydrogen exchanger isoform 3 that functions in the gut to reduce sodium and phosphate absorption. Read More

    Heritable and acquired disorders of phosphate metabolism: Etiologies involving FGF23 and current therapeutics.
    Bone 2017 Jan 31. Epub 2017 Jan 31.
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:
    Phosphate is critical for many cellular processes and structural functions, including as a key molecule for nucleic acid synthesis and energy metabolism, as well as hydroxyapatite formation in bone. Therefore it is critical to maintain tight regulation of systemic phosphate levels. Based upon its broad biological importance, disruption of normal phosphate homeostasis has detrimental effects on skeletal integrity and overall health. Read More

    [Role of fibroblast growth factor 23 in the development of cardiovascular diseases in patients with end-stage renal failure on programmed hemodialysis].
    Ter Arkh 2016 ;88(12):51-56
    North Ossetian State Medical Academy, Ministry of Health of Russia, Vladikavkaz, Russia.
    Aim: To determine the nature of changes in fibroblast growth factor 23 (FGF-23) and other bone mineral metabolism parameters detectable in the blood of patients with end-stage chronic renal failure (CRF) and to analyze their links to the development of cardiovascular events in uremic intoxication.

    Subjects And Methods: A total of 75 patients (45 men and 30 women) aged 23 to 66 years (mean age, 53±2.1 years) with Stage VD CKF were examined. Read More

    Fibroblast Growth Factor 23-Mediated Bone Disease.
    Endocrinol Metab Clin North Am 2017 Mar 14;46(1):19-39. Epub 2016 Dec 14.
    Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:
    Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. This article reviews the FGF23-α-Klotho signaling pathway, highlighting the latest developments in FGF23 regulation and action, and describes the disorders associated with FGF23 excess or deficiency. Read More

    Immune-Mediated Muscle Diseases of the Horse.
    Vet Pathol 2017 Jan 1:300985816688755. Epub 2017 Jan 1.
    2 Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI, USA.
    In horses, immune-mediated muscle disorders can arise from an overzealous immune response to concurrent infections or potentially from an inherent immune response to host muscle antigens. Streptococcus equi ss. equi infection or vaccination can result in infarctive purpura hemorrhagica (IPH) in which vascular deposition of IgA-streptococcal M protein complexes produces ischemia and complete focal infarction of skeletal muscle and internal organs. Read More

    Diet in chronic kidney disease in a Mediterranean African country.
    BMC Nephrol 2017 Jan 23;18(1):34. Epub 2017 Jan 23.
    Neprology Department Hedi Chaker Hospital, Sfax, Tunisia.
    Background: Mediterranean diet is characterized by low to moderate consumption of animal protein and high consumption of fruits, vegetables, bread, beans, nuts, seeds and other cereals. It has been associated with reduced risk of cardiovascular disease. However, it is not suitable for chronic kidney disease because of high potassium intake. Read More

    Giving Calcification Its Due: Recognition of a Diverse Disease: A First Attempt to Standardize the Field.
    Circ Res 2017 Jan;120(2):270-273
    From the Center for Interdisciplinary Cardiovascular Sciences (J.D.H., M.C.B., E.A.) and Center for Excellence in Vascular Biology, Cardiovascular Division (E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston; and Department of Biomedical Engineering, Florida International University, Miami (J.D.H.).

    J Fam Pract 2016 Nov;65(11):754-756
    The Department of Pharmacotherapy, University of Utah College of Pharmacy and the Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
    The article incorrectly stated: "Elevations of both fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) lead to hyperphosphatemia and hypocalcemia because of decreased urinary excretion of phosphorus." In fact, FGF23 normally acts to lower blood phosphate levels. Furthermore, an elevated phosphorus level causes an increase in serum calcium levels and not hypocalcemia. Read More

    A Large Inversion Involving GNAS Exon A/B and All Exons Encoding Gsα Is Associated With Autosomal Dominant Pseudohypoparathyroidism Type Ib (PHP1B).
    J Bone Miner Res 2017 Apr 24;32(4):776-783. Epub 2017 Feb 24.
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
    Pseudohypoparathyroidism type Ib (PHP1B) is characterized primarily by resistance to parathyroid hormone (PTH) and thus hypocalcemia and hyperphosphatemia, in most cases without evidence for Albright hereditary osteodystrophy (AHO). PHP1B is associated with epigenetic changes at one or several differentially-methylated regions (DMRs) within GNAS, which encodes the α-subunit of the stimulatory G protein (Gsα) and splice variants thereof. Heterozygous, maternally inherited STX16 or GNAS deletions leading to isolated loss-of-methylation (LOM) at exon A/B alone or at all maternal DMRs are the cause of autosomal dominant PHP1B (AD-PHP1B). Read More

    Net Budgetary Impact of Ferric Citrate as a First-Line Phosphate Binder for the Treatment of Hyperphosphatemia: A Markov Microsimulation Model.
    Drugs R D 2017 Mar;17(1):159-166
    Stanford University School of Medicine, Palo Alto, CA, USA.
    Ferric citrate (FC) has demonstrated efficacy as a phosphate binder and reduces the requirements for erythropoiesis-stimulating agents (ESAs) and intravenous (IV) iron in dialysis patients. We developed a net budgetary impact model to evaluate FC vs. other phosphate binders from the vantage of a large dialysis provider. Read More

    Phosphate Binders and Targets Over Decades: Do We have it Right Now?
    Semin Dial 2017 Mar 8;30(2):134-141. Epub 2017 Jan 8.
    Division of Renal Diseases, Hypertension University of Colorado, Denver, Colorado.
    In advanced renal disease, the kidney is unable to maintain phosphate balance due to decreased urinary excretion as well as the imbalance of the bone metabolic axis. It is well established that hyperphosphatemia is associated with increased cardiovascular events and mortality in patients with chronic kidney disease (CKD). However, there are no randomized controlled trials that demonstrate a clear benefit on hard outcomes in lowering serum phosphate levels to recommended targets in the CKD or dialysis population. Read More

    Predictive Factors of One-Year Mortality in a Cohort of Patients Undergoing Urgent-Start Hemodialysis.
    PLoS One 2017 3;12(1):e0167895. Epub 2017 Jan 3.
    Nephrology Division, Medical School, University of São Paulo, São Paulo, Brazil.
    Background: Chronic kidney disease (CKD) affects 10-15% of adult population worldwide. Incident patients on hemodialysis, mainly those on urgent-start dialysis at the emergency room, have a high mortality risk, which may reflect the absence of nephrology care. A lack of data exists regarding the influence of baseline factors on the mortality of these patients. Read More

    Sleep quality and risk factors of atherosclerosis in predialysis chronic kidney disease.
    Int J Artif Organs 2017 Jan 19;39(11):563-569. Epub 2016 Dec 19.
    Konya Research and Training Hospital, Internal Medicine Department, Konya - Turkey.
    Introduction: Chronic kidney disease (CKD) patients have more frequent sleep disorders and cardiovascular disease than normals. Since arterial stiffness as a risk factor of atherosclerosis can be evaluated with pulse wave velocity (PWV), we aimed to investigate the prevalance of sleep quality (SQ) and the relationship between SQ and risk factors of atherosclerosis and whether there is a relationship between SQ and PWV (the indicator of arterial stiffness) in predialysis CKD patients.

    Methods: This cross-sectional study was carried out in CKD patients followed at the Nephrology Department in Konya, Turkey, between November 2014 and March 2015. Read More

    A Mutation in the Dmp1 Gene Alters Phosphate Responsiveness in Mice.
    Endocrinology 2017 Mar;158(3):470-476
    Departments of Medicine and.
    Mutations in the dentin matrix protein 1 (DMP1) gene cause autosomal recessive hypophosphatemic rickets (ARHR). Hypophosphatemia in ARHR results from increased circulating levels of the phosphaturic hormone, fibroblast growth factor 23 (FGF23). Similarly, elevated FGF23, caused by mutations in the PHEX gene, is responsible for the hypophosphatemia in X-linked hypophosphatemic rickets (XLH). Read More

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