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    89 results match your criteria Hyperkeratosis of the Nipple and Areola

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    Painful nipple hyperkeratosis secondary to vemurafenib.
    Dermatol Ther 2017 Feb 17. Epub 2017 Feb 17.
    Department of Dermatology, Baylor Scott & White Health, Texas A&M Health Science Center College of Medicine, Temple, Texas, 76508.
    Vemurafenib is a selected BRAF kinase inhibitor approved for treating metastatic or unresectable melanoma, which has numerous cutaneous side effects unfortunately, including three previously reported cases of asymptomatic areola and/or nipple hyperkeratosis. We present the first case of painful bilateral nipple hyperkeratosis secondary to vemurafenib in an 84-year-old woman. She was successfully treated with tretinoin 0. Read More

    Radical treatment of extensive nevoid hyperkeratosis of the areola and breast with surgical excision after mild response to topical agents: A case report.
    Int J Surg Case Rep 2016 22;28:117-120. Epub 2016 Sep 22.
    Clinic of Plastic and Reconstructive Surgery, Department of Neurosciences, University of Padova, Via Giustiniani 2, 35128 Padova, Italy.
    Introduction: Nevoid hyperkeratosis of the nipple and/or areola (NHNA) is a benign lesion with a female predominance and an aesthetically disturbing appearance. Spontaneous remission is not reported and medical treatments proposed so far have shown variable results.

    Presentation Of Case: We describe a rare case of an extensive variant of NHNA covering almost the entire breasts' surface. Read More

    Nevoid hyperkeratosis of the nipple and the areola.
    Dermatol Online J 2016 Feb 17;22(2). Epub 2016 Feb 17.
    Complejo Hospitalario Torrecardenas, Almeria.
    A 25-year-old woman presented to our dermatology unit with progressive diffuse thickening of the both areolas. A skin biopsy was taken from the right areola showing irregular filiform acanthosis with elongation and anastomosis of rete ridges, irregular orthokeratotic hyperkeratosis, pseudocyst formation, and hyperpigmentation of the basal layer. The cause of nevoid hyperkeratosis of the nipple and areola is unknown. Read More

    The Dilemma of Coexisting Nevoid Hyperkeratosis of the Nipple and Areola in Mycosis Fungoides: A Report of Three Cases.
    Dermatopathology (Basel) 2015 Jul-Dec;2(3):61-6. Epub 2015 Nov 17.
    Departments of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
    Nevoid hyperkeratosis of the nipple and areola (NHNA) is a rare clinicopathological entity showing persistent and strictly localized hyperkeratotic lesions of the nipple, areola or both with unknown etiopathogenesis. A similar clinical appearance may also be seen in different diseases with specific histopathological features. There are a few anecdotal reports on the association of NHNA with mycosis fungoides (MF), but they do not describe a uniform condition. Read More

    Successful Breastfeeding Outcome of a Woman with a Nevus of the Nipple: A Case Study.
    J Hum Lact 2016 May 21;32(2):361-3. Epub 2016 Mar 21.
    Austin Lactation Associates, Manchaca, TX, USA
    Unusual conditions of the nipple and breast may interfere with breastfeeding. Nevi of the nipple are rare, and breastfeeding outcomes of women with this condition have only been briefly reported in the literature. This case describes the proactive lactation management and successful breastfeeding outcome of a woman with a large, roughly textured nevus located on her right nipple and areola. Read More

    Dark Brown Plaques and Patches on the Breast and Areola in a 14-Year-Old Female. Nevoid hyperkeratosis of the areola and breast.
    Am J Dermatopathol 2015 Aug;37(8):621-2, 659
    *Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, MA; †Department of Dermatology, Boston University, Boston, MA; and ‡Department of Dermatology, Boston University School of Medicine, Boston, MA.

    Mycosis fungoides mimicking nevoid hyperkeratosis of the nipple and areola in an adolescent.
    Turk J Pediatr 2014 Sep-Oct;56(5):565-7
    Department of Dermatology, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey; Clinic of Dermatology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
    Mycosis fungoides is one of the great imitators in dermatology; it can mimic many dermatoses. Nevoid hyperkeratosis of the nipple and areola is a rare idiopathic disease with typical clinical features of verrucous thickening and brownish discoloration of the nipple, areola or both. Here, a 16-year-old male patient with mycosis fungoides mimicking nevoid hyperkeratosis of the nipple and areola has been reported. Read More

    Vemurafenib-induced hyperkeratosis of the areola treated with topical adapelene.
    Clin Exp Dermatol 2016 Mar 22;41(2):148-51. Epub 2015 Feb 22.
    Dorset County Hospital, Dorchester, UK.
    We present a rare condition, hyperkeratosis of the areola, induced by vemurafenib. Only a few papers have described an association of BRAF inhibitors with hyperkeratosis of the areola and/or nipple. Vemurafenib is a selective BRAF inhibitor used in patients with unresectable or metastatic melanoma who are positive for the V600 mutation. Read More

    Naevoid hyperkeratosis of the nipple and areola: an extensive form in two adolescent Filipino females.
    Clin Exp Dermatol 2015 Jan 23;40(1):23-6. Epub 2014 Sep 23.
    Davao Doctors Hospital, Davao City, Philippines; Imperial College School of Medicine, London, UK.
    Few cases of naevoid hyperkeratosis of the nipple and areola (NHNA) have been documented since the condition was first described in 1923. A recent PubMed search (Mar 2014) yielded 107 cases of NHNA in the world literature, mostly female patients with adolescent-onset disease. We report the first two cases of adolescent-onset NHNA from the Philippines. Read More

    "Neglected nipples": acanthosis nigricans-like plaques caused by avoidance of nipple cleansing.
    Dermatol Pract Concept 2014 Jul 31;4(3):81-4. Epub 2014 Jul 31.
    Skin Cancer Unit, Arcispedale Santa Maria Nuova- IRCCS, Reggio Emilia, Italy ; Department of Dermatology, Medical University of Graz; Graz, Austria.
    Background: Acanthosis nigricans (AN) develops sporadically or in association with obesity, insulin-resistance and dark pigmentary phenotype. Unusual clinical presentations of AN may be diagnostically vexing.

    Objectives: The aim of the report is to present unusual clinical and dermoscopic pictures of hyper-keratotic, brownish lesions of the nipples resembling acanthosis nigricans. Read More

    Rare benign tumours of the nipple.
    J Eur Acad Dermatol Venereol 2015 Jan 14;29(1):7-13. Epub 2014 Aug 14.
    Department of Plastic and Reconstructive Surgery, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.
    Background: Benign lesions of the breast in total are much more frequent than malignant ones. However, there are no epidemiologic data on the prevalence of benign or malignant tumours of the nipple, and the bibliography on benign nipple tumours in general is limited.

    Aims: To present some rare cases of benign nipple tumours and review the literature. Read More

    Cutaneous adverse effects of BRAF inhibitors in metastatic malignant melanoma, a prospective study in 20 patients.
    J Eur Acad Dermatol Venereol 2015 Jan 24;29(1):61-8. Epub 2014 Mar 24.
    Department of Dermatology, University Hospitals Leuven, Leuven, Belgium.
    Background: BRAF inhibitors frequently cause significant cutaneous adverse reactions.

    Objective: To study the timing, prevalence and response to treatment of skin lesions in patients receiving V-raf murine sarcoma viral oncogene homolog B1 (BRAF) inhibitors.

    Methods: We prospectively studied the cutaneous side-effects of patients with a BRAF mutant (V600E, V600K, V600R) metastatic malignant melanoma treated with a BRAF inhibitor. Read More

    Nevoid Hyperkeratosis of the Nipple and/or Areola: Treatment with Topical Steroid.
    Indian J Dermatol 2013 Sep;58(5):408
    Department of Dermatopathology, Autoimmune Bullous Diseases Research Center, Razi Skin Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
    Nevoid hyperkeratosis of the nipple and/or areola (NHNA) is a rare and benign disease, with poorly understood etiology and no definite therapeutic plan. Hereby, we report another case of NHNA, discuss about its clinical and histopathological features, differential diagnosis, and responsiveness to topical steroid. Read More

    Pregnancy-associated hyperkeratosis of the nipple: a report of 25 cases.
    JAMA Dermatol 2013 Jun;149(6):722-6
    Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
    Importance: Reported physiologic nipple changes in pregnancy do not include hyperkeratosis and are expected to resolve or improve post partum. Hyperkeratosis of the nipple and/or areola can develop in the context of inflammatory diseases (such as atopic dermatitis), in acanthosis nigricans, as an extension of epidermal nevus, after estrogen treatment, and/or in nevoid hyperkeratosis of the nipple and areola. We performed a clinicopathologic analysis of cases of pregnancy-associated nipple hyperkeratosis. Read More

    Surgical approach for nevoid hyperkeratosis of the areola.
    J Cutan Aesthet Surg 2012 Jan;5(1):40-2
    Plastic Surgery Unit, Iaso Private Hospital, Athens, Greece.
    Nevoid hyperkeratosis of the breast is a rare condition affecting the nipple, the areola or both. It appears in both sexes and it can by lateral or unilateral. It can also accompany other skin diseases or systemic conditions including malignancies. Read More

    Nevoid hyperkeratosis of the areola misinterpreted as mycosis fungoides.
    J Cutan Pathol 2012 May;39(5):545-8
    Division of Dermatology, Washington University School of Medicine, St. Louis, MO, USA.
    Nevoid hyperkeratosis of the nipple and areola is a benign condition with fewer than 70 cases reported in the literature. We report a case of unilateral nevoid hyperkeratosis of the areola with intraepidermal lymphocytes that resembled Pautrier's microabscesses on histological examination. This is the third report of mycosis fungoides-like changes in nevoid hyperkeratosis of the nipple and areola. Read More

    Bilateral idiopathic hyperkeratosis of the nipple and areola.
    Acta Dermatovenerol Alp Pannonica Adriat 2011 ;20(1):41-3
    Department of Dermatology, Farhat Hached Academic Hospital, Sousse, Tunisia.
    Hyperkeratosis of the nipple and areola (HNA) is an unusual dermatosis that Levy-Franckel classified into three variants (1). This rare condition occurs primarily in young women and represents a cosmetic problem. Furthermore, its management is a therapeutic challenge. Read More

    Diseases of the male nipple and areola.
    J Dtsch Dermatol Ges 2011 Dec 9;9(12):1004-9. Epub 2011 Jun 9.
    Department of Dermatology and Allergy, University Clinic Gießen and Marburg, Marburg, Germany.
    The male nipple-areola-complex (NAC) is a residual organ without physiologic functions in the male. It possesses similar hormone sensitivity and sexual sensitivity as the female organ. The location of the NAC on the chest wall with respect to other surface features is relevant for the male appearance. Read More

    Unusual presentation of a severe autosomal recessive anhydrotic ectodermal dysplasia with a novel mutation in the EDAR gene.
    Am J Med Genet A 2008 Oct;146A(20):2657-62
    Unité de Génétique Médicale, Faculté de Médecine, Université Saint-Joseph, Beirut, Lebanon.
    We report on an 18-year-old woman, born to first-cousin parents, presenting with a severe form of anhydrotic ectodermal dysplasia (EDA/HED). She had sparse hair, absent limb hair, absent sweating, episodes of hyperpyrexia, important hypodontia, and hyperconvex nails. She also showed unusual clinical manifestations such as an absence of breasts, a rudimentary extranumerary areola and nipple on the left side, and marked palmo-plantar hyperkeratosis. Read More

    [Hyperkeratotic lesion of the nipple revealing cutaneous leiomyoma].
    Ann Dermatol Venereol 2008 Aug-Sep;135(8-9):571-4. Epub 2008 May 23.
    Service de dermatologie, hôpital Porte-Madeleine, CHR d'Orléans, B.P. 82439, 45032 Orléans cedex 1, France.
    Background: Leiomyoma of the nipple and areola is a rare benign neoplasm. We report the case of a patient with leiomyoma of the nipple presenting as a hyperkeratotic plaque.

    Observation: A 23-year-old patient presented with a five year history of a papillomatous, hyperkeratotic, painful plaque originating in her right nipple. Read More

    Hyperkeratosis of the nipple and areola: 2 years of remission with low-dose acitretin and topical calcipotriol therapy.
    J Dermatolog Treat 2008 ;19(6):337-40
    Dermatology Clinic, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
    Hyperkeratosis of the nipple and areola is a rare disorder characterized by verrucous thickening and brown pigmentation of the nipple and areola with unknown etiology. Although it is a generally asymptomatic disorder, cosmetic disfiguring creates a real psychological problem for young women. Moreover, treatment regimens are not satisfactory. Read More

    Unilateral nevoid hyperkeratosis of the nipple: a report of two cases.
    Indian J Dermatol Venereol Leprol 2006 Jul-Aug;72(4):303-5
    Deparment of Skin and STD, J. S. S. Hospital, Mysore, Karnataka, India.
    Nevoid hyperkeratosis of the nipple and areola is an unusual condition. Two female patients aged 31 and 18 years presented with chronic unilateral warty lesions of the nipple. One patient had difficulty in breastfeeding from the affected side. Read More

    Treatment of nevoid hyperkeratosis of the nipple and areola using a radiofrequency surgical unit.
    Dermatol Surg 2005 Jun;31(6):703-5
    Department of Plastic and Reconstructive Surgery, Erciyes University, Kayseri, Turkey.
    Background: Nevoid hyperkeratosis of the nipple and areola (NHNA) is a rare condition of unknown etiology. Verrucous thickening and pigmentation of the nipple and areola are the main features of the condition. Different therapeutic options, both medical and surgical, have been described. Read More

    Surgical treatment of nevoid hyperkeratosis of the areola by removal of the areola and reconstruction with a skin graft.
    Ann Plast Surg 2005 Jun;54(6):667-9
    Department of Plastic and Reconstructive Surgery, University Hospital Dubrava, Zagreb, Croatia.
    Hyperkeratosis of the nipple and areola is a rare, sporadic, benign condition characterized by verrucosus thickening and brownish discoloration of the nipple and areola. Approximately 50 cases of hyperkeratosis of the nipple and areola have been reported in the literature. Dermatologists treated most of them conservatively. Read More

    Treatment of nevoid hyperkeratosis of the nipple and areola by shave excision.
    Ann Plast Surg 2004 Nov;53(5):510-2
    Department of Plastic and Reconstructive Surgery, Radcliffe Infirmary, Oxford, United Kingdom.
    The case is presented of a 29-year-old female who, at the age of 13 years, developed bilateral verrucous thickening of her areolae. Despite the condition causing her significant psychosocial morbidity, a specialist referral was initially denied on the grounds that no treatment was apparently available. The condition progressively deteriorated over the subsequent 14 years. Read More

    Nevoid hyperkeratosis of the nipple and areola: a distinct entity.
    J Am Acad Dermatol 2002 Mar;46(3):414-8
    Department of Dermatology, Istanbul University, Istanbul Medical School, 34390-Capa, Istanbul, Turkey.
    Although nevoid hyperkeratosis of the nipple and areola was initially described in 1923, there are only case reports or reviews about it; no large series have been documented to date. The clinical features of the reported cases in the literature are not uniform, and it is questioned whether nevoid hyperkeratosis of the nipple and areola is a distinct clinicopathologic entity or a clinical presentation of various dermatoses. We describe 7 cases with hyperkeratotic nevoid lesions localized on the nipple and areola with different clinical features. Read More

    Nevoid hyperkeratosis of the areola with histopathological features mimicking mycosis fungoides.
    Eur J Dermatol 2002 Jan-Feb;12(1):79-81
    Department of Dermatology, Clínica Universitaria Puerta de Hierro, Madrid, Spain.
    Hyperkeratosis of the areola is a rare benign condition of unknown etiology characterized by slowly growing verrucous thickening and brown pigmentation of the areola or/and the nipple. It may be presented as isolated nevoid form or associated with other skin diseases. We described a 21-year-old woman with characteristic lesions of nevoid hyperkeratosis in both areolas but with histopathological findings resembling mycosis fungoides. Read More

    Nevoid hyperkeratosis of the nipple and areola: treatment of two patients with topical calcipotriol.
    J Am Acad Dermatol 2002 Jan;46(1):131-3
    Department of Dermatology, Kocaeli University School of Medicine, Izmit, Turkey.
    Nevoid hyperkeratosis of the nipple and areola, which is characterized by verrucous thickening and pigmentation of the nipple or areola, is a rare condition. Different therapeutic options have been used with varying results, but there is no uniformly effective treatment. We describe two patients with hyperkeratosis of the nipple and areola who responded well to topical calcipotriol ointment. Read More

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