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    1 OF 574

    Significance of parathyroid scintigraphy and correlation of findings with parathyroid hormone values in patients undergoing hemodialysis.
    Med Glas (Zenica) 2017 Aug 1;14(2). Epub 2017 Aug 1.
    Clinic for Gynecology and Obstetrics, University Clinical Center Sarajevo; Bosnia and Herzegovina.
    Aim To compare finding of thyroid gland scintigraphy with serum concentration of parathyroid hormone in patients undergoing hemodialysis. Methods This retrospective-prospective study included 50 patients undergoing hemodialysis with established hyperparathyroidism who were treated at Cantonal Hospital Zenica in the period 2009 - 2014. Besides anthropological data, concentration of parathyroid hormone in serum of patients was monitored too. Read More

    [Asymptomatic primary hyperparathyroidism in women].
    Medicina (B Aires) 2017 ;77(3):196-200
    Instituto de Investigaciones Metabólicas, Universidad del Salvador, Buenos Aires, Argentina.
    Primary hyperparathyroidism may have different characteristics. One is the asymptomatic form. This is a mild variant of hypercalcemic hyperparathyroidism, characterized by a calcemia not greater than 1 mg/dl above the upper limit of the method, a high intact parathyroid hormone (iPTH), absence of renal stones, renal function impairement, and osteoporosis, less than 50 years of age, and less than 400 mg/day calciuria. Read More

    Comparison of Intact PTH and Bio-Intact PTH Assays Among Non-Dialysis Dependent Chronic Kidney Disease Patients.
    Ann Lab Med 2017 Sep;37(5):381-387
    Department of Nephrology and Hypertension, Meir Medical Center, Kfar Saba, Israel.
    Background: The third-generation bio-intact parathyroid hormone (PTH) (1-84) assay was designed to overcome problems associated with the detection of C-terminal fragments by the second-generation intact PTH assay. The two assays have been compared primarily among dialysis populations. The present study evaluated the correlations and differences between these two PTH assays among patients with chronic kidney disease (CKD) stages 3 to 5 not yet on dialysis. Read More

    A role for TET2 in parathyroid carcinoma.
    Endocr Relat Cancer 2017 Jul;24(7):309-318
    Department of Surgical SciencesEndocrine Unit, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Primary hyperparathyroidism (pHPT) is rarely caused by parathyroid carcinoma (PC, <1-5% of pHPT cases). The TET proteins oxidize the epigenetic mark 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and inactivation by mutation or epigenetic deregulation of TET1 and TET2 play important roles in various cancers. Recently, we found that 5hmC was severely reduced in all of the analyzed PCs and with deranged expression of TET1 for the majority of PCs. Read More

    Selective venous sampling for primary hyperparathyroidism: how to perform an examination and interpret the results with reference to thyroid vein anatomy.
    Jpn J Radiol 2017 Jun 21. Epub 2017 Jun 21.
    Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, 1197-1 Yasashicho, Asahi-ku, Yokohama, Kanagawa, 241-0811, Japan.
    Primary hyperparathyroidism (pHPT) causes hypercalcemia. The treatment for pHPT is surgical dissection of the hyperfunctioning parathyroid gland. Lower rates of hypocalcemia and recurrent laryngeal nerve injury imply that minimally invasive parathyroidectomy (MIP) is safer than bilateral neck resection. Read More

    Acute airway compromise due to parathyroid tumour apoplexy: an exceptionally rare and potentially life-threatening presentation.
    BMC Endocr Disord 2017 Jun 21;17(1):35. Epub 2017 Jun 21.
    Department of Endocrinology, Beaumont Hospital, Dublin, Ireland.
    Background: Spontaneous haemorrhage into a parathyroid adenoma is a rare and potentially life-threatening presentation.

    Case Presentation: We report the case of a 45 year old female recently diagnosed with primary hyperparathyroidism who presented with chest discomfort and acute airway compromise due to spontaneous extracapsular haemorrhage into a parathyroid adenoma. Computed tomography (CT) imaging showed a hypopharyngeal haematoma extending 10 cm into the superior mediastinum. Read More

    To assess the effects of parathyroidectomy (TPTX versus TPTX+AT) for Secondary Hyperparathyroidism in chronic renal failure: A meta-analysis.
    Int J Surg 2017 Jun 17. Epub 2017 Jun 17.
    Department of General Surgery, Chang Zheng Hospital Affiliated to Second Military Medical University, Shanghai 200003, China.
    Background: Secondary Hyperparathyroidism (SHPT) requiring parathyroidectomy (PTX) occurs more commonly in patients with progressive chronic kidney disease and in those on long-term lithium therapy. Successful PTX often results in a dramatic drop of parathyroid hormone level, relieves the patient from clinical symptoms, and reduces mortality. However, there is an ongoing debate on the optimal surgical treatment of SHPT. Read More

    Use of CTX-I and PINP as bone turnover markers: National Bone Health Alliance recommendations to standardize sample handling and patient preparation to reduce pre-analytical variability.
    Osteoporos Int 2017 Jun 19. Epub 2017 Jun 19.
    ETL Consulting, Seattle, WA, 98177, USA.
    N-terminal propeptide of type I procollagen and C-terminal telopeptide of type I collagen are the reference standards for bone turnover markers for monitoring osteoporosis treatment. We provide recommendations for standardized sample handling and encompassing aspects of preanalytical variability to improve the reproductibility of their measurements, their reliability, and clinical interpretation. The International Osteoporosis Foundation and International Federation of Clinical Chemistry bone turnover marker standards working group have identified N-terminal propeptide of type I procollagen (PINP) and C-terminal telopeptide of type I collagen (CTX-I) in the blood to be the international reference standards for bone turnover markers for the prediction of fracture risk and monitoring of osteoporosis treatment. Read More

    Anti-inflammatory profile of paricalcitol in kidney transplant recipients.
    Nefrologia 2017 Jun 13. Epub 2017 Jun 13.
    Unidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, España; Servicio de Nefrología, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, España. Electronic address:
    Background And Objectives: Paricalcitol, a selective vitamin D receptor activator, is used to treat secondary hyperparathyroidism in kidney transplant patients. Experimental and clinical studies in non-transplant kidney disease patients have found this molecule to have anti-inflammatory properties. In this exploratory study, we evaluated the anti-inflammatory profile of paricalcitol in kidney-transplant recipients. Read More

    Bone mineral disturbances in patients with chronic kidney disease stage 5 not yet on dialysis.
    Clin Nephrol 2017 Jun 16. Epub 2017 Jun 16.
    Aims: This retrospective study evaluates the success of a treatment strategy for secondary hyperparathyroidism in our cohort of patients with chronic kidney disease stage 5 who were not yet on dialysis.

    Materials And Methods: 81 predialysis patients from the outpatient clinic of the Department of Nephrology, University Medical Center Ljubljana were reviewed. We focused on serum markers for bone mineral metabolism including intact parathyroid hormone (PTH), phosphate, corrected calcium, and the usage of phosphate-binding agents and vitamin D analogs. Read More

    Incidence of Parathyroid Disorders in an Indian Adult Male Population: A 25 year follow up study.
    Clin Endocrinol (Oxf) 2017 Jun 15. Epub 2017 Jun 15.
    Departments Pediatrics, Army Hospital (Research & Referral), Delhi, 110010.
    Context And Objective: Detailed information on the epidemiology of parathyroid disorders in India is lacking. Most of the available data pertain to primary hyperparathyroidism (PHPT) rather than the overall burden of parathyroid disorders. We studied the incidence of parathyroid disorders in a cohort of service personnel followed for a long duration. Read More

    Systematic review of oral manifestations related to hyperparathyroidism.
    Clin Oral Investig 2017 Jun 14. Epub 2017 Jun 14.
    Experimental Surgery and Regenerative Medicine, Ludwig-Maximilians-Universität, Munich, Germany.
    Objectives: We sought to identify oral symptoms found in hyperparathyroidism and compare their rate of occurrence, as well as potential variations in sequelae between primary, secondary, and tertiary hyperparathyroidism.

    Materials And Methods: Database searches were performed through EMBASE and PubMed, with a continual handsearch for relevant articles. PRISMA guidelines were followed. Read More

    Treatment of secondary hyperparathyroidism: the clinical utility of etelcalcetide.
    Ther Clin Risk Manag 2017 1;13:679-689. Epub 2017 Jun 1.
    Department of Health Sciences, Renal Division, University of Milan, ASST Santi Paolo e Carlo, San Paolo Hospital, Milan.
    Secondary hyperparathyroidism (SHPT), a very frequent, severe, and worsening complication of chronic kidney disease, is characterized by high serum parathyroid hormone (PTH), parathyroid gland hyperplasia, and disturbances in mineral metabolism. Clinically, SHPT shows renal osteodystrophy, vascular calcification, cardiovascular damage, and fatal outcome. Calcium-sensing receptor (CaSR) is the main physiological regulator of PTH secretion; its activation by calcium rapidly inhibits PTH. Read More

    Value of 99mTc-MIBI SPECT/CT parathyroid imaging and ultrasonography for concomitant thyroid carcinoma.
    Nucl Med Commun 2017 Jun 13. Epub 2017 Jun 13.
    Departments of aNuclear Medicine bEndocrine and Metabolic Diseases, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
    Purpose: We aimed to assess the frequency of carcinoma in cases with suspected parathyroid adenoma and test the value of Tc-methoxyisobutylisonitrile (Tc-MIBI) single-photon emission computed tomography/computed tomography (SPECT/CT) parathyroid imaging and neck ultrasonography in detecting concomitant thyroid carcinoma.

    Patients And Methods: We enrolled 741 patients with clinically suspected parathyroid adenoma who underwent Tc-MIBI planer scans and SPECT/CT of the skull base, neck, and thorax; patients also underwent ultrasonography within 1 month before SPECT/CT. Each case with suspected lesion was analyzed and correlated with pathology. Read More

    Parathyroid surgery: from inception to the modern day.
    Br J Hosp Med (Lond) 2017 Jun;78(6):333-337
    Consultant Ear, Nose and Throat Surgeon, Department of Otorhinolaryngology-Head and Neck Surgery, Hull Teaching Hospitals NHS Trust, Castle Hill Hospital, Cottingham, East Yorkshire HU16 5JQ.
    Parathyroid surgery has undergone great changes since its inception less than a century ago. It is still the only definitive option available to cure primary or tertiary hyperparathyroidism. This review details the development of parathyroid surgery, our understanding of hyperparathyroidism and the treatment options available. Read More

    Specifying the molecular pattern of sporadic parathyroid tumorigenesis-The Y282D variant of the GCM2 gene.
    Biomed Pharmacother 2017 Jun 9;92:843-848. Epub 2017 Jun 9.
    Department of Oncological Surgical and Gastroenterological Sciences (DiSCOG), University of Padova, Padova, Italy.
    Objective: Sporadic carcinoma of the parathyroid glands is a rare malignant neoplasia. The GCM2 gene encodes a transcription factor that is crucial to embryonic parathyroid development. The Y282D variant of GCM2 exhibits increased transcriptional activity, and the presence of this variant is significantly associated with a higher prevalence of primitive hyperparathyroidism. Read More

    The impact of VDR expression and regulation in vivo.
    J Steroid Biochem Mol Biol 2017 Jun 9. Epub 2017 Jun 9.
    Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, United States. Electronic address:
    The vitamin D receptor (VDR) mediates the pleiotropic biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). These actions include orchestration of mineral homeostasis which is coordinated by the kidney, intestine, bone and parathyroid gland wherein the VDR transcriptionally regulates expression of the genes involved in this complex process. Mutations in human VDR (hVDR) cause hereditary vitamin D resistant rickets, a genetic syndrome characterized by hypocalcemia, hyperparathyroidism and rickets resulting from dysregulation of mineral homeostasis. Read More

    Hypercalcemia due to Nasopharyngeal Carcinoma.
    JNMA J Nepal Med Assoc 2017 Jan-Mar;56(205):182-185
    Department of Pediatrics & Adolescent Medicine, BP Koirala Institute of Health Sciences, Dharan, Nepal.
    Hypercalcemia is a rare metabolic disorder associated with hyperparathyroidism, malignancy and various other causes. Although common in adult malignancies, hypercalcemia is rare in pediatrics and purports poor prognosis. Nasopharyngeal carcinoma is rare with no reported hypercalcemic presentation. Read More

    MEN1 mutations and potentially MEN1-targeting miRNAs are responsible for menin deficiency in sporadic and MEN1 syndrome-associated primary hyperparathyroidism.
    Virchows Arch 2017 Jun 8. Epub 2017 Jun 8.
    "Lendület" Hereditary Endocrine Tumours Research Group, Hungarian Academy of Sciences, Semmelweis University, Szentkirályi utca 46, Budapest, H-1088, Hungary.
    Inherited, germline mutations of menin-coding MEN1 gene cause multiple endocrine neoplasia type 1 (MEN1), while somatic MEN1 mutations are the sole main driver mutations in sporadic primary hyperparathyroidism (PHPT), suggesting that menin deficiency has a central role in the pathogenesis of PHPT. MiRNAs are small, noncoding RNAs posttranscriptionally regulating gene expression. Our aim was to investigate both the role of MEN1 mutations and potentially MEN1-targeting miRNAs as the underlying cause of menin deficiency in MEN1-associated and sporadic PHPT tissues. Read More

    Oxidative stress and angiogenesis in primary hyperparathyroidism.
    Eur Surg 2017 14;49(3):118-126. Epub 2016 Dec 14.
    School of Medicine with the Division of Dentistry, Department of General and Endocrine Surgery, Medical University of Silesia, Bytom, Poland.
    Background: The inappropriate elevation of parathormone (PTH), which regulates the process of angiogenesis in parathyroid tissue, causes the changes of activity of enzymes responsible for the removal of free radicals. Parathyroidectomy (PTX) in patients with primary hyperparathyroidism (PHPT) lowers the level of PTH and leads to the reduction of risk of cardiovascular and all-cause mortality by normalization of the antioxidant status. Therefore, the aims of the study were to assess the activity of antioxidant enzymes and free radical reaction products in patients after parathyroidectomy, and to evaluate the correlation between the systemic oxidative stress and angiogenic parameters. Read More

    Vitamin D levels strongly influence bone mineral density and bone turnover markers during weight gain in female patients with anorexia nervosa.
    Int J Eat Disord 2017 Jun 7. Epub 2017 Jun 7.
    Department of Medicine, Rheumatology Unit, University of Verona, Piazzale L.A. Scuro 10, Verona, 37026, Italy.
    Objective: The aim of the study was to investigate a potential role for vitamin D status on bone mineral density (BMD) during weight gain in patients with anorexia nervosa (AN).

    Method: Spine and hip BMD assessed by dual-energy X-ray absorptiometry (DXA), serum vitamin D (25-OH-D), N-propeptide of type I collagen (P1NP), C-terminal telopeptide of type I collagen (CTX), and intact parathyroid hormone (PTH) were measured before and after a 20-week intensive weight-restoration program in ninety-one female patients with AN and secondary amenorrhoea.

    Results: Ninety-one consecutive female patients (age 13-45 years; weight 39. Read More

    Single Large Bladder Stone in a Young Male Adult with Primary Hyperparathyroidism.
    Urol Case Rep 2017 Jul 1;13:162-164. Epub 2017 Jun 1.
    Faculty of Medicine, King Abdullah University Hospital, Ar Ramtha, Jordan.
    Bladder stones are caused when minerals are built up in the bladder, especially if the bladder is incompletely emptied. These stones will pass while they are small. Otherwise, they get stuck to the bladder wall or ureter. Read More

    Dietary Intake and Weight Changes 5 Years After Laparoscopic Sleeve Gastrectomy.
    Obes Surg 2017 Jun 6. Epub 2017 Jun 6.
    School of Nutrition and Health Sciences, Taipei Medical University, No 250, Wuxing St, Xinyi District, Taipei, 110, Taiwan.
    Background: Laparoscopic sleeve gastrectomy (LSG) is becoming a leading primary bariatric surgery but long-term outcome remains unclear. The amount of food eaten is drastically reduced after LSG and may lead to nutritional deficiencies potentially. The aim of this study is to investigate long-term dietary intake and weight status after LSG. Read More

    [What would you do with an adult patient who consults due to head muscle weakness and has dropped head?]
    Semergen 2017 Jun 3. Epub 2017 Jun 3.
    Medicina Familiar y Comunitaria, CAP Guineueta, Atención Primaria, Institut Català de la Salut, Barcelona, España.
    The dropped head syndrome, whether due to muscle weakness, rigidity, or ankylosis, is not uncommon in the elderly. It is characterised by a "chin-on-chest" reducible kyphosis, which is secondary to head muscle debility. It may be associated with a neuromuscular group of diseases such as polymyositis, chronic Inflammatory demyelinating polyneuropathy, myasthenia gravis, amyotrophic lateral sclerosis, and inclusion-body myositis. Read More

    The age of developing diabetes and FTO polymorphisms (rs9939609, rs1421085, and rs9930506).
    Endokrynol Pol 2017 Jun 6. Epub 2017 Jun 6.
    Department of Internal Medicine, Diabetology and Nephrology in Zabrze, Medical University of Silesia in Katowice.
    Introduction: Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong genetic predisposition. Fat mass and obesity-associated protein (FTO) is one of the genes of interest to us. Hypomethylation of a CpG site in the FTO gene was significantly associated with the risk of T2DM. Read More

    Prospective cohort study: Cinacalcet-mediated lowering of PTH level and cardiovascular disease mortality in younger Korean patients with stage 5 CKD at a Korean secondary hospital.
    J Clin Pharm Ther 2017 Jun 5. Epub 2017 Jun 5.
    College of Pharmacy, Duksung Women's University, Seoul, Korea.
    What Is Known And Objectives: Cinacalcet may reduce cardiovascular disease (CVD) mortality in elderly patients with chronic kidney disease (CKD). However, previous studies of the clinical responses to cinacalcet have exhibited discrepancies due to highly variable baseline levels of parathyroid hormone (PTH), kidney function and age. Little is known about the true effect of cinacalcet on stage 5 CKD. Read More

    Benign and Malignant Thyroid Gland Diseases in the Patients with Primary Hyperparathyroidism.
    Int J Appl Basic Med Res 2017 Apr-Jun;7(2):117-120
    Department of Endocrinology and Metabolism, Medical Faculty, Trakya University, Edirne, Turkey.
    Introduction: This study aimed to evaluate concurrently detected thyroid pathologies in the patients who underwent surgery for primary hyperparathyroidism (PHPT).

    Materials And Methods: In this study, we retrospectively analyzed the files of the patients who underwent surgery for PHPT between 2012 and 2015. Pre- and post-operative laboratory examination results and preoperative radiological and nuclear medicine findings of the patients were retrospectively recorded. Read More

    Progression of Osteoporosis After Kidney Transplantation in Patients With End-Stage Renal Disease.
    Transplant Proc 2017 Jun;49(5):1033-1037
    Transplant Research Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. Electronic address:
    Background: This study investigated the prevalence of osteoporosis and the risk factors for its progression in kidney transplant recipients (KTRs).

    Methods: Dual energy X-ray absorptiometry was used to prospectively measure changes in bone mineral density (BMD) before kidney transplantation (KT) and 1 year after transplantation in 207 individuals. We also analyzed the risk factors of osteoporosis progression during this period. Read More

    [Maxillary, buccal and dental expressions of hyperparathyroidisms].
    Presse Med 2017 Jun 1. Epub 2017 Jun 1.
    CHU de Lille, Lille, France.
    States of chronic parathyroid hypersecretion, related to a primitive parathyroid abnormality (adenoma, hyperplasia), or to a cause of chronic calcipenia (renal failure, vitamin D deficiency…) have a major impact on bone remodeling, alveolodental structures. Thinning of the lamina dura, maxillary or mandibular brown tumors, giant cell epulis are the most emblematic signs of the primary hyperparathyroidism. Other expressions are related to genetic factors such as fibrous tumors of the jaw in conjunction with mutations in the gene coding for parafibromin. Read More

    A novel surgical strategy for secondary hyperparathyroidism: Purge parathyroidectomy.
    Int J Surg 2017 May 31;43:112-118. Epub 2017 May 31.
    Department of General Surgery, Chang Zheng Hospital Affiliated to Second Military Medical University, Shanghai 200003, China.
    Objective: This study was intended to demonstrate the feasibility and efficacy of purge parathyroidectomy (PPTX) for patients with secondary hyperparathyroidism (SHPT).

    Methods: The "seed, environment, and soil" medical hypothesis was first raised, following review of the literatures, to demonstrate the possible causes of persistence or recurrence of SHPT after parathyroidectomy. Subsequently, the novel surgical strategy of PPTX was proposed, which involves comprehensive resection of the fibro-fatty tissues, including visible or invisible parathyroid, within the region surrounded by the thyroid cartilage, bilateral carotid artery sheath, and the brachiocephalic artery. Read More

    Tumoral calcinosis: diffuse multifocal form in hemodialysis patients. Two case reports.
    Orthop Traumatol Surg Res 2017 May 30. Epub 2017 May 30.
    Service de Néphrologie, Dialyse et Transplantation Rénale, Hôpital Militaire Mohammed V, Rabat, Morocco.
    Orthopedic surgeons are often consulted for diagnosis of MASS (mitral valve prolapse, aortic enlargement, skin and skeletal findings) syndrome, imaging showing periarticular calcification, or joint stiffness. Such presentations in a dialyzed patient should suggest tumoral calcinosis, which is a rare complication of dialysis, often diagnosed wrongly or late. It is often associated with calcium phosphate balance disorder, in which treatment is difficult and must take account of known contributing factors: severe hyperparathyroidism, increased phosphocalcic product, therapeutic calcium and vitamin D overload, and bone turnover slowed for varying reasons. Read More

    Uremic Toxicity and Bone in CKD.
    J Nephrol 2017 Jun 1. Epub 2017 Jun 1.
    Division of Nephrology, Endocrinology and Metabolism, Department of Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
    Patients with chronic kidney disease (CKD), especially those on dialysis treatment, are at high risk of bone fracture. In CKD-mineral and bone disorder (CKD-MBD), secondary hyperparathyroidism in patients with advanced CKD induces bone abnormalities, and skeletal resistance to parathyroid hormone (PTH) starts in the early stages of kidney disease. Uremic toxins such as indoxyl sulfate and p-cresyl sulfate reduce the expression of PTH receptor as well as PTH-induced cyclic adenosine 3',5' monophosphate production in osteoblasts. Read More

    Hypercalcaemia - presentation and management .
    Clin Med (Lond) 2017 Jun;17(3):270-273
    Department of Diabetes & Endocrinology, Norfolk and Norwich University Hospital; Norwich Medical School; NIHR CRN:Eastern Research Network, Norwich, UK.
    Hypercalcaemia is a common disorder normally caused by primary hyperparathyroidism (PHPT) or malignancy. A proportion of cases present as an emergency, which carries a significant mortality. Emergency management of hypercalcaemia is based on intravenous rehydration with normal saline but when this is inadequate, bisphosphonate therapy is used; more recently the novel anti-resorbtive agent denosumab has been shown to have a useful role in treatment. Read More

    Papillary carcinoma of the thyroid in patients with primary hyperparathyroidism: Is there a link?
    Med Hypotheses 2017 Jun 26;103:100-104. Epub 2017 Apr 26.
    Diabetes and Endocrinology, Thomas Addison Unit, St George's Healthcare NHS Trust, London, UK. Electronic address:
    Primary hyperparathyroidism (PHPT) is present in up to 0.1% of the general population. The incidence is higher in women and increases with age. Read More

    Can ARFI elastography be used to differentiate parathyroid from thyroid lesions?
    J Endocrinol Invest 2017 May 31. Epub 2017 May 31.
    Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.
    Objectives: To assess if elasticity score (ES) and shear wave velocity (SWV) measurement obtained using ARFI elastography can differentiate between parathyroid lesions and thyroid nodules.

    Materials And Methods: ARFI elastography was performed on patients with primary hyperparathyroidism or solid thyroid nodules who were being considered for surgery using virtual touch quantification and virtual touch imaging (VTI) software. Only patients with surgical histopathology (47 parathyroid lesions, 38 benign thyroid nodules and 55 malignant thyroid nodules) were included for final analysis. Read More

    Challenging Differential Diagnosis of Hypergastremia and Hyperglucagonemia with Chronic Renal Failure: Report of a Case with Multiple Endocrine Neoplasia Type 1.
    Intern Med 2017 1;56(11):1375-1381. Epub 2017 Jun 1.
    Department of Diabetes and Endocrinology, Osaka Red Cross Hospital, Japan.
    A 53-year-old woman developed end-stage renal failure during a 15-year clinical course of primary hyperparathyroidism and was referred to our hospital for evaluation of suspected multiple endocrine neoplasia type 1 (MEN1). Genetic testing revealed a novel deletion mutation at codon 467 in exon 10 of the MEN1 gene. Systemic and selective arterial calcium injection (SACI) testing revealed hyperglucagonemia and hypergastrinemia with positive gastrin responses. Read More

    Sensitive Detection of a Small Parathyroid Adenoma Using Fluorocholine PET/CT: A Case Report.
    Nucl Med Mol Imaging 2017 Jun 20;51(2):186-189. Epub 2016 Sep 20.
    Department of Nuclear Medicine, PGIMER, Sector-12, Chandigarh, 160012 India.
    Primary hyperparathyroidism is caused by parathyroid adenoma in the majority of cases and diagnosis is usually made biochemically. Pre-surgical localization of parathyroid adenoma is essential to limit the extent of surgery and avoid missing them at ectopic sites. Anatomical and functional imaging are used for the localization, but may fail to identify the small and ectopic parathyroid adenoma. Read More

    Imaging of Parathyroid Glands in End Stage Renal Disease.
    Semin Dial 2017 May 30. Epub 2017 May 30.
    Department of Surgery, Emory University School of Medicine, Atlanta, Georgia.
    Secondary hyperparathyroidism from chronic renal failure often requires a parathyroidectomy for correction. A successful parathyroidectomy often relies upon localization of all parathyroid tumors. Although most of the tumors are localized during a neck exploration, preoperative localization studies can help identify ectopic and supernumerary tumors. Read More

    Osteolytic lesions: osteitis fibrosa cystica in the setting of severe primary hyperparathyroidism.
    BMJ Case Rep 2017 May 28;2017. Epub 2017 May 28.
    General Medicine, Joondalup Health Campus, Joondalup, Western Australia, Australia.
    A 58-year-old female patient presented with several weeks history of significant bilateral knee pain. Initial knee radiographs demonstrated lucencies of the bony cortex while extensive osteolytic lesions on a routine chest radiograph were suggestive of multiple myeloma or bony metastases. Biochemical investigation revealed primary hyperparathyroidism with renal insufficiency. Read More

    Minimally invasive radioguided parathyroid surgery using low dose Tc-99m-MIBI: comparison with standard high dose.
    Endokrynol Pol 2017 May 29. Epub 2017 May 29.
    Surgical Oncology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad.
    Background: Surgery remains the most effective treatment for primary hyperparathyroidism (PHPT). Minimally invasive radioguided parathyroidectomy (MIRP) is a common technique for detecting and excising abnormal parathyroid glands. The aim of this study was to compare injections of low-dose and high-dose (99m) Tc methoxy isobutyl isonitrile (MIBI) for intraoperative localisation of parathyroid adenomas by means of a gamma probe in patients with primary hyperparathyroidism (PHPT). Read More

    Comparison of 18F-Fluorocholine Positron Emission Tomography/Computed Tomography and Four-dimensional Computed Tomography in the Preoperative Localization of Parathyroid Adenomas-initial Results.
    Indian J Endocrinol Metab 2017 May-Jun;21(3):399-403
    Department of Surgery, All India Institute of Medical Sciences, New Delhi, India.
    Objective: We aimed to compare the diagnostic accuracy of 18F-Fluorocholine (FCH)-positron emission tomography/computed tomography (PET/CT) and four-dimensional (4D)- CT in detection and localization of eutopic and ectopic parathyroid adenoma (PA) in patients with hyperparathyroidism.

    Materials And Methods: Five patients with primary hyperparathyroidism underwent FCH-PET/CT after 60 min of 185 MBq of intravenous 18F-FCH administration. Images were acquired from head to mediastinum at 3 min per bed position. Read More

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