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Nutrients 2020 Jun 19;12(6). Epub 2020 Jun 19.

Department of Laboratory Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland.

Dysmagnesemia is a serious disturbance of microelement homeostasis. The aim of this study was to analyze the distribution of serum magnesium concentrations in hospitalized patients according to gender, age, and result of hospitalization. The study was conducted from February 2018 to January 2019 at the Central Clinical Hospital in Warsaw. Read More

J Vet Pharmacol Ther 2020 Jun 11. Epub 2020 Jun 11.

College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.

The objectives of this study were to describe pharmacokinetic and pharmacodynamic changes as a result of a single intravenous administration of magnesium sulfate (MgSO ) to healthy horses. MgSO is a magnesium salt that has been used to calm horses in equestrian competition and is difficult to regulate because magnesium is an essential constituent of all mammals. Six healthy adult female horses were administered a single intravenous dose of MgSO at 60 mg/kg of body weight over 5 min. Read More

Ann Palliat Med 2020 May;9(3):1134-1143

Beijing Xiaotangshan Hospital Medical Laboratory, Beijing 102211, China.

Background: In recent years, the concentration of magnesium in dialysis patients has drawn an increasing amount of attention. Both hemodialysis and peritoneal dialysis may affect magnesium metabolism, but studies in this area are very limited. This study aimed to investigate the serum magnesium concentrations in hemodialysis patients and examine the factors related to the serum magnesium concentration, and to explore the effect of hemodialysis with conventional hemodialysis solution (magnesium ion concentration 0. Read More

J Emerg Med 2020 May 7;58(5):767-770. Epub 2020 May 7.

Department of Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: Hypermagnesemia is an often overlooked electrolyte abnormality that has a myriad of presenting symptoms. It has been observed after both accidental and intentional ingestions of magnesium-containing compounds, and as in the case presented, Epsom salts, which are primarily magnesium sulfate.

Case Report: A 56-year-old man presented to the emergency department reporting weakness after an ingestion of Epsom salts used as a laxative and was found to be bradycardic and hypotensive. Read More

Hypertens Pregnancy 2020 Aug 25;39(3):221-227. Epub 2020 Apr 25.

Department Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga , Surabaya, Indonesia.

Objective: To evaluate the maternal-neonatal outcome in magnesium (Mg)-intoxicated women with preeclampsia with severe features (PESF) treated with magnesium sulfate (MgSO).

Methods: A total of 19 Mg intoxicated PESF women (cases) were compared with 166 PESF women without signs of intoxication (controls).

Results: Mg serum levels of cases was higher compared to control group (12. Read More

J Equine Vet Sci 2020 May 12;88:102840. Epub 2019 Nov 12.

Clinical Pathology Platform, Department for Pathobiology, University of Veterinary Medicine, Vienna, Austria.

A 14-year-old Zweibrücker Warmblood gelding was presented for evaluation of lethargy and headshaking. The horse had a history of bouts of lameness in different limbs and back problems. It also had many mild colic episodes in the past. Read More

BMC Pregnancy Childbirth 2020 Apr 9;20(1):208. Epub 2020 Apr 9.

Department of Pediatrics, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, 300, Boa Vista, Recife, Pernambuco, CEP: 50070-550, Brazil.

Background: Preeclampsia is the major cause of maternal morbidity and mortality in developing countries. Magnesium sulfate is considered first-line therapy against eclampsia and magnesium deficiency in pregnancy has been associated with unfavourable perinatal outcomes. However there are doubts if magnesium supplementation during pregnancy can previne preeclampsia especially in population with high nutritional risk. Read More

Hosp Pharm 2020 Apr 18;55(2):82-83. Epub 2019 Dec 18.

The University of Texas MD Anderson Cancer Center, Houston, USA.

Cureus 2020 Feb 8;12(2):e6922. Epub 2020 Feb 8.

Biochemistry, Xavier University School of Medicine, Oranjestad, ABW.

Floppy infant syndrome, also sometimes referred to as rag-doll syndrome, is characterized by hypotonia that could present as either peripheral hypotonia or central. Depending on the origin of hypotonia, the infant will present with different symptoms that ultimately have the characteristic feature of hypotonia. The clinical examination is crucial in diagnosing floppy infant syndrome in the neonate period, but the most critical factor is investigating and diagnosing the underlying cause of hypotonia. Read More

BMC Nephrol 2020 Feb 12;21(1):49. Epub 2020 Feb 12.

Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue - Q7, Cleveland, OH, 44195, USA.

Introduction: Magnesium disorders are commonly encountered in chronic kidney disease (CKD) and are typically a consequence of decreased kidney function or frequently prescribed medications such as diuretics and proton pump inhibitors. While hypomagnesemia has been linked with increased mortality, the association between elevated magnesium levels and mortality is not clearly defined. Additionally, associations between magnesium disorders, type of death, and CKD progression have not been reported. Read More

Hosp Pract (1995) 2020 Mar 8;48(2):80-85. Epub 2020 Feb 8.

Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic , Rochester, MN, USA.

Background: The impact of admission serum magnesium on long-term mortality in hospitalized patients was unclear. This study aimed to assess the long-term mortality risk based on admission of serum magnesium in hospitalized patients.

Methods: This was a retrospective cohort study conducted at a tertiary referral hospital. Read More

Hosp Pharm 2020 Feb 17;55(1):64-68. Epub 2018 Dec 17.

Augusta University Medical Center, GA, USA.

Due to the renal handling mechanism of magnesium, prolonging the time for infusion of intravenous (IV) magnesium has been postulated to decrease magnesium requirements; however, a paucity of clinical evidence exists to support prolonging infusion rates. To assess if there is a difference in magnesium replacement required in the medicine population at an academic medical center when prolonged infusion rates (0.5 g/h) are compared to short infusion rates of > 0. Read More

Front Vet Sci 2019 21;6:414. Epub 2019 Nov 21.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, United States.

The objective of this study was to characterize the pharmacokinetics and pharmacodynamics of intravenous administration of magnesium sulfate to horses using a novel radio-telemetry system for physiologic signal capture. Five Horses were surgically implanted with a radio-telemetric carotid catheter. Implants were paired with a non-invasive telemetric unit which acquired a six lead ECG and 3-axis acceleration to assess activity acquired wirelessly in real-time for future analysis. Read More

Emerg Med Australas 2020 Apr 17;32(2):303-312. Epub 2019 Dec 17.

Emergency Department, Austin Hospital, Melbourne, Victoria, Australia.

Objective: The utility of calcium, magnesium and phosphate measurement in the ED is limited. We aimed to determine clinical risk variables for abnormal levels of these electrolytes in order to inform the development of an ordering guideline.

Methods: We performed a retrospective, observational study of patients who presented to a tertiary referral ED between January and June 2017. Read More

Eur J Intern Med 2019 Dec 4;70:e22-e24. Epub 2019 Nov 4.

Department of Clinical and Experimental Medicine; University Hospital of Messina; Via C. Valeria, 98125 Messina, Italy.

Int J Mol Sci 2019 Oct 30;20(21). Epub 2019 Oct 30.

Institute of Physiology, Kiel University, Christian-Albrechts-Platz 4, 24118 Kiel, Germany.

Claudins are key components of the tight junction, sealing the paracellular cleft or composing size-, charge- and water-selective paracellular channels. Claudin-10 occurs in two major isoforms, claudin-10a and claudin-10b, which constitute paracellular anion or cation channels, respectively. For several years after the discovery of claudin-10, its functional relevance in men has remained elusive. Read More

J Pediatr Gastroenterol Nutr 2019 12;69(6):e151-e157

Baxter Healthcare Corporation, Deerfield, IL.

Objectives: Hypermagnesemia has been reported in preterm neonates treated with commercial pediatric triple-chamber bag (3CB) parenteral nutrition (PN). This postmarketing study was requested by the European Medicines Agency to assess the safety of a 3CB PN product in full-term neonates and children up to 24 months of age.

Methods: This prospective, multicenter, observational study enrolled hospitalized, full-term, newborn infants and children up to 24 months of age receiving >70% of nutrition as PN and requiring ≥50% of nutrition as PN for ≥5 days. Read More

J Clin Biochem Nutr 2019 Jul 1;65(1):76-81. Epub 2019 Jul 1.

Department of Gastroenterology, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan.

Although magnesium oxide is widely used as a laxative, alterations in serum magnesium concentrations among patients taking daily magnesium oxide have not been clarified. The present retrospective, cross-sectional study investigated the risk factors for hypermagnesemia in patients taking daily oral magnesium oxide. Of 2,176 patients administered daily magnesium oxide, 193 (8. Read More

J Diabetes Complications 2019 10 2;33(10):107402. Epub 2019 Jul 2.

Late-stage Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.

Aims: Hypomagnesemia (serum magnesium [Mg] <0.74 mmol/L [<1.8 mg/dL]) is commonly observed in patients with type 2 diabetes (T2D). Read More

Therap Adv Gastroenterol 2019 19;12:1756284819851510. Epub 2019 May 19.

Ferring Pharmaceuticals Inc., Parsippany, NJ, USA Hackensack University Medical Center, Hackensack, NJ, USA.

Background: We performed a randomized, controlled, assessor-blinded, multicenter, non-inferiority (NI) study to compare the safety and efficacy of a ready-to-drink formulation of sodium picosulfate, magnesium oxide, and citric acid (SPMC oral solution) with a powder formulation (P/MC powder) for oral solution.

Methods: Eligible participants (adults undergoing elective colonoscopy) were randomized 1:1 to split-dose SPMC oral solution or P/MC powder. The primary efficacy endpoint assessed overall colon-cleansing quality with the Aronchick Scale (AS), and the key secondary efficacy endpoint rated quality of right colon cleansing with the Boston Bowel Preparation Scale (BBPS). Read More

Hemodial Int 2019 10 21;23(4):E106-E110. Epub 2019 May 21.

Department of Nephrology, KEM Hospital, Pune, India.

As maintenance hemodialysis patients are exposed to large quantities of dialysis water, any contamination of it might be reflected in plasma levels. We present a series of cases due to such a contamination. Six maintenance hemodialysis patients dialyzing at the same peripheral hemodialysis facility presented to us over a short period of time with symptoms mimicking inadequate dialysis. Read More

Front Pharmacol 2019 26;10:429. Epub 2019 Apr 26.

Department of Surgery, Anesthesiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

The use of magnesium sulfate in the perioperative period has several benefits, including analgesia, inhibition of the release of catecholamines and prevention of vasospasm. The aim of this survey was to provide an overview of the use of magnesium sulfate in anesthesia. This was a prospective descriptive cross-sectional study. Read More

PLoS One 2019 25;14(4):e0215673. Epub 2019 Apr 25.

Department of Internal Medicine, Diakonhjemmet Hospital, Oslo, Norway.

Background: Although electrolyte imbalances (EIs) are common in the emergency department (ED), few studies have examined the occurrence of such conditions in an unselected population.

Objectives: To investigate the frequency of EI among adult patients who present to the ED, with regards to type and severity, and the association with age and sex of the patient, hospital length of stay (LOS), readmission, and mortality.

Methods: A retrospective cohort study. Read More

Blood Purif 2019 3;47 Suppl 2:88-94. Epub 2019 Apr 3.

Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan,

Background/aims: Although hypomagnesemia was found to be a risk for cardiovascular diseases in the general population, the relationship between serum magnesium (Mg) levels and prognosis of patients on maintenance hemodialysis (MHD) has not been extensively studied. This study sought to determine the relationship of serum Mg levels with aortic arch calcification (AoAC) and mortality in Japanese MHD patients.

Methods: We measured serum Mg levels in a cohort of 392 patients on MHD, classified the patients into 3 groups according to these levels, and followed their course for 4 years. Read More

J Nephrol 2019 Oct 19;32(5):791-802. Epub 2019 Mar 19.

Department of Nephrology, Institute of Nephrology of Chongqing and Kidney Center of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China.

Background: Previous studies reported that magnesium deficiency was associated with vascular calcifications, atherosclerosis and cardiovascular disease, which might play an independent pathogenic role in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients. However, the results of these studies were somewhat underpowered and inconclusive.

Methods: Literature was identified by searching PubMed, EMBASE, Web of Science and the Cochrane Central Register of Controlled Trials (CENTRAL). Read More

J Pharm Health Care Sci 2019 13;5. Epub 2019 Feb 13.

1Department of Pharmacy, Mie University Hospital, 2-174, Edobashi, Tsu, Mie 514-8507 Japan.

Background: Magnesium oxide (MgO), an antacid and laxative, is widely used in Japan to treat constipation and peptic ulcers. Because serum Magnesium (Mg) levels are elevated in elderly and/or patients with renal failure, its periodic monitoring is recommended for patients prescribed MgO, in order to prevent MgO-induced hypermagnesemia. However, there is little information regarding the factors contributing to the development of MgO-induced hypermagnesemia. Read More

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):735-739

Department of Biochemistry, GGS Medical College, Faridkot, Punjab, India.

Parathyroid hormone (PTH) is the main regulator of calcium, phosphate, magnesium, sodium, and potassium homeostasis. Therefore, this study was conducted to evaluate the relationship between PTH and aforementioned minerals in end-stage renal disease (ESRD) patients.

Aim: The aim of this study was to estimate serum intact parathormone (iPTH) and other biochemical parameters in ESRD patients and to find correlation between serum iPTH and biochemical parameters in the study group. Read More

Pflugers Arch 2019 04 6;471(4):619-631. Epub 2019 Feb 6.

Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Fahrstr. 17, 91054, Erlangen, Germany.

Magnesium (Mg) abnormalities during sepsis have been reported, but the underlying mechanisms during acute inflammation are poorly understood. We hypothesized that a decrease in GFR and/or changes in transporters or channels for Mg could be responsible for the observed Mg abnormalities. Therefore, we studied the metabolism of Mg in a murine model of endotoxemia. Read More

Blood Purif 2019 30;47 Suppl 1:1-7. Epub 2019 Jan 30.

Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Objective: This retrospective study aimed to investigate the clearance of magnesium (Mg) in peritoneal dialysis (PD) patients and its influencing factors.

Methods: The demographic information, clinical characteristics and laboratory data of the patients were collected. According to the corrected serum Mg (cS-Mg) concentration, patients were divided into 3 groups including hypomagnesemia (Mg2+ < 0. Read More

J Feline Med Surg 2019 12 29;21(12):1172-1180. Epub 2019 Jan 29.

Internal Medicine, School of Veterinary Medicine and Animal Science/University of Sao Paulo, Sao Paulo, Brazil.

Objectives: Magnesium has been 'the forgotten ion' for many years. Over the past decade, however, the role of magnesium in essential physiological functions and several illness conditions have been elucidated. Nevertheless, the investigation of magnesium in cats with chronic kidney disease (CKD) and nephrolithiasis is yet to be determined. Read More

Pflugers Arch 2019 06 26;471(6):901-914. Epub 2019 Jan 26.

Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Fahrstr. 17, D-91054, Erlangen, Germany.

Fibroblast growth factor 23 (FGF23) levels are elevated in patients with acute kidney injury (AKI). The consequences on renal Ca, Mg, and P regulatory mechanisms are unknown. We hypothesized that renal ischemia-reperfusion (I/R) injury alters the expression of important renal Ca, Mg, and P transport proteins. Read More

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Dec 18;46(6):370-379. Epub 2019 Jan 18.

Objective: To investigate the prevalence and etiology of an increased concentration of ionized magnesium (iMg) in dogs and to evaluate its prognostic relevance.

Materials And Methods: From April 2009 to December 2013, serum electrolytes were measured in 9950 dogs using an ion-selective electrode. Inclusion criterion was an iMg concentration ≥ 0. Read More

BMC Infect Dis 2018 Dec 27;18(1):698. Epub 2018 Dec 27.

The Rappaport's Faculty of Medicine, The Technion Institute, Haifa, Israel.

Background: Community acquired pneumonia (CAP) is a common illness affecting hundreds of millions worldwide. Few studies have investigated the relationship between serum magnesium levels and outcomes of these patients. We aimed to study the association between serum magnesium levels and 30-day mortality among patients with CAP. Read More

Intern Med 2019 Apr 18;58(8):1123-1126. Epub 2018 Dec 18.

Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Japan.

A 79-year-old Japanese woman presented with consciousness disturbance, hypercalcemia, and hypermagnesemia. She had rheumatoid arthritis and osteoporosis. Three months before admission, she was treated with oral calcitriol for osteoporosis. Read More

Caspian J Intern Med 2018 ;9(4):413-415

Department of Internal Medicine, Marshfield Clinic, Marshfield, USA.

Background: Generally, it is very rare for clinically significant hypermagnesemia to develop in an individual with normal renal functions as the renal handling of serum magnesium is a very potent process and it has the capacity, under conditions of hypermagnesemia, to completely block Mg (magnesium) reabsorption from the thick ascending limb of Henle. Therefore, hypermagnesemia usually arises in the setting of renal failure.

Case Presentation: We present a very rare case of a 40-year-old African American obese female with prior normal renal functions, who presented post-cardiac arrest following accidental overdose of Epsom salt. Read More

Am J Kidney Dis 2019 03 25;73(3):425-428. Epub 2018 Oct 25.

Division of Nephrology, Department of Pediatrics, NYU Langone Health, New York, NY. Electronic address:

Hypokalemia of renal origin can arise from genetic abnormalities in a variety of transporters or channel proteins that mediate tubular handling of potassium. Recently, mutations in claudin 10 have been documented in patients with hypokalemia in association with a range of other electrolyte abnormalities and skin and sweat gland manifestations. We report a 12-year-old Hispanic boy who presented with anhydrosis, aptyalism, alacrima, hypokalemia, and hypocalciuria, in whom we detected a homozygous mutation in the claudin 10 gene. Read More

Geriatr Gerontol Int 2018 09;18(9):1420-1421

Department of Internal Medicine, Aino Hospital, Osaka, Japan.

Acta Clin Belg 2019 Feb 17;74(1):41-47. Epub 2018 Sep 17.

a Renal Division, Department of Internal Medicine , Ghent University Hospital , Ghent , Belgium.

Magnesium is an essential element which also has pleiotropic effects in humans. Recent studies have altered our interpretation of a disturbed magnesium balance both leading to hypomagnesemia and hypermagnesemia. : a narrative review of their clinical relevance is presented. Read More

CEN Case Rep 2019 02 22;8(1):31-37. Epub 2018 Aug 22.

Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, Niigata, 951-8510, Japan.

Hypermagnesemia is generally considered an exceptional iatrogenic condition usually caused by magnesium-containing cathartics. In particular, this condition often develops when magnesium-containing cathartics are administered to elderly patients with renal insufficiency or bowel movement dysfunction. Although magnesium oxide (MgO) is widely prescribed as a laxative, serum magnesium concentration has not been examined in most cases. Read More

Contrib Nephrol 2018 24;196:58-63. Epub 2018 Jul 24.

Background: Despite the prognostic significance of mineral and bone disorders in patients undergoing hemodialysis, very few studies have focused on magnesium metabolism in this population. Nephrologists have paid much attention to hypermagnesemia, which is sometimes caused by magnesium administration, but the clinical implication of low magnesium has been largely overlooked. Recently, several cohort studies have reported that lower serum magnesium levels are associated with an increased risk of all-cause and cardiovascular mortality among hemodialysis patients. Read More

Acute Med Surg 2018 Jul 21;5(3):222-229. Epub 2018 Feb 21.

Department of Nephrology Kurashiki Central Hospital Kurashiki Japan.

Aim: This study aimed to clarify the characteristics of patients who presented with severe hypermagnesemia and subsequently underwent emergency hemodialysis.

Methods: We investigated the age, gender, complications, clinical symptoms, causal drugs, electrocardiogram findings, and laboratory data of 15 patients.

Results: Magnesium oxide had been administered in all cases and 14 patients were over 65 years old. Read More

Nutr Rev 2018 07;76(7):526-538

Center for Clinical and Translational Science, University of Vermont, Burlington, Vermont, USA.

The negative health effects of inadequate magnesium intake are well established, but the extent of the problem of deficiency warrants further exploration. This review explores the dietary factors, such as changes in agricultural practices and dietary patterns, that affect magnesium consumption over time and examines the current adequacy of magnesium intake among adults in the United States. Large, cross-sectional, population-based data sets confirm over half the adult population in the United States does not consume adequate amounts of magnesium, although recent population-based studies show a steady and consistent recovery in magnesium consumption over the last several decades. Read More

Adv Chronic Kidney Dis 2018 05;25(3):291-295

Centre for Nephrology, Royal Free Hospital, London, UK.

This article explores the effects of CKD and end-stage kidney disease on magnesium balance. In CKD, there is decreased glomerular filtration of magnesium. Decreased tubular reabsorption can compensate to a degree, but once CKD stage 4 is reached there is a tendency toward hypermagnesemia. Read More

Adv Chronic Kidney Dis 2018 05;25(3):267-273

Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA; and Division of Transplantation, Beth Israel Deaconess Medical Center, Boston, MA. Electronic address:

As with other electrolytes, magnesium homeostasis depends on the balance between gastrointestinal absorption and kidney excretion. Certain drugs used commonly in patients with CKD can decrease gastrointestinal ingestion and kidney reclamation, and potentially cause hypomagnesemia. Other magnesium-containing drugs such as laxatives and cathartics can induce hypermagnesemia, particularly in those with impaired glomerular filtration and magnesium excretion. Read More

J Vet Intern Med 2018 Jul 27;32(4):1359-1371. Epub 2018 Apr 27.

Department of Clinical Science and Services, Royal Veterinary College, University of London, London, United Kingdom.

Background: Hypomagnesemia is associated with increased mortality and renal function decline in humans with chronic kidney disease (CKD). Magnesium is furthermore inversely associated with fibroblast growth factor 23 (FGF23), an important prognostic factor in CKD in cats. However, the prognostic significance of plasma magnesium in cats with CKD is unknown. Read More

Am J Med Sci 2018 Apr 12;355(4):390-395. Epub 2017 Sep 12.

Tulane University School of Medicine, New Orleans, Louisiana.; Southeast Louisiana Veterans Healthcare System, New Orleans, Louisiana.. Electronic address:

We report a case of fatal hypermagnesemia in a 53-year-old woman admitted for acute exacerbation of chronic obstructive pulmonary disease and with a history of chronic constipation treated regularly with magnesium-containing laxatives. On admission, her magnesium level was 2.0mg/dL, which rose to a peak of 10. Read More

Support Care Cancer 2018 Aug 5;26(8):2809-2814. Epub 2018 Mar 5.

Department of Clinical & Administrative Pharmacy, University of Georgia College of Pharmacy, 1120 15th Street, HM 104, Augusta, GA, 30912, USA.

Purpose: Hematopoietic cell transplant (HCT) recipients often require intravenous (IV) magnesium repletion due to poor dietary intake, gastrointestinal loss, and use of concomitant magnesium wasting medications. Prolonging the IV magnesium infusion rate has been postulated to reduce renal clearance and improve retention; however, limited evidence supports this hypothesis.

Methods: We reviewed autologous and allogeneic HCT recipients (n = 82) who received IV magnesium at our institution between 2014 and 2016: 41 patients received IV magnesium at a prolonged rate of 0. Read More

BMC Pediatr 2018 02 13;18(1):55. Epub 2018 Feb 13.

Division of Neonatology, Kumamoto University Hospital, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Background: Neonatal nonoliguric hyperkalemia (NOHK) is a metabolic abnormality that occurs in extremely premature neonates at approximately 24 h after birth and is mainly due to the immature functioning of the sodium (Na)/potassium (K) pump. Magnesium sulfate is frequently used in obstetrical practice to prevent preterm labor and to treat preeclampsia; this medication can also cause hypermagnesemia and hyperkalemia by a mechanism that is different from that of NOHK. Herein, we report the first case of very early-onset neonatal hyperkalemia induced by maternal hypermagnesemia. Read More

J Crit Care 2018 04 11;44:419-423. Epub 2018 Jan 11.

Intensive Care Medicine, The University of Melbourne, Melbourne, Australia. Electronic address:

Background: Intravenous magnesium is routinely administered in intensive care units (ICU) to treat arrhythmias after cardiothoracic surgery. There are no data on the pharmacokinetics of continuous magnesium infusion therapy.

Objective: To investigate the pharmacokinetics of continuous magnesium infusion, focusing on serum and urinary magnesium concentration, volume of distribution and half-life. Read More