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    1 OF 584

    Thirty-day readmissions following parathyroidectomy: Evidence from the National Readmissions Database, 2013-2014.
    Am J Otolaryngol 2018 Jan 10. Epub 2018 Jan 10.
    University of Miami Miller School of Medicine, Miami, FL, USA.
    Purpose: Parathyroidectomy is one of the most common procedures performed in the United States, and are increasingly being performed safely in the outpatient setting. However, complications from surgery can be life-threatening, and thus an understanding of who may be at risk is essential. We analyzed and compared the risk factors for patients readmitted within 30 days following inpatient parathyroidectomy for primary or secondary hyperparathyroidism. Read More

    Dual energy computed tomography should be a first line preoperative localization imaging test for primary hyperparathyroidism patients.
    Am J Surg 2018 Jan 5. Epub 2018 Jan 5.
    Department of Surgery, St. Paul's Hospital & University of British Columbia, Vancouver, BC, Canada. Electronic address:
    Background: The objective of this study was to evaluate the performance of dual-energy computed tomography (DECT) for preoperative parathyroid tumor (PT) localization in primary hyperparathyroid (PHP) patients.

    Methods: A retrospective review was carried out of the medical records of all PHP patients who underwent ultrasound (US), Tc-99m sestamibi noncontrast single photon emission computed tomography (CT-MIBI), DECT and parathyroidectomy at a single center.

    Results: The sensitivities and accuracies for preoperative PT localization in the 97 patient study population were: US 40% and 93%, CT-MIBI 64. Read More

    Current opinions on nephrolithiasis associated with primary hyperparathyroidism.
    Urolithiasis 2018 Jan 19. Epub 2018 Jan 19.
    Department of Urology, Jiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China.
    Nephrolithiasis is a common urological disease and could be secondary to primary hyperparathyroidism (PHPT). PHPT is traditionally characterised with hypercalcaemia. Recently, a normocalcemic PHPT has been officially recognised at the International Workshops. Read More

    Undiagnosed Primary Hyperparathyroidism and Recurrent Miscarriage: The First Prospective Pilot Study.
    World J Surg 2018 Jan 18. Epub 2018 Jan 18.
    Department of Endocrine and Thyroid Surgery, Hammersmith Hospital, Imperial College London, London, UK.
    Background: Primary hyperparathyroidism (pHPT) in pregnancy is reported to be associated with significant maternal and foetal complications and an up to threefold increase in the risk of miscarriage. However, the true incidence of pHPT in pregnancy, complete and miscarried, is unknown and there are no data on the prevalence of undiagnosed pHPT in recurrent miscarriage (RM) (≥3 consecutive miscarriages under 24-week gestation). This is the first prospective study aiming to establish the prevalence of undiagnosed pHPT in RM. Read More

    A Longitudinal Study of 25-Hydroxy Vitamin D and Parathyroid Hormone Status throughout Pregnancy and Exclusive Lactation in New Zealand Mothers and Their Infants at 45° S.
    Nutrients 2018 Jan 13;10(1). Epub 2018 Jan 13.
    Department of Human Nutrition, University of Otago, Dunedin 9054, New Zealand.
    Vitamin D status and associated metabolism during pregnancy and lactation have been assessed in only a limited number of longitudinal studies, all from the northern hemisphere, with no infant data concurrently reported. Therefore, we aimed to describe longitudinal maternal and infant 25-hydroxy vitamin D (25OHD) and parathyroid hormone (PTH) status during pregnancy and up to 5 months postnatal age, in New Zealand women and their infants living at 45° S latitude. Between September 2011 and June 2013, 126 pregnant women intending to exclusively breastfeed for at least 20 weeks were recruited. Read More

    Nuclear Medicine Methods for Evaluation of Abnormal Parathyroid Glands in Patients with Primary and Secondary Hyperparathyroidism.
    Folia Med (Plovdiv) 2017 Dec;59(4):396-404
    4Complex Oncology Center, Plovdiv, Bulgaria.
    Considered rare disease in the past, primary hyperparathyroidism (PHPT) has dramatically increased in incidence over the past thirty years with the introduction of routine calcium measurements; it is now approximately 42 per 100 000 persons. By far, the most common lesion found in patients with PHPT is the solitary parathyroid adenoma, occurring in 85%-90% of patients, while in the rest 10%- 15% primary hyperplasia of the parathyroid glands is present. Currently, the most widely used surgical approach is minimally invasive parathyroidectomy which is associated with less post-surgery complications and shorter operation time. Read More

    Paricalcitol Versus Calcifediol for Treating Hyperparathyroidism in Kidney Transplant Recipients.
    Kidney Int Rep 2018 Jan 28;3(1):122-132. Epub 2017 Sep 28.
    Department of Nephrology, Hospital 12 de Octubre, Madrid, Spain.
    Introduction: Secondary hyperparathyroidism (SHPT) and vitamin D deficiency are common at kidney transplantation and are associated with some early and late complications. This study was designed to evaluate whether paricalcitol was more effective than nutritional vitamin D for controlling SHPT in de novo kidney allograft recipients.

    Methods: This was a 6-month, investigator-initiated, multicenter, open-label, randomized clinical trial. Read More

    18F-choline PET/CT for parathyroid scintigraphy: significantly lower radiation exposure of patients in comparison to conventional nuclear medicine imaging approaches.
    J Radiol Prot 2018 Jan 17. Epub 2018 Jan 17.
    Department for Nuclear Medicine, University Medical Centre Ljubljana, Zaloska 7, Ljubljana, 1525, SLOVENIA.
    Background: Parathyroid subtraction scintigraphy is the most commonly used imaging method for localization of hyperfunctioning parathyroid glands (HPG) in primary hyperparathyroidism, a common endocrine disorder. Hybrid (SPECT/CT) imaging with 99mTc-sestaMIBI (MIBI) at an early and delayed phase (dual-phase imaging) may be the most accurate conventional imaging approach, but includes additional radiation exposure due to added CT imaging. Recently, 18F-choline (FCH) PET/CT was introduced for HPG imaging, which can also be performed using the dual-phase approach. Read More

    Combined use of a nanocarbon suspension and 99mTc-MIBI for the intra-operative localization of the parathyroid glands.
    Am J Otolaryngol 2017 Dec 13. Epub 2017 Dec 13.
    Department of Head and Neck Surgery, RenJi Hospital, Shanghai JiaoTong University, School of Medicine, Shanghai 200001, China. Electronic address:
    Objective: To investigate the combined use of a nanocarbon (NC) suspension and low-dose 99mTc-MIBI for parathyroid localization during surgery in patients with secondary hyperparathyroidism (sHPT).

    Methods: Between March 2010 and September 2015, 40 patients with sHPT were enrolled in this study and were randomized to receive either low-dose 99mTc-MIBI+NC (group I) or low-dose 99mTc-MIBI (group II). Pre- and post-operative serum levels of intact PTH (iPTH), calcium and phosphorus between groups were compared and the intra-operative radioactive counts of the parathyroid glands were measured. Read More

    Risk Factors for Elevated Preoperative Alkaline Phosphatase in Patients with Refractory Secondary Hyperparathyroidism.
    Am Surg 2017 Dec;83(12):1368-1372
    Elevated preoperative levels of alkaline phosphatase (ALP) in patients with refractory secondary hyperparathyroidism are correlated with postoperative hypocalcemia and mortality. The aim of this study was to identify the predictors of preoperative ALP in patients with secondary hyperparathyroidism. From April 2012 to December 2015, 220 patients with refractory secondary hyperparathyroidism undergoing total parathyroidectomy without autotransplantation were reviewed. Read More

    Multiple invasive cervical resorption and celiac disease: A case report.
    Quintessence Int 2018 Jan 15:1-6. Epub 2018 Jan 15.
    Multiple invasive cervical resorption (MICR) is a rare disease of unknown etiology. A case of a patient with MICR of six teeth, with low vitamin D3 level detected, is presented. Applied surgical and general treatments were only partially effective, as they failed to stop the resorption, although the parameters of calcium-phosphate management appreciably improved, and secondary hyperparathyroidism was successfully resolved. Read More

    Persistent hyperparathyroidism as a risk factor for long-term graft failure: the need to discuss indication for parathyroidectomy.
    Surgery 2018 Jan 10. Epub 2018 Jan 10.
    Renal Transplantation Service, São Paulo University School of Medicine, São Paulo, Brazil; Nephrology Division, São Paulo University School of Medicine, São Paulo, Brazil.
    Background: Although a successful kidney transplant (KTx) improves most of the mineral and bone disorders (MBD) produced by chronic kidney disease (CKD), hyperparathyroidism may persist (pHPT). Current guidelines recommend parathyroidectomy if serum parathormone is persistently elevated 1 year after KTx, because pHPT has been recently associated with poor graft outcomes. However, whether patients with pHPT and adequate renal function are at risk for long-term graft failure is unknown. Read More

    Diagnosis, management, histology and genetics of sporadic primary hyperparathyroidism: old knowledge with new tricks.
    Endocr Connect 2018 Jan 12. Epub 2018 Jan 12.
    F Palazzo, Department of Thyroid and Endocrine Surgery, Imperial College London, London, UK, London, United Kingdom of Great Britain and Northern Ireland.
    Primary hyperparathyroidism (pHPT) is a common endocrinopathy resulting from inappropriately high PTH secretion. It usually results from the presence of a single gland adenoma, multiple gland hyperplasia or rarely parathyroid carcinoma. All these conditions require different management and it is important to be able to differentiate the underlined pathology, in order for the clinicians to provide the best therapeutic approach. Read More

    Baseline and pre-operative 1-year mortality risk factors in a cohort of 509 hip fracture patients consecutively admitted to a co-managed orthogeriatric unit (FONDA Cohort).
    Injury 2018 Jan 6. Epub 2018 Jan 6.
    Department of Geriatric Medicine, Hospital Universitario la Paz, Paseo de la Castellana 261, 28046, Madrid, Spain; Instituto de Investigación Biomédica del Hospital Universitario La Paz (IdiPAZ), Paseo de la Castellana 261, 28046, Madrid, Spain; Reticef, Spain; Department of Medicine, Universidad Autónoma de Madrid, Arzobiso Morcillo 4, 28029, Madrid, Spain.
    Introduction: The aim of this study was to determine the patient characteristics that predict 1-year mortality after a hip fracture (HF).

    Methods: All patients admitted consecutively with fragility HF during 1 year in a co-managed orthogeriatric unit of a university hospital (FONDA cohort) were assesed. Baseline and admission demographic, clinical, functional, analytical and body-composition variables were collected in the first 72 h after admission. Read More

    Parafibromin-deficient (HPT-JT Type, CDC73 Mutated) Parathyroid Tumors Demonstrate Distinctive Morphologic Features.
    Am J Surg Pathol 2018 Jan 10. Epub 2018 Jan 10.
    Sydney Medical School, University of Sydney, Sydney.
    The gene CDC73 (previously known as HRPT2) encodes the protein parafibromin. Biallelic mutation of CDC73 is strongly associated with malignancy in parathyroid tumors. Heterozygous germline mutations cause hyperparathyroidism jaw tumor syndrome,which is associated with a high life-time risk of parathyroid carcinoma. Read More

    Serum Parathyroid Hormone and 25-Hydroxyvitamin D Concentrations Before and After Biliopancreatic Diversion.
    Obes Surg 2018 Jan 10. Epub 2018 Jan 10.
    Endocrinology and Nephrology Unit, CHU de Québec Research Centre, Quebec City, Quebec, Canada.
    Background: Biliopancreatic diversion with duodenal switch (BPD-DS) decreases vitamin D and calcium absorption, which may result in secondary hyperparathyroidism. This study aimed at evaluating the prevalence of vitamin D deficiency and secondary hyperparathyroidism before and after BPD-DS.

    Methods: A retrospective analysis of patients who had undergone BPD-DS at a tertiary bariatric center between 2003 and 2010 and for whom simultaneous measurements of serum 25-hydroxyvitamin D and parathyroid hormone were available within 5 years post-op was performed. Read More

    Diagnostic accuracy of planar, SPECT, and SPECT/CT parathyroid scintigraphy protocols in patients with hyperparathyroidism.
    Nucl Med Rev Cent East Eur 2018 Jan 10. Epub 2018 Jan 10.
    Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Khon Kaen University, Thailand, 123, Mittraparb road, 40000 Khon Kaen, Thailand.
    Background: Several parathyroid scintigraphy protocols have been used for preoperative localization of hyperfunctioning parathyroid glands in patients with hyperparathyroidism. The aim of this study is to compare the diagnostic accuracy of various parathyroid scintigraphy protocols.

    Material And Methods: A retrospective diagnostic accuracy study with histopathology as the reference standard was done. Read More

    Coagulation and fibrinolysis in hyperparathyroidism secondary to vitamin D deficiency.
    Endocr Connect 2018 Jan 9. Epub 2018 Jan 9.
    V Gerdes, Internal Medicine, Medical Center Slotervaart, Amsterdam, Netherlands.
    Introduction: Abnormal coagulation tests have been observed in patients with primary hyperparathyroidism (HPT) suggesting a prothrombotic effect of parathyroid hormone (PTH). Vitamin D deficiency (VIDD) is the most frequent cause of secondary HPT. Aim of our study was to investigate the influence of HPT secondary to moderate-severe VIDD and vitamin D replacement on the coagulation and fibrinolysis system. Read More

    Comparison of video-assisted thoracic surgery with open surgery in the treatment of ectopic mediastinal parathyroid tumors.
    J Thorac Dis 2017 Dec;9(12):5171-5175
    Department of thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
    Background: To investigate the therapeutic effect of different surgical treatment for ectopic mediastinal parathyroid tumors and pathological features.

    Methods: A total of 21 patients who were diagnosed with ectopic mediastinal parathyroid tumors and underwent surgeries in our department from May 1995 to May 2015 were collected and retrospectively analyzed.

    Results: Twenty-one patients including 8 female (36. Read More

    Secondary hyperparathyroidism causing increased jaw bone density and mandibular pain: a case report.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Dec 7. Epub 2017 Dec 7.
    OMFS-IMPATH Research Group, Department Imaging & Pathology, Faculty of Medicine, University Leuven, Leuven, Belgium; Department of Oral and Maxillofacial Surgery, Leuven University Hospitals, Leuven, Belgium.
    We present the case of a 32-year-old male patient complaining of recurrent mandibular pain for 3.5 years. Panoramic radiography indicated increased cortical density of the mandibular lower border. Read More

    Sestamibi SPECT/CT versus SPECT only for preoperative localization in primary hyperparathyroidism: a single institution 8-year analysis.
    Surgery 2018 Jan 5. Epub 2018 Jan 5.
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
    Background: Primary hyperparathyroidism is caused by single gland disease in 85% of cases and by multiglandular disease in 15%. Our aim was to discover if the addition of computed tomography acquisition/fusion on a hybrid scanner to traditional dual-phase single-photon emission tomography improves localization accuracy.

    Methods: A prospective database was queried for the perioperative data of patients with sporadic primary hyperparathyroidism who had initial exploration from 2006-2014 with ≥6 month follow-up to define anatomy. Read More

    Effect of calcifediol treatment on cardiovascular outcomes in patients with acute coronary syndrome and percutaneous revascularization.
    Med Clin (Barc) 2018 Jan 3. Epub 2018 Jan 3.
    Unidad de Gestión Clínica de Cardiología, Hospital Universitario Virgen de Valme, Sevilla, España.
    Background And Objectives: Vitamin D deficiency has been consistently linked with cardiovascular diseases. However, results of intervention studies are contradictory. The aim of this study was to evaluate the effect of treatment with calcifediol (25(OH)D3) on the cardiovascular system of patients with non-ST-elevation acute coronary syndrome after percutaneous coronary intervention. Read More

    Parathyroid hormone in washout fluid seems to be superior to cytology for localization of the lesion in MIBI-negative patients with primary hyperparathyroidism
    Turk J Med Sci 2017 Dec 19;47(6):1703-1707. Epub 2017 Dec 19.
    Background/aim: Primary hyperparathyroidism (PHPT) is characterized by increased calcium (Ca) and parathyroid hormone (PTH) levels. Surgical removal of the culprit hyperfunctioning parathyroid gland is the preferred treatment. In this study, we aimed to determine whether PTH-washout or cytological examination of suspicious lesions was superior in MIBI-negative patients diagnosed with PHPT. Read More

    Effects of oral paricalcitol therapy on arterial stiffness and osteopontin in hypertensive patients with chronic kidney disease and secondary hyperparathyroidism.
    Hellenic J Cardiol 2018 Jan 3. Epub 2018 Jan 3.
    First Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece.
    Background: Arterial stiffness is linked to the progression of atherosclerosis, while activation of vitamin D receptor exerts favorable cardiovascular effects in patients with renal insufficiency. In this study, we investigated the effects of oral treatment with paricalcitol, a potent vitamin D receptor activator on arterial stiffness and osteopontin, a marker of atherosclerosis, in hypertensive patients with chronic kidney disease (CKD) and secondary hyperparathyroidism.

    Methods: We followed up 29 treated hypertensive patients (mean age 74. Read More

    Synchronous parathyroid adenoma and papillary thyroid carcinoma: 99mTc-MIBI Scan Findings.
    Niger J Clin Pract 2017 Nov;20(11):1510-1512
    Department of Radiology, Cumhuriyet University Hospital, Sivas, Turkey.
    Simultaneous existence of parathyroid adenoma and thyroid nonmedullary carcinoma is rarely observed. A 52-year-old female was diagnosed approximately 4 years ago with primary hyperparathyroidism (PHPT) on the basis of hypercalcemia and elevated serum parathyroid hormone (PTH) level. Clinically, PHPT diagnosed patient was examined with Tc-99m MIBI scintigraphy to investigate parathyroid adenoma. Read More

    Near total parathyroidectomy for the treatment of renal hyperparathyroidism.
    Gland Surg 2017 Dec;6(6):638-643
    General Surgery Unit, Azienda Ospedaliero-Universitaria di Pisa, Pisa, Italy.
    Background: Different surgical strategies are used to treat medical refractory renal hyperparathyroidism. Our preferred choice in patients with moderate secondary hyperparathyroidism (SHPT) and in patients with low compliance with medical treatment is to leave a very small parathyroid remnant in situ: we name this operation "near total parathyroidectomy" (ntPTX). We report here our results with this technique. Read More

    Dietary imbalances in a large breed puppy, leading to compression fractures, vitamin D deficiency, and suspected nutritional secondary hyperparathyroidism.
    Can Vet J 2018 Jan;59(1):36-42
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.
    A 6-month-old intact female giant schnauzer dog fed a nutritionally unbalanced homemade diet was evaluated because of a 1-month history of lameness and difficulty walking. Abnormalities identified on ancillary tests, in conjunction with the dog's clinical improvement following diet change, suggested a diagnosis of vitamin D deficiency and nutritional secondary hyperparathyroidism. This report underlines the importance of appropriate feeding management, especially during the vulnerable growth phase. Read More

    Gallstones were associated with the gastrointestinal adverse events of cinacalcet in hemodialysis patients with secondary hyperparathyroidism.
    Ren Fail 2018 Nov;40(1):38-42
    a Department of Internal Medicine, Oshima Clinic , Saitama , Japan.
    This study aimed to investigate the association of gastrointestinal (GI) adverse events of cinacalcet with gallstones in the hemodialysis (HD) patients with secondary hyperparathyroidism (SHPT). A total of 23 HD patients under the treatment with cinacalcet and 101 control patients were enrolled in this cross-sectional study. We investigated the prevalence of gallstones and the association of GI adverse events of cinacalcet with gallstones. Read More

    J Zoo Wildl Med 2017 Dec;48(4):1120-1126
    The importance of vitamin D3 has been documented in multiple reptile species, with deficiencies resulting in alterations in calcium homeostasis, including nutritional secondary hyperparathyroidism. Though vitamin D3 can be obtained directly from dietary sources or from photobiosynthetic production, species variability in diet and behavior makes exposure to ultraviolet B (UVB) radiation an essential requirement for some diurnal species. The effect of different bulbs to promote synthesis of cholecalciferol (vitamin D3) in the bearded dragon ( Pogona vitticeps) was evaluated. Read More

    Addison disease and normocalcemic primary hyperparathyroidism in a dog with multiple endocrine neoplasia.
    Open Vet J 2017 5;7(4):332-336. Epub 2017 Dec 5.
    Cátedra de Patología, Fac. de Ciencias Veterinarias, UBA, Av. Chorroarín 280, Ciudad Autónoma de Buenos Aires, Argentina.
    A 12-year old dog with a 9-year history of primary adrenal insufficiency was referred to the service for hyporexia, muscle weakness, polyuria and polydipsia. Ultrasound examination showed an unresectable mass in the left adrenal gland, with local vascular invasion, which prompted the euthanasia of the animal. Additionally, necropsy revealed a nodular lesion in the right adrenal gland and enlargement of one of the four parathyroid glands. Read More

    Predictors of multiglandular disease in primary hyperparathyroidism.
    Langenbecks Arch Surg 2018 Jan 2. Epub 2018 Jan 2.
    Department of Clinical Sciences, Lund University, Lund, Sweden.
    Background: Primary hyperparathyroidism (pHPT) is caused by single- or multiglandular disease (MGD). Patients with MGD have an increased risk of complications at surgery and for persistence and recurrence after surgery. The study evaluated whether preoperative clinical and biochemical characteristics could predict MGD in patients with pHPT. Read More

    Ectopic Undescended Parathyroid Adenoma-SPECT/CT Avoids False-Negative Interpretation on 99mTc-MIBI Dual-Phase Scintigraphy.
    Clin Nucl Med 2017 Dec 30. Epub 2017 Dec 30.
    From the Molecular Imaging and Therapy Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY.
    Undescended parathyroid adenomas are rare, and they are easily missed during neck exploration surgery in patients with hyperparathyroidism. Few reports have described ectopic parathyroid adenomas along the carotid arteries at or near the carotid bifurcation. These may be missed on planar Tc-MIBI dual-phase scintigraphy because of overlapping submandibular gland activity. Read More

    Role of Parathyroid Hormone in Determination of Fat Mass in Patients with Vitamin D Deficiency.
    Indian J Endocrinol Metab 2017 Nov-Dec;21(6):848-853
    Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
    Background: Obesity has become a global epidemic and it is rising is Asia. Vitamin D deficiency (VDD) is widely prevalent in the Indian subcontinent. Studies have linked VDD to obesity and shown correlation between parathyroid hormone (PTH), 25-hydroxy Vitamin D (25(OH)D), and fat mass (FM). Read More

    Timing of parathyroidectomy in kidney transplant candidates with secondary hyperparathryroidism: effect of pretransplant versus early or late post-transplant parathyroidectomy.
    Surgery 2017 Dec 25. Epub 2017 Dec 25.
    Core Facility Quality Management and Health Technology Assessment in Transplantation, Integrated Research and Treatment Facility Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany; General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany. Electronic address:
    Background: The timing of parathyroidectomy in kidney transplant candidates suffering from secondary hyperparathyroidism before versus early or late after transplantation remains controversial.

    Methods: The short-term follow-up cohort comprised 66 patients with 1-year post-transplant follow-up, while the long-term follow-up cohort contained 123 patients. Risk-adjusted identification of independent risk factors for compromised renal graft function (KDIGO stage ≥ IV) was performed using multivariable regression analysis adjusted for propensity score logits for parathyroidectomy before versus after renal transplantation. Read More

    Comparative Diagnostic Performance of Ultrasonography and 99mTc-Sestamibi Scintigraphy for Parathyroid Adenoma in Primary Hyperparathyroidism; Systematic Review and Meta- Analysis
    Asian Pac J Cancer Prev 2017 Dec 28;18(12):3195-3200. Epub 2017 Dec 28.
    Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Email:
    Objective: Ultrasonography (US) and parathyroid scintigraphy (PS) with 99mTc-MIBI are common methods for preoperative localization of parathyroid adenomas but there discrepancies exist with regard to diagnostic accuracy. The aim of the study was to compare PS and US for localization of parathyroid adenoma with a systematic review and meta-analysis of the literature. Methods: Pub Med, Scopus (EMbase), Web of Science and the reference lists of all included studies were searched up to 1st January 2016. Read More

    Non-functioning parathyroid cystic tumour: malignant or not? Report of a case.
    G Chir 2017 Sep-Oct;38(5):243-249
    Parathyroid carcinoma (PC) is a very rare endocrine tumour, usually characterized by symptoms such as a neck mass, dysphonia, severe hypercalcemia exceeding 140 mg/L and elevated serum parathyroid hormone levels, even more than 5 times the upper limit of normal. Non-functioning parathyroid cancer is extremely rare and, in this case, its pre-operative diagnosis is often difficult. A 54-year old female patient, referring dysphagia and dysphonia, underwent neck ultrasound and neck CT. Read More

    Effect of Prophylactic Calcitriol Administration on Serum Ionized Calcium Concentrations after Parathyroidectomy: 78 Cases (2005-2015).
    J Vet Intern Med 2017 Dec 27. Epub 2017 Dec 27.
    Department of Small Animal Clinical Studies, Michigan State University, East Lansing, MI.
    Background: Prophylactic administration of calcitriol has been suggested to mitigate the risk of hypocalcemia after parathyroidectomy. The effect of calcitriol on postoperative serum ionized calcium concentrations has not been evaluated in dogs after parathyroidectomy.

    Hypothesis/objectives: To determine the effect of prophylactic calcitriol administration on postoperative serum ionized calcium (iCa) concentrations in dogs with primary hyperthyroidism (PHPTH) treated by parathyroidectomy. Read More

    Sevelamer hydrochloride suppresses proliferation of parathyroid cells during the early phase of chronic renal failure in rats.
    Nephrology (Carlton) 2017 Dec 26. Epub 2017 Dec 26.
    Department of Nephrology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, China.
    Aim: We examined the effects of sevelamer on parathyroid cell proliferation and secondary hyperparathyroidism in rats following induction of early-phase early phase of chronic renal failure (CRF) by unilateral ureteral obstruction (UUO).

    Methods: For 5 days, rats in the control group received normal food, rats in the sevelamer group (SH) received control food plus 5% sevelamer, and rats in the low protein group (LP) received low protein food. Five rats of each group were sacrificed at baseline (d0). Read More

    Normocalcemic primary hyperparathyroidism associated with progressive cortical bone loss - A case report.
    Bone Rep 2017 Dec 10;7:152-155. Epub 2017 Oct 10.
    Roger Williams Medical Center, 825 Chalkstone Avenue, Providence, RI, USA.
    The existence of normocalcemic primary hyperparathyroidism (NPHP) was acknowledged at the Third and Fourth International Proceedings on primary hyperparathyroidism PHPT but data relating to its clinical presentation, natural history, and skeletal status were limited and there was no information nor guidelines as to definitive therapy. Herein are reported biochemical, hormonal, and densitometry data in a postmenopausal woman seen initially for osteoporosis who was found to have increased serum PTH levels and normal serum total and ionized calcium levels without evidence of secondary hyperparathyroidism. Over a seven year period, the patient exhibited continuing preferential cortical bone loss at the one-third site of the radius in the face of relatively stable readings at the lumbar spine and hip that led to a subtotal parathyroidectomy for parathyroid hyperplasia with resultant normalization of serum PTH. Read More

    Ambulatory surgery under local anesthesia for parathyroid adenoma: Feasibility and outcome.
    J Visc Surg 2017 Dec 21. Epub 2017 Dec 21.
    Chirurgie digestive et endocrinienne, CHU Dupuytren, 2, avenue Martin-Luther-King, 87000 Limoges, France. Electronic address:
    The aim of this study was to evaluate the results of ambulatory parathyroid resection performed under local anesthesia (LA).

    Material And Methods: Outpatients undergoing parathyroid adenoma resection by a focused approach under LA were included. Results were evaluated by intraoperative serum parathormone levels (ioPTH) and the balance of phosphate and calcium postoperatively, at 3 months, 1 year and at the point date. Read More

    Double hit! A unique case of resistant hypertension.
    BMJ Case Rep 2017 Dec 22;2017. Epub 2017 Dec 22.
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, NYU School of Medicine, New York City, New York, USA.
    A middle-aged woman with obesity, hyperlipidaemia and diet-controlled diabetes was referred for resistant hypertension. Her blood pressure (BP) was uncontrolled on five medications, including a diuretic. Physical exam revealed a systolic ejection murmur, and ECHO demonstrated moderate hypertrophy. Read More

    Successful parathyroidectomy guided by intraoperative parathyroid hormone monitoring for primary hyperparathyroidism is preserved in mild and moderate renal insufficiency.
    Surgery 2017 Dec 19. Epub 2017 Dec 19.
    Division of Endocrine Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL.
    Background: The effect of altered parathyroid hormone metabolism in renal insufficiency on intraoperative parathyroid hormone monitoring during parathyroidectomy is not well known. This study evaluates operative outcomes in patients undergoing parathyroidectomy guided by intraoperative parathyroid hormone monitoring for primary hyperparathyroidism with mild and moderate renal insufficiency.

    Methods: A retrospective review of prospectively collected data in 604 patients with sporadic primary hyperparathyroidism undergoing parathyroidectomy guided by intraoperative parathyroid hormone monitoring was performed. Read More

    F18-choline PET/CT guided surgery in primary hyperparathyroidism when ultrasound and MIBI SPECT/CT are negative or inconclusive: the APACH1 study.
    Eur J Nucl Med Mol Imaging 2017 Dec 22. Epub 2017 Dec 22.
    Department of Nuclear Medicine and Thyroid Unit, François Baclesse Cancer Centre, Caen, France.
    Purpose: To evaluate the sensitivity of F18-choline (FCH) PET/CT for parathyroid adenoma detection prior to surgery in patients with primary hyperparathyroidism and negative or inconclusive cervical ultrasound and Tc99m-sestaMIBI SPECT/CT.

    Methods: We conducted a prospective bicentric study (NCT02432599). All patients underwent FCH PET/CT. Read More

    Use of Cinacalcet and 99mTc-sestamibi Imaging During Pregnancy.
    J Endocr Soc 2017 Sep 1;1(9):1156-1159. Epub 2017 Sep 1.
    Metabolic Bone Diseases Unit, Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
    A case report is reviewed, in which two nontraditional interventions were used in a patient with gestational primary hyperparathyroidism: cinacalcet and technetium-99m methoxyisobutylisonitrile imaging. The rationale for these decisions is considered in view of the available data. Read More

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