11,722 results match your criteria Hyperparathyroidism Primary


Endocrine Tumor Board: Ten Years' Experience of a Multidisciplinary Clinical Working Conference.

Perm J 2020 ;24

Department of Endocrinology, Kaiser Permanente, Pleasanton, CA (retired).

Introduction: Advances in specialized medical areas and updated clinical guidelines show a need for a focused approach for patients with specific disorders.

Objective: To describe a multidisciplinary tumor board for patients with endocrine tumors.

Methods: We established an endocrine tumor board at a large health maintenance organization and studied cases presented between September 2007 and August 2017. Read More

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http://dx.doi.org/10.7812/TPP/19.140DOI Listing
January 2020

Robotic-assisted parathyroidectomy and short-term outcomes: a systematic review of the literature.

J Robot Surg 2020 Jul 13. Epub 2020 Jul 13.

Laboratory of Experimental Surgery and Surgical Research, National and Kapodistrian University of Athens, Athens, Greece.

Minimal invasive techniques in endocrine surgery were lately adopted by surgical teams due to significant complications related to inadequate operative space and high risk of injuring crucial surrounding structures, such as vessels and nerves. Over the last years, technological improvements introduced robotic systems and approaches in endocrine surgery. Several case reports and series have described the safety and efficacy of these procedures such as robotic thyroidectomy and robotic parathyroidectomy. Read More

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http://dx.doi.org/10.1007/s11701-020-01119-xDOI Listing

Parathyroid gland hyperplasia associated with tuberculous granulomatous inflammation manifesting as primary hyperparathyroidism.

Med Mal Infect 2020 Jul 10. Epub 2020 Jul 10.

Otorhinolaryngology - Head and Neck Surgery Department, Complexo Hospitalario Universitario A Coruña (CHUAC), 15006, A Coruña, Galicia, Spain.

Objectives: Inflammatory disorders of the parathyroid gland are poorly defined. Only seven cases of granulomatous infection have been reported in the literature.

Patients And Methods: A 68-year-old woman presented with parathyroid hormone level at 277 pg/mL and calcium level at 10. Read More

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http://dx.doi.org/10.1016/j.medmal.2020.07.002DOI Listing

Parathyroidectomy Resolves Tooth Discoloration: A New Presenting Sign of Hyperparathyroidism?

Case Rep Dent 2020 10;2020:8281468. Epub 2020 May 10.

Department of Medicine DIMED-Clinica Medica 1-University of Padova, Via Giustiniani 2, 35128 Padova, Italy.

Introduction: We report the resolution of tooth discoloration following parathyroidectomy in an otherwise asymptomatic woman with primary hyperparathyroidism-associated hypercalcemia. . A 59-year-old Caucasian woman, diagnosed with primary hyperparathyroidism in 2011, nonsmoker with excellent overall oral health. Read More

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http://dx.doi.org/10.1155/2020/8281468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330640PMC

Undertreatment of primary hyperparathyroidism in a privately insured US population: Decreasing utilization of parathyroidectomy despite expanding surgical guidelines.

Surgery 2020 Jul 9. Epub 2020 Jul 9.

Department of Surgery, Stanford University School of Medicine, CA.

Background: Primary hyperparathyroidism is associated with substantial morbidity, including osteoporosis, nephrolithiasis, and chronic kidney disease. Parathyroidectomy can prevent these sequelae but is poorly utilized in many practice settings.

Methods: We performed a retrospective cohort study using the national Optum de-identified Clinformatics Data Mart Database. Read More

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http://dx.doi.org/10.1016/j.surg.2020.04.066DOI Listing

Single Center Experience in the Surgical Management of Primary Hyperparathyroidism.

Clin Exp Otorhinolaryngol 2020 Jul 11. Epub 2020 Jul 11.

Section of Endocrinology and Metabolism, Pendik Training and Research Hospital, Marmara University Medical Faculty, Istanbul, Turkey.

Objectives.: As calcium included as a part of routine laboratory screening early diagnosis of primary hyperparathyroidism (PHPT) has been increased. Surgical resection of parathyroid adenoma or hyperplasia still is the mainstay of the treatment for most PHPT patients. Read More

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http://dx.doi.org/10.21053/ceo.2019.01361DOI Listing

A Case of Hyperparathyroidism Which Developed After Resection of a Fibroblast Growth Factor 23-producing Tumor.

Intern Med 2020 Jul 7. Epub 2020 Jul 7.

First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

A 53-year-old woman presented with bone pain and was diagnosed with osteomalacia because of hypophosphatemia, hyperphosphatasemia, bone pain, and radiographic findings. Because her intact-fibroblast growth factor 23 (FGF23) levels were high and contrast-enhanced computed tomography revealed a mass in the anterior ethmoid sinus, FGF23-related osteomalacia was diagnosed. The tumor was resected, but she developed hypercalcemia and elevated blood parathyroid hormone (PTH) levels. Read More

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http://dx.doi.org/10.2169/internalmedicine.4412-19DOI Listing

Functional Analysis of Calcium-Sensing Receptor Variants Identified in Families Provisionally Diagnosed with Familial Hypocalciuric Hypercalcaemia.

Calcif Tissue Int 2020 Jul 8. Epub 2020 Jul 8.

Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Block C, Level 1, Hospital Avenue, Nedlands, WA, Australia.

Identification of variants in the calcium-sensing receptor (CASR) gene is an important means of distinguishing between familial hypocalciuric hypercalcaemia (FHH) and primary hyperparathyroidism. However, identification and bioinformatics analysis of genetic variants alone is now considered insufficient as definitive proof; additional functional assessment is required to diagnose FHH with certainty. We identified two novel variants, D433Y and C739Y, and one previously reported variant G509R in the CASR of four kindreds provisionally diagnosed with FHH and aimed to functionally characterise these variants to confirm the diagnosis. Read More

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http://dx.doi.org/10.1007/s00223-020-00715-1DOI Listing

Hypercalcemia caused by comorbid parathyroid adenoma and pulmonary tuberculosis.

CEN Case Rep 2020 Jul 6. Epub 2020 Jul 6.

Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan.

Hypercalcemia is usually secondary to one etiology, although two coexisting etiologies can rarely cause hypercalcemia. Here, we report a 47-year-old woman with hypercalcemia caused by comorbid parathyroid adenoma and pulmonary tuberculosis. Primary hyperparathyroidism is the most common cause of hypercalcemia. Read More

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http://dx.doi.org/10.1007/s13730-020-00509-2DOI Listing

How to manage osteoporosis before the age of 50.

Maturitas 2020 Aug 18;138:14-25. Epub 2020 May 18.

Department of Medicine, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.

This narrative review discusses several aspects of the management of osteoporosis in patients under 50 years of age. Peak bone mass is genetically determined but can also be affected by lifestyle factors. Puberty constitutes a vulnerable period. Read More

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http://dx.doi.org/10.1016/j.maturitas.2020.05.004DOI Listing
August 2020
2.942 Impact Factor

Cinacalcet and primary hyperparathyroidism: systematic review and meta regression.

Endocr Connect 2020 Jul 1. Epub 2020 Jul 1.

C Khoo, Medicine, NUS Yong Loo Lin School of Medicine, Singapore, 117597, Singapore.

Purpose: Primary hyperparathyroidism (PHPT) is common condition, affecting people of all ages and is mainly treated with parathyroidectomy. Cinacalcet has been widely used in secondary or tertiary hyperparathyroidism, but the use of cinacalcet in PHPT is less clear.

Methods: Searches were conducted in Medline and Embase for cinacalcet use in PHPT from induction to 10th April 2020. Read More

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http://dx.doi.org/10.1530/EC-20-0221DOI Listing

Effects of denosumab as compared with parathyroidectomy regarding calcium, renal, and bone involvement in osteoporotic patients with primary hyperparathyroidism.

Endocrine 2020 Jul 3. Epub 2020 Jul 3.

Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.

Purpose: To evaluate the effects of denosumab (Dmb) on calcium, renal, and bone involvement in osteoporotic patients with primary hyperparathyroidism (PHPT) and compare with those who underwent a parathyroidectomy (PTX) procedure.

Methods: This retrospective, longitudinal study included patients treated with Dmb (60 mg) once every 6 months (n = 19) and those who successfully underwent a PTX procedure (n = 19) corrected calcium (cCa), eGFR, bone mineral density (BMD) in the lumbar spine (LS), total hip (TH), and femoral neck (FN) and LS-trabecular bone score (TBS) changes at 1 year after beginning Dmb or undergoing PTX were measured.

Results: Dmb group had older age, and showed milder disease activity and lower eGFR as compared with PTX group. Read More

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http://dx.doi.org/10.1007/s12020-020-02401-6DOI Listing

Case Report: Familial Hypocalciuric Hypercalcaemia and Hashimoto's Thyroiditis.

Front Surg 2020 16;7:30. Epub 2020 Jun 16.

Department of Transplant and Endocrine Surgery, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.

Hypercalcaemia can be caused by many disorders. Primary hyperparathyroidism is the leading cause with parathyroidectomy being the definitive management. Familial hypocalciuric hypercalcaemia is a rarer cause in which resection of the parathyroid tissue does not result in normalized serum calcium. Read More

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http://dx.doi.org/10.3389/fsurg.2020.00030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308482PMC

Comprehensive treatment of rare multiple endocrine neoplasia type 1: A case report.

World J Clin Cases 2020 Jun;8(12):2647-2654

Department of Hepatobiliary, Hebei General Hospital, Shijiazhuang 050017, Hebei Province, China.

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary disorder caused by mutations of the gene. It is characterized by hyperparathyroidism and involves the pancreas, anterior pituitary, duodenum, and adrenal gland. Here, we report a 40-year-old male patient with MEN1 who first manifested as thymic carcinoid, then primary hyperparathyroidism and prolactinoma, and a decade later pancreatic neuroendocrine tumor. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i12.2647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322426PMC

Evaluation of Serum Level of FGF23 and 1,25(OH)D in Primary Hyperparathyroidism Patients Before and After Parathyroidectomy.

Int J Gen Med 2020 11;13:289-295. Epub 2020 Jun 11.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: Parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) play critical roles in phosphate homeostasis. To the best of our knowledge, there are limited data on the impact of FGF23 and PTH on serum calcium, 1,25(OH)D, and phosphate in patients with primary hyperparathyroidism (PHPT). We examined these parameters and their correlations in PHPT patients before and after parathyroidectomy (PTX). Read More

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http://dx.doi.org/10.2147/IJGM.S253246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295333PMC

Benefit of diverse surgical approach on short-term outcomes of MEN1-related hyperparathyroidism.

Sci Rep 2020 Jun 30;10(1):10634. Epub 2020 Jun 30.

Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Republic of Korea.

Surgical excision is the preferred treatment for multiple endocrine neoplasia type 1 (MEN1)-related primary hyperparathyroidism (PHPT), although controversy regarding the surgical strategy exists. We retrospectively investigated the short-term outcomes of PHPT by various surgical extents. Thirty-three patients who underwent parathyroidectomy due to MEN1-related PHPT at Yonsei Severance Hospital between 2005 and 2018 were included (age [mean ± SD], 43. Read More

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http://dx.doi.org/10.1038/s41598-020-67424-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326992PMC

F-Fluorocholine PET and Multiphase CT Integrated in Dual Modality PET/4D-CT for Preoperative Evaluation of Primary Hyperparathyroidism.

J Clin Med 2020 Jun 26;9(6). Epub 2020 Jun 26.

Nuclear Medicine and Molecular Imaging, ICANS-University Hospitals of Strasbourg, 67033 Strasbourg, France.

The present retrospective study evaluates the diagnostic value of integrated F-Fluorocholine positron emission tomography/four-dimensional contrast-enhanced computed tomography (F-FCH PET/4D-CT) as second-line imaging in preoperative work-up of primary hyperparathyroidism (pHPT), and compares F-FCH PET with 4D-CT. Patients with pHPT and negative/discordant first-line imaging addressed for integrated F-FCH PET/4D-CT were retrospectively selected. Sensitivity and detection rate (DR%) of F-FCH PET/CT, 4D-CT, and PET/4D-CT were calculated according to the per patient and per lesion analyses, and afterwards compared. Read More

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http://dx.doi.org/10.3390/jcm9062005DOI Listing

Giant parathyroid adenoma: a rare cause of primary hyperparathyroidism mimicking a carcinoma.

Endokrynol Pol 2020 Jun 29. Epub 2020 Jun 29.

Surgical Oncology, Garibaldi-Nesima Hospital, Via Palermo n° 636, 95122 Catania, Italy.

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http://dx.doi.org/10.5603/EP.a2020.0035DOI Listing

FGF23 and primary hyperparathyroidism: is there a link?

Endokrynol Pol 2020 Jun 29. Epub 2020 Jun 29.

Grigore. T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.

Introduction: Data regarding the role of FGF23 in primary hyperparathyroidism (PHPT) are scarce and discordant. Our study aimed at evaluating the prognostic impact of FGF23 upon the clinical and biochemical evolution of PHPT.

Materials And Methods: 42 patients with ages between 30 - 80 years diagnosed with PHPT caused by a sporadic, solitary parathyroid adenoma and referred to surgery (minimally invasive parathyroidectomy) were prospectively included in the study. Read More

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http://dx.doi.org/10.5603/EP.a2020.0030DOI Listing

Revisiting a Case of Parathyroid Adenoma With Bilateral Staghorn Calculus.

Cureus 2020 May 23;12(5):e8251. Epub 2020 May 23.

General Medicine, Government Medical College and Hospital, Chandigarh, IND.

Parathyroid gland adenoma is responsible for approximately 80%-85% cases of primary hyperparathyroidism. Although not much is diagnostic on clinical examination, the blood investigations of the patients reveal raised serum calcium and serum parathyroid hormone levels. We present a case of chronic kidney disease with bilateral staghorn calculi and a right parathyroid adenoma localized on ultrasonography. Read More

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http://dx.doi.org/10.7759/cureus.8251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308822PMC

Recurrent hyperparathyroidism due to parathyroid and pulmonary tumors showing features of parathyroid adenoma.

Radiol Case Rep 2020 Aug 18;15(8):1289-1294. Epub 2020 Jun 18.

Department of Pathology, St. Marianna University School of Medicine University Hosital, Kawasaki, Kanagawa, Japan.

We report on a case of recurrent primary hyperparathyroidism possibly caused by parathyroid adenocarcinoma metastasizing to the lung. A 46-year-old woman with a history of parathyroid adenoma, which was extirpated 8 years ago, presented with symptoms of primary hyperparathyroidism, and was found to have a parathyroid and a lung nodule in radiographic assessments. Resections of the tumors in the parathyroid gland as well as the lung were required to improve her condition, and in pathology, both tumors demonstrated benign features consistent with adenoma. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306540PMC

Spironolactone reduces biochemical markers of bone turnover in postmenopausal women with primary aldosteronism.

Endocrine 2020 Jun 27. Epub 2020 Jun 27.

Medizinische Klinik und Poliklinik IV, Klinikum der Universität, LMU München, Ziemssenstraße 1, 80336, Munich, Germany.

Context: Primary aldosteronism (PA) is the most frequent form of endocrine hypertension. Besides its deleterious impact on cardiovascular target organ damage, PA is considered to cause osteoporosis.

Patients And Methods: We assessed bone turnover in a subset of 36 postmenopausal women with PA. Read More

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http://dx.doi.org/10.1007/s12020-020-02348-8DOI Listing

Genotype of CDC73 germline mutation determines risk of parathyroid cancer.

Endocr Relat Cancer 2020 Jun 1. Epub 2020 Jun 1.

W Simonds, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases Metabolic Diseases Branch, Bethesda, 20892-1752, United States.

Mutation of the CDC73 gene, which encodes parafibromin, has been linked with parathyroid cancer. However, no correlation between genotypes of germline CDC73 mutations and the risk of parathyroid cancer has been known. In this study, subjects with germline CDC73 mutations were identified from the participants of two clinical protocols at National Institutes of Health (Discovery Cohort) and from the literature (Validation Cohort). Read More

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http://dx.doi.org/10.1530/ERC-20-0149DOI Listing

Hyperparathyroidism (primary) NICE guideline: diagnosis, assessment, and initial management.

Br J Gen Pract 2020 Jul 25;70(696):362-363. Epub 2020 Jun 25.

National Guideline Centre, Royal College of Physicians, London.

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http://dx.doi.org/10.3399/bjgp20X710717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319687PMC

Tyrosine Kinase Inhibitors' Newly Reported Endocrine Side Effect: Pazopanib-Induced Primary Adrenal Insufficiency in a Patient With Metastatic Renal Cell Cancer.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620936808

University of Arizona, Phoenix, AZ, USA.

Tyrosine kinase inhibitors (TKIs) have been used in the treatment of multiple types of cancer. Pazopanib is one of the TKIs and is considered a first-line treatment for adult patients with metastatic renal cell carcinoma. Many endocrine-related adverse effects have been noted with the use of TKIs including hypothyroidism, vitamin D deficiency, altered bone density, secondary hyperparathyroidism, abnormal glucose metabolism, gynecomastia, and hypogonadism. Read More

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http://dx.doi.org/10.1177/2324709620936808DOI Listing

Cinacalcet-Associated Resolution of Primary Hyperparathyroidism in a Patient With Normal Kidney Function.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620936836

Department of Medicine, Albany Medical College, Albany, NY, USA.

Cinacalcet use is associated with risk of hypocalcemia; however, this risk has been mostly demonstrated in patients with chronic kidney disease. In this article, we describe a case of a 59-year-old male with primary hyperparathyroidism (PHPT), hypercalciuria, osteopenia, and normal kidney function who was started on cinacalcet for the management of recurrent hypercalcemia following prior unsuccessful parathyroidectomy. Within 6 months following cinacalcet commencement, he developed symptomatic and biochemical hypocalcemia requiring discontinuation of the medication and initiation of calcium supplementation. Read More

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http://dx.doi.org/10.1177/2324709620936836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318811PMC

Imaging and Diagnostic Challenges in a Patient With Refractory Hypoglycemia Caused by Insulinomas Related to Multiple Endocrine Neoplasia Type 1.

Cureus 2020 May 20;12(5):e8208. Epub 2020 May 20.

Internal Medicine, University of Missouri Health Care, Columbia, USA.

Insulinoma is a rare neuroendocrine tumor. It may occur sporadically or as part of the genetic tumor syndrome multiple endocrine neoplasia type 1 (MEN1). Diagnosis is challenging because of the small size of insulin producing tumors that lead to hyperinsulinemia. Read More

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http://dx.doi.org/10.7759/cureus.8208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305576PMC

Multiple Uterine Leiomyomas in Multiple Endocrine Neoplasia Type 1 with a Novel MEN1 Gene Mutation.

J Hum Reprod Sci 2020 Jan-Mar;13(1):75-77. Epub 2020 Apr 7.

Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.

To report the clinical, hormonal, and genetic features of a female with multiple endocrine neoplasia type 1 (MEN1) with multiple uterine leiomyomas. The study was conducted at a tertiary care endocrinology unit. A 27-year-old female was diagnosed with prolactinoma, primary hyperparathyroidism (PHPT), and multiple uterine leiomyomas. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_42_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295258PMC

GERMLINE MUTATION SCREENING IN CHINESE PRIMARY HYPERPARATHYROIDISM PATIENTS.

Endocr Pract 2020 Jun 23. Epub 2020 Jun 23.

From: Key laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Glial cell missing 2 (GCM2), the critical regulator in the development of parathyroid glands, has been associated with the pathogenesis of primary hyperparathyroidism (PHPT). Relevant data in Chinese and other Asian populations are still lacking. This study aimed to screen the germline mutations of in Chinese PHPT patients. Read More

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http://dx.doi.org/10.4158/EP-2020-0132DOI Listing

Parathyroid carcinoma in a 13-year-old girl with a long-term survival.

Surg Case Rep 2020 Jun 22;6(1):145. Epub 2020 Jun 22.

Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, Japan.

Background: Parathyroid carcinoma as a cause of primary hyperparathyroidism in children is extremely rare. We report a case of parathyroid carcinoma which occurred in a 13-year-old girl who survived for more than 45 years after the first operation.

Case Presentation: A woman was admitted to our hospital for the treatment of recurrent parathyroid carcinoma in the neck. Read More

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http://dx.doi.org/10.1186/s40792-020-00914-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310022PMC

Combined versus subtraction-only technique in parathyroid scintigraphy: effect on scan interpretation.

Nucl Med Commun 2020 Jun 18. Epub 2020 Jun 18.

Node for Infection Imaging, Central Analytical Facilities, Stellenbosch University, Cape Town, South Africa.

Introduction: Parathyroidectomy is the choice of treatment for patients with primary and tertiary hyperparathyroidism. Scintigraphic, preoperative localization of hyperfunctioning parathyroid tissue depends on either a delayed washout technique, a subtraction technique, or a combination of the two. The rationale for adopting a combination approach is its presumed superior sensitivity, but there is limited evidence to support this strategy at the cost of patient inconvenience and impact on departmental workflows. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001239DOI Listing

Ectopic Parathyroid Adenoma of the Piriform Sinus on Parathyroid 4D-CT and 99mTc-MIBI SPECT/CT.

Clin Nucl Med 2020 Aug;45(8):e358-e359

From the Department of Radiology, New York Presbyterian Hospital/Columbia University Medical Center, New York, NY.

Ectopic parathyroid adenomas are a common cause of postsurgical persistent primary hyperparathyroidism. Our case highlights a patient with a negative bilateral 4-gland exploration with follow-up parathyroid 4-dimensional CT and Tc-MIBI SPECT/CT, yielding focal uptake in the right piriform sinus. Subsequent direct laryngoscopy revealed a mass in the piriform sinus, which was resected with surgical pathology yielding parathyroid adenoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003163DOI Listing

Preoperative Vitamin D Levels as a Predictor of Transient Hypocalcemia and Hypoparathyroidism After Parathyroidectomy.

Sci Rep 2020 Jun 18;10(1):9895. Epub 2020 Jun 18.

Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

Hypocalcemia is a common problem after parathyroidectomy and/or thyroidectomy. The complication may be transient or permanent. Most cases occur as a result of removal of the parathyroid glands or damage to the glands during neck surgery. Read More

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http://dx.doi.org/10.1038/s41598-020-66889-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303145PMC

When primary hyperparathyroidism comes as good news.

Endocrinol Diabetes Metab Case Rep 2020 Jun 4;2020. Epub 2020 Jun 4.

Department of Medicine and Surgery, Endocrine Unit, University of Insubria, Varese, Italy.

Summary: Brown tumors are osteoclastic, benign lesions characterized by fibrotic stroma, intense vascularization and multinucleated giant cells. They are the terminal expression of the bone remodelling process occurring in advanced hyperparathyroidism. Nowadays, due to earlier diagnosis, primary hyperparathyroidism keeps few of the classical manifestations and brown tumors are definitely unexpected. Read More

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http://dx.doi.org/10.1530/EDM-20-0046DOI Listing

Hypercalcemia in the Presence of an Ectopic Mediastinal Mass.

J Prim Care Community Health 2020 Jan-Dec;11:2150132720932411

Mayo Clinic, Rochester, MN, USA.

A 72-year-old gentleman who presented to the outpatient clinic for a preventive health appointment with symptoms of depression and fatigue was found to have persistent hypercalcemia on routine laboratory monitoring. Initial laboratory testing was consistent with primary hyperparathyroidism with elevation in parathyroid hormone and low vitamin D levels. Further imaging demonstrated an ectopic mediastinal parathyroid adenoma. Read More

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http://dx.doi.org/10.1177/2150132720932411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307481PMC

Minimally invasive parathyroidectomy using intraoperative ultrasonographic localization for primary hyperparathyroidism in pregnancy: report of two cases.

Turk J Surg 2019 Sep 23;35(3):231-235. Epub 2019 Sep 23.

Clinic of General Surgery, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.

Primary hyperparathyroidism (pHPT) in pregnancy is a rare entity associated with increased maternal and fetal mortality and morbidity. Diagnosis of pHPT is challenging in pregnancy. Approximately 80% of the cases are asymptomatic, while the most common symptoms are nausea, vomiting, polyuria, polydypsia, and cloudy vision in symptomatic patients. Read More

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http://dx.doi.org/10.5578/turkjsurg.4330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795229PMC
September 2019

Parathyroid Adenoma as a Rare Cause of Persistent Hypercalcemia in a Female with Polycythemia Vera.

Case Rep Oncol 2020 May-Aug;13(2):578-582. Epub 2020 May 26.

Hamad Medical Corporation, Doha, Qatar.

Polycythemia vera is one of the myeloproliferative neoplasms that is distinguished by the uncontrolled production of blood cells and an increased red cell mass due to acquired mutation. It has many complications and it might increase the risk of other tumors. However, it does not cause hypercalcemia and is rarely associated with parathyroid adenoma. Read More

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http://dx.doi.org/10.1159/000507362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275195PMC

Mimicry of surgical site infection - Case report.

Int J Surg Case Rep 2020 May 29;72:212-214. Epub 2020 May 29.

University Centre for Orthopaedics and Trauma Surgery, University Hospital Carl Gustav Carus Dresden and Faculty of Medicine of Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany. Electronic address:

Background Context: Calciphylaxis is a rare complication of secondary hyperparathyroidism caused by calcifications of small blood vessels in the skin and soft tissue. The disease occurs almost exclusively in patients with chronic kidney disease and has an incidence of approximately 50 cases per year in Germany [1].

Purpose: We present a case of a 61-year-old woman with calciphylaxis in connection with a primary knee endoprosthesis implantation. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298546PMC

Re-Operative Parathyroidectomy in Patients With Mild Primary Hyperparathyroidism.

J Surg Res 2020 Jun 16;255:130-134. Epub 2020 Jun 16.

Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address:

Background: Surgery is the definitive management of primary hyperparathyroidism and the only curative therapy. However, many surgeons are hesitant to operate on individuals with mild primary hyperparathyroidism, with an even greater reluctance to operate on those who underwent a previous parathyroidectomy. We hypothesize that patients with mild primary hyperparathyroidism who undergo a re-operation have equivalent outcomes compared with those who undergo a first-time (FT) operation. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.043DOI Listing

Familial Hypocalciuric Hypercalcemia in Pregnancy: Diagnostic Pitfalls.

JBMR Plus 2020 Jun 27;4(6):e10362. Epub 2020 Apr 27.

Department of Endocrinology Monash Health Melbourne Australia.

Familial hypocalciuric hypercalcemia (FHH) is a group of autosomal dominant disorders caused by dysfunction of the calcium sensing receptor (CaSR) and its downstream signaling proteins, leading to generally asymptomatic hypercalcemia. During pregnancy, distinguishing FHH from primary hyperparathyroidism (PHPT) is important, as the latter is associated with adverse outcomes and can be treated surgically during pregnancy, whereas the former is benign. This case report highlights the difficulties in diagnosing FHH during pregnancy. Read More

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http://dx.doi.org/10.1002/jbm4.10362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285754PMC

Mutational Analysis of Parathyroid Adenomas.

JBMR Plus 2020 Jun 13;4(6):e10360. Epub 2020 Apr 13.

Center for Molecular Oncology University of Connecticut School of Medicine Farmington CT USA.

Benign parathyroid adenoma is the most common cause of primary hyperparathyroidism, whereas malignant parathyroid carcinoma is exceedingly rare. Distinguishing parathyroid carcinoma from benign adenoma is often difficult, and may be considerably delayed even after surgical resection until the rigorous diagnostic criteria of local invasion of surrounding tissues and/or distant metastases are fulfilled. Thus, new insights into their respective molecular bases may potentially aid in earlier diagnostic discrimination between the two, as well as informing new directions for treatment. Read More

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http://dx.doi.org/10.1002/jbm4.10360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285753PMC

Otoconia degeneration as a consequence of primary hyperparathyroidism.

Med Hypotheses 2020 Jun 7;144:109982. Epub 2020 Jun 7.

Department of Surgery, Division of Otolaryngology, Head and Neck Surgery, University of Connecticut Health, 263 Farmington Avenue, Farmington, CT 06030, USA. Electronic address:

Primary hyperparathyroidism (PHPT) is a common endocrine condition which disrupts physiologic calcium regulation. PHPT causes persistent hypercalcemia via the elevated and constant secretion of parathyroid hormone. Due to the effects of parathyroid hormone on target organs such as the bones, kidneys and gastrointestinal tract, untreated PHPT can lead to complications such as decreased bone mineral density, nephrolithiasis, and chronic abdominal pain, respectively. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109982DOI Listing

Ultrasound dye-assisted parathyroidectomy (USDAP): Experience of a tertiary center.

Am J Otolaryngol 2020 May 29:102558. Epub 2020 May 29.

Department of Otorhinolaryngology and Head and Neck Surgery, European Institute of Oncology, IRCCS, Via Ripamonti 435, 20141 Milan, Italy.

Background: Primary hyperparathyroidism is primarily caused by parathyroid adenoma, followed by hyperplasia and parathyroid carcinoma. In the era of minimally invasive, targeted parathyroidectomy, the main challenge remains that of distinguishing intraoperatively pathological parathyroid from normal glands and peri-thyroid fat tissue. The aim of this study is to evaluate the surgical outcomes of a novel minimally invasive technique called ultrasound-guided dye-assisted parathyroidectomy (USDAP). Read More

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http://dx.doi.org/10.1016/j.amjoto.2020.102558DOI Listing

OCCULT PRIMARY HYPERPARATHYROIDISM: A CASE REPORT AND REVIEW OF PARATHYROID ULTRASONOGRAPHY.

AACE Clin Case Rep 2020 May-Jun;6(3):e127-e131. Epub 2020 May 11.

Objective: To discuss the diagnosis and management of occult primary hyperparathyroidism.

Methods: We present the biochemical and radiologic evaluation, treatment, and outcome of a woman with occult primary hyperparathyroidism which presented as an unusual neck mass on ultrasound. We also present a relevant literature review. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282275PMC

Managing common endocrine disorders amid COVID-19 pandemic.

Diabetes Metab Syndr 2020 Jun 4;14(5):767-771. Epub 2020 Jun 4.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. Electronic address:

Background And Aims: The novel coronavirus disease (COVID-19) pandemic and the resulting nationwide lockdowns have posed a major challenge to the management of pre-existing and newly diagnosed endocrine disorders. Herein, we have summarized the management approaches of common endocrine disorders amid the ongoing pandemic.

Methods: We have performed an extensive literature search for articles in PubMed, EMBASE and Google Scholar databases till 25 May 2020, with the following keywords: "COVID-19", "diabetes mellitus", "thyroid disorders", "primary adrenal insufficiency", "Cushing's syndrome", "pituitary tumors", "vitamin D″", "osteoporosis", "primary hyperparathyroidism", "hypoparathyroidism", "management", "treatment" and "guidelines" with interposition of the Boolean operator "AND". Read More

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http://dx.doi.org/10.1016/j.dsx.2020.05.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271862PMC

Persistent hyperparathyroidism due to mediastinal parathyroid adenoma treated with selective arterial embolization with embosphere: first case in the literature.

Authors:
G Yuce N C Seyrek

Osteoporos Int 2020 Jun 5. Epub 2020 Jun 5.

Endocrinology and Metabolism Department, Ankara Yildirim Beyazit University, Ankara, Turkey.

Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia in the clinical setting and affects 0.3% of the population. Parathyroidectomy is the only definitive cure. Read More

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http://dx.doi.org/10.1007/s00198-020-05456-3DOI Listing

Local relapse of parathyroid adenomas: an uncommon cause of recurrent primary hyperparathyroidism.

Cir Esp 2020 May 31. Epub 2020 May 31.

Unidad de Cirugía Endocrina, Departamento de Cirugía General, Hospital del Mar, Barcelona, España.

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http://dx.doi.org/10.1016/j.ciresp.2020.04.019DOI Listing

KRAS mutations in brown tumor of the jaws in hyperparathyroidism.

J Oral Pathol Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Pathology, Institute of Biological Science, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

Background: Brown tumors are giant cell-rich lesions that result from abnormal bone metabolism in hyperparathyroidism, one of the most common endocrine disorders worldwide. Brown tumors occasionally affect the jaws and, despite well-known clinical and microscopic features, their molecular pathogenesis remains unclear. We investigated the presence of pathogenic activating mutations in TRPV4, FGFR1, and KRAS in a cohort of brown tumors since these have recently been reported in giant-cell lesions of the jaws and non-ossifying fibromas of the bones (FGFR1 and KRAS), which are histologic mimics of brown tumors. Read More

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http://dx.doi.org/10.1111/jop.13048DOI Listing

Antacid-induced acute hypercalcemia: An increasingly common and potentially dangerous occurrence.

SAGE Open Med Case Rep 2020 19;8:2050313X20921335. Epub 2020 May 19.

Department of Endocrinology, Richmond University Medical Center, Staten Island, NY, USA.

Hypercalcemia is frequently encountered in both hospital wards and the primary care setting; 90% of cases can be attributed to primary hyperparathyroidism and malignancy. However, a minority are caused by medications, of which calcium supplements have been an increasingly common etiology. We are presenting a case of hypercalcemia resulted after acute oral intake of a moderate amount of antacids (calcium tablets) and normalized after supplement withdrawal. Read More

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http://dx.doi.org/10.1177/2050313X20921335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238301PMC