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Scand J Immunol 2018 Dec 13:e12742. Epub 2018 Dec 13.

Pharmicell Co, Ltd, 484, Dunchon-daero, Jungwon-gu, Seongnam, Gyeonggi-do, Korea.

Myeloid-derived suppressor cells (MDSCs) play an important role in controlling the immune response against cancer and in suppression of autoimmunity and allergic inflammation. However, the beneficial effects of MDSCs on the experimental mouse model of psoriasis have not been reported. Therefore, we investigated the anti-psoriatic effect of MDSCs on IMQ-induced skin inflammation in mice and explored the mechanisms involved. Read More

Acta Paediatr 2018 Dec 11. Epub 2018 Dec 11.

Fundación Pública Galega de Medicina Xenómica-SERGAS, CIBERER, IDIS, Grupo de Medicina Xenómica-Universidade de Santiago de Compostela, Santiago de CompostelaSpain.

Ichthyosis prematurity syndrome (IPS), or ichthyosis congenita type IV, is a rare syndromic form of autosomic recessive ichthyosis caused by mutations in fatty acid transport protein 4 (FATP4), also known as SLC27A4. Patients with a disrupted FATP4 gene are usually born prematurely with thick desquamating skin and other complications, such as neonatal asphyxia, eosinophilia and elevated serum immunoglobulin E levels. Symptoms become less severe after the first months of life, evolving to non-scaly ichthyosis with follicular hyperkeratosis in adulthood (1, 2). Read More

Cutan Ocul Toxicol 2018 Dec 2:1-17. Epub 2018 Dec 2.

a Department of Pharmacy , Renmin Hospital of Wuhan University , Wuhan , Hubei , 430060 , P.R. China.

Background: This meta-analysis was conducted to assess the risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients.

Methods: We considered relevant prospective randomized Phase I, II and III trials of melanoma patients on the combined BRAF and MEK inhibition versus BRAF inhibition, describing events of rash, photosensitivity reaction (PR), hyperkeratosis (HK), alopecia, cutaneous squamous-cell carcinom(cSCC), skin papilloma(SP), pruritus and hand-foot syndrome(HFS), as eligible for inclusion.

Results: Eight trials comprising 3163 patients were included in the meta-analysis. Read More

Int J Dermatol 2018 Dec 4. Epub 2018 Dec 4.

Department of Dermatology, Hospital Universitario 12 de Octubre, I+12 Research Institute, Universidad Complutense, Madrid, Spain.

Case Rep Oncol 2018 Sep-Dec;11(3):660-664. Epub 2018 Oct 23.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Pigmented breast cancer in the skin caused by nonneoplastic melanocytes of epidermal origin is a rare condition of metastasis from breast cancer, but the pathogenesis of this phenomenon is almost unknown. In this report, we describe a case of breast cancer metastasis in the skin with prominent hyperkeratotic pigmentation caused by nonneoplastic melanocyte colonization. Immunohistochemical staining revealed that the metastatic tumor cells produced IL-23, which is reported not only to induce IL-17 but also to inhibit cell apoptosis in breast cancer cells, which affects tumor progression. Read More

Int J Dermatol 2018 Nov 27. Epub 2018 Nov 27.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

Background: Reports regarding squamous cell carcinoma of the nail unit (SCCnu) are rare in Asia.

Objectives: To investigate the features of SCCnu in the Asian population.

Method: We performed a retrospective review of patients diagnosed with SCCnu at our institution between 2012 and 2017. Read More

J Eur Acad Dermatol Venereol 2018 Nov 25. Epub 2018 Nov 25.

Dermatology, Department of Specialized, Diagnostic and Experimental Medicine, University of Bologna, Bologna, Italy.

Background: Frontal fibrosing alopecia (FFA) is increasing in prevalence worldwide and several series from different countries have been published, in order to detect possible causes of the disease outbreak.

Objective: To analyze the epidemiological, clinical and trichoscopic features of FFA seen in an Italian Dermatology Unit.

Methods: Clinical, trichoscopy, histopathology and medical details of all patients were compared with literature and general population data. Read More

J Eur Acad Dermatol Venereol 2018 Nov 23. Epub 2018 Nov 23.

Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.

Background: B-rapidly accelerated fibrosarcoma (BRAF) inhibitor encorafenib alone and in combination with MEK inhibitor binimetinib improves survival in BRAF-mutated melanoma patients. So far, the range of cutaneous adverse events has been characterized only for established BRAF inhibitors (vemurafenib, dabrafenib) and MEK inhibitors (trametinib, cobimetinib).

Objective: The aim of this study was to investigate cutaneous adverse events emerging in melanoma patients treated with encorafenib and binimetinib. Read More

Am J Dermatopathol 2018 Nov 15. Epub 2018 Nov 15.

Section of Dermatology, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

Nevus comedonicus is a rare cutaneous follicular hamartoma, characterized by the clustering of papules with firm, blackened horny buffers. It is usually present at birth or during childhood, although few cases of late-onset disease have been described. We present a case of postmenopausal-onset nevus comedonicus in a 55-year-old white woman without relevant medical history. Read More

Otolaryngol Pol 2018 Aug;72(5):17-23

Department of Otolaryngology, Head and Neck Surgery, Poznań University of Medical Sciences, Poznań, Poland.

Introduction: Treatment planning in T2, T3 laryngeal carcinoma is based on clinical assessment and radiological imaging. However, to delineate precise mucosal margins for transoral laser microsurgery (TLM), a high class, sophisticated endoscopy is indispensable. Narrowband imaging (NBI) which is an optical filter technology, seems to be a useful adjunctive tool in marking superficial margins. Read More

Br J Dermatol 2018 Nov 19. Epub 2018 Nov 19.

Dermatology and Genetic Medicine, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.

Punctate palmoplantar keratoderma (PPPK) is a rare, autosomal dominant disorder of keratinization with three main variants. PPPK type 1 (MIM 148600), also known as Buschke-Fischer-Brauer disease, is characterized by the progressive development of multiple small hyperkeratotic papules with central indentations that are irregularly distributed on the palms and soles, often deteriorating to more extensive diffuse hyperkeratosis on the weight-bearing areas of plantar skin. The PPPK1 gene was recently identified as the α and γ-adaptin binding protein p34 gene AAGAB, and in a single case, the COL14A1 gene. Read More

Sensors (Basel) 2018 Nov 14;18(11). Epub 2018 Nov 14.

Hochschule Neubrandenburg, Department of Agricultural Machinery, University of Applied Science, Brodaer Straße 2, 17033 Neubrandenburg, Germany.

The aim of this study was to evaluate whether the severity of hyperkeratosis (HK) in the teats of dairy cows can be assessed by a dielectric measurement. The study focused on surveying the occurrence of hyperkeratosis in a total of 241 teats of lactating dairy cows. A scoring system consisting of four categories was used to macroscopically assess the severity of HK. Read More

Spec Care Dentist 2018 Nov 15. Epub 2018 Nov 15.

Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, Florida.

The development of dysplastic changes in oral epithelial lesions is a potential long-term complication after hematopoietic stem cell transplantation (HSCT). This may be related to mechanisms including radiation and chemotherapy regimens, chronic graft-versus-host disease (cGVHD), inflammation, and prolonged immunosuppression. The current case describes a 54-year-old male with multiple myeloma treated by autologous and allogenic HSCT followed by development of cGVHD (mouth, skin and the eyes) with the complaint of diffuse white lesions on the buccal mucosa, tongue, and palate. Read More

Australas J Dermatol 2018 Nov 15. Epub 2018 Nov 15.

Servicio de Dermatología, Hospital Universitario Virgen de las Nieves, Granada, Spain.

Background/objectives: Frontal fibrosing alopecia (FFA) is a scarring alopecia whose prevalence is increasing. The pathogenesis of this disease is not well known. Genetic, environmental, hormonal and autoimmunity related factors have been considered; however, only a few cases of familial frontal fibrosing alopecia have been reported. Read More

Arthritis Rheumatol 2018 Nov 14. Epub 2018 Nov 14.

Corporal Michael J. Crescenz VAMC, Philadelphia, Pennsylvania, USA.

A 77-year old Caucasian woman presented with a 10-year history of discoid, scaly, pigmented, telangiectatic and atrophic patches on the upper cheeks (Figure 1), and gradually progressive alopecia of the frontal scalp (Figure 2). A biopsy of the cheek demonstrated interface dermatitis, epidermal hyperkeratosis and atrophy, dyskeratotic keratinocytes, and a superficial perivascular lymphohistiocytic infiltrate with pigment incontinence. She had a low-titer ANA (1:80, nucleolar), negative SS-A and SS-B, and unremarkable blood counts/chemistry. Read More

Acta Derm Venereol 2018 Nov 14. Epub 2018 Nov 14.

Deparment of Dermatology, University of Oulu, FIN-90029 Oulu, Finland.

Br J Dermatol 2018 Nov 12. Epub 2018 Nov 12.

Department of Genetic Biochemistry, Robert-Debré Hospital, AP-HP and University of Paris-Diderot, Paris, France.

Background: Data on dermatological manifestations of Noonan syndrome (NS) remain heterogeneous and based on little dermatological expertise.

Objectives: To describe the dermatological manifestations of NS, compare them with the literature findings, and test for dermatological phenotype-genotype correlations with or without the presence of PTPN11 mutations.

Methods: We performed a large, 4-year, prospective, multicentric, collaborative dermatological and genetic study. Read More

JAAD Case Rep 2018 Nov 2;4(10):993-995. Epub 2018 Nov 2.

Department of Dermatology, Getulio Vargas University Hospital, Amazonas, Brazil.

Skinmed 2018 9;16(5):337-339. Epub 2018 Nov 9.

West Bengal Skineplex, Center of Dermatology, Burdwan, West Bengal, India.

A 56-year-old man presented with multiple, skin-colored, raised eruptions of the scrotum that had been present for 2 years. Their onset had been gradual, and they had been increasing in size, resulting in cosmetic disfigurement. A year previously, he had been operated on for a bilateral vaginal hydrocele with partial excision and eversion of the sac (Jabouley method). Read More

Skin Appendage Disord 2018 Oct 26;4(4):331-334. Epub 2018 Mar 26.

Department of Dermatology, University of California San Diego, La Jolla, California, USA.

Half-and-half nails were originally described as a transverse leukonychia in patients with chronic renal disease; other conditions (such as Behcet's and Crohn's disease) and medications (such as isoniazid) have also been associated with the nail changes. However, longitudinal half-and-half nails (affecting the medial aspects of the nails) have previously been reported on the great toes of an older woman and, in the present case, on the thumbs of an elderly man; neither person had Behcet's, Crohn's, or kidney disease or was receiving isoniazid. The woman had a true leukonychia, bilateral hallux valgus deformity, and chronic trauma to her medial nail folds. Read More

Skin Appendage Disord 2018 Oct 10;4(4):326-330. Epub 2018 Jan 10.

Department of Dermatology, Weill Cornell Medicine, New York, New York, USA.

Onychogryphosis is a disorder of nail plate growth that is clinically characterized by an opaque, yellow-brown thickening of the nail plate with associated gross hyperkeratosis, elongation, and increased curvature. It is most common in older adults and patients with poor personal care. It is a relatively common and important condition because patients may suffer from pain, secondary complications, and cosmetic concerns. Read More

J Biol Chem 2018 Nov 8. Epub 2018 Nov 8.

BBRI, North Carolina Central University, United States.

Mutations in the genes encoding nuclear factor (erythroid-derived 2)-like 2 (NRF2), Kelch-like ECH-associated protein 1 (KEAP1), and cullin 3 (CUL3) are commonly observed in human esophageal squamous cell carcinoma (ESCC) and result in activation of the NRF2 signaling pathway. Moreover, hyperactivity of the transcription factor Nrf2 has been found to cause esophageal hyperproliferation and hyperkeratosis in mice. However, the underlying mechanism is unclear. Read More

J Wound Care 2018 Nov;27(11):790-796

Centro Polivalente de Recursos para Personas Mayores El Cristo. Oviedo. Spain.

Objective:: Wound assessment is an essential part of wound management and has traditionally focused on the wound bed. The Triangle of Wound Assessment (Triangle) is a new assessment tool that includes a holistic evaluation of the patient with a wound. The aim of this pilot study was to describe the use of the Triangle in our clinical practice in Spain. Read More

Int J Clin Pediatr Dent 2018 Jul-Aug;11(4):352-355. Epub 2018 Aug 1.

Diplomate and Vice Dean, Division of Periodontics, Department of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan, Kingdom of Saudi Arabia.

Papillon-Lefèvre is an autosomal recessive syndrome that starts in early periods of childhood. Characteristic features include palmar plantar hyperkeratosis, aggressive periodontal disease, and a tendency for dry and chopped skin, thin and sparse hair. Patients show signs of premature tooth loss at the age of 2 to 4 years, which is then followed by the loss of permanent dentition during adolescence. Read More

Biochem Biophys Res Commun 2018 Dec 31;506(4):854-861. Epub 2018 Oct 31.

NRC Kurchatov Institute, Moscow, Russian Federation. Electronic address:

Exposure to toxic halogenated polyaromatic hydrocarbons, of which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most potent, induces diverse skin pathologies in humans, including chloracne, hyperkeratosis, hamartomas, etc. While the toxic effects of TCDD have been extensively studied, effective approaches to their treatment are still lacking. Retinoids are commonly used in therapy of acneiform skin diseases. Read More

Curr Pharm Des 2018 Nov 2. Epub 2018 Nov 2.

Department of Pharmaceutics; I.S.F. College of Pharmacy, Ghal Kalan, Ferozpur, G.T road, Moga- 146001, Punjab. India.

Background: Psoriasis is autoimmune disease of the skin with lapsing episodes of hyperkeratosis, irritation and inflammation. Numerous methodologies and by utilizing different antipsoriatic drugs with various methods of activity and routes of administration have been investigated to treat this terrifying sickness. In any case, till date there is no remedy for psoriasis because of absence of an ideal carrier for effective and safe delivery of antipsoriatic drugs. Read More

North Clin Istanb 2018 21;5(2):114-119. Epub 2018 May 21.

Department of Dermatology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.

Objective: Obesity is known to be a risk factor for many diseases including dermatological problems. Here, we aimed to determine the cutaneous manifestations in obese patients and the frequency of the accompanying dermatoses and to investigate the effect of diabetes mellitus in obese patients on cutaneous manifestations compared with the control group.

Methods: Our study included a total of 600 adults: 450 obese volunteers and 150 healthy volunteers. Read More

Cutis 2018 09;102(3):E19-E21

Heritage College of Osteopathic Medicine, Ohio University, Athens, USA.

F1000Res 2018 6;7:1420. Epub 2018 Sep 6.

Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Papillon-Lefèvre syndrome (PLS) is considered a rare syndrome, which is characterized by the presence of palmar-plantar hyperkeratosis and aggressively progressing periodontitis that finally leads to premature loss of both deciduous and permanent teeth. A four-year-old Egyptian boy presented with a maternal complaint that her child suffers from early loss of many teeth, presence of loose teeth along with an asymptomatic swelling related to the upper anterior area. The patient was diagnosed with PLS. Read More

Foot (Edinb) 2018 Sep 15;36:43-48. Epub 2018 Mar 15.

Department of Health and Management, National Institute for Physical Education of Catalonia (INEFC) - Lleida Centre, University of Lleida, Lleida, Spain.

Tactile information picked up by plantar receptors provides afferent sensory information that is fundamental for controlling body balance. Plantar hyperkeratoses may alter the quality and quantity of such information, thereby modifying balance.

Aim: Analyse how plantar hyperkeratosis debridement affects static body balance in subjects of 65 years of age or older. Read More

Eur J Pharm Sci 2018 Oct 11;127:1-8. Epub 2018 Oct 11.

National and Kapodistrian University of Athens, School of Health Sciences, Department of Pharmacy, Section of Pharmaceutical Technology, Panepistimiopolis Zografou, 15784 Athens, Greece. Electronic address:

Non-invasive biophysical methods were used to study the effect of antioxidant gels, which were prepared from Pinus halepensis bark extracts, vitamin C and water, on the skin of diabetic hairless mice irradiated with UV radiation of 1 and 2 minimal erythemal doses (MEDs). The calculated transepidermal water loss (TEWL) for diabetic mice was found to be fivefold higher on day 11 after irradiation, and in all cases, the TEWL values converged to their initial values on day 21. Both pinus and vitamin C gels inhibited the dehydration of the skin, while water gels did not show similar protection. Read More

Vet Clin North Am Food Anim Pract 2018 Nov;34(3):439-456

Cognosco-Anexa FVC, 25 Moorhouse Street, Morrinsville 3340, New Zealand. Electronic address:

Automatic milking systems, or robotic milking systems, are now well established as a milk harvesting technology in Europe, Nth America and Australasia. This system is quarter based harvesting where human activity is not routinely required for milking or initial mastitis detection activities. Mastitis risk factors common with conventional milking are: environmental contamination, teat congestion and teat hyperkeratosis risk. Read More

Exp Dermatol 2018 Oct 13. Epub 2018 Oct 13.

Department of Anatomy and Embryology, College of Medicine, Mansoura University, 35516, Egypt.

Although, there are many treatment options for skin cancer, the chemotherapeutic agents for skin cancer are linked with many adverse effects as well as development of multidrug resistance. Sulforaphane is an isothiocyanate, which is found in cruciferous vegetables. Consumption of sulforaphane rich diet has been linked to inhibition of UV-exposed skin carcinogenesis. Read More

Exp Mol Pathol 2018 Dec 9;105(3):322-327. Epub 2018 Oct 9.

Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1, Higashijima, Akiha ku, Niigata 956-8603, Japan; National Institute of Pharmaceutical Education and Research, Chuilal Bhawan, 168 Manicktala Main Road, Kolkata 700054, West Bengal, India. Electronic address:

Basidiomycetes-X (BDM-X) is a novel edible mushroom recently identified as a new fungi species and is effective against oxidative stress and anti-inflammation associated with immune response. However the effect of BDM-X on atopic dermatitis (AD) has not been elucidated. In this study, we have investigated the effect of BDM-X on AD skin lesions in NC/Nga mouse model. Read More

Am J Transplant 2018 Oct 12. Epub 2018 Oct 12.

Program in Dermatopathology, Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.

Face vascularized composite allografts (FVCAs) have helped patients with severe facial disfigurement, with acute rejection now largely controlled through iatrogenic immunosuppression. However, little is known regarding the incidence and mechanism(s) of more long-term pathologic alterations in FVCAs that may affect function and graft durability. Protocol surveillance biopsy specimens for up to an 8-year interval in 7 patients who received FVCAs at our institution revealed histopathologic evidence of chronic rejection. Read More

Br J Dermatol 2018 Oct 11. Epub 2018 Oct 11.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, U.S.A.

Pachyonychia congenita (PC) is a rare autosomal dominant disorder characterized by nail dystrophy and palmoplantar keratoderma with severe plantar pain affecting quality of life. There is no effective treatment. Heterozygous mutations in the keratin genes KRT6A, KRT6B, KRT6C, KRT16 and KRT17 have been reported as a cause of PC. Read More

J Dtsch Dermatol Ges 2018 Nov 8;16(11):1368-1370. Epub 2018 Oct 8.

Department of Dermatology, University Hospital Regensburg, Germany.

Mov Disord 2018 Oct 4;33(10):1665-1666. Epub 2018 Oct 4.

Institute of Human Genetics, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

J Eur Acad Dermatol Venereol 2018 Oct 4. Epub 2018 Oct 4.

Department of Dermatology and Venereology, Third Military Medical University, Chongqing, China.

First reported from Taiwan mistakenly as acral acanthosis nigricans in 1991, pigmented carpotarsal hyperkeratosis or hyperkeratosis nigricans carpi et tarsi displays a peculiar distribution of velvety brown-grey hyperpigmented plaques symmetrically on the flexural side of the wrists and ankles and on the dorsal sides of the hands and feet. A marked epidermal hyperkeratosis with typically mild acanthosis and papillomatosis is observed in histology. Whitish maceration upon perspiration or water exposure, with exacerbation in summer but remission in winter, is common. Read More

Biomed Res Int 2018 9;2018:8251097. Epub 2018 Sep 9.

Department of Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-900 Olsztyn, Poland.

Aim Of The Study: The aim of the study was to conduct an ultrasound (US) assessment of changes in fingernails in psoriatic patients with nail involvement.

Material: A total of 69 patients with psoriatic changes in nails participated in the study, including 38 patients with psoriasis (Ps) and 31 with psoriatic arthritis (PsA) and 30 people in the control group. A total of 988 nails were examined. Read More

Ann Agric Environ Med 2018 Sep 9;25(3):421-427. Epub 2018 Apr 9.

1st Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University, Prague, Czech Republic.

Introduction And Objective: Polychlorinated biphenyls (PCBs) have been used commercially since 1929 as dielectric and insulating non-flammable substances, additives for paints, etc. In Slovakia, 60 chemical production workers highly exposed to PCBs (mainly to Delor 103) were studied with duration of exposure ranging from 3 months to 19 years.

Material And Methods: Clinical examinations of skin, skin histology and laboratory tests concerning lipid metabolism, iron metabolism and levels of copper provided comparisons with a control group of healthy individuals and/or the upper limits of normal values. Read More

Indian Dermatol Online J 2018 Sep-Oct;9(5):334-337

Department of Pathology, JSS Medical College and Hospital, JSS University, Mysuru, Karnataka, India.

Locus minoris resistentiae (LMR) is a site of the body that offers lesser resistance than the rest of the body to the onset of disease. It can be congenital or acquired. Areas of cutaneous mosaicism such as epidermal nevi can act as congenital LMR, leading to the development of inflammatory skin conditions or skin tumors on these. Read More

Indian Dermatol Online J 2018 Sep-Oct;9(5):314-317

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Nail involvement in psoriasis is often complicated by concomitant fungal infections. The aim of this study was to investigate the prevalence of fungal infections in nail psoriasis and correlate it with the severity of nail psoriasis.

Materials And Methods: This retrospective study included patients with nail psoriasis aged ≥18 years with at least one fingernail and one toenail involvement who were treated at Siriraj Hospital from September 2012 to January 2014. Read More

Int J Vet Sci Med 2017 Dec 9;5(2):152-158. Epub 2017 Nov 9.

Department of Public Health, Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Nairobi, Kenya.

The objective of this study was to evaluate the gross and histo-pathological lesions caused by plastic bags in the rumen of sheep. Sixteen (16) castrated, one-year old Dorper sheep were used for the study. The animals were divided into 4 groups each consisting of 4 sheep. Read More

Vet Parasitol 2018 Sep 5;261:96-103. Epub 2018 Sep 5.

Universidade Federal de São João del-Rei (UFSJ), Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil. Electronic address:

Canine visceral leishmaniosis (CVL), a parasitic disease caused by Leishmania infantum, may evolve to a chronic condition and lead to death. Evaluation of infected dogs is important to establish the clinical and laboratory parameters involved in the evolution of the disease. The objectives of the present study were to discriminate a canine population (n = 52) into sub-clinical and clinically affected dogs based on signs and scores, to evaluate the hematological, biochemical, histopathological and parasitological parameters of the two dog groups, and to analyze the results by multivariate regression analysis with the aim of establishing biomarkers of CVL clinical disease. Read More

Am J Dermatopathol 2018 Aug 15. Epub 2018 Aug 15.

Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

An 8-year-old girl presented with a persistent 5 × 2-cm violaceous doughy plaque on the left lower leg. Histologic examination revealed hyperkeratosis, variable but mild epidermal hyperplasia, and vacuolar interface changes with melanin pigment incontinence confined to the papillary dermis. A diagnosis of pretibial lymphoplasmacytic plaque in children was made. Read More

Laryngoscope 2018 Sep 19. Epub 2018 Sep 19.

Department of Endoscopy, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objectives: The purpose of this study was to introduce a new narrow band imaging (NBI) endoscopic classification for the diagnosis of vocal cord leukoplakia.

Study Design: Case series.

Methods: From January 2010 to February 2018, a total of 120 cases of vocal cord leukoplakia were enrolled in this study. Read More

Am J Gastroenterol 2018 Nov 13;113(11):1733-1734. Epub 2018 Sep 13.

Gastroenterology Department, Carl T Hayden VA Medical Center, Phoenix, AZ, USA.

J Int Med Res 2018 Nov 13;46(11):4722-4730. Epub 2018 Sep 13.

2 Hard Tissue Pathology Unit, Graduate School of Oral Medicine, Matsumoto Dental University, Nagano, Japan.

Objective: Oral lichen planus (OLP) characterized by interface mucositis frequently shows hyper-keratinization. To clarify mechanisms of excess keratinization, we investigated key molecules for cornified cell envelope (CE).

Methods: Involucrin (IVL), loricrin (LOR), transglutaminase 1 (TGase 1) and transglutaminase 3 (TGase 3) were immunohistochemically examined in 20 specimens of OLP; five specimens of buccal mucosa served as controls. Read More