32,273 results match your criteria Hyperparathyroidism


A germline c.1546dupC MEN1 mutation in an MEN1 family: A case report.

Medicine (Baltimore) 2021 Jun;100(25):e26382

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chung-Ang University, College of Medicine, Seoul, Korea.

Rationale: Multiple endocrine neoplasia type 1 (MEN1) is a rare tumor syndrome with an autosomal dominant inheritance, and genetic testing for MEN1 gene is important for both affected individuals and their relatives. We present a 2-person family affected by a germline c.1546dupC MEN1 mutation, and one of them had a full-spectrum of MEN-related endocrine tumors. Read More

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Parafibromin Abnormalities in Ossifying Fibroma.

J Endocr Soc 2021 Jul 8;5(7):bvab087. Epub 2021 May 8.

Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, CT 06030, USA.

Ossifying fibromas are very rare tumors that are sometimes seen as part of the hyperparathyroidism-jaw tumor syndrome (HPT-JT), which is caused by inactivating mutations of the tumor suppressor gene mutations have been identified in a subset of sporadic cases but aberrant expression of the encoded protein, parafibromin, has not been demonstrated in ossifying fibroma. We sought to determine if loss of parafibromin regularly contributes to the development of sporadic, nonsyndromic ossifying fibroma. We examined a series of 9 ossifying fibromas, including ossifying, cemento-ossifying, and juvenile active variants, for parafibromin protein expression by immunohistochemistry and for sequence abnormalities by Sanger sequencing and/or targeted AmpliSeq panel sequencing. Read More

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Differences in Clinicopathological Characteristics of Papillary Thyroid Carcinoma between Symptomatic and Asymptomatic Patients with Primary Hyperparathyroidism.

Int J Endocrinol 2021 31;2021:9917694. Epub 2021 May 31.

Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China.

Background: Popularization of cervical ultrasound led to higher detection of papillary thyroid carcinoma (PTC) and primary hyperparathyroidism (PHPT), as well as increasing percentage of asymptomatic PHPT in China. Although the coexistence of PTC and PHPT has been reported, it is unknown whether the clinicopathological features of PTC differ between asymptomatic and symptomatic PHPT patients.

Methods: We retrospectively reviewed the medical records of 304 PHPT patients treated in our hospital between January 2009 and July 2020, including 217 females and 87 males with the average age of 53. Read More

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Intramuscular tumoral calcinosis near the arteriovenous fistula mimicking acute infection.

Sci Prog 2021 Apr-Jun;104(2):368504211018560

Department of Orthopedics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, P.R. China.

Tumoral calcinosis is a kind of tumorous calcified masses, which may progress in patients with chronic renal failure. Uremic tumoral calcinosis in the brachioradialis muscle presented like acute infection of the arteriovenous fistula has not been previously reported. A 49-year-old man came to our hospital with a 9-year history of hemodialysis and secondary hyperparathyroidism. Read More

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Efficacy and safety of intravenous pamidronate for parathyroid hormone-dependent hypercalcemia in hospitalized patients.

J Clin Endocrinol Metab 2021 Jun 22. Epub 2021 Jun 22.

Endocrine Institute, Meir Medical Center, Kfar Saba, Israel, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Context: Bisphosphonates are effective for hypercalcemia of malignancy (HOM). Efficacy and safety data for bisphosphonates in parathyroid hormone-related hypercalcemia (PTHRH) are rare, including pamidronate, which is not indicated for this condition.

Objective: To evaluate the efficacy and safety of pamidronate for moderate-to-severe PTHRH. Read More

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Do patients with atypical parathyroid adenoma need a close follow-up?

J Clin Endocrinol Metab 2021 Jun 22. Epub 2021 Jun 22.

Endocrine Unit, University Hospital of Pisa, Pisa, Italy.

Context: Atypical parathyroid adenomas (APAs) are neoplasms with uncertain malignant potential but lack unequivocal histological signs of malignancy.

Objective: To retrospectively evaluate the clinical and biochemical profiles of patients with APA, the outcome after parathyroidectomy (PTX), and the presence of CDC73 germline and somatic mutations.

Design: Monocentric study on consecutive patients undergoing PTX for primary hyperparathyroidism (PHPT) between June 2000 and December 2020. Read More

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European multicentre study on outcome of surgery for sporadic primary hyperparathyroidism.

Br J Surg 2021 Jun;108(6):675-683

Multidisciplinary Unit of Metabolic, Endocrine and Thyroid Surgery, Department of Surgery, Université de Lorraine, Centre Hospitalier Régional Universitaire Nancy, Vandoeuvre-lès Nancy, France.

Background: International multicentre outcome studies of surgery for primary hyperparathyroidism (pHPT), especially for rate of conversion to bilateral neck surgery and persistent hypercalcaemia, are scarce.

Methods: Eurocrine® is a European database for endocrine surgery. Data are entered according to predefined data fields. Read More

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GHRH secretion from a pancreatic neuroendocrine tumor causing gigantism in a patient with MEN1.

Endocrinol Diabetes Metab Case Rep 2021 Jun 1;2021. Epub 2021 Jun 1.

Department of Endocrinology, Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK.

Summary: A male patient with a germline mutation in MEN1 presented at the age of 18 with classical features of gigantism. Previously, he had undergone resection of an insulin-secreting pancreatic neuroendocrine tumour (pNET) at the age of 10 years and had subtotal parathyroidectomy due to primary hyperparathyroidism at the age of 15 years. He was found to have significantly elevated serum IGF-1, GH, GHRH and calcitonin levels. Read More

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Elevated basal serum levels of calcitonin and simultaneous surgery of MEN2A-specific tumors.

Neoplasma 2021 Jun 23. Epub 2021 Jun 23.

Department of Oncologic and Urologic Surgery, The 903rd PLA Hospital, Wenzhou Medical University, Hangzhou, Zhejiang, China.

Multiple endocrine neoplasia type 2A (MEN2A) is a rare syndrome caused almost by germline RET mutation, and characterized by medullary thyroid carcinoma (MTC), in combination or not with pheochromocytoma (PHEO), hyperparathyroidism (HPTH), cutaneous lichen amyloidosis (CLA), and Hirschsprung's disease (HD). The basal serum calcitonin (Ctn)/carcinoembryonic antigen (CEA) levels are significantly correlated with the MTC stage. Metachronous surgery of MEN2A-specific tumors is a routine procedure. Read More

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Primary Hyperparathyroidism Masquerading as Acute Pancreatitis.

Horm Metab Res 2021 Jun 21;53(6):377-381. Epub 2021 Jun 21.

Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana, Punjab, India.

Acute pancreatitis as an initial manifestation of primary hyperparathyroidism (PHPT) is a rare occurrence and timely diagnosis of PHPT is crucial in preventing repeat attack of pancreatitis. The study aimed at evaluating the clinico-radiological profile of patients admitted with acute pancreatitis as the index presentation of PHPT and to determine the factors associated with development of severe pancreatitis. This series included retrospective analysis of medical records of 30 patients admitted with acute pancreatitis as initial manifestation of PHPT. Read More

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One in a billion: a patient with Marfan syndrome and familial hypocalciuric hypercalcaemia.

Endocrinol Diabetes Metab Case Rep 2021 Jun 1;2021. Epub 2021 Jun 1.

Department of Endocrinology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK.

Summary: Marfan syndrome is an autosomal dominant multisystem disorder that has an estimated incidence of 1 in 5000. It is caused by mutations in the FBN1 gene, which encodes the extracellular matrix protein type 1 fibrillin. Familial hypocalciuric hypercalcaemia (FHH), also inherited in an autosomal dominant pattern, is a rare benign disorder characterised by hypercalcaemia, hypocalciuria and relative hyperparathyroidism with normal or high plasma PTH levels, with an estimated incidence of between 1 in 10 000 to 1 in 100 000. Read More

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Isolated hypophosphataemia as an early marker of primary hyperparathyroidism.

Endocrinol Diabetes Metab Case Rep 2021 Jun 1;2021. Epub 2021 Jun 1.

Endocrinology and Diabetes, Mid-Yorkshire NHS Trust, Wakefield, England.

Summary: Primary hyperparathyroidism (PHPT) is a disease caused by overactive parathyroid glands with consequent hypercalcaemia. The main cause in 85-90% of the cases is the presence of a solitary parathyroid adenoma. The most common presentation is with asymptomatic hypercalcaemia diagnosed on routine biochemical testing. Read More

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[Normocalcemic with elevated post-operative parathormone in primary hyperpara-thyroidism: 9 case reports and literature review].

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Jun;53(3):573-579

Department of Endocrinology, China-Japanese Friendship Hospital, Beijing 100029, China.

Objective: To summarize and analyze the clinical characteristics of primary hyperpara-thyroidism (PHPT) with normocalcemic parathormone elevation (NPE) after surgical treatment, so as to improve the therapeutic ability and standardized post-operative follow-up of PHPT patients.

Methods: Nine patients who were diagnosed with PHPT in the Department of Endocrinology of China-Japan Friendship Hospital from August 2017 to November 2019 were selected as the subjects. They all developed NPE within 6 months after surgical treatment. Read More

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Tumor Volume Can Be Used as a Parameter Indicating the Severity of Disease in Parathyroid Cancer.

Endocr Pract 2021 Jan 16. Epub 2021 Jan 16.

Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

Objective: To determine whether tumor volume and tumor size are related to disease severity in parathyroid cancer (PC).

Methods: Patients treated for PC at our institution were retrospectively identified. Data were collected about clinical and pathologic characteristics, laboratory parameters, tumor volume, recurrence, metastasis, and mortality. Read More

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January 2021

Focused parathyroidectomy without intraoperative parathyroid hormone measurement in primary hyperparathyroidism: Still a valid approach?

Surgery 2021 Jun 15. Epub 2021 Jun 15.

Endocrine Surgical Unit, University of Sydney, St Leonards, New South Wales, Australia; Sydney Medical School, Faculty of Medicine and Health, University of Sydney, New South Wales, Australia; Cancer Genetics Unit, Kolling Institute, Sydney, New South Wales, Australia.

Background: Concern regarding suboptimal cure rates has led to some endocrine surgery units abandoning focused parathyroidectomy for primary hyperparathyroidism in favor of open bilateral neck exploration or making intraoperative parathyroid hormone estimation mandatory in focused parathyroidectomy. This study explores whether focused parathyroidectomy for radiologically localized primary hyperparathyroidism without intraoperative parathyroid hormone is still a valid approach.

Methods: Retrospective review of a tertiary referral endocrine surgery unit database. Read More

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New-Onset Hypercalcemia After Renal Transplant: An Infectious Etiology Beyond Persistent Hyperparathyroidism.

Exp Clin Transplant 2021 Jun 17. Epub 2021 Jun 17.

From the Department of Internal Medicine, School of Medicine, Ege University, Izmir, Turkey.

Pneumocystis jirovecii pneumonia is an opportunistic infection in kidney transplant recipients. It may be complicated by hypercalcemia. Here, we discuss a 59-year-old man who presented with respiratory symptoms and hypercalcemia. Read More

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Giant versus regular parathyroid adenoma: A retrospective comparative study.

Ann Med Surg (Lond) 2021 Jun 29;66:102454. Epub 2021 May 29.

Department of Special Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan.

Background: A fraction of Parathyroid Adenoma (PTA) is considered giant if they weigh more than 3.5 g. There is no clear consensus whether this subgroup has a distinct clinical or biochemical presentation that could have implications on PTA localization and management. Read More

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Optimization of dialysate bicarbonate in patients treated with online haemodiafiltration.

Clin Kidney J 2021 Mar 28;14(3):1004-1013. Epub 2020 May 28.

Department of Nephrology, Hospital Clínic Barcelona, Barcelona, Spain.

Background: Metabolic acidosis is a common problem in haemodialysis patients, but acidosis overcorrection has been associated with higher mortality. There is no clear definition of the optimal serum bicarbonate target or dialysate bicarbonate. This study analysed the impact of reducing dialysate bicarbonate from 35 to 32 mEq/L on plasma bicarbonate levels in a cohort of patients treated with online haemodiafiltration (OL-HDF). Read More

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The Interplay Between Nutrition, Metabolic, and Endocrine Disorders in Chronic Kidney Disease.

Semin Nephrol 2021 Mar;41(2):180-188

Renal Division, Brigham and Women's Hospital, Boston, MA. Electronic address:

The kidneys are responsible for maintaining our bodies' homeostasis through excretion, biodegradation, and synthesis of different hormones. Therefore, a decline in renal function often results in significant derangements in hormone levels. The most common metabolic and endocrine abnormalities seen in patients with chronic kidney disease include deficiencies in erythropoietin, calcitriol, triiodothyronine, testosterone, and estrogen. Read More

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Bone Histomorphometry and F-Sodium Fluoride Positron Emission Tomography Imaging: Comparison Between only Bone Turnover-based and Unified TMV-based Classification of Renal Osteodystrophy.

Calcif Tissue Int 2021 Jun 17. Epub 2021 Jun 17.

Department of Medicine, Kidney Center, Turku University Hospital, PL 52, Kiinamyllynkatu 4-8, 20521, Turku, Finland.

Bone biopsy is the gold standard for characterization of renal osteodystrophy (ROD). However, the classification of the subtypes of ROD based on histomorphometric parameters is not unambiguous and the range of normal values for turnover differ in different publications. F-Sodium Fluoride positron emission tomography (F-NaF PET) is a dynamic imaging technique that measures turnover. Read More

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Hypovitaminosis D in migrant children in Switzerland: a retrospective study.

Eur J Pediatr 2021 Jun 15. Epub 2021 Jun 15.

Pediatric Infectious Diseases Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

Cholecalciferol (vitamin D) is essentially known for its role in the phosphocalcic metabolism and its associated pathologies, such as rickets. In Switzerland, 35 to 50% of children are vitamin D deficient. Due to skin colour, poor nutrition, living conditions and cultural practices, migrant population is particularly at risk. Read More

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Bone and Mineral Disease in Kidney Transplant Recipients.

Clin J Am Soc Nephrol 2021 Jun 14. Epub 2021 Jun 14.

T Nickolas, Division of Nephrology, Columbia University Irving Medical Center, New York, United States

After kidney transplantation mineral and bone disorders are associated with higher risk of fractures and consequent morbidity and mortality. Disorders of calcium and phosphorus, vitamin D deficiency and hyperparathyroidism are also common. The epidemiology of bone disease has evolved over the past several decades due to changes in immunosuppressive regimens, mainly glucocorticoid minimization or avoidance. Read More

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Use and disparities in parathyroidectomy for symptomatic primary hyperparathyroidism in the Medicare population.

Surgery 2021 Jun 11. Epub 2021 Jun 11.

Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Background: Few studies assess use of parathyroidectomy among older adults with symptomatic primary hyperparathyroidism. Our objective was to determine national usage and disparities in parathyroidectomy for symptomatic primary hyperparathyroidism among insured older adults.

Methods: We identified older adult patients with symptomatic primary hyperparathyroidism using Medicare claims (2006-2017). Read More

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Association of parathyroidectomy with 5-year clinically significant kidney stone events in patients with primary hyperparathyroidism.

Endocr Pract 2021 Jun 11. Epub 2021 Jun 11.

Department of Surgery, Stanford University School of Medicine, Palo Alto, CA.

Objective: Patients with primary hyperparathyroidism (PHPT) are at increased risk of kidney stones. Guidelines recommend parathyroidectomy in PHPT patients with a history of stone disease. This study aimed to compare the 5-year incidence of clinically significant kidney stone events in patients with PHPT treated with parathyroidectomy vs. Read More

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Giant parathyroid adenoma diagnosed by brown tumour, a clinical manifestation of primary hyperparathyroidism: A case report.

J Pak Med Assoc 2021 Apr;71(4):1266-1269

Department of General Surgery, Sisli Hamidiye Etfal Medical Practice and Research Center, University of Health Sciences, Istanbul, Turkey.

Brown tumour (BT) is the pathological expression of osteitis fibrosa cystica which is caused due to primary and secondary hyperparathyroidism (HPT). It is a rare benign lesion of skeletal system that usually affects the facial bones, clavicles, ribs, pelvis and extremities. The purpose of this case report is to present the clinical, pathological and radiological findings of BT - rarely seen in adults - originating from the giant parathyroid adenoma and emerging as the first clinical sign of HPT. Read More

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Endocrine Dysfunction in Patients with Myotonic Dystrophy.

J Clin Endocrinol Metab 2021 Jun 14. Epub 2021 Jun 14.

Division of Endocrinology, Metabolism and Diabetes, University of Louisville, Louisville, KY.

Myotonic dystrophy is a dominantly inherited multisystem disorder that results from increased CTG repeats in the 3' region of the myotonic dystrophy protein kinase gene (DMPK). The mutant DMPK mRNA remains nuclear, and sequesters RNA-binding proteins including regulators of mRNA splicing. Myotonic dystrophy is characterized by a highly variable phenotype that includes muscle weakness and myotonia, and may affect the function of many Endocrine glands. Read More

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Hyperparathyroidism subsequent to radioactive iodine therapy for Graves' disease.

Head Neck 2021 Jun 14. Epub 2021 Jun 14.

Department of Otolaryngology-Head and Neck Surgery, Henry Ford Hospital, Detroit, Michigan, USA.

Background: The development of primary hyperparathyroidism (PHPT) after radioactive iodine (RAI) treatment for thyroid disease is poorly characterized. The current study is the largest reported cohort and assesses the disease characteristics of patients treated for PHPT with a history of RAI exposure.

Methods: A retrospective analysis comparing patients, with and without a history of RAI treatment, who underwent surgery for PHPT. Read More

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Moderate/subclinical calcium deficiency attenuates trabecular mass, microarchitecture and bone growth in growing rats.

Biochem Biophys Rep 2021 Jul 27;26:101033. Epub 2021 May 27.

Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow -226014, India.

Adequate dietary calcium (Ca) intake is essential for bone accretion, peak bone mass (PBM) attainment, bone quality and strength during the mammalian growth period. Severe Ca deficiency during growing age results in secondary hyperparathyroidism (SHPT) and poor bone quality and strength. However, the impact of moderate Ca deficiency during rats early growth period on bone health and the reversibility with supplementing calcium later in adult life remains unclear. Read More

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Synchronous incidental double parathyroid adenomas and papillary thyroid carcinoma: A case report with literature review.

Niger J Clin Pract 2021 Jun;24(6):954-963

Fellow, Breast and Endocrine Surgery, King Saud University, Riyadh, Saudi Arabia.

The association between parathyroid and thyroid diseases is not uncommon; however, the concurrent presence of parathyroid adenoma and thyroid cancer is rare. Awareness of this situation will enable clinicians to consider possible parathyroid pathology in patients with papillary thyroid cancer. The presence of parathyroid adenoma leading to primary hyperparathyroidism and the coexistence of thyroid papillary cancer is rare. Read More

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Cystic Parathyroid Adenomas: An Enigmatic Entity and Role of Tc-99 m Sestamibi Scintigraphy.

Endocr Pract 2021 Jun 13;27(6):614-620. Epub 2020 Dec 13.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India.

Objective: Functional cystic lesion of the parathyroid gland is a rare cause of primary hyperparathyroidism (PHPT). They have been postulated to arise from the hemorrhage and cystic degeneration in the parathyroid adenoma (PA). We intended to analyze their scintigraphic and histopathological findings since available literature is sparse. Read More

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