31,324 results match your criteria Hyperparathyroidism


Severe Hypercalcemia in an Adolescent with New-Onset Diabetes Mellitus and Diabetic Ketoacidosis.

Cureus 2020 Jun 4;12(6):e8435. Epub 2020 Jun 4.

Pediatric Endocrinology, Nemours Children's Hospital, Orlando, USA.

Severe hypercalcemia in diabetic ketoacidosis (DKA) among children is rare and can be life-threatening. Its exact etiology is not clear and several mechanisms related to dehydration and metabolic acidosis have been proposed. Rigorous hydration with the correct fluid choice usually corrects the hypercalcemia in those without other underlying causes of hypercalcemia such as hyperparathyroidism. Read More

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http://dx.doi.org/10.7759/cureus.8435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336636PMC

A Case of Hyperparathyroidism Which Developed After Resection of a Fibroblast Growth Factor 23-producing Tumor.

Intern Med 2020 Jul 7. Epub 2020 Jul 7.

First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

A 53-year-old woman presented with bone pain and was diagnosed with osteomalacia because of hypophosphatemia, hyperphosphatasemia, bone pain, and radiographic findings. Because her intact-fibroblast growth factor 23 (FGF23) levels were high and contrast-enhanced computed tomography revealed a mass in the anterior ethmoid sinus, FGF23-related osteomalacia was diagnosed. The tumor was resected, but she developed hypercalcemia and elevated blood parathyroid hormone (PTH) levels. Read More

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http://dx.doi.org/10.2169/internalmedicine.4412-19DOI Listing

Nutritional Status of Obese Taiwanese Before Bariatric-Metabolic Surgery and Their Serum 25-Hydroxyvitamin D Concentrations for Maximal Suppression of Parathyroid Hormone.

Obes Surg 2020 Jul 8. Epub 2020 Jul 8.

Department of Nutrition, China Medical University, 91 Hsueh-Shih Road, Taichung, 404, Taiwan.

Background: This is the first report from Taiwan using laboratory tests to assess nutritional status of patients with obesity before bariatric-metabolic surgery. Moreover, the 25(OH)D threshold for maximal suppression of parathyroid hormone (PTH) was evaluated to offer a reference value for preoperative nutritional care.

Methods: Inclusion criteria were Taiwanese, 18-65 years old, and with BMI ≥ 27. Read More

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http://dx.doi.org/10.1007/s11695-020-04759-yDOI Listing

Functional Analysis of Calcium-Sensing Receptor Variants Identified in Families Provisionally Diagnosed with Familial Hypocalciuric Hypercalcaemia.

Calcif Tissue Int 2020 Jul 8. Epub 2020 Jul 8.

Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Block C, Level 1, Hospital Avenue, Nedlands, WA, Australia.

Identification of variants in the calcium-sensing receptor (CASR) gene is an important means of distinguishing between familial hypocalciuric hypercalcaemia (FHH) and primary hyperparathyroidism. However, identification and bioinformatics analysis of genetic variants alone is now considered insufficient as definitive proof; additional functional assessment is required to diagnose FHH with certainty. We identified two novel variants, D433Y and C739Y, and one previously reported variant G509R in the CASR of four kindreds provisionally diagnosed with FHH and aimed to functionally characterise these variants to confirm the diagnosis. Read More

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http://dx.doi.org/10.1007/s00223-020-00715-1DOI Listing

Hypocalcemia after ultrasound-guided microwave ablation and total parathyroidectomy for secondary hyperparathyroidism: a retrospective study.

Int J Hyperthermia 2020 ;37(1):819-825

Department of Interventional Ultrasound, China-Japan Friendship Hospital, Beijing, China.

Objective: To compare the postoperative hypocalcemia between ultrasound-guided microwave ablation (MWA) and total parathyroidectomy (TPTX) for secondary hyperparathyroidism (SHPT).

Methods: The retrospective study reviewed 286 SHPT patients (171 received MWA and 115 underwent TPTX) between March 2018 and May 2019. Propensity-score matching was used to assemble a cohort of patients with similar baseline characteristics. Read More

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http://dx.doi.org/10.1080/02656736.2020.1785557DOI Listing
January 2020

Hypercalcemia caused by comorbid parathyroid adenoma and pulmonary tuberculosis.

CEN Case Rep 2020 Jul 6. Epub 2020 Jul 6.

Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan.

Hypercalcemia is usually secondary to one etiology, although two coexisting etiologies can rarely cause hypercalcemia. Here, we report a 47-year-old woman with hypercalcemia caused by comorbid parathyroid adenoma and pulmonary tuberculosis. Primary hyperparathyroidism is the most common cause of hypercalcemia. Read More

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http://dx.doi.org/10.1007/s13730-020-00509-2DOI Listing

How to manage osteoporosis before the age of 50.

Maturitas 2020 Aug 18;138:14-25. Epub 2020 May 18.

Department of Medicine, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.

This narrative review discusses several aspects of the management of osteoporosis in patients under 50 years of age. Peak bone mass is genetically determined but can also be affected by lifestyle factors. Puberty constitutes a vulnerable period. Read More

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http://dx.doi.org/10.1016/j.maturitas.2020.05.004DOI Listing
August 2020
2.942 Impact Factor

Persistent secondary hyperparathyroidism caused by parathyromatosis and supernumerary parathyroid glands in a patient on haemodialysis.

BMC Nephrol 2020 Jul 6;21(1):257. Epub 2020 Jul 6.

The Department of Nuclear Medicine, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, People's Republic of China.

Background: Secondary hyperparathyroidism (SHPT) is a common high-risk factor for mortality in end-stage renal disease, and parathyromatosis and supernumerary parathyroid glands are very rare causes of persistent SHPT. Preoperative diagnosis and removal of all hyperplastic parathyroid glands are challenging. We report a rare case of persistent SHPT due to parathyromatosis and supernumerary parathyroid glands and successful management by multiple imaging modalities. Read More

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http://dx.doi.org/10.1186/s12882-020-01917-3DOI Listing

Can patients find an Endocrine Surgeon? How hospital websites hide the expertise of these medical professionals.

Am J Surg 2020 Jun 19. Epub 2020 Jun 19.

Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address:

Background: With information on healthcare providers available on the internet, patient self-referral has become popular. This study serves to evaluate the ease with which patients can locate an Endocrine Surgeon using hospital websites.

Methods: Websites of the 16 top academic hospitals from The US News and World Report's Hospital Rankings for 2018-2019 were accessed. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.06.016DOI Listing

Cinacalcet and primary hyperparathyroidism: systematic review and meta regression.

Endocr Connect 2020 Jul 1. Epub 2020 Jul 1.

C Khoo, Medicine, NUS Yong Loo Lin School of Medicine, Singapore, 117597, Singapore.

Purpose: Primary hyperparathyroidism (PHPT) is common condition, affecting people of all ages and is mainly treated with parathyroidectomy. Cinacalcet has been widely used in secondary or tertiary hyperparathyroidism, but the use of cinacalcet in PHPT is less clear.

Methods: Searches were conducted in Medline and Embase for cinacalcet use in PHPT from induction to 10th April 2020. Read More

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http://dx.doi.org/10.1530/EC-20-0221DOI Listing

Effects of denosumab as compared with parathyroidectomy regarding calcium, renal, and bone involvement in osteoporotic patients with primary hyperparathyroidism.

Endocrine 2020 Jul 3. Epub 2020 Jul 3.

Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.

Purpose: To evaluate the effects of denosumab (Dmb) on calcium, renal, and bone involvement in osteoporotic patients with primary hyperparathyroidism (PHPT) and compare with those who underwent a parathyroidectomy (PTX) procedure.

Methods: This retrospective, longitudinal study included patients treated with Dmb (60 mg) once every 6 months (n = 19) and those who successfully underwent a PTX procedure (n = 19) corrected calcium (cCa), eGFR, bone mineral density (BMD) in the lumbar spine (LS), total hip (TH), and femoral neck (FN) and LS-trabecular bone score (TBS) changes at 1 year after beginning Dmb or undergoing PTX were measured.

Results: Dmb group had older age, and showed milder disease activity and lower eGFR as compared with PTX group. Read More

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http://dx.doi.org/10.1007/s12020-020-02401-6DOI Listing

Low bone mineral density due to secondary hyperparathyroidism in the mouse model of Fabry disease.

FASEB Bioadv 2020 Jun 10;2(6):365-381. Epub 2020 Jun 10.

Department of Matrix Medicine Faculty of Medicine Oita University Yufu Oita Japan.

Low bone mineral density (BMD)-diagnosed as osteoporosis or osteopenia-has been reported as a new characteristic feature of Fabry disease; however, the mechanism underlying the development of low BMD is unknown. We previously revealed that a mouse model of Fabry disease [] exhibits impaired functioning of medullary thick ascending limb (mTAL), leading to insufficient Ca reabsorption and hypercalciuria. Here, we investigated bone metabolism in mice without marked glomerular or proximal tubular damage. Read More

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http://dx.doi.org/10.1096/fba.2019-00080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325589PMC

A Combination of Hemodialysis with Hemoperfusion Helped to Reduce the Cardiovascular-Related Mortality Rate after a 3-Year Follow-Up: A Pilot Study in Vietnam.

Blood Purif 2020 Jul 2:1-8. Epub 2020 Jul 2.

Vietnam Military Medical University, Ha Noi, Vietnam,

Aims: Moderate to severe hyperparathyroidism (parathyroid hormone [PTH] concentrations ≥600 pg/mL) may increase the risk of cardiovascular problems and bone disease. We assume that a combination of hemodialysis with hemoperfusion may reduce the cardiovascular-related mortality rate in maintenance hemodialysis.

Subjects And Methods: From 625 maintenance hemodialysis patients, 93 people met with our inclusion criteria. Read More

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http://dx.doi.org/10.1159/000507912DOI Listing

Case Report: Familial Hypocalciuric Hypercalcaemia and Hashimoto's Thyroiditis.

Front Surg 2020 16;7:30. Epub 2020 Jun 16.

Department of Transplant and Endocrine Surgery, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.

Hypercalcaemia can be caused by many disorders. Primary hyperparathyroidism is the leading cause with parathyroidectomy being the definitive management. Familial hypocalciuric hypercalcaemia is a rarer cause in which resection of the parathyroid tissue does not result in normalized serum calcium. Read More

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http://dx.doi.org/10.3389/fsurg.2020.00030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308482PMC

MEN Type I (Wermer Syndrome).

J Assoc Physicians India 2020 May;68(5):51-52

PG Student, RNT Medical College, Udaipur, Rajasthan.

MEN I inherited as an autosomal dominant disorder leads to hyperplastic/ neoplastic changes in parathyroid, pituitary and endocrine pancreas along with other characteristic tumours. Hyperparathyroidism is the most common manifestation of MEN I. Our case was a female patient aged 42 years who was diagnosed with parathyroid adenoma, coincident with pancreatic neoplasm and adrenal adenoma. Read More

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Comprehensive treatment of rare multiple endocrine neoplasia type 1: A case report.

World J Clin Cases 2020 Jun;8(12):2647-2654

Department of Hepatobiliary, Hebei General Hospital, Shijiazhuang 050017, Hebei Province, China.

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary disorder caused by mutations of the gene. It is characterized by hyperparathyroidism and involves the pancreas, anterior pituitary, duodenum, and adrenal gland. Here, we report a 40-year-old male patient with MEN1 who first manifested as thymic carcinoid, then primary hyperparathyroidism and prolactinoma, and a decade later pancreatic neuroendocrine tumor. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i12.2647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322426PMC

Evaluation of Serum Level of FGF23 and 1,25(OH)D in Primary Hyperparathyroidism Patients Before and After Parathyroidectomy.

Int J Gen Med 2020 11;13:289-295. Epub 2020 Jun 11.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: Parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) play critical roles in phosphate homeostasis. To the best of our knowledge, there are limited data on the impact of FGF23 and PTH on serum calcium, 1,25(OH)D, and phosphate in patients with primary hyperparathyroidism (PHPT). We examined these parameters and their correlations in PHPT patients before and after parathyroidectomy (PTX). Read More

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http://dx.doi.org/10.2147/IJGM.S253246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295333PMC

Benefit of diverse surgical approach on short-term outcomes of MEN1-related hyperparathyroidism.

Sci Rep 2020 Jun 30;10(1):10634. Epub 2020 Jun 30.

Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Republic of Korea.

Surgical excision is the preferred treatment for multiple endocrine neoplasia type 1 (MEN1)-related primary hyperparathyroidism (PHPT), although controversy regarding the surgical strategy exists. We retrospectively investigated the short-term outcomes of PHPT by various surgical extents. Thirty-three patients who underwent parathyroidectomy due to MEN1-related PHPT at Yonsei Severance Hospital between 2005 and 2018 were included (age [mean ± SD], 43. Read More

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http://dx.doi.org/10.1038/s41598-020-67424-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326992PMC

F-Fluorocholine PET and Multiphase CT Integrated in Dual Modality PET/4D-CT for Preoperative Evaluation of Primary Hyperparathyroidism.

J Clin Med 2020 Jun 26;9(6). Epub 2020 Jun 26.

Nuclear Medicine and Molecular Imaging, ICANS-University Hospitals of Strasbourg, 67033 Strasbourg, France.

The present retrospective study evaluates the diagnostic value of integrated F-Fluorocholine positron emission tomography/four-dimensional contrast-enhanced computed tomography (F-FCH PET/4D-CT) as second-line imaging in preoperative work-up of primary hyperparathyroidism (pHPT), and compares F-FCH PET with 4D-CT. Patients with pHPT and negative/discordant first-line imaging addressed for integrated F-FCH PET/4D-CT were retrospectively selected. Sensitivity and detection rate (DR%) of F-FCH PET/CT, 4D-CT, and PET/4D-CT were calculated according to the per patient and per lesion analyses, and afterwards compared. Read More

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http://dx.doi.org/10.3390/jcm9062005DOI Listing

Improvement in bone involvement of secondary hyperparathyroidism post-parathyroidectomy.

Joint Bone Spine 2020 Jun 26. Epub 2020 Jun 26.

Service de rhumatologue, CHU de Toulouse, hôpital Pierre-Paul-Riquet, 1, place du Dr-Baylac, 31059, Toulouse cedex, France.

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http://dx.doi.org/10.1016/j.jbspin.2020.06.006DOI Listing

Inhibition of osteoclast differentiation by 1.25-D and the calcimimetic KP2326 reveals 1.25-D resistance in advanced CKD.

J Bone Miner Res 2020 Jun 29. Epub 2020 Jun 29.

INSERM, UMR 1033, Faculté de Médecine Lyon Est, Université Claude Bernard Lyon1, Lyon, France.

Active vitamin D analogs and calcimimetics are the main therapies used for treating secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD). Peripheral blood mononuclear cells (PBMCs) of 19 pediatric patients with CKD1-5D and 6 healthy donors (HD) were differentiated into mature osteoclasts with RANK-L and M-CSF. The effects of single or combined treatment with active vitamin D (1. Read More

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http://dx.doi.org/10.1002/jbmr.4122DOI Listing

Giant parathyroid adenoma: a rare cause of primary hyperparathyroidism mimicking a carcinoma.

Endokrynol Pol 2020 Jun 29. Epub 2020 Jun 29.

Surgical Oncology, Garibaldi-Nesima Hospital, Via Palermo n° 636, 95122 Catania, Italy.

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http://dx.doi.org/10.5603/EP.a2020.0035DOI Listing

FGF23 and primary hyperparathyroidism: is there a link?

Endokrynol Pol 2020 Jun 29. Epub 2020 Jun 29.

Grigore. T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.

Introduction: Data regarding the role of FGF23 in primary hyperparathyroidism (PHPT) are scarce and discordant. Our study aimed at evaluating the prognostic impact of FGF23 upon the clinical and biochemical evolution of PHPT.

Materials And Methods: 42 patients with ages between 30 - 80 years diagnosed with PHPT caused by a sporadic, solitary parathyroid adenoma and referred to surgery (minimally invasive parathyroidectomy) were prospectively included in the study. Read More

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http://dx.doi.org/10.5603/EP.a2020.0030DOI Listing

Revisiting a Case of Parathyroid Adenoma With Bilateral Staghorn Calculus.

Cureus 2020 May 23;12(5):e8251. Epub 2020 May 23.

General Medicine, Government Medical College and Hospital, Chandigarh, IND.

Parathyroid gland adenoma is responsible for approximately 80%-85% cases of primary hyperparathyroidism. Although not much is diagnostic on clinical examination, the blood investigations of the patients reveal raised serum calcium and serum parathyroid hormone levels. We present a case of chronic kidney disease with bilateral staghorn calculi and a right parathyroid adenoma localized on ultrasonography. Read More

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http://dx.doi.org/10.7759/cureus.8251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308822PMC

Recurrent hyperparathyroidism due to parathyroid and pulmonary tumors showing features of parathyroid adenoma.

Radiol Case Rep 2020 Aug 18;15(8):1289-1294. Epub 2020 Jun 18.

Department of Pathology, St. Marianna University School of Medicine University Hosital, Kawasaki, Kanagawa, Japan.

We report on a case of recurrent primary hyperparathyroidism possibly caused by parathyroid adenocarcinoma metastasizing to the lung. A 46-year-old woman with a history of parathyroid adenoma, which was extirpated 8 years ago, presented with symptoms of primary hyperparathyroidism, and was found to have a parathyroid and a lung nodule in radiographic assessments. Resections of the tumors in the parathyroid gland as well as the lung were required to improve her condition, and in pathology, both tumors demonstrated benign features consistent with adenoma. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306540PMC

Spironolactone reduces biochemical markers of bone turnover in postmenopausal women with primary aldosteronism.

Endocrine 2020 Jun 27. Epub 2020 Jun 27.

Medizinische Klinik und Poliklinik IV, Klinikum der Universität, LMU München, Ziemssenstraße 1, 80336, Munich, Germany.

Context: Primary aldosteronism (PA) is the most frequent form of endocrine hypertension. Besides its deleterious impact on cardiovascular target organ damage, PA is considered to cause osteoporosis.

Patients And Methods: We assessed bone turnover in a subset of 36 postmenopausal women with PA. Read More

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http://dx.doi.org/10.1007/s12020-020-02348-8DOI Listing

Surgical Outcomes of Parathyroidectomy for Secondary Hyperparathyroidism resistant to calcimimetic treatment: a Retrospective Single-center Cohort Study.

Ther Apher Dial 2020 Jun 27. Epub 2020 Jun 27.

Department of Pathology, Aichi Medical University School of Medicine, Nagakute, Japan.

To evaluate the surgical outcomes of parathyroidectomy (PTx) for secondary hyperparathyroidism (SHPT) resistant to calcimimetic treatment, we retrospectively studied 187 patients with SHPT who had no history of calcimimetic treatment (NCMT group) and 186 patients with SHPT who were resistant to calcimimetic treatment (RCMT group). Success rate and operative time of PTx were compared among the two groups. Operative time was significantly longer in the RCMT group than in the NCMT group (180 vs. Read More

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http://dx.doi.org/10.1111/1744-9987.13553DOI Listing

Genotype of CDC73 germline mutation determines risk of parathyroid cancer.

Endocr Relat Cancer 2020 Jun 1. Epub 2020 Jun 1.

W Simonds, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases Metabolic Diseases Branch, Bethesda, 20892-1752, United States.

Mutation of the CDC73 gene, which encodes parafibromin, has been linked with parathyroid cancer. However, no correlation between genotypes of germline CDC73 mutations and the risk of parathyroid cancer has been known. In this study, subjects with germline CDC73 mutations were identified from the participants of two clinical protocols at National Institutes of Health (Discovery Cohort) and from the literature (Validation Cohort). Read More

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http://dx.doi.org/10.1530/ERC-20-0149DOI Listing

Corneal calcium deposition as a plaque following collagen cross linking and vitamin D insufficiency.

Indian J Ophthalmol 2020 Jul;68(7):1441-1442

Eye Life, 204 Ram Krishna Chambers, Linking Road, Khar West, Mumbai, Maharashtra, India.

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http://dx.doi.org/10.4103/ijo.IJO_2160_19DOI Listing

Hyperparathyroidism (primary) NICE guideline: diagnosis, assessment, and initial management.

Br J Gen Pract 2020 Jul 25;70(696):362-363. Epub 2020 Jun 25.

National Guideline Centre, Royal College of Physicians, London.

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http://dx.doi.org/10.3399/bjgp20X710717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319687PMC

Effects of total parathyroidectomy treatment on parathyroid hormone levels, recurrent laryngeal nerve function, and the rate of infection complications of secondary hyperparathyroidism patients under image information health monitoring by magnetic resonance imaging.

Neurosci Lett 2020 Jun 22;735:135195. Epub 2020 Jun 22.

Department of Medical Imaging, 960 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Jinan, 250031, Shandong Province, China. Electronic address:

In order to explore the application of computer information health monitoring technology in the evaluation of the treatment effect after total parathyroidectomy (T-PTX) for patients with Secondary Hyperparathyroidism (SHPT), preoperative magnetic resonance imaging (MRI) computer health monitoring technology was used to locate and diagnose the parathyroid glands. Autotransplantation were performed. The changes of total intact parathyroid hormone (iPTH) before and after surgery, serum Calcium (Ca), serum phosphorus (P), and alkaline phosphatase (ALP) were observed and recorded. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135195DOI Listing

Tyrosine Kinase Inhibitors' Newly Reported Endocrine Side Effect: Pazopanib-Induced Primary Adrenal Insufficiency in a Patient With Metastatic Renal Cell Cancer.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620936808

University of Arizona, Phoenix, AZ, USA.

Tyrosine kinase inhibitors (TKIs) have been used in the treatment of multiple types of cancer. Pazopanib is one of the TKIs and is considered a first-line treatment for adult patients with metastatic renal cell carcinoma. Many endocrine-related adverse effects have been noted with the use of TKIs including hypothyroidism, vitamin D deficiency, altered bone density, secondary hyperparathyroidism, abnormal glucose metabolism, gynecomastia, and hypogonadism. Read More

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http://dx.doi.org/10.1177/2324709620936808DOI Listing

Cinacalcet-Associated Resolution of Primary Hyperparathyroidism in a Patient With Normal Kidney Function.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620936836

Department of Medicine, Albany Medical College, Albany, NY, USA.

Cinacalcet use is associated with risk of hypocalcemia; however, this risk has been mostly demonstrated in patients with chronic kidney disease. In this article, we describe a case of a 59-year-old male with primary hyperparathyroidism (PHPT), hypercalciuria, osteopenia, and normal kidney function who was started on cinacalcet for the management of recurrent hypercalcemia following prior unsuccessful parathyroidectomy. Within 6 months following cinacalcet commencement, he developed symptomatic and biochemical hypocalcemia requiring discontinuation of the medication and initiation of calcium supplementation. Read More

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http://dx.doi.org/10.1177/2324709620936836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318811PMC

A Preliminary Study of the Effect of Hyperadrenocorticism on Calcium and Phosphate Concentrations, Parathyroid Hormone and Markers of Bone Turnover in Dogs.

Front Vet Sci 2020 8;7:311. Epub 2020 Jun 8.

Small Animal Clinical Studies, School of Veterinary Medicine, University College Dublin, Dublin, Ireland.

Reports on the effects of hyperadrenocorticism (HAC) on bone turnover in dogs are largely confined to radiographic studies. The aim of this study was to more accurately assess bone turnover in dogs with HAC by measuring circulating total and ionized calcium and phosphate concentrations, both intact and whole parathyroid hormone (PTH) concentrations and markers of both osteoblastic (osteocalcin) and osteoclastic [carboxyterminal cross-linked telopeptide of type 1 collagen (ICTP) and urine aminoterminal telopeptide of type 1 collagen (NTX) activity]. Dogs with HAC and a control group were prospectively enrolled for comparison. Read More

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http://dx.doi.org/10.3389/fvets.2020.00311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294964PMC

Exacerbation of Hyperparathyroidism, Secondary to a Reduction in Kidney Function, in Individuals With Vitamin D Deficiency.

Front Med (Lausanne) 2020 5;7:221. Epub 2020 Jun 5.

Department of Social Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Chronic kidney disease (CKD)-mineral and bone disorders (CKD-MBD) are an adverse outcome derived from decreases in kidney function, where abnormality of serum concentrations of calcium (Ca), phosphorus, parathyroid hormone (PTH), and vitamin D can be seen simultaneously. To identify individuals at risk for CKD-MBD or secondary hyperparathyroidism, the relationships between estimated glomerular filtration rate (eGFR) and serum PTH concentration were evaluated, allowing for confounding factors, in particular vitamin D status, in a general Japanese population. Nine-hundred-and-thirty participants in the population-based Iwaki study conducted in 2016 who were not on drugs affecting mineral metabolism nor hemodialysis, were included in the study (326 men and 604 women; age: 55. Read More

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http://dx.doi.org/10.3389/fmed.2020.00221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289923PMC

Exogenous intoxication by non-prescribed use of vitamin D, a case report.

BMC Geriatr 2020 Jun 24;20(1):221. Epub 2020 Jun 24.

Internal Medicine Department, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.

Background: This case report, unlike the current literature related to vitamin D intoxication, aims to highlight the risk of self-medication, and how publicity boosts the acquisition of vitamins for different purposes, increasing consumption with no professional indication or supervision. This practice can pose a serious health risk to the population.

Case Presentation: Our patient, a brazilian retired 64-year-old female, presented to the emergency service with post-prandial food vomiting of undigested content and stabbing abdominal pain with worsening during palpation. Read More

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http://dx.doi.org/10.1186/s12877-020-01614-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315533PMC

Seven cases of parathyroid carcinoma and review of the literature.

Hormones (Athens) 2020 Jun 23. Epub 2020 Jun 23.

Department of Endocrinology and Metabolism, Marmara University School of Medicine, Istanbul, Turkey.

Parathyroid cancer is a rare malignancy and an uncommon cause of hyperparathyroidism. In the present study, we present seven cases of parathyroid carcinoma. The female ratio was 5/7 (71. Read More

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http://dx.doi.org/10.1007/s42000-020-00220-yDOI Listing

Imaging and Diagnostic Challenges in a Patient With Refractory Hypoglycemia Caused by Insulinomas Related to Multiple Endocrine Neoplasia Type 1.

Cureus 2020 May 20;12(5):e8208. Epub 2020 May 20.

Internal Medicine, University of Missouri Health Care, Columbia, USA.

Insulinoma is a rare neuroendocrine tumor. It may occur sporadically or as part of the genetic tumor syndrome multiple endocrine neoplasia type 1 (MEN1). Diagnosis is challenging because of the small size of insulin producing tumors that lead to hyperinsulinemia. Read More

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http://dx.doi.org/10.7759/cureus.8208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305576PMC

Multiple Uterine Leiomyomas in Multiple Endocrine Neoplasia Type 1 with a Novel MEN1 Gene Mutation.

J Hum Reprod Sci 2020 Jan-Mar;13(1):75-77. Epub 2020 Apr 7.

Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.

To report the clinical, hormonal, and genetic features of a female with multiple endocrine neoplasia type 1 (MEN1) with multiple uterine leiomyomas. The study was conducted at a tertiary care endocrinology unit. A 27-year-old female was diagnosed with prolactinoma, primary hyperparathyroidism (PHPT), and multiple uterine leiomyomas. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_42_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295258PMC

GERMLINE MUTATION SCREENING IN CHINESE PRIMARY HYPERPARATHYROIDISM PATIENTS.

Endocr Pract 2020 Jun 23. Epub 2020 Jun 23.

From: Key laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Glial cell missing 2 (GCM2), the critical regulator in the development of parathyroid glands, has been associated with the pathogenesis of primary hyperparathyroidism (PHPT). Relevant data in Chinese and other Asian populations are still lacking. This study aimed to screen the germline mutations of in Chinese PHPT patients. Read More

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http://dx.doi.org/10.4158/EP-2020-0132DOI Listing

Parathyroid carcinoma in a 13-year-old girl with a long-term survival.

Surg Case Rep 2020 Jun 22;6(1):145. Epub 2020 Jun 22.

Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, Japan.

Background: Parathyroid carcinoma as a cause of primary hyperparathyroidism in children is extremely rare. We report a case of parathyroid carcinoma which occurred in a 13-year-old girl who survived for more than 45 years after the first operation.

Case Presentation: A woman was admitted to our hospital for the treatment of recurrent parathyroid carcinoma in the neck. Read More

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http://dx.doi.org/10.1186/s40792-020-00914-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310022PMC

Pediatric parathyroid disease.

Semin Pediatr Surg 2020 Jun 17;29(3):150923. Epub 2020 May 17.

Institutional affiliation: Phoenix Children's Hospital; Departments of Surgery and Child Health, Univeristy of Arizona, Phoenix, AZ; Department of Surgery, Creighton University School of Medicine, Phoenix, AZ; Departments of Surgery and Pediatrics, Mayo Clinic Arizona, Phoenix, AZ. Electronic address:

Parathyroid glands are critical for calcium and phosphate homeostasis. Parathyroid disease is relatively rare in the pediatric population, but there are some important pediatric-specific considerations and conditions. This article reviews parathyroid physiology, disorders of hyper- and hypo- function, operative management, and uniquely pediatric diagnoses such as neonatal severe hyperparathyroidism. Read More

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http://dx.doi.org/10.1016/j.sempedsurg.2020.150923DOI Listing

Multimodal imaging in sclerochoroidal calcification: a case report and literature review.

BMC Ophthalmol 2020 Jun 22;20(1):248. Epub 2020 Jun 22.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.

Background: Sclerochoroidal calcification (SCC), a rare condition found in elderly people, is idiopathic or occasionally secondary to disorders affecting calcium metabolism. Findings of multimodal imaging including choroidal circulation are, however, largely unknown. We present a patient of SCC with systemic background, who underwent multimodal imaging evaluations. Read More

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http://dx.doi.org/10.1186/s12886-020-01520-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310239PMC

Parathyroid Cell Proliferation in Secondary Hyperparathyroidism of Chronic Kidney Disease.

Int J Mol Sci 2020 Jun 18;21(12). Epub 2020 Jun 18.

The Wohl Institute for Translational Medicine, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel.

Secondary hyperparathyroidism (SHP) is a common complication of chronic kidney disease (CKD) that correlates with morbidity and mortality in uremic patients. It is characterized by high serum parathyroid hormone (PTH) levels and impaired bone and mineral metabolism. The main mechanisms underlying SHP are increased PTH biosynthesis and secretion as well as increased glandular mass. Read More

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http://dx.doi.org/10.3390/ijms21124332DOI Listing

Warfarin-induced impairment of bone material quality in a patient undergoing maintenance hemodialysis: A case report.

Medicine (Baltimore) 2020 Jun;99(25):e20724

Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University.

Introduction: The use of warfarin in patients undergoing hemodialysis is associated with decreased bone mineral density and an increased incidence of bone fracture. However, no studies to date have directly estimated bone quality with bone histomorphometry in patients with bone abnormalities who are taking warfarin and undergoing hemodialysis.

Patient Concerns: A 47-year-old female with Noonan syndrome presented with progressive bilateral lower extremity pain on walking, and skin sclerosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000020724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310883PMC

Combined versus subtraction-only technique in parathyroid scintigraphy: effect on scan interpretation.

Nucl Med Commun 2020 Jun 18. Epub 2020 Jun 18.

Node for Infection Imaging, Central Analytical Facilities, Stellenbosch University, Cape Town, South Africa.

Introduction: Parathyroidectomy is the choice of treatment for patients with primary and tertiary hyperparathyroidism. Scintigraphic, preoperative localization of hyperfunctioning parathyroid tissue depends on either a delayed washout technique, a subtraction technique, or a combination of the two. The rationale for adopting a combination approach is its presumed superior sensitivity, but there is limited evidence to support this strategy at the cost of patient inconvenience and impact on departmental workflows. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001239DOI Listing

[Choroidal calcification associated to chondrocalcinosis].

Rev Med Inst Mex Seguro Soc 2019 09 2;57(2):324-328. Epub 2019 Sep 2.

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Oftalmología, Servicio de Oftalmología. Ciudad de México, México.

Introduction: Chondrocalcinosis is a common joint condition in people over 50, characterized by the deposition of calcium pyrophosphate crystals that causes calcification in cartilage structures. Although its prevalence in the general population is 5%, sclerochoroidal calcifications are a rare finding in this pathology.

Objective: Describe the case of a 60-year-old man with choroidal calcification in the left eye, associated with radiological findings of chondrocalcinosis, whose metabolic report showed parameters compatible with hyperparathyroidism. Read More

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September 2019

The silver lining: pleural calcification in an end-stage renal disease patient with tertiary hyperparathyroidism.

J R Coll Physicians Edinb 2020 Jun;50(2):164-165

Department of Internal Medicine, Hospital Tuanku Fauziah, Perlis, Malaysia.

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http://dx.doi.org/10.4997/JRCPE.2020.219DOI Listing

Vitamin D and PTH: data from a cross-sectional study in an equatorial population.

Endocr Connect 2020 Jun 1. Epub 2020 Jun 1.

J Felício, Hospital Universitário João de Barros Barreto, Belem, 66073-000, Brazil.

Objective: Investigate the prevalence of vitamin D deficiency in an equatorial population through a large-sample study.

Methods: Cross-sectional study with 30,224 healthy individuals from the North Region, in Brazil (Amazônia, state of Pará), who had 25-hydroxy-vitamin D (25(OH)D) and intact parathyroid hormone (PTH) serum levels measured by immunoassay method. Those with history of acute or chronic diseases were excluded. Read More

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http://dx.doi.org/10.1530/EC-20-0206DOI Listing