94 results match your criteria Hyperkeratosis of the Nipple and Areola
Dermatol Ther 2018 Apr 6:e12602. Epub 2018 Apr 6.
Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy.
Postepy Dermatol Alergol 2018 Feb 20;35(1):39-46. Epub 2018 Feb 20.
Department of Bone Marrow Transplantation and Onco-Hematology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Poland.
Introduction: The use of vemurafenib in melanoma has improved the survival of patients; however, it is associated with skin toxicities.
Aim: To assess skin toxicities by dermoscopy in patients treated with vemurafenib.
Material And Methods: Eight patients with BRAF V600 mutation positive metastatic melanoma were examined dermoscopically during vemurafenib treatment. Read More
Indian J Dermatol Venereol Leprol 2018 Mar 1. Epub 2018 Mar 1.
Department of Dermatology, Faculty of Medicine, Northern Borders University, Arar, Kingdom of Saudi Arabia.
Hyperkeratosis of the nipple and areola is a rare condition first described by Tauber in 1923. Less than 100 cases have been reported in the literature. Hyperkeratosis of the nipple and areola presents as hyperkeratotic, hyperpigmented plaques on the nipple and areola. Read More
Postgrad Med 2018 Apr 5;130(3):361-364. Epub 2018 Mar 5.
a Beijing Friendship Hospital , Capital Medical University , Beijing , China.
Hyperkeratosis of the nipple and areola is an uncommon dermatosis without well-defined etiology, which occurs mostly in young women and may only be a cosmetic problem. In 1938, Levy-Frankel classified this disease into three variants; type I involves hyperkeratosis with an epidermal nevus, and has rarely been reported. We report a case of a 23-year-old woman with long-term bilateral pigmentation and thickening of the nipples and areolae, accompanied with dark brown, flat lesions with a linear distribution on her left forearm. Read More
Dermatol Ther 2017 May 17;30(3). Epub 2017 Feb 17.
Department of Dermatology, Baylor Scott & White Health, Texas A&M Health Science Center College of Medicine, Temple, Texas, 76508.
Vemurafenib is a selected BRAF kinase inhibitor approved for treating metastatic or unresectable melanoma, which has numerous cutaneous side effects unfortunately, including three previously reported cases of asymptomatic areola and/or nipple hyperkeratosis. We present the first case of painful bilateral nipple hyperkeratosis secondary to vemurafenib in an 84-year-old woman. She was successfully treated with tretinoin 0. Read More
JAAD Case Rep 2016 Nov 7;2(6):500-501. Epub 2016 Dec 7.
Department of Clinical Medicine and Surgery, Section of Dermatology, University Federico II, Naples, Italy.
Int J Surg Case Rep 2016 22;28:117-120. Epub 2016 Sep 22.
Clinic of Plastic and Reconstructive Surgery, Department of Neurosciences, University of Padova, Via Giustiniani 2, 35128 Padova, Italy.
Introduction: Nevoid hyperkeratosis of the nipple and/or areola (NHNA) is a benign lesion with a female predominance and an aesthetically disturbing appearance. Spontaneous remission is not reported and medical treatments proposed so far have shown variable results.
Presentation Of Case: We describe a rare case of an extensive variant of NHNA covering almost the entire breasts' surface. Read More
Indian J Dermatol Venereol Leprol 2016 Nov-Dec;82(6):730-732
Department of Skin and V.D., Patna Medical College, Patna, Bihar, India.
Dermatol Online J 2016 Feb 17;22(2). Epub 2016 Feb 17.
Complejo Hospitalario Torrecardenas, Almeria.
A 25-year-old woman presented to our dermatology unit with progressive diffuse thickening of the both areolas. A skin biopsy was taken from the right areola showing irregular filiform acanthosis with elongation and anastomosis of rete ridges, irregular orthokeratotic hyperkeratosis, pseudocyst formation, and hyperpigmentation of the basal layer. The cause of nevoid hyperkeratosis of the nipple and areola is unknown. Read More
Pathology 2016 Jun 29;48(4):390-3. Epub 2016 Apr 29.
Department of Anatomical Pathology, PathWest, QEII Medical Centre, Perth, Australia; School of Pathology and Laboratory Medicine, University of Western Australia, Perth, WA, Australia. Electronic address:
Dermatopathology (Basel) 2015 Jul-Dec;2(3):61-6. Epub 2015 Nov 17.
Departments of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Nevoid hyperkeratosis of the nipple and areola (NHNA) is a rare clinicopathological entity showing persistent and strictly localized hyperkeratotic lesions of the nipple, areola or both with unknown etiopathogenesis. A similar clinical appearance may also be seen in different diseases with specific histopathological features. There are a few anecdotal reports on the association of NHNA with mycosis fungoides (MF), but they do not describe a uniform condition. Read More
J Hum Lact 2016 May 21;32(2):361-3. Epub 2016 Mar 21.
Austin Lactation Associates, Manchaca, TX, USA
Unusual conditions of the nipple and breast may interfere with breastfeeding. Nevi of the nipple are rare, and breastfeeding outcomes of women with this condition have only been briefly reported in the literature. This case describes the proactive lactation management and successful breastfeeding outcome of a woman with a large, roughly textured nevus located on her right nipple and areola. Read More
Am J Dermatopathol 2015 Aug;37(8):621-2, 659
*Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, MA; †Department of Dermatology, Boston University, Boston, MA; and ‡Department of Dermatology, Boston University School of Medicine, Boston, MA.
Turk J Pediatr 2014 Sep-Oct;56(5):565-7
Department of Dermatology, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey; Clinic of Dermatology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Mycosis fungoides is one of the great imitators in dermatology; it can mimic many dermatoses. Nevoid hyperkeratosis of the nipple and areola is a rare idiopathic disease with typical clinical features of verrucous thickening and brownish discoloration of the nipple, areola or both. Here, a 16-year-old male patient with mycosis fungoides mimicking nevoid hyperkeratosis of the nipple and areola has been reported. Read More
Clin Exp Dermatol 2016 Mar 22;41(2):148-51. Epub 2015 Feb 22.
Dorset County Hospital, Dorchester, UK.
We present a rare condition, hyperkeratosis of the areola, induced by vemurafenib. Only a few papers have described an association of BRAF inhibitors with hyperkeratosis of the areola and/or nipple. Vemurafenib is a selective BRAF inhibitor used in patients with unresectable or metastatic melanoma who are positive for the V600 mutation. Read More
Int J Dermatol 2015 Jan 14;54(1):e47-8. Epub 2014 Oct 14.
Department of Dermatology, Jundishapur University of Medical Sciences, Ahvaz, Iran.
Clin Exp Dermatol 2015 Jan 23;40(1):23-6. Epub 2014 Sep 23.
Davao Doctors Hospital, Davao City, Philippines; Imperial College School of Medicine, London, UK.
Few cases of naevoid hyperkeratosis of the nipple and areola (NHNA) have been documented since the condition was first described in 1923. A recent PubMed search (Mar 2014) yielded 107 cases of NHNA in the world literature, mostly female patients with adolescent-onset disease. We report the first two cases of adolescent-onset NHNA from the Philippines. Read More
Dermatol Pract Concept 2014 Jul 31;4(3):81-4. Epub 2014 Jul 31.
Skin Cancer Unit, Arcispedale Santa Maria Nuova- IRCCS, Reggio Emilia, Italy ; Department of Dermatology, Medical University of Graz; Graz, Austria.
Background: Acanthosis nigricans (AN) develops sporadically or in association with obesity, insulin-resistance and dark pigmentary phenotype. Unusual clinical presentations of AN may be diagnostically vexing.
Objectives: The aim of the report is to present unusual clinical and dermoscopic pictures of hyper-keratotic, brownish lesions of the nipples resembling acanthosis nigricans. Read More
J Eur Acad Dermatol Venereol 2015 Jan 14;29(1):7-13. Epub 2014 Aug 14.
Department of Plastic and Reconstructive Surgery, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.
Background: Benign lesions of the breast in total are much more frequent than malignant ones. However, there are no epidemiologic data on the prevalence of benign or malignant tumours of the nipple, and the bibliography on benign nipple tumours in general is limited.
Aims: To present some rare cases of benign nipple tumours and review the literature. Read More
J Eur Acad Dermatol Venereol 2015 Jan 24;29(1):61-8. Epub 2014 Mar 24.
Department of Dermatology, University Hospitals Leuven, Leuven, Belgium.
Background: BRAF inhibitors frequently cause significant cutaneous adverse reactions.
Objective: To study the timing, prevalence and response to treatment of skin lesions in patients receiving V-raf murine sarcoma viral oncogene homolog B1 (BRAF) inhibitors.
Methods: We prospectively studied the cutaneous side-effects of patients with a BRAF mutant (V600E, V600K, V600R) metastatic malignant melanoma treated with a BRAF inhibitor. Read More
J Am Acad Dermatol 2014 Apr;70(4):e84-5
American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:
Indian J Dermatol Venereol Leprol 2014 Jan-Feb;80(1):78-80
Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Indian J Dermatol 2013 Sep;58(5):408
Department of Dermatopathology, Autoimmune Bullous Diseases Research Center, Razi Skin Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Nevoid hyperkeratosis of the nipple and/or areola (NHNA) is a rare and benign disease, with poorly understood etiology and no definite therapeutic plan. Hereby, we report another case of NHNA, discuss about its clinical and histopathological features, differential diagnosis, and responsiveness to topical steroid. Read More
JAMA Dermatol 2013 Jun;149(6):722-6
Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Importance: Reported physiologic nipple changes in pregnancy do not include hyperkeratosis and are expected to resolve or improve post partum. Hyperkeratosis of the nipple and/or areola can develop in the context of inflammatory diseases (such as atopic dermatitis), in acanthosis nigricans, as an extension of epidermal nevus, after estrogen treatment, and/or in nevoid hyperkeratosis of the nipple and areola. We performed a clinicopathologic analysis of cases of pregnancy-associated nipple hyperkeratosis. Read More
J Cutan Aesthet Surg 2012 Jan;5(1):40-2
Plastic Surgery Unit, Iaso Private Hospital, Athens, Greece.
Nevoid hyperkeratosis of the breast is a rare condition affecting the nipple, the areola or both. It appears in both sexes and it can by lateral or unilateral. It can also accompany other skin diseases or systemic conditions including malignancies. Read More
J Cutan Pathol 2012 May;39(5):545-8
Division of Dermatology, Washington University School of Medicine, St. Louis, MO, USA.
Nevoid hyperkeratosis of the nipple and areola is a benign condition with fewer than 70 cases reported in the literature. We report a case of unilateral nevoid hyperkeratosis of the areola with intraepidermal lymphocytes that resembled Pautrier's microabscesses on histological examination. This is the third report of mycosis fungoides-like changes in nevoid hyperkeratosis of the nipple and areola. Read More
J Cutan Aesthet Surg 2011 Sep;4(3):214-5
Department of Dermatology and STD, University College of Medical Sciences and Associated Guru Teg Bahadur Hospital (University of Delhi), Shahdara, New Delhi, India E-mail:
Acta Dermatovenerol Alp Pannonica Adriat 2011 ;20(1):41-3
Department of Dermatology, Farhat Hached Academic Hospital, Sousse, Tunisia.
Hyperkeratosis of the nipple and areola (HNA) is an unusual dermatosis that Levy-Franckel classified into three variants (1). This rare condition occurs primarily in young women and represents a cosmetic problem. Furthermore, its management is a therapeutic challenge. Read More
J Dtsch Dermatol Ges 2011 Dec 9;9(12):1004-9. Epub 2011 Jun 9.
Department of Dermatology and Allergy, University Clinic Gießen and Marburg, Marburg, Germany.
The male nipple-areola-complex (NAC) is a residual organ without physiologic functions in the male. It possesses similar hormone sensitivity and sexual sensitivity as the female organ. The location of the NAC on the chest wall with respect to other surface features is relevant for the male appearance. Read More
N Engl J Med 2010 Apr;362(17):1618
Habib Thameur Hospital, Tunis, Tunisia.
Dig Liver Dis 2009 Aug 19;41(8):611. Epub 2009 Mar 19.
Am J Med Genet A 2008 Oct;146A(20):2657-62
Unité de Génétique Médicale, Faculté de Médecine, Université Saint-Joseph, Beirut, Lebanon.
We report on an 18-year-old woman, born to first-cousin parents, presenting with a severe form of anhydrotic ectodermal dysplasia (EDA/HED). She had sparse hair, absent limb hair, absent sweating, episodes of hyperpyrexia, important hypodontia, and hyperconvex nails. She also showed unusual clinical manifestations such as an absence of breasts, a rudimentary extranumerary areola and nipple on the left side, and marked palmo-plantar hyperkeratosis. Read More
Ann Dermatol Venereol 2008 Aug-Sep;135(8-9):571-4. Epub 2008 May 23.
Service de dermatologie, hôpital Porte-Madeleine, CHR d'Orléans, B.P. 82439, 45032 Orléans cedex 1, France.
Background: Leiomyoma of the nipple and areola is a rare benign neoplasm. We report the case of a patient with leiomyoma of the nipple presenting as a hyperkeratotic plaque.
Observation: A 23-year-old patient presented with a five year history of a papillomatous, hyperkeratotic, painful plaque originating in her right nipple. Read More
J Dermatolog Treat 2008 ;19(6):337-40
Dermatology Clinic, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Hyperkeratosis of the nipple and areola is a rare disorder characterized by verrucous thickening and brown pigmentation of the nipple and areola with unknown etiology. Although it is a generally asymptomatic disorder, cosmetic disfiguring creates a real psychological problem for young women. Moreover, treatment regimens are not satisfactory. Read More
Actas Dermosifiliogr 2008 Jul-Aug;99(6):500-1
Indian J Dermatol Venereol Leprol 2006 Sep-Oct;72(5):384-6
Indian J Dermatol Venereol Leprol 2006 Jul-Aug;72(4):303-5
Deparment of Skin and STD, J. S. S. Hospital, Mysore, Karnataka, India.
Nevoid hyperkeratosis of the nipple and areola is an unusual condition. Two female patients aged 31 and 18 years presented with chronic unilateral warty lesions of the nipple. One patient had difficulty in breastfeeding from the affected side. Read More
Breast J 2006 Jul-Aug;12(4):383-4
Department of General Surgery, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
J Dermatol 2006 Jul;33(7):510-1
An Pediatr (Barc) 2006 Feb;64(2):180-1
Clin Exp Dermatol 2005 Nov;30(6):721-2
Dermatol Surg 2005 Jun;31(6):703-5
Department of Plastic and Reconstructive Surgery, Erciyes University, Kayseri, Turkey.
Background: Nevoid hyperkeratosis of the nipple and areola (NHNA) is a rare condition of unknown etiology. Verrucous thickening and pigmentation of the nipple and areola are the main features of the condition. Different therapeutic options, both medical and surgical, have been described. Read More
Dermatol Surg 2005 May;31(5):611-2
Ann Plast Surg 2005 Jun;54(6):667-9
Department of Plastic and Reconstructive Surgery, University Hospital Dubrava, Zagreb, Croatia.
Hyperkeratosis of the nipple and areola is a rare, sporadic, benign condition characterized by verrucosus thickening and brownish discoloration of the nipple and areola. Approximately 50 cases of hyperkeratosis of the nipple and areola have been reported in the literature. Dermatologists treated most of them conservatively. Read More
J Am Acad Dermatol 2005 Mar;52(3 Pt 1):529-30
Ann Plast Surg 2004 Nov;53(5):510-2
Department of Plastic and Reconstructive Surgery, Radcliffe Infirmary, Oxford, United Kingdom.
The case is presented of a 29-year-old female who, at the age of 13 years, developed bilateral verrucous thickening of her areolae. Despite the condition causing her significant psychosocial morbidity, a specialist referral was initially denied on the grounds that no treatment was apparently available. The condition progressively deteriorated over the subsequent 14 years. Read More
Acta Derm Venereol 2003 ;83(5):385-6
J Eur Acad Dermatol Venereol 2003 Mar;17(2):232-3