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    1 OF 69

    CENTRAL DIABETES INSIPIDUS: CLINICAL CHARACTERISTICS AND LONG-TERM COURSE IN A LARGE COHORT OF ADULTS.
    Endocr Pract 2017 Feb 22. Epub 2017 Feb 22.
    From: 1Endocrine Institute, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
    Purpose Central diabetes insipidus (CDI) is a rare heterogeneous condition with various underlying causes. This study sought to increase the still-limited data on the clinical characteristics and long-term course in adults diagnosed with CDI. Methods Data on demographics, presentation, imaging findings, affected pituitary axes, treatment, and complications were collected retrospectively from the files of 70 adult patients with CDI followed at a referral endocrine clinic. Read More

    Zinc Toxicosis in a Boxer Dog Secondary to Ingestion of Holiday Garland.
    J Med Toxicol 2017 Feb 21. Epub 2017 Feb 21.
    New York State Animal Health Diagnostic Center, Ithaca, NY, 14853, USA.
    Introduction: Increased admissions occur in small animal veterinary emergency clinics during some holidays, and some of the increased caseload is due to ingestion of toxic substances. This report documents zinc toxicosis contributing to the death of a dog after ingestion of holiday tinsel garland.

    Case Study: A mature boxer dog presented with a 4-day history of vomiting and diarrhea. Read More

    Method of Hypertonic Saline Administration: Effects on Osmolality in Traumatic Brain Injury Patients.
    J Clin Neurosci 2017 Feb 15. Epub 2017 Feb 15.
    Department of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN 1211 21st Avenue South, 404 Medical Arts Building, Nashville, TN 37232, United States.; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN 1161 21st Ave. So., T4224 Medical Center North, Nashville, TN 37232, United States.
    Hypertonic saline (HTS) is an effective therapy for reducing intracranial pressure (ICP). The ideal method of administration is unknown. The purpose of this study was to evaluate the method of HTS infusion and time to goal osmolality. Read More

    A systematic review of known interventions for the treatment of chronic non-hypovolaemic hypotonic hyponatraemia and a meta-analysis of the vaptans.
    Clin Endocrinol (Oxf) 2017 Feb 18. Epub 2017 Feb 18.
    Health Economics & Outcomes Research, Otsuka Pharmaceutical Europe Ltd, UK.
    International and national guidelines on the treatment of chronic non-hypovolaemic hypotonic hyponatraemia differ; therefore we have undertaken this systematic review and meta-analysis to investigate the efficacy and safety of interventions for the treatment of chronic non-hypovolaemic hypotonic hyponatraemia. Following registration of the review protocol with PROSPERO, systematic literature searches were conducted to identify randomised and quasi-randomised controlled trials assessing any degree of fluid restriction or any drug treatment with the aim of increasing serum sodium concentration in patients with chronic non-hypovolaemic hypotonic hyponatraemia. Where appropriate, outcome data were synthesised in a meta-analysis. Read More

    The effect of nonpharmacological training on delirium identification and intervention strategies of intensive care nurses.
    Intensive Crit Care Nurs 2017 Feb 14. Epub 2017 Feb 14.
    Cumhuriyet University, Faculty of Health Sciences, Nursing Department, Sivas, Turkey. Electronic address:
    Objective: This study aims to investigate the effect of nonpharmacological intervention training on delirium recognition and the intervention strategies of intensive care (ICU) nurses.

    Method: This is a quasi-experimental study conducted using a pretest-posttest design. The study sample included a total of 95 patients staying in the medical ICU of a university hospital and 19 nurses working in these units. Read More

    [Hyponatremia and its etiology in pediatric patients admitted to the emergency room].
    Rev Med Inst Mex Seguro Soc 2017 ;55 Suppl 1:S64-S70
    Servicio de Cardiología Pediátrica, Hospital de Pediatría, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.
    Background: The importance of hyponatremia is underestimated despite it is a frequent alteration in a hospital environment. Usually no cause is investigated and it is treated as an isolated data. The aim was to determine the prevalence and etiology of hyponatremia in pediatric patients. Read More

    Hypernatremia in the Neonate: Neonatal Hypernatremia and Hypernatremic Dehydration in Neonates Receiving Exclusive Breastfeeding.
    Indian J Crit Care Med 2017 Jan;21(1):30-33
    Department of Paediatrics, Lata Mangeshkar Hospital, Hingna, Nagpur, Maharashtra, India.
    Aims And Objectives: Evaluation of neonatal hypernatremia and hypernatremic dehydration in neonates receiving exclusive breastfeeding.

    Introduction: Neonatal hypernatremia is a serious condition in the newborn period. We present infants with hypernatremic dehydration due to breast milk (BM) hypernatremia. Read More

    Neurologic manifestations of major electrolyte abnormalities.
    Handb Clin Neurol 2017 ;141:705-713
    Department of Neurology, Washington University, St. Louis, MO, USA. Electronic address:
    The brain operates in an extraordinarily intricate environment which demands precise regulation of electrolytes. Tight control over their concentrations and gradients across cellular compartments is essential and when these relationships are disturbed neurologic manifestations may develop. Perturbations of sodium are the electrolyte disturbances that most often lead to neurologic manifestations. Read More

    A case of central diabetes insipidus after ketamine infusion during an external to internal carotid artery bypass.
    J Clin Anesth 2017 Feb 25;36:72-75. Epub 2016 Nov 25.
    Department of Anesthesiology, Tulane Medical Center, New Orleans, LA, USA.
    Study Objective: We report the first teenage case of ketamine-induced transient central diabetes insipidus.

    Case Summary: The patient was an 18-year-old woman with moyamoya disease undergoing an external carotid to internal carotid bypass and given a low-dose ketamine infusion. After approximately 2 hours in the supine position, with 0. Read More

    A Quick Reference on Hypernatremia.
    Vet Clin North Am Small Anim Pract 2017 Mar;47(2):209-212
    Department of Veterinary Clinical Sciences, The Ohio State University, 601 Vernon L. Tharp Street, Columbus, OH 43210, USA.
    Hypernatremia most commonly is associated with water loss in excess of sodium or salt gain (typically associated with restriction of access to water). Most of the signs of hypernatremia arise from the central nervous system; the more rapid the development of hypernatremia, the more severe the neurologic signs are likely to be. Anorexia, lethargy, vomiting, muscular weakness, behavioral changes, disorientation, ataxia, seizures, coma, and death have been identified in dogs and cats with hypernatremia and hypertonicity. Read More

    Case Report: Severe hypernatremia from psychogenic adipsia.
    F1000Res 2017 11;6:34. Epub 2017 Jan 11.
    Division of Internal Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, USA.
    Hypernatremia is a common emergency room presentation and carries high mortality. We describe a case of a 56-year-old male patient with who presents with refusal to drink water for several weeks leading to the admission. He was diagnosed with psychogenic adipsia and was treated successfully with fluids, mirtazapine and clonazepam. Read More

    Complications in mechanically ventilated patients of Guillain-Barre syndrome and their prognostic value.
    J Neurosci Rural Pract 2017 Jan-Mar;8(1):68-73
    Department of Biostatistics, NIMHANS, Bengaluru, Karnataka, India.
    Introduction: The spectrum of various complications in critically ill Guillain-Barre syndrome (GBS) and its effect on the prognosis is lacking in literature. This study aimed at enumerating the complications in such a cohort and their significance in the prognosis and mortality.

    Materials And Methods: Retrospective case record analysis of all consecutive mechanically ventilated patients of GBS in neurology Intensive Care Unit (ICU) of a tertiary care institute for 10 years was done. Read More

    Metabolic toxicities in patients undergoing treatment for nonhematological malignancy: A cross-sectional study.
    Indian J Med Paediatr Oncol 2016 Oct-Dec;37(4):256-259
    Department of Radiation Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
    Objectives: The objective of this study was to evaluate the prevalence of metabolic toxicities in patients with different nonhematological malignancies admitted in oncology ward of a tertiary cancer care center while on treatment.

    Methods: We did this cross-sectional study over a period of 7 months (January-July 2013) for all adult patients (n = 280) who, while undergoing anti-cancer therapy at our center, got admitted to our oncology inpatient ward with metabolic toxicity. Grading of toxicity was done using National Cancer Institute Common Terminology Criteria for Adverse Events Version 4. Read More

    Reactivated cytomegalovirus proctitis in an immunocompetent patient presenting as nosocomial diarrhea: a case report and literature review.
    BMC Infect Dis 2017 Feb 1;17(1):113. Epub 2017 Feb 1.
    Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
    Background: Reactivated cytomegalovirus (CMV) infection has been known to cause significant morbidity and mortality in immunocompromised patients. However, CMV disease rarely develops in immunocompetent patients, and reported cases often present with a mild, self-limiting course, without severe life-threatening sequelae. While the colon is the most common gastrointestinal site affected by CMV disease in immunocompetent patients, rectal involvement is rarely reported. Read More

    [Extrapontine myelinolysis developed after aneurysmal subarachnoid hemorrhage (a case report and literature review)].
    Zh Vopr Neirokhir Im N N Burdenko 2016 ;80(6):82-87
    Polenov Russian Scientific Research Institute of Neurosurgery, the Branch of the Almazov Federal North-West Medical Research Centre, St. Petersburg, Russia.
    Topicality: Central pontine and extrapontine myelinolysis is a rare and dangerous form of the demyelinating process of undefined origin, the development of which is associated with a very low sodium level in the blood (hypernatremia).

    Objective: To describe a rare case of extrapontine myelinolysis as a complication occurring in the hemorrhagic period of anterior communicating artery aneurysm rupture as well as to demonstrate that this condition can be diagnosed intravitally.

    Conclusion: Clinical vigilance of extrapontine myelinolysis may promote the timely diagnosis and treatment of this disease, which is a potential cause of death. Read More

    Early oxytocin inhibition of salt intake after furosemide treatment in rats?
    Physiol Behav 2017 Jan 25;173:34-41. Epub 2017 Jan 25.
    Oklahoma State University - Center for Health Sciences, Tulsa, OK 74107, United States. Electronic address:
    Body fluid homeostasis requires a complex suite of physiological and behavioral processes. Understanding of the role of the central nervous system (CNS) in integrating these processes has been advanced by research employing immunohistochemical techniques to assess responses to a variety of body fluid challenges. Such techniques have revealed sex/estrogen differences in CNS activation in response to hypotension and hypernatremia. Read More

    Vasopressin Bolus Protocol Compared to Desmopressin (DDAVP) for Managing Acute, Postoperative Central Diabetes Insipidus and Hypovolemic Shock.
    Case Rep Endocrinol 2017 3;2017:3052102. Epub 2017 Jan 3.
    Department of Neurology, University of Missouri, Columbia, MO, USA.
    Introduction. Management of postoperative central diabetes insipidus (DI) can be challenging from changes in volume status and serum sodium levels. We report a case successfully using a dilute vasopressin bolus protocol in managing hypovolemic shock in acute, postoperative, central DI. Read More

    Consequences of Androctonus mauretanicus and Buthus occitanus scorpion venoms on electrolyte levels in rabbits.
    Heliyon 2017 Jan 5;3(1):e00221. Epub 2017 Jan 5.
    Laboratory of Venoms and Toxins, Pasteur Institute of Morocco, 1 Place Louis Pasteur, Casablanca, 20360, Morocco.
    Androctonus mauretanicus (A. mauretanicus) and Buthus occitanus (B. occitanus) scorpions, which belong to the Buthidae family, are the most venomous scorpions in Morocco. Read More

    Cerebral Salt Wasting Is the Most Common Cause of Hyponatremia in Stroke.
    J Stroke Cerebrovasc Dis 2017 Jan 16. Epub 2017 Jan 16.
    Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. Electronic address:
    Objective: The study aimed to evaluate the frequency, severity, and causes of hyponatremia in stroke and its influence on outcome.

    Materials And Methods: Consecutive computed tomography- or magnetic resonance imaging-proven stroke patients within 7 days of stroke were included. Severity of stroke was assessed using the National Institute of Health Stroke Scale and consciousness using the Glasgow Coma Scale. Read More

    Hypertonicity: Clinical entities, manifestations and treatment.
    World J Nephrol 2017 Jan;6(1):1-13
    Helbert Rondon-Berrios, Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, United States.
    Hypertonicity causes severe clinical manifestations and is associated with mortality and severe short-term and long-term neurological sequelae. The main clinical syndromes of hypertonicity are hypernatremia and hyperglycemia. Hypernatremia results from relative excess of body sodium over body water. Read More

    [Hypernatremia caused by treatment with GHB obtained via a doctor's prescription].
    Tijdschr Psychiatr 2017 ;59(1):47-51
    In the last few years, gamma hydroxybutyric acid (GHB) has been used increasingly as a party drug; this has led to a marked increase in the number of requests for professional help with the treatment of GHB addiction. Pharmaceutical GHB (sodium oxybate, the sodium-salt of GHB), registered for cataplexia in narcolepsy patients, is used off-label to treat the withdrawal symptoms associated with GHB addiction. Pharmaceutical GHB has a high sodium load. Read More

    Glucocorticoid-induced leucine zipper protein regulates sodium and potassium balance in the distal nephron.
    Kidney Int 2017 Jan 13. Epub 2017 Jan 13.
    Division of Nephrology, Department of Medicine, University of California, San Francisco, California, USA. Electronic address:
    Glucocorticoid induced leucine zipper protein (GILZ) is an aldosterone-regulated protein that controls sodium transport in cultured kidney epithelial cells. Mice lacking GILZ have been reported previously to have electrolyte abnormalities. However, the mechanistic basis has not been explored. Read More

    Adipsic diabetes insipidus in adult patients.
    Pituitary 2017 Jan 10. Epub 2017 Jan 10.
    Academic Department of Endocrinology, Beaumont Hospital/RCSI Medical School, Beaumont Road, Dublin 9, Co., Dublin, Ireland.
    Introduction: Adipsic diabetes insipidus (ADI) is a very rare disorder, characterized by hypotonic polyuria due to arginine vasopressin (AVP) deficiency and failure to generate the sensation of thirst in response to hypernatraemia. As the sensation of thirst is the key homeostatic mechanism that prevents hypernatraemic dehydration in patients with untreated diabetes insipidus (DI), adipsia leads to failure to respond to aquaresis with appropriate fluid intake. This predisposes to the development of significant hypernatraemia, which is the typical biochemical manifestation of adipsic DI. Read More

    Extra-pontine myelinolysis secondary to hypernatremia induced by postpartum water restriction.
    Neuroradiol J 2017 Feb 6;30(1):84-87. Epub 2017 Jan 6.
    2 Neurology Department, Max Superspeciality Hospital, Dehradun, India.
    A young adult female with restricted water intake during the postpartum period presented with history of progressive weakness, dizziness and tendency to fall with generalized slowing of movement. On examination, patient was anaemic, febrile and stuporous. Investigations revealed hypernatremia, delta waves in electroencephalogram (EEG) and features suggestive of extra-pontine myelinolysis on magnetic resonance imaging (MRI) of brain. Read More

    Disorders of Sodium and Water Homeostasis.
    Vet Clin North Am Small Anim Pract 2017 Mar 23;47(2):293-312. Epub 2016 Dec 23.
    Department of Veterinary Clinical Sciences, The Ohio State University, 601 Vernon L. Tharp Street, Columbus, OH 43210, USA.
    This review article discusses normal and abnormal sodium balance in small animals. The terms and concepts central to understanding normal sodium and water balance are presented as well as of the physiology of body fluid compartments and the movement of fluid between those compartments. As dysnatremia is a very common disorder across the spectrum of critically ill patients, the main focus of the article is to present several clinical examples of both acute and chronic hypernatremia and hyponatremia and their practical, clinical management. Read More

    [MODERN APPROACHES TO CORRECTION OF HYPERNATREMIA IN NEUROSURGICAL PATIENTS].
    Georgian Med News 2016 Nov(Issue):12-16
    Karaganda State Medical University, Kazakhstan.
    The article presents the analysis of the intensive therapy through the correction of persistent hypernatremia in neurosurgical patients after removal of brain tumors. The aim of this work was to evaluate the effectiveness of Sterofundin in the framework of complex therapy of hypernatremia in neurosurgical patients after removal of brain tumors. We analyzed the dynamics of the concentrations of sodium, potassium, chorus of the plasma, anion gap and buffer bases in the postoperative period of these patients. Read More

    Hydrochlorothiazide in intensive care unit-acquired hypernatremia: A randomized controlled trial.
    J Crit Care 2016 Dec 2;38:225-230. Epub 2016 Dec 2.
    Department of Intensive Care, Medical Centre Leeuwarden, PO Box 888, 8901 BK Leeuwarden, the Netherlands. Electronic address:
    Purpose: Thiazides are suggested as a treatment for intensive care unit (ICU)-acquired hypernatremia (IAH). The primary aim of the study was reducing serum sodium concentration (sNa) in patients with IAH with hydrochlorothiazide (HCT) in comparison to placebo. Secondary end points were a difference in urine sodium concentration (uNa) and duration of severe IAH. Read More

    Delayed recovery of adipsic diabetes insipidus (ADI) caused by elective clipping of anterior communicating artery and left middle cerebral artery aneurysms.
    N Z Med J 2016 Dec 16;129(1447):86-90. Epub 2016 Dec 16.
    Department of Neurosurgery, Beaumont Hospital, Dublin, Republic of Ireland.
    Adipsic diabetes insipidus (ADI) is an extremely rare complication following microsurgical clipping of anterior communicating artery aneurysm (ACoA) and left middle cerebral artery (MCA) aneurysm. It poses a significant challenge to manage due to an absent thirst response and the co-existence of cognitive impairment in our patient. Recovery from adipsic DI has hitherto been reported only once. Read More

    Cerebral Disorders of Calves.
    Vet Clin North Am Food Anim Pract 2017 Mar 8;33(1):27-41. Epub 2016 Dec 8.
    Department of Population Health & Pathobiology, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA. Electronic address:
    Neurologic diseases of the cerebrum are relatively common in cattle. In calves, the primary cerebral disorders are polioencephalomalacia, meningitis, and sodium toxicity. Because diagnostic testing is not always readily available, the practitioner must often decide on a course of treatment based on knowledge of the likely disease, as well as his or her own clinical experience. Read More

    Sodium supply influences plasma sodium concentration and the risks of hyper- and hyponatremia in extremely preterm infants.
    Pediatr Res 2017 Jan 18. Epub 2017 Jan 18.
    Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
    Background: Hyper- and hyponatremia occur frequently in extremely preterm infants. Our purpose was to investigate plasma sodium (P-Na) concentrations, the incidence of hyper- and hyponatremia, and the impact of possible predisposing factors in extremely preterm infants.

    Methods: In this observational study, we analyzed data from the EXtremely PREterm (< 27 wk. Read More

    Is Bicarbonate Therapy Useful?
    Vet Clin North Am Small Anim Pract 2017 Mar 18;47(2):343-349. Epub 2016 Nov 18.
    Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, Room 2112, Tupper Hall, Davis, CA 95616, USA. Electronic address:
    Despite concerns about the negative effects of metabolic acidosis, there is minimal evidence that sodium bicarbonate administration is an effective treatment. In addition, sodium bicarbonate therapy is associated with many adverse effects, including paradoxic intracellular acidosis, hypokalemia, hypocalcemia, hypernatremia, and hyperosmolality. Definitive recommendations regarding bicarbonate therapy are challenging as there is little high-quality evidence available. Read More

    The clinical predictors of shunt-dependent hydrocephalus following aneurysmal subarachnoid hemorrhage.
    Turk Neurosurg 2016 Oct 17. Epub 2016 Oct 17.
    YongHe Cardinal Tien Hospital.
    Aim: Shunt-dependent hydrocephalus (SDH) is a relatively common complication following aneurysmal subarachnoid hemorrhage (aSAH). Delay in diagnosis and treatment may worsen neurological outcome. This study was conducted to identify early clinical factors associated with SDH following aSAH. Read More

    Severe hypernatremia as a predictor of mortality after percutaneous endoscopic gastrostomy (PEG) placement.
    Dig Liver Dis 2017 Feb 2;49(2):181-187. Epub 2016 Nov 2.
    S. Orsola-Malpighi Hospital, Bologna, Department of Medical and Surgical Sciences-DIMEC, University of Bologna, Italy.
    Background: Percutaneous endoscopic gastrostomy is the preferred option for providing enteral nutrition, allowing for an improvement in survival and quality of life.

    Aim: To evaluate risk factors for early and delayed mortality after gastrostomy placement.

    Methods: A single-center retrospective analysis of a prospectively-collected database including all patients undergoing gastrostomy placement for enteral nutrition was performed. Read More

    Adverse effects of tempol on hidrosaline balance in rats with acute sodium overload.
    Biotech Histochem 2016 Nov;91(8):510-521
    a Cardiological Research Institute (ININCA), Scientific and Technological Research National Council (CONICET), University of Buenos Aires , Buenos Aires , Argentina.
    We studied the effects of tempol, an oxygen radical scavenger, on hydrosaline balance in rats with acute sodium overload. Male rats with free access to water were injected with isotonic (control group) or hypertonic saline solution (0.80 mol/l NaCl) either alone (Na group) or with tempol (Na-T group). Read More

    Lakartidningen 2016 Nov 14;113. Epub 2016 Nov 14.
    Danderyds Sjukhus - Anestesi och Intensivvård Stockholm, Sweden Danderyds Sjukhus - Anestesi och Intensivvård Stockholm, Sweden.
    Hypernatremia in ICU is common, both as a preexisting condition and acquired during intensive care. Hypernatremia increases mortality and morbidity as an increased length of a stay and increased risk of complications. Current treatment options of manifest hypernatremia are limited, but there are opportunities for prevention that should not be overlooked. Read More

    Hyponatremia is Associated with Fluid Imbalance and Adverse Renal Outcome in Chronic Kidney Disease Patients Treated with Diuretics.
    Sci Rep 2016 Nov 14;6:36817. Epub 2016 Nov 14.
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Chronic kidney disease (CKD) is frequently complicated with hyponatremia, probably because of fluid overload or diuretic usage. Hyponatremia in CKD population is associated with increased mortality, but the effect on renal outcome was unknown. We investigated whether hyponatremia is associated with fluid status and is a prognostic indicator for adverse outcomes in a CKD cohort of 4,766 patients with 1,009 diuretic users. Read More

    Acquired hypernatremia in a general surgical Intensive Care Unit: Incidence and prognosis.
    Saudi J Anaesth 2016 Oct-Dec;10(4):409-413
    Department of Nursing, College of Medicine, King Saud University, King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia.
    Purpose: Intensive Care Unit (ICU)-acquired hypernatremia (IAH) is a serious electrolyte disturbance that recently was shown to present an independent risk factor for mortality in critically ill patients. IAH has not been widely investigated in Surgical ICU (SICU) patients. No study has specifically investigated IAH epidemiology in the Kingdome of Saudi Arabia (KSA) in general SICU. Read More

    Clinical Associations of Early Dysnatremias in Critically Ill Neonates and Infants Undergoing Cardiac Surgery.
    Pediatr Cardiol 2017 Jan 8;38(1):149-154. Epub 2016 Nov 8.
    The Heart Institute, Department of Pediatrics, Children's Hospital Colorado, University of Colorado Denver School of Medicine, Aurora, CO, USA.
    Dysnatremias (DN) are common electrolyte disturbances in cardiac critical illness and are known risk factors for adverse outcomes in certain populations. Little information exists on DN in children with cardiac disease admitted to the cardiac intensive care unit (CICU) after undergoing cardiac surgery, either corrective or palliative. The aim was to determine the incidence and adverse outcomes associated with DN in neonates and infants undergoing cardiac surgery. Read More

    [Influence of preventive use of vasopressin tannate on diabetes insipidus and serum sodium at the early postoperation of craniopharyngioma].
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2016 Oct;41(10):1058-1063
    Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
    Objective: To explore the influence of preventive use of vasopressin tannate on diabetes insipidus and serum sodium at the early postoperation of craniopharyngioma.
 Methods: The data of 83 patients, who underwent unilateral sub-frontal approach resection of craniopharyngioma between 2010 and 2014 by the same senior neurosurgeon, were retrospectively analyzed. The patients were divided into a vasopressin tannate group (used group) and a control group. Read More

    [Extracorporeal membrane oxygenation for rescuing 12 children with acute fulminant myocarditis].
    Zhonghua Er Ke Za Zhi 2016 Nov;54(11):843-846
    Cardiopulmonary Bypass Department, Children's Hospital, Zhejiang University, Hangzhou 310000, China.
    Objective: To summarize clinical experience of using extracorporeal membrane oxygenation (ECMO) in rescuing children with acute fulminant myocarditis (AFM). Method: Data of 12 children with acute fulminate myocarditis (6 boys and 6 girls, median age 8.3 (0. Read More

    Sodium-chloride Difference and Metabolic Syndrome: A Population-based Large-scale Cohort Study.
    Intern Med 2016;55(21):3085-3090. Epub 2016 Nov 1.
    Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Japan.
    Objective Metabolic syndrome (MetS) is associated with cardiovascular disease, which is the leading cause of mortality and morbidity. Hypernatremia and hypochloremia are also associated with an increased mortality. Thus, the aim of this study was to evaluate the association between the sodium-chloride difference (Na(+)-Cl(-)) and MetS. Read More

    Does 2 L Polyethylene Glycol Plus Ascorbic Acid Increase the Risk of Renal Impairment Compared to 4 L Polyethylene Glycol?
    Dig Dis Sci 2016 Nov 13;61(11):3207-3214. Epub 2016 Sep 13.
    Department of Internal Medicine, Konkuk University School of Medicine, 120-1 Neungdong-ro, Gwangjin-gu, Seoul, 143-729, Korea.
    Background: The use of polyethylene glycol (PEG)-based solutions is the gold standard for bowel preparation. However, PEG use might be associated with the risk of acute kidney injury.

    Aims: We aimed to compare the safety of 2 L PEG plus ascorbic acid (AA) versus 4 L PEG. Read More

    Clinical Factors Predicting the Effect of Tolvaptan for Refractory Ascites in Patients with Decompensated Liver Cirrhosis.
    Dig Dis 2016;34(6):659-664. Epub 2016 Oct 17.
    Objective: Refractory ascites reduces the quality of life of liver cirrhosis patients. Albumin preparation and diuretics, such as furosemide, have been used to treat refractory ascites, but the effect was poor in many patients. In this study, we analyzed patients treated with tolvaptan (TLV) at our hospital and investigated predictors of the effect. Read More

    Transient Diabetes Insipidus After Discontinuation of Vasopressin in Neurological Intensive Care Unit Patients: Case Series and Literature Review.
    World Neurosurg 2017 Jan 11;97:479-488. Epub 2016 Oct 11.
    Department of Neurosurgery, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA. Electronic address:
    Background: Arginine vasopressin (AVP) is a common second-line or third-line vasopressor used in critically ill neurosurgical patients. Neurosurgical indications include hyperdynamic therapy for vasospasm, maintenance of cerebral perfusion pressure in patients with intracranial hypertension, and prevention of hypotension in patients with sepsis.

    Case Description: A series of 6 neurosurgical patients receiving AVP infusions developed severe but transient diabetes insipidus (tDI) after cessation of AVP. Read More

    Bendamustine-induced nephrogenic diabetes insipidus
.
    Clin Nephrol 2017 Jan;87 (2017)(1):47-50
    A 59-year-old man presented with polyuria and polydipsia immediately following his sixth cycle of rituximab and bendamustine for chronic lymphocytic leukemia. He initially compensated by increasing his oral fluid intake at home, but later developed septic shock and was admitted with orders to be kept nil per os (NPO). This prompted an episode of acute hypernatremia during which he exhibited continued polyuria with inappropriately dilute urine. Read More

    Extreme hypernatremia as a probable cause of fatal arrhythmia: a case report.
    J Med Case Rep 2016 Oct 1;10(1):272. Epub 2016 Oct 1.
    Department of Diabetes and Endocrinology, National Hospital of Sri Lanka, Colombo, Sri Lanka.
    Background: Hypernatremia is a frequent occurrence among hospitalized patients. Severe hypernatremia is associated with mortality rates of over 60 %. Extreme hypernatremia, defined as sodium levels >190 mmol/l, is a rare occurrence. Read More

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