30,252 results match your criteria Hyperparathyroidism


Long-term effectiveness of cinacalcet in non-dialysis patients with chronic kidney disease and secondary hyperparathyroidism.

Kidney Res Clin Pract 2019 Apr 25;38(1). Epub 2019 Apr 25.

Pharmacy Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Background: Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease (CKD). Cinacalcet use is controversial in non-dialysis patients.

Methods: This retrospective observational study recruited patients receiving cinacalcet (off-label use) in 2010 and 2011. Read More

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http://dx.doi.org/10.23876/j.krcp.18.0088DOI Listing

Fleckenstein's hypothesis revisited: excessive myocardial calcification after prolonged high dose catecholamine treatment: a case report.

Eur Heart J Case Rep 2018 Dec 14;2(4):yty126. Epub 2018 Nov 14.

Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Universität des Saarlandes, Kirrberger Str., Geb. 41.1, Homburg/Saar, Germany.

Background: Myocardial calcification after prolonged highly dosed catecholamine treatment has been described experimentally. Here, we demonstrate myocardial calcifications by high-dose catecholamine treatment leading to chronic heart failure in patients.

Case Summary: A 62-year-old Caucasian woman presented with central pulmonary embolism, developing acute heart failure, and cardiogenic shock. Read More

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http://dx.doi.org/10.1093/ehjcr/yty126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426089PMC
December 2018
1 Read

Active Vitamin D in Chronic Kidney Disease: Getting Right Back Where We Started from?

Authors:
Lavinia Negrea

Kidney Dis (Basel) 2019 Mar 19;5(2):59-68. Epub 2018 Dec 19.

Renal Division, Department of Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.

Background: The vitamin D system is essential for optimal health in humans. Circulating calcitriol, a key metabolite in maintaining calcium and phosphorus homeostasis, is produced in the kidney. In kidney failure, calcitriol levels progressively decrease, contributing to the development of renal secondary hyperparathyroidism (SHPT). Read More

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http://dx.doi.org/10.1159/000495138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465695PMC

Failure to Diagnose and Treat Hyperparathyroidism Among Patients with Hypercalcemia: Opportunities for Intervention at the Patient and Physician Level to Increase Surgical Referral.

Oncologist 2019 Apr 24. Epub 2019 Apr 24.

Dallas Veterans Affairs Hospital, University of Texas Southwestern, Dallas, Texas, USA.

Background: Hyperparathyroidism is both underdiagnosed and undertreated, but the reasons for these deficiencies have not been described. The purpose of this study was to identify reasons for underdiagnosis and undertreatment of hyperparathyroidism that could be addressed by targeted interventions.

Materials And Methods: We identified 3,200 patients with hypercalcemia (serum calcium >10. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0424DOI Listing

Postsurgical Evaluation of Secondary Nephrogenic Hyperparathyroidism.

Curr Med Sci 2019 Apr 23;39(2):259-264. Epub 2019 Apr 23.

Department of Otolaryngology Head and Neck Surgery, the 5th Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519020, China.

Parathyroidectomy is useful for the treatment of secondary hyperparathyroidism (SHPT) caused by chronic renal failure. The following three types of parathyroidectomy can be performed: subtotal parathyroidectomy, total parathyroidectomy and total parathyroidectomy plus autologous transplantation (tPTX+AT). Each of the three types of surgery has advantages and disadvantages. Read More

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http://dx.doi.org/10.1007/s11596-019-2028-0DOI Listing

Focused Parathyroidectomy Under Local Anesthesia - A Feasibility Study.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):67-71

Department of Endocrine Surgery, CMC Hospital, Vellore, Tamil Nadu, India.

Purpose: We conducted this study to evaluate the feasibility, patient satisfaction, and cost of performing focused parathyroidectomy under local anesthesia (LA) and mild sedation, administered and monitored by a surgeon.

Materials And Methods: This was a prospective observational study of 30 patients with primary hyperparathyroidism (PHPT) undergoing a focused parathyroidectomy under LA and mild sedation at a single institution. The clinical features, gland weight, operating time, procedure time, postoperative pain scores, overall patient satisfaction, postoperative nausea and vomiting, analgesic requirements, complications, cost, and cure rates were documented. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_590_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446694PMC

A Comparison between Silent and Symptomatic Renal Stones in Primary Hyperparathyroidism.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):46-49

Department of Nephrology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India.

Background: Nephrolithiasis is a common complication of primary hyperparathyroidism (PHPT), and in a subgroup of patients stones are clinically silent. Patients with silent and symptomatic stones may differ biochemically. There is a scarcity of data available comparing patients with silent and symptomatic renal stones in PHPT. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_558_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446667PMC

Long-Term Efficacy and Safety of Evocalcet in Japanese Patients with Secondary Hyperparathyroidism Receiving Hemodialysis.

Sci Rep 2019 Apr 23;9(1):6410. Epub 2019 Apr 23.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Namics 301, 4-24-51 Takanawa, Minato-ku, Tokyo, 108-0074, Japan.

Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease (CKD), and as the disease progresses SHPT is associated with systemic consequences, termed CKD-mineral and bone disorder. Currently, cinacalcet is indicated for the treatment of SHPT; however, cinacalcet is associated with upper gastrointestinal adverse events. Evocalcet has been developed to address these issues, but the long-term safety and efficacy of evocalcet need to be evaluated. Read More

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http://dx.doi.org/10.1038/s41598-019-42017-zDOI Listing

The effectiveness of cinacalcet: a randomized, open label study in chronic hemodialysis patients with severe secondary hyperparathyroidism.

Ren Fail 2019 Nov;41(1):326-333

a Division of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital , Chulalongkorn University , Bangkok , Thailand.

Background: Secondary hyperparathyroidism (SHPT) is associated with high incidences of cardiovascular disease, bone fracture, and mortality. This study was conducted to demonstrate the effectiveness of cinacalcet treatment on chronic kidney disease-mineral bone disorder (CKD-MBD) markers in chronic hemodialysis patients with severe SHPT.

Methods: In phase 1, 30 adult HD patients were randomized to cinacalcet or control groups for 12 weeks to explore the achievement of >30% reduction of iPTH. Read More

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https://www.tandfonline.com/doi/full/10.1080/0886022X.2018.1
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http://dx.doi.org/10.1080/0886022X.2018.1562356DOI Listing
November 2019
1 Read

Activation of the calcium sensing receptor attenuates TRPV6-dependent intestinal calcium absorption.

JCI Insight 2019 Apr 23;5. Epub 2019 Apr 23.

Plasma calcium (Ca2+) is maintained by amending the release of parathyroid hormone and through direct effects of the Ca2+ sensing receptor (CaSR) in the renal tubule. Combined, these mechanisms alter intestinal Ca2+ absorption by modulating 1,25-dihydroxy vitamin D3 production, bone resorption, and renal Ca2+ excretion. The CaSR is a therapeutic target in the treatment of secondary hyperparathyroidism and hypocalcemia a common complication of calcimimetic therapy. Read More

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http://dx.doi.org/10.1172/jci.insight.128013DOI Listing

Transient thyroiditis after parathyroidectomy for tertiary hyperparathyroidism.

Neth J Med 2019 Apr;77(3):119-121

Department of Cardiology, Medical Centre Leeuwarden, Leeuwarden, the Netherlands.

Thyrotoxicosis due to thyroiditis is predominantly caused by infection or autoimmune disease of the thyroid. Parathyroid surgery however, is a lesser known cause of thyroiditis, due to thyroid manipulation. We treated a patient who developed transient symptomatic thyroiditis following parathyroid surgery for tertiary hyperparathyroidism. Read More

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Direct bone effects of calcimimetics in chronic kidney disease?

Kidney Int 2019 May;95(5):1012-1014

Ospedale Universitario Policlinico Umberto I, Rome, Italy.

Calcimimetics are widely used in patients on dialysis to treat secondary hyperparathyroidism. Our current view is that bone effects are only indirect through parathyroid hormone suppression. However, because bone cells express the calcium-sensing receptor, direct calcium-sensing receptor-mediated effects are also possible. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538193027
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http://dx.doi.org/10.1016/j.kint.2019.01.045DOI Listing
May 2019
1 Read

Parathyroid Hormone and Cardiac Electrophysiology: A Review.

Cardiol Rev 2019 Apr 12. Epub 2019 Apr 12.

Calcium has long been known to be essential to cardiac electrical activity. Parathyroid hormone (PTH) is the main regulator of serum calcium and is central to calcium homeostasis. Although there are significant data linking parathyroid disease states with changes in cardiac electrophysiology, most data have focused on how PTH modulates serum calcium to produce these effects. Read More

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http://dx.doi.org/10.1097/CRD.0000000000000250DOI Listing

Orthopedic and orthodontic management in a patient with DiGeorge Syndrome and Familial Mediterranean Fever: A case report.

Spec Care Dentist 2019 Apr 22. Epub 2019 Apr 22.

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Aim: The aim of this study is to report the case of the orthopedic and orthodontic treatment in a young patient affected by DiGeorge Syndrome and Familial Mediterranean Fever.

Case Report: An 8-year-old boy with dysmorphic facial features was brought to our observation. Anamnesis revealed signs of fetal respiratory distress, previous surgically removed subdural hematoma, recurrent episodes of fever, arthralgia, polyserositis, hepatosplenomegaly, chronic interstitial nephritis with hypertension, microprotenuria, normocytic anemia, hyperparathyroidism and secondary amyloidosis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/scd.12381
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http://dx.doi.org/10.1111/scd.12381DOI Listing
April 2019
1 Read

American Head and Neck Society Endocrine Surgery Section update on parathyroid imaging for surgical candidates with primary hyperparathyroidism.

Head Neck 2019 Apr 19. Epub 2019 Apr 19.

Division of Head and Neck Endocrine Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland.

Health care consumer organizations and insurance companies increasingly are scrutinizing value when considering reimbursement policies for medical interventions. Recently, members of several American Academy of Otolaryngology-Head & Neck Surgery (AAO-HNS) committees worked closely with one insurance company to refine reimbursement policies for preoperative localization imaging in patients undergoing surgery for primary hyperparathyroidism. This endeavor led to an AAO-HNS parathyroid imaging consensus statement (https://www. Read More

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http://dx.doi.org/10.1002/hed.25781DOI Listing
April 2019
1 Read

Appearances of soft tissue calcification on Tc99m MDP bone scan.

J Pak Med Assoc 2019 Apr;69(4):600

Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.

Metastatic calcification relates to abnormal calcification resulting from hypercalcaemia in otherwise normal tissues. Hypercalcaemia can occur secondary to chronic renal failure, hyperparathyroidism, hypervitaminosis D, and metastatic neoplasms. Specific symptoms are often lacking, but calcification may be a marker of disease severity and its chronicity. Read More

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Characteristics of parathyroid hormone-1 receptor agonists and antagonists.

Future Med Chem 2019 Apr 18. Epub 2019 Apr 18.

Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.

Parathyroid hormone-1 receptor (PTH1R) is a member of B G protein-coupled receptors. The agonistic activation of the PTH1R results in the production and secretion of osteoclast-stimulating cytokines while antagonists may be used to treat bone metastases, hypercalcemia, cachexia and hyperparathyroidism. We built pharmacophore models and investigated the characteristics of PTH1R agonists and antagonists. Read More

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http://dx.doi.org/10.4155/fmc-2018-0508DOI Listing

Primary hyperparathyroidism.

Authors:
Ao Wang Lei Yuan

Clin Case Rep 2019 Apr 5;7(4):849-850. Epub 2019 Mar 5.

Department of Endocrinology, the Second Affiliated Hospital Chongqing Medical University Chongqing China.

We report a case of hyperparathyroidism with hypercalcemia caused by a giant parathyroid adenoma. We use a technetium sestamibi scan to locate parathyroid mass. Bone emission computed tomography revealed the classic signs of metabolic osteopathy. Read More

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http://dx.doi.org/10.1002/ccr3.2035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452475PMC

Parathyroid carcinoma, an unusual cause of primary hyperparathyroidism.

Acta Otorrinolaringol Esp 2019 Apr 14. Epub 2019 Apr 14.

Servicio de Otorrinolaringología, Complexo Hospitalario Universitario A Coruña, A Coruña, España.

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https://linkinghub.elsevier.com/retrieve/pii/S00016519193003
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http://dx.doi.org/10.1016/j.otorri.2018.11.001DOI Listing
April 2019
1 Read

INCREASED MORTALITY IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM: DOES SURGERY MAKE A DIFFERENCE?

Endocr Pract 2019 Apr;25(4):335-339

Primary hyperparathyroidism (PHPT) is functionally characterized by an inappropriately raised secretion of parathyroid hormone, leading to raised serum calcium levels. Some patients are referred for parathyroidectomy, and some are managed conservatively. The aim of the audit was to compare the mortality outcomes between the two groups. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0407
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http://dx.doi.org/10.4158/EP-2018-0407DOI Listing
April 2019
2 Reads

Clinical Features of Multiple Endocrine Neoplasia Type 4 - Novel pathogenic variant and review of published cases.

J Clin Endocrinol Metab 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical Research, Faculty of Health, University of Southern Denmark (SDU).

Context: The clinical phenotype of multiple endocrine neoplasia type 4 (MEN4) is undefined due to a limited number of published cases. Knowledge on disease manifestation in MEN4 is essential for developing prevention programs and treatment.

Objective: To expand current knowledge of the MEN4 phenotype including assessment of penetrance. Read More

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http://dx.doi.org/10.1210/jc.2019-00082DOI Listing
April 2019
1 Read

Ferric Citrate Attenuates Cardiac Hypertrophy and Fibrosis in a Rat Model of Chronic Kidney Disease.

Iran J Kidney Dis 2019 Mar;13(2):98-104

Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, USA.

Introduction: Chronic kidney disease (CKD) promotes hypertrophy and fibrosis in heart, and increases the risk of cardiovascular mortality. Ferric citrate is a dietary phosphate binder used to control hyperphosphatemia in CKD patients. It has been shown to raise iron stores, improve anemia and secondary hyperparathyroidism, and decrease vascular calcification in CKD patients. Read More

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March 2019
1 Read

Diagnosis and treatment of confirmed and suspected primary hyperparathyroidism in equids: 17 cases (1999-2016).

Equine Vet J 2019 Apr 13. Epub 2019 Apr 13.

Baker Institute for Animal Health, Cornell University College of Veterinary Medicine, Ithaca, New York, 14853, USA.

Background: Primary hyperparathyroidism is uncommon in equids.

Objectives: To describe the diagnostic findings and efficacy of treatment in equids with primary hyperparathyroidism.

Study Design: Retrospective case series describing sixteen horses and one mule. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/evj.13120
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http://dx.doi.org/10.1111/evj.13120DOI Listing
April 2019
7 Reads

Deficiency in the secreted protein Semaphorin3d causes abnormal parathyroid development in mice.

J Biol Chem 2019 Apr 12. Epub 2019 Apr 12.

Cardiovascular and Metabolic Disorders Program, Duke NUS Medical School, Singapore.

Primary hyperparathyroidism (PHPT) is a common endocrinopathy characterized by hypercalcemia and elevated levels of parathyroid hormone. The primary cause for PHPT is a benign overgrowth of parathyroid tissue causing excessive secretion of parathyroid hormone. However, the molecular etiology of PHPT is incompletely defined. Read More

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http://dx.doi.org/10.1074/jbc.RA118.007063DOI Listing
April 2019
1 Read

Biological secondary contributors to osteoporosis in fractured patients, is an early systematic assay relevant?

Joint Bone Spine 2019 Apr 9. Epub 2019 Apr 9.

Rheumatology Department, Cochin Hospital, 75014 Paris, France; INSERM U1153, 75014 Paris France. Electronic address:

Objective: To evaluate the prevalence of biological abnormalities leading to secondary osteoporosis in recently fractured patients.

Methods: Adults older than 50, hospitalized for a nonvertebral fracture from July 2015 to October 2016, were assessed for bone fragility contributors in the Orthopedics Department. Bone mineral density (BMD) measurements and Vertebral Fracture assessment (VFA) were performed within 3 months. Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.03.009DOI Listing
April 2019
1 Read

Vitamin D, bone alkaline phosphatase and parathyroid hormone in healthy subjects and haemodialysed patients from West Africa: impact of reference ranges and parathyroid hormone generation assays on the KDIGO guidelines.

Clin Kidney J 2019 Apr 5;12(2):288-293. Epub 2018 Sep 5.

Department of Nephrology, Dialysis and Transplantation, University of Liège, CHU de Liège, Liège, Belgium.

Background: The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend targets based on multiples of the upper limit of normal (ULN) of parathyroid hormone (PTH) concentration. However, the ULN has not always been correctly established by manufacturers. While it is known that the ULN is supposed to be higher in African Americans than in Caucasians, it is largely unknown in Africans. Read More

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https://academic.oup.com/ckj/article/12/2/288/5091022
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http://dx.doi.org/10.1093/ckj/sfy074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452202PMC
April 2019
3 Reads

Novel insights into parathyroid hormone: report of The Parathyroid Day in Chronic Kidney Disease.

Clin Kidney J 2019 Apr 20;12(2):269-280. Epub 2018 Jul 20.

Division of Nephrology, Ambroise Paré University Medical Center, APHP, University of Paris Ouest (UVSQ), Boulogne Billancourt/Paris, France.

Chronic kidney disease (CKD) is often associated with a mineral and bone disorder globally described as CKD-Mineral and Bone Disease (MBD), including renal osteodystrophy, the latter ranging from high bone turnover, as in case of secondary hyperparathyroidism (SHPT), to low bone turnover. The present article summarizes the important subjects that were covered during 'The Parathyroid Day in Chronic Kidney Disease' CME course organized in Paris in September 2017. It includes the latest insights on parathyroid gland growth, parathyroid hormone (PTH) synthesis, secretion and regulation by the calcium-sensing receptor, vitamin D receptor and fibroblast growth factor 23 (FGF23)-Klotho axis, as well as on parathyroid glands imaging. Read More

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http://dx.doi.org/10.1093/ckj/sfy061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452197PMC
April 2019
2 Reads

Intraoperative parathyroid hormone levels ≤40 pg/mL are associated with the lowest persistence rates after parathyroidectomy for primary hyperparathyroidism.

Surgery 2019 Apr 8. Epub 2019 Apr 8.

University of Michigan Medical School, Ann Arbor; Department of Surgery, University of Michigan, Ann Arbor. Electronic address:

Background: Intraoperative parathyroid hormone (IOPTH) monitoring is used to predict biochemical cure during parathyroidectomy for primary hyperparathyroidism; however, there is variability in the intraoperative parathyroid hormone criteria used by surgeons to predict normocalcemia after parathyroidectomy. This study sought to determine the intraoperative parathyroid hormone criteria correlated with the lowest rates of persistent hyperparathyroidism after parathyroidectomy for primary hyperparathyroidism.

Materials And Methods: This is a retrospective cohort study of 2,654 patients with primary hyperparathyroidism who underwent parathyroidectomy with intraoperative parathyroid hormone monitoring at a single institution from 1999 to 2014. Read More

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http://dx.doi.org/10.1016/j.surg.2019.01.024DOI Listing
April 2019
1 Read

Genome-wide analysis of differentially expressed lncRNA in sporadic parathyroid tumors.

Osteoporos Int 2019 Apr 10. Epub 2019 Apr 10.

Department of Medical Genetics and Developmental Biology, Capital Medical University, Beijing, 100069, China.

Diagnosis of parathyroid carcinoma on histological examination is challenging. Thousands of differentially expressed lncRNAs were identified on the microarray data between parathyroid cancer and adenoma samples. Four lncRNAs were significantly dysregulated in further validation. Read More

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http://dx.doi.org/10.1007/s00198-019-04959-yDOI Listing
April 2019
1 Read

25-Hydroxyvitamin D and Vitamin D Binding Protein Levels in Patients With Primary Hyperparathyroidism Before and After Parathyroidectomy.

Front Endocrinol (Lausanne) 2019 27;10:171. Epub 2019 Mar 27.

Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, United States.

To evaluate vitamin D binding protein and free 25-hydroxyvitamin D [25(OH)D] levels in healthy controls compared to primary hyperparathyroidism (PHPT) patients, and to examine PHPT before and after surgery. Seventy-five PHPT patients and 75 healthy age, gender, and body mass index (BMI) -matched control subjects were examined. In addition, 25 PHPT patients underwent parathyroidectomy and had a 3-month follow up visit. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2019.00171
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http://dx.doi.org/10.3389/fendo.2019.00171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446311PMC
March 2019
13 Reads

Bradycardia secondary to primary hyperparathyroidism.

J Int Med Res 2019 Apr 10:300060519841156. Epub 2019 Apr 10.

1 Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.

Clinical doctors rarely associate hyperparathyroidism with significant bradyarrhythmia. We report a rare case of a patient initially misdiagnosed with primary sick sinus syndrome, which was eventually shown to be secondary to primary hyperparathyroidism. Read More

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http://dx.doi.org/10.1177/0300060519841156DOI Listing
April 2019
1 Read

The Key Role of Phosphate on Vascular Calcification.

Toxins (Basel) 2019 Apr 9;11(4). Epub 2019 Apr 9.

Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, S. Orsola Hospital, University of Bologna, 40138 Bologna, Italy.

Vascular calcification (VC) is common in dialysis and non-dialysis chronic kidney disease (CKD) patients, even in the early stage of the disease. For this reason, it can be considered a CKD hallmark. VC contributes to cardiovascular disease (CVD) and increased mortality among CKD patients, although it has not been proven. Read More

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http://dx.doi.org/10.3390/toxins11040213DOI Listing
April 2019
1 Read

Parathyroid Computed Tomography Angiography: Early Experience with a Novel Imaging Technique in Primary Hyperparathyroidism.

Otolaryngol Head Neck Surg 2019 Apr 9:194599819842106. Epub 2019 Apr 9.

4 Department of Radiology, Naval Medical Center San Diego, San Diego, CA.

Objectives: To describe parathyroid computed tomography angiography (PCTA), determine its accuracy, and, as a secondary objective, calculate its mean radiation dosimetry.

Study Design: Retrospective chart review of patients who underwent parathyroidectomy for primary hyperparathyroidism from 2007 to 2015.

Setting: Single-center tertiary care academic military hospital. Read More

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http://dx.doi.org/10.1177/0194599819842106DOI Listing
April 2019
1 Read

Calcium and vitamin D supplementation. Myths and realities with regard to cardiovascular risk.

Curr Vasc Pharmacol 2019 Apr 8. Epub 2019 Apr 8.

Dipartimento di Medicina Clinica e Chirurgia, Endocrinology Unit, Federico II University Medical School of Naples. Italy.

Vitamin D and calcium are considered crucial for the treatment of bone diseases. Both vitamin D and calcium contribute to bone homeostasis but also preserve muscle health by reducing the risk of falls and fractures. Low vitamin D concentrations result in secondary hyperparathyroidism and contribute to bone loss, although the development of secondary hyperparathyroidism varies, even in patients with severe vitamin D deficiency. Read More

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http://dx.doi.org/10.2174/1570161117666190408165805DOI Listing
April 2019
3 Reads

Orthopedics in Reptiles and Amphibians.

Vet Clin North Am Exot Anim Pract 2019 May;22(2):285-300

Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, 2065 West Farm Road, Stillwater, OK 74078, USA.

Musculoskeletal disorders are a common cause for presentation of reptiles and amphibians to the veterinarian. A clinical approach to orthopedic cases starts with a thorough history and review of husbandry, and identification of any underlying or concomitant disease. Medical management is indicated for pathologic fractures. Read More

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http://dx.doi.org/10.1016/j.cvex.2019.01.009DOI Listing
May 2019
1 Read

The effect of parathyroidectomy on patients' symptoms in tertiary hyperparathyroidism.

Head Neck 2019 Apr 7. Epub 2019 Apr 7.

Singhealth Duke-NUS Head & Neck Centre, Singapore, Singapore.

Background: The efficacy of parathyroidectomy for primary and secondary hyperparathyroidism is well-established but evidence in tertiary hyperparathyroidism is lacking. We examined parathyroidectomy's effect in tertiary hyperparathyroidism.

Methods: Patients with tertiary hyperparathyroidism who underwent parathyroidectomy were followed up for 12 months. Read More

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http://dx.doi.org/10.1002/hed.25750DOI Listing
April 2019
7 Reads

Complications Encountered with Non-adherence to Regular Follow-up in the Long-term Medical Management of Hyperparathyroidism.

Cureus 2019 Jan 26;11(1):e3966. Epub 2019 Jan 26.

Internal Medicine, Louis Stokes Cleveland VA Medical Center, Cleveland, USA.

Primary hyperparathyroidism is the third most commonly encountered endocrine disorder after diabetes and thyroid diseases. There has been a constant debate between medical and surgical management of the disorder. Guidelines clearly indicate surgical management over medical management in symptomatic patients and asymptomatic patients below 50 years of age. Read More

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http://dx.doi.org/10.7759/cureus.3966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436886PMC
January 2019
1 Read

Primary Hyperparathyroidism in Pregnancy: A Multicenter Case Series of 4 Patients from Northern India.

J Obstet Gynaecol India 2019 Apr 5;69(Suppl 1):31-35. Epub 2018 Jul 5.

7Department of Gastroenterology, Fortis Escorts Hospital, Jaipur, Rajasthan India.

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http://dx.doi.org/10.1007/s13224-018-1148-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431693PMC
April 2019
1 Read

Efficacy and safety of evocalcet in Japanese peritoneal dialysis patients.

Clin Exp Nephrol 2019 Apr 6. Epub 2019 Apr 6.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Namics 301, 4-24-51 Takanawa, Minato-ku, Tokyo, 108-0074, Japan.

Background: Secondary hyperparathyroidism (SHPT) is a serious and common complication in patients receiving peritoneal dialysis (PD). Cinacalcet is currently the recommended therapy for SHPT; however, gastrointestinal (GI)-related symptoms can result in low adherence and high discontinuation rates. Evocalcet is a novel calcimimetic agent that has non-inferior efficacy while providing a more tolerable safety profile. Read More

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http://link.springer.com/10.1007/s10157-019-01692-y
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http://dx.doi.org/10.1007/s10157-019-01692-yDOI Listing
April 2019
3 Reads

Mild sporadic primary hyperparathyroidism: high rate of multiglandular disease is associated with lower surgical cure rate.

Langenbecks Arch Surg 2019 Apr 6. Epub 2019 Apr 6.

Service de Médecine Nucléaire, CHU de Nantes, Hôtel Dieu, Paris, France.

Background: Mild primary hyperparathyroidism (serum calcium ≤ 2.85 mmol/L) is the most representative form of pHPT nowadays. The aim of this study was to evaluate its subtypes and the multiglandular disease (MGD) rate as it may lower the sensitivity of preoperative parathyroid scintigraphy and the surgical cure rate. Read More

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http://dx.doi.org/10.1007/s00423-019-01782-1DOI Listing
April 2019
2 Reads

Corrigendum to "Effects of parathyroidectomy on the biology of bone tissue in patients with chronic kidney disease and secondary hyperparathyroidism" [Bone 121 (April 2019) 277-283].

Bone 2019 Apr 4;123:189-190. Epub 2019 Apr 4.

LIM 16 - Laboratorio de Fisiopatologia Renal, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Hospital Samaritano Americas Serviços Medicos, Sao Paulo, SP, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2019.03.030DOI Listing
April 2019
1 Read

Parkinsonism as presenting symptom of primary hyperparathyroidism: Improvement after surgery.

Cir Cir 2019 ;86(1):96-98

Department of General and Digestive System Surgery, Hospital General Universitario Reina Sofía, Murcia, Spain.

Introduction: Hypercalcemia can cause different neurological disorders, depending on the calcium level. We report an exceptional case of primary hyperparathyroidism presenting as neurological alteration and it has favourable outcome after parathyroidectomy.

Case Report: A 74-year-old woman presented with progressive cognitive deterioration and impaired motor function. Read More

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http://dx.doi.org/10.24875/CIRUE.M18000015DOI Listing
January 2019
1 Read

Acute neurological syndrome complicating secondary hyperparathyroidism.

Proc (Bayl Univ Med Cent) 2018 Oct 24;31(4):534-536. Epub 2018 Sep 24.

Division of Nephrology, Department of Internal Medicine, Baylor University Medical CenterDallasTexas.

Longstanding severe hyperparathyroidism can lead to the formation of "brown tumors," benign but locally aggressive neoplasms. We present the case of a young woman with end-stage renal disease on hemodialysis with uncontrolled secondary hyperparathyroidism. The patient presented with progressive lower extremity weakness and back pain. Read More

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https://www.tandfonline.com/doi/full/10.1080/08998280.2018.1
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http://dx.doi.org/10.1080/08998280.2018.1499004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413995PMC
October 2018
5 Reads

Management of brown tumor of spine with primary hyperparathyroidism: A case report and literature review.

Medicine (Baltimore) 2019 Apr;98(14):e15007

Spinal tumor center, Department of Orthopaedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Rationale: Brown tumor (BT) is a rare benign lesion in skeletal system. It is especially rare secondary to primary hyperparathyroidism (HPT). The differential diagnosis can be misleading due to its diversified clinical characteristics. Read More

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http://dx.doi.org/10.1097/MD.0000000000015007DOI Listing
April 2019
3 Reads

Intraoperative verification of parathyroid glands in primary and secondary hyperparathyroidism using near-infrared autofluorescence (IOPA).

Updates Surg 2019 Apr 3. Epub 2019 Apr 3.

Schwarzwald-Baar Klinikum Villingen-Schwenningen, Klinikstrasse 11, Villingen-Schwenningen, 78052, Germany.

Intraoperative verification of parathyroid glands relies on visual identification by the surgeon and, with some time delay, on serum parathormon measurements and frozen section. Fluorescence imaging, however, is an instant on-table method for direct visualization of parathyroid tissue which is known to exhibit increased autofluorescence intensity when exposed to near-infrared light. In this retrospective observational study, we evaluate the clinical use of this method in a series of patients with primary and secondary hyperparathyroidism. Read More

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http://dx.doi.org/10.1007/s13304-019-00652-1DOI Listing
April 2019
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Reference range of random urinary calcium creatinine ratio in North Indian children and adolescents.

Ann Pediatr Endocrinol Metab 2019 Mar 31;24(1):34-40. Epub 2019 Mar 31.

Central Council of Homeopathic Research, New Delhi, India.

Purpose: Urinary calcium creatinine ratio (UCaCrR) is a reliable indicator for monitoring hypercalciuria following vitamin D supplementation. However, the reference range varies from region to region. Previous studies did not take vitamin D and parathyroid hormone status into account while evaluating UCaCrR. Read More

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http://e-apem.org/journal/view.php?doi=10.6065/apem.2019.24.
Publisher Site
http://dx.doi.org/10.6065/apem.2019.24.1.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449613PMC
March 2019
5 Reads

Refractory secondary hyperparathyroidism in waiting list for parathyroidectomy: who we should operate first in a quaternary hospital in Brazil regarding survival.

Ren Fail 2019 Nov;41(1):183-189

b Rio de Janeiro State University, Medical Sciences Post-Graduation Program , Rio de Janeiro , Brazil.

Background: Few centers in Brazil perform parathyroidectomy (PTX) for recalcitrant secondary hyperparathyroidism (SHPT) generating a long queue. There is little data regarding prioritize criteria besides chronological order and survival.

Objectives: To determine the difference of clinical and laboratory factors between PTX patients and those who remained in the line despite the need for surgery and their survival. Read More

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http://dx.doi.org/10.1080/0886022X.2019.1590210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450528PMC
November 2019
1 Read

Doughnut Shaped Parathyroid Adenoma

Mol Imaging Radionucl Ther 2019 Mar;28(1):41-43

University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Pathology, Ankara, Turkey

A 52-year-old woman presented with a complaint of neck swelling. The patient showed signs of hyperparathyroidism: hypercalcemia, and hypophosphatemia. Tc-99m MIBI dual-phase parathyroid scintigraphy and SPECT revealed increased activity in a regular-bordered, “doughnut”-shaped mass on the left side of the thyroid gland with a central hypoactive area. Read More

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http://dx.doi.org/10.4274/mirt.galenos.2018.06977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455100PMC
March 2019
8 Reads

Phenprocoumon based anticoagulation is an underestimated factor in the pathogenesis of calciphylaxis.

BMC Nephrol 2019 Apr 2;20(1):114. Epub 2019 Apr 2.

Department of Nephrology, University Hospital of Marburg, UKGM GmbH, Baldingerstraße 1, 35033, Marburg, Germany.

Background: Calciphylaxis is a life threatening complication in renal patients. Of great importance is the identification of concomitant factors for calciphylaxis. Due to the variability of clinical presentation the evaluation of such factors may be obscured when calciphylaxis diagnosis is based just on clinical features. Read More

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http://dx.doi.org/10.1186/s12882-019-1301-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444830PMC
April 2019
4 Reads