29,527 results match your criteria Hyperparathyroidism


Risk factors of developing the hungry bone syndrome after parathyroidectomy for primary hyperparathyroidism.

Acta Med Litu 2018 ;25(1):45-51

Faculty of Medicine Vilnius University, Vilnius, Lithuania.

Background: Around 13% of patients undergoing parathyroidectomy for primary hyperparathyroidism (PHPT) postoperatively develop a condition known as the hungry bone syndrome (HBS). Although the condition is quite prevalent, the research in this field is very limited. The aim of our study was to determine possible risk factors of developing HBS after parathyroidectomy for PHPT. Read More

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January 2018

Children with MEN1 gene mutations may present first (and at a young age) with Cushing disease.

Clin Endocrinol (Oxf) 2018 Jun 21. Epub 2018 Jun 21.

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland, 20892.

Objective: Cushing disease (CD) is a rare entity caused by ACTH-secreting pituitary tumors, leading to prolonged hypercortisolism. Most cases are sporadic but can rarely occur in the context of familial predisposition, due to germline mutations in genes such as MEN1, leading to multiple endocrine neoplasia type 1, MEN1. We have reported previously that CD can be the first and only presenting manifestation of MEN1. Read More

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Parathyroid carcinoma in multiple endocrine neoplasm type 1 syndrome: case report and systematic literature review.

Clin Exp Med 2018 Jun 20. Epub 2018 Jun 20.

Department of Biomedical Sciences and Human Oncology - Unit of Endocrine, Digestive and Emergency Surgery, University "A. Moro" of Bari. Polyclinic of Bari, Piazza Giulio Cesare, 1, 70124, Bari, Italy.

The aim of this report was to illustrate a case of parathyroid carcinoma (PC) in a patient with multiple endocrine neoplasia type 1 (MEN1) along with a comprehensive literature review. A 61-year-old man presented with 9-cm PC causing primary hyperparathyroidism (PHPT). His pre-operative corrected calcium and intact PTH serum levels were 2. Read More

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F-Fluorocholine-Positron Emission Tomography/Computerised Tomography is Useful in Localising Tc-Sesta-methoxyisobutylisonitrile-Negative Parathyroid Cyst Causing Normocalcemic Primary Hyperparathyroidism.

Eur Endocrinol 2018 Apr 18;14(1):56-58. Epub 2018 Apr 18.

Department of Pathology, Venkateshwar Hospitals, New Delhi, India.

Parathyroid cysts are extremely rare and are rarely associated with primary hyperparathyroidism (PHPT), which are difficult to localise, as they are Tc-sesta-methoxyisobutylisonitrile (sestaMIBI) negative. We report for the first time the utility of F-fluorocholinepositron emission tomography/computerised tomography (PC-PET/CT) in localising parathyroid cyst causing normocalcemic PHPT. A 76-year-old lady with progressively worsening osteoporosis from 2014-2017 (in spite of annual zolendronic acid infusions, daily calcium and vitamin-D supplementation) with persistently normal serum calcium and vitamin D, but elevated parathyroid hormone, had normal sestaMIBI scans of the neck on multiple occasions. Read More

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Clinical utility of bone markers in various diseases.

Bone 2018 Jun 16. Epub 2018 Jun 16.

Department of Clinical Chemistry, Endocrine Laboratory, VU University Medical Center, de Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Clinical Chemistry, Laboratory of Endocrinology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. Electronic address:

Measurements of bone markers (BMs) in peripheral blood or urine are a pivotal part of bone research within modern clinical medicine. In recent years the use of BMs increased substantially as they can be useful either to diagnose bone (related) disease and to follow its natural history, but also to monitor the effects of interventions. However, the use of BMs is still complicated mainly due to (pre)analytical variability of these substances, limited accessibility of assays, variable cut-off values in different countries and laboratories and heterogeneous results with regard to clinical implications of measuring BMs in several studies. Read More

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Severe secondary hyperparathyroidism in patients on haemodialysis is associated with a high initial serum parathyroid hormone and beta-CrossLaps level: Results from an incident cohort.

PLoS One 2018 18;13(6):e0199140. Epub 2018 Jun 18.

NEPHROCARE Tassin-Charcot, Haemodialysis, Sainte Foy-les-Lyon,France.

Background: Secondary hyperparathyroidism (SHPT) is a frequent complication of renal disease and most commonly occurs in patients on haemodialysis (HD) with metabolic, vascular, endocrine, and bone complications. The aim of this study was to analyze the evolution of mineral metabolism parameters during the first 36 months of HD treatment and identify the initial factors associated with severe SHPT.

Methods: Serum parathyroid hormone (PTH), calcium and phosphate levels were measured monthly; bone-specific alkaline phosphatase (b-ALP) and beta-CrossLaps (CTX) were measured biannually. Read More

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Role of etelcalcetide in the management of secondary hyperparathyroidism in hemodialysis patients: a review on current data and place in therapy.

Drug Des Devel Ther 2018 1;12:1589-1598. Epub 2018 Jun 1.

Department of Internal Medicine III, Nephrology and Dialysis, Feldkirch Academic Teaching Hospital, Feldkirch, Austria.

Secondary hyperparathyroidism (sHPT) is a frequently occurring severe complication of advanced kidney disease. Its clinical consequences include extraskeletal vascular and valvular calcifications, changes in bone metabolism resulting in renal osteodystrophy, and an increased risk of cardiovascular morbidity and mortality. Calcimimetics are a cornerstone of parathyroid hormone (PTH)-lowering therapy, as confirmed by the recently updated 2017 Kidney Disease: Improving Global Outcomes chronic kidney disease - mineral and bone disorder clinical practice guidelines. Read More

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June 2018
2 Reads

Update on multiple endocrine neoplasia Type 1 and 2.

Presse Med 2018 Jun 13. Epub 2018 Jun 13.

Centre hospitalier de Saint-Denis, service d'endocrinologie, 2, rue du Docteur-Delafontaine, BP 279, 93205 Saint-Denis cedex, France. Electronic address:

Multiple endocrine neoplasia type 1 is a rare genetic syndrome, characterized by the co-occurrence, in the same individual or in related individuals of the same family, of hyperparathyroidism, duodenopancraetic neuroendocrine tumors, pituitary adenomas, adrenocortical tumors, and neuroendocrine tumors (carcinoids) in the thymus, the bronchi, or the stomach. Multiple endocrine neoplastic type 2 is a rare genetic syndrome, characterized by the familial occurrence of medullary thyroid carcinoma either isolated or associated with pheochromocytoma, primary hyperparathyroidism, or typical features (Marfanoid habitus, mucosal neuromas). Subjects with clinical MEN1 and those who carry a mutation in the MEN1 gene should be offered biochemical and imaging screening in order to detect tumors and evaluate their progression over time. Read More

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June 2018
1 Read

Gyriform calcifications after ischemic stroke in a patient with primary hyperparathyroidism.

Presse Med 2018 Jun 13. Epub 2018 Jun 13.

University Hospital of Pointe-à-Pitre, Neurology Department, route de Chauvel, 97139 Abymes, Guadeloupe.

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Impacts of parathyroidectomy on calcium and phosphorus metabolism disorder, arterial calcification and arterial stiffness in haemodialysis patients.

Asian J Surg 2018 Jun 13. Epub 2018 Jun 13.

Department of Rheumatology and Nephrology, General Hospital of Air Force, Haidian District, Beijing, 100142, China. Electronic address:

Background: Secondary hyperparathyroidism (SHPT) and calcium and phosphorus metabolism disorder are important complications in haemodialysis patients. Parathyroidectomy (PTX) may prevent or delay the progress of vascular calcification in haemodialysis patients.

Objective: To investigate the impacts of PTX on calcium and phosphorus metabolism, arterial calcification and arterial stiffness in haemodialysis patients with SHPT. Read More

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Changes in bone mineral density after total parathyroidectomy without autotransplantation in the end-stage renal disease patients with secondary hyperparathyroidism.

BMC Nephrol 2018 Jun 15;19(1):142. Epub 2018 Jun 15.

Department of Nephrology, Second Affiliated Hospital of Nanjing Medical University, 262 Zhongshan North Road, Nanjing, Jiangsu Province, China.

Background: The patients with secondary hyperparathyroidism (SHPT) usually had reduced bone mineral density, which might lead to a substantial increase in osteoporosis, fracture and mortality. Although surgical intervention is effective in reducing parathyroid hormone (PTH) levels in suitable candidates refractory to medical therapy, the effect of surgery on bone mass changes still requires further evaluation. Thus, the aim of this study was to evaluate the characteristics of BMD changes after total parathyroidectomy (PTX) without autotransplantation and its associated factors. Read More

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Skeletal Consequences of Nephropathic Cystinosis.

J Bone Miner Res 2018 Jun 15. Epub 2018 Jun 15.

Skeletal Disorders and Mineral Homeostasis Section, National Institutes of Health, Bethesda, MD, United States.

Nephropathic cystinosis is a rare lysosomal storage disorder. Patients present in the first year of life with renal Fanconi syndrome that evolves to progressive chronic kidney disease (CKD). Despite the multiple risk factors for bone disease, the frequency and severity of skeletal disorders in nephropathic cystinosis have not been described. Read More

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June 2018
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Calcitriol accelerates vascular calcification irrespective of vitamin K status in a rat model of CKD with hyperphosphatemia and secondary hyperparathyroidism.

J Pharmacol Exp Ther 2018 Jun 14. Epub 2018 Jun 14.

Queen's University.

Patients with chronic kidney disease have a markedly increased risk for developing cardiovascular disease. Non-traditional risk factors, such as increased phosphate retention, and deficiencies in vitamins D and K metabolism, likely play key roles in the development of vascular calcification during CKD progression. Calcitriol (1,25-(OH)2-D3) is a key transcriptional regulator of Matrix Gla protein (MGP), a vitamin K dependent protein that inhibits vascular calcification. Read More

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June 2018
3 Reads

Quality of life in multiple endocrine neoplasia type 2A compared with normative and disease populations.

Surgery 2018 Jun 11. Epub 2018 Jun 11.

Northwestern University Feinberg School of Medicine, Department of Surgery, Chicago, IL, USA. Electronic address:

Background: Patient-reported outcomes are measured in chronic disease states to inform intervention and management decisions while minimizing negative outcomes. We hypothesized that health-related quality of life in patients with multiple endocrine neoplasia type 2A would be worse than the general US population but similar to other chronic diseases.

Methods: Adults ≥18 years with multiple endocrine neoplasia type 2A were recruited to complete the Patient-Reported Outcomes Measurement Information System 29-item questionnaire (n = 45). Read More

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June 2018
1 Read

Mineral and bone disorders in conventional hemodialysis: Challenges and solutions.

Authors:
Takayuki Hamano

Semin Dial 2018 Jun 13. Epub 2018 Jun 13.

Department of Inter-Organ Communication Research in Kidney Disease, Osaka University Graduate School of Medicine, Osaka, Japan.

Despite the advent of cinacalcet and noncalcium-containing phosphate binders, controlling the progression of vascular calcification (VC) is still challenging. Recent reports demonstrate that carbamylation driven by high urea concentration aggravates VC, suggesting the importance of adequate dialysis in retarding its progression. Theoretically, other promising measures include the use of iron-based phosphate binders, vitamin K, and magnesium supplements, which should be investigated in future randomized controlled trials (RCTs), ideally with hard outcomes. Read More

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Successful use of cinacalcet to treat parathyroid-related hypercalcemia in two pediatric patients.

Endocrinol Diabetes Metab Case Rep 2018 6;2018. Epub 2018 Jun 6.

Department of Pediatric Endocrinology, Children's University Hospital Vall Hebron, Barcelona, Spain.

Two pediatric patients with different causes of hyperparathyroidism are reported. First patient is a 13-year-old male with severe hypercalcemia due to left upper parathyroid gland adenoma. After successful surgery, calcium and phosphate levels normalized, but parathormone levels remained elevated. Read More

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Rapid calcium loss may cause arrhythmia in hemofiltration with regional citrate anticoagulation: a case report.

BMC Nephrol 2018 Jun 14;19(1):136. Epub 2018 Jun 14.

Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

Background: Renal replacement therapy (RRT) with regional citrate anticoagulation (RCA) is an important therapeutic approach for refractory hypercalcemia complicated with renal failure. However, RCA has the potential to induce arrhythmia caused by rapid calcium loss. We report a case of arrhythmia associated with rapid calcium loss during RCA-RRT. Read More

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June 2018
1 Read

Recent Topics Around Multiple Endocrine Neoplasia Type 1.

Authors:
Stephen J Marx

J Clin Endocrinol Metab 2018 Apr;103(4):1296-1301

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is complex with regard to clinical expressions, management, and molecular pathways. Advances are being made broadly and in focused aspects. Selected topics are presented for their developments since publication of the most recent MEN1 consensus guidelines 6 years ago. Read More

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April 2018
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Subchondral Bone Restoration of Supra-acetabular Brown Tumor Secondary to Parathyroid Carcinoma: A Case Report.

Hip Pelvis 2018 Jun 4;30(2):120-124. Epub 2018 Jun 4.

Department of Orthopedic Surgery, Center for Joint Disease, Chonnam National University Hwasun Hospital, Hwasun, Korea.

The causes of osteolytic lesions found in radiological examinations are not quite certain. Therefore, to determine the appropriate treatment method, various approaches and analyzes are required to find the real cause. Hyperparathyroidism is one of the diseases which forms osteolytic bone lesions so-called brown tumor. Read More

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Metabolic Syndrome in Parathyroid Diseases.

Front Horm Res 2018 5;49:67-84. Epub 2018 Apr 5.

Parathyroid glands are the main regulator of body mineral metabolism through parathormone (PTH) actions on bone and kidney. Experimental evidence suggests that PTH may have non-classical target organs such as adipose tissue, arterial vascular wall, cardiac muscle cells, and adrenal cortex cells, where it may play a role in controlling body energy, blood pressure, and metabolism. Cardiometabolic features have been investigated in the wide spectrum of clinical parathyroid disorders, from hyperparathyroidism to pseudohypoparathyroidism and hypoparathyroidism. Read More

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April 2018
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Severe Acute Pancreatitis as an Index Clinical Manifestation of Parathyroid Adenoma.

Cureus 2018 Apr 7;10(4):e2445. Epub 2018 Apr 7.

Department of Internal Medicine, SBH Health System, 4422 Third Ave, Bronx, Ny 10457.

Hypercalcemia due to primary or secondary hyperparathyroidism is a rare and obscure cause of acute pancreatitis. Although a rare occurrence to begin with, hyperparathyroidism commonly manifests with symptoms of hypercalcemia. Thus, it would reason that a patient might develop pancreatitis by way of hypercalcemia due to primary or secondary hyperparathyroidism. Read More

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[Clinical analysis of reoperation for secondary hyperparathyroidism].

Zhonghua Wai Ke Za Zhi 2018 Jun;56(6):442-446

Department of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China.

To investigate the safety and efficacy for reoperation after parathyroidectomy for persistent and recurrent secondary hyperparathyroidism (HPT). Totally 10 patients with persistent or recurrent HPT who underwent parathyroidectomy reoperation at Department of General Surgery, China-Japan Friendship Hospital from April 2001 to October 2012 were selected. Among them, 6 were male and 4 were female with age of (46. Read More

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Parathyroid Hormone and Bone in Dialysis Patients.

Ther Apher Dial 2018 Jun;22(3):229-235

Division of Comprehensive Geriatrics in Community, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Bone maintains extracellular calcium levels through a system called bone remodeling. Parathyroid hormone (PTH) is the major initiator of this system, which is secreted by the information through calcium sensing receptor in parathyroid cells. PTH modifies calcified bone morphology through a process of its bone action. Read More

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June 2018
1 Read

[Pseudotumoral calcinosis in a patient on chronic hemodialysis].

Pan Afr Med J 2017 21;28:250. Epub 2017 Nov 21.

Service de Néphrologie, CHU Hassan II, Fès, Maroc.

Pseudotumoral calcinosis (PTC) is characterized by calcium phosphate crystal deposition in periarticular soft tissues leading to the development of large calcified masses. Although PTC physiopathogeny is not completely clear, the increase in calcium-phosphorus product beyond the threshold value for precipitation as well as severe hyperparathyroidism seem to play a determining role. PTC may even cause recurrent minor joint traumas. Read More

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Denosumab-induced normocalcemic hyperparathyroidismin in a woman with postmenopausal osteoporosis and normal renal function.

Curr Drug Saf 2018 Jun 7. Epub 2018 Jun 7.

Department of Internal Medicine, Naval Hospital of Crete, Chania. Greece.

Elevations in serum parathyroid hormone (PTH) levels after denosumab administration have been described in medical literature among patients with renal impairment or intestinal malabsortion syndromes. We present the first case of denosumab-induced normocalcemic hyperparathyroidism in a woman with postmenopausal osteoporosis without renal impairment or malabsorption syndrome. Read More

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June 2018
1 Read

Correction: Familial Hyperparathyroidism - Disorders of Growth and Secretion in Hormone-Secretory Tissue.

Horm Metab Res 2017 Nov 7;49(11):e4. Epub 2018 Jun 7.

Hospital das Clinicas, University of São Paulo School of Medicine Sao Paulo, Sao Paulo, Brazil.

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November 2017
1 Read

Treatment Based on Cinacalcet Reduces Oxidative Stress in Hemodialysis Patients with Secondary Hyperparathyroidism.

Nephron 2018 Jun 7:1-7. Epub 2018 Jun 7.

Department of Nephrology, Transplantation and Internal Medicine, Katowice, Poland.

Background/aims: Oxidative stress is one of the leading factors contributing to increased mortality in patients with chronic kidney disease (CKD) and secondary hyperparathyroidism (sHPT). Cinacalcet is now commonly used in the treatment of sHPT in patients with CKD. The aim of this study was to assess the influence of treatment with cinacalcet on the oxidative stress markers in patients on hemodialysis with sHPT. Read More

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June 2018
2 Reads

Highly specific preoperative selection of solitary parathyroid adenoma cases in primary hyperparathyroidism by quantitative image analysis of the early-phase Technetium-99m sestamibi scan.

J Med Imaging Radiat Oncol 2018 Jun 7. Epub 2018 Jun 7.

Department of Radiology, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA.

Introduction: Highly specific preoperative localizing test is required to select patients for minimally invasive parathyroidectomy (MIP) in lieu of traditional four-gland exploration. We hypothesized that Tc-99m sestamibi scan interpretation incorporating numerical measurements on the degree of asymmetrical activity from bilateral thyroid beds can be useful in localizing single adenoma for MIP.

Methods: We devised a quantitative interpretation method for Tc-99m sestamibi scan based on the numerically graded asymmetrical activity on early phase. Read More

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June 2018
2 Reads

Acute Pancreatitis with Disturbed Consciousness Caused by Hyperparathyroidism.

Intern Med 2018 Jun 6. Epub 2018 Jun 6.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan.

Although hyperparathyroidism has been reported to cause acute pancreatitis, little is known about the mechanism involved. This study describes the case of an 86-year-old woman with acute pancreatitis and consciousness disturbance caused by hyperparathyroidism and hypercalcemia, respectively. The consciousness disturbance caused by severe hypercalcemia probably masked the typical symptoms associated with pancreatitis because she did not report abdominal pain during the clinical course. Read More

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Predictors of Thyroid Gland Invasion in Laryngeal Squamous Cell Carcinoma.

Iran J Otorhinolaryngol 2018 May;30(98):153-158

Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Laryngeal squamous cell carcinoma (SCC) can invade the thyroid gland leading to unnecessary thyroidectomies with subsequent hypothyroidism and hyperparathyroidism. Thus, clinicopathological variables should be defined in order to predict thyroid gland invasion preoperatively.

Materials And Methods: We performed a retrospective analysis of 1,465 patients with laryngeal SCC referred to our center between March 2009 and January 2016. Read More

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Galactosialidosis in a Newborn with a Novel Mutation in the Gene Presenting with Transient Hyperparathyroidism.

Balkan J Med Genet 2017 Dec 29;20(2):95-98. Epub 2017 Dec 29.

Department of Pediatrics, Division of Neonatology, Ankara University School of Medicine, Ankara, Turkey.

Galactosialidosis is a lysosomal storage disease caused by deficiency of protective protein that is encoded by the cathepsin A () gene localized on chromosome 20q13.1. Mutations of this gene are the cause of galactosialidosis that result in loss of function of protective protein. Read More

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December 2017

Absent Tc-MIBI Uptake in the Thyroid Gland during Early Phase of Parathyroid Scintigraphy in Patients with Primary and Secondary Hyperparathyroidism.

Open Access Maced J Med Sci 2018 May 10;6(5):808-813. Epub 2018 May 10.

Institute of Pathophysiology and Nuclear Medicine, Medical Faculty, Ss. Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Background: Thyroid uptake of technetium-99m methoxyisobutylisonitrile (Tc-MIBI) during parathyroid scintigraphy can be affected by various conditions.

Aim: To evaluate the frequency of absent Tc-MIBI uptake by the thyroid gland in the early phase of dual-phase parathyroid scintigraphy.

Methods: The early planar images of dual phase Tc MIBI parathyroid scintigraphy from 217 patients performed between 2014 and 2017 were retrospectively analysed. Read More

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May 2018
2 Reads

REDUCTION OF ARRHYTHMIAS IN PRIMARY HYPERPARATHYROIDISM, BY PARATHYROIDECTOMY, EVALUATED WITH 24 HOUR ECG MONITORING.

Eur J Endocrinol 2018 Jun 6. Epub 2018 Jun 6.

S Minisola, Department of Internal Medicine and Medical Disciplines, "Sapienza" University of Rome, Rome, 00161, Italy.

Objective: Hypercalcemia may induce arrhythmias. There are no data on the prevalence of arrhythmias in primary hyperparathyroidism (PHPT) in daily life. Aim of the study was to investigate both the prevalence of arrhythmias in patients with PHPT compared to controls and the impact of parathyroidectomy, evaluated by 24 hour electrocardiogram (ECG) monitoring. Read More

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June 2018
1 Read

A rural perspective on minimally invasive parathyroidectomy: optimal preoperative imaging and patient outcomes.

ANZ J Surg 2018 Jun 5. Epub 2018 Jun 5.

Breast and Endocrine Surgical Unit, Department of Surgery, Wagga Wagga Rural Referral Hospital, Wagga Wagga, New South Wales, Australia.

Background: Our retrospective review of prospectively collected data evaluated the efficacy of minimally invasive parathyroidectomy (MIP) and compared preoperative imaging modalities in a rural referral centre.

Methods: Patients with a diagnosis of primary hyperparathyroidism underwent surgeon-performed ultrasound (SUS) and technetium-99 m sestamibi (MIBI). Radiologist-performed ultrasound (RUS) was sought when the diagnosis remained in doubt. Read More

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June 2018
3 Reads

Gitelman syndrome and primary hyperparathyroidism: a rare association.

BMJ Case Rep 2018 Jun 5;2018. Epub 2018 Jun 5.

Department of Endocrinology, Hospital Curry Cabral, Lisboa, Portugal.

Gitelman syndrome(GS) is a rare autosomal recessive salt-losing tubulopathy of young adults, characterised by hypokalaemia, hypomagnesaemia, hypocalciuria and secondary hyperaldosteronism. Hypercalcaemia due to hypocalciuria in these patients is extremely rare.A 25-year-old healthy woman was referred to the Endocrinology clinic for evaluation of persistent hypokalaemia. Read More

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June 2018
2 Reads

Rush Fracture Liaison Service for capturing "missed opportunities" to treat osteoporosis in patients with fragility fractures.

Osteoporos Int 2018 Jun 4. Epub 2018 Jun 4.

Division of Endocrinology and Metabolism, Rush University Medical Center, Chicago, IL, USA.

In spite of being a public health problem of pandemic proportions, osteoporosis continues to be underdiagnosed and undertreated especially in older adults with fragility fractures. Confirmation of this hypothesis resulted in the development of a novel Fracture Liaison Service (Rush FLS). Results of the first 12 months of operation revealed that patients with confirmed fragility fracture do not have a timely diagnosis at fracture occurrence or treatment of their disease. Read More

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June 2018
1 Read

Treatment of extreme hypercalcaemia: the role of haemodialysis.

BMJ Case Rep 2018 Jun 4;2018. Epub 2018 Jun 4.

Department of Nephrology, Soroka University Medical Center, Beer Sheva, Israel.

A patient with extremely high calcium level of 23.9 mg/dL (5.97 mmol/L) was admitted to our department unconscious with pathological ECG recording, demonstrating shortening of QT interval. Read More

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June 2018
2 Reads

Risk factors for persistent hyperparathyroidism in children with stable renal function after kidney transplantation.

Pediatr Transplant 2018 Jun 3:e13238. Epub 2018 Jun 3.

Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.

This study aimed to investigate the risk factors for PHPT in children with stable renal function who received KT. We retrospectively analyzed the clinical findings and laboratory results of patients who underwent KT below 19 years of age, between 1996 and 2016 at our hospital. Patients were followed up for more than 1 year after KT. Read More

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June 2018
1 Read

TRPV6 Variants Interfere with Maternal-Fetal Calcium Transport through the Placenta and Cause Transient Neonatal Hyperparathyroidism.

Am J Hum Genet 2018 Jun 31;102(6):1104-1114. Epub 2018 May 31.

Intractable Disease Center, Saitama Medical University Hospital, Saitama 350-1298, Japan.

Transient neonatal hyperparathyroidism (TNHP) is etiologically a heterogeneous condition. One of the etiologies is an insufficient maternal-fetal calcium transport through the placenta. We report six subjects with homozygous and/or compound-heterozygous mutations in the gene encoding the transient receptor potential cation channel, subfamily V, member 6 (TRPV6), an epithelial Ca-selective channel associated with this condition. Read More

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Serum vitamin D in obese and overweight subjects according to estimated glomerular filtration rate.

Hormones (Athens) 2018 Apr 17. Epub 2018 Apr 17.

Department of Endocrinology, University of Ioannina, 451 10, Ioannina, Greece.

Objective: Obesity and renal disease are both associated with low serum 25(OH)D. The aims of the present study were to (a) assess vitamin D status and compare serum vitamin D levels in overweight/obese versus normal-weight individuals according to eGFR and (b) assess the role of 25(OH)D in the development of secondary hyperparathyroidism (SHPT).

Design: Serum 25(OH)D, 1,25(OH)D, parathyroid hormone (PTH), calcium, and phosphate were measured in 104 subjects with BMI > 25 kg/m. Read More

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Racial Variations in the Markers of Mineral Bone Disorders in CKD Patients in South Africa.

Kidney Int Rep 2018 May 12;3(3):583-591. Epub 2017 Dec 12.

Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Introduction: Several studies showed that serum intact parathyroid hormone (PTH), phosphate, and vitamin D levels differ across races. These comparative studies were largely carried out between Caucasians and black Americans. However, little is known of the existence of these associations in an African population with chronic kidney disease (CKD). Read More

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May 2018
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Is There Association between Vitamin D Concentrations and Body Mass Index Variation in Women Submitted to Y-Roux Surgery?

J Obes 2018 3;2018:3251675. Epub 2018 May 3.

Faculdade de Medicina do ABC, Santo Andre, SP, Brazil.

Objective: To evaluate vitamin D deficiency and body composition of women submitted to bariatric surgery and relate their body mass index variation after surgery to 25(OH)D concentrations.

Method: A cross-sectional and controlled study was performed including 49 obese adult volunteer women, submitted to Roux-en-Y gastric bypass (RYGB group).

Collected Data: Body mass index (BMI), self-declared ethnicity, economic condition, physical activity level, serum concentrations of 25-hydroxycholecalciferol (25(OH)D; radioimmunoassay), parathormone, and body composition by dual-energy X-ray absorptiometry (Hologic DXA-QDR-1000) were collected. Read More

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Mandibular Osteitis Fibrosa Cystica as First Sign of Vitamin D Deficiency.

Case Rep Dent 2018 15;2018:6814803. Epub 2018 Apr 15.

Oral Health and Oro-Facial Rehabilitation Laboratory Research (LR12ES11), Faculty of Dental Medicine, University of Monastir, Avenue Avicenne, 5019 Monastir, Tunisia.

Introduction: Brown tumors of hyperparathyroidism are locally destructive bone lesions. They are the late clinical consequence of the disease. They can occur in primary, secondary, and rarely tertiary forms. Read More

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April 2018
2 Reads

Primary hyperparathyroidism in prostate cancer: guilty or not guilty?

Endocrine 2018 May 30. Epub 2018 May 30.

Medical Oncology, 'Maggiore della Carità' University Hospital, Novara, Italy.

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May 2018
1 Read

Sclerostin in chronic kidney disease-mineral bone disorder think first before you block it!

Nephrol Dial Transplant 2018 May 24. Epub 2018 May 24.

Department of Nephrology, University Hospital of the RWTH Aachen, Aachen, Germany.

Canonical Wnt signalling activity is a major player in physiological and adaptive bone metabolism. Wnt signalling is regulated by soluble inhibitors, with sclerostin being the most widely studied. Sclerostin's main origin is the osteocyte and its major function is blockade of osteoblast differentiation and function. Read More

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Subclinical Vitamin D Deficiency in Children from Thrissur, Kerala.

Indian Pediatr 2018 05;55(5):434-435

Department of Pediatrics, Government Medical College, Thrissur, Kerala, India.

This study was conducted to assess the 25-hydroxy vitamin D levels in children (age 1-5 yr) from Thrissur, Kerala, and to find its association with clinical manifestations of vitamin D-deficiency. Among the 79 children included, none had clinical features of rickets. The mean (range) vitamin D level was 18. Read More

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The Effects of Diuretics on Mineral and Bone Metabolism.

Authors:
Uri S Alon

Pediatr Endocrinol Rev 2018 Mar;15(4):291-297

Division of Pediatric Nephrology, Children's Mercy Hospital Kansas City, 2401 Gillham Road, Kansas City, MO, USA, E-mail:

The effects of diuretics on water and electrolyte metabolism are well-established, but less known to the clinician are their effects on bone and mineral metabolism, and in particular on that of calcium homeostasis. In general, and clinically most relevant, diuretics acting at the thick ascending limb of the loop of Henle cause loss of calcium into the urine, thus making them a useful tool in treating hypercalcemia. However the hypercalciuria caused by loop diuretics may lead to the development of urolithiasis and nephrocalcinosis, as well as secondary hyperparathyroidism and bone disease. Read More

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All 25-hydroxyvitamin D-deficient Indian postmenopausal women do not have secondary hyperparathyroidism.

Arch Osteoporos 2018 May 27;13(1):62. Epub 2018 May 27.

Department of Medicine, Division of Endocrinology and Metabolism, Maulana Azad Medical College, New Delhi, India.

This study shows a high 25-hydroxyvitamin D deficiency among postmenopausal women accompanying secondary hyperparathyroidism. However, a sizable number of subjects did not have secondary hyperparathyroidism despite having low 25-hydroxyvitamin D levels. This condition arises a research question in clinical practice needed to be addressed in the future. Read More

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[Clinical study of chondrosarcoma in the jugular foramen].

Authors:
F T Li C F Dai

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Sep;31(18):1415-1418

Deparment of Otology and Skull Base Sugery, Eye Ear Nose and Throat Hospital of Fudan University, Hearing Medicine Key Laboratory of the National Health and Family Planning Commission, Shanghai, 200031, China.

To explore the diagnosis and surgical treatment of chondrosarcoma in the jugular foramen (JF).This study lies on the retrospective analysis about 72 patients with secondary hyperparathyroidism who had parathyroid gland resection in our hospital from 2010 to 2017. All of 72 cases are examined by color doppler ultrasound,99mTC-MIBI nuclide imaging and magnetic resonance imaging. Read More

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September 2017

[Three combined imaging studies' diagnostic value for preoperative position of hyperthyroidism].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Sep;31(18):1408-1410

Department of Otolaryngology Head and Neck Surgery, Peking University Civil Aviation School of Clinical Medicine, Civil Aviation General Hospital,Beijing,100123,China.

To investigatethe diagnostic value of three combined imaging studies' preoperative localization for secondary hyperparathyroidism.This study lies on the retrospective analysis about 72 patients with secondary hyperparathyroidism who had parathyroid gland resection in our hospital from 2010 to 2017. All of 72 cases are examined by color doppler ultrasound,99mTC-MIBI nuclide imaging and magnetic resonance imaging. Read More

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September 2017