12,247 results match your criteria Hyperparathyroidism Primary


A germline c.1546dupC MEN1 mutation in an MEN1 family: A case report.

Medicine (Baltimore) 2021 Jun;100(25):e26382

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chung-Ang University, College of Medicine, Seoul, Korea.

Rationale: Multiple endocrine neoplasia type 1 (MEN1) is a rare tumor syndrome with an autosomal dominant inheritance, and genetic testing for MEN1 gene is important for both affected individuals and their relatives. We present a 2-person family affected by a germline c.1546dupC MEN1 mutation, and one of them had a full-spectrum of MEN-related endocrine tumors. Read More

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Differences in Clinicopathological Characteristics of Papillary Thyroid Carcinoma between Symptomatic and Asymptomatic Patients with Primary Hyperparathyroidism.

Int J Endocrinol 2021 31;2021:9917694. Epub 2021 May 31.

Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China.

Background: Popularization of cervical ultrasound led to higher detection of papillary thyroid carcinoma (PTC) and primary hyperparathyroidism (PHPT), as well as increasing percentage of asymptomatic PHPT in China. Although the coexistence of PTC and PHPT has been reported, it is unknown whether the clinicopathological features of PTC differ between asymptomatic and symptomatic PHPT patients.

Methods: We retrospectively reviewed the medical records of 304 PHPT patients treated in our hospital between January 2009 and July 2020, including 217 females and 87 males with the average age of 53. Read More

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Intramuscular tumoral calcinosis near the arteriovenous fistula mimicking acute infection.

Sci Prog 2021 Apr-Jun;104(2):368504211018560

Department of Orthopedics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, P.R. China.

Tumoral calcinosis is a kind of tumorous calcified masses, which may progress in patients with chronic renal failure. Uremic tumoral calcinosis in the brachioradialis muscle presented like acute infection of the arteriovenous fistula has not been previously reported. A 49-year-old man came to our hospital with a 9-year history of hemodialysis and secondary hyperparathyroidism. Read More

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Do patients with atypical parathyroid adenoma need a close follow-up?

J Clin Endocrinol Metab 2021 Jun 22. Epub 2021 Jun 22.

Endocrine Unit, University Hospital of Pisa, Pisa, Italy.

Context: Atypical parathyroid adenomas (APAs) are neoplasms with uncertain malignant potential but lack unequivocal histological signs of malignancy.

Objective: To retrospectively evaluate the clinical and biochemical profiles of patients with APA, the outcome after parathyroidectomy (PTX), and the presence of CDC73 germline and somatic mutations.

Design: Monocentric study on consecutive patients undergoing PTX for primary hyperparathyroidism (PHPT) between June 2000 and December 2020. Read More

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European multicentre study on outcome of surgery for sporadic primary hyperparathyroidism.

Br J Surg 2021 Jun;108(6):675-683

Multidisciplinary Unit of Metabolic, Endocrine and Thyroid Surgery, Department of Surgery, Université de Lorraine, Centre Hospitalier Régional Universitaire Nancy, Vandoeuvre-lès Nancy, France.

Background: International multicentre outcome studies of surgery for primary hyperparathyroidism (pHPT), especially for rate of conversion to bilateral neck surgery and persistent hypercalcaemia, are scarce.

Methods: Eurocrine® is a European database for endocrine surgery. Data are entered according to predefined data fields. Read More

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GHRH secretion from a pancreatic neuroendocrine tumor causing gigantism in a patient with MEN1.

Endocrinol Diabetes Metab Case Rep 2021 Jun 1;2021. Epub 2021 Jun 1.

Department of Endocrinology, Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK.

Summary: A male patient with a germline mutation in MEN1 presented at the age of 18 with classical features of gigantism. Previously, he had undergone resection of an insulin-secreting pancreatic neuroendocrine tumour (pNET) at the age of 10 years and had subtotal parathyroidectomy due to primary hyperparathyroidism at the age of 15 years. He was found to have significantly elevated serum IGF-1, GH, GHRH and calcitonin levels. Read More

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Primary Hyperparathyroidism Masquerading as Acute Pancreatitis.

Horm Metab Res 2021 Jun 21;53(6):377-381. Epub 2021 Jun 21.

Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana, Punjab, India.

Acute pancreatitis as an initial manifestation of primary hyperparathyroidism (PHPT) is a rare occurrence and timely diagnosis of PHPT is crucial in preventing repeat attack of pancreatitis. The study aimed at evaluating the clinico-radiological profile of patients admitted with acute pancreatitis as the index presentation of PHPT and to determine the factors associated with development of severe pancreatitis. This series included retrospective analysis of medical records of 30 patients admitted with acute pancreatitis as initial manifestation of PHPT. Read More

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One in a billion: a patient with Marfan syndrome and familial hypocalciuric hypercalcaemia.

Endocrinol Diabetes Metab Case Rep 2021 Jun 1;2021. Epub 2021 Jun 1.

Department of Endocrinology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK.

Summary: Marfan syndrome is an autosomal dominant multisystem disorder that has an estimated incidence of 1 in 5000. It is caused by mutations in the FBN1 gene, which encodes the extracellular matrix protein type 1 fibrillin. Familial hypocalciuric hypercalcaemia (FHH), also inherited in an autosomal dominant pattern, is a rare benign disorder characterised by hypercalcaemia, hypocalciuria and relative hyperparathyroidism with normal or high plasma PTH levels, with an estimated incidence of between 1 in 10 000 to 1 in 100 000. Read More

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Isolated hypophosphataemia as an early marker of primary hyperparathyroidism.

Endocrinol Diabetes Metab Case Rep 2021 Jun 1;2021. Epub 2021 Jun 1.

Endocrinology and Diabetes, Mid-Yorkshire NHS Trust, Wakefield, England.

Summary: Primary hyperparathyroidism (PHPT) is a disease caused by overactive parathyroid glands with consequent hypercalcaemia. The main cause in 85-90% of the cases is the presence of a solitary parathyroid adenoma. The most common presentation is with asymptomatic hypercalcaemia diagnosed on routine biochemical testing. Read More

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[Normocalcemic with elevated post-operative parathormone in primary hyperpara-thyroidism: 9 case reports and literature review].

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Jun;53(3):573-579

Department of Endocrinology, China-Japanese Friendship Hospital, Beijing 100029, China.

Objective: To summarize and analyze the clinical characteristics of primary hyperpara-thyroidism (PHPT) with normocalcemic parathormone elevation (NPE) after surgical treatment, so as to improve the therapeutic ability and standardized post-operative follow-up of PHPT patients.

Methods: Nine patients who were diagnosed with PHPT in the Department of Endocrinology of China-Japan Friendship Hospital from August 2017 to November 2019 were selected as the subjects. They all developed NPE within 6 months after surgical treatment. Read More

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Focused parathyroidectomy without intraoperative parathyroid hormone measurement in primary hyperparathyroidism: Still a valid approach?

Surgery 2021 Jun 15. Epub 2021 Jun 15.

Endocrine Surgical Unit, University of Sydney, St Leonards, New South Wales, Australia; Sydney Medical School, Faculty of Medicine and Health, University of Sydney, New South Wales, Australia; Cancer Genetics Unit, Kolling Institute, Sydney, New South Wales, Australia.

Background: Concern regarding suboptimal cure rates has led to some endocrine surgery units abandoning focused parathyroidectomy for primary hyperparathyroidism in favor of open bilateral neck exploration or making intraoperative parathyroid hormone estimation mandatory in focused parathyroidectomy. This study explores whether focused parathyroidectomy for radiologically localized primary hyperparathyroidism without intraoperative parathyroid hormone is still a valid approach.

Methods: Retrospective review of a tertiary referral endocrine surgery unit database. Read More

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Giant versus regular parathyroid adenoma: A retrospective comparative study.

Ann Med Surg (Lond) 2021 Jun 29;66:102454. Epub 2021 May 29.

Department of Special Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan.

Background: A fraction of Parathyroid Adenoma (PTA) is considered giant if they weigh more than 3.5 g. There is no clear consensus whether this subgroup has a distinct clinical or biochemical presentation that could have implications on PTA localization and management. Read More

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Use and disparities in parathyroidectomy for symptomatic primary hyperparathyroidism in the Medicare population.

Surgery 2021 Jun 11. Epub 2021 Jun 11.

Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Background: Few studies assess use of parathyroidectomy among older adults with symptomatic primary hyperparathyroidism. Our objective was to determine national usage and disparities in parathyroidectomy for symptomatic primary hyperparathyroidism among insured older adults.

Methods: We identified older adult patients with symptomatic primary hyperparathyroidism using Medicare claims (2006-2017). Read More

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Association of parathyroidectomy with 5-year clinically significant kidney stone events in patients with primary hyperparathyroidism.

Endocr Pract 2021 Jun 11. Epub 2021 Jun 11.

Department of Surgery, Stanford University School of Medicine, Palo Alto, CA.

Objective: Patients with primary hyperparathyroidism (PHPT) are at increased risk of kidney stones. Guidelines recommend parathyroidectomy in PHPT patients with a history of stone disease. This study aimed to compare the 5-year incidence of clinically significant kidney stone events in patients with PHPT treated with parathyroidectomy vs. Read More

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Giant parathyroid adenoma diagnosed by brown tumour, a clinical manifestation of primary hyperparathyroidism: A case report.

J Pak Med Assoc 2021 Apr;71(4):1266-1269

Department of General Surgery, Sisli Hamidiye Etfal Medical Practice and Research Center, University of Health Sciences, Istanbul, Turkey.

Brown tumour (BT) is the pathological expression of osteitis fibrosa cystica which is caused due to primary and secondary hyperparathyroidism (HPT). It is a rare benign lesion of skeletal system that usually affects the facial bones, clavicles, ribs, pelvis and extremities. The purpose of this case report is to present the clinical, pathological and radiological findings of BT - rarely seen in adults - originating from the giant parathyroid adenoma and emerging as the first clinical sign of HPT. Read More

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Endocrine Dysfunction in Patients with Myotonic Dystrophy.

J Clin Endocrinol Metab 2021 Jun 14. Epub 2021 Jun 14.

Division of Endocrinology, Metabolism and Diabetes, University of Louisville, Louisville, KY.

Myotonic dystrophy is a dominantly inherited multisystem disorder that results from increased CTG repeats in the 3' region of the myotonic dystrophy protein kinase gene (DMPK). The mutant DMPK mRNA remains nuclear, and sequesters RNA-binding proteins including regulators of mRNA splicing. Myotonic dystrophy is characterized by a highly variable phenotype that includes muscle weakness and myotonia, and may affect the function of many Endocrine glands. Read More

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Hyperparathyroidism subsequent to radioactive iodine therapy for Graves' disease.

Head Neck 2021 Jun 14. Epub 2021 Jun 14.

Department of Otolaryngology-Head and Neck Surgery, Henry Ford Hospital, Detroit, Michigan, USA.

Background: The development of primary hyperparathyroidism (PHPT) after radioactive iodine (RAI) treatment for thyroid disease is poorly characterized. The current study is the largest reported cohort and assesses the disease characteristics of patients treated for PHPT with a history of RAI exposure.

Methods: A retrospective analysis comparing patients, with and without a history of RAI treatment, who underwent surgery for PHPT. Read More

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Synchronous incidental double parathyroid adenomas and papillary thyroid carcinoma: A case report with literature review.

Niger J Clin Pract 2021 Jun;24(6):954-963

Fellow, Breast and Endocrine Surgery, King Saud University, Riyadh, Saudi Arabia.

The association between parathyroid and thyroid diseases is not uncommon; however, the concurrent presence of parathyroid adenoma and thyroid cancer is rare. Awareness of this situation will enable clinicians to consider possible parathyroid pathology in patients with papillary thyroid cancer. The presence of parathyroid adenoma leading to primary hyperparathyroidism and the coexistence of thyroid papillary cancer is rare. Read More

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Cystic Parathyroid Adenomas: An Enigmatic Entity and Role of Tc-99 m Sestamibi Scintigraphy.

Endocr Pract 2021 Jun 13;27(6):614-620. Epub 2020 Dec 13.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India.

Objective: Functional cystic lesion of the parathyroid gland is a rare cause of primary hyperparathyroidism (PHPT). They have been postulated to arise from the hemorrhage and cystic degeneration in the parathyroid adenoma (PA). We intended to analyze their scintigraphic and histopathological findings since available literature is sparse. Read More

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18F-Choline PET/CT, MRI, and Software-Based Image Fusion Analysis in Patients With Primary Hyperparathyroidism.

Clin Nucl Med 2021 Jun 10. Epub 2021 Jun 10.

From the Institute of Nuclear Medicine and Endocrinology, Kepler University Hospital Linz GmbH Medical Faculty, Johannes Kepler University Linz Central Radiology Institute Department of General Surgery, Kepler University Hospital Linz GmbH, Linz Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria.

Purpose: The aim of this study was to evaluate the diagnostic performance of 18F-choline PET and MRI in patients with primary hyperparathyroidism. Furthermore, the additional value of software-based PET/MRI scan fusion was analyzed.

Patients And Methods: This retrospective study includes 42 patients (38 women) with an age between 32. Read More

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Primary Hyperaldosteronism and Renal Medullary Nephrocalcinosis: A Controversial Association.

Oman Med J 2021 May 31;36(3):e266. Epub 2021 May 31.

Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Kashmir, India.

Primary hyperaldosteronism (PA) is a common disease with a prevalence of 5-10% in unselected patients with hypertension. Medullary nephrocalcinosis is a radiological diagnosis and refers to diffuse calcification in the renal parenchyma. The three commonest causes of nephrocalcinosis are hyperparathyroidism, distal renal tubular acidosis, and medullary sponge kidney. Read More

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Generation of an induced pluripotent stem cell line HPCASRi002-A from a patient with neonatal severe primary hyperparathyroidism caused by a compound heterozygous mutation in the CASR gene.

Stem Cell Res 2021 Jun 4;54:102414. Epub 2021 Jun 4.

Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.

Neonatal severe primary hyperparathyroidism (NSHPT) is a rare autosomal recessive disorder of calcium homeostasis that manifests shortly after birth with hypercalcemia and bone disease. NSHPT, in most cases, is attributed to mutations in the calcium-sensing receptor (CASR) gene. We reprogrammed dermal fibroblasts derived from a patient with NSHPT carrying a compound heterozygous mutation in the CASR gene into induced pluripotent stem cells (iPSCs). Read More

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Serum iPTH range in a reference population: From an integrated approach to vitamin D prevalence impact evaluation.

Clin Chim Acta 2021 Jun 8;521:1-8. Epub 2021 Jun 8.

Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy; Unit of Laboratory Medicine, Tor Vergata University Hospital, Rome, Italy.

Background: The iPTH upper reference limit (URL) reported by our laboratory provider (Abbott Laboratories) at Tor Vergata University Hospital was evaluated by internal verification procedures as not representative of our population and resulting as underestimated. In this study, a new reference interval has been investigated and established by comparing a direct and an indirect method based on a statistical reduction from results stored in the laboratory database.

Methods: For reference interval calculation from the healthy population, we analyzed a cohort of 100 blood donors (84% males and 16% females) screened with no bone-related and malabsorption diseases. Read More

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Four-dimensional computed tomography protocol for preoperative evaluation of the parathyroid glands and its correlations with other imaging methods: a pictorial essay.

Radiol Bras 2021 May-Jun;54(3):193-197

Department of Imaging - A.C.Camargo Cancer Center, São Paulo, SP, Brazil.

Parathyroid adenoma is the most common cause of primary hyperparathyroidism. Advances in surgical techniques have made it possible to excise only the affected parathyroid gland in most cases. Imaging examinations play a fundamental role in the preoperative planning of parathyroidectomy. Read More

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Normocalcemic Primary Hyperparathyroidism: Need for a Standardized Clinical Approach.

Endocrinol Metab (Seoul) 2021 Jun 1. Epub 2021 Jun 1.

Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA.

Since normocalcemic primary hyperparathyroidism (NHPT) was first defined at the Third International Workshop on the Management of Asymptomatic Primary Hyperparathyroidism in 2008, many papers have been published describing its prevalence and possible complications. Guidelines for the management of this condition are still lacking, and making the diagnosis requires fulfillment of strict criteria. Recent studies have shown that intermittent oscillations of serum calcium just below and slightly above the normal limits are very frequent, therefore challenging the assumption that serum calcium must be consistently normal to make the diagnosis. Read More

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The Unforeseen Diagnosis: Hyperparathyroidism-Jaw Tumour Syndrome Case Report and Review of the Literature.

Case Rep Endocrinol 2021 20;2021:5551203. Epub 2021 May 20.

Milton Keynes University Hospital, Standing Way, Eaglestone, Milton Keynes MK6 5LD, UK.

Hypercalcaemia and its systemic sequelae are a relatively common finding amongst patients in the field of endocrinology. Primary hyperparathyroidism, a frequent cause of hypercalcaemia, is often seen among middle-aged female patients, typically resulting from an underlying single-gland adenoma. Although patients may present with symptoms (nephrolithiasis, musculoskeletal discomfort, dehydration, or mood disturbance, to name a few), hypercalcaemia is rather frequently identified incidentally. Read More

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A retrospective study of ultrasonography in the investigation of primary hyperparathyroidism:a new perspective for ultrasound echogenicity features of parathyroid nodules.

Endocr Pract 2021 Jun 5. Epub 2021 Jun 5.

Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. Electronic address:

Objective: To identify and understand parathyroid lesions of primary hyperparathyroidism (PHPT) patients more accurately under ultrasound (US).

Methods: This retrospective study involved 423 adult PHPT patients bearing a single parathyroid nodule with positive parathyroid ultrasonography between 2018 and 2019. The clinical characteristics of the study patients and histopathological sections were reviewed. Read More

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How should we define cure after parathyroidectomy for normocalcemic primary hyperparathyroidism? A retrospective cohort study.

Updates Surg 2021 Jun 7. Epub 2021 Jun 7.

Department of Surgery, Hospital Clínico San Carlos, C/ Profesor Martín Lagos SN, 28040, Madrid, Spain.

Cure after surgery for normocalcemic primary hyperparathyroidism (NHPT) is defined as parathyroid hormone (PTH) normalization. However, an increase of PTH is frequently observed in cured patients with hypercalcemic primary hyperparathyroidism (HHPT). Therefore, this criterion must be redefined. Read More

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Radiofrequency Ablation of Parathyroid Adenoma: A Novel Treatment Option for Primary Hyperparathyroidism.

AACE Clin Case Rep 2021 May-Jun;7(3):195-199. Epub 2021 Jan 13.

The Thyroid Clinic, Salt Lake City, Utah.

Objective: To present radiofrequency ablation (RFA) of parathyroid adenomas as a safe and effective management strategy for primary hyperparathyroidism in patients who are not eligible for surgery or those who do not want surgery.

Methods: The diagnosis of primary hyperparathyroidism was confirmed by laboratory investigations. A bone density scan showed osteoporosis, which was an indication for the surgical treatment of primary hyperparathyroidism. Read More

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January 2021

Renal Papillary Necrosis Associated With Normocalcemic Primary Hyperparathyroidism.

AACE Clin Case Rep 2021 Mar-Apr;7(2):113-116. Epub 2020 Dec 28.

Department of Endocrinology, Diabetes & Metabolism, Walter Reed National Military Medical Center, Bethesda, Maryland.

Objectives: Renal papillary necrosis (RPN) occurring in primary hyperparathyroidism (PHPT) has not been reported. We present a 50-year-old woman who manifested RPN associated with hypercalciuria and normocalcemic PHPT.

Methods: The diagnosis of RPN was based on imaging studies (ultrasound and computed tomography [CT] scan). Read More

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December 2020