11,098 results match your criteria Hyperparathyroidism Primary


Evaluation of endothelial function and diastolic function in patients with primary hyperparathyroidism before and after parathyroidectomy.

Cir Cir 2019 ;87(2):196-204

Unidad de Investigación en Endocrinología Experimental. Hospital de Especialidades Centro Médico Nacional Siglo XXI. Ciudad de México, México.

Introduction: Primary hyperparathyroidism (PHPT) is the leading cause of outpatient hypercalcemia associated with increased cardiovascular risk. The flow-mediated vasodilation (FMV) has been proposed as a non-invasive method for assessing endothelial function.

Objective: To compare the endothelial dysfunction measured by FMV and diastolic dysfunction in patients with PHPT before and after parathyroidectomy. Read More

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http://dx.doi.org/10.24875/CIRU.18000520DOI Listing
January 2019

Hypercalcaemic Crisis Due to Primary Hyperparathyroidism: Report of Two Cases.

J Crit Care Med (Targu Mures) 2019 Jan 4;5(1):34-39. Epub 2019 Feb 4.

University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Romania.

Introduction: A hypercalcaemic crisis, also called para thyrotoxicosis, hyper parathyroid crisis or parathyroid storm, is a complication of primary hyperparathyroidism (PHPT) and an endocrinology emergency that can have dramatic or even fatal consequences if it is not recognised and treated in time.

Case Presentation: Two cases presented in the emergency department with critical hypercalcaemic symptoms and severe elevation of serum calcium and parathyroid hormone levels, consistent with a hypercalcaemic crisis. The first case, a 16-year-old female patient, had imaging data that highlighted a single right inferior parathyroid adenoma and a targeted surgical approach was used. Read More

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http://dx.doi.org/10.2478/jccm-2019-0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369571PMC
January 2019

Factors associated with glomerular filtration rate variation in primary hyperparathyroidism after parathyroidectomy

Turk J Med Sci 2019 Feb 11;49(1):295-300. Epub 2019 Feb 11.

Background/aim: Prolonged hypercalcemia impairs renal function, and a reduced glomerular filtration rate (GFR) is typical in advanced primary hyperparathyroidism (PHPT). There are scarce data related to predictors of renal impairment in patients with PHPT. Hence, we aimed to evaluate changes in kidney function in PHPT patients after parathyroidectomy (PTX) and identify factors associated with GFR variation in these patients. Read More

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http://dx.doi.org/10.3906/sag-1806-181DOI Listing
February 2019

A novel interplay between irisin and PTH: from basic studies to clinical evidence in hyperparathyroidism.

J Clin Endocrinol Metab 2019 Feb 13. Epub 2019 Feb 13.

Department of Emergency and Organ Transplantation, University of Bari, Italy.

Context: Irisin is a hormone like-molecule that is cleaved and secreted by an unknown protease from fibronectin type III domain-containing protein 5 (FNDC5) and it ameliorates bone status, muscle atrophy and influences energy homeostasis. PTH exerts several metabolic effects that may interact with irisin's ones.

Objectives: To test the hypothesis that irisin and PTH mutually affect their biological action, we evaluated the FNDC5 mRNA and protein expression in myotubes treated with PTH (1-34) and PTH-r mRNA expression in osteoblasts treated with rec-irisin. Read More

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http://dx.doi.org/10.1210/jc.2018-02216DOI Listing
February 2019

[Intraoperative fluorescence angiography in primary hyperparathyroidism].

Authors:
H Dralle

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Sektion Endokrine Chirurgie, Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0907-3DOI Listing
February 2019

A Familial Case of a Whole Germline CDC73 Deletion Discordant for Primary Hyperparathyroidism.

Horm Res Paediatr 2019 Feb 8:1-8. Epub 2019 Feb 8.

Department of Pediatrics, National Hospital Organization Tokyo Medical Center, Tokyo,

Introduction: Primary hyperparathyroidism (PHPT) occurs as part of familial syndromes, including CDC73-related disorders caused by germline pathogenic variants of the CDC73 gene, particularly in early adulthood. Herein, we report a familial case of a whole germline CDC73 deletion discordant for PHPT.

Case Description: A 15-year-old boy was admitted to our hospital because of persistent nausea and vomiting. Read More

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http://dx.doi.org/10.1159/000495800DOI Listing
February 2019
1 Read

Update of the role of Nuclear Medicine techniques in the pre-surgical localization of primary hyperparathyroidism.

Rev Esp Med Nucl Imagen Mol 2019 Feb 6. Epub 2019 Feb 6.

Servicio de Medicina Nuclear, Hospital Clínico Universitario de Salamanca, Salamanca, España.

Primary hyperparathyroidism is one of the most frequent endocrine disorders. Its diagnosis is biochemical. Imaging techniques are not useful for the diagnosis of this pathology; they are just tools for pre-surgical localization. Read More

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http://dx.doi.org/10.1016/j.remn.2018.12.007DOI Listing
February 2019
1 Read

Autofluorescence in Parathyroidectomy: Signal Intensity Correlates with Serum Calcium and Parathyroid Hormone but Routine Clinical Use is Not Justified.

World J Surg 2019 Feb 8. Epub 2019 Feb 8.

Department of Endocrine Surgery, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK.

Background: The inability to identify the pathological gland at surgery results in failure to cure hyperparathyroidism in 2-5%. The poorly understood characteristic of parathyroid tissue to manifest autofluorescence (AF) under near-infrared (NIR) light has been promoted as an intraoperative adjunct in parathyroid surgery. This study sought to explore potential clinical correlates for AF and assess the clinical utility of AF in parathyroid surgery. Read More

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http://dx.doi.org/10.1007/s00268-019-04929-9DOI Listing
February 2019
2 Reads

Parathyroidectomy versus cinacalcet for tertiary hyperparathyroidism; a retrospective analysis.

Langenbecks Arch Surg 2019 Feb 7. Epub 2019 Feb 7.

Department of Surgery, Erasmus MC, University Medical Center Rotterdam, 's-Gravendijkwal 230, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.

Introduction: Tertiary hyperparathyroidism (tHPT), i.e., persistent HPT after kidney transplantation, affects 17-50% of transplant recipients. Read More

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http://dx.doi.org/10.1007/s00423-019-01755-4DOI Listing
February 2019
1 Read

[Erratum to: Diagnostics and treatment of primary hyperparathyroidism].

Authors:
C Nies

Chirurg 2019 Feb 6. Epub 2019 Feb 6.

Klinik für Allgemein- und Viszeralchirurgie, Niels-Stensen-Kliniken, Marienhospital Osnabrück, Bischofsstr. 1, 49074, Osnabrück, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0810-yDOI Listing
February 2019

PRE-OPERATIVE LOCALIZATION OF PARATHYROID ADENOMA: PERFORMANCE OF 4D MRI PARATHYROID PROTOCOL.

Endocr Pract 2019 Jan 18. Epub 2019 Jan 18.

From: 1Department of Surgery, University of Arizona Medical Center.

Introduction: Accurate pre-operative image localization is critical in selection of minimally invasive parathyroidectomy (MIP) as a surgical treatment approach in patients with primary hyperparathyroidism (PHPT). Sestamibi scan, ultrasound, computed tomography and conventional magnetic resonance imaging (MRI) has varying accuracy in localizing parathyroid adenoma. Our group had previously shown that 4D MRI is more accurate than conventional imaging in identifying single adenomas. Read More

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http://dx.doi.org/10.4158/EP-2018-0424DOI Listing
January 2019
5 Reads

BIOCHEMICAL DYNAMICS OF UNTREATED PRIMARY HYPERPARATHYROIDISM: AN OBSERVATIONAL STUDY.

Endocr Pract 2019 Jan 18. Epub 2019 Jan 18.

Department of Surgery, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA.

Objective: The natural biochemical history of untreated primary hyperparathyroidism (PHPT) is poorly understood. The purpose of this study was to determine the extent of biochemical fluctuations in patients with PHPT.

Design: Retrospective cohort study from January 1, 1995 to December 31, 2014. Read More

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http://dx.doi.org/10.4158/EP-2018-0489DOI Listing
January 2019
2 Reads

Comparison of hyperparathyroidism types and utility of dual radiopharmaceutical acquisition with Tc99m sestamibi and I for localization of rapid washout parathyroid adenomas.

Osteoporos Int 2019 Jan 31. Epub 2019 Jan 31.

Division of Nuclear Medicine, MedStar Washington Hospital Center, 110 Irving Street, NW, Suite GB1, Washington, DC, 20010, USA.

Tc99m-sestamibi dual-time imaging is a standard tool for localization of adenomas/hyperplasia in hyperparathyroidism. We investigated the degree and causes of localization failure among different types of hyperparathyroidism. Pre-operative parathyroid hormone levels and size of the gland were major determinants of Tc99m-sestamibi positivity; I scan may be helpful in localization failures. Read More

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http://dx.doi.org/10.1007/s00198-019-04846-6DOI Listing
January 2019

Diagnostic pitfalls in a cystic ectopic intrathyroidal parathyroid adenoma mimicking a nodular goiter: A care-compliant case report.

Medicine (Baltimore) 2019 Feb;98(5):e14351

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Rationale: Cystic parathyroid adenomas are rare and seldom arise in ectopically located glands which may be found within the carotid sheath, mediastinum, thymus, or thyroid grand. They cannot be detected consistently by any imaging methods. Unusual symptoms may bring about certain pitfalls and difficulties for the diagnosis of primary hyperparathyroidism (PHPT) caused by cystic parathyroid adenomas. Read More

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http://dx.doi.org/10.1097/MD.0000000000014351DOI Listing
February 2019
2 Reads

Computed tomography diagnosis of primary hyperparathyroidism.

Ter Arkh 2018 Apr;90(4):60-66

Russian Federal State Endocrinology Research Centre, Ministry of Health of Russia, Moscow, Russia.

The article presents data on modern approaches to the diagnosis of various manifestations of hyperparathyroidism according to multispiral computed tomography, which do not require morphological verification and ensure the correctness of the diagnostic process. The radiological picture and differential diagnostics of changes from parathyroid glands and bone structures at hyperparathyroidism are described in detail. Read More

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http://dx.doi.org/10.26442/terarkh201890460-66DOI Listing
April 2018
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Primary hyperparathyroidism clinical features on endocrinology in-patients clinic.

Authors:
I E Sapozhnikova

Ter Arkh 2018 Nov;90(10):51-54

Kirov State Medical University, the Ministry of Health of the Russia, Kirov, Russia.

Aim: The analysis clinical features of primary hyperparathyroidism on endocrinology in-patients clinic.

Materials And Methods: Open retrospective study, included data of patients who were hospitalized at Kirov Regional Hospital with primary hyperparathyroidism from January 01, 2013 to December 31, 2016.

Results: 23 patients were hospitalized. Read More

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http://dx.doi.org/10.26442/terarkh2018901051-54DOI Listing
November 2018
1 Read

Improved Control of Secondary Hyperparathyroidism in Hemodialysis Patients Switching from Oral Cinacalcet to Intravenous Etelcalcetide, Especially in Nonadherent Patients.

Blood Purif 2019 Jan 30:1-9. Epub 2019 Jan 30.

Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona,

Background: Etelcalcetide is a novel second-generation calcimimetic that, because of its intravenous administration, could improve treatment adherence in secondary hyperparathyroidism (SHPT). The aim of this study was to evaluate the effectiveness of etelcalcetide compared with that of cinacalcet in controlling SHPT in patients under hemodialysis.

Methods: A prospective observational study was performed in 29 patients with SHPT under hemodialysis who switched from cinacalcet to etelcalcetide with a follow-up of 6 months. Read More

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http://dx.doi.org/10.1159/000496562DOI Listing
January 2019
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Dwarfs and Giants of Parathyroid Adenomas-No Difference in Outcome After Parathyroidectomy.

J Surg Res 2019 Jan 25;237:56-60. Epub 2019 Jan 25.

Department of Endocrine Surgery, Churchill Cancer Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Backgroud: This study compares the outcome of parathyroidectomy for primary hyperparathyroidism (PHPT) in patients whose adenomas' weights were at the extremes of the distribution curve. As the size of parathyroid adenomas influences the success rate of localization studies for PHPT, it is possible that a difference in cure rate could be observed between subgroups of patients.

Materials And Methods: Data were retrieved from a prospective database maintained in a large university hospital. Read More

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http://dx.doi.org/10.1016/j.jss.2018.12.021DOI Listing
January 2019
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Potential Utility of Contrast-Enhanced Ultrasound in the Preoperative Evaluation of Primary Hyperparathyroidism.

J Ultrasound Med 2019 Jan 29. Epub 2019 Jan 29.

Departments of Endocrinology, La Paz University Hospital, Madrid, Spain.

Objectives: We aimed to compare the effectiveness of contrast-enhanced ultrasound (CEUS), technetium Tc 99m methoxyisobutylisonitrile ( Tc-MIBI) single-photon emission computed tomographic (SPECT) scintigraphy, and high-resolution ultrasound (US) in the detection of a pathologic parathyroid gland in patients with primary hyperparathyroidism (pHPT).

Methods: Twenty-nine consecutive patients with pHPT were prospectively enrolled and underwent preoperative imaging with Tc-MIBI SPECT scintigraphy, high-resolution US, and CEUS and subsequent parathyroidectomy. Contrast-enhanced US examinations were performed by an experienced examiner who was blinded to the results of scintigraphy and high-resolution US. Read More

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http://doi.wiley.com/10.1002/jum.14949
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http://dx.doi.org/10.1002/jum.14949DOI Listing
January 2019
2 Reads

Additional 20-Minute Intraoperative Parathormone Measurement Can Minimize Unnecessary Bilateral Neck Exploration.

J Surg Res 2019 Mar 1;235:264-269. Epub 2018 Nov 1.

Division of Endocrine Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida.

Background: Parathyroidectomy guided by intraoperative parathormone (ioPTH) monitoring for primary hyperparathyroidism (pHPT) confirms removal of all hyperfunctioning parathyroid glands. This study evaluates the utility of an additional 20-min ioPTH measurement in patients who fail to meet the >50% ioPTH drop criterion.

Methods: A retrospective review of prospectively collected data of 706 patients with pHPT who underwent parathyroidectomy guided by ioPTH monitoring was performed. Read More

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http://dx.doi.org/10.1016/j.jss.2018.08.043DOI Listing
March 2019
1 Read

Parathyroid-targeted overexpression of Regulator of G-Protein Signaling 5 (R GS5) causes hyperparathyroidism in transgenic mice.

J Bone Miner Res 2019 Jan 28. Epub 2019 Jan 28.

Division of General and Oncologic Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, 21201.

The relationship between impaired calcium sensing, dysregulated parathyroid hormone (PTH) secretion, and parathyroid cell proliferation in parathyroid neoplasia is not understood. We previously reported that a GTPase activating protein, regulator of G-protein signaling 5 (RGS5) is overexpressed in a subset of parathyroid tumors associated with primary hyperparathyroidism (PHPT), and that RGS5 can inhibit signaling from the calcium-sensing receptor (CASR). In vivo, we found that RGS5-null mice have abnormally low PTH levels. Read More

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http://dx.doi.org/10.1002/jbmr.3674DOI Listing
January 2019
2 Reads

The role of combined techniques of scintigraphy and SPECT/CT in the diagnosis of primary hyperparathyroidism: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14154

"Lucian Blaga" University of Sibiu, Romania.

Rationale: Primary hyperparathyroidism, usually as a result of a hyperfunctioning parathyroid gland, represents more than 90% cases of patients evaluated for hypercalcemia. Combined techniques of preoperative scintigraphy and SPECT/CT serve as a successful minimally-invasive parathyroidectomy. This recent imaging method provides four-dimensional functional images with advanced contrast resolution which greatly facilitates preoperative localization of parathyroid adenomas. Read More

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http://dx.doi.org/10.1097/MD.0000000000014154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358356PMC
January 2019
1 Read

Does Primary Hyperparathyroidism Have an Association with Thyroid Papillary Cancer? A Retrospective Cohort Study.

World J Surg 2019 Jan 24. Epub 2019 Jan 24.

Department of General Surgery, University of Health Sciences, Kartal Dr. Lutfi Kirdar Training and Research Hospital, 34890, Istanbul, Turkey.

Background: To investigate the relationship between primary hyperparathyroidism (pHPT) and papillary thyroid cancer (PTC).

Methods: The perioperative findings of 275 patients with pHPT who underwent surgery between January 2014 and December 2017 were retrospectively reviewed. Thirty-one patients were diagnosed with pHPT and PTC concurrently. Read More

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http://dx.doi.org/10.1007/s00268-019-04920-4DOI Listing
January 2019
1 Read
2.642 Impact Factor

Bilateral Neck Exploration for Sporadic Primary Hyperparathyroidism: Utilization Patterns in 5,597 Patients Undergoing Parathyroidectomy in the Collaborative Endocrine Surgery Quality Improvement Program.

J Am Coll Surg 2019 Jan 21. Epub 2019 Jan 21.

Department of Surgery Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University Medical Center, Nashville, TN. Electronic address:

Intro: For many surgeons, focused parathyroidectomy has become the preferred approach for the management of sporadic primary hyperparathyroidism (HPT). This study describes utilization patterns of bilateral neck exploration (BE) by endocrine surgeons participating in the Collaborate Endocrine Surgery Quality Improvement Program (CESQIP).

Methods: Using the CESQIP parathyroid dataset (2014-2017), utilization trends, demographic and clinical characteristics of patients undergoing BE vs. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2018.12.034DOI Listing
January 2019
2 Reads

Intraoperative Parathyroid Autofluorescence Detection in Patients with Primary Hyperparathyroidism.

Ann Surg Oncol 2019 Jan 23. Epub 2019 Jan 23.

Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Background: Intrinsic near-infrared (NIR) autofluorescence of the parathyroid gland may improve intraoperative gland identification without the need for contrast agent injection. Compared with patients undergoing surgery for thyroid disease, identification of pathologic parathyroid tissue in patients with hyperparathyroidism is essential. This study analyzed the utility of a novel real-time autofluorescence imaging system in patients with primary hyperparathyroidism enrolled in a prospective feasibility clinical trial. Read More

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http://dx.doi.org/10.1245/s10434-019-07161-wDOI Listing
January 2019

Perioperative characteristics, histological diagnosis, and outcome in cats undergoing surgical treatment of primary hyperparathyroidism.

Vet Surg 2019 Jan 21. Epub 2019 Jan 21.

VCA Canada-404 Veterinary Emergency and Referral, Newmarket, Ontario, Canada.

Objective: To report perioperative characteristics, complications, histopathologic diagnosis and outcome in cats undergoing surgical treatment for primary hyperparathyroidism (PHPT).

Study Design: Multi-institutional, retrospective case series.

Animals: Thirty-two client-owned cats. Read More

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http://dx.doi.org/10.1111/vsu.13165DOI Listing
January 2019
3 Reads
1.041 Impact Factor

Trimethylamine -Oxide and Cardiovascular Outcomes in Patients with End-stage Kidney Disease Receiving Maintenance Hemodialysis.

Clin J Am Soc Nephrol 2019 Jan 21. Epub 2019 Jan 21.

Department of Pharmacy and Therapeutics, Center for Clinical Pharmaceutical, Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.

Background And Objectives: Trimethylamine -oxide (TMAO), a compound derived from byproducts of intestinal bacteria, has been shown to accelerate atherosclerosis in rodents. To date, there are conflicting data regarding the association of serum TMAO with cardiovascular outcomes in patients with ESKD, a population exhibiting both high serum TMAO and excessive atherosclerosis.

Design, Setting, Participants, & Measurements: We measured baseline serum TMAO concentrations in a subset of participants (=1243) from the Evaluation of Cinacalcet Hydrochloride Therapy to Lower Cardiovascular Events (EVOLVE) trial and conducted analyses evaluating the association between baseline serum TMAO and cardiovascular outcomes. Read More

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http://dx.doi.org/10.2215/CJN.06190518DOI Listing
January 2019
1 Read

Management of familial hyperparathyroidism syndromes: MEN1, MEN2, MEN4, HPT-Jaw tumour, Familial isolated hyperparathyroidism, FHH, and neonatal severe hyperparathyroidism.

Best Pract Res Clin Endocrinol Metab 2018 Dec 28;32(6):861-875. Epub 2018 Sep 28.

EndOsMet, Endocrinology and Metabolic Bone Diseases Branch, Villa Donatello Private Hospital, Firenze, Italy; Endocrinology, Villa Alba Clinic, Villa Maria Group, Bologna, Italy. Electronic address:

While primary hyperparathyroidism (PHPT) generally represents a common endocrine disorder, being the more frequent cause of hypercalcemia in outpatients, familial forms of PHPT (FPHPT) account for no more than 2-5% of the overall PHPT. In the last decades, many technical progresses in both molecular and biochemical-radiological evaluation have been made, and substantial advancements in understanding these disorders have been reached. Differences both in the pathogenesis and clinical presentation exist among the various hyperparathyroid syndromic forms, and, since FPHPT is frequently associated to other endocrine, proliferative and/or functional disorders, as also non-endocrine tumours, with varying clinical spectrum of occurrence in each syndrome, its early clinically detection for appropriately preventing complications (i. Read More

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http://dx.doi.org/10.1016/j.beem.2018.09.010DOI Listing
December 2018
2 Reads

Management of normocalcemic primary hyperparathyroidism.

Best Pract Res Clin Endocrinol Metab 2018 Dec 28;32(6):837-845. Epub 2018 Sep 28.

Metabolic Bone Diseases Unit, Division of Endocrinology, Department of Medicine, College of Physician and Surgeons, Columbia University, 630 West 168th St, New York, NY, 10032, USA. Electronic address:

Traditional hypercalcemic primary hyperparathyroidism is a common endocrine disease. Patients with a history of nephrolithiasis or a suspected metabolic bone disease are increasingly being identified with elevated PTH concentrations in the setting of consistently normal serum and ionized calcium concentrations. In the absence of secondary causes of hyperparathyroidism, a diagnosis of normocalcemic primary hyperparathyroidism is reasonable. Read More

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http://dx.doi.org/10.1016/j.beem.2018.09.009DOI Listing
December 2018
1 Read

Non-surgical management of primary hyperparathyroidism.

Best Pract Res Clin Endocrinol Metab 2018 Dec 28;32(6):821-835. Epub 2018 Sep 28.

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. Electronic address:

The purpose of this chapter is to discuss the options available for patients with primary hyperparathyrodism (PHPT) not undergoing parathyroidectomy (PTx). Adequate hydration should be recommended in all patients. Calcium intake should not be restricted and vitamin D deficiency should be corrected aiming at a serum concentration of 25OHD of >20 ng/mL or even higher (>30 ng/mL according to some opinion leaders). Read More

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http://dx.doi.org/10.1016/j.beem.2018.09.006DOI Listing
December 2018
2 Reads

Non classical complications of primary hyperparathyroidism.

Best Pract Res Clin Endocrinol Metab 2018 Dec 18;32(6):805-820. Epub 2018 Jun 18.

Department of Medicine, Division of Endocrinology, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Several studies suggested that the condition of primary hyperparathyroidism (PHPT) may be associated not only with the classical bone, kidney and gastrointestinal consequences, but also with cardiovascular, neuromuscular and articular complications, impaired quality of life and increased cancer risk. However, the only cardiovascular complications associated with PHPT, which seems to improve after parathyroidectomy, is left ventricular hypertrophy, while, data regarding the reversibility of hypertension, valve calcifications and increased vascular stiffness are inconsistent. Parathyroidectomy seems to ameliorate neuropsychological, cognitive disturbances and quality of life in moderate-severe PHPT, while data in mild PHPT are less clear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1521690X183008
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http://dx.doi.org/10.1016/j.beem.2018.06.006DOI Listing
December 2018
4 Reads

Classical complications of primary hyperparathyroidism.

Best Pract Res Clin Endocrinol Metab 2018 Dec 12;32(6):791-803. Epub 2018 Sep 12.

Columbia University Medical College of Physicians & Surgeons, New York, USA. Electronic address:

Traditionally, classical complications of primary hyperparathyroidism are mainly represented by skeletal, kidney and gastrointestinal involvement. The old picture of osteitis fibrosa cystica is no longer commonly seen, at least in the western world. However, new imagining techniques have highlighted deterioration of skeletal tissue in patients with primary hyperparathyroidism not captured by traditional DXA measurement. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1521690X183010
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http://dx.doi.org/10.1016/j.beem.2018.09.001DOI Listing
December 2018
3 Reads

Genetics of parathyroids disorders: Overview.

Best Pract Res Clin Endocrinol Metab 2018 Dec 28;32(6):781-790. Epub 2018 Sep 28.

EndOsmet, Villa Donatello Private Hospital, Firenze, Italy; Villa Alba Clinic, Villa Maria Group, Bologna, Italy. Electronic address:

Several familial forms of primary hyperparathyroidism (PHTP) have been discovered over the past 25 years, and molecular test for their risk assessment has been widely increasing. These syndromic and non-syndromic forms have received benefits from the identification of the responsible genes whose mutations account for the genetic susceptibility to develop parathyroid tumours as also other endocrine and nonendocrine tumours. In recent years, care options have been made available to patients and families with hereditary PHPT, and the process of systematically assessing the genetic risk has been becoming increasingly important. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1521690X183011
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http://dx.doi.org/10.1016/j.beem.2018.09.011DOI Listing
December 2018
4 Reads

18F-Fluorocholine PET/CT and Parathyroid 4D Computed Tomography for Primary Hyperparathyroidism: The Challenge of Reoperative Patients.

World J Surg 2019 Jan 18. Epub 2019 Jan 18.

Department of Nuclear Medicine, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.

Background: To evaluate FCH-PET/CT and parathyroid 4D-CT so as to guide surgery in patients with primary hyperparathyroidism (pHPT) and prior neck surgery.

Methods: Medical records of all patients referred for a FCH-PET/CT in our institution were systematically reviewed. Only patients with pHPT, a history of neck surgery (for pHPT or another reason) and an indication of reoperation were included. Read More

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http://dx.doi.org/10.1007/s00268-019-04910-6DOI Listing
January 2019
4 Reads

Effect of Endogenous Parathyroid Hormone on Bone Geometry and Skeletal Microarchitecture.

Calcif Tissue Int 2019 Jan 18. Epub 2019 Jan 18.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.

Parathyroid hormone (PTH) has anabolic or catabolic effects on bones; however, the skeletal effect of endogenous PTH on cortical and trabecular bones is not yet clear. Therefore, we aimed to examine the effects of an excess and a deficiency of endogenous PTH on the lumbar spine trabecular bone score (TBS) and bone geometry using dual-energy X-ray absorptiometry. We retrospectively included 70 patients with primary hyperparathyroidism (PHPT), 26 patients with idiopathic or postoperative hypoparathyroidism (HypoPT), and 96 normal controls matched by age, sex, and body mass index. Read More

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http://link.springer.com/10.1007/s00223-019-00517-0
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http://dx.doi.org/10.1007/s00223-019-00517-0DOI Listing
January 2019
6 Reads

The role of ultrasound in the diagnosis of the coexistence of primary hyperparathyroidism and non-medullary thyroid carcinoma.

BMC Med Imaging 2019 Jan 18;19(1). Epub 2019 Jan 18.

Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, 600 Yishan Road, Shanghai, 200233, China.

Background: The coexistence of primary hyperparathyroidism(PHPT) and papillary thyroid cancer(PTC) is a known entity; it is a rare and complicated setting for diagnostic imaging.

Methods: After reviewing clinical data of 112 patients who had been treated for PHPT in our facility between January 2015 and December 2017, we identified 7 non-medullary thyroid carcinoma (NMTC) (6.25%). Read More

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http://dx.doi.org/10.1186/s12880-019-0306-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339388PMC
January 2019
3 Reads

A Bayesian network analysis on comparative efficacy of treatment strategies for dialysis patients with secondary hyperparathyroidism.

Exp Ther Med 2019 Jan 31;17(1):531-540. Epub 2018 Oct 31.

Nephrology Department, The First People's Hospital of Foshan, Foshan, Guangdong 528000, P.R. China.

For dialysis patients with end-stage kidney disease and secondary hyperparathyroidism (SHPT), there are three therapeutic treatment options: Cinacalcet, paricalcitol and cinacalcet plus low-dose vitamin D analogues. However, their comparative efficacy remains unclear at present. Thus, in the current study, a Bayesian network analysis was conducted to evaluate the relative efficacy and safety of these three therapeutic regimens. Read More

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http://dx.doi.org/10.3892/etm.2018.6906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307356PMC
January 2019
3 Reads

Long-term follow-up of RET Y791F carriers in Denmark 1994-2017: A National Cohort Study.

J Surg Oncol 2019 Jan 15. Epub 2019 Jan 15.

Department of ORL, Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.

Background And Objectives: Recently, a comprehensive study presented evidence that a long-disputed REarranged during Transfection (RET) variant, RET Y791F, should be classified as nonpathogenic. In spite of this, several subsequently published papers, including the revised American Thyroid Association guidelines for medullary thyroid carcinoma, refer to the variant as pathogenic. This study presents data from a unique national Danish cohort of RET Y791F carriers who have been followed by watchful waiting instead of being subjected to early thyroidectomy, to determine if any carrier shows evidence of multiple endocrine neoplasia 2A (MEN2A) at long-term follow-up. Read More

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http://doi.wiley.com/10.1002/jso.25371
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http://dx.doi.org/10.1002/jso.25371DOI Listing
January 2019
6 Reads

Normocalcemic Hyperparathyroidism.

Authors:
Sabrina Corbetta

Front Horm Res 2019 19;51:23-39. Epub 2018 Nov 19.

Parathyroid hormone (PTH) disorders are characterized by a wide spectrum of clinical and biochemical presentations. The increasing use of serum PTH assay in the set of the diagnostic workout in patients with osteoporosis has identified patients with features of surgically confirmed primary hyperparathyroidism (PHPT) associated with persistent normal serum calcium levels, which has been recognized as a distinct entity from hypercalcemic PHPT (HPHPT) by the last international consensus. Normocalcemic PHPT (NPHPT) affects about 6-8% of PHPT patients. Read More

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http://dx.doi.org/10.1159/000491036DOI Listing
November 2018
5 Reads

Nonparathyroid Hypercalcemia.

Authors:
David Goltzman

Front Horm Res 2019 19;51:77-90. Epub 2018 Nov 19.

Primary hyperparathyroidism is among the most common causes of hypercalcemia. However, ingestion of medication, including hydrochlorathiazide, lithium, and foscarnet, excessive vitamin A ingestion, endocrinopathies such as hyperthyroidism, adrenal insufficiency, and acromegaly, abnormal nutrient intake such as parenteral nutrition in preterm infants and milk-alkali syndrome, and prolonged immobilization have all been associated with hypercalcemia. The most common cause of nonparathyroid hypercalcemia is neoplasia. Read More

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http://dx.doi.org/10.1159/000491040DOI Listing
November 2018
2 Reads

Parathyroid Carcinoma.

Front Horm Res 2019 19;51:63-76. Epub 2018 Nov 19.

Parathyroid carcinoma (PC) is a rare endocrine malignancy, accounting for <1% of all cases of sporadic primary hyperparathyroidism (PHPT) and up to 15% in the hereditary hyperparathyroidism-jaw tumor syndrome. Genomic alterations identified in PC are mostly represented by CDC73 gene mutations, codifying for a loss-of-function protein termed parafibromin. Whole exome sequencing identified mutations in other genes, such as mTOR, KMT2D, CDKN2C, THRAP3, PIK3CA, and EZH2 genes, CCND1 gene amplification. Read More

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http://dx.doi.org/10.1159/000491039DOI Listing
November 2018
2 Reads

Asymptomatic Primary Hyperparathyroidism.

Authors:
Bart L Clarke

Front Horm Res 2019 19;51:13-22. Epub 2018 Nov 19.

Asymptomatic primary hyperparathyroidism has become the most common presentation of primary hyperparathyroidism in Europe and North America, and an increasingly common presentation in other parts of the world. As many as 25% of asymptomatic patients may develop indications for parathyroidectomy when followed long-term for up to 15 years. Patients who remain asymptomatic should be monitored for the development of complications that justify surgery. Read More

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http://dx.doi.org/10.1159/000491035DOI Listing
November 2018

Familial Hypocalciuric Hypercalcemia and Neonatal Severe Hyperparathyroidism.

Front Horm Res 2019 19;51:52-62. Epub 2018 Nov 19.

Familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT) are genetically determined variants of primary hyperparathyroidism. FHH usually has a benign course, and patients do not require treatment, whereas NSHPT is a severe disorder often requiring early parathyroidectomy for young patients to survive. Recent discoveries in the genetic basis and new findings in therapeutic approaches have led to a great interest in these rare diseases. Read More

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http://dx.doi.org/10.1159/000491038DOI Listing
November 2018
1 Read

Familial and Hereditary Forms of Primary Hyperparathyroidism.

Front Horm Res 2019 19;51:40-51. Epub 2018 Nov 19.

Individuals with a familial predisposition to the development of parathyroid tumors constitute a small minority of all patients with primary hyperparathyroidism (PHPT). These familial syndromes exhibit Mendelian inheritance patterns and the main causative genes in most families have been identified. They include multiple endocrine neoplasia (MEN; types 1, 2A, and 4), hyperparathyroidism-jaw tumor (HPT-JT) syndrome, familial isolated hyperparathyroidism, familial hypocalciuric hypercalcemia (FHH), and neonatal severe PHPT. Read More

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https://www.karger.com/Article/FullText/491037
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http://dx.doi.org/10.1159/000491037DOI Listing
November 2018
3 Reads

Primary Hyperparathyroidism.

Authors:
Laura Masi

Front Horm Res 2019 19;51:1-12. Epub 2018 Nov 19.

The 4 parathyroid glands derive from the third and fourth pharyngeal pouches and descend caudally to the anterior neck. Through the secretion of parathyroid hormone (PTH), the parathyroid glands are primarily responsible for maintaining extracellular calcium and phosphorus concentrations. Hypercalcemia may be distinguished in parathyroid-hypercalcemia and nonparathyroid hypercalcemia. Read More

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https://www.karger.com/Article/FullText/491034
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http://dx.doi.org/10.1159/000491034DOI Listing
November 2018
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A Case of Pregnancy Complicated by Primary Hyperparathyroidism Due to a Parathyroid Adenoma.

Am J Case Rep 2019 Jan 14;20:53-59. Epub 2019 Jan 14.

Laboratory of Age-Related Metabolic and Endocrine Disorders, The Russian Gerontology Clinical Research Center, Moscow, Russian Federation.

BACKGROUND Primary hyperparathyroidism is most common in women during the menopause and its occurrence in pregnant women is rare. However, because neonatal mortality is associated with maternal hyperparathyroidism, early diagnosis is essential. This report describes the case of a late diagnosis of primary hyperparathyroidism in a 28-year-old pregnant woman and describes the effects on the mother and neonate. Read More

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http://dx.doi.org/10.12659/AJCR.912436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340266PMC
January 2019
2 Reads

Analysis of Activating GCM2 Sequence Variants in Sporadic Parathyroid Adenomas.

J Clin Endocrinol Metab 2019 Jan 8. Epub 2019 Jan 8.

Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, CT, USA.

Context: Sporadic, solitary parathyroid adenoma is the commonest cause of primary hyperparathyroidism (PHPT). Apart from germline variants in certain cyclin dependent kinase inhibitor genes, and occasionally in MEN1, CASR, or CDC73, little is known about possible genetic variants in the population that may confer increased risk for development of typical sporadic adenoma. Transcriptionally-activating germline variants, especially within in the C-terminal conserved inhibitory domain (CCID), of GCM2, encoding a transcription factor required for parathyroid gland development, have recently been reported in association with familial and sporadic PHPT. Read More

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http://dx.doi.org/10.1210/jc.2018-02517DOI Listing
January 2019
1 Read
6.209 Impact Factor

Parathyroid Apoplexy Following Cinacalcet Treatment in Primary Hyperparathyroidism.

Front Endocrinol (Lausanne) 2018 21;9:777. Epub 2018 Dec 21.

Unit of Endocrinology, Department of Medicine and Sciences of Aging and Ce.S.I.-Me.T., University of Chieti-Pescara, Chieti, Italy.

Cinacalcet, a calcimimetic drug, is considered a safe and valid option for the treatment of hypercalcemia in patients with primary hyperparathyroidism who are unable to undergo parathyroidectomy. Hypocalcemia and gastrointestinal adverse reactions are the main side effects reported in patients treated with cinacalcet. We present here the case of an 80-years-old patient with primary hyperparathyroidism treated with cinacalcet for 17 months who developed a severe and symptomatic episode of hypocalcemia requiring hospitalization 1 month after reaching a daily dose of 180 mg. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00777
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http://dx.doi.org/10.3389/fendo.2018.00777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308315PMC
December 2018
15 Reads

Bone mineral density evolution and incidence of fractures in a cohort of patients with primary hyperparathyroidism treated with parathyroid surgery vs active surveillance during 6 years of follow-up.

Endocrinol Diabetes Nutr 2019 Jan 6;66(1):41-48. Epub 2018 Jul 6.

Servicio de Endocrinología, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Universidad de Cantabria, , Santander (Cantabria), España.

Introduction: The need for parathyroidectomy to treat asymptomatic patients with primary hyperparathyroidism is controversial. The aim of this study was to assess the impact of parathyroidectomy vs. surveillance on skeletal outcomes such as bone mineral density (BMD) and incident fractures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S25300164183013
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http://dx.doi.org/10.1016/j.endinu.2018.05.010DOI Listing
January 2019
8 Reads

Synchronous primary hyperparathyroidism, follicular thyroid carcinoma, and papillary thyroid carcinoma.

Chin Med J (Engl) 2019 Jan;132(2):240-241

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.

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http://dx.doi.org/10.1097/CM9.0000000000000018DOI Listing
January 2019
2 Reads