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    3440 results match your criteria Hypernatremia

    1 OF 69

    Usefulness of anti-rabphilin-3A antibodies for diagnosing central diabetes insipidus in the third trimester of pregnancy.
    Endocr J 2017 Apr 14. Epub 2017 Apr 14.
    Department of Endocrinology and Applied Medical Science, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
    We report a 27-year-old pregnant woman with polyuria, polydipsia and headache in the third trimester of pregnancy. Hypernatremia (153 mEq/L), high plasma osmolality (300 mOsm/kgH2O) and low urinary osmolality (92 mOsm/kgH2O) were observed at the admission to our hospital. Plasma arginine vasopressin (AVP) level was inappropriately low (2. Read More

    Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis.
    Kidney Int 2017 Apr 3. Epub 2017 Apr 3.
    Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida, USA. Electronic address:
    The sodium/proton exchanger isoform 3 (NHE3) is expressed in the intestine and the kidney, where it facilitates sodium (re)absorption and proton secretion. The importance of NHE3 in the kidney for sodium chloride homeostasis, relative to the intestine, is unknown. Constitutive tubule-specific NHE3 knockout mice (NHE3(loxloxCre)) did not show significant differences compared to control mice in body weight, blood pH or bicarbonate and plasma sodium, potassium, or aldosterone levels. Read More

    Renal compensatory adaptation for water handling in a patient with adipsic diabetes insipidus after clipping of a ruptured aneurysm of the anterior communicating artery
    Clin Nephrol 2017 Apr 4. Epub 2017 Apr 4.
    A 38-year-old Japanese man who had undergone clipping surgery for a ruptured aneurysm of the anterior communicating artery 2 days prior, suddenly developed refractory hypernatremia (serum sodium (Na) 156 - 162 mmol/L). Symptoms included low plasma vasopressin, fluctuating urine osmolality (120 - 710 mOsm/kg) and lack of thirst, all suggesting adipsic diabetes insipidus (ADI). Hypernatremia was corrected by scheduled water intake with desmopressin administration. Read More

    NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality.
    J Am Soc Nephrol 2017 Mar 30. Epub 2017 Mar 30.
    Due to the number of contributing authors, the affiliations are listed in the supplemental material.
    Disorders of water balance, an excess or deficit of total body water relative to body electrolyte content, are common and ascertained by plasma hypo- or hypernatremia, respectively. We performed a two-stage genome-wide association study meta-analysis on plasma sodium concentration in 45,889 individuals of European descent (stage 1 discovery) and 17,637 additional individuals of European descent (stage 2 replication), and a transethnic meta-analysis of replicated single-nucleotide polymorphisms in 79,506 individuals (63,526 individuals of European descent, 8765 individuals of Asian Indian descent, and 7215 individuals of African descent). In stage 1, we identified eight loci associated with plasma sodium concentration at P<5. Read More

    Clinical characteristics of zinc phosphide poisoning in Thailand.
    Ther Clin Risk Manag 2017 14;13:335-340. Epub 2017 Mar 14.
    Ramathibodi Poison Center.
    Objective: The objectives of this study were to describe the clinical characteristics and outcomes of poisoning by zinc phosphide, a common rodenticide in Thailand, and to evaluate whether these outcomes can be prognosticated by the clinical presentation.

    Materials And Methods: A 3-year retrospective cohort study was performed using data from the Ramathibodi Poison Center Toxic Exposure Surveillance System.

    Results: In total, 455 poisonings were identified. Read More

    A Novel Practical Equation for Treatment of Emergent Hypernatremia and Dehydration Phase in Infants.
    J Res Pharm Pract 2017 Jan-Mar;6(1):56-59
    Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
    Serum sodium (Na) concentration more than 145 mmol/L is defined as hypernatremia. Hypernatremia carries an acute morbidity and mortality, especially in neonates and infants. Rapid correction of hypernatremia leads to severe cerebral damages, and seizure is the most common neurological complication of hypernatremia. Read More

    Long-Term Neurodevelopmental Outcome of Neonates with Hypernatremic Dehydration.
    Breastfeed Med 2017 Apr 22;12:163-168. Epub 2017 Mar 22.
    4 Division of Medical Education, Mayfield House, University of Brighton , Brighton, United Kingdom .
    Background: Neonatal hypernatremic dehydration (NHD) is a dangerous condition that can lead to severe weight loss, renal impairment, and central nervous system complications. We aimed to evaluate the consequences of NHD in infants in their second year of life.

    Materials And Methods: This was a prospective case-control study in Ghaem hospital, Mashhad, Iran. Read More

    Clinical aspects of changes in water and sodium homeostasis in the elderly.
    Rev Endocr Metab Disord 2017 Mar;18(1):49-66
    FMC Extracorporeal Life Support Center, Fresenius Medical Care; Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.
    The population of elderly individuals is increasing worldwide. With aging, various hormonal and kidney changes occur, both affecting water homeostasis. Aging is a risk factor for chronic kidney disease (CKD) and many features of CKD are reproduced in the aging kidney. Read More

    Analyzing the efficacy of frequent sodium checks during hypertonic saline infusion after elective brain tumor surgery.
    Clin Neurol Neurosurg 2017 Feb 22;156:24-28. Epub 2017 Feb 22.
    Departments of Neurosurgery, Los Angeles, United States; Radiation Oncology, Los Angeles, United States; Head and Neck Surgery, Los Angeles, United States; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, United States. Electronic address:
    Objective: To assess the utility of frequent sodium checks (every 6h) in patients receiving hypertonic saline (HS) after elective brain tumor surgeries.

    Patients And Methods: A single-institution retrospective review of patients having undergone elective craniotomies for brain tumors and treated with postoperative continuous intravenous infusions of 3% HS was performed. Changes in serum sodium values were analyzed at different time points. Read More

    Severe Hypernatremia Caused by Acute Exogenous Salt Intake Combined with Primary Hypothyroidism.
    Electrolyte Blood Press 2016 Dec 31;14(2):27-30. Epub 2016 Dec 31.
    Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
    This report describes a case of severe hypernatremia with a serum sodium concentration of 188.1mmol/L caused by exogenous salt intake. A 26-year-old man diagnosed with Crohn's disease 5 years previously visited our clinic due to generalized edema and personality changes, with aggressive behavior. Read More

    Iatrogenic hypernatremia in hemodialysis patients: A result erroneous online conductivity monitor and conductivity meter reading.
    Hemodial Int 2017 Mar 8. Epub 2017 Mar 8.
    Renal Division, Morehouse School of Medicine, Atlanta, Georgia, USA.
    Hyponatremia is common in chronic kidney disease and in end stage kidney disease (ESKD) but hypernatremia is infrequent in ESKD. The incidence of hypernatremia is higher in ambulatory peritoneal dialysis (PD) than in hemodialysis (HD) patients. In PD patients it is often a result of excessive ultrafiltration but in HD it is often a result of dialysate composition errors. Read More

    Could dysnatremias play a role as independent factors to predict mortality in surgical critically ill patients?
    Medicine (Baltimore) 2017 Mar;96(9):e6182
    aDivision of Intensive Care Medicine, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo bIntensive Care Unit, São Francisco Hospital, Ribeirão Preto cSocial Medicine Department, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
    Several studies have demonstrated the impact of dysnatremias on mortality of intensive care unit (ICU) patients. The objective of this study was to assess whether dysnatremia is an independent factor to predict mortality in surgical critically ill patients admitted to ICU in postoperative phase.One thousand five hundred and ninety-nine surgical patients (58. Read More

    Effects of pneumoperitoneum on severe hypernatremia in an adult patient who underwent laparoscopic surgery of hydatid cysts.
    J Clin Anesth 2017 Feb 28;37:52-54. Epub 2016 Dec 28.
    Ramon y Cajal University Hospital, Ctra. Colmenar km 9, 100, Madrid.
    We describe the first case of severe hypernatremia associated to laparoscopic surgery for hydatid cyst in an adult patient after the use of hypertonic saline solution with complete resolution. Severe hypernatremia is an unusual fact at the immediate postoperative period but may have fatal consequences for the patient and need immediate action. The patient reached a serum sodium concentration of 179 mmol/L without adverse effects after 6 days of treatment. Read More

    Endocr Pract 2017 Feb 22. Epub 2017 Feb 22.
    From: 1Endocrine Institute, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
    Purpose Central diabetes insipidus (CDI) is a rare heterogeneous condition with various underlying causes. This study sought to increase the still-limited data on the clinical characteristics and long-term course in adults diagnosed with CDI. Methods Data on demographics, presentation, imaging findings, affected pituitary axes, treatment, and complications were collected retrospectively from the files of 70 adult patients with CDI followed at a referral endocrine clinic. Read More

    Zinc Toxicosis in a Boxer Dog Secondary to Ingestion of Holiday Garland.
    J Med Toxicol 2017 Feb 21. Epub 2017 Feb 21.
    New York State Animal Health Diagnostic Center, Ithaca, NY, 14853, USA.
    Introduction: Increased admissions occur in small animal veterinary emergency clinics during some holidays, and some of the increased caseload is due to ingestion of toxic substances. This report documents zinc toxicosis contributing to the death of a dog after ingestion of holiday tinsel garland.

    Case Study: A mature boxer dog presented with a 4-day history of vomiting and diarrhea. Read More

    Method of Hypertonic Saline Administration: Effects on Osmolality in Traumatic Brain Injury Patients.
    J Clin Neurosci 2017 May 15;39:147-150. Epub 2017 Feb 15.
    Department of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, TN 1211 21st Avenue South, 404 Medical Arts Building, Nashville, TN 37232, United States.; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN 1161 21st Ave. So., T4224 Medical Center North, Nashville, TN 37232, United States.
    Hypertonic saline (HTS) is an effective therapy for reducing intracranial pressure (ICP). The ideal method of administration is unknown. The purpose of this study was to evaluate the method of HTS infusion and time to goal osmolality. Read More

    A systematic review of known interventions for the treatment of chronic nonhypovolaemic hypotonic hyponatraemia and a meta-analysis of the vaptans.
    Clin Endocrinol (Oxf) 2017 Feb 18. Epub 2017 Feb 18.
    Otsuka Pharmaceutical Europe Ltd, Wexham, UK.
    International and national guidelines on the treatment of chronic nonhypovolaemic hypotonic hyponatraemia differ; therefore, we have undertaken this systematic review and meta-analysis to investigate the efficacy and safety of interventions for the treatment of chronic nonhypovolaemic hypotonic hyponatraemia. Following registration of the review protocol with PROSPERO, systematic literature searches were conducted to identify randomized and quasi-randomized controlled trials assessing any degree of fluid restriction or any drug treatment with the aim of increasing serum sodium concentration in patients with chronic nonhypovolaemic hypotonic hyponatraemia. Where appropriate, outcome data were synthesized in a meta-analysis. Read More

    The effect of nonpharmacological training on delirium identification and intervention strategies of intensive care nurses.
    Intensive Crit Care Nurs 2017 Feb 14. Epub 2017 Feb 14.
    Cumhuriyet University, Faculty of Health Sciences, Nursing Department, Sivas, Turkey. Electronic address:
    Objective: This study aims to investigate the effect of nonpharmacological intervention training on delirium recognition and the intervention strategies of intensive care (ICU) nurses.

    Method: This is a quasi-experimental study conducted using a pretest-posttest design. The study sample included a total of 95 patients staying in the medical ICU of a university hospital and 19 nurses working in these units. Read More

    [Hyponatremia and its etiology in pediatric patients admitted to the emergency room].
    Rev Med Inst Mex Seguro Soc 2017 ;55 Suppl 1:S64-S70
    Servicio de Cardiología Pediátrica, Hospital de Pediatría, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.
    Background: The importance of hyponatremia is underestimated despite it is a frequent alteration in a hospital environment. Usually no cause is investigated and it is treated as an isolated data. The aim was to determine the prevalence and etiology of hyponatremia in pediatric patients. Read More

    Hypernatremia in the Neonate: Neonatal Hypernatremia and Hypernatremic Dehydration in Neonates Receiving Exclusive Breastfeeding.
    Indian J Crit Care Med 2017 Jan;21(1):30-33
    Department of Paediatrics, Lata Mangeshkar Hospital, Hingna, Nagpur, Maharashtra, India.
    Aims And Objectives: Evaluation of neonatal hypernatremia and hypernatremic dehydration in neonates receiving exclusive breastfeeding.

    Introduction: Neonatal hypernatremia is a serious condition in the newborn period. We present infants with hypernatremic dehydration due to breast milk (BM) hypernatremia. Read More

    Neurologic manifestations of major electrolyte abnormalities.
    Handb Clin Neurol 2017 ;141:705-713
    Department of Neurology, Washington University, St. Louis, MO, USA. Electronic address:
    The brain operates in an extraordinarily intricate environment which demands precise regulation of electrolytes. Tight control over their concentrations and gradients across cellular compartments is essential and when these relationships are disturbed neurologic manifestations may develop. Perturbations of sodium are the electrolyte disturbances that most often lead to neurologic manifestations. Read More

    A case of central diabetes insipidus after ketamine infusion during an external to internal carotid artery bypass.
    J Clin Anesth 2017 Feb 25;36:72-75. Epub 2016 Nov 25.
    Department of Anesthesiology, Tulane Medical Center, New Orleans, LA, USA.
    Study Objective: We report the first teenage case of ketamine-induced transient central diabetes insipidus.

    Case Summary: The patient was an 18-year-old woman with moyamoya disease undergoing an external carotid to internal carotid bypass and given a low-dose ketamine infusion. After approximately 2 hours in the supine position, with 0. Read More

    A Quick Reference on Hypernatremia.
    Vet Clin North Am Small Anim Pract 2017 Mar;47(2):209-212
    Department of Veterinary Clinical Sciences, The Ohio State University, 601 Vernon L. Tharp Street, Columbus, OH 43210, USA.
    Hypernatremia most commonly is associated with water loss in excess of sodium or salt gain (typically associated with restriction of access to water). Most of the signs of hypernatremia arise from the central nervous system; the more rapid the development of hypernatremia, the more severe the neurologic signs are likely to be. Anorexia, lethargy, vomiting, muscular weakness, behavioral changes, disorientation, ataxia, seizures, coma, and death have been identified in dogs and cats with hypernatremia and hypertonicity. Read More

    Case Report: Severe hypernatremia from psychogenic adipsia.
    F1000Res 2017 11;6:34. Epub 2017 Jan 11.
    Division of Internal Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, USA.
    Hypernatremia is a common emergency room presentation and carries high mortality. We describe a case of a 56-year-old male patient with who presents with refusal to drink water for several weeks leading to the admission. He was diagnosed with psychogenic adipsia and was treated successfully with fluids, mirtazapine and clonazepam. Read More

    Complications in mechanically ventilated patients of Guillain-Barre syndrome and their prognostic value.
    J Neurosci Rural Pract 2017 Jan-Mar;8(1):68-73
    Department of Biostatistics, NIMHANS, Bengaluru, Karnataka, India.
    Introduction: The spectrum of various complications in critically ill Guillain-Barre syndrome (GBS) and its effect on the prognosis is lacking in literature. This study aimed at enumerating the complications in such a cohort and their significance in the prognosis and mortality.

    Materials And Methods: Retrospective case record analysis of all consecutive mechanically ventilated patients of GBS in neurology Intensive Care Unit (ICU) of a tertiary care institute for 10 years was done. Read More

    Metabolic toxicities in patients undergoing treatment for nonhematological malignancy: A cross-sectional study.
    Indian J Med Paediatr Oncol 2016 Oct-Dec;37(4):256-259
    Department of Radiation Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
    Objectives: The objective of this study was to evaluate the prevalence of metabolic toxicities in patients with different nonhematological malignancies admitted in oncology ward of a tertiary cancer care center while on treatment.

    Methods: We did this cross-sectional study over a period of 7 months (January-July 2013) for all adult patients (n = 280) who, while undergoing anti-cancer therapy at our center, got admitted to our oncology inpatient ward with metabolic toxicity. Grading of toxicity was done using National Cancer Institute Common Terminology Criteria for Adverse Events Version 4. Read More

    Reactivated cytomegalovirus proctitis in an immunocompetent patient presenting as nosocomial diarrhea: a case report and literature review.
    BMC Infect Dis 2017 Feb 1;17(1):113. Epub 2017 Feb 1.
    Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
    Background: Reactivated cytomegalovirus (CMV) infection has been known to cause significant morbidity and mortality in immunocompromised patients. However, CMV disease rarely develops in immunocompetent patients, and reported cases often present with a mild, self-limiting course, without severe life-threatening sequelae. While the colon is the most common gastrointestinal site affected by CMV disease in immunocompetent patients, rectal involvement is rarely reported. Read More

    [Extrapontine myelinolysis developed after aneurysmal subarachnoid hemorrhage (a case report and literature review)].
    Zh Vopr Neirokhir Im N N Burdenko 2016 ;80(6):82-87
    Polenov Russian Scientific Research Institute of Neurosurgery, the Branch of the Almazov Federal North-West Medical Research Centre, St. Petersburg, Russia.
    Topicality: Central pontine and extrapontine myelinolysis is a rare and dangerous form of the demyelinating process of undefined origin, the development of which is associated with a very low sodium level in the blood (hypernatremia).

    Objective: To describe a rare case of extrapontine myelinolysis as a complication occurring in the hemorrhagic period of anterior communicating artery aneurysm rupture as well as to demonstrate that this condition can be diagnosed intravitally.

    Conclusion: Clinical vigilance of extrapontine myelinolysis may promote the timely diagnosis and treatment of this disease, which is a potential cause of death. Read More

    Early oxytocin inhibition of salt intake after furosemide treatment in rats?
    Physiol Behav 2017 May 25;173:34-41. Epub 2017 Jan 25.
    Oklahoma State University - Center for Health Sciences, Tulsa, OK 74107, United States. Electronic address:
    Body fluid homeostasis requires a complex suite of physiological and behavioral processes. Understanding of the role of the central nervous system (CNS) in integrating these processes has been advanced by research employing immunohistochemical techniques to assess responses to a variety of body fluid challenges. Such techniques have revealed sex/estrogen differences in CNS activation in response to hypotension and hypernatremia. Read More

    Vasopressin Bolus Protocol Compared to Desmopressin (DDAVP) for Managing Acute, Postoperative Central Diabetes Insipidus and Hypovolemic Shock.
    Case Rep Endocrinol 2017 3;2017:3052102. Epub 2017 Jan 3.
    Department of Neurology, University of Missouri, Columbia, MO, USA.
    Introduction. Management of postoperative central diabetes insipidus (DI) can be challenging from changes in volume status and serum sodium levels. We report a case successfully using a dilute vasopressin bolus protocol in managing hypovolemic shock in acute, postoperative, central DI. Read More

    Consequences of Androctonus mauretanicus and Buthus occitanus scorpion venoms on electrolyte levels in rabbits.
    Heliyon 2017 Jan 5;3(1):e00221. Epub 2017 Jan 5.
    Laboratory of Venoms and Toxins, Pasteur Institute of Morocco, 1 Place Louis Pasteur, Casablanca, 20360, Morocco.
    Androctonus mauretanicus (A. mauretanicus) and Buthus occitanus (B. occitanus) scorpions, which belong to the Buthidae family, are the most venomous scorpions in Morocco. Read More

    Cerebral Salt Wasting Is the Most Common Cause of Hyponatremia in Stroke.
    J Stroke Cerebrovasc Dis 2017 Jan 16. Epub 2017 Jan 16.
    Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. Electronic address:
    Objective: The study aimed to evaluate the frequency, severity, and causes of hyponatremia in stroke and its influence on outcome.

    Materials And Methods: Consecutive computed tomography- or magnetic resonance imaging-proven stroke patients within 7 days of stroke were included. Severity of stroke was assessed using the National Institute of Health Stroke Scale and consciousness using the Glasgow Coma Scale. Read More

    Hypertonicity: Clinical entities, manifestations and treatment.
    World J Nephrol 2017 Jan;6(1):1-13
    Helbert Rondon-Berrios, Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, United States.
    Hypertonicity causes severe clinical manifestations and is associated with mortality and severe short-term and long-term neurological sequelae. The main clinical syndromes of hypertonicity are hypernatremia and hyperglycemia. Hypernatremia results from relative excess of body sodium over body water. Read More

    [Hypernatremia caused by treatment with GHB obtained via a doctor's prescription].
    Tijdschr Psychiatr 2017 ;59(1):47-51
    In the last few years, gamma hydroxybutyric acid (GHB) has been used increasingly as a party drug; this has led to a marked increase in the number of requests for professional help with the treatment of GHB addiction. Pharmaceutical GHB (sodium oxybate, the sodium-salt of GHB), registered for cataplexia in narcolepsy patients, is used off-label to treat the withdrawal symptoms associated with GHB addiction. Pharmaceutical GHB has a high sodium load. Read More

    Glucocorticoid-induced leucine zipper protein regulates sodium and potassium balance in the distal nephron.
    Kidney Int 2017 May 13;91(5):1159-1177. Epub 2017 Jan 13.
    Division of Nephrology, Department of Medicine, University of California, San Francisco, California, USA. Electronic address:
    Glucocorticoid induced leucine zipper protein (GILZ) is an aldosterone-regulated protein that controls sodium transport in cultured kidney epithelial cells. Mice lacking GILZ have been reported previously to have electrolyte abnormalities. However, the mechanistic basis has not been explored. Read More

    Adipsic diabetes insipidus in adult patients.
    Pituitary 2017 Jan 10. Epub 2017 Jan 10.
    Academic Department of Endocrinology, Beaumont Hospital/RCSI Medical School, Beaumont Road, Dublin 9, Co., Dublin, Ireland.
    Introduction: Adipsic diabetes insipidus (ADI) is a very rare disorder, characterized by hypotonic polyuria due to arginine vasopressin (AVP) deficiency and failure to generate the sensation of thirst in response to hypernatraemia. As the sensation of thirst is the key homeostatic mechanism that prevents hypernatraemic dehydration in patients with untreated diabetes insipidus (DI), adipsia leads to failure to respond to aquaresis with appropriate fluid intake. This predisposes to the development of significant hypernatraemia, which is the typical biochemical manifestation of adipsic DI. Read More

    Extra-pontine myelinolysis secondary to hypernatremia induced by postpartum water restriction.
    Neuroradiol J 2017 Feb 6;30(1):84-87. Epub 2017 Jan 6.
    2 Neurology Department, Max Superspeciality Hospital, Dehradun, India.
    A young adult female with restricted water intake during the postpartum period presented with history of progressive weakness, dizziness and tendency to fall with generalized slowing of movement. On examination, patient was anaemic, febrile and stuporous. Investigations revealed hypernatremia, delta waves in electroencephalogram (EEG) and features suggestive of extra-pontine myelinolysis on magnetic resonance imaging (MRI) of brain. Read More

    Disorders of Sodium and Water Homeostasis.
    Vet Clin North Am Small Anim Pract 2017 Mar 23;47(2):293-312. Epub 2016 Dec 23.
    Department of Veterinary Clinical Sciences, The Ohio State University, 601 Vernon L. Tharp Street, Columbus, OH 43210, USA.
    This review article discusses normal and abnormal sodium balance in small animals. The terms and concepts central to understanding normal sodium and water balance are presented as well as of the physiology of body fluid compartments and the movement of fluid between those compartments. As dysnatremia is a very common disorder across the spectrum of critically ill patients, the main focus of the article is to present several clinical examples of both acute and chronic hypernatremia and hyponatremia and their practical, clinical management. Read More

    Georgian Med News 2016 Nov(Issue):12-16
    Karaganda State Medical University, Kazakhstan.
    The article presents the analysis of the intensive therapy through the correction of persistent hypernatremia in neurosurgical patients after removal of brain tumors. The aim of this work was to evaluate the effectiveness of Sterofundin in the framework of complex therapy of hypernatremia in neurosurgical patients after removal of brain tumors. We analyzed the dynamics of the concentrations of sodium, potassium, chorus of the plasma, anion gap and buffer bases in the postoperative period of these patients. Read More

    Hydrochlorothiazide in intensive care unit-acquired hypernatremia: A randomized controlled trial.
    J Crit Care 2017 Apr 2;38:225-230. Epub 2016 Dec 2.
    Department of Intensive Care, Medical Centre Leeuwarden, PO Box 888, 8901 BK Leeuwarden, the Netherlands. Electronic address:
    Purpose: Thiazides are suggested as a treatment for intensive care unit (ICU)-acquired hypernatremia (IAH). The primary aim of the study was reducing serum sodium concentration (sNa) in patients with IAH with hydrochlorothiazide (HCT) in comparison to placebo. Secondary end points were a difference in urine sodium concentration (uNa) and duration of severe IAH. Read More

    Delayed recovery of adipsic diabetes insipidus (ADI) caused by elective clipping of anterior communicating artery and left middle cerebral artery aneurysms.
    N Z Med J 2016 Dec 16;129(1447):86-90. Epub 2016 Dec 16.
    Department of Neurosurgery, Beaumont Hospital, Dublin, Republic of Ireland.
    Adipsic diabetes insipidus (ADI) is an extremely rare complication following microsurgical clipping of anterior communicating artery aneurysm (ACoA) and left middle cerebral artery (MCA) aneurysm. It poses a significant challenge to manage due to an absent thirst response and the co-existence of cognitive impairment in our patient. Recovery from adipsic DI has hitherto been reported only once. Read More

    Cerebral Disorders of Calves.
    Vet Clin North Am Food Anim Pract 2017 Mar 8;33(1):27-41. Epub 2016 Dec 8.
    Department of Population Health & Pathobiology, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA. Electronic address:
    Neurologic diseases of the cerebrum are relatively common in cattle. In calves, the primary cerebral disorders are polioencephalomalacia, meningitis, and sodium toxicity. Because diagnostic testing is not always readily available, the practitioner must often decide on a course of treatment based on knowledge of the likely disease, as well as his or her own clinical experience. Read More

    Sodium supply influences plasma sodium concentration and the risks of hyper- and hyponatremia in extremely preterm infants.
    Pediatr Res 2017 Mar 9;81(3):455-460. Epub 2016 Dec 9.
    Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
    Background: Hyper- and hyponatremia occur frequently in extremely preterm infants. Our purpose was to investigate plasma sodium (P-Na) concentrations, the incidence of hyper- and hyponatremia, and the impact of possible predisposing factors in extremely preterm infants.

    Methods: In this observational study, we analyzed data from the EXtremely PREterm (< 27 wk. Read More

    Is Bicarbonate Therapy Useful?
    Vet Clin North Am Small Anim Pract 2017 Mar 18;47(2):343-349. Epub 2016 Nov 18.
    Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, Room 2112, Tupper Hall, Davis, CA 95616, USA. Electronic address:
    Despite concerns about the negative effects of metabolic acidosis, there is minimal evidence that sodium bicarbonate administration is an effective treatment. In addition, sodium bicarbonate therapy is associated with many adverse effects, including paradoxic intracellular acidosis, hypokalemia, hypocalcemia, hypernatremia, and hyperosmolality. Definitive recommendations regarding bicarbonate therapy are challenging as there is little high-quality evidence available. Read More

    The clinical predictors of shunt-dependent hydrocephalus following aneurysmal subarachnoid hemorrhage.
    Turk Neurosurg 2016 Oct 17. Epub 2016 Oct 17.
    YongHe Cardinal Tien Hospital.
    Aim: Shunt-dependent hydrocephalus (SDH) is a relatively common complication following aneurysmal subarachnoid hemorrhage (aSAH). Delay in diagnosis and treatment may worsen neurological outcome. This study was conducted to identify early clinical factors associated with SDH following aSAH. Read More

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