12,769 results match your criteria Hyperparathyroidism Primary

Primary familial brain calcification with mild phenotype due to a new PDGFB mutation.

Neurol Sci 2022 Jun 24. Epub 2022 Jun 24.

Department of Medical, Surgical and Neurological Sciences, Unit of Neurology and Neurometabolic Diseases, University of Siena, Viale Bracci 2, 53100, Siena, Italy.

Introduction: Primary familial brain calcification (PFBC) is a rare neurodegenerative disorder that presents cognitive and movement impairment. To diagnose PFBC, both brain calcium accumulations visible at computed tomography (CT) and autosomal dominant or recessive inherited genetic mutation(s) in one of the known genes have to be detected. We describe the case of a female patient aging 62, who presents marked calcifications at brain CT, not due to vitamin D deficiency. Read More

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Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):493-497

University of Sharjah, College of Medicine, Clinical Sciences Department, Sharjah, United Arab Emirates.

Context: Primary hyperparathyroidism related hypercalcemic crisis (PHHC) is a condition that may result in fetal course. So, the early diagnosis and treatment of these patients are important.

Objective: This study aimed to investigate the clinical features for hypercalcemic crisis (HC) by comparing the groups with and without primary hyperparathyroidism related calcemic crisis. Read More

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Atypical parathyroid adenoma: Series of two consecutive cases from a tertiary care hospital in Qatar.

Int J Surg Case Rep 2022 Jun 10;96:107296. Epub 2022 Jun 10.

Department of General Surgery, Hamad General Hospital, Doha, Qatar. Electronic address:

Introduction: Atypical parathyroid adenomas (APA) are an uncommon cause of hypercalcemia and comprise a minority of parathyroid adenomas.

Presentation Of Cases: Case 1 - Egyptian male, 48 years old with history of type 2 diabetes mellitus, incidentally discovered increased serum of calcium level on routine investigation, was diagnosed as PHPT, US and MIBI scan showed large left inferior parathyroid adenoma, focused exploration and excision of the APA was undertaken, histopathology confirmed APA. Case 2 - Egyptian male, 60 years old, cardiac patient with history of diabetes, hypertension and multiple cardiac interventions, had nausea, vomiting, constipation abdominal pain, polyuria, polydipsia, and history of passing renal stones, hypercalcemia workup showed primary hyperparathyroidism (PHPT), MIBI was negative and SPECT scan suggested right inferior parathyroid adenoma, focused exploration and excision of the APA was undertaken, histopathology confirmed APA. Read More

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Multidetector-Row CT Findings in Dogs with Different Primary Parathyroid Gland Diseases.

Vet Sci 2022 Jun 6;9(6). Epub 2022 Jun 6.

Diagnostic and Interventional Radiology Division, San Marco Veterinary Clinic and Laboratory, 35030 Veggiano, Italy.

Primary hyperparathyroidism in dogs is a possibly life-threatening condition, characterized by the excess of parathyroid hormone (PTH) secretion, which leads to an increase in serum ionized calcium level. The utility of computed tomography (CT) in the detection and characterization of parathyroid diseases in dogs has not been assessed to date. Therefore, the aim of this study was to describe the use of multidetector-row CT (MDCT) for the diagnosis of parathyroid disease in dogs. Read More

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Giant cystic parathyroid adenoma: two case reports and a literature review.

J Int Med Res 2022 Jun;50(6):3000605221106419

Department of Endocrinology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, P.R. China.

An uncommon cause of primary hyperparathyroidism is a cystic parathyroid adenoma. This paper describes two patients with hypercalcemia and right knee disease. Their serum calcium concentration was high, phosphorus concentration was low, and parathyroid hormone (PTH) concentration was high. Read More

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Acta Clin Croat 2021 Dec;60(4):617-626

1Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 2University of Applied Health Sciences, Zagreb, Croatia; 3Department of Radiology and Nuclear Medicine, PET/CT Center, Medikol Polyclinic, Zagreb, Croatia; 4Department of Nuclear Medicine and Radiology, Martini Hospital, Groningen, The Netherlands; 5Department of Surgery, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 6School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

The bone health guidelines for breast cancer (BC) patients recommend bone mineral density (BMD) testing. Patients with low BMD and elevated serum calcium levels (SCLs) are further evaluated for primary hyperparathyroidism (PHPT). We aimed to determine the prevalence of PHPT in treated BC patients with low BMD and analyze the association of SCLs with histopathologic tumor features and cancer treatment. Read More

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December 2021

A multi-institutional study evaluating and describing atypical parathyroid tumors discovered after parathyroidectomy.

Laryngoscope Investig Otolaryngol 2022 Jun 19;7(3):901-905. Epub 2022 May 19.

Department of Otolaryngology - Head and Neck Surgery University of Cincinnati College of Medicine Cincinnati Ohio USA.

Objective: To describe common intraoperative and pathologic findings of atypical parathyroid tumors (APTs) and evaluate clinical outcomes in patients undergoing parathyroidectomy.

Methods: In this multi-institutional retrospective case series, data were collected from patients who underwent parathyroidectomy from 2000 to 2018 from three tertiary care institutions. APTs were defined according to the AJCC eighth edition guidelines and retrospective chart review was performed to evaluate the incidence of recurrent laryngeal nerve injury, recurrence of disease, and disease-specific mortality. Read More

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Ectopic Pleural Parathyroid Adenoma Causing Recurrent Primary Hyperparathyroidism.

Cureus 2022 May 18;14(5):e25101. Epub 2022 May 18.

Endocrinology, Diabetes and Metabolism, Minneapolis Veterans Affairs Health Care System, Minneapolis, USA.

Ectopic parathyroid glands can cause primary hyperparathyroidism (PHPT) in up to 16% of cases. These can lead to recurrent/persistent PHPT, and multiple cases have been described in the literature. We present a case of a pleural parathyroid adenoma leading to persistent PHPT. Read More

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A case of familial hypocalciuric hypercalcemia type 1 due to CASR p.Pro55Leu mutation.

BMC Endocr Disord 2022 Jun 22;22(1):164. Epub 2022 Jun 22.

Department of Diabetes, Endocrinology and Metabolism/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.

Background: Familial hypocalciuric hypercalcemia (FHH) is a rare autosomal dominant disease, which requires differential diagnosis from relatively common primary hyperparathyroidism (PHPT) in order to avoid unnecessary surgery.

Case Presentation: A 16-year-old female had been followed by the department of psychosomatic medicine at our institution. Throughout the follow-up period, her plasma calcium levels were high, plasma Pi levels were relatively low, and plasma intact PTH was relatively high. Read More

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Using QCT to evaluate bone mineral and abdominal adipose changes in patients with primary hyperparathyroidism and comparing it to DXA for bone status assessment: a retrospective case-control study.

Ann Transl Med 2022 May;10(10):606

Department of Radiology, Ruijin Hospital Luwan Branch, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Background: Patients with primary hyperparathyroidism (PHPT) show changes in bone metabolism and adipose tissue, but the results are inconsistent. Quantitative computed tomography (QCT) was reported useful for detecting bone mineral and adipose tissue change, but information on the role of QCT in PHPT is limited. We aimed to explore the changes of lumbar bone mineral density (BMD) and abdominal adipose tissue in patients with PHPT using QCT based on existed CT images, and to assess the consistency between QCT and dual-energy X-ray absorptiometry (DXA) in assessing bone status. Read More

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Parathyroid Crisis as Presentation of Atypical Parathyroid Adenoma: Two Diagnostically Challenging Cases.

J Bone Metab 2022 May 31;29(2):133-140. Epub 2022 May 31.

Department of Endocrinology, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México, Mexico.

Atypical parathyroid adenoma (APA) is a rare cause of primary hyperparathyroidism (PHPT) and represents a diagnostic challenge since it is an intermediate form of parathyroid neoplasm of uncertain malignant potential with atypical histological features that require differential diagnosis of parathyroid carcinoma (PC). We present 2 cases of parathyroid crisis as a presentation of APA. The first case was that of a 56-year-old man with parathyroid crisis, constitutional syndrome, and anemia, with evidence of APA after en bloc resection, evolving with hungry bone syndrome after surgery and curation criteria at 6 months after parathyroidectomy (PTX). Read More

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Efficacy and safety of radiofrequency ablation versus parathyroidectomy for secondary hyperparathyroidism in dialysis patients: a single-center retrospective study.

Sci Rep 2022 Jun 18;12(1):10289. Epub 2022 Jun 18.

Urology and Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.

We compared the efficacy and safety of ultrasound (US)-guided radiofrequency ablation (RFA) and parathyroidectomy (PTX) for the treatment of secondary hyperparathyroidism (SHPT). In this single-center retrospective study, we divided patients into PTX (n = 53) and RFA (n = 47) groups. The primary outcome was the proportion of patients who achieved the target intact parathyroid hormone (iPTH) concentration range (≤ 300 pg/mL). Read More

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Are patients with limited English proficiency less likely to undergo parathyroidectomy for primary hyperparathyoidism?

Am J Surg 2022 Jun 8. Epub 2022 Jun 8.

Harvard Medical School, Boston, MA, USA; Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address:

Background: Despite meeting operative indications for primary hyperparathyroidism (PHPT), many patients never undergo parathyroidectomy. We hypothesized that patients with limited English proficiency (LEP) would be less likely to undergo parathyroidectomy than English-proficient (EP) patients.

Study Design: We retrospectively analyzed patients with PHPT from an institution-wide registry who met operative criteria between 2010 and 2018. Read More

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Case Report: Primary Hyperparathyroidism due to Posterior Mediastinal Parathyroid Adenoma With One-Year Follow-Up.

Front Surg 2022 31;9:893259. Epub 2022 May 31.

Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, China.

Ectopic parathyroid adenoma, though rare, is one of the causes of persistent hyperparathyroidism and recurrence of hyperparathyroidism. Ectopic parathyroid glands can be seen in thymus, thyroid, and mediastinum. However, ectopic parathyroid adenoma occurred in the posterior superior mediastinum is extremely rare. Read More

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Elevated parathyroid hormone one year after kidney transplantation is an independent risk factor for graft loss even without hypercalcemia.

BMC Nephrol 2022 Jun 17;23(1):212. Epub 2022 Jun 17.

Department of Transplant and Endocrine Surgery, Japanese Red Cross Nagoya Daini Hospital, 2-9 Myoken-cho, Showa-ku, Nagoya, Aichi, 4668650, Japan.

Background: Hypercalcemic hyperparathyroidism has been associated with poor outcomes after kidney transplantation (KTx). However, the clinical implications of normocalcemic hyperparathyroidism after KTx are unclear. This retrospective cohort study attempted to identify these implications. Read More

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Predicting ultrasound-guided thermal ablation benefit in primary hyperparathyroidism.

Eur Radiol 2022 Jun 16. Epub 2022 Jun 16.

Department of Interventional Ultrasound, The Fifth Medical Center, Chinese PLA General Hospital, NO. 28 Fuxing Road, Beijing, 100853, China.

Objectives: Ultrasound (US)-guided thermal ablation for primary hyperparathyroidism (PHPT) is a relatively novel minimally invasive treatment. The recurrence rate after ablation is between 10 and 15%. The characteristics of patients who can benefit from thermal ablation therapy are not clear yet. Read More

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Accuracy of Parathyroid Adenoma Localization by Preoperative Ultrasound and Sestamibi in 1089 Patients with Primary Hyperparathyroidism.

World J Surg 2022 Jun 15. Epub 2022 Jun 15.

Department of Endocrine Surgery, Schön Klinik Hamburg-Eilbek, Dehnhaide 120, 22081, Hamburg, Germany.

Background: Primary hyperparathyroidism (pHPT) is well treatable surgically. Sonography (US) and sestamibi scintigraphy (MIBI) are used routinely, but it is unclear how valuable they are in determining Parathyroid glands' different locations. This study aimed to evaluate the prognostic value of US and MIBI in relation to the different localization of parathyroid adenomas in one of the largest study populations analyzed to date. Read More

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Preoperative inflammatory markers for predicting parathyroid carcinoma.

Endocr Connect 2022 Jun 1. Epub 2022 Jun 1.

K Ito, Department of Surgery, Ito Hospital, Tokyo, Japan.

Objective: Parathyroid carcinoma is a rare tumor among parathyroid tumors. Aspiration cytology and needle biopsy are generally not recommended for diagnostic purposes because they cause dissemination. Therefore, it is commonly diagnosed by postoperative histopathological examination. Read More

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Analysis of 55 patients with multiple endocrine neoplasia type 1-associated insulinoma from a single center in China.

Orphanet J Rare Dis 2022 06 13;17(1):219. Epub 2022 Jun 13.

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Objective: To investigate the clinical characteristics of patients with multiple endocrine neoplasia type 1 (MEN1)-related insulinoma and their relationship with specific biochemical changes and to summarize the features of treatment options for the Chinese population with this disease and the impact on long-term prognosis.

Methods: "MEN1" and "insulinoma" were used when searching the Peking Union Medical College Hospital (PUMCH) medical record retrieval system to obtain clinical information about patients. We identified patients diagnosed with MEN1-associated insulinoma based on endocrinological, radiological, and pathological examinations, and subsequently analyzed their clinical data. Read More

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Lipoadenoma of the parathyroid: characteristics of a rare cause of hyperparathyroidism.

Endocr J 2022 Jun 10. Epub 2022 Jun 10.

Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan.

Parathyroid Lipoadenoma (PLA) contains abundant mature adipose tissue and is a rare cause of hyperparathyroidism. This study aimed to investigate the clinical features of PLA in nine patients with primary hyperparathyroidism, including two men and seven women, with ages ranging from 45-84 years (median 60 years). PLA accounted for 0. Read More

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Arterial Stiffness in Thyroid and Parathyroid Disease: A Review of Clinical Studies.

J Clin Med 2022 Jun 1;11(11). Epub 2022 Jun 1.

Department of Medicine, Surgery and Health Sciences, University of Trieste, 34149 Trieste, Italy.

Growing evidence shows that arterial stiffness measurement provides important prognostic information and improves clinical stratification of cardiovascular risk. Thyroid and parathyroid diseases are endocrine diseases with a relevant cardiovascular burden. The objective of this review was to consider the relationship between arterial stiffness and thyroid and parathyroid diseases in human clinical studies. Read More

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Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism.

BMC Endocr Disord 2022 Jun 9;22(1):156. Epub 2022 Jun 9.

Department of General Surgery, China-Japan Friendship Hospital, 100029, Beijing, China.

Objective: To study the protein and mRNA expressions of regulator of G-protein signaling 5 (RGS5) in the pathogenesis of hyperparathyroidism.

Methods: The expression of RGS5 protein in 20 primary hyperparathyroidism (PHPT), 31 secondary hyperparathyroidism (SHPT), and 20 control cases were studied by immunohistochemistry (IHC). The expression of RGS5 mRNA in 15 PHPT, 102 SHPT, and 7 normal parathyroid tissue were measured by quantitative real-time PCR (qRT-PCR) method. Read More

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Quality Indicators for Primary Hyperparathyroidism-Reply.

JAMA Otolaryngol Head Neck Surg 2022 Jun 9. Epub 2022 Jun 9.

University Health Network, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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Quality Indicators for Primary Hyperparathyroidism.

Tam-Lin Chow

JAMA Otolaryngol Head Neck Surg 2022 Jun 9. Epub 2022 Jun 9.

Head and Neck Division, Department of Surgery, United Christian Hospital, Hong Kong.

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Impact of curative parathyroidectomy on left ventricular functions assessed with 2D ECHO and MUGA study.

Turk J Surg 2021 Dec 31;37(4):336-341. Epub 2021 Dec 31.

Department of General Surgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Objectives: Primary hyperparathyroidism (PHPT) is associated with increased cardiovascular morbidity and mortality with inconsistent results on the reversibility of cardiovascular changes after parathyroidectomy (PTx). The present study was undertaken to evaluate both structural and functional cardiac changes and their reversal after PTx in patients with PHPT.

Material And Methods: Thirty patients of symptomatic PHPT without cardiovascular risk factors were evaluated prospectively by means of 2D echocar- diography (ECHO) and Multigated Acquisition (MUGA) study before surgery and six months after curative parahyroidectomy. Read More

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December 2021

A Case of Acute Adrenal Insufficiency: A Rare but Possible Cause of Hypercalcemia.

Cureus 2022 May 5;14(5):e24752. Epub 2022 May 5.

Department of Endocrinology, Diabetology, Metabolic Diseases and Nutrition, Hassan II University Hospital, Fez, MAR.

A 30-year-old woman presented with a 15-day history of epigastric pain, nausea, vomiting, asthenia, and weight loss. On admission, hypercalcemia was reported with a negative etiologic workup (including no primary hyperparathyroidism, malignancy, or vitamin D toxicity). Fluid replacement did not improve her hypercalcemia. Read More

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Fine-tuned continuous renal replacement therapy with calcium-free dialysate to manage severe hypercalcemia refractory to medical and intermittent hemodialysis.

Eur J Med Res 2022 Jun 8;27(1):89. Epub 2022 Jun 8.

Service of Nephrology, Hôpital du Valais, Avenue Grand-Champsec 80, 1951, Sion, Switzerland.

Malignancy-related hypercalcemia is a leading cause of hypercalcemia among hospitalized patients that carries poor prognosis. Parathyroid carcinoma is a rare form of primary hyperparathyroidism that may be associated with PTH dependent hypercalcemia. Severe hypercalcemia is life-threatening and may require management in an intensive care unit by means of medical therapy consisting of volume expansion, loop diuretics, cinacalcet, calcitonin and bisphosphonates. Read More

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Primary hyperparathyroidism in Saudi Arabia revisited: a multi-centre observational study.

BMC Endocr Disord 2022 Jun 9;22(1):155. Epub 2022 Jun 9.

Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.

Purpose: Primary hyperparathyroidism (PHPT) is a common cause of hypercalcemia and remains understudied within the Arabian population. The present study, the largest of its kind within the Gulf Cooperation Council (GCC) countries, aims to determine the demographics and clinical presentation of PHPT in Saudi Arabia.

Methods: In this multi-center retrospective study involving three tertiary hospitals in different geographic locations of Saudi Arabia namely, Riyadh, Al Ahsa and Jeddah, a total of 205 out of 243 confirmed PHPT cases aged 16 to 93 years old were included (N = 96 from Riyadh; N = 59 from Al Ahsa and N = 50 from Jeddah). Read More

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Long-Term Cure of Primary Hyperparathyroidism After Scan-Directed Parathyroidectomy: Outcomes from a UK Endocrine Surgery Unit.

Stan Sidhu

World J Surg 2022 Jun 7. Epub 2022 Jun 7.

Endocrine Surgery Unit, Royal North Shore Hospital and the University of Sydney, St Leonards, NSW, Australia.

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Primary hyperparathyroidism, a machine learning approach to identify multiglandular disease in patients with a single adenoma found at preoperative Sestamibi-SPECT/CT.

Eur J Endocrinol 2022 Jun 1. Epub 2022 Jun 1.

A Sanchez-Crespo, Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, 171 76, Sweden.

Objective: Successful preoperative image localisation of all parathyroid adenomas (PTA) in patients with primary hyperparathyroidism (pHPT) and multiglandular disease (MGD) remains challenging. We investigate whether a machine learning classifier (MLC) could predict the presence of overlooked PTA at preoperative localisation with 99mTc-Sestamibi-SPECT/CT in MGD-patients.

Design: Retrospective study from a single tertiary referral hospital initially including 349 patients with biochemically confirmed pHPT and cured after surgical parathyroidectomy. Read More

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