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    Association of Hypercalcemia Before Treatment With Hypocalcemia After Treated in Dogs With Primary Hyperparathyroidism.
    J Vet Intern Med 2017 Feb 18. Epub 2017 Feb 18.
    Department of Medicine and Epidemiology, University of California, Davis, CA.
    Background: Development of hypocalcemia after treatment of hyperparathyroidism results in increased costs and risk of poorer outcomes. Previous studies have shown conflicting data about predictors of hypocalcemia after these procedures.

    Hypothesis/objectives: The objective of this study was to investigate whether ionized calcium (iCa) concentrations before treatment are predictive of hypocalcemia or its clinical signs after surgical removal or heat ablation in dogs with primary hyperparathyroidism. Read More

    Parathyroid hormone in renal transplanted recipients; a single center study.
    J Nephropharmacol 2013 1;2(1):3-4. Epub 2013 Jan 1.
    Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
    This investigation, aimed to study of intact parathormone (iPTH) and calcium (Ca) in a group of kidney transplanted patients and also we aimed to test the relationship of iPTH with various demographic data of kidney transplanted recipients. We studied 72 kidney transplanted persons with mean ages of 44±12 years. In this study, mean iPTH was 18. Read More

    Surgical management of a giant parathyroid adenoma through minimal invasive parathyroidectomy. A case report.
    Int J Surg Case Rep 2017 Jan 31;31:262-265. Epub 2017 Jan 31.
    1st Department of Surgery, 401 Army General Hospital of Athens, Greece.
    Introduction: Primary hyperparathyroidism is a common endocrine disorder mostly associated to parathyroid adenomas. Although those tend to be small in size, rare cases of giant parathyroid adenomas may be present.

    Case Presentation: A 42year old female was admitted in our department due to weakness and vague abdominal pain for the past 8 months. Read More

    Atypical parathyroid adenoma.
    Indian J Pathol Microbiol 2017 Jan-Mar;60(1):99-101
    Department of Pathology, P.E.S. Institute of Medical Sciences and Research, Kuppam, Andhra Pradesh, India.
    Parathyroid lesions clinically manifest themselves in the form of primary hyperparathyroidism most of the times. Parathyroid adenoma constitutes one of the important causes of the same. Although rare, they pose considerable diagnostic dilemma to the pathologist. Read More

    Feasibility and safety of minimally invasive radioguided parathyroidectomy using very low intraoperative dose of Tc-99m MIBI.
    Int J Surg 2017 Feb 10;39:229-233. Epub 2017 Feb 10.
    Surgical Oncology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
    Background: Surgical resection of the abnormal parathyroid glands is the only curative treatment for primary hyperparathyroidism (PHPT). Radioguided parathyroidectomy with technetium-99m (TC-99m) sestamibi has been successfully used in patients with PHPT. This study was designed to evaluate the results of a series of patients with PHPT who underwent minimally invasive radioguided parathyroidectomy (MIRP) using very low dose (1 mCi) of TC-99m sestamibi (MIBI) without application of intraoperative parathyroid hormone (PTH) assay or frozen section analysis. Read More

    Diagnostic performance of computed tomography for parathyroid adenoma localization; a systematic review and meta-analysis.
    Eur J Radiol 2017 Mar 5;88:117-128. Epub 2017 Jan 5.
    Department of Surgery, University of California San Francisco, United States.
    Purpose: To perform a systematic review and meta-analysis of the sensitivity and positive predictive value (PPV) of CT for preoperative parathyroid localization in patients with primary hyperparathyroidism (pHPT), and subsequently compare the different protocols and their performance in different patient groups.

    Materials And Methods: We performed a search of the Embase, Pubmed and Cochrane Library databases to identify studies published between January 1, 2000 and March 31, 2016 investigating the diagnostic value of CT for parathyroid localization in patients with biochemical diagnosis of pHPT. Performance of CT was expressed in sensitivity and PPV with pooled proportion using a random-effects model. Read More

    Association of Vitamin D Metabolites with Parathyroid Hormone, Fibroblast Growth Factor-23, Calcium, and Phosphorus in Dogs with Various Stages of Chronic Kidney Disease.
    J Vet Intern Med 2017 Feb 10. Epub 2017 Feb 10.
    Veterinary Clinical Sciences, The Ohio State University, Columbus, OH.
    Background: Hypovitaminosis D is associated with progression of renal disease, development of renal secondary hyperparathyroidism (RHPT), chronic kidney disease-mineral bone disorder (CKD-MBD), and increased mortality in people with CKD. Despite what is known regarding vitamin D dysregulation in humans with CKD, little is known about vitamin D metabolism in dogs with CKD.

    Objectives: The purpose of our study was to further elucidate vitamin D status in dogs with different stages of CKD and to relate it to factors that affect the development of CKD-MBD, including parathyroid hormone (PTH), fibroblast growth factor-23 (FGF-23), calcium, and phosphorus concentrations. Read More

    [Clinical features and mutations of RET proto-oncogene in a pedigree affected with type 2A multiple endocrine neoplasia].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2017 Feb;34(1):106-109
    Department of Endocrinology and Metabolism, Huai'an Second People's Hospital, Huai'an, Jiangsu 223002, China.
    Objective: To investigate the clinical features and mutations of RET proto-oncogene in a pedigree affected with multiple endocrine neoplasia type 2A (MEN2A).

    Methods: Clinical data of the family members was collected. Genomic DNA from peripheral blood leukocytes were extracted and subjected to PCR amplification. Read More

    Why Current PTH Assays Mislead Clinical Decision Making in Patients with Secondary Hyperparathyroidism.
    Nephron 2017 02 10. Epub 2017 Feb 10.
    Institute of Nutritional Science, University of Potsdam, Potsdam, Germany.
    Preclinical studies in cell culture systems as well as in whole animal chronic kidney disease (CKD) models showed that parathyroid hormone (PTH), oxidized at the 2 methionine residues (positions 8 and 18), caused a loss of function. This was so far not considered in the development of PTH assays used in current clinical practice. Patients with advanced CKD are subject to oxidative stress, and plasma proteins (including PTH) are targets for oxidants. Read More

    Stepwise CaSR, AP2S1, and GNA11 sequencing in patients with suspected familial hypocalciuric hypercalcemia.
    Endocrine 2017 Feb 7. Epub 2017 Feb 7.
    Department of Genetics and Metabolic diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
    Purpose: Patients with familial hyperparathyroidism and low urinary calcium excretion may have familial hypocalciuric hypercalcemia (FHH) with mutations in one of three genes: the calcium-sensing receptor (CaSR) defining FHH-type 1, the adaptor-related protein complex 2 (AP2S1) related to FHH-type 3 or the G-protein subunit alpha11 (GNA11) associated with FHH-type 2. We aimed to evaluate the presence of mutations in these genes and to identify phenotypic specificities and differences in these patients.

    Subjects And Methods: Selected patients were recruited for genetic evaluation. Read More

    Skeletal effects of vitamin D deficiency among patients with primary hyperparathyroidism.
    Osteoporos Int 2017 Feb 7. Epub 2017 Feb 7.
    Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, South Korea.
    Little is known about the association between vitamin D deficiency and the skeletal phenotypes in primary hyperparathyroidism (PHPT) patients. A low 25-hydroxyvitamin D level was associated with a low bone mineral density and deteriorated hip geometry in women with PHPT in an Asian population where vitamin D deficiency is prevalent.

    Introduction: Few studies have examined the effect of vitamin D deficiency on the bone health of primary hyperparathyroidism (PHPT) patients. Read More

    Influence of Parathyroidectomy on Bone Calcium Concentration: Evaluation with Spectral CT in Patients with Secondary Hyperparathyroidism Undergoing Hemodialysis-A Prospective Feasibility Study.
    Radiology 2017 Feb 7:161797. Epub 2017 Feb 7.
    From the Departments of Radiology (Q.M., Z.Y.) and Nephrology (X.H.), Beijing Friendship Hospital, Capital Medical University, 95 YongAn Road, Beijing, 100050, P.R. China; Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, P.R. China (F.L.); Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, P.R. China (D.S.); and Department of Radiology, Beijing Puren Hospital Affiliated to Capital Medical University, P.R. China (H.X.).
    Purpose To use spectral computed tomography (CT) to evaluate the influence of parathyroidectomy (PTX) on calcium concentration in trabecular bone and cortical bone in patients undergoing hemodialysis with secondary hyperparathyroidism. Materials and Methods This study was performed with institutional review board approval. Written consent was obtained from each patient. Read More

    Validation of selective use of intraoperative PTH monitoring in parathyroidectomy.
    J Otolaryngol Head Neck Surg 2017 Feb 6;46(1):10. Epub 2017 Feb 6.
    Department of Otolaryngology-Head and Neck Surgery, University of Manitoba, Winnipeg, Manitoba, Canada.
    Background: The objective of this study was to validate our approach of treating primary hyperparathyroidism using sestamibi scan directed parathyroidectomy, without routine use of intraoperative parathyroid hormone measurements (ioPTH).

    Methods: We prospectively established a protocol limiting the use of ioPTH to patients with negative or equivocal sestamibi scans, and those who had risk factors for multi-gland disease. We then performed a retrospective review to determine our disease control rate. Read More

    Epigenetic Alterations in Parathyroid Cancers.
    Int J Mol Sci 2017 Feb 1;18(2). Epub 2017 Feb 1.
    Endocrinology Unit, Department of Biomedical Sciences for Health, University of Milan, IRCCS Istituto Ortopedico Galeazzi, 20097 Milan, Italy.
    Parathyroid cancers (PCas) are rare malignancies representing approximately 0.005% of all cancers. PCas are a rare cause of primary hyperparathyroidism, which is the third most common endocrine disease, mainly related to parathyroid benign tumors. Read More

    Scan-directed mini-incision focused parathyroidectomy: how accurate is accurate enough?
    Ann R Coll Surg Engl 2017 Feb;99(2):123-128
    Department of General Surgery, East Lancashire Hospitals NHS Trust, Royal Blackburn Hospital , Blackburn , UK.
    INTRODUCTION Mini-incision focused parathyroidectomy (MI-FP) is advocated as an alternative to bilateral neck exploration (BNE), owing to its reduced morbidity. The site and side of the affected gland is identified preoperatively using a combination of ultrasound and sestamibi scans. However, the acceptable degree of inter-scan concordance required to prompt MI-FP without compromising accuracy is undetermined. Read More

    Critical Hand Ischemia After Radial Access for Coronary Angiography - Case Report.
    Pol J Radiol 2017 12;82:19-23. Epub 2017 Jan 12.
    Department of Diagnostic and Interventional Radiology, Central Clinical Hospital of the Ministry of Internal Affairs, Warsaw, Poland; Department of Diagnostic and Interventional Radiology, Medical Centre for Postgraduate Education, Warsaw, Poland.
    Background: Radial artery is now the most frequent access for coronary angiography and intervention. Despite the common opinion that it is safer than femoral access, it has the potential for serious complications. One of them is upper limb ischemia caused by radial artery thrombosis. Read More

    [Role of fibroblast growth factor 23 in the development of cardiovascular diseases in patients with end-stage renal failure on programmed hemodialysis].
    Ter Arkh 2016 ;88(12):51-56
    North Ossetian State Medical Academy, Ministry of Health of Russia, Vladikavkaz, Russia.
    Aim: To determine the nature of changes in fibroblast growth factor 23 (FGF-23) and other bone mineral metabolism parameters detectable in the blood of patients with end-stage chronic renal failure (CRF) and to analyze their links to the development of cardiovascular events in uremic intoxication.

    Subjects And Methods: A total of 75 patients (45 men and 30 women) aged 23 to 66 years (mean age, 53±2.1 years) with Stage VD CKF were examined. Read More

    Preoperative Localization of Mediastinal Parathyroid Adenoma with Intra-arterial Methylene Blue.
    Cardiovasc Intervent Radiol 2017 Jan 30. Epub 2017 Jan 30.
    Department of Diagnostic Radiology, American University of Beirut Medical Center, Beirut, Lebanon.
    Ectopic parathyroid is found in 16% of patients with hyperparathyroidism. 2% of ectopic parathyroid adenomas are not accessible to standard cervical excision. In such cases, video-assisted thoracoscopic resection is the recommended definitive treatment. Read More

    [Nephrolithiasis associated with normocalcemic or hypercalcemic primary hyperparathyroidism: focus on calciomimetics].
    G Ital Nefrol 2016 Nov-Dec;33(6)
    Primary hyperparathyroidism (PHPT) is a disease involving a broad range of alterations of calcium homeostasis, sustained by parathyroid hormone (PTH) levels that are clearly abnormal. The anomalies directly associated with hyperparathyroidism are nephrolithiasis and fibrocystic bone disease. Since PHPT resolves when abnormal parathyroid tissue is removed, surgery is clearly the only definitive approach to this type of hyperparathyroidism. Read More

    [Multiple Endocrine Neoplasia Type 1(MEN1)Presenting with Hypoglycemic Attacks - A Case Report].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2196-2198
    Dept. of Surgery, Kobe Ekisaikai Hospital.
    A woman in her 60s visited our hospital because of frequent hypoglycemia and episodes of unconsciousness over the last 6 years. A 4 cm tumor was detected on the pancreatic tail using abdominal computed tomography and ultrasonography. An insulinoma was strongly suspected from the results of the fasting test and glucagon load test, and a distal pancreatectomy with splenectomy was performed. Read More

    Multiple endocrine neoplasia syndrome type 1: institution, management, and data analysis of a nationwide multicenter patient database.
    Endocrine 2017 Jan 28. Epub 2017 Jan 28.
    Department of Surgery and Translational Medicine, University of Florence, Largo Palagi 1, 50139, Florence, Italy.
    Objective: The aim of this study was to integrate European epidemiological data on patients with multiple endocrine neoplasia type 1 by creating an Italian registry of this syndrome, including clinical and genetic characteristics and therapeutic management.

    Methods: Clinical, familial and genetic data of patients with multiple endocrine neoplasia type 1, diagnosed, treated, and followed-up for a mean time of 11.3 years, in 14 Italian referral endocrinological centers, were collected, over a 3-year course (2011-2013), to build a national electronic database. Read More

    Primary Hyperparathyroidism: Effects on Bone Health.
    Endocrinol Metab Clin North Am 2017 Mar 14;46(1):87-104. Epub 2016 Dec 14.
    Section of Endocrine Surgery, UCLA David Geffen School of Medicine, 10833 Le Conte Avenue, 72-250 CHS, Los Angeles, CA 90095, USA. Electronic address:
    Primary hyperparathyroidism (PHPT) is the most common cause of chronic hypercalcemia. With the advent of routine calcium screening, the classic presentation of renal and osseous symptoms has been largely replaced with mild, asymptomatic disease. In hypercalcemia caused by PHPT, serum parathyroid hormone levels are either high, or inappropriately normal. Read More

    Diseases associated with calcium-sensing receptor.
    Orphanet J Rare Dis 2017 Jan 25;12(1):19. Epub 2017 Jan 25.
    Service d'Endocrinologie et Métabolisme, Hôpital C Huriez Centre Hospitalo-universitaire de Lille, 1 rue Polonovski, 59 037, Lille Cedex, France.
    The calcium-sensing receptor (CaSR) plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary calcium excretion. The diseases caused by an abnormality of the CaSR are genetically determined or are more rarely acquired. The genetic diseases consist of hyper- or hypocalcemia disorders. Read More

    (18)F Fluorocholine PET/MR Imaging in Patients with Primary Hyperparathyroidism and Inconclusive Conventional Imaging: A Prospective Pilot Study.
    Radiology 2017 Jan 25:160768. Epub 2017 Jan 25.
    From the Departments of Surgery (W.P.K., J.E.G., W.T.S., Q.Y.D., I.S.) and Radiology and Nuclear Medicine (T.A.H., C.M.G., M.H.P.), University of California San Francisco, UCSF Mount Zion, 1600 Divisadero St, Hellman Building Room C347, San Francisco, CA 94115; Departments of Surgery (W.P.K., M.R.V.) and Radiology and Nuclear Medicine (B.d.K.), University Medical Center Utrecht, Utrecht, the Netherlands; and Department of Surgery, University Health Network, Toronto, Ont, Canada (J.D.P.).
    Purpose To investigate the performance of flourine 18 ((18)F) fluorocholine (FCH) positron emission tomography (PET)/magnetic resonance (MR) imaging in patients with hyperparathyroidism and nonlocalized disease who have negative or inconclusive results at ultrasonography (US) and technetium 99m ((99m)Tc) sestamibi scintigraphy. Materials and Methods This study was approved by the institutional review board. Between May and December 2015, 10 patients (mean age, 70. Read More

    Dynamic Optical Contrast Imaging.
    Otolaryngol Head Neck Surg 2017 Jan 1:194599816686294. Epub 2017 Jan 1.
    1 Department of Head and Neck Surgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
    The variable location and indistinct features of parathyroid glands can make their intraoperative identification challenging. Currently, there exists no routine use of localization methods during surgery. Dynamic optical contrast imaging (DOCI) leverages a novel realization of temporally dependent measurements of tissue autofluorescence that allows the acquisition of specific tissue properties. Read More

    Is Unilateral Neck Surgery Feasible in Patients with Sporadic Primary Hyperparathyroidism and Double Negative Localisation?
    World J Surg 2017 Jan 23. Epub 2017 Jan 23.
    Department of Endocrine Surgery, C2 Office, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK.
    Introduction: Ultrasound and Tc99mMIBI scans are used to localise parathyroid tumours in sporadic primary hyperparathyroidism (pHPT). Intra-operative PTH (ioPTH) assay facilitates unilateral neck exploration (UNE). When both ultrasound and MIBI are negative, it is our policy to explore the left side of the neck and only proceed to bilateral neck exploration (BNE) when either a tumour is not found or when ioPTH does not fall to >50% of the highest pre-excision value. Read More

    Factors Influencing Serum-Hydroxivitamin D Levels and Other Bone Metabolism Parameters in Healthy Older Women.
    J Nutr Health Aging 2017 ;21(2):131-135
    Nicola Veronese, Department of Medicine - DIMED, Geriatrics Division, University of Padova, Padova, Italy, Via Giustiniani 2, 35128 Padova, Italy, Phone: +390498218492; Fax: +390498211218, Email:
    Objective: Older women have frequently low serum 25-hydroxivitamin D (25[OH]D) concentrations, high parathormone (PTH) levels and low bone mineral density (BMD) values. Endogenous synthesis, dietary habits, sunlight exposure and fat-mass-mediated storage may influence 25(OH)D levels and bone metabolism, but the relevance of these factors in the elderly has yet to be fully elucidated. We aimed to investigate the influence of dietary vitamin D intake and fat mass on serum 25(OH)D levels and bone metabolism in older women. Read More

    An Overview of Autosomal Dominant Tumour Syndromes with Prominent Features in the Oral and Maxillofacial Region.
    Head Neck Pathol 2017 Jan 21. Epub 2017 Jan 21.
    Department of Histopathology, King's College Hospital, London, SE5 9R, UK.
    Several autosomal dominant inherited tumour syndromes demonstrate prominent features in the oral and maxillofacial region. Although multiple organ systems are frequently involved, the target organs more frequently affected are the skin (nevoid basal cell carcinoma syndrome, Brooke-Spiegler syndrome, Birt-Hogg-Dube syndrome and Muir-Torre syndrome), gastrointestinal tract (Peutz-Jegher syndrome and Gardner syndrome) or endocrine system (multiple endocrine neoplasia type 2b and hyperparathyroidism-jaw tumour syndrome). In some syndromes, the disease is multisystem with skin index lesions presenting in the head and neck (Cowden syndrome and tuberous sclerosis complex). Read More

    Predictors of operative failure in parathyroidectomy for primary hyperparathyroidism.
    Am J Surg 2017 Jan 10. Epub 2017 Jan 10.
    Department of Surgery, University of Michigan Medical School, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA. Electronic address:
    Introduction: Many adjuncts guide surgical decision making in parathyroidectomy, yet their independent associations with outcome are poorly characterized. We examined a broad range of perioperative factors and used multivariate techniques to identify independent predictors of operative failure (persistent disease) after parathyroidectomy.

    Methods: This was a retrospective review of 2239 patients with primary hyperparathyroidism who underwent parathyroidectomy at a single-center from 1999 to 2014. Read More

    The utility of repeat sestamibi scans in patients with primary hyperparathyroidism after an initial negative scan.
    Surgery 2017 Jan 17. Epub 2017 Jan 17.
    Department of Endocrine Surgery, The Cleveland Clinic, Cleveland, OH.
    Background: We analyzed the utility of repeated sestambi scans in patients with primary hyperparathyroidism and its effects on operative referral.

    Methods: We carried out a retrospective review of patients with primary hyperparathyroidism who underwent repeated sestambi scans exclusively within our health system between 1996-2015. Patient demographic, presentation, laboratory, imaging, operative, and pathologic data were reviewed. Read More

    Effects of the Administration of 25(OH) Vitamin D3 in an Experimental Model of Chronic Kidney Disease in Animals Null for 1-Alpha-Hydroxylase.
    PLoS One 2017 20;12(1):e0170654. Epub 2017 Jan 20.
    Vascular and Renal Translational Research Group, REDinREN del ISCIII, IRBLleida, University Hospital Arnau de Vilanova, Lleida, Spain.
    The final step in vitamin D activation is catalyzed by 1-alpha-hydroxylase (CYP27B1). Chronic kidney disease (CKD) is characterized by low levels of both 25(OH)D3 and 1,25(OH)2D3 provoking secondary hyperparathyroidism (2HPT). Therefore, treatments with active or native vitamin D compounds are common in CKD to restore 25(OH)D3 levels and also to decrease PTH. Read More

    Enlarged parathyroid glands with variable sonomorphology in a case of tertiary hyperparathyroidism: Sonographic-histopathologic correlation.
    Indian J Radiol Imaging 2016 Oct-Dec;26(4):513-516
    Department of Radiology, TNMC and BYL Nair Hospital, Mumbai, Maharashtra, India.
    The typical sonomorphology of homogeneously hypoechoic texture of an enlarged parathyroid gland (PG) is a reflection of uniform arrangement of the parathormone-producing chief cells. A variable cellular arrangement, hemorrhage, fibrosis, and adipocytes cause heterogeneous appearance. We describe a case of a 32-year-old male, a case of tertiary hyperparathyroidism, with increased serum parathormone levels, hypercalcemia, and enlargement of all four PGs, albeit with differing morphology. Read More

    Incidence and Risk Factors of Persistent Hyperparathyroidism After Kidney Transplantation.
    Transplant Proc 2017 Jan - Feb;49(1):53-56
    Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, Japan. Electronic address:
    Persistent hyperparathyroidism after kidney transplantation is related to graft function, but pre-transplantation risk factors of persistent hyperparathyroidism have not been evaluated in detail. We enrolled 86 patients who had undergone kidney transplantation between 2008 and 2014. Nine patients showed persistent hyperparathyroidism characterized by the following: 1) serum parathyroid hormone levels >65 pg/mL and serum calcium levels >10. Read More

    [A Case of Primary Hyperparathyroidism Complicated with Hypercalcemic Crisis during Treatment with Cinacalcet and Improved by Active Treatment].
    Hinyokika Kiyo 2016 Dec;62(12):633-637
    The Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences.
    A 77-year-old man was referred to our department for surgical treatment of a right ureteral stone identified on computed tomography (CT) during intensive examination for spondylolisthesis of L4-L5. At the initial visit, performance status was 4, and renal dysfunction was identified (Cr 1.3 mg/dl). Read More

    Significance of the ionized calcium measurement to assess calcium status in osteopenic/osteoporosis postmenopausal outpatients.
    Gynecol Endocrinol 2017 Jan 19:1-6. Epub 2017 Jan 19.
    b Fondazione CNR-Regione Toscana G Monasterio , Pisa , Italy.
    Introduction: Evaluation of calcium status is important in the osteoporotic risk assessment. Although guidelines indicate total calcium (tCa) as first-line measurement, directly measured ionized calcium (m-iCa), considered as the gold standard, is more and more often required. Aim of this study is to evaluate the agreement between m-iCa, tCa and iCa calculated from a formula based on total calcium and albumin (c-iCa) in osteopenic/osteoporotic postmenopausal outpatients. Read More

    Denosumab for the treatment of bisphosphonate resistant hypercalcemia in a hemodialysis patient.
    Saudi J Kidney Dis Transpl 2017 Jan-Feb;28(1):154-157
    Department of Nephrology and Dialysis, Hospital Louis Jaillon, Saint-Claude, France.
    The acronym of malignancy, iatrogenic, intoxication and immobilization, sarcoidosis, hyperparathyroidism and hyperthyroidism, milk-alkali syndrome, and paget is very helpful in diagnosing hypercalcemia. We report on a 94-year-old patient with history of end-stage renal failure secondary to benign nephroangiosclerosis, who was on maintenance hemodialysis during dialysis, his blood chemistry revealed mild hypercalcemia (2.66 mmol/L) with normal level of intact primary hyperparathyroidism (32. Read More

    Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial.
    JAMA 2017 01;317(2):156-164
    Stanford University, Stanford, California.
    Importance: Secondary hyperparathyroidism contributes to extraskeletal calcification and is associated with all-cause and cardiovascular mortality. Control is suboptimal in the majority of patients receiving hemodialysis. An intravenously (IV) administered calcimimetic could improve adherence and reduce adverse gastrointestinal effects. Read More

    Effect of Etelcalcetide vs Placebo on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: Two Randomized Clinical Trials.
    JAMA 2017 01;317(2):146-155
    Stanford University, Stanford, California.
    Importance: Secondary hyperparathyroidism contributes to extraskeletal complications in chronic kidney disease.

    Objective: To evaluate the effect of the intravenous calcimimetic etelcalcetide on serum parathyroid hormone (PTH) concentrations in patients receiving hemodialysis.

    Design, Setting, And Participants: Two parallel, phase 3, randomized, placebo-controlled treatment trials were conducted in 1023 patients receiving hemodialysis with moderate to severe secondary hyperparathyroidism. Read More

    A novel SLC12A1 gene mutation associated with hyperparathyroidism, hypercalcemia, nephrogenic diabetes insipidus, and nephrocalcinosis in four patients.
    Bone 2017 Jan 14;97:121-125. Epub 2017 Jan 14.
    Center for Endocrinology, Diabetes and Metabolism, Division of Endocrinology, Children's Hospital Los Angeles, Los Angeles, CA, United States; Keck School of Medicine of University of Southern California, Los Angeles, CA, United States. Electronic address:
    Solute Carrier Family 12 member 1 (SLC12A1) gene encodes the sodium-potassium-chloride co-transporter (NKCC2) at the apical membrane of the thick ascending loop of Henle (TAL). Bartter's syndrome (BS) type I is a rare, autosomal recessive, renal tubular disorder associated with mutation of the SLC12A1 gene. Presenting features include: hypokalemic metabolic alkalosis, hypercalciuria and nephrocalcinosis. Read More

    Persistent fibroblast growth factor 23 signalling in the parathyroid glands for secondary hyperparathyroidism in mice with chronic kidney disease.
    Sci Rep 2017 Jan 17;7:40534. Epub 2017 Jan 17.
    Department of Molecular Cell Biology and Molecular Medicine, Institute of Advanced Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan.
    Secondary hyperparathyroidism, in which parathyroid hormone (PTH) is excessively secreted in response to factors such as hyperphosphataemia, hypocalcaemia, and low 1,25-dihydroxyvitamin D (1,25(OH)2D) levels, is commonly observed in patients with chronic kidney disease (CKD), and is accompanied by high levels of fibroblast growth factor 23 (FGF23). However, the effect of FGF23 on the parathyroid glands (PG) remains controversial. To bind to FGF receptors, FGF23 requires αKlotho, which is highly expressed in the PG. Read More

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