11,178 results match your criteria Hyperparathyroidism Primary


Focused Parathyroidectomy Under Local Anesthesia - A Feasibility Study.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):67-71

Department of Endocrine Surgery, CMC Hospital, Vellore, Tamil Nadu, India.

Purpose: We conducted this study to evaluate the feasibility, patient satisfaction, and cost of performing focused parathyroidectomy under local anesthesia (LA) and mild sedation, administered and monitored by a surgeon.

Materials And Methods: This was a prospective observational study of 30 patients with primary hyperparathyroidism (PHPT) undergoing a focused parathyroidectomy under LA and mild sedation at a single institution. The clinical features, gland weight, operating time, procedure time, postoperative pain scores, overall patient satisfaction, postoperative nausea and vomiting, analgesic requirements, complications, cost, and cure rates were documented. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijem.IJEM_590_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446694PMC

A Comparison between Silent and Symptomatic Renal Stones in Primary Hyperparathyroidism.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):46-49

Department of Nephrology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India.

Background: Nephrolithiasis is a common complication of primary hyperparathyroidism (PHPT), and in a subgroup of patients stones are clinically silent. Patients with silent and symptomatic stones may differ biochemically. There is a scarcity of data available comparing patients with silent and symptomatic renal stones in PHPT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijem.IJEM_558_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446667PMC

American Head and Neck Society Endocrine Surgery Section update on parathyroid imaging for surgical candidates with primary hyperparathyroidism.

Head Neck 2019 Apr 19. Epub 2019 Apr 19.

Division of Head and Neck Endocrine Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland.

Health care consumer organizations and insurance companies increasingly are scrutinizing value when considering reimbursement policies for medical interventions. Recently, members of several American Academy of Otolaryngology-Head & Neck Surgery (AAO-HNS) committees worked closely with one insurance company to refine reimbursement policies for preoperative localization imaging in patients undergoing surgery for primary hyperparathyroidism. This endeavor led to an AAO-HNS parathyroid imaging consensus statement (https://www. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hed.25781DOI Listing
April 2019
1 Read

Primary hyperparathyroidism.

Authors:
Ao Wang Lei Yuan

Clin Case Rep 2019 Apr 5;7(4):849-850. Epub 2019 Mar 5.

Department of Endocrinology, the Second Affiliated Hospital Chongqing Medical University Chongqing China.

We report a case of hyperparathyroidism with hypercalcemia caused by a giant parathyroid adenoma. We use a technetium sestamibi scan to locate parathyroid mass. Bone emission computed tomography revealed the classic signs of metabolic osteopathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccr3.2035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452475PMC

Parathyroid carcinoma, an unusual cause of primary hyperparathyroidism.

Acta Otorrinolaringol Esp 2019 Apr 14. Epub 2019 Apr 14.

Servicio de Otorrinolaringología, Complexo Hospitalario Universitario A Coruña, A Coruña, España.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00016519193003
Publisher Site
http://dx.doi.org/10.1016/j.otorri.2018.11.001DOI Listing
April 2019
1 Read

INCREASED MORTALITY IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM: DOES SURGERY MAKE A DIFFERENCE?

Endocr Pract 2019 Apr;25(4):335-339

Primary hyperparathyroidism (PHPT) is functionally characterized by an inappropriately raised secretion of parathyroid hormone, leading to raised serum calcium levels. Some patients are referred for parathyroidectomy, and some are managed conservatively. The aim of the audit was to compare the mortality outcomes between the two groups. Read More

View Article

Download full-text PDF

Source
http://journals.aace.com/doi/10.4158/EP-2018-0407
Publisher Site
http://dx.doi.org/10.4158/EP-2018-0407DOI Listing
April 2019
1 Read

Clinical Features of Multiple Endocrine Neoplasia Type 4 - Novel pathogenic variant and review of published cases.

J Clin Endocrinol Metab 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical Research, Faculty of Health, University of Southern Denmark (SDU).

Context: The clinical phenotype of multiple endocrine neoplasia type 4 (MEN4) is undefined due to a limited number of published cases. Knowledge on disease manifestation in MEN4 is essential for developing prevention programs and treatment.

Objective: To expand current knowledge of the MEN4 phenotype including assessment of penetrance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2019-00082DOI Listing
April 2019
1 Read

Diagnosis and treatment of confirmed and suspected primary hyperparathyroidism in equids: 17 cases (1999-2016).

Equine Vet J 2019 Apr 13. Epub 2019 Apr 13.

Baker Institute for Animal Health, Cornell University College of Veterinary Medicine, Ithaca, New York, 14853, USA.

Background: Primary hyperparathyroidism is uncommon in equids.

Objectives: To describe the diagnostic findings and efficacy of treatment in equids with primary hyperparathyroidism.

Study Design: Retrospective case series describing sixteen horses and one mule. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/evj.13120
Publisher Site
http://dx.doi.org/10.1111/evj.13120DOI Listing
April 2019
7 Reads

Deficiency in the secreted protein Semaphorin3d causes abnormal parathyroid development in mice.

J Biol Chem 2019 Apr 12. Epub 2019 Apr 12.

Cardiovascular and Metabolic Disorders Program, Duke NUS Medical School, Singapore.

Primary hyperparathyroidism (PHPT) is a common endocrinopathy characterized by hypercalcemia and elevated levels of parathyroid hormone. The primary cause for PHPT is a benign overgrowth of parathyroid tissue causing excessive secretion of parathyroid hormone. However, the molecular etiology of PHPT is incompletely defined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA118.007063DOI Listing
April 2019
1 Read

Biological secondary contributors to osteoporosis in fractured patients, is an early systematic assay relevant?

Joint Bone Spine 2019 Apr 9. Epub 2019 Apr 9.

Rheumatology Department, Cochin Hospital, 75014 Paris, France; INSERM U1153, 75014 Paris France. Electronic address:

Objective: To evaluate the prevalence of biological abnormalities leading to secondary osteoporosis in recently fractured patients.

Methods: Adults older than 50, hospitalized for a nonvertebral fracture from July 2015 to October 2016, were assessed for bone fragility contributors in the Orthopedics Department. Bone mineral density (BMD) measurements and Vertebral Fracture assessment (VFA) were performed within 3 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbspin.2019.03.009DOI Listing
April 2019
1 Read

Intraoperative parathyroid hormone levels ≤40 pg/mL are associated with the lowest persistence rates after parathyroidectomy for primary hyperparathyroidism.

Surgery 2019 Apr 8. Epub 2019 Apr 8.

University of Michigan Medical School, Ann Arbor; Department of Surgery, University of Michigan, Ann Arbor. Electronic address:

Background: Intraoperative parathyroid hormone (IOPTH) monitoring is used to predict biochemical cure during parathyroidectomy for primary hyperparathyroidism; however, there is variability in the intraoperative parathyroid hormone criteria used by surgeons to predict normocalcemia after parathyroidectomy. This study sought to determine the intraoperative parathyroid hormone criteria correlated with the lowest rates of persistent hyperparathyroidism after parathyroidectomy for primary hyperparathyroidism.

Materials And Methods: This is a retrospective cohort study of 2,654 patients with primary hyperparathyroidism who underwent parathyroidectomy with intraoperative parathyroid hormone monitoring at a single institution from 1999 to 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.surg.2019.01.024DOI Listing
April 2019
1 Read

25-Hydroxyvitamin D and Vitamin D Binding Protein Levels in Patients With Primary Hyperparathyroidism Before and After Parathyroidectomy.

Front Endocrinol (Lausanne) 2019 27;10:171. Epub 2019 Mar 27.

Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, United States.

To evaluate vitamin D binding protein and free 25-hydroxyvitamin D [25(OH)D] levels in healthy controls compared to primary hyperparathyroidism (PHPT) patients, and to examine PHPT before and after surgery. Seventy-five PHPT patients and 75 healthy age, gender, and body mass index (BMI) -matched control subjects were examined. In addition, 25 PHPT patients underwent parathyroidectomy and had a 3-month follow up visit. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fendo.2019.00171
Publisher Site
http://dx.doi.org/10.3389/fendo.2019.00171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446311PMC
March 2019
13 Reads

Bradycardia secondary to primary hyperparathyroidism.

J Int Med Res 2019 Apr 10:300060519841156. Epub 2019 Apr 10.

1 Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.

Clinical doctors rarely associate hyperparathyroidism with significant bradyarrhythmia. We report a rare case of a patient initially misdiagnosed with primary sick sinus syndrome, which was eventually shown to be secondary to primary hyperparathyroidism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300060519841156DOI Listing
April 2019
1 Read

Parathyroid Computed Tomography Angiography: Early Experience with a Novel Imaging Technique in Primary Hyperparathyroidism.

Otolaryngol Head Neck Surg 2019 Apr 9:194599819842106. Epub 2019 Apr 9.

4 Department of Radiology, Naval Medical Center San Diego, San Diego, CA.

Objectives: To describe parathyroid computed tomography angiography (PCTA), determine its accuracy, and, as a secondary objective, calculate its mean radiation dosimetry.

Study Design: Retrospective chart review of patients who underwent parathyroidectomy for primary hyperparathyroidism from 2007 to 2015.

Setting: Single-center tertiary care academic military hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0194599819842106DOI Listing
April 2019
1 Read

The effect of parathyroidectomy on patients' symptoms in tertiary hyperparathyroidism.

Head Neck 2019 Apr 7. Epub 2019 Apr 7.

Singhealth Duke-NUS Head & Neck Centre, Singapore, Singapore.

Background: The efficacy of parathyroidectomy for primary and secondary hyperparathyroidism is well-established but evidence in tertiary hyperparathyroidism is lacking. We examined parathyroidectomy's effect in tertiary hyperparathyroidism.

Methods: Patients with tertiary hyperparathyroidism who underwent parathyroidectomy were followed up for 12 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hed.25750DOI Listing
April 2019
7 Reads

Complications Encountered with Non-adherence to Regular Follow-up in the Long-term Medical Management of Hyperparathyroidism.

Cureus 2019 Jan 26;11(1):e3966. Epub 2019 Jan 26.

Internal Medicine, Louis Stokes Cleveland VA Medical Center, Cleveland, USA.

Primary hyperparathyroidism is the third most commonly encountered endocrine disorder after diabetes and thyroid diseases. There has been a constant debate between medical and surgical management of the disorder. Guidelines clearly indicate surgical management over medical management in symptomatic patients and asymptomatic patients below 50 years of age. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.3966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436886PMC
January 2019
1 Read

Primary Hyperparathyroidism in Pregnancy: A Multicenter Case Series of 4 Patients from Northern India.

J Obstet Gynaecol India 2019 Apr 5;69(Suppl 1):31-35. Epub 2018 Jul 5.

7Department of Gastroenterology, Fortis Escorts Hospital, Jaipur, Rajasthan India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13224-018-1148-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431693PMC
April 2019
1 Read

Efficacy and safety of evocalcet in Japanese peritoneal dialysis patients.

Clin Exp Nephrol 2019 Apr 6. Epub 2019 Apr 6.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Namics 301, 4-24-51 Takanawa, Minato-ku, Tokyo, 108-0074, Japan.

Background: Secondary hyperparathyroidism (SHPT) is a serious and common complication in patients receiving peritoneal dialysis (PD). Cinacalcet is currently the recommended therapy for SHPT; however, gastrointestinal (GI)-related symptoms can result in low adherence and high discontinuation rates. Evocalcet is a novel calcimimetic agent that has non-inferior efficacy while providing a more tolerable safety profile. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10157-019-01692-y
Publisher Site
http://dx.doi.org/10.1007/s10157-019-01692-yDOI Listing
April 2019
3 Reads

Mild sporadic primary hyperparathyroidism: high rate of multiglandular disease is associated with lower surgical cure rate.

Langenbecks Arch Surg 2019 Apr 6. Epub 2019 Apr 6.

Service de Médecine Nucléaire, CHU de Nantes, Hôtel Dieu, Paris, France.

Background: Mild primary hyperparathyroidism (serum calcium ≤ 2.85 mmol/L) is the most representative form of pHPT nowadays. The aim of this study was to evaluate its subtypes and the multiglandular disease (MGD) rate as it may lower the sensitivity of preoperative parathyroid scintigraphy and the surgical cure rate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00423-019-01782-1DOI Listing
April 2019
2 Reads

Parkinsonism as presenting symptom of primary hyperparathyroidism: Improvement after surgery.

Cir Cir 2019 ;86(1):96-98

Department of General and Digestive System Surgery, Hospital General Universitario Reina Sofía, Murcia, Spain.

Introduction: Hypercalcemia can cause different neurological disorders, depending on the calcium level. We report an exceptional case of primary hyperparathyroidism presenting as neurological alteration and it has favourable outcome after parathyroidectomy.

Case Report: A 74-year-old woman presented with progressive cognitive deterioration and impaired motor function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.24875/CIRUE.M18000015DOI Listing
January 2019
1 Read

Management of brown tumor of spine with primary hyperparathyroidism: A case report and literature review.

Medicine (Baltimore) 2019 Apr;98(14):e15007

Spinal tumor center, Department of Orthopaedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Rationale: Brown tumor (BT) is a rare benign lesion in skeletal system. It is especially rare secondary to primary hyperparathyroidism (HPT). The differential diagnosis can be misleading due to its diversified clinical characteristics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015007DOI Listing
April 2019
3 Reads

Intraoperative verification of parathyroid glands in primary and secondary hyperparathyroidism using near-infrared autofluorescence (IOPA).

Updates Surg 2019 Apr 3. Epub 2019 Apr 3.

Schwarzwald-Baar Klinikum Villingen-Schwenningen, Klinikstrasse 11, Villingen-Schwenningen, 78052, Germany.

Intraoperative verification of parathyroid glands relies on visual identification by the surgeon and, with some time delay, on serum parathormon measurements and frozen section. Fluorescence imaging, however, is an instant on-table method for direct visualization of parathyroid tissue which is known to exhibit increased autofluorescence intensity when exposed to near-infrared light. In this retrospective observational study, we evaluate the clinical use of this method in a series of patients with primary and secondary hyperparathyroidism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13304-019-00652-1DOI Listing
April 2019
1 Read

Clinical Value of Tc99m-MIBI SPECT/CT Versus 4D-CT or US in Management of Patients With Hyperparathyroidism.

Ear Nose Throat J 2019 Mar 19;98(3):149-157. Epub 2019 Feb 19.

2 Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Lewis Katz School of Medicine, Temple University School of Medicine, Philadelphia, PA, USA.

Localization of parathyroid adenomas for treatment of primary hyperparathyroidism can be challenging. This retrospective study compared single-photon emission computed tomography/computed tomography (SPECT/CT), 4D-CT, and US studies in detection of adenomas prior to surgery. A retrospective chart review was performed on all consecutive patients with parathyroid adenoma presenting to an urban tertiary care medical center. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/0145561319828668
Publisher Site
http://dx.doi.org/10.1177/0145561319828668DOI Listing
March 2019
5 Reads

Parathyroid carcinoma: a case report.

Exp Oncol 2019 03;41(1):72-75

State Scientific Institution "Scientific-Practical Centre of Preventive and Clinical Medicine", State Administration of Affairs, Kyiv, Ukraine.

Parathyroid carcinoma (PC) is an uncommon cause of primary hyperparathyroidism (pHPT). The tumor is mostly functioning with following high serum calcium and parathyroid hormone (PTH) levels. Consideration of PC in differential diagnosis of pHPT is important because the mortality and the prognosis depend on early recognition and surgical approach. Read More

View Article

Download full-text PDF

Source
March 2019
2 Reads

Dual Tracer 99mTc-Pertechnetate/99mTc-MIBI Dual-Time-Point SPECT/CT Parathyroid Gland Assessment Regarding to Parathyroid Gland Size and Biochemical Parameters - Two Years Single Imaging Centre Experience.

Acta Medica (Hradec Kralove) 2019 ;62(1):1-5

Nuclear Medicine Department, University Hospital Hradec Králové, Czech Republic.

Introduction: Preoperative parathyroid imaging is inevitable part of focused parathyroid surgery. The aim of our study was assessment of parathyroid scintigraphy diagnostic accuracy regarding to size and metabolic parameters of hyperfunctioning parathyroid tissue.

Material And Methods: Parathyroid scintigraphy for suspected primary hyperparathyroidism was performed in 95 patients during years 2015 and 2016. Read More

View Article

Download full-text PDF

Source
https://actamedica.lfhk.cuni.cz/62/1/0001/
Publisher Site
http://dx.doi.org/10.14712/18059694.2019.38DOI Listing
January 2019
6 Reads

Detectability and surgical outcomes in parathyroid surgery - a single-centre experience.

Br J Oral Maxillofac Surg 2019 Mar 28. Epub 2019 Mar 28.

Department of Oral and Maxillofacial Surgery, Western Sussex Hospital, St Richards Hospital, Spitalfield Ln, Chichester PO19 6SE, United Kingdom.

The incidence of primary hyperparathyroidismand referrals for the removal of parathyroid adenomas are increasing. Factors that improve the detectability, and ultimately the surgical outcome, are the focus of this retrospective study. We included 117 patients who had parathyroid operations with intraoperative monitoring of parathyroid hormone (PTH). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S02664356193007
Publisher Site
http://dx.doi.org/10.1016/j.bjoms.2019.03.007DOI Listing
March 2019
7 Reads

A mathematical model of parathyroid gland biology.

Physiol Rep 2019 Apr;7(7):e14045

Renal Research Institute, New York City, New York.

Altered parathyroid gland biology in patients with chronic kidney disease (CKD) is a major contributor to chronic kidney disease-mineral bone disorder (CKD-MBD). This disorder is associated with an increased risk of bone disorders, vascular calcification, and cardiovascular events. Parathyroid hormone (PTH) secretion is primarily regulated by the ionized calcium concentration as well as the phosphate concentration in the extracellular fluid and vitamin D. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14814/phy2.14045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440916PMC
April 2019
4 Reads

Innervation is higher above Bone Remodeling Surfaces and in Cortical Pores in Human Bone: Lessons from patients with primary hyperparathyroidism.

Sci Rep 2019 Mar 29;9(1):5361. Epub 2019 Mar 29.

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.

Mounting evidence from animal studies suggests a role of the nervous system in bone physiology. However, little is known about the nerve fiber localization to human bone compartments and bone surface events. This study reveals the density and distribution of nerves in human bone and the association of nerve profiles to bone remodeling events and vascular structures in iliac crest biopsies isolated from patients diagnosed with primary hyperparathyroidism (PHPT). Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41598-019-41779-w
Publisher Site
http://dx.doi.org/10.1038/s41598-019-41779-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441095PMC
March 2019
10 Reads

Parafibromin immunostainings of parathyroid tumors in clinical routine: a near-decade experience from a tertiary center.

Mod Pathol 2019 Mar 28. Epub 2019 Mar 28.

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

The cell division cycle 73 gene is mutated in familial and sporadic forms of primary hyperparathyroidism, and the corresponding protein product parafibromin has been proposed as an adjunct immunohistochemical marker for the identification of cell division cycle 73 mutations and parathyroid carcinoma. Here, we present data from our experiences using parafibromin immunohistochemistry in parathyroid tumors since the marker was implemented in clinical routine in 2010. A total of 2019 parathyroid adenomas, atypical adenomas, and carcinomas were diagnosed in our department, and parafibromin staining was ordered for 297 cases with an initial suspicion of malignant potential to avoid excessive numbers of false positives. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41379-019-0252-6DOI Listing
March 2019
1 Read

Bone mineral density, bone turnover markers, and incident fractures in de novo kidney transplant recipients.

Kidney Int 2019 Mar 4. Epub 2019 Mar 4.

Department of Nephrology and Renal Transplantation, University Hospitals Leuven and Laboratory of Nephrology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.

Kidney transplant recipients are at increased risk of fractures. This prospective observational study investigated whether areal bone mineral density (aBMD) as assessed by dual-energy x-ray absorptiometry can predict incident fragility fractures in de novo kidney transplant recipients and whether bone turnover markers increase diagnostic accuracy. Parameters of bone mineral metabolism including parathyroid hormone (PTH), fibroblast growth factor 23, sclerostin, calcidiol and calcitriol, and bone turnover markers were assessed in blood samples collected immediately prior to kidney transplantation in 518 adult recipients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.kint.2018.12.024DOI Listing
March 2019
1 Read

Parathyroid Diseases.

Authors:
Scott A Sullivan

Clin Obstet Gynecol 2019 Mar 27. Epub 2019 Mar 27.

Maternal-Fetal Medicine, Medical University of South Carolina, Charleston, South Carolina.

Although uncommon in pregnancy, parathyroid dysfunction may produce significant perinatal and maternal morbidity and mortality. The prevalence of hyperparathyroidism is 0.5%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/GRF.0000000000000447DOI Listing
March 2019
1 Read

Oxidative stress in proliferative lesions of parathyroid gland.

Pol Przegl Chir 2018 Nov;91(1):29-34

Medical University of Silesia, Katowice, Poland School of Medicine with the Division of Dentistry in Zabrze Department of General and Endocrine Surgery.

Background: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders and defined as excessive secretion of parathormone. PHPT is a risk factor of several cardiovascular diseases, which could be caused by alterations in oxidant-antioxidant balance.

Materials And Methods: Blood serum collected from 52 consecutive patients with PHPT treated surgically constituted our study material, whereas 36 healthy volunteers were our control group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5604/01.3001.0012.7258DOI Listing
November 2018
1 Read

[A case report of acute pancreatitis caused by primary hyperparathyroidism during pregnancy].

Authors:
C W Zhao J Chen

Zhonghua Nei Ke Za Zhi 2019 Apr;58(4):314-316

Department of Gastroenterology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2019.04.016DOI Listing
April 2019
1 Read

Predictors of nephrolithiasis, osteoporosis and mortality in primary hyperparathyroidism.

J Clin Endocrinol Metab 2019 Mar 27. Epub 2019 Mar 27.

Edinburgh Centre for Endocrinology and Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK.

Context: Primary Hyperparathyroidism (PHPT) has a prevalence of 0.86% and is associated with increased risk of nephrolithiasis and osteoporosis. PHPT may also be associated with an increased risk of cardiovascular disease and mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-02483DOI Listing
March 2019
2 Reads

Attenuated Dentin Matrix Protein 1 Enhances Fibroblast Growth Factor 23 in Calvaria in Primary Hyperparathyroidism Model.

Endocrinology 2019 Mar 27. Epub 2019 Mar 27.

Osaka City University Graduate School of Medicine, Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka, Japan.

Fibroblast growth factor 23 (FGF23) secretion is facilitated by parathyroid hormone (PTH), particularly in hyperparathyroidism. PTH also attenuates dentin matrix protein 1 (DMP1), which is produced by osteocytes to contribute to bone mineralization and suppress FGF23 expression. Nevertheless, it remains unknown whether attenuated DMP1 affects FGF23 expression in hyperparathyroidism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2019-00017DOI Listing

Serum PTH reference values in an adult Brazilian population: implications for the diagnosis of hyperparathyroidism.

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brasil.

Objective: To define serum parathyroid hormone (PTH) reference values in carefully selected subjects following the recommended pre-analytical guidelines.

Subjects And Methods: First, 676 adults who would be submitted to thyroidectomy were evaluated. Patients using interfering medications or with malabsorption syndrome, hypomagnesemia, hyper- or hypophosphatemia, hypo- or hypercalcemia, 25-hydroxyvitamin D < 30 ng/dL, estimated glomerular filtration rate < 60 mL/min/1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.20945/2359-3997000000117DOI Listing
March 2019
1 Read

Challenges in the treatment of parathyroid carcinoma: a case report.

Hormones (Athens) 2019 Mar 23. Epub 2019 Mar 23.

Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Hospital, University of Catania, Via Palermo 636, 95122, Catania, Italy.

Introduction: Parathyroid carcinoma (PC) is a rare neoplasm with a high rate of recurrence and an indolent course. It is frequently functional, causing nearly 1% of the cases of primary hyperparathyroidism (HPT), and in some cases, it may be complicated by brown tumors, mimicking bone metastases. Synchronous parathyroid and papillary thyroid carcinomas are rare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s42000-019-00104-wDOI Listing
March 2019
2 Reads

Could the Less-Than Subtotal Parathyroidectomy Be an Option for Treating Young Patients With Multiple Endocrine Neoplasia Type 1-Related Hyperparathyroidism?

Front Endocrinol (Lausanne) 2019 7;10:123. Epub 2019 Mar 7.

Endocrine Genetics Unit (LIM-25), Endocrinology Division, Hospital das Clinicas, University of Sao Paulo School of Medicine, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

The surgical treatment of primary hyperparathyroidism (HPT) in patients with multiple endocrine neoplasia type 1 (MEN1) has evolved due the concern of permanent hypoparathyroidism. As the diagnosis has increased, the extent of operation has decreased. Most MEN1 patients requiring parathyroidectomy are younger than 50 years and they pose a difficult balance to achieve between persistent HPT and life-long hypoparathyroidism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2019.00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417394PMC
March 2019
2 Reads

Morning blood pressure surge increases in patients with hypertensive primary hyperparathyroidism and is independently associated with serum calcium level.

Clin Exp Hypertens 2019 Mar 21:1-7. Epub 2019 Mar 21.

b Department of Cardiology , University of Health Sciences - Adana Health Practices and Research Center , Adana , Turkey.

Introduction: There is not enough data on the effects of primary hyperparathyroidism (pHPT) on morning blood pressure surge (MBPS) in the literature. We aimed to determine whether there was any change in MBPS value in patients with hypertensive pHPT and to determine the parameters related to MBPS.

Method: 80 patients with newly diagnosed pHPT with hypertension (HT) and 80 controls with newly diagnosed hypertension were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10641963.2019.1590388DOI Listing
March 2019
1 Read

A Novel Mutation of the Calcium-Sensing Receptor Gene Causing Familial Hypocalciuric Hypercalcemia Complicates Medical Followup after Roux-en-Y Gastric Bypass: A Case Report and a Summary of Mutations Found in the Same Hospital Laboratory.

Case Rep Endocrinol 2019 13;2019:9468252. Epub 2019 Feb 13.

Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Denmark.

Heterozygous inactivating mutations in the calcium-sensing receptor (CaSR) gene are known to cause familial hypocalciuric hypercalcemia (FHH), usually a benign form of hypercalcemia without symptoms of a disrupted calcium homeostasis. FHH can be mistaken for the more common primary hyperparathyroidism (PHPT), for which surgical treatment may be needed. We describe a case of a 36-year-old woman with hypercalcemia and elevated PTH, initially suspected of having PHPT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/9468252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393866PMC
February 2019
1 Read

US-guided microwave ablation for primary hyperparathyroidism: a safety and efficacy study.

Eur Radiol 2019 Mar 19. Epub 2019 Mar 19.

Department of Endocrinology and Metabolism/Diabetes Care & Research Center, Nanjing Medical University Affiliated Geriatric Hospital/Jiangsu Province Geriatric Hospital, Jiangsu Province Official Hospital/Jiangsu Province Insititute of Geriatrics, 30 Luojia Road, Nanjing, 210024, Jiangsu, China.

Objectives: To evaluate the safety and efficacy of microwave ablation (MWA) with the assistance of continuous cool saline injection (CCSI) in patients with primary hyperparathyroidism (PHPT).

Methods: Between November 1, 2014, and February 29, 2016, 22 patients with PHPT were enrolled and treated with ultrasound-guided MWA assisted by CCSI. The levels of parathyroid hormone (PTH) and serum calcium were recorded before and after the MWA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-019-06078-yDOI Listing
March 2019
4 Reads

The role of F18-fluorocholine positron emission tomography/magnetic resonance imaging in localizing parathyroid adenomas.

Eur Arch Otorhinolaryngol 2019 May 16;276(5):1509-1516. Epub 2019 Mar 16.

Department of Nuclear Medicine, Assuta Medical Center, Faculty of Medicine, Tel Aviv. Affiliated with Ben Gurion University, Beersheba, Israel.

Purpose: Preoperative localization of a parathyroid adenoma is usually obtained by the combination of ultrasound and scintigraphy with technetium-99m methoxyisobutylisonitrile. We evaluated the role of F18-fluorocholine in neck positron emission tomography/magnetic resonance imaging as a novel tool for localizing parathyroid adenomas.

Methods: Patients with primary hyperparathyroidism were recruited from February 2016 to August 2017 and F18-fluorocholine positron emission tomography/magnetic resonance imaging was performed to localize the parathyroid adenoma prior to surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00405-019-05301-2DOI Listing
May 2019
1 Read

Novel PET tracers: added value for endocrine disorders.

Endocrine 2019 Apr 14;64(1):14-30. Epub 2019 Mar 14.

Sorbonne University, Nuclear Medicine Department, Pitié-Salpêtrière Hospital, 47-83 Bd de l'Hôpital, 75013, Paris, France.

Nuclear medicine has been implicated in the diagnosis and treatment of endocrine disorders for several decades. With recent development of PET tracers, functional imaging now plays a major role in endocrine tumors enabling with high performance to their localization, characterization, and staging. Besides F-FDG, which may be used in the management and follow-up of endocrine tumors, new tracers have emerged, such as F-DOPA for neuroendocrine tumors (NETs) (medullary thyroid carcinoma, pheochromocytomas and paragangliomas and well-differentiated NETs originating from the midgut) and F-Choline in the field of primary hyperparathyroidism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12020-019-01895-zDOI Listing
April 2019
2 Reads

Fortuitous discovery of non-fluorocholine-fixing papillary carcinoma of vesicular variant of the thyroid.

Eur Arch Otorhinolaryngol 2019 May 14;276(5):1541-1544. Epub 2019 Mar 14.

Centre hospitalo-universitaire de Nîmes, Service d'oto-rhino-laryngologie, Rue du Professeur Robert Debré, 30900, Nîmes, France.

Purpose: Characterization of thyroid nodules is crucial to propose surgical intervention for histological verification. Cervical ultrasound potentially combined with fine needle aspiration is recommended, and fluorocholine positron emission tomography (FCH-PET), commonly used in prostatic cancers, has been evaluated in the diagnosis of thyroid cancers in recent publications.

Methods: We present two cases of patients with multinodular thyroid and primary hyperparathyroidism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00405-019-05370-3DOI Listing
May 2019
1 Read

PTH Modulation by Aldosterone and Angiotensin II is Blunted in Hyperaldosteronism and Rescued by Adrenalectomy.

J Clin Endocrinol Metab 2019 Mar 13. Epub 2019 Mar 13.

Hypertension Unit, Department of Medicine -DIMED, University of Medicine of Padova, Padova, Italy.

Context: Accumulating evidences suggest a link between adrenocortical zona glomerulosa and parathyroid gland through mechanisms that remain unexplored.

Objectives: To test the hypothesis that in vivo Angiotensin (Ang) II blockade affects parathyroid hormone (PTH) secretion in hypertensive patients and that aldosterone and Ang II directly stimulate PTH secretion ex vivo.

Design And Setting: We investigated the changes of serum PTH levels induced by oral captopril (50 mg) administration in patients with primary essential hypertension (EH) and with primary aldosteronism (PA) due to bilateral adrenal hyperplasia (BAH) or to aldosterone-producing adenoma (APA), the latter before and after adrenalectomy. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
Publisher Site
http://dx.doi.org/10.1210/jc.2019-00143DOI Listing
March 2019
12 Reads

Trabecular Bone Score, Bone Mineral Density and Bone Markers in Patients with Primary Hyperparathyroidism 2 Years After Parathyroidectomy.

Horm Metab Res 2019 Mar 12;51(3):186-190. Epub 2019 Mar 12.

Endocrinology and Nutrition Department, 12 de Octubre University Hospital, Madrid, Spain.

Following a parathyroidectomy there is a bone mineral density (BMD) improvement in patients with primary hyperparathyroidism. However, data of bone microarchitecture are scarce. Trabecular bone score (TBS) estimates bone microarchitecture and could provide valuable information in those patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0850-8679DOI Listing
March 2019
1 Read

Effect of Parathyroidectomy on cardiovascular risk factors in primary hyperparathyroidism: A randomised clinical trial.

J Clin Endocrinol Metab 2019 Mar 12. Epub 2019 Mar 12.

Department of Clinical Medicine, Aarhus University and Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark.

Context: It remains unclear whether risk of cardiovascular diseases is increased in patients with mild (˂1.45 mmol/l) to moderate (≥1.45-1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-02456DOI Listing
March 2019
1 Read

One-year safety and efficacy of intravenous etelcalcetide in patients on hemodialysis with secondary hyperparathyroidism.

Nephrol Dial Transplant 2019 Mar 11. Epub 2019 Mar 11.

Denver Nephrology, Denver, CO, USA.

Background: Secondary hyperparathyroidism (sHPT), a common complication of chronic kidney disease, is characterized by elevated serum parathyroid hormone (PTH). Etelcalcetide is an intravenous calcimimetic that increases sensitivity of the calcium-sensing receptor to calcium and decreases PTH secretion. This open-label extension (OLE) trial evaluated the long-term effects of etelcalcetide for sHPT treatment in patients receiving hemodialysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ndt/gfz039DOI Listing

Parathyroid adenoma presenting with multiple Brown tumors in an adolescent patient.

North Clin Istanb 2018 9;5(4):361-364. Epub 2018 Aug 9.

Department of Radiology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.

Parathyroid glands are endocrine glands that secrete parathyroid hormone (PTH) and regulate calcium-phosphor metabolism. The overexpression of PTH is called hyperparathyroidism (HPT), and is classified as primary, secondary, and tertiary. Primer HPT (PHPT) is the most common cause of parathyroid adenomas (80%-85%). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14744/nci.2018.35693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371999PMC
August 2018
1 Read

Changes to the frequency and appropriateness of vitamin D testing after the introduction of new Medicare criteria for rebates in Australian general practice: evidence from 1.5 million patients in the NPS MedicineInsight database.

BMJ Open 2019 Mar 8;9(3):e024797. Epub 2019 Mar 8.

Discipline of General Practice, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

Objectives: To assess changes in the frequency of vitamin D testing and detection of moderate/severe vitamin D deficiency (<30 nmol/L) among adults after the introduction of new Medicare Benefits Schedule (MBS) rebate criteria (November 2014), and their relationship to sociodemographic and clinical characteristics.

Design: Dynamic (open) cohort study SETTING: Primary care PARTICIPANTS: About 1.5 million 'active' patients aged 18+ years visiting a general practitioner and included in the National Prescribing Service MedicineInsight database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-024797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429877PMC
March 2019
1 Read