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    1 OF 588

    Response to Long-term Vitamin D Therapy for Bone Disease in Children With Sickle Cell Disease.
    J Pediatr Hematol Oncol 2018 Apr 17. Epub 2018 Apr 17.
    Division of Pediatric Endocrinology, Columbia University Medical Center.
    Patients with sickle cell disease (SCD) are at risk for bone fragility from multiple factors including vitamin D deficiency. To date, no studies have evaluated the efficacy and safety of long-term vitamin D therapy for bone disease in children with SCD. We report a cohort of 4 children with SCD found to have severe vitamin D deficiency, secondary hyperparathyroidism, and abnormal bone mineral density treated with monthly high-dose oral cholecalciferol over 2 years. Read More

    Primary hyperparathyroidism: recent advances.
    Curr Opin Rheumatol 2018 Apr 13. Epub 2018 Apr 13.
    Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
    Purpose Of Review: The purpose of this review is to describe recent advances and changes in the evaluation and management of primary hyperparathyroidism (PHPT).

    Recent Findings: Although it has long been recognized that asymptomatic PHPT is associated with bone loss, particularly at cortical skeletal sites when evaluated with dual-energy X-ray absorptiometry, new imaging techniques suggest that trabecular skeletal deterioration as well as clinically silent vertebral fractures and nephrolithiasis are common. Nonclassical targets of asymptomatic PHPT as well as the effect of vitamin D deficiency and treatment upon PHPT presentation have been the subject of recent intense investigation. Read More

    Decrement in bone mineral density after parathyroidectomy in a pediatric patient with primary hyperparathyroidism.
    Clin Pediatr Endocrinol 2018 13;27(2):81-86. Epub 2018 Apr 13.
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Primary hyperparathyroidism (PHT) causes increased bone turnover, leading to reduction in bone mineral density (BMD). Parathyroidectomy is a definitive therapy and improves BMD in adult patients with PHT. However, there are no reports regarding alterations of BMD in pediatric or adolescent patients with PHT. Read More

    Identification of Differential Transcriptional Patterns in Primary and Secondary Hyperparathyroidism.
    J Clin Endocrinol Metab 2018 Apr 5. Epub 2018 Apr 5.
    Division of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospitals of Geneva, Switzerland.
    Context: Hyperparathyroidism is associated with hypercalcemia and the excess of parathyroid hormone secretion. However, the alterations in molecular pattern of functional genes during parathyroid tumorigenesis have not been unraveled. We aimed at establishing transcriptional patterns of normal and pathological parathyroid glands (PG) in sporadic primary and secondary hyperparathyroidism (HPT1, 2). Read More

    Parathyroid Autotransplantation During thyroid Surgery. Where we are? A Systematic Review on Indications and Results.
    J Invest Surg 2018 Apr 16:1-8. Epub 2018 Apr 16.
    d Department of Surgery "P. Valdoni" , Sapienza University , Rome , Italy.
    Introduction: Hypoparathyroidism still represents an important concern in thyroid surgery. Careful dissection with identification and preservation of parathyroid glands in situ remains the best way to maintain gland vitality and avoid post-operative failure. Nevertheless, parathyroid glands are still inadvertently removed in up to 11% of cases. Read More

    Hypercalcemic crisis in third trimenon: evaluating the optimal treatment strategy.
    Gynecol Endocrinol 2018 Apr 16:1-4. Epub 2018 Apr 16.
    a Division of Endocrinology, Diabetes and Metabolism , University Hospital Basel , Switzerland.
    Hypercalcemia due to primary hyperparathyroidism during pregnancy is a rare condition and associated with increased morbidity and mortality for the mother and the unborn child. Whereas parathyroidectomy is favored during the second trimester, no clear recommendations exist for its management during the third trimenon. We here report the case of a 26-year-old woman in the 29th week of her first pregnancy, who was admitted to our clinic with hypertension, intra-uterine growth retardation and polyhydramnios. Read More

    Primary hyperparathyroidism and Gougerot disease.
    Eur J Rheumatol 2018 Mar 2;5(1):72-74. Epub 2017 Nov 2.
    Department of Endocrinology, Diabetology and Nutrition, University Hospital Hassan II, Fez, Morocco.
    Primary hyperparathyroidism (PHPT) is a common endocrine disorder caused by the overactivation of the parathyroid glands due to the autonomous production of the parathyroid hormone (PTH). The resultant hypercalcemia leads to a myriad of symptoms. Here we report the case of a 54-year-old female with a previous diagnosis of Gougerot disease, in whom clinical (diffuse bone pain, asthenia polydipsia, and polyuria) and laboratory features (calcium level, 3. Read More

    Better performance of four-dimension computed tomography as a localization procedure in normocalcemic primary hyperparathyroidism.
    J Med Imaging Radiat Oncol 2018 Apr 15. Epub 2018 Apr 15.
    Division of Endocrinology, Diabetes and Metabolic Bone Diseases, Hospital Agamenon Magalhães, University of Pernambuco Medical School, Recife, Brazil.
    Introduction: The multi-phase or four-dimensional computed tomography (4D CT) has emerged as a promising technique for preoperative localization of parathyroid lesions in patients with primary hyperparathyroidism (PHPT), but little is known about its accuracy in patients with normocalcemic primary hyperparathyroidism (NPHPT).

    Methods: A total of 18 patients diagnosed with PHPT underwent three methods of preoperative localization (4D CT, TC-99-Sestamibi scintigraphy and ultrasonography). After surgery, the results of imaging were compared with operative findings, pathological and biochemical data to evaluate the sensitivity and of each localization procedure. Read More

    Effect of Hybrid Blood Purification Treatment on Secondary Hyperparathyroidism for Maintenance Hemodialysis Patients.
    Blood Purif 2018 Apr 12;46(1):19-26. Epub 2018 Apr 12.
    Objective: This study aims to investigate the effects of hybrid blood purification treatment on secondary hyperparathyroidism for maintenance hemodialysis (HD) patients.

    Methods: A total of 40 patients were randomly divided into 2 groups: HD combined with hemoperfusion (HD + HP) group (n = 20) and HD group (n = 20). Changes in intact parathyroid hormone (iPTH) in these 2 groups were compared before and after treatment, and iPTH levels in the HD + HP group were monitored before and after treatment. Read More

    Uptake of Tc-MIBI by Sclerosing Pneumocytoma Raising a False Suspicion of Metastasis From Medullary Thyroid Carcinoma.
    J Endocr Soc 2018 Apr 23;2(4):386-390. Epub 2018 Mar 23.
    Service of Endocrinology, Diabetology and Metabolism, CHUV, Lausanne University Hospital, Lausanne, Switzerland.
    Technetium-99m methoxy isobutyl isonitrile (Tc-MIBI; sestamibi) single-photon emission computed tomography (SPECT)/computed tomography (CT) performed for preoperative localization of parathyroid adenomas or for other indications can reveal incidentalomas. Interpretation of such findings can be challenging, particularly when thyroid or other endocrine tumors are also present. Preoperative staging of a 59-year-old female patient with medullary thyroid carcinoma (MTC) showing moderate hypermetabolism on F-fluorodeoxyglucose positron emission tomography/CT also detected a slightly hypermetabolic pulmonary nodule (standardized uptake value normalized by body weight max = 2. Read More

    Clinical management of patients on peritoneal dialysis in Italy: results from the ATENA study.
    Clin Kidney J 2018 Apr 12;11(2):275-282. Epub 2017 Sep 12.
    A.O.U. Policlinico di Bari U.O.C. di Nefrologia, Bari, Italy.
    Background: In Italy, few studies have examined the clinical management of peritoneal dialysis (PD) patients, resulting in a lack of information and awareness.

    Methods: A total of 378 PD patients (64.7 ± 14. Read More

    Clinical course after parathyroidectomy in adults with end-stage renal disease on maintenance dialysis.
    Clin Kidney J 2018 Apr 17;11(2):265-269. Epub 2017 Aug 17.
    Department of Nephrology, Serdang Hospital, Malaysia.
    Background: Parathyroidectomy (PTX) is done in cases of secondary hyperparathyroidism from chronic kidney disease to improve renal osteodystrophy. Despite this widespread practice, clinical outcomes regarding the benefits of this procedure are still lacking. Most studies in the literature have opted to report the laboratory outcome instead. Read More

    Unusually Large Brown tumor of Mandible in a Case of Secondary Hyperparathyroidism Mimicking Cherubism.
    Indian J Nucl Med 2018 Apr-Jun;33(2):132-135
    Medanta Division of Radiology and Nuclear Medicine, Medanta The Medicity Hospital, Gurugram, Delhi, NCR, India.
    We report here a case of unusually large brown tumor of mandible mimicking cherubism in a patient with secondary hyperparathyroidism (HPT). The patient is a young male with a large head and a protruding jaw with an open mouth appearance. Initial clinical appearance looked like cherubism. Read More

    [Transoral thyroid and parathyroid surgery : Implementation and evaluation of the transoral endoscopic technique via the vestibular approach (TOETVA)].
    Chirurg 2018 Apr 10. Epub 2018 Apr 10.
    Klinik für Chirurgie, Landesklinikum Wiener Neustadt, Wien, Österreich.
    Background: More than 10 years ago various research groups in Germany first reported the possibility of transoral surgery of the thyroid and parathyroid glands. These were developed and evaluated within the framework of natural orifice transluminal endoscopic surgery (NOTES). While development of these innovative and new techniques that enabled surgery without visible scars did not become well accepted in Europe and America, it led to an optimized transoral endoscopic thyroidectomy vestibular approach (TOETVA), which was implemented particularly in Asia. Read More

    Effects of FGF-23-mediated ERK/MAPK signaling pathway on parathyroid hormone secretion of parathyroid cells in rats with secondary hyperparathyroidism.
    J Cell Physiol 2018 Apr 10. Epub 2018 Apr 10.
    Department of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China.
    This study is supposed to investigate the effect of FGF-23 on parathyroid hormone (PTH) secretion through ERK/MAPK signaling pathway in secondary hyperparathyroidism (SHPT) rat model. Thirty rats were equally served as the normal and SHPT groups. After transfection, parathyroid cells was assigned into blank, NC, pcDNA3. Read More

    [Cyclophosphamide in idiopathic nephrotic syndrome: Outcome and outlook].
    Nephrol Ther 2018 Apr 1;14(2):85-90. Epub 2018 Mar 1.
    Service de pédiatrie B, CHU Mohamed VI, avenue Ibn Sina Amerchich, BP 2360, Marrakech-principal, Maroc.
    Introduction: Cyclophosphamide (CYP) has been used for over 40 years in patients with steroid-sensitive nephrotic syndrome (NSSS) presenting frequent relapses (NSRF) or steroid dependence (NSSD). However, the long-term success of treatment with cyclophosphamide is difficult to predict. The objectives of this study are to determine long-term outcomes of cyclophosphamide and identify the factors associated with sustained remission. Read More

    Hemodialysis-induced cardiovascular disease.
    Semin Dial 2018 Apr 6. Epub 2018 Apr 6.
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.
    More than half of all deaths among end stage renal disease (ESRD) patients are due to cardiovascular disease (CVD). Cardiovascular changes secondary to renal dysfunction, including fluid overload, uremic cardiomyopathy, secondary hyperparathyroidism, anemia, altered lipid metabolism, and accumulation of gut microbiota-derived uremic toxins like trimethylamine N-oxidase, contribute to the high risk for CVD in the ESRD population. In addition, conventional hemodialysis (HD) itself poses myocardial stress and injury on the already compromised cardiovascular system in uremic patients. Read More

    Bone mineral density in primary care patients related to serum calcium concentrations: a longitudinal cohort study from Sweden.
    Scand J Prim Health Care 2018 Apr 6:1-9. Epub 2018 Apr 6.
    a Institute of Medicine/Dept. of Public Health and Community/Primary Health Care , Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.
    Objective: Elevated calcium concentration is a commonly used measure in screening analyses for primary hyperparathyroidism (pHPT) and cancer. Low bone mineral density (BMD) and osteoporosis are common features of pHPT and strengthen the indication for parathyroidectomy. It is not known whether an elevated calcium concentration could be a marker of low BMD in suspected pHPT patients with a normal parathyroid hormone concentration. Read More

    Concurrent primary hyperparathyroidism and pheochromocytoma in a Chinese lady with neurofibromatosis type 1.
    Endocrinol Diabetes Metab Case Rep 2018 28;2018. Epub 2018 Mar 28.
    Department of Medicine and Geriatrics, Caritas Medical Centre, Shamshuipo, Kowloon, Hong Kong SAR.
    We report a case of elderly Chinese lady with neurofibromatosis type-1 presenting with longstanding palpitation, paroxysmal hypertension and osteoporosis. Biochemical testing showed mild hypercalcaemia with non-suppressed parathyroid hormone level suggestive of primary hyperparathyroidism, and mildly elevated urinary fractionated normetanephrine and plasma-free normetanephrine pointing to a catecholamine-secreting pheochromocytoma/paraganglioma. Further scintigraphic investigation revealed evidence of a solitary parathyroid adenoma causing primary hyperparathyroidism and a left pheochromocytoma. Read More

    A rare case of hypercalcemia-induced pancreatitis in a first trimester pregnant woman.
    Endocrinol Diabetes Metab Case Rep 2018 28;2018. Epub 2018 Mar 28.
    Rafic Hariri University Hospital, Beirut, Lebanon.
    The objective of the study is to report a case of acute pancreatitis secondary to hypercalcemia induced by primary hyperparathyroidism in a pregnant woman at the end of the first trimester. The case included a 32-year-old woman who was diagnosed with acute pancreatitis and severe hypercalcemia refractory to many regimens of medical therapy in the first trimester of pregnancy. She was successfully treated with parathyroidectomy in the early second trimester with complete resolution of hypercalcemia and pancreatitis. Read More

    Interrelated role of Klotho and calcium-sensing receptor in parathyroid hormone synthesis and parathyroid hyperplasia.
    Proc Natl Acad Sci U S A 2018 Apr 4;115(16):E3749-E3758. Epub 2018 Apr 4.
    Division of Bone and Mineral Research, Harvard School of Dental Medicine, Boston, MA 02115;
    The pathogenesis of parathyroid gland hyperplasia is poorly understood, and a better understanding is essential if there is to be improvement over the current strategies for prevention and treatment of secondary hyperparathyroidism. Here we investigate the specific role of Klotho expressed in the parathyroid glands (PTGs) in mediating parathyroid hormone (PTH) and serum calcium homeostasis, as well as the potential interaction between calcium-sensing receptor (CaSR) and Klotho. We generated mouse strains with PTG-specific deletion of Klotho and CaSR and dual deletion of both genes. Read More

    High fear of disease occurrence is associated with low quality of life in patients with Multiple Endocrine Neoplasia type 1 (MEN1): Results from the Dutch MEN1 Study Group.
    J Clin Endocrinol Metab 2018 Mar 30. Epub 2018 Mar 30.
    Department of Endocrine Oncology, University Medical Center Utrecht, The Netherlands.
    Objective: Multiple Endocrine Neoplasia type 1 (MEN1) is a hereditary disease characterized by a high risk of developing primary hyperparathyroidism, duodenopancreatic neuroendocrine tumors (dpNETs) and pituitary tumors (PIT). Up to now, it is unclear if having MEN1 leads to psychological distress because of fear of disease occurrence (FDO), thereby potentially affecting quality of life.

    Design: A cross-sectional study was performed using the Dutch MEN1 cohort. Read More

    Clinical presentation and management of patients with primary hyperparathyroidism in Italy.
    J Endocrinol Invest 2018 Apr 3. Epub 2018 Apr 3.
    Department of Clinical and Experimental Medicine, University of Pisa, Via Paradisa 2, 56100, Pisa, Italy.
    Purpose: Evaluation of the phenotype of primary hyperparathyroidism (PHPT), adherence to International Guidelines for parathyroidectomy (PTx), and rate of surgical cure.

    Method: From January 2014-January 2016, we performed a prospective, multicenter study in patients with newly diagnosed PHPT. Biochemical and instrumental data were collected at baseline and during 1-year follow-up. Read More

    Aortic stenosis is a risk factor for all-cause mortality in patients on dialysis: a multicenter prospective cohort analysis.
    BMC Nephrol 2018 Apr 3;19(1):80. Epub 2018 Apr 3.
    Department of Nephrology, Fujita Health University, Toyoake, Aichi, Japan.
    Background: Aortic stenosis (AS) is common in patients on dialysis as well as in the general population. AS leads to difficulty with dialysis therapy because of unstable conditions such as intradialytic hypotension due to low cardiac output. However, the precise morbidity rates and risk factors of AS in patients on dialysis are unknown. Read More

    A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro.
    PLoS One 2018 3;13(4):e0195316. Epub 2018 Apr 3.
    Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Kanagawa, Japan.
    Cinacalcet hydrochloride (cinacalcet), an oral calcimimetic agent has been widely used for the management of secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD). In sharp contrast to vitamin D receptor activators, cinacalcet suppresses SHPT without inducing hypercalcemia or hyperphosphatemia. Nevertheless, some patients remain refractory to SHPT with this agent, as the dose cannot be sufficiently increased due to gastrointestinal symptoms. Read More

    Pseudogout - a rare manifestation of hungry bone syndrome after focused parathyroidectomy.
    Ann R Coll Surg Engl 2018 Apr 1:e1-e3. Epub 2018 Apr 1.
    Division of General Surgery (Thyroid and Endocrine Surgery), University Surgical Cluster, Department of Surgery, National University Health System , Singapore.
    Pseudogout, also known as calcium pyrophosphate deposition disease, is a rheumatological condition arising from accumulation of calcium pyrophosphate dihydrate crystals in connective tissues. We present a case of a 56-year-old Bangladeshi woman who underwent focused right inferior parathyroidectomy for primary hyperparathyroidism from a right inferior parathyroid adenoma. On the first post-operative day, she complained of left elbow painful swelling with redness and warmth. Read More

    Preterm Parturient with Polyhydramnios and Pancreatitis: Primary Presentation of Hyperparathyroidism.
    Case Rep Obstet Gynecol 2018 21;2018:2091082. Epub 2018 Jan 21.
    Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Objective: To report a case of severe hypercalcemia secondary to primary hyperparathyroidism in a late-preterm pregnant patient and review medical and surgical treatments as well as obstetric and neonatal outcomes.

    Background: Diagnosis of parathyroid disease during pregnancy can be difficult due to nonspecific presentation. Management decisions are complex and require multidisciplinary collaboration. Read More

    A phase I, open-label, single-dose micro tracer mass balance study of C-labeled ASP7991 in healthy Japanese male subjects using accelerator mass spectrometry.
    Drug Metab Pharmacokinet 2018 Apr 7;33(2):118-124. Epub 2018 Mar 7.
    Research Program Management, Astellas Pharma Inc., 21 Miyukigaoka Tsukuba-shi, Ibaraki, 305-8585, Japan. Electronic address:
    ASP7991 is a calcimimetic that acts on the calcium-sensing receptor on parathyroid cell membranes and suppresses parathyroid hormone (PTH) secretion in the treatment of secondary hyperparathyroidism. The mass balance and metabolite profile of [C]ASP7991 were investigated in six healthy male subjects after a single oral dose of [C]ASP7991 [1 mg, 18.5 kBq (500 nCi)] in solution. Read More

    Brown tumor of the jaws as a manifestation of tertiary hyperparathyroidism: A literature review and case report.
    Spec Care Dentist 2018 Mar 30. Epub 2018 Mar 30.
    Postgraduate Program, Dental College, Pontifical Catholic University of Rio Grande do Sul-PUCRS.
    Brown tumor of the jaws is a manifestation of hyperparathyroidism consisting of osteolytic lesions that show proliferation of multinucleated giant cells in the maxilla and/or mandible. Differential diagnosis of these lesions from local central giant-cell granuloma is mandatory for the correct treatment of the patient. Radiographic and histopathological exams of the jaw lesion are not sufficient to determine the diagnosis, which requires laboratory tests including serum levels of calcium, alkaline phosphatase, parathyroid hormone (PTH) and phosphate, and radiographic examination of other bones as well, such as hand-wrist, pelvis, and femur. Read More

    A light in the control of secondary hyperparathyroidism. Etelcalcetide IV in hemodialysis.
    Nefrologia 2018 Mar 27. Epub 2018 Mar 27.
    Servicio de Nefrología, Hospital Universitario de Guadalajara, Guadalajara, España; Departamento de Medicina y Especialidades Médicas, Universidad de Alcalá de Henares (UAH), Alcalá de Henares, Madrid, España.

    Vitamin D and Secondary Hyperparathyroid States.
    Front Horm Res 2018 29;50:138-148. Epub 2018 Mar 29.
    The interplay between vitamin D and parathyroid hormone (PTH) represents one of the most important metabolic mechanisms of regulation of the calcium/phosphorus homeostasis. Secondary hyperparathyroidism is therefore a major complication that arises as a result of reduced vitamin D levels, both as primary 25-hydroxy-vitamin D (25[OH]D) and/or 1,25-dihydroxyvitamin D (1,25[OH]2D) reduction. Different metabolic pathways are involved, as well as target organs and tissues, with several clinical complications. Read More

    Refractory hyperparathyroidism with a T3 bony lesion-differential diagnoses.
    Oxf Med Case Reports 2018 Mar 20;2018(3):omx109. Epub 2018 Mar 20.
    Department of Endocrinology & Diabetes, Barwon Health, Geelong, Vic 3220, Australia.
    We report a case of severe hyperparathyroidism complicated by osteitis fibrosa cystica in an 83-year-old man post-myocardial infarction. The lesions were evident on magnetic resonance imaging only. A diagnosis of parathyroid carcinoma was considered due to clinical appearance of the parathyroid intraoperatively and the presence of an invasive T3 lesion mimicking metastatic disease. Read More

    Long-term effects of low calcium dialysates on the serum calcium levels during maintenance hemodialysis treatments: A systematic review and meta-analysis.
    Sci Rep 2018 Mar 28;8(1):5310. Epub 2018 Mar 28.
    Department of iPS Cell Research & Epigenetic Medicine, Keio University School of Medicine, Tokyo, Japan.
    Hypercalcemia and hyperparathyroidism in patients receiving maintenance hemodialysis (MHD) can cause the progression of cardiovascular diseases (CVD) and mineral bone disorders (MBD). The KDIGO recommends the dialysates with a calcium (Ca) concentration of 1.25-1. Read More

    Localisation of ectopic mediastinal parathyroid adenoma by 18F-fluorocholine PET/CT.
    BMJ Case Rep 2018 Mar 28;2018. Epub 2018 Mar 28.
    Division of Endocrinology, Diabetes and Clinical Nutrition, Luzerner Kantonsspital, Luzern, Switzerland.
    We report the case of two patients with newly diagnosed primary hyperparathyroidism: a 40-year-old woman during pregnancy and a 60-year-old man with initial hypercalcaemic crisis. In the first case, a bilateral neck exploration with parathyroidectomy during the second trimester of pregnancy was unsuccessful and the patient remained hypercalcaemic. Postpartum imaging assessment with technetium (Tc)-sestamibi scintigraphy could not supply conclusive diagnostic results. Read More

    Endocrinopathies and renal outcomes in lithium therapy: impact of lithium toxicity.
    QJM 2017 Dec;110(12):821-827
    From the Department of Endocrinology.
    Background: Lithium is the mainstay of treatment for bipolar disorder, mania and an augmentation therapy in patients with treatment resistant depression. It has a narrow therapeutic index, with recognized adverse multi-system and endocrine side effects.

    Aim: To assess the impact of lithium therapy, in particular lithium toxicity, on the development of endocrine and renal disorders in a cohort of patients in a single tertiary referral centre in Ireland. Read More

    Clinical Impact of p27 and CaSR Expression on Primary Hyperparathyroidism.
    Endocr Pathol 2018 Mar 27. Epub 2018 Mar 27.
    Department of Endocrinology and Metabolism, Ankara University Faculty of Medicine, Ankara, Turkey.
    We aimed to investigate the expressions of p27 kinase inhibitory protein 1 (p27 ) and calcium sensing receptor (CaSR) in adenomas and normal parathyroid tissue and to evaluate the relationship of these molecules with clinical and biochemical parameters in primary hyperparathyroidism (PHPT). Fifty-one patients with histopathologically confirmed parathyroid adenomas and 20 patients with normal parathyroid glands (which were removed incidentally during thyroid resection) were included. Immunohistochemical stainings of CaSR and p27 were performed in surgical specimens. Read More

    Hip Fracture in a Patient with Primary Hyperparathyroidism: Medical and Surgical Lessons.
    Cureus 2018 Jan 23;10(1):e2104. Epub 2018 Jan 23.
    Trauma & Orthopaedics, Galway University Hospital.
    Hyperparathyroidism is a condition which can be primary, secondary or tertiary and is characterized by increased calcium levels, low phosphate levels, and elevated parathyroid hormone (PTH) levels. Primary hyperthyroidism can cause severe bone resorption leading to bone pains and pathological fracture. We present the case of a patient with severe primary hyperparathyroidism with an atraumatic fracture at the neck of the femur and multiple medical comorbidities presenting a surgical challenge. Read More

    HNF1 homeobox B mutation as a cause for chronic, treatment-resistant hypomagnesaemia.
    Endocrinol Diabetes Metab Case Rep 2018 21;2018. Epub 2018 Mar 21.
    Department of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.
    29-year-old female presenting with an 8-year history of unexplained hypomagnesaemia, which was severe enough to warrant intermittent inpatient admission for intravenous magnesium. Urinary magnesium was inappropriately normal in the context of hypomagnesaemia indicating magnesium wasting. Ultrasound imaging demonstrated unilateral renal cysts and computed tomography of kidneys, ureters and bladder showed a bicornuate uterus. Read More

    Falsely elevated human epididymis protein 4 results and Risk of Ovarian Malignancy Algorithm in polymorbid women after solid organ transplantation: A pilot and case-control study.
    J Clin Lab Anal 2018 Mar 24:e22432. Epub 2018 Mar 24.
    Department of Laboratory Methods, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
    Background: Cancer prevention is essential after transplantation (Tx). The use of HE4 and Risk of Ovarian Malignancy Algorithm (ROMA) is recommended as a tool for selective ovarian cancer screening; however, creatinine is a known confounder. This study assessed the reliability of HE4, CA125, and ROMA after Tx. Read More

    Clinical value of 11C-methionine positron emission tomography in persistent primary hyperparathyroidism-A case report with a mediastinal parathyroid adenoma.
    Int J Surg Case Rep 2018 Mar 15;45:63-66. Epub 2018 Mar 15.
    Department of Otorhinolaryngology, Aarhus University Hospital, Denmark.
    Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder caused by pathologic growth of one or more of the parathyroid glands. Parathyroidectomies (PTX) in patients with PHPT are procedures with low morbidity, few complications, and a high cure rate. However, the parathyroid glands may be found at various anatomical locations and occasionally they are intrathoracic. Read More

    Parathyroid hormone - reference values and association with other bone metabolism markers in very low birth weight infants - pilot study.
    J Matern Fetal Neonatal Med 2018 Mar 21:1-8. Epub 2018 Mar 21.
    b Institute of Clinical Biochemistry and Diagnostics , University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.
    Purpose: The aim of this pilot study was to estimate physiological parathyroid hormone (PTH) levels and their relationship with bone metabolism parameters in otherwise healthy preterm newborns with birth weight 1000-1500 g.

    Methods: PTH, 25(OH)D, S-Ca, S-P, and ALP were analysed from blood samples obtained from 20 preterm infants once a week up to the 36th gestational week.

    Results: Of the total 134 examined serum samples for PTH levels, the estimated range was 1. Read More

    Diagnostic Accuracy of Biomarkers and Imaging for Bone Turnover in Renal Osteodystrophy.
    J Am Soc Nephrol 2018 Mar 19. Epub 2018 Mar 19.
    Academic Unit of Bone Metabolism and.
    Renal osteodystrophy is common in advanced CKD, but characterization of bone turnover status can only be achieved by histomorphometric analysis of bone biopsy specimens (gold standard test). We tested whether bone biomarkers and high-resolution peripheral computed tomography (HR-pQCT) parameters can predict bone turnover status determined by histomorphometry. We obtained fasting blood samples from 69 patients with CKD stages 4-5, including patients on dialysis, and 68 controls for biomarker analysis (intact parathyroid hormone [iPTH], procollagen type 1 N-terminal propeptide [PINP], bone alkaline phosphatase [bALP], collagen type 1 crosslinked C-telopeptide [CTX], and tartrate-resistant acid phosphatase 5b [TRAP5b]) and scanned the distal radius and tibia of participants by HR-pQCT. Read More

    Epidemiology and risk factors in CKD patients with pulmonary hypertension: a retrospective study.
    BMC Nephrol 2018 Mar 20;19(1):70. Epub 2018 Mar 20.
    Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
    Background: Pulmonary hypertension (PH) is a rare disease often associated with high mortality and is recently recognized as a common complication secondary to chronic kidney disease (CKD). Epidemiological data for this disorder across the spectrum of CKD is poorly understood.

    Methods: We retrospectively analyzed 705 CKD patients with complete clinical records from July 2013 to September 2015. Read More

    Bilateral pyriform sinus parathyroid adenomas.
    Ear Nose Throat J 2018 Mar;97(3):E38-E40
    Department of Otolaryngology, Head and Neck Surgery, University of Kansas, 3901 Rainbow Blvd., Kansas City, KS 66160.
    Parathyroid glands undergo a variable descent during embryologic development and can be found anywhere in the neck from the level of the mandible to the mediastinum. To the best of our knowledge, we present the first report of a patient who was found to have bilateral parathyroid adenomas in her pyriform sinuses. A middle-aged woman with renal failure and secondary hyperparathyroidism presented with dysphagia and was found to have bilateral pyriform sinus masses on endoscopy. Read More

    Use of calcimimetics in children with normal kidney function.
    Pediatr Nephrol 2018 Mar 19. Epub 2018 Mar 19.
    Bone and Mineral Disorders Clinic, Division of Nephrology, Children's Mercy Hospital, University of Missouri at Kansas City, 2401Gillham Road, Kansas City, MO, 64108, USA.
    The calcium-sensing receptor (CaSR) plays an important role in the homeostasis of serum ionized calcium by regulating parathyroid hormone (PTH) secretion and tubular calcium handling. Calcimimetics, which act by allosteric modulation of the CaSR, mimic hypercalcemia resulting in suppression of PTH release and increase in calciuria. Mostly used in children to treat secondary hyperparathyroidism associated with advanced renal failure, we have shown that calcimimetics can also be successfully used in children with bone and mineral disorders in which elevated PTH plays a detrimental role in skeletal pathophysiology in the face of normal kidney function. Read More

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