3,639 results match your criteria Hypernatremia


Hypernatremia is associated with poorer outcomes following aneurysmal subarachnoid hemorrhage: a nationwide inpatient sample analysis.

J Neurosurg Sci 2018 Dec 5. Epub 2018 Dec 5.

Department of Neurosurgery, State University of New York Upstate, Syracuse, NY, USA.

Background: Hypernatremia is one of the most common electrolyte disturbances following aneurysmal subarachnoid hemorrhage (aSAH) and has been correlated with increased mortality in single institution studies. We investigated this association using a large nationwide healthcare database.

Methods: We performed a retrospective analysis of adults between 2002 and 2011 with a primary diagnosis of aSAH using the Nationwide Inpatient Sample (NIS). Read More

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December 2018

Comparison of Serum Electrolytes Abnormality and Renal Function Status in Asphyxiated and Normal Baby in a Tertiary Level Hospital.

Mymensingh Med J 2018 Oct;27(4):723-729

Dr Mrinal Kanti Das, Assistant Registrar, Department of Paediatrics, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh.

Complication of perinatal asphyxia is a major cause of neonatal mortality & morbidity in developing countries. This comparative cross sectional study was conducted in Mymensingh Medical College Hospital, Mymensingh, Bangladesh from May 2012 to September 2012 to determine electrolytes & renal function status in perinatal asphyxia & their impact on outcome. Thirty term normal birth weight babies with perinatal asphyxia in neonatal ward were included as a case group and thirty term normal birth weight neonates of same gestational age, without perinatal asphyxia in the department of Gynae & Obs were enrolled as a control group. Read More

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October 2018

Addressing the inadvertent sodium and chloride burden in critically ill patients: a prospective before-and-after study in a tertiary mixed intensive care unit population.

Crit Care Resusc 2018 Dec;20(4):285-293

Department of Intensive and Critical Care Unit, Flinders Medical Centre, Adelaide, SA, Australia.

Background: Inadvertent fluid loading - and resultant sodium and chloride - is common in critically ill patients. Sources such as fluid used as vehicles for drug infusions and boluses (fluid creep) and maintenance fluid are a common cause. We hypothesised that total sodium and chloride loading can be safely reduced in critically ill patients both by the use of 5% glucose as a diluent for infusions and boluses, when possible, and by its use as a maintenance fluid. Read More

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December 2018
1 Read

Low-chloride versus high-chloride hypertonic solution for the treatment of subarachnoid hemorrhage-related complications (The ACETatE trial): study protocol for a pilot randomized controlled trial.

Trials 2018 Nov 14;19(1):628. Epub 2018 Nov 14.

Department of Critical Care Medicine, Mayo Clinic, Phoenix, AZ, 85054, USA.

Background: Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening condition that results from a ruptured cerebral vessel. Cerebral edema and vasospasm are common complications and frequently require treatment with hypertonic solutions, in particular hypertonic sodium chloride (NaCl). We have previously shown that hyperchloremia in patients with aSAH given hypertonic NaCl is associated with the development of acute kidney injury (AKI), which leads to higher morbidity and mortality. Read More

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November 2018
5 Reads

Preoperative serum sodium measurements and postoperative inpatient mortality: A case-control analysis of data from the South African Surgical Outcomes Study.

S Afr Med J 2018 Oct 2;108(10):847-851. Epub 2018 Oct 2.

Discipline of Anaesthesiology and Critical Care Medicine, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban; and Inkosi Albert Luthuli Central Hospital, Durban, South Africa.

Background: Abnormal preoperative serum sodium measurements have been shown to be associated with increased postoperative mortality in US and European surgical populations. It is possible that such measurements are also associated with increased postoperative mortality in a South African (SA) setting, but this is yet to be confirmed. Establishing whether preoperative serum sodium measurements are associated with postoperative mortality could have implications for perioperative risk stratification in SA settings. Read More

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October 2018
6 Reads

Serum electrolyte imbalance and prognostic factors of postoperative death in adult traumatic brain injury patients: A prospective cohort study.

Medicine (Baltimore) 2018 Nov;97(45):e13081

Electrolyte imbalances are common in traumatic brain injury. It shares the cause of perioperative morbidity and mortality. Types of intravenous fluid resuscitation, osmotic diuretics, massive blood loss, and intracranial pathology were considered as the potential factors to worsen electrolyte abnormalities in these patients. Read More

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November 2018
2 Reads

Presence of Probst Bundles Indicate White Matter Remodeling in a Dog With Corpus Callosum Hypoplasia and Dysplasia.

Front Vet Sci 2018 22;5:260. Epub 2018 Oct 22.

Neurology Department, Clinic of Small Animal Surgery, Vetsuisse-Faculty Zurich, Zurich, Switzerland.

Corpus callosum abnormalities (CCA) rarely occur in dogs and are related to hypo/adypsic hypernatremia and seizures. Hypoplasia and dysplasia of the corpus callosum (CC) with concomitant lobar holoprosencephaly is the most common variant. It is currently uncertain using conventional MRI if canine CCA reflects the failure of commissural fibers to develop or the failure of the commissural fibers to cross hemispheres. Read More

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October 2018
1 Read

Effect of acute hypernatremia induced by hypertonic saline administration on endothelial glycocalyx in rabbits.

Clin Hemorheol Microcirc 2018 Nov 2. Epub 2018 Nov 2.

Department of Anaesthesiology and Intensive Care Medicine, Charles University in Prague, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Czech Republic.

Background And Objective: The endothelial glycocalyx (EG) is fragile and sensitive to damage such as exposure to hypernatremia. Our aim was to describe the influence of hypernatremia on the EG in sublingual and brain microcirculation in rabbits.

Methods: Hypernatremia was induced by intravenous administration of 10% NaCl solution. Read More

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November 2018
7 Reads

Sodium valproate correcting hypernatremia of diabetes insipidus-a fortunate incident.

QJM 2018 Nov;111(11):817-818

Department of Comprehensive Nursing, Beit Balev, Nesher, The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.

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November 2018
4 Reads

Idiopathic central diabetes insipidus in an extreme premature infant: A case report.

Authors:
A Biset O Claris

Arch Pediatr 2018 Nov 22;25(8):480-484. Epub 2018 Oct 22.

Department of neonatology, Hôpital Femme-Mère-Enfant, hospices Civils de Lyon, 59, boulevard Pinel, 69677 Lyon, France; EA4128, université Claude Bernard Lyon 1, 43, boulevard du 11-Novembre-1918, 69100 Villeurbanne, France.

Context: Central diabetes insipidus (CDI) is a rare disease during the neonatal period, making it diagnosis difficult and delaying medical treatment.

Case Report: We report here a case of a premature infant born at 26 weeks gestation who, during his 1st month of life, presented persistent hypernatremia with polyuria despite increased fluid supply and low sodium intake. CDI diagnosis was suspected and then confirmed by the therapeutic test with vasopressin analog, in its oral form. Read More

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November 2018
9 Reads

Dialysate sodium concentration: The forgotten salt shaker.

Semin Dial 2018 Nov 21;31(6):563-568. Epub 2018 Oct 21.

Department of Nephrology, Tokyo Women's Medical University, Tokyo, Japan.

The concentration of sodium in dialysis fluid, a major determinant of extracellular fluid volume and blood pressure, plays a major role in the sodium balance in end-stage renal disease patients. A low dialysate sodium concentration (DNa) reduces interdialytic weight gain (IDWG) and blood pressure and might help ameliorate endothelial dysfunction and inflammation. However, low DNa can also increase the incidence of hypotensive episodes and muscle cramps. Read More

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November 2018
4 Reads

Posterior pituitary dysfunction following traumatic brain injury: review.

Pituitary 2018 Oct 17. Epub 2018 Oct 17.

Academic Department of Endocrinology, Beaumont Hospital/RCSI Medical School, Dublin, Ireland.

Neurohypophysial dysfunction is common in the first days following traumatic brain injury (TBI), manifesting as dysnatremia in approximately 1 in 4 patients. Both hyponatremia and hypernatremia can impair recovery from TBI and in the case of hypernatremia, there is a significant association with excess mortality. Hyponatremia secondary to syndrome of inappropriate antidiuretic hormone secretion (SIAD) is the commonest electrolyte disturbance following TBI. Read More

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October 2018
4 Reads

A Case of Fatal Dehydration During Police Custody.

Authors:
Brita Zilg

J Forensic Sci 2018 Oct 17. Epub 2018 Oct 17.

Swedish National Board of Forensic Medicine, Retzius väg 5, 171 65, Solna, Sweden.

In the forensic literature, fatal dehydration predominantly concerns young children or incapacitated elderly persons. The postmortem diagnosis of fatal dehydration can be challenging to confirm, especially if the preceding circumstances are unknown. Here presented is a case of a 23-year-old man who died while held in an isolation cell during police custody for 18 days. Read More

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October 2018
4 Reads

NICU Discharge Feeding Bundle Improves Accuracy of Postdischarge Feeding Preparation and Potentially Prevents Readmission.

Adv Neonatal Care 2018 Oct 15. Epub 2018 Oct 15.

Clinical Nutrition Department (Ms Vollrath, Ms Marshall, and Mr Rihn), Children's Hospital Colorado (Drs Rosenberg and Grover, Mss Gabrielski and Deacon), Aurora; and University of Colorado School of Medicine, Aurora (Drs Rosenberg, Grover).

Background: Hospitalized infants often need fortified human milk and formulas for growth in the neonatal intensive care unit and postdischarge. Parents must learn how to properly mix infant feedings.At the initial Children's Hospital Colorado follow-up visit, baseline data revealed a 50% rate of mixing inaccuracy of discharge feeding recipes and identified the readmission of 2 infants with life-threatening hypernatremia. Read More

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October 2018
2 Reads

Approach to and management of abnormalities in plasma sodium.

Authors:
G Decaux

Acta Clin Belg 2018 Oct 12:1-14. Epub 2018 Oct 12.

a Service de Médecine Interne , Hôpital Universitaire Erasme , Bruxelles , Belgium.

The differential diagnosis between hypertonic, isotonic and hypotonic hyponatremia are presented. The help of some usual serum (urea, uric acid and TCO) and urine parameters (mainly osmolality and sodium concentration) are discussed and help to determine the best treatment. Morbidity associated with untreated hyponatremia and with the different treatment available is also discussed. Read More

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October 2018
2 Reads

Lipid emulsion for acute organophosphate insecticide poisoning - a pilot observational safety study.

Clin Toxicol (Phila) 2018 Oct 11:1-7. Epub 2018 Oct 11.

a Department of Internal Medicine , Post Graduate Institute of Medical Education and Research , Chandigarh , India.

Introduction: Organophosphate (OP) poisoning is an important public health concern in South-Asia especially in the farming population. Treatment of OP poisoning has remained unchanged since decades and case fatality is 10-40% despite best supportive care, anticholinergic agents and oximes. A new antidote is the need of the hour. Read More

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October 2018
2 Reads
3.120 Impact Factor

Short- and long-term results of laparoscopic adrenalectomy for Conn's syndrome.

Wideochir Inne Tech Maloinwazyjne 2018 Sep 3;13(3):292-298. Epub 2018 Apr 3.

2 Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland.

Introduction: The primary treatment of Conn's syndrome (CS) is laparoscopic adrenalectomy and aims to normalize arterial blood pressure and biochemical parameters.

Aim: To analyse short- and long-term results of laparoscopic adrenalectomy for Conn's syndrome (CS).

Material And Methods: The analysis included 44 consecutive patients, who underwent laparoscopic adrenalectomy between 2004 and 2015 for CS. Read More

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September 2018
1 Read

Initial Fluid Therapy in Pediatric Diabetic Ketoacidosis: A comparison of Hypertonic Saline Solution and Normal Saline Solution.

Pediatr Endocrinol Diabetes Metab 2018 ;24(2):56-64

Division of Pediatric Intensive Care, Department of Pediatrics, Lady Hardinge Medical College and associated Kalawati Saran Children's Hospital, New Delhi - 110001, India.

Introduction: The optimal fluid therapy in children with DKA is a matter of debate, especially if we take into account its association with cerebral edema, the most important complication. Hypertonic Saline Solution is used in the treatment of cerebral edema, and also has been used for volume resuscitation in children with shock.

Aim Of Study: To compare the effects of 3% saline and 0. Read More

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January 2018
3 Reads

Hypernatremia due to Urea-Induced Osmotic Diuresis: Physiology at the Bedside.

Indian J Crit Care Med 2018 Sep;22(9):664-669

Director of Inpatient Hemodialysis-Davita Dialysis, University of Maryland Midtown Campus, Maryland, USA.

Hypernatremia secondary to urea-induced solute diuresis is due to the renal excretion of electrolyte-free water. This concept is explained here step-wise physiologically with the help of a clinical vignette. Read More

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September 2018
2 Reads

Juvenile-onset gout and adipsic diabetes insipidus: A case report and literature review.

J Int Med Res 2018 Nov 1;46(11):4829-4836. Epub 2018 Oct 1.

1 Department of General Internal Medicine, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Science (CAMS) and Peking Union Medical College (PUMC), Beijing, China.

The prevalence of juvenile-onset gout has been increasing. Hereditary factors and secondary diseases should be considered in these patients. Adipsic diabetes insipidus (ADI) is characterized by arginine vasopressin (AVP) deficiency, which results in hypotonic polyuria, and dysfunction of thirst osmoreceptors, which results in failure to generate a thirst sensation in response to hypernatremia. Read More

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November 2018
8 Reads

MRI of lobar holoprosencephaly in a cat with hypodipsic hypernatraemia.

JFMS Open Rep 2018 Jul-Dec;4(2):2055116918801602. Epub 2018 Sep 20.

Veterinary Medical Center, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.

Case Summary: A 2-year-old neutered female domestic shorthair cat presented with a history of hypodipsia, recurrent hypernatraemia, pelvic limb ataxia and tremor. The serum arginine vasopressin level was low for the serum osmolality. MRI of the brain revealed a failure of separation of the cerebrum, which manifested as absence of the rostral part of the corpus callosum, fornix and septum pellucidum, thus resulting in a single fused ventricle. Read More

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September 2018
2 Reads

Hypernatraemia in 39 hospitalised foals: clinical findings, primary diagnosis and outcome.

Aust Vet J 2018 Oct;96(10):385-389

Clovelly Intensive Care Unit, Scone Equine Hospital, 106 Liverpool Street, Scone, New South Wales 2337, Australia.

Objective: To evaluate hypernatraemia in foals presenting as medical emergencies to an intensive care unit (ICU) to determine the prevalence, clinical findings, primary diagnosis and outcome.

Methods: Retrospective case study of records from Thoroughbred foals aged less than 3 months that presented to an ICU as medical emergencies in 2002-12. Data retrieved included signalment, clinical findings, laboratory results, primary diagnosis and outcome. Read More

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October 2018
9 Reads

RegressionExplorer: Interactive Exploration of Logistic Regression Models with Subgroup Analysis.

IEEE Trans Vis Comput Graph 2018 Sep 13. Epub 2018 Sep 13.

We present RegressionExplorer, a Visual Analytics tool for the interactive exploration of logistic regression models. Our application domain is Clinical Biostatistics, where models are derived from patient data with the aim to obtain clinically meaningful insights and consequences. Development and interpretation of a proper model requires domain expertise and insight into model characteristics. Read More

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September 2018
1 Read

Triggers for active surveillance of adverse drug events in newborns.

Cad Saude Publica 2018 09 6;34(9):e00069817. Epub 2018 Sep 6.

Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brasil.

The study aimed to verify the application and performance of triggers for adverse drug events in hospitalized newborns. This prospective cohort study was conducted in the neonatal care units of a university hospital from March to September 2015. A list of triggers was developed for the identification of adverse drug events in this population. Read More

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September 2018
2 Reads

Initial hematocrit values after birth and peri/intraventricular hemorrhage in extremely low birth weight infants.

J Perinatol 2018 Nov 11;38(11):1471-1475. Epub 2018 Sep 11.

Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Objective: Ischemia followed by reperfusion plays a significant role in the pathogenesis of peri/intraventricular hemorrhage (P/IVH). Delayed cord clamping promotes placental transfusion to newborn and is associated with decreased P/IVH. We hypothesized that extremely low birth weight (ELBW) infants with higher initial hematocrit (Hct) after birth are less likely to develop P/IVH. Read More

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November 2018
1 Read

Approach and management of dysnatremias in cirrhosis.

Hepatol Int 2018 Nov 10;12(6):487-499. Epub 2018 Sep 10.

Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Policlinico S. Orsola-Malpighi, Via Albertoni, 15, 40138, Bologna, Italy.

Hypervolemic (dilutional) hyponatremia is the most common dysnatremia in cirrhosis, with a prevalence close to 50% in patients with ascites, while hypovolemic hyponatremia occurs in a minority of cases. Hyponatremia carries a poor prognosis, being associated with increased mortality and reduced survival after liver transplantation. Hypernatremia is rarer and is also associated with an adverse prognosis. Read More

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November 2018
3 Reads

A Rare Case of Severe Metabolic Alkalosis with Unusual Hyperproteinemia Treated with Continuous Renal Replacement Therapy and Regional Citrate Anticoagulation.

Case Rep Nephrol Dial 2018 May-Aug;8(2):138-146. Epub 2018 Aug 3.

Department of Anaesthesiology and Intensive Care, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.

A 23-year-old woman was referred to the tertiary centre with acute kidney injury and severe metabolic alkalosis following an accidental ethylene glycol poisoning. The patient had been treated with continuous haemodiafiltration and regional citrate anticoagulation, and a tracheostomy was performed due to pneumonia. Besides severe metabolic alkalosis and hypernatremia, the laboratory tests revealed total protein of 108 g/L on admission to the tertiary centre. Read More

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August 2018
1 Read

ADHD symptoms in a young patient with central diabetes insipidus.

Atten Defic Hyperact Disord 2018 Dec 29;10(4):317-320. Epub 2018 Aug 29.

Child and Adolescent Psychiatry Department, Robert Debré Hospital, 48 Boulevard Sérurier, 75019, Paris, France.

Diabetes insipidus is known to be associated with neurodevelopmental disorders. In this case report, we present a child suffering from a central diabetes insipidus (DI) and an attention-deficit/hyperactivity disorder (ADHD). The DI was due to a mutation on the vasopressin gene, impairing its secretion. Read More

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December 2018
2 Reads

Variable saline resuscitation in a murine model of combined traumatic brain injury and haemorrhage.

Brain Inj 2018 Aug 23:1-9. Epub 2018 Aug 23.

a Division of Research, Institute for Military Medicine, Department of Surgery , University of Cincinnati , Cincinnati , OH , USA.

Background: Resuscitation strategies for combined traumatic brain injury (TBI) with haemorrhage in austere environments are not fully established. Our aim was to establish the effects of various saline concentrations in a murine model of combined TBI and haemorrhage, and identify an effective resuscitative strategy for the far-forward environment.

Methods: Male C57BL/6 mice underwent closed head injury and subjected to controlled haemorrhage to a systolic blood pressure of 25 mmHg via femoral artery cannulation for 60 min. Read More

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August 2018
3 Reads

Double Trouble - Severe Hypernatremia Secondary to Central Diabetes Insipidus Complicated by Hypercalcemic Nephrogenic Diabetes Insipidus: A Case Report.

Am J Case Rep 2018 Aug 18;19:973-977. Epub 2018 Aug 18.

Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.

BACKGROUND Patients with malignancies often have electrolyte abnormalities. We present a case of a patient with central diabetes insipidus secondary to metastatic pituitary invasion complicated by hypercalcemic nephrogenic diabetes insipidus. CASE REPORT We present a case of 40-year-old female with a history of stage IV breast cancer with skeletal and leptomeningeal metastasis, who was admitted with polyuria, polydipsia, and recent onset of confusion. Read More

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August 2018
2 Reads

A Case of Diabetic Ketoacidosis Presenting with Hypernatremia, Hyperosmolarity, and Altered Sensorium.

Case Rep Endocrinol 2018 16;2018:4806598. Epub 2018 Jul 16.

Department of Internal Medicine, St. Joseph's University Medical Center-New York Medical College, USA.

Diabetic Ketoacidosis commonly presents with hyponatremia, but hypernatremia is a rare entity. We report a unique case of a 50-year-old woman admitted with altered sensorium with blood glucose 979 milligrams/deciliter, serum osmolarity 363 mOsm/kilograms, and serum sodium 144 milliequivalents/liter. Patient was given initial bolus of isotonic saline and continued on half isotonic saline for correction of hypernatremia along with insulin infusion therapy. Read More

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July 2018
2 Reads

Potassium Conservation is Impaired in Mice with Reduced Renal Expression of Kir4.1.

Am J Physiol Renal Physiol 2018 08 15. Epub 2018 Aug 15.

Medicine, University of Rochester, United States.

To better understand the role of the inward-rectifying K channel, Kir4.1 (KCNJ10), in the distal nephron, we initially studied a global Kir4.1 knock out mouse (gKO) which demonstrated the hypokalemia and hypomagnesemia seen in SeSAME/EAST syndrome and was associated with reduced Na/Cl cotransporter (NCC) expression. Read More

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August 2018
4 Reads

Incomplete Refractory Kawasaki Disease in an Infant-A Case Report and a Review of the Literature.

Front Pediatr 2018 27;6:210. Epub 2018 Jul 27.

Department of Pediatrics, University of Medicine and Pharmacy TîrguMures, Târgu Mures, Romania.

Kawasaki disease (KD) is a febrile vasculitis, which is commonly defined by fever and at least four specific clinical symptoms. Incomplete KD is defined by suggestive echocardiographic findings with an incomplete clinical picture. Refractory KD is diagnosed in patients resistant to intravenous immunoglobulin (IVIG). Read More

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July 2018
2 Reads

Hypernatremia and Coagulopathy May or May Not Be Useful Clinical Biomarkers in Dogs with Head Trauma: A Retrospective Study.

J Neurotrauma 2018 Dec 27;35(23):2820-2826. Epub 2018 Sep 27.

1 Department of Small Animal Medicine and Surgery, Epidemiology and Information Processing, University of Veterinary Medicine , Hannover, Germany .

This study was performed to evaluate clinical biomarkers as prognostic values in dogs with traumatic brain injury (TBI) based on findings in human patients. Sodium levels of 158 dogs with TBI and 169 patients with trauma without involvement of the head except head trauma (EHT) were examined. TBI patients with hypernatremia had a slightly higher risk of dying (22. Read More

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December 2018
2 Reads

An Interesting Case of Polyuria in a Child.

Indian J Clin Biochem 2018 Jul 19;33(3):365-367. Epub 2017 Dec 19.

Nepal Army Institute of Health Sciences, Kathmandu, Nepal.

A 1 year old male child with increased frequency of urine associated with increased thirst was found to have some developmental delays. Laboratory investigations showed increased serum sodium level and serum osmolality with decreased urine osmolality. An empty sella turcica was seen in contrast brain MRI; however focal demyelinating lesion was not present. Read More

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July 2018
3 Reads

Early Hypophosphatemia in High-Risk Preterm Infants: Efficacy and Safety of Sodium Glycerophosphate From First Day on Parenteral Nutrition.

JPEN J Parenter Enteral Nutr 2018 Aug 2. Epub 2018 Aug 2.

Division of Neonatology, Hospital Universitario 12 de Octubre, Madrid, Spain.

Background: Early hypophosphatemia is common in premature infants ≤1250 g. The aim of this study was to assess the frequency and severity of hypophosphatemia after sodium glycerophosphate supplementation from first day of life in parenteral nutrition and to address the safety of this practice.

Methods: Prospective cohort study of infants ≤1250 g birth weight born in a tertiary-care level neonatal intensive care unit and supplied with sodium glycerophosphate from the first day of life. Read More

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August 2018
6 Reads

Intracranial pathologies associated with central diabetes insipidus in infants.

J Pediatr Endocrinol Metab 2018 Jul 27. Epub 2018 Jul 27.

University of Tennessee Health Science Center, Memphis, TN, USA.

Background Idiopathic central diabetes insipidus (CDI) has been associated with intracranial pathologies that do not involve the structural pituitary gland or hypothalamus. The objective was to study the association between non-structural hypothalamic/pituitary intracranial pathologies (NSHPIP) with CDI and to review etiologies that may be contributory to the development of CDI. Methods A retrospective query of our intra-institutional database from 2006 to 2015. Read More

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July 2018
5 Reads

The Different Expression Patterns of HSP22, a Late Embryogenesis Abundant-like Protein, in Hypertrophic H9C2 Cells Induced by NaCl and Angiotensin II.

Electrolyte Blood Press 2018 Jun 30;16(1):1-10. Epub 2018 Jun 30.

Integrated Biomedical and Life Science, College of Health Science, Korea University, Seoul, Korea.

Background: High-NaCl diet is a contributing factor for cardiac hypertrophy. The role of HSP22 as a protective protein during cardiac hypertrophy due to hypernatremia is unclear. Accordingly, this study aimed to establish a cellular hypernatremic H9C2 model and to compare the expression of HSP22 in Ca homeostasis between a high-NaCl and angiotensin II-induced hypertrophic cellular H9C2 model. Read More

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June 2018
16 Reads

Dysnatremia in Renal Failure.

Contrib Nephrol 2018 24;196:229-236. Epub 2018 Jul 24.

Proximal salt reabsorption in the hypertrophied tubules in the early phase of chronic renal failure (CRF) would be diminished according to the inhibited expression of proximal salt-transporting molecules, which may be facilitated by the inhibition of Na-K-ATPase expression. Results from animal models suggest that patients with early-phase CRF would easily develop hyponatremia and, in contrast, patients showing developed CRF would be more likely to show dehydration or hypernatremia. Several large-scale studies of individuals with chronic kidney disease (CKD) revealed that hyponatremia is much more common than hypernatremia in patients with earlier stages of CKD. Read More

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July 2018
3 Reads

Donor Hypernatremia is Not Related with the Duration of Postoperative Mechanical Ventilation, Primary Graft Dysfunction, or Long-Term Outcome Following Lung Transplantation.

Ann Transplant 2018 Jul 24;23:500-506. Epub 2018 Jul 24.

Department of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

BACKGROUND Donor hypernatremia has been associated with reduced graft and recipient survival after heart, liver, kidney, and pancreas transplantation. However, it is unknown what effect donor hypernatremia has on graft and recipient outcomes after lung transplantation. The aim of this study was to investigate the relation of donor hypernatremia with the duration of postoperative mechanical ventilation, the incidence of severe primary graft dysfunction, and survival following lung transplantation. Read More

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July 2018
8 Reads

Hypopituitarism: Case Study Involving Hypernatremia Prompting Discovery of a Pituitary Disorder in a Patient With Lymphoma.

Authors:
Jace D Johnny

Clin J Oncol Nurs 2018 Aug;22(4):E115-E119

University of Utah.

Background: The endocrine system contributes to numerous physiologic processes. Compensatory mechanisms are in place that can assist when endocrine dysfunction occurs, which may make it difficult to identify pathologic states.

Objectives: The case study in this article presents a 74-year-old woman with diffuse large B-cell lymphoma who was admitted to an oncology critical care unit with neutropenic fevers and suspicion of gastrointestinal bleeding. Read More

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August 2018
15 Reads

Effect of Hypernatremia on Outcomes After severe Traumatic Brain Injury: A Nationwide Inpatient Sample analysis.

World Neurosurg 2018 Oct 18;118:e880-e886. Epub 2018 Jul 18.

Department of Neurosurgery, State University of New York Upstate Medical University, Syracuse, New York, USA.

Objective: Induced hypernatremia is frequently used to reduce intracranial pressure in patients with severe traumatic brain injury (TBI). This technique is controversial, and some studies have independently associated hypernatremia with worse outcomes after TBI. We sought to investigate this potential association in a large healthcare database. Read More

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October 2018
2 Reads

Weight loss thresholds to detect early hypernatremia in newborns.

J Pediatr (Rio J) 2018 Jul 18. Epub 2018 Jul 18.

Universidad Miguel Hernández de Elche, Departamento de Farmacología, Pediatría y Química Orgánica, Alicante, Spain.

Objective: The literature indicates a single universal cut-off point for weight loss after birth for the risk of hypernatremia, without considering other factors. The aim of this study was to construct and internally validate cut-off points for the percentage weight loss associated with the risk of hypernatremia, taking into account risk factors.

Methods: A prospective study with a three-day follow-up was conducted in 165 neonates with a gestational age ≥35 weeks. Read More

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July 2018
4 Reads

Let food be thy medicine and medicine be thy food?

Clin Kidney J 2018 Apr 26;11(2):162-165. Epub 2018 Feb 26.

Renal Unit, Royal Hospital for Children, Glasgow, UK.

Ensuring adequate nutrition in children with chronic kidney disease whilst avoiding hyperkalaemia can be a difficult balance to achieve. Pre-treatment of feeds, whether milk, formula or enteral nutrition, with sodium polystyrene sulfonate (SPS) is practiced in some paediatric centres internationally. Such treatments are purported to avoid the potentially serious complications of direct administration of SPS, such as intestinal necrosis, aspiration pneumonitis and metabolic alkalosis to name but a few. Read More

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April 2018
2 Reads

Case Study: Extreme Weight Making Causes Relative Energy Deficiency, Dehydration and Acute Kidney Injury in a Male Mixed Martial Arts Athlete.

Int J Sport Nutr Exerc Metab 2018 Jul 10:1-20. Epub 2018 Jul 10.

1 Research Institute for Sport and Exercise Sciences. Liverpool John Moores University, Liverpool, UK.

The aim of the present case study was to quantify the physiological and metabolic impact of extreme weight cutting by an elite male MMA athlete. Throughout an 8-week period, we obtained regular assessments of body composition, resting metabolic rate (RMR), VO and blood clinical chemistry to assess endocrine status, lipid profiles, hydration and kidney function. The athlete adhered to a "phased" weight loss plan consisting of 7 weeks of reduced energy (ranging from 1300 - 1900 kcal. Read More

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July 2018
27 Reads

Could sodium imbalances predispose to postoperative venous thromboembolism? An analysis of the NSQIP database.

Thromb J 2018 3;16:11. Epub 2018 Jul 3.

1Department of Internal Medicine, American University of Beirut Medical Center, Riad El Solh 110 72020, Beirut, Lebanon.

Background: Hyponatremia is common among patients with pulmonary embolism, while hypernatremia increases the risk of venous thromboembolism (VTE). Our objective was to evaluate the association between sodium imbalances and the incidence of VTE and other selected perioperative outcomes.

Methods: We conducted a retrospective cohort study using the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) and identified 1,108,704 patients undergoing major surgery from 2008 to 2012. Read More

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July 2018
17 Reads

Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis.

Crit Care Med 2018 Sep;46(9):1411-1420

Department of Medicine, McMaster University, Hamilton, ON, Canada.

Objective: This systematic review and meta-analysis addresses the efficacy and safety of corticosteroids in critically ill patients with sepsis.

Data Sources: We updated a comprehensive search of MEDLINE, EMBASE, CENTRAL, and LILACS, and unpublished sources for randomized controlled trials that compared any corticosteroid to placebo or no corticosteroid in critically ill children and adults with sepsis.

Study Selection: Reviewers conducted duplicate screening of citations, data abstraction, and, using a modified Cochrane risk of bias tool, individual study risk of bias assessment. Read More

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September 2018
9 Reads
1 Citation
6.310 Impact Factor

Strategies to reduce readmissions for hyponatremia after transsphenoidal surgery for pituitary adenomas.

Endocrine 2018 11 30;62(2):333-339. Epub 2018 Jun 30.

Division of Endocrinology, Metabolism and Diabetes, University of Colorado, Anschutz Medical Campus, Denver, CO, 80045, USA.

Purpose: Disorders of water balance, particularly hyponatremia from altered antidiuretic hormone (ADH) secretion, are a common post-operative complication of transsphenoidal surgery (TSS). We present our results from implementation of a 2-week 1.5 liter/daily fluid restriction on readmission rates for hyponatremia. Read More

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November 2018
12 Reads