30,101 results match your criteria Hyperparathyroidism


Evaluation of endothelial function and diastolic function in patients with primary hyperparathyroidism before and after parathyroidectomy.

Cir Cir 2019 ;87(2):196-204

Unidad de Investigación en Endocrinología Experimental. Hospital de Especialidades Centro Médico Nacional Siglo XXI. Ciudad de México, México.

Introduction: Primary hyperparathyroidism (PHPT) is the leading cause of outpatient hypercalcemia associated with increased cardiovascular risk. The flow-mediated vasodilation (FMV) has been proposed as a non-invasive method for assessing endothelial function.

Objective: To compare the endothelial dysfunction measured by FMV and diastolic dysfunction in patients with PHPT before and after parathyroidectomy. Read More

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http://dx.doi.org/10.24875/CIRU.18000520DOI Listing
January 2019

Hypercalcaemic Crisis Due to Primary Hyperparathyroidism: Report of Two Cases.

J Crit Care Med (Targu Mures) 2019 Jan 4;5(1):34-39. Epub 2019 Feb 4.

University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Romania.

Introduction: A hypercalcaemic crisis, also called para thyrotoxicosis, hyper parathyroid crisis or parathyroid storm, is a complication of primary hyperparathyroidism (PHPT) and an endocrinology emergency that can have dramatic or even fatal consequences if it is not recognised and treated in time.

Case Presentation: Two cases presented in the emergency department with critical hypercalcaemic symptoms and severe elevation of serum calcium and parathyroid hormone levels, consistent with a hypercalcaemic crisis. The first case, a 16-year-old female patient, had imaging data that highlighted a single right inferior parathyroid adenoma and a targeted surgical approach was used. Read More

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http://dx.doi.org/10.2478/jccm-2019-0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369571PMC
January 2019

The prevalence and anatomy of parathyroid glands: a meta-analysis with implications for parathyroid surgery.

Langenbecks Arch Surg 2019 Feb 14. Epub 2019 Feb 14.

International Evidence-Based Anatomy Working Group, 12 Kopernika St., 31-034, Kraków, Poland.

Purpose: The anatomy of parathyroid glands (PTG) is highly variable in the population. The aim of this study was to conduct a systematic analysis on the prevalence and location of PTG in healthy and hyperparathyroidism (HPT) patients.

Methods: An extensive search of the major electronic databases was conducted to identify all studies that reported relevant data on the number of PTG per patient and location of PTG. Read More

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http://dx.doi.org/10.1007/s00423-019-01751-8DOI Listing
February 2019
2.160 Impact Factor

Factors associated with glomerular filtration rate variation in primary hyperparathyroidism after parathyroidectomy

Turk J Med Sci 2019 Feb 11;49(1):295-300. Epub 2019 Feb 11.

Background/aim: Prolonged hypercalcemia impairs renal function, and a reduced glomerular filtration rate (GFR) is typical in advanced primary hyperparathyroidism (PHPT). There are scarce data related to predictors of renal impairment in patients with PHPT. Hence, we aimed to evaluate changes in kidney function in PHPT patients after parathyroidectomy (PTX) and identify factors associated with GFR variation in these patients. Read More

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http://dx.doi.org/10.3906/sag-1806-181DOI Listing
February 2019

A novel interplay between irisin and PTH: from basic studies to clinical evidence in hyperparathyroidism.

J Clin Endocrinol Metab 2019 Feb 13. Epub 2019 Feb 13.

Department of Emergency and Organ Transplantation, University of Bari, Italy.

Context: Irisin is a hormone like-molecule that is cleaved and secreted by an unknown protease from fibronectin type III domain-containing protein 5 (FNDC5) and it ameliorates bone status, muscle atrophy and influences energy homeostasis. PTH exerts several metabolic effects that may interact with irisin's ones.

Objectives: To test the hypothesis that irisin and PTH mutually affect their biological action, we evaluated the FNDC5 mRNA and protein expression in myotubes treated with PTH (1-34) and PTH-r mRNA expression in osteoblasts treated with rec-irisin. Read More

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http://dx.doi.org/10.1210/jc.2018-02216DOI Listing
February 2019

[Intraoperative fluorescence angiography in primary hyperparathyroidism].

Authors:
H Dralle

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Sektion Endokrine Chirurgie, Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0907-3DOI Listing
February 2019

[Is autotransplantation with parathyroidectomy for secondary hyperparathyroidism outdated?]

Authors:
H Dralle

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Sektion Endokrine Chirurgie, Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0831-6DOI Listing
February 2019

[Secondary hyperparathyroidism after gastric bypass].

Authors:
H Dralle

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Sektion Endokrine Chirurgie, Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0839-yDOI Listing
February 2019

[Correction of secondary hyperparathyroidism with paricalcitol in renal transplant improves left ventricular hypertrophy].

G Ital Nefrol 2019 Feb;36(1)

Centro di Riferimento di Nefrologia e Dialisi, Ospedale Belcolle, Viterbo.

Background: Left ventricular hypertrophy (LVH) is common in renal transplant recipients (RTRs), and persistent secondary hyperparathyroidism (SHPT) is considered to be one of the main causes of its pathogenesis. In this study we evaluated if the control of SHPT with paricalcitol is associated with a reduction of LVH in RTRs.

Methods: For this purpose we selected 24 RTRs with LVH and SHPT. Read More

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February 2019

Bridging adults and paediatrics with secondary hyperparathyroidism receiving haemodialysis: a pharmacokinetic-pharmacodynamic analysis of cinacalcet.

Br J Clin Pharmacol 2019 Feb 12. Epub 2019 Feb 12.

Amgen, Inc., Thousand Oaks, CA, USA.

Aims: To develop a pharmacokinetic (PK) and PK-pharmacodynamic (PK/PD) model of cinacalcet, in adults and paediatrics with secondary hyperparathyroidism (SHPT) on dialysis. To test covariates of interest, and to perform simulations to inform dosing in paediatrics with SHPT.

Methods: Cinacalcet PK, intact parathyroid hormone (iPTH) and corrected calcium (cCa) time courses following multiple daily oral doses (1-300 mg) were modelled using a nonlinear mixed effects modelling approach using data from 8 clinical studies. Read More

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http://dx.doi.org/10.1111/bcp.13900DOI Listing
February 2019

Ectopic Parathyroid Adenoma: Surgical Correction and its Complication Management.

Mymensingh Med J 2019 Jan;28(1):245-249

Dr Mohammad Samir Azam Sunny, Medical Officer, Department of Cardiac Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh; E-mail:

Ectopic parathyroid are most frequently found in the anterior mediastinum, in association with the thymus or the thyroid gland. Ectopic parathyroid glands are a major cause of persistent and recurrent Hyperparathyroidism. We report a case of 65-year-old female was referred from Surgical Endocrine department to the department of Cardiac Surgery on 20 September, 2017 in Bangabandhu Sheikh Mujib Medical University with parathyroid crisis due to an ectopic mediastinal parathyroid adenoma with her serum calcium and PTH markedly increased in short time. Read More

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January 2019

A Familial Case of a Whole Germline CDC73 Deletion Discordant for Primary Hyperparathyroidism.

Horm Res Paediatr 2019 Feb 8:1-8. Epub 2019 Feb 8.

Department of Pediatrics, National Hospital Organization Tokyo Medical Center, Tokyo,

Introduction: Primary hyperparathyroidism (PHPT) occurs as part of familial syndromes, including CDC73-related disorders caused by germline pathogenic variants of the CDC73 gene, particularly in early adulthood. Herein, we report a familial case of a whole germline CDC73 deletion discordant for PHPT.

Case Description: A 15-year-old boy was admitted to our hospital because of persistent nausea and vomiting. Read More

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http://dx.doi.org/10.1159/000495800DOI Listing
February 2019
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Update of the role of Nuclear Medicine techniques in the pre-surgical localization of primary hyperparathyroidism.

Rev Esp Med Nucl Imagen Mol 2019 Feb 6. Epub 2019 Feb 6.

Servicio de Medicina Nuclear, Hospital Clínico Universitario de Salamanca, Salamanca, España.

Primary hyperparathyroidism is one of the most frequent endocrine disorders. Its diagnosis is biochemical. Imaging techniques are not useful for the diagnosis of this pathology; they are just tools for pre-surgical localization. Read More

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http://dx.doi.org/10.1016/j.remn.2018.12.007DOI Listing
February 2019
1 Read

Effects of parathyroidectomy on the biology of bone tissue in patients with chronic kidney disease and secondary hyperparathyroidism.

Bone 2019 Feb 6;121:277-283. Epub 2019 Feb 6.

LIM 16 - Laboratorio de Fisiopatologia Renal, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Hospital Samaritano Americas Serviços Medicos, Sao Paulo, SP, Brazil. Electronic address:

Secondary hyperparathyroidism is a complication of chronic kidney disease that compromises skeletal integrity. In patients with secondary hyperparathyroidism undergoing parathyroidectomy, parathyroid hormone levels dramatically decrease. The effects of parathyroidectomy on bone tissue are poorly understood, especially regarding the proteins expressed by osteocytes, such as fibroblast growth factor 23, dentin matrix protein 1, matrix extracellular phosphoglycoprotein, sclerostin, receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin, which regulate bone turnover. Read More

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http://dx.doi.org/10.1016/j.bone.2019.01.029DOI Listing
February 2019
1 Read

Autofluorescence in Parathyroidectomy: Signal Intensity Correlates with Serum Calcium and Parathyroid Hormone but Routine Clinical Use is Not Justified.

World J Surg 2019 Feb 8. Epub 2019 Feb 8.

Department of Endocrine Surgery, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK.

Background: The inability to identify the pathological gland at surgery results in failure to cure hyperparathyroidism in 2-5%. The poorly understood characteristic of parathyroid tissue to manifest autofluorescence (AF) under near-infrared (NIR) light has been promoted as an intraoperative adjunct in parathyroid surgery. This study sought to explore potential clinical correlates for AF and assess the clinical utility of AF in parathyroid surgery. Read More

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http://dx.doi.org/10.1007/s00268-019-04929-9DOI Listing
February 2019
2 Reads

Calciotropic Hormones and the Prevalence of Vertebral Fractures in Chinese Postmenopausal Women with Vitamin D Insufficiency: Peking Vertebral Fracture Study.

Calcif Tissue Int 2019 Feb 8. Epub 2019 Feb 8.

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, National Commission of Health, Chinese Academy of Medical Science, No. 1 Shuaifuyuan, Wangfujing Street, Dongcheng District, Beijing, 100730, China.

This case-control study aimed to examine the effect of high serum parathyroid hormone (PTH) level, especially the effect of secondary hyperparathyroidism (SHPT) related to hypovitaminosis D, on bone metabolism and bone phenotypes. We included a total of 830 Chinese postmenopausal women aged ≥ 50 years with serum 25-hydroxyvitamin D (25(OH)D) level < 30 ng/ml, among whom 415 women had prevalent vertebral fractures (VFs) and others were age-matched controls. We measured serum levels of 25(OH)D, PTH and bone turnover markers (BTMs), which included C-terminal telopeptide of type I collagen (β-CTX), N-aminoterminal prepeptide of type I procollagen (P1NP) and osteocalcin (OC). Read More

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http://dx.doi.org/10.1007/s00223-019-00531-2DOI Listing
February 2019
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Acute Kidney Injury Secondary to Hypercalcemia in a Kidney Transplant Patient With Pneumocystis jirovecii Pneumonia: A Case Report.

Transplant Proc 2019 Jan - Feb;51(1):220-222. Epub 2018 Jun 30.

Renal Transplant Unit, AO Brotzu, Cagliari, Italy.

Background: Persistent hyperparathyroidism is one of the main causes of hypercalcemia following kidney transplantation; differential diagnosis is required.

Case Presentation: We report the case of a 61-year-old kidney transplant recipient who underwent transplant in September 2016. She was admitted in March 2017 presenting with a 3-week history of asthenia, hypotension, and cough. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.077DOI Listing
June 2018
1 Read

Cinacalcet therapy in an infant with an R185Q calcium-sensing receptor mutation causing hyperparathyroidism: a case report and review of the literature.

J Pediatr Endocrinol Metab 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics, Division of Pediatric Endocrinology, Stanford University School of Medicine, Stanford, CA, USA.

Background Neonatal severe hyperparathyroidism (NSHPT) is commonly treated with either parathyroidectomy or pharmacologic agents with varying efficacy and numerous side effects. Reports of using cinacalcet for NSHPT have increased, however, the effective dose for pediatric patients from the onset of symptoms through infancy has not been established. Case presentation We describe the clinical course of a newborn with a de novo R185Q mutation in the calcium-sensing receptor (CASR) gene, causing NSHPT. Read More

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http://dx.doi.org/10.1515/jpem-2018-0307DOI Listing
February 2019
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Parathyroidectomy versus cinacalcet for tertiary hyperparathyroidism; a retrospective analysis.

Langenbecks Arch Surg 2019 Feb 7. Epub 2019 Feb 7.

Department of Surgery, Erasmus MC, University Medical Center Rotterdam, 's-Gravendijkwal 230, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.

Introduction: Tertiary hyperparathyroidism (tHPT), i.e., persistent HPT after kidney transplantation, affects 17-50% of transplant recipients. Read More

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http://dx.doi.org/10.1007/s00423-019-01755-4DOI Listing
February 2019
1 Read

Silicone-Induced Granulomatous Reaction Causing Severe Hypercalcemia: Case Report and Literature Review.

Case Rep Nephrol 2019 8;2019:9126172. Epub 2019 Jan 8.

Department of Internal Medicine, St. Elizabeth Health Center, Youngstown, Ohio, USA.

A 67-year-old woman presented to the hospital with complaints of abdominal pain. Physical exam was significant for signs of severe dehydration, mild epigastric tenderness and multiple non-tender hard nodules over her arms and thighs. Incidental finding of severe hypercalcemia led to negative workups for hyperparathyroidism, vitamin D intoxication, and malignancy. Read More

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http://dx.doi.org/10.1155/2019/9126172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341244PMC
January 2019
1 Read

[Erratum to: Diagnostics and treatment of primary hyperparathyroidism].

Authors:
C Nies

Chirurg 2019 Feb 6. Epub 2019 Feb 6.

Klinik für Allgemein- und Viszeralchirurgie, Niels-Stensen-Kliniken, Marienhospital Osnabrück, Bischofsstr. 1, 49074, Osnabrück, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0810-yDOI Listing
February 2019

Uremic lion face syndrome.

J Bras Nefrol 2019 Jan 21. Epub 2019 Jan 21.

Centro Hospitalar Lisboa Norte EPE, Serviço de Nefrologia e Transplantação Renal, Lisboa, Portugal.

Mineral bone disorder is a common feature of chronic kidney disease. Lion face syndrome is rare complication of severe hyperparathyroidism in end-stage renal disease patients, which has been less commonly reported due to dialysis and medical treatment advances in the last decade. The early recognition of the characteristic facial deformity is crucial to prompt management and prevent severe disfigurement. Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2018-0198DOI Listing
January 2019
1 Read

PRE-OPERATIVE LOCALIZATION OF PARATHYROID ADENOMA: PERFORMANCE OF 4D MRI PARATHYROID PROTOCOL.

Endocr Pract 2019 Jan 18. Epub 2019 Jan 18.

From: 1Department of Surgery, University of Arizona Medical Center.

Introduction: Accurate pre-operative image localization is critical in selection of minimally invasive parathyroidectomy (MIP) as a surgical treatment approach in patients with primary hyperparathyroidism (PHPT). Sestamibi scan, ultrasound, computed tomography and conventional magnetic resonance imaging (MRI) has varying accuracy in localizing parathyroid adenoma. Our group had previously shown that 4D MRI is more accurate than conventional imaging in identifying single adenomas. Read More

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http://dx.doi.org/10.4158/EP-2018-0424DOI Listing
January 2019
1 Read

BIOCHEMICAL DYNAMICS OF UNTREATED PRIMARY HYPERPARATHYROIDISM: AN OBSERVATIONAL STUDY.

Endocr Pract 2019 Jan 18. Epub 2019 Jan 18.

Department of Surgery, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA.

Objective: The natural biochemical history of untreated primary hyperparathyroidism (PHPT) is poorly understood. The purpose of this study was to determine the extent of biochemical fluctuations in patients with PHPT.

Design: Retrospective cohort study from January 1, 1995 to December 31, 2014. Read More

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http://dx.doi.org/10.4158/EP-2018-0489DOI Listing
January 2019
2 Reads

Effects of Long-Term Cinacalcet Administration on Parathyroid Gland in Hemodialysis Patients with Secondary Hyperparathyroidism.

Nephron 2019 Feb 1:1-8. Epub 2019 Feb 1.

Kidney Center, Shirasagi Hospital, Osaka, Japan.

Background/aim: Cinacalcet, an allosteric modulator of the calcium (Ca) sensing receptor, reduces the level of parathyroid hormone (PTH) in serum as well as parathyroid gland volume following administration in hemodialysis patients with secondary hyperparathyroidism, though long-term results are yet to be reported.

Methods: Serum parameters (n = 23), together with total parathyroid gland volume (n = 18), were determined in Japanese hemodialysis patients given cinacalcet treatment for 8 years.

Results: Following initiation of cinacalcet therapy, levels of serum Ca, phosphate, and intact PTH were significantly decreased. Read More

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http://dx.doi.org/10.1159/000496808DOI Listing
February 2019
1 Read

Comparison of hyperparathyroidism types and utility of dual radiopharmaceutical acquisition with Tc99m sestamibi and I for localization of rapid washout parathyroid adenomas.

Osteoporos Int 2019 Jan 31. Epub 2019 Jan 31.

Division of Nuclear Medicine, MedStar Washington Hospital Center, 110 Irving Street, NW, Suite GB1, Washington, DC, 20010, USA.

Tc99m-sestamibi dual-time imaging is a standard tool for localization of adenomas/hyperplasia in hyperparathyroidism. We investigated the degree and causes of localization failure among different types of hyperparathyroidism. Pre-operative parathyroid hormone levels and size of the gland were major determinants of Tc99m-sestamibi positivity; I scan may be helpful in localization failures. Read More

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http://dx.doi.org/10.1007/s00198-019-04846-6DOI Listing
January 2019

Diagnostic pitfalls in a cystic ectopic intrathyroidal parathyroid adenoma mimicking a nodular goiter: A care-compliant case report.

Medicine (Baltimore) 2019 Feb;98(5):e14351

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Rationale: Cystic parathyroid adenomas are rare and seldom arise in ectopically located glands which may be found within the carotid sheath, mediastinum, thymus, or thyroid grand. They cannot be detected consistently by any imaging methods. Unusual symptoms may bring about certain pitfalls and difficulties for the diagnosis of primary hyperparathyroidism (PHPT) caused by cystic parathyroid adenomas. Read More

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http://dx.doi.org/10.1097/MD.0000000000014351DOI Listing
February 2019
2 Reads

Fibroblast growth factor-23 (FGF-23) / soluble Klotho protein (sKlotho) / sclerostin glycoprotein ratio disturbance is a novel risk factor for cardiovascular complications in ESRD patients receiving treatment with regular hemodialysis or hemodiafiltration.

Ter Arkh 2018 Jun;90(6):48-54

I.M. Sechenov First Moscow State Medical University, Ministry of Health (Sechenov University), Moscow, Russia.

Aim: Aim of the study was to explore the role of the FGF-23/sKlotho/sclerostin ratio disturbance in the determining of cardiovascular risk in end stage renal disease (ESRD) patients, receiving treatment with regular hemodialysis (НD) or hemodiafiltration (НDF) online in Russia.

Materials And Methods: 42 patients with ESRD, at the age of 18-55 years, treated with HD or HDF on line for at least 6 months, were examined. 22 (52. Read More

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http://dx.doi.org/10.26442/terarkh201890648-54DOI Listing
June 2018
2 Reads

Computed tomography diagnosis of primary hyperparathyroidism.

Ter Arkh 2018 Apr;90(4):60-66

Russian Federal State Endocrinology Research Centre, Ministry of Health of Russia, Moscow, Russia.

The article presents data on modern approaches to the diagnosis of various manifestations of hyperparathyroidism according to multispiral computed tomography, which do not require morphological verification and ensure the correctness of the diagnostic process. The radiological picture and differential diagnostics of changes from parathyroid glands and bone structures at hyperparathyroidism are described in detail. Read More

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http://dx.doi.org/10.26442/terarkh201890460-66DOI Listing
April 2018
1 Read

Reproductive disorders, osteoporosis and secondary hyperparathyroidism with celiac disease.

Ter Arkh 2018 Nov;90(10):89-93

A.S. Loginov Moscow Clinical Scientific Practical Center of the Moscow Healthcare Department, Moscow, Russia.

A clinical observation of a patient with celiac disease, aged 23, with severe form of osteoporosis, accompanied by atraumatic fractures bones, lameness, late onset of menstruation and pathology of pregnancy is described. It is emphasized that only a timely diagnosis celiac disease and timely prescribed treatment make it possible to avoid severe complications. Read More

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http://dx.doi.org/10.26442/terarkh2018901089-93DOI Listing
November 2018
4 Reads

Primary hyperparathyroidism clinical features on endocrinology in-patients clinic.

Authors:
I E Sapozhnikova

Ter Arkh 2018 Nov;90(10):51-54

Kirov State Medical University, the Ministry of Health of the Russia, Kirov, Russia.

Aim: The analysis clinical features of primary hyperparathyroidism on endocrinology in-patients clinic.

Materials And Methods: Open retrospective study, included data of patients who were hospitalized at Kirov Regional Hospital with primary hyperparathyroidism from January 01, 2013 to December 31, 2016.

Results: 23 patients were hospitalized. Read More

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http://dx.doi.org/10.26442/terarkh2018901051-54DOI Listing
November 2018
1 Read

Sodium thiosulfate and pamidronate for treatment of calciphylaxis: case report.

Colomb Med (Cali) 2018 Dec 30;49(4):288-291. Epub 2018 Dec 30.

Complejo Asistencial Universitario de León, Servicio de Nefrología, León, España.

Introduction: Calciphylaxis is an infrequent disease that almost exclusively affects patients with chronic kidney disease, although cases have been observed in patients without renal function impairment. The diagnosis is mainly made by clinical manifestations and subsequently confirmed by radiological and histological study. The optimal treatment is not known, although there is a consensus that a multifactorial approach is required. Read More

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http://dx.doi.org/10.25100/cm.v49i3.4134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342083PMC
December 2018
6 Reads

Improved Control of Secondary Hyperparathyroidism in Hemodialysis Patients Switching from Oral Cinacalcet to Intravenous Etelcalcetide, Especially in Nonadherent Patients.

Blood Purif 2019 Jan 30:1-9. Epub 2019 Jan 30.

Department of Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, Barcelona,

Background: Etelcalcetide is a novel second-generation calcimimetic that, because of its intravenous administration, could improve treatment adherence in secondary hyperparathyroidism (SHPT). The aim of this study was to evaluate the effectiveness of etelcalcetide compared with that of cinacalcet in controlling SHPT in patients under hemodialysis.

Methods: A prospective observational study was performed in 29 patients with SHPT under hemodialysis who switched from cinacalcet to etelcalcetide with a follow-up of 6 months. Read More

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http://dx.doi.org/10.1159/000496562DOI Listing
January 2019
1 Read

Dwarfs and Giants of Parathyroid Adenomas-No Difference in Outcome After Parathyroidectomy.

J Surg Res 2019 Jan 25;237:56-60. Epub 2019 Jan 25.

Department of Endocrine Surgery, Churchill Cancer Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Backgroud: This study compares the outcome of parathyroidectomy for primary hyperparathyroidism (PHPT) in patients whose adenomas' weights were at the extremes of the distribution curve. As the size of parathyroid adenomas influences the success rate of localization studies for PHPT, it is possible that a difference in cure rate could be observed between subgroups of patients.

Materials And Methods: Data were retrieved from a prospective database maintained in a large university hospital. Read More

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http://dx.doi.org/10.1016/j.jss.2018.12.021DOI Listing
January 2019
1 Read

Potential Utility of Contrast-Enhanced Ultrasound in the Preoperative Evaluation of Primary Hyperparathyroidism.

J Ultrasound Med 2019 Jan 29. Epub 2019 Jan 29.

Departments of Endocrinology, La Paz University Hospital, Madrid, Spain.

Objectives: We aimed to compare the effectiveness of contrast-enhanced ultrasound (CEUS), technetium Tc 99m methoxyisobutylisonitrile ( Tc-MIBI) single-photon emission computed tomographic (SPECT) scintigraphy, and high-resolution ultrasound (US) in the detection of a pathologic parathyroid gland in patients with primary hyperparathyroidism (pHPT).

Methods: Twenty-nine consecutive patients with pHPT were prospectively enrolled and underwent preoperative imaging with Tc-MIBI SPECT scintigraphy, high-resolution US, and CEUS and subsequent parathyroidectomy. Contrast-enhanced US examinations were performed by an experienced examiner who was blinded to the results of scintigraphy and high-resolution US. Read More

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http://doi.wiley.com/10.1002/jum.14949
Publisher Site
http://dx.doi.org/10.1002/jum.14949DOI Listing
January 2019
2 Reads

Chronic kidney disease is associated with low BMD at the hip but not at the spine.

Osteoporos Int 2019 Jan 28. Epub 2019 Jan 28.

Nephrology Service, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Rua Dr. Enéas de Carvalho Aguiar 255, 7° andar, São Paulo, SP, 05403-000, Brazil.

Although chronic kidney disease is associated with other bone disorders, osteoporosis can be found in this context, and it is defined based on bone mineral density (BMD), measured by dual-energy X-ray absorptiometry. As CKD progresses, the percentage of normal BMD decreases, whereas that of osteopenia/osteoporosis increases, mostly due to hip involvement, particularly in patients with reduced renal function.

Introduction: Osteoporosis is a highly prevalent disease in patients with chronic kidney disease (CKD). Read More

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http://dx.doi.org/10.1007/s00198-019-04864-4DOI Listing
January 2019
2 Reads

Additional 20-Minute Intraoperative Parathormone Measurement Can Minimize Unnecessary Bilateral Neck Exploration.

J Surg Res 2019 Mar 1;235:264-269. Epub 2018 Nov 1.

Division of Endocrine Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida.

Background: Parathyroidectomy guided by intraoperative parathormone (ioPTH) monitoring for primary hyperparathyroidism (pHPT) confirms removal of all hyperfunctioning parathyroid glands. This study evaluates the utility of an additional 20-min ioPTH measurement in patients who fail to meet the >50% ioPTH drop criterion.

Methods: A retrospective review of prospectively collected data of 706 patients with pHPT who underwent parathyroidectomy guided by ioPTH monitoring was performed. Read More

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http://dx.doi.org/10.1016/j.jss.2018.08.043DOI Listing
March 2019
1 Read

The Effect of Short-Term Vitamin D Supplementation on Calcium Status in Vitamin D Insufficient Renal Transplant Recipients at Risk of Hypercalcemia.

J Ren Nutr 2019 Jan 25. Epub 2019 Jan 25.

Department of Renal Medicine, Cork University Hospital, Cork, Ireland; HRB Clinical Research Facility, University College Cork, Cork, Ireland.

Objective: Vitamin D insufficiency is highly prevalent among renal transplant recipients and in observational studies is associated with adverse outcomes. Hypercalcemia, usually due to persistent hyperparathyroidism, also commonly occurs in this population and often coexists with vitamin D insufficiency. However, concern that vitamin D supplementation might exacerbate the pre-existing hypercalcemia often leads clinicians to avoid vitamin D supplementation in such patients. Read More

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http://dx.doi.org/10.1053/j.jrn.2018.11.012DOI Listing
January 2019
1 Read

Recurrent tertiary hyperparathyroidism due to supernumerary parathyroid glands in a patient receiving long-term hemodialysis: a case report.

BMC Endocr Disord 2019 Jan 28;19(1):16. Epub 2019 Jan 28.

Department of Pathology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, 539 Chung Hsiao Rd, Chiayi, 600, Taiwan.

Background: Renal hyperparathyroidism is a common complication of chronic kidney disease (CKD) or end-stage renal disease (ESRD) characterized by elevated parathyroid hormone levels secondary to derangements in the homeostasis of calcium, phosphate, and vitamin D. Rapid correction of severe and prolonged hyperparathyroidism by surgical parathyroidectomy in long-term hemodialysis patients occasionally causes hungry bone syndrome. These patients then exhibit severe and long-lasting secondary or tertiary hyperparathyroidism with high bone turnover. Read More

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http://dx.doi.org/10.1186/s12902-019-0346-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350335PMC
January 2019
1 Read

Parathyroid-targeted overexpression of Regulator of G-Protein Signaling 5 (R GS5) causes hyperparathyroidism in transgenic mice.

J Bone Miner Res 2019 Jan 28. Epub 2019 Jan 28.

Division of General and Oncologic Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, 21201.

The relationship between impaired calcium sensing, dysregulated parathyroid hormone (PTH) secretion, and parathyroid cell proliferation in parathyroid neoplasia is not understood. We previously reported that a GTPase activating protein, regulator of G-protein signaling 5 (RGS5) is overexpressed in a subset of parathyroid tumors associated with primary hyperparathyroidism (PHPT), and that RGS5 can inhibit signaling from the calcium-sensing receptor (CASR). In vivo, we found that RGS5-null mice have abnormally low PTH levels. Read More

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http://dx.doi.org/10.1002/jbmr.3674DOI Listing
January 2019
2 Reads

Peritoneal dialysis can alleviate the clinical course of hungry bone syndrome after parathyroidectomy in dialysis patients with secondary hyperparathyroidism.

Int Urol Nephrol 2019 Jan 28. Epub 2019 Jan 28.

Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, 300# Guangzhou Road, Nanjing, 210029, Jiangsu Province, China.

Purpose: It is unclear whether clinical courses of hungry bone syndrome (HBS) after parathyroidectomy (PTX) in peritoneal dialysis (PD) and hemodialysis (HD) patients are different. The present study aimed to investigate the possible differences of postoperative hypocalcemia and hyperkalemia between PD and HD patients.

Methods: We performed retrospectively 29 PD patients as the PD group and 169 HD patients as the HD group undergoing successful total PTX with autotransplantation. Read More

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http://dx.doi.org/10.1007/s11255-019-02076-7DOI Listing
January 2019
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The role of combined techniques of scintigraphy and SPECT/CT in the diagnosis of primary hyperparathyroidism: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14154

"Lucian Blaga" University of Sibiu, Romania.

Rationale: Primary hyperparathyroidism, usually as a result of a hyperfunctioning parathyroid gland, represents more than 90% cases of patients evaluated for hypercalcemia. Combined techniques of preoperative scintigraphy and SPECT/CT serve as a successful minimally-invasive parathyroidectomy. This recent imaging method provides four-dimensional functional images with advanced contrast resolution which greatly facilitates preoperative localization of parathyroid adenomas. Read More

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http://dx.doi.org/10.1097/MD.0000000000014154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358356PMC
January 2019
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Does Primary Hyperparathyroidism Have an Association with Thyroid Papillary Cancer? A Retrospective Cohort Study.

World J Surg 2019 Jan 24. Epub 2019 Jan 24.

Department of General Surgery, University of Health Sciences, Kartal Dr. Lutfi Kirdar Training and Research Hospital, 34890, Istanbul, Turkey.

Background: To investigate the relationship between primary hyperparathyroidism (pHPT) and papillary thyroid cancer (PTC).

Methods: The perioperative findings of 275 patients with pHPT who underwent surgery between January 2014 and December 2017 were retrospectively reviewed. Thirty-one patients were diagnosed with pHPT and PTC concurrently. Read More

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http://dx.doi.org/10.1007/s00268-019-04920-4DOI Listing
January 2019
1 Read
2.642 Impact Factor

[Role of AGEs-RAGE system in CKD-MBD.]

Clin Calcium 2019 ;29(2):193-198

Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan.

Abnormalities, such as hyperparathyroidism, vascular calcification, and osteoporosis, are devastating complications in patients with end-stage renal disease(ESRD). These abnormalities significantly affect the quality of life and prognosis. Therefore, controlling the abnormalities of chronic kidney disease-mineral and bone metabolism play an important role in these patients. Read More

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http://dx.doi.org/10.20837/4201902193DOI Listing
January 2019
2 Reads

Bilateral Neck Exploration for Sporadic Primary Hyperparathyroidism: Utilization Patterns in 5,597 Patients Undergoing Parathyroidectomy in the Collaborative Endocrine Surgery Quality Improvement Program.

J Am Coll Surg 2019 Jan 21. Epub 2019 Jan 21.

Department of Surgery Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University Medical Center, Nashville, TN. Electronic address:

Intro: For many surgeons, focused parathyroidectomy has become the preferred approach for the management of sporadic primary hyperparathyroidism (HPT). This study describes utilization patterns of bilateral neck exploration (BE) by endocrine surgeons participating in the Collaborate Endocrine Surgery Quality Improvement Program (CESQIP).

Methods: Using the CESQIP parathyroid dataset (2014-2017), utilization trends, demographic and clinical characteristics of patients undergoing BE vs. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2018.12.034DOI Listing
January 2019
2 Reads

US-guided microwave ablation for secondary hyperparathyroidism in patients after renal transplantation: a pilot study.

Int J Hyperthermia 2019 Jan 24:1-6. Epub 2019 Jan 24.

b Interventional Ultrasound Center , China-Japan Friendship Hospital , Beijing , China.

Objective: To assess the safety and efficacy of ultrasound-guided microwave ablation (MWA) in the treatment of patients who develop secondary hyperparathyroidism (SHPT) after renal transplantation (RT).

Methods: In total, nine patients, each with symptomatic SHPT caused by RT and at least one enlarged parathyroid gland, underwent MWA via hydrodissection. Intact parathyroid hormone (i-PTH), serum calcium, serum phosphorus, creatinine and blood urea nitrogen concentrations, before and after MWA, were assessed and compared. Read More

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http://dx.doi.org/10.1080/02656736.2019.1566580DOI Listing
January 2019
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Intraoperative Parathyroid Autofluorescence Detection in Patients with Primary Hyperparathyroidism.

Ann Surg Oncol 2019 Jan 23. Epub 2019 Jan 23.

Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Background: Intrinsic near-infrared (NIR) autofluorescence of the parathyroid gland may improve intraoperative gland identification without the need for contrast agent injection. Compared with patients undergoing surgery for thyroid disease, identification of pathologic parathyroid tissue in patients with hyperparathyroidism is essential. This study analyzed the utility of a novel real-time autofluorescence imaging system in patients with primary hyperparathyroidism enrolled in a prospective feasibility clinical trial. Read More

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http://dx.doi.org/10.1245/s10434-019-07161-wDOI Listing
January 2019

Fibroblast Growth Factor 23 Genotype and Cardiovascular Disease in Patients Undergoing Hemodialysis.

Am J Nephrol 2019 22;49(2):125-132. Epub 2019 Jan 22.

Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana,

Background: Elevated serum concentrations of fibroblast growth factor 23 (FGF23) are associated with cardiovascular mortality in patients with chronic kidney disease and those undergoing dialysis.

Objectives: We tested the hypotheses that polymorphisms in FGF23, its co-receptor alpha-klotho (KL), and/or FGF23 receptors (FGFR) are associated with cardiovascular events and/or mortality.

Methods: We used 1,494 DNA samples collected at baseline from the Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events Trial, in which patients were randomized to the calcimimetic cinacalcet or placebo for the treatment of secondary hyperparathyroidism. Read More

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http://dx.doi.org/10.1159/000496060DOI Listing
January 2019
3 Reads

Relationship of Vitamin D Deficiency and Intraoperative Parathyroid Hormone Elevation in Completion and Total Thyroidectomy.

Otolaryngol Head Neck Surg 2019 Jan 22:194599818825467. Epub 2019 Jan 22.

4 Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Objective: To quantify how frequently intraoperative parathyroid hormone levels increase during thyroid surgery and to explore a possible relationship between secondary hyperparathyroidism due to vitamin D deficiency and elevation in intraoperative parathyroid hormone.

Study Design: Case series with chart review.

Setting: Tertiary academic center. Read More

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http://dx.doi.org/10.1177/0194599818825467DOI Listing
January 2019
2 Reads
1.721 Impact Factor