33,214 results match your criteria Hyperparathyroidism

Primary familial brain calcification with mild phenotype due to a new PDGFB mutation.

Neurol Sci 2022 Jun 24. Epub 2022 Jun 24.

Department of Medical, Surgical and Neurological Sciences, Unit of Neurology and Neurometabolic Diseases, University of Siena, Viale Bracci 2, 53100, Siena, Italy.

Introduction: Primary familial brain calcification (PFBC) is a rare neurodegenerative disorder that presents cognitive and movement impairment. To diagnose PFBC, both brain calcium accumulations visible at computed tomography (CT) and autosomal dominant or recessive inherited genetic mutation(s) in one of the known genes have to be detected. We describe the case of a female patient aging 62, who presents marked calcifications at brain CT, not due to vitamin D deficiency. Read More

View Article and Full-Text PDF

Impact of etelcalcetide on fibroblast growth factor-23 and calciprotein particles in patients with secondary hyperparathyroidism undergoing hemodialysis.

Nephrology (Carlton) 2022 Jun 24. Epub 2022 Jun 24.

Department of Nephrology, Nagoya University Graduate School of Medicine, Aichi, Japan.

Background: Recently, we demonstrated the efficacy of etelcalcetide in the control of secondary hyperparathyroidism (SHPT). This post hoc analysis aimed to evaluate changes in fibroblast growth factor-23 (FGF23) and calciprotein particles (CPPs) after treatment with calcimimetics.

Methods: The DUET trial was a 12-week multicenter, open-label, parallel-group, randomized (1:1:1) study with patients treated with etelcalcetide plus active vitamin D (E+D group; n = 41), etelcalcetide plus oral calcium (E+Ca group; n = 41), or control (C group; n = 42) under maintenance hemodialysis. Read More

View Article and Full-Text PDF

Management of osteoporosis in patients with chronic kidney disease.

Osteoporos Int 2022 Jun 24. Epub 2022 Jun 24.

Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky, 800 Rose Street, Room MN-560, Lexington, KY, 40536-0298, USA.

Patients with CKD have a 4-fivefold higher rate of fractures. The incidence of fractures increases with deterioration of kidney function. The process of skeletal changes in CKD patients is characterized by compromised bone strength because of deterioration of bone quantity and/or quality. Read More

View Article and Full-Text PDF


Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):493-497

University of Sharjah, College of Medicine, Clinical Sciences Department, Sharjah, United Arab Emirates.

Context: Primary hyperparathyroidism related hypercalcemic crisis (PHHC) is a condition that may result in fetal course. So, the early diagnosis and treatment of these patients are important.

Objective: This study aimed to investigate the clinical features for hypercalcemic crisis (HC) by comparing the groups with and without primary hyperparathyroidism related calcemic crisis. Read More

View Article and Full-Text PDF

Inactivation of Osteoblast PKC Signaling Reduces Cortical Bone Mass and Density and Aggravates Renal Osteodystrophy in Mice with Chronic Kidney Disease on High Phosphate Diet.

Int J Mol Sci 2022 Jun 8;23(12). Epub 2022 Jun 8.

Center for Pediatric and Adolescent Medicine, Division of Pediatric Nephrology, University of Heidelberg, 69120 Heidelberg, Germany.

Chronic kidney disease (CKD) frequently leads to hyperphosphatemia and hyperparathyroidism, mineral bone disorder (CKD-MBD), ectopic calcifications and cardiovascular mortality. PTH activates the osteoanabolic Gα/PKA and the Gα/PKC pathways in osteoblasts, the specific impact of the latter in CKD-MBD is unknown. We generated osteoblast specific Gα knockout (KO) mice and established CKD-MBD by subtotal nephrectomy and dietary phosphate load. Read More

View Article and Full-Text PDF

USP37 Deubiquitinates CDC73 in HPT-JT Syndrome.

Int J Mol Sci 2022 Jun 7;23(12). Epub 2022 Jun 7.

Institute of Biomedical Industry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

The gene, a defect which causes hyperparathyroidism-jaw tumor (HPT-JT) syndrome, encodes CDC73/parafibromin. We aimed to investigate whether CDC73 would be a target for ubiquitin-proteasome degradation. We cloned full-length cDNAs encoding a family of 58 ubiquitin-specific deubiquitinating enzymes (DUBs), also known as ubiquitin-specific proteases (USPs). Read More

View Article and Full-Text PDF

Atypical parathyroid adenoma: Series of two consecutive cases from a tertiary care hospital in Qatar.

Int J Surg Case Rep 2022 Jun 10;96:107296. Epub 2022 Jun 10.

Department of General Surgery, Hamad General Hospital, Doha, Qatar. Electronic address:

Introduction: Atypical parathyroid adenomas (APA) are an uncommon cause of hypercalcemia and comprise a minority of parathyroid adenomas.

Presentation Of Cases: Case 1 - Egyptian male, 48 years old with history of type 2 diabetes mellitus, incidentally discovered increased serum of calcium level on routine investigation, was diagnosed as PHPT, US and MIBI scan showed large left inferior parathyroid adenoma, focused exploration and excision of the APA was undertaken, histopathology confirmed APA. Case 2 - Egyptian male, 60 years old, cardiac patient with history of diabetes, hypertension and multiple cardiac interventions, had nausea, vomiting, constipation abdominal pain, polyuria, polydipsia, and history of passing renal stones, hypercalcemia workup showed primary hyperparathyroidism (PHPT), MIBI was negative and SPECT scan suggested right inferior parathyroid adenoma, focused exploration and excision of the APA was undertaken, histopathology confirmed APA. Read More

View Article and Full-Text PDF

Multidetector-Row CT Findings in Dogs with Different Primary Parathyroid Gland Diseases.

Vet Sci 2022 Jun 6;9(6). Epub 2022 Jun 6.

Diagnostic and Interventional Radiology Division, San Marco Veterinary Clinic and Laboratory, 35030 Veggiano, Italy.

Primary hyperparathyroidism in dogs is a possibly life-threatening condition, characterized by the excess of parathyroid hormone (PTH) secretion, which leads to an increase in serum ionized calcium level. The utility of computed tomography (CT) in the detection and characterization of parathyroid diseases in dogs has not been assessed to date. Therefore, the aim of this study was to describe the use of multidetector-row CT (MDCT) for the diagnosis of parathyroid disease in dogs. Read More

View Article and Full-Text PDF

Giant cystic parathyroid adenoma: two case reports and a literature review.

J Int Med Res 2022 Jun;50(6):3000605221106419

Department of Endocrinology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, P.R. China.

An uncommon cause of primary hyperparathyroidism is a cystic parathyroid adenoma. This paper describes two patients with hypercalcemia and right knee disease. Their serum calcium concentration was high, phosphorus concentration was low, and parathyroid hormone (PTH) concentration was high. Read More

View Article and Full-Text PDF

A patient with hypercalcemia and hyperparathyroidism due to adenoma mimicking multiple myeloma.

Int J Lab Hematol 2022 Jun 23. Epub 2022 Jun 23.

Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Zhejiang, Hangzhou, China.

View Article and Full-Text PDF


Acta Clin Croat 2021 Dec;60(4):617-626

1Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 2University of Applied Health Sciences, Zagreb, Croatia; 3Department of Radiology and Nuclear Medicine, PET/CT Center, Medikol Polyclinic, Zagreb, Croatia; 4Department of Nuclear Medicine and Radiology, Martini Hospital, Groningen, The Netherlands; 5Department of Surgery, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 6School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

The bone health guidelines for breast cancer (BC) patients recommend bone mineral density (BMD) testing. Patients with low BMD and elevated serum calcium levels (SCLs) are further evaluated for primary hyperparathyroidism (PHPT). We aimed to determine the prevalence of PHPT in treated BC patients with low BMD and analyze the association of SCLs with histopathologic tumor features and cancer treatment. Read More

View Article and Full-Text PDF
December 2021

A multi-institutional study evaluating and describing atypical parathyroid tumors discovered after parathyroidectomy.

Laryngoscope Investig Otolaryngol 2022 Jun 19;7(3):901-905. Epub 2022 May 19.

Department of Otolaryngology - Head and Neck Surgery University of Cincinnati College of Medicine Cincinnati Ohio USA.

Objective: To describe common intraoperative and pathologic findings of atypical parathyroid tumors (APTs) and evaluate clinical outcomes in patients undergoing parathyroidectomy.

Methods: In this multi-institutional retrospective case series, data were collected from patients who underwent parathyroidectomy from 2000 to 2018 from three tertiary care institutions. APTs were defined according to the AJCC eighth edition guidelines and retrospective chart review was performed to evaluate the incidence of recurrent laryngeal nerve injury, recurrence of disease, and disease-specific mortality. Read More

View Article and Full-Text PDF

Ectopic Pleural Parathyroid Adenoma Causing Recurrent Primary Hyperparathyroidism.

Cureus 2022 May 18;14(5):e25101. Epub 2022 May 18.

Endocrinology, Diabetes and Metabolism, Minneapolis Veterans Affairs Health Care System, Minneapolis, USA.

Ectopic parathyroid glands can cause primary hyperparathyroidism (PHPT) in up to 16% of cases. These can lead to recurrent/persistent PHPT, and multiple cases have been described in the literature. We present a case of a pleural parathyroid adenoma leading to persistent PHPT. Read More

View Article and Full-Text PDF

A case of familial hypocalciuric hypercalcemia type 1 due to CASR p.Pro55Leu mutation.

BMC Endocr Disord 2022 Jun 22;22(1):164. Epub 2022 Jun 22.

Department of Diabetes, Endocrinology and Metabolism/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.

Background: Familial hypocalciuric hypercalcemia (FHH) is a rare autosomal dominant disease, which requires differential diagnosis from relatively common primary hyperparathyroidism (PHPT) in order to avoid unnecessary surgery.

Case Presentation: A 16-year-old female had been followed by the department of psychosomatic medicine at our institution. Throughout the follow-up period, her plasma calcium levels were high, plasma Pi levels were relatively low, and plasma intact PTH was relatively high. Read More

View Article and Full-Text PDF

Misdiagnosed giant parathyroid cyst: differential diagnosis of a neck mass of the central region.

BMJ Case Rep 2022 Jun 22;15(6). Epub 2022 Jun 22.

Division of Endocrine Surgery, Department of Gastroenterologic, Endocrine-Metabolic and Nephro-Urologic Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Parathyroid cysts (PCs) are rare benign lesions representing between the 0.08% and the 0.34% of the neck masses going on surgery. Read More

View Article and Full-Text PDF

The rate, cost and outcomes of parathyroidectomy in the united states dialysis population from 2016-2018.

BMC Nephrol 2022 Jun 21;23(1):220. Epub 2022 Jun 21.

Division of Nephrology and Hypertension, Georgetown University, Washington, DC, USA.

Background: In end-stage kidney disease, patients may undergo parathyroidectomy if secondary hyperparathyroidism cannot be managed medically. This study was designed to estimate the parathyroidectomy rate in the United States (US) and to quantify changes in costs and other outcomes after parathyroidectomy.

Methods: This was a retrospective observational cohort study using US Renal Data System data for 2015-2018. Read More

View Article and Full-Text PDF

Editorial: Narrow the gap, build a bridge: an inspirational approach to chronic kidney disease-mineral and bone disorder.

Curr Opin Nephrol Hypertens 2022 Jul;31(4):303-305

Division of Nephrology and Hypertension, Department of Medicine and Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

View Article and Full-Text PDF

Calciphylaxis and Ulcerative Lesions of Bilateral Nipple-Areolar Complex Due to Alcoholic Liver Disease.

Indian J Radiol Imaging 2022 Mar 1;32(1):142-144. Epub 2022 May 1.

Department of Gastroenterology and Hepatology, Grande International Hospital, Dhapasi, Kathmandu, Nepal.

When faced with eczematous lesions involving the nipple-areolar complex (NAC), Paget's disease is assumed to be the diagnosis, anything else being considered a "Zebra" necessitating its exclusion on pathology. A middle-aged lady presented with synchronous asymmetrical ulceration of bilateral NAC with pleomorphic calcifications on mammography and simultaneous extensive vascular calcification in bilateral breasts that suggested systemic cause. Calciphylaxis is a rare diagnosis occurring usually due to underlying end-stage renal disease or hyperparathyroidism. Read More

View Article and Full-Text PDF

Using QCT to evaluate bone mineral and abdominal adipose changes in patients with primary hyperparathyroidism and comparing it to DXA for bone status assessment: a retrospective case-control study.

Ann Transl Med 2022 May;10(10):606

Department of Radiology, Ruijin Hospital Luwan Branch, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Background: Patients with primary hyperparathyroidism (PHPT) show changes in bone metabolism and adipose tissue, but the results are inconsistent. Quantitative computed tomography (QCT) was reported useful for detecting bone mineral and adipose tissue change, but information on the role of QCT in PHPT is limited. We aimed to explore the changes of lumbar bone mineral density (BMD) and abdominal adipose tissue in patients with PHPT using QCT based on existed CT images, and to assess the consistency between QCT and dual-energy X-ray absorptiometry (DXA) in assessing bone status. Read More

View Article and Full-Text PDF

Calciphylaxis: A Long Road to Cure with a Multidisciplinary and Multimodal Approach.

Case Rep Nephrol 2022 8;2022:3818980. Epub 2022 Jun 8.

Department of Nephrology, National and Kapodistrian University of Athens, Attikon Hospital, Athens, Greece.

Calciphylaxis is a rare yet potentially fatal condition, resulting from ectopic calcification of the small arterioles of the dermis with resulting necrotic lesions infection, sepsis, and death. In hemodialysis patients, its prevalence ranges between 1 and 4%, while mortality amounts to 30-80%. We present in here a 45-year-old female on chronic dialysis with morbid obesity, who was admitted for painful nodules in the lower abdomen and necrotic lesions at the lower extremities. Read More

View Article and Full-Text PDF

Parathyroid Crisis as Presentation of Atypical Parathyroid Adenoma: Two Diagnostically Challenging Cases.

J Bone Metab 2022 May 31;29(2):133-140. Epub 2022 May 31.

Department of Endocrinology, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México, Mexico.

Atypical parathyroid adenoma (APA) is a rare cause of primary hyperparathyroidism (PHPT) and represents a diagnostic challenge since it is an intermediate form of parathyroid neoplasm of uncertain malignant potential with atypical histological features that require differential diagnosis of parathyroid carcinoma (PC). We present 2 cases of parathyroid crisis as a presentation of APA. The first case was that of a 56-year-old man with parathyroid crisis, constitutional syndrome, and anemia, with evidence of APA after en bloc resection, evolving with hungry bone syndrome after surgery and curation criteria at 6 months after parathyroidectomy (PTX). Read More

View Article and Full-Text PDF

Efficacy and safety of radiofrequency ablation versus parathyroidectomy for secondary hyperparathyroidism in dialysis patients: a single-center retrospective study.

Sci Rep 2022 Jun 18;12(1):10289. Epub 2022 Jun 18.

Urology and Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.

We compared the efficacy and safety of ultrasound (US)-guided radiofrequency ablation (RFA) and parathyroidectomy (PTX) for the treatment of secondary hyperparathyroidism (SHPT). In this single-center retrospective study, we divided patients into PTX (n = 53) and RFA (n = 47) groups. The primary outcome was the proportion of patients who achieved the target intact parathyroid hormone (iPTH) concentration range (≤ 300 pg/mL). Read More

View Article and Full-Text PDF

Are patients with limited English proficiency less likely to undergo parathyroidectomy for primary hyperparathyoidism?

Am J Surg 2022 Jun 8. Epub 2022 Jun 8.

Harvard Medical School, Boston, MA, USA; Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address:

Background: Despite meeting operative indications for primary hyperparathyroidism (PHPT), many patients never undergo parathyroidectomy. We hypothesized that patients with limited English proficiency (LEP) would be less likely to undergo parathyroidectomy than English-proficient (EP) patients.

Study Design: We retrospectively analyzed patients with PHPT from an institution-wide registry who met operative criteria between 2010 and 2018. Read More

View Article and Full-Text PDF

The Evaluation of Correlation Between Serum PTH and Dentoskeletal Changes in Panoramic Imaging of Hemodialysis Patients.

Iran J Kidney Dis 2022 May;16(3):203-208

Department of Maxillofacial Radiology, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran.

Introduction: This study aimed to investigate the relationship between serum levels of PTH and dental and bone changes in the panoramic view of hemodialysis patients.

Methods: Out of 236 patients with end-stage kidney disease (ESKD) who were hospitalized in two hemodialysis centers, 68 ones were selected and concerning their PTH serum levels, they were assigned to case group (PTH > 300 pg/mL) and control group (150 < PTH < 300 pg/mL). Patients in both groups had undergone dialysis for at least 6 months. Read More

View Article and Full-Text PDF

Case Report: Primary Hyperparathyroidism due to Posterior Mediastinal Parathyroid Adenoma With One-Year Follow-Up.

Front Surg 2022 31;9:893259. Epub 2022 May 31.

Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, China.

Ectopic parathyroid adenoma, though rare, is one of the causes of persistent hyperparathyroidism and recurrence of hyperparathyroidism. Ectopic parathyroid glands can be seen in thymus, thyroid, and mediastinum. However, ectopic parathyroid adenoma occurred in the posterior superior mediastinum is extremely rare. Read More

View Article and Full-Text PDF

Elevated parathyroid hormone one year after kidney transplantation is an independent risk factor for graft loss even without hypercalcemia.

BMC Nephrol 2022 Jun 17;23(1):212. Epub 2022 Jun 17.

Department of Transplant and Endocrine Surgery, Japanese Red Cross Nagoya Daini Hospital, 2-9 Myoken-cho, Showa-ku, Nagoya, Aichi, 4668650, Japan.

Background: Hypercalcemic hyperparathyroidism has been associated with poor outcomes after kidney transplantation (KTx). However, the clinical implications of normocalcemic hyperparathyroidism after KTx are unclear. This retrospective cohort study attempted to identify these implications. Read More

View Article and Full-Text PDF

Predicting ultrasound-guided thermal ablation benefit in primary hyperparathyroidism.

Eur Radiol 2022 Jun 16. Epub 2022 Jun 16.

Department of Interventional Ultrasound, The Fifth Medical Center, Chinese PLA General Hospital, NO. 28 Fuxing Road, Beijing, 100853, China.

Objectives: Ultrasound (US)-guided thermal ablation for primary hyperparathyroidism (PHPT) is a relatively novel minimally invasive treatment. The recurrence rate after ablation is between 10 and 15%. The characteristics of patients who can benefit from thermal ablation therapy are not clear yet. Read More

View Article and Full-Text PDF

Hypotension associated with high cardiac output and low systemic vascular resistance in a patient with hyperparathyroidism and hypercalcemia.

J Anaesthesiol Clin Pharmacol 2022 Jan-Mar;38(1):150-152. Epub 2022 Apr 25.

Department of Anesthesiology and Critical Care, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

View Article and Full-Text PDF

Accuracy of Parathyroid Adenoma Localization by Preoperative Ultrasound and Sestamibi in 1089 Patients with Primary Hyperparathyroidism.

World J Surg 2022 Jun 15. Epub 2022 Jun 15.

Department of Endocrine Surgery, Schön Klinik Hamburg-Eilbek, Dehnhaide 120, 22081, Hamburg, Germany.

Background: Primary hyperparathyroidism (pHPT) is well treatable surgically. Sonography (US) and sestamibi scintigraphy (MIBI) are used routinely, but it is unclear how valuable they are in determining Parathyroid glands' different locations. This study aimed to evaluate the prognostic value of US and MIBI in relation to the different localization of parathyroid adenomas in one of the largest study populations analyzed to date. Read More

View Article and Full-Text PDF

Prevalence and associated factors of secondary hyperparathyroidism after Roux-en-Y gastric bypass: A meta-analysis.

Obes Rev 2022 Jun 15:e13488. Epub 2022 Jun 15.

Department of Gastrointestinal Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.

This study aimed to investigate the prevalence and factors associated with secondary hyperparathyroidism (SHPT) after Roux-en-Y gastric bypass (RYGB). We searched PubMed, EMBASE, and CENTRAL for relevant studies using search terms gastric bypass, RYGB and hyperparathyroidism. Thirty-four cohort studies with 4331 patients were incorporated into the final meta-analysis. Read More

View Article and Full-Text PDF