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Crit Care Nurs Q 2019 Jan/Mar;42(1):44-46

Emergency Department, Bellevue Hospital Center, NYU School of Medicine, New York (Mr Malek); and Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, and NYU Rory Meyers College of Nursing, New York (Dr Chen).

Physiological derangements such as hypoxemia and hyperkalemia are medical emergencies that warrant prompt interventions to prevent further patient clinical deterioration. However, in patients with myeloproliferative diseases or malignancies that result in extreme leukocytosis, hypoxemia and hyperkalemia demonstrated in laboratory results could be deceiving due to in vitro reactions and may not reflect actual patient condition. Clinicians have to be familiar with these phenomena so as to not cause harm by treating these spurious laboratory values. Read More

Crit Care Nurs Q 2019 Jan/Mar;42(1):30-40

Department of Baccalaureate Nursing, Indiana State University, Monroeville (Mr Blauvelt); and School of Nursing, Indiana State University, Terre Haute (Drs Burdick and Cannon).

The use of neuromuscular blocking agents (NMBAs) in acute care settings during intubation is vitally important. The NMBAs increase first pass success rates significantly while protecting patients from gastric aspiration, tracheal injury, and death. During emergent intubations, succinylcholine and rocuronium are commonly used, but each comes with specific risks and individualized interventions. Read More

Expert Rev Clin Pharmacol 2018 Dec 2. Epub 2018 Dec 2.

a Department of Neurology and Psychiatry , Assiut University Hospital , Assiut , Egypt.

Introduction: Uremic syndrome of chronic kidney disease (CKD) is a term used to describe clinical, metabolic and hormonal abnormalities associated with progressive kidney failure. It is a rapidly growing public health problem worldwide. Nervous system complications occur in every patient with uremic syndrome of CKD. Read More

J Clin Med 2018 Dec 1;7(12). Epub 2018 Dec 1.

Division of Nephrology, Department of Advanced Medical and Surgical Sciences, Nephrology Unit-University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

Hyperkalaemia burden in non-dialysis chronic kidney disease (CKD) under nephrology care is undefined. We prospectively followed 2443 patients with two visits (referral and control with 12-month interval) in 46 nephrology clinics. Patients were stratified in four categories of hyperkalaemia (serum potassium, sK ≥ 5. Read More

South Med J 2018 Dec;111(12):754-757

From the Hospital Medicine Unit and the Core Educator Faculty and Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, the Heart and Vascular Center, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

We present the case of a 47-year-old man with a history of diabetes mellitus and diabetic nephropathy who was admitted to our hospital with acute uremic myopericarditis. Echocardiography demonstrated a fibrinous pericardial effusion. The patient was initiated on hemodialysis for hyperkalemia, metabolic acidosis, and uremia. Read More

Arch Pathol Lab Med 2018 Nov 30. Epub 2018 Nov 30.

From the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis.

Tumor lysis syndrome (TLS) is an acute, life-threatening disease among adults and children that is associated with the initiation of cytoreductive therapy in the treatment of malignancy. A pattern of metabolic derangements occurs as a result of a massive release of intracellular contents into the systemic circulation. Characteristic findings include hyperuricemia, hyperphosphatemia, hyperkalemia, hypocalcemia, and uremia, all of which can lead to cardiac arrhythmia, seizures, renal failure, and sudden death. Read More

Clin J Am Soc Nephrol 2018 Nov 29. Epub 2018 Nov 29.

Division of Nephrology, Department of Medicine, University of California, San Diego, California; and

Mymensingh Med J 2018 Oct;27(4):723-729

Dr Mrinal Kanti Das, Assistant Registrar, Department of Paediatrics, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh.

Complication of perinatal asphyxia is a major cause of neonatal mortality & morbidity in developing countries. This comparative cross sectional study was conducted in Mymensingh Medical College Hospital, Mymensingh, Bangladesh from May 2012 to September 2012 to determine electrolytes & renal function status in perinatal asphyxia & their impact on outcome. Thirty term normal birth weight babies with perinatal asphyxia in neonatal ward were included as a case group and thirty term normal birth weight neonates of same gestational age, without perinatal asphyxia in the department of Gynae & Obs were enrolled as a control group. Read More

Acta Clin Belg 2018 Nov 27:1-5. Epub 2018 Nov 27.

c Antwerp University Hospital and University of Antwerp , Edegem.

Objectives: Water and electrolytes disturbances often occur in renal transplant recipients. The objective is to describe the pathophysiology and the treatment of the most prevalent abnormalities.

Methods: We screened PubMed for the following words in various combination: kidney transplantation and (disturbances or abnormalities) of (electrolytes or sodium or potassium or phosphate or calcium or acid-base). Read More

Endocrinol Diabetes Metab Case Rep 2018 Nov 22;2018. Epub 2018 Nov 22.

Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

Addison's disease (AD) is the most common endocrine manifestation of antiphospholipid syndrome (APS), but it remains a very rare complication of the syndrome. It is caused by adrenal venous thrombosis and consequent hemorrhagic infarction or by spontaneous (without thrombosis) adrenal hemorrhage, usually occurring after surgery or anticoagulant therapy. We present a clinical case of a 36-year-old female patient with a previous diagnosis of APS. Read More

Rev Clin Esp 2018 Nov 22. Epub 2018 Nov 22.

Servicio de Urgencias, Unidad de Corta Estancia y Unidad de Hospitalización a Domicilio, Hospital Universitario General de Alicante, Alicante, España.

Kidney Int 2018 Nov 22. Epub 2018 Nov 22.

Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Renal, Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

The safety and efficacy of spironolactone is uncertain in end-stage renal disease. We randomized 129 maintenance hemodialysis patients to placebo (n=51) or spironolactone 12.5 mg (n=27), 25 mg (n=26), or 50 mg (n=25) daily for 36 weeks in a double-blind, placebo-controlled, multiple dosage trial to assess safety, tolerability and feasibility and to explore cardiovascular efficacy. Read More

Nephrol Ther 2018 Nov;14(6S):6S17-6S25

Service de néphrologie, hôpital Necker-Enfants malades, 149, rue de Sèvres 75015 Paris, France. Electronic address:

Metabolic complications of chronic kidney disease (CKD) are frequent; the aims of this review are to present a 2018 update for hyperkalemia, hyperphosphatemia and anemia. Hyperkalemia is defined by a plasma level above 5.0 mmol/L, after ruling out pre-analytical problems such as hemolysis. Read More

J Clin Med 2018 Nov 21;7(11). Epub 2018 Nov 21.

Department of Internal Medicine, Changhua Christian Hospital, Changhua 50006, Taiwan.

Background: Spironolactone, a non-selective mineralocorticoid receptor antagonist, can protect against cardiac fibrosis and left ventricular dysfunction, and improve endothelial dysfunction and proteinuria. However, the safety and effects of spironolactone on patient-centered cardiovascular and renal endpoints remain unclear.

Methods: We identified predialysis stage 3⁻4 chronic kidney disease (CKD) patients between 2000 and 2013 from the Longitudinal Health Insurance Database 2005 (LHID 2005). Read More

J Med Syst 2018 Nov 22;43(1). Epub 2018 Nov 22.

Department of Anesthesiology, NorthShore University HealthSystem, University of Chicago Pritzker School of Medicine, 2650 Ridge Ave, Evanston, IL, 60201, USA.

The aim of this study was to assess the effect of a dynamic electronic cognitive aid with embedded clinical decision support (dCA) versus a static cognitive aid (sCA) tool. Anesthesia residents in clinical anesthesia years 2 and 3 were recruited to participate. Each subject was randomized to one of two groups and performed an identical simulated clinical scenario. Read More

Pediatr Clin North Am 2019 Feb;66(1):135-157

Division of Nephrology, Department of Pediatrics, The Montreal Children's Hospital, McGill University Health Centre, Room B RC.6651, Montreal, Quebec H4A 3J1, Canada; Al Jalila Children's Hospital, Al Jadaf PO Box 7662, Dubai, UAE. Electronic address:

Renal tubular acidosis should be suspected in poorly thriving young children with hyperchloremic and hypokalemic normal anion gap metabolic acidosis, with/without syndromic features. Further workup is needed to determine the type of renal tubular acidosis and the presumed etiopathogenesis, which informs treatment choices and prognosis. The risk of nephrolithiasis and calcinosis is linked to the presence (proximal renal tubular acidosis, negligible stone risk) or absence (distal renal tubular acidosis, high stone risk) of urine citrate excretion. Read More

Clin Trials 2018 Nov 16:1740774518813121. Epub 2018 Nov 16.

1 Cooperative Studies Program Coordinating Center (CSPCC), VA Connecticut Healthcare System, West Haven, CT, USA.

Background/aims:: Electronic medical records are now frequently used for capturing patient-level data in clinical trials. Within the Veterans Affairs health care system, electronic medical record data have been widely used in clinical trials to assess eligibility, facilitate referrals for recruitment, and conduct follow-up and safety monitoring. Despite the potential for increased efficiency in using electronic medical records to capture safety data via a centralized algorithm, it is important to evaluate the integrity and accuracy of electronic medical record-captured data. Read More

Curr Clin Pharmacol 2018 Nov 15. Epub 2018 Nov 15.

Department of Clinical Pharmacology, SRM MCH &RC, Kattankulathur, Chennai, Tamil Nadu. India.

Diabetic nephropathy (DN) is defined as a decline in the renal function and an increase in the amount of albuminuria (>300 mg/day). The well-established first-line drug therapies for DN include angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) and the second line drug therapies include calcium channel blockers or diuretics. The interruption of the renin-angiotensin-aldosterone system (RAAS) by ACEi and ARBs has been beneficial in reducing the progression of renal diseases; however, there is an increase in the levels of aldosterone due to the aldosterone escape phenomenon. Read More

Shock 2018 Dec;50(6):677-683

Clinical Investigation Facility, David Grant USAF Medical Center, Travis Air Force Base, California.

Introduction: The standard of care for refractory hyperkalemia is renal replacement therapy (RRT). However, traditional RRT requires specialized equipment, trained personnel, and large amounts of dialysate. It is therefore poorly suited for austere environments. Read More

Open Vet J 2018 12;8(4):351-359. Epub 2018 Oct 12.

Animal Health Research Institute, Assuit, Egypt.

The present study was carried out to characterize pathogenic in apparently healthy and diarrheic neonatal calves with special reference to the hybrid strains and evaluate their clinical and hematobiochemical consequences. One hundred and seventy calves (age 1-30 days) were divided into two groups: apparently healthy (n = 70) and diarrheic (n=100). Animals were subjected to thorough clinical, hematobiochemical and bacteriological examinations. Read More

Curr Heart Fail Rep 2018 Dec;15(6):390-397

Department for Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, Saarland University Medical Center, Kirrberger Strasse, 66421, Homburg, Saarland, Germany.

Purpose Of Review: Hyperkalaemia is a frequent and sometimes life-threatening condition that may be associated with arrhythmia and cardiac dysfunction. Evaluating the prevalence of hyperkalaemia in patients with heart failure (HF) and potential treatments of this condition is essential for patients using renin-angiotensin-aldosterone system inhibitors or angiotensin receptor-neprilysin inhibitor and mineralocorticoid receptor antagonists, which represent the cornerstone and highly proven life-saving therapy.

Recent Findings: Novel findings from the past few years include data regarding the epidemiology, pathomechanisms, implications and novel therapeutic approaches to counteract hyperkalaemia in patients with HF. Read More

Anesth Analg 2018 Nov 9. Epub 2018 Nov 9.

From the Department of Anesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany.

Background: Targeted temperature management is a standard therapy for unconscious survivors of cardiac arrest. To date, multiple cooling methods are available including invasive intravascular cooling devices (IVDs), which are widely used in the clinical setting. Recently, esophageal heat exchangers (EHEs) have been developed providing cooling via the esophagus that is located close to the aorta and inferior vena cava. Read More

J Nutr Metab 2018 17;2018:5989307. Epub 2018 Oct 17.

Department of Biological, Environmental & Occupational Health Sciences, School of Public Health, College of Health Sciences, University of Ghana, Accra, Ghana.

The World Health Organization (WHO) has highlighted the beneficial role of adequate intake of potassium (K) in combating the global burden of noncommunicable diseases (NCDs), mainly hypertension and cardiovascular diseases. Diets are the main source of K supply to humans and can contribute to both K deficiency (hypokalemia) and excess (hyperkalemia). While global attention is currently devoted to K deficiency, K excess can be even more dangerous and deserves equal attention. Read More

J Emerg Nurs 2018 Nov;44(6):549

N Engl J Med 2018 Nov 11. Epub 2018 Nov 11.

From the Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (E.J.V.); the Thrombolysis in Myocardial Infarction Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston (D.A.M., E.B.); Duke Clinical Research Institute, Duke University, Durham, NC (A.D.D.); Novartis Pharmaceuticals, East Hanover, NJ (C.I.D., K.M., R.R.); and the Division of Cardiology, Permanente Medical Group, San Francisco, and the Division of Research, Kaiser Permanente Northern California, Oakland - both in California (A.P.A.).

Background: Acute decompensated heart failure accounts for more than 1 million hospitalizations in the United States annually. Whether the initiation of sacubitril-valsartan therapy is safe and effective among patients who are hospitalized for acute decompensated heart failure is unknown.

Methods: We enrolled patients with heart failure with reduced ejection fraction who were hospitalized for acute decompensated heart failure at 129 sites in the United States. Read More

Expert Rev Proteomics 2018 Nov 9:1-16. Epub 2018 Nov 9.

b Nephrology , IIS-Fundacion Jimenez Diaz and Universidad Autonoma de Madrid , Madrid , Spain.

Introduction: Renin-angiotensin system (RAS) blockers are in clinical use to treat high blood pressure and proteinuric chronic kidney disease. However, RAS blockade is limited by the risk of hyperkalemia, angiotensin receptor blockers are not clinically superior to angiotensin-converting enzyme inhibitors and dual RAS blockade is formally contraindicated. Areas covered: We review the regulation of protein expression and activation by angiotensin II and RAS blockers as it contributes to kidney disease. Read More

Avian Pathol 2018 Nov 9:1-49. Epub 2018 Nov 9.

b School of Animal & Veterinary Sciences , University of Adelaide , Roseworthy Campus, SA 5371 Australia.

The pathophysiology of heat illnesses in birds has not been well characterised. In this study, we describe the changes in heart rate, respiratory rate, blood biochemistry and histopathological findings in galahs and rock doves after heat exposure under standardized conditions designed to induce heatstroke. Birds in the heat exposed group were exposed to environmental heat stress and compared to control birds. Read More

Am J Transplant 2018 Nov 9. Epub 2018 Nov 9.

Section of HPB Surgery and Liver Transplantation, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Liver transplantation is frequently associated with hyperkalemia, especially after graft reperfusion. Dual hypothermic oxygenated machine perfusion (DHOPE) reduces ischemia/reperfusion injury and improves graft function, compared to conventional static cold storage (SCS). We examined the effect of DHOPE on ex situ and in vivo shifts of potassium and sodium. Read More

Case Rep Cardiol 2018 15;2018:7686373. Epub 2018 Oct 15.

San Diego Internal Medicine and Pediatrics Associates, San Diego, CA, USA.

This report describes the occurrence of asymptomatic hyperkalemia induced by the sequential administration of metoprolol and carvedilol in an 81-year-old man with type II diabetes and stable stage III renal insufficiency. The potassium level rose to 5.6-5. Read More

Drugs Today (Barc) 2018 Oct;54(10):601-613

Hospital Clínico de Valencia, Universitat de Valencia, INCLIVA, Valencia, Spain.

Hyperkalemia is one of the most common electrolyte disturbances, especially among some groups of patients, such as in those with chronic kidney disease, diabetes or heart failure. Hyperkalemia has been associated with increased risks of mortality, arrhythmias, hospitalization and costs, as well as the need to down titrate/discontinue renin-angiotensin-aldosterone system inhibitors (RAASIs), despite their well-known cardiovascular and nephroprotective benefits. Current potassium binders have limitations (slow onset of action, limited selectivity for potassium binding, risk of drug interactions or gastrointestinal intolerance). Read More

J Emerg Med 2018 Oct 31. Epub 2018 Oct 31.

Saint Luke's Mid America Heart Institute and University of Missouri-Kansas City, Kansas City, Missouri.

Background: Contemporary emergency department (ED) standard-of-care treatment of hyperkalemia is poorly described.

Objective: Our aim was to determine the treatment patterns of hyperkalemia management in the ED.

Methods: This multicenter, prospective, observational study evaluated patients aged ≥ 18 years with hyperkalemia (potassium [K] level ≥ 5. Read More

J Small Anim Pract 2018 Nov 3. Epub 2018 Nov 3.

Department of Internal Medicine, Ecole nationale vétérinaire d'Alfort, Paris, F-94700, France.

A 7-year-old mixed breed dog was presented with a 2-week history of vomiting, diarrhoea, weakness and loss of appetite. Initial laboratory tests revealed hyponatraemia and hyperkalaemia consistent with hypoadrenocorticism. Basal plasma cortisol and adrenocorticotropic hormone concentrations were not suggestive of primary hypoadrenocorticism but the aldosterone concentration was undetectable. Read More

Kidney Int 2018 Oct 31. Epub 2018 Oct 31.

Bristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.

Aldosterone contributes to end-organ damage in heart failure and chronic kidney disease. Mineralocorticoid-receptor inhibitors limit activation of the receptor by aldosterone and slow disease progression, but side effects, including hyperkalemia, limit their clinical use. Damage to the endothelial glycocalyx (a luminal biopolymer layer) has been implicated in the pathogenesis of endothelial dysfunction and albuminuria, but to date no one has investigated whether the glomerular endothelial glycocalyx is affected by aldosterone. Read More

Nurs Clin North Am 2018 Dec 11;53(4):469-480. Epub 2018 Oct 11.

Austin Peay State University, School of Nursing, 601 College Street, Clarksville, TN 37043, USA.

The frontline nurse is confronted daily with patients that have some type of kidney dysfunction or disease. Some renal issues resolve themselves, some disorders can be reversed, and others are permanent. Major complications from kidney impairment discussed are fluid and electrolyte disequilibrium with common problems in volume overload, hyperkalemia, metabolic acidosis, hyperphosphatemia, and hormonal secretion. Read More

Pediatr Nephrol 2018 Oct 31. Epub 2018 Oct 31.

Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, RJ, India.

Pediatr Nephrol 2018 Oct 31. Epub 2018 Oct 31.

Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, RJ, India.

Clin J Am Soc Nephrol 2018 Oct 31. Epub 2018 Oct 31.

Renal Associates, PA, San Antonio, Texas.

Background And Objectives: Patiromer is a sodium-free, nonabsorbed, potassium-binding polymer that uses calcium as the counter-exchange ion and is approved for treatment of hyperkalemia. The 4-week TOURMALINE study in patients with hyperkalemia previously demonstrated that patiromer administered once daily reduces serum potassium similarly when given with or without food. We report a prespecified exploratory efficacy analysis as well as a efficacy and safety analysis of the TOURMALINE study on circulating markers of mineral metabolism. Read More

Clin Chem 2018 Nov;64(11):1673

Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

Trials 2018 Oct 30;19(1):595. Epub 2018 Oct 30.

INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, France.

Background: Despite advances in immunosuppressive therapy, kidney graft survival has failed to improve during the last decades. Ischemia/reperfusion injury (IRI) is one of the main pathophysiological mechanisms underlying delayed graft function, which is associated with poor long-term graft survival. Due to organ shortage, the proportion of grafts from expanded criteria donors (ECDs) is ever growing. Read More

Pol Merkur Lekarski 2018 Oct;45(268):158-160

Warmińsko-Mazurski University of Olsztyn: Department of Nephrology, Hypertensiology and Internal Diseases.

Heparins are drugs commonly used in the prevention and treatment of thromboembolic complications. It is also common to be aware of the complications of their use, such as increased risk of bleeding or induction of throbocytopenia. However, it should not be forgotten that in about 7% of patients the use of heparins may lead to the significant hyperkalaemia. Read More

Cardiorenal Med 2018 Oct 25;9(1):8-21. Epub 2018 Oct 25.

Department of Nephrology and Dialysis, ASTT Lariana, S. Anna Hospital, Como, Italy.

Chronic hyperkalemia (HK) is a serious medical condition that often manifests in patients with chronic kidney disease (CKD) and heart failure (HF) leading to poor outcomes and necessitating careful management by cardionephrologists. CKD, HF, diabetes, and renin-angiotensin-aldosterone system inhibitors use is known to induce HK. Current therapeutic options are not optimal, as pointed out by a large number of CKD and HF patients with HK. Read More

J Community Hosp Intern Med Perspect 2018 15;8(5):307-310. Epub 2018 Oct 15.

Department of Medicine, MedStar Good Samaritan Hospital, Baltimore, MD, USA.

Synthetic cathinones represent the latest genre of new drugs of abuse, which are increasing in popularity in part because they are readily available and because they are not detected by routine drug testing. They provide a cheaper substitute to stimulants such as methamphetamine and cocaine and are sold on the internet and in retail establishments as 'bath salts,' 'plant food,' or 'research chemicals.' We report a case involving a 21-year-old male who suffered arrest-related death due to intoxication with -ethylpentylone, a new cathinone derivative. Read More

Front Immunol 2018 9;9:2320. Epub 2018 Oct 9.

Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Japan.

enterotoxin (CPE) is a common cause of food poisoning and hyperkalemia-associated death. Previously, we reported that fusion of pneumococcal surface protein A (PspA) to C-terminal fragment of CPE (C-CPE) efficiently bound mucosal epithelium so that PspA-specific immune responses could be provoked. In this study, we found that fusion of C-CPE with PspA augmented the antigenicity of C-CPE itself. Read More

Circ Heart Fail 2018 Aug;11(8):e004886

Columbia University, New York, NY (W.K.).

Background In patients with heart failure (HF), malnutrition and dietary sodium excess are common and may worsen outcomes. No prior studies have provided low-sodium, nutritionally complete meals following HF hospitalization. Methods and Results The GOURMET-HF study (Geriatric Out-of-Hospital Randomized Meal Trial in Heart Failure) randomized patients discharged from HF hospitalization to 4 weeks of home-delivered sodium-restricted Dietary Approaches to Stop Hypertension meals (DASH/SRD; 1500 mg sodium/d) versus usual care. Read More

Acta Clin Belg 2018 Oct 24:1-14. Epub 2018 Oct 24.

a Nephrology Section, Department of Internal Medicine , University Hospital Ghent , Belgium.

Objectives: In this publication, we review the definitions, symptoms, causes, differential diagnoses and therapies of hypokalemia and hyperkalemia.

Methods: Comprehensive tables and diagnostic algorithms are provided when appropriate.

Results And Conclusions: Although both hypokalemia and hyperkalemia may be life-threatening, this is essentially the case with severe changes (serum potassium < 2. Read More

Am J Emerg Med 2018 Oct 16. Epub 2018 Oct 16.

MiHAR lab, Université de Nantes, 44000 Nantes, France; Department of Emergency Medicine, CHU Nantes, Nantes, France.

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Oct;50(5):915-920

Department of Pharmacy, Peking University Third Hospital, Beijing 100191, China.

Pharmacokinetic parameters can be significantly altered for acute kidney injury (AKI), extracorporeal membrane oxygenation (ECMO) and continuous veno-venous hemofiltration therapy (CVVH). Here we reported a case of individualized vancomycin dosing for a patient diagnosed as severe acute pancreatitis treated with concurrent ECMO and CVVH. A 65 kg 32-year-old woman was admitted to hospital presented with severe acute pancreatitis (SAP), respiratory failure, metabotropic acidosis and hyperkalemia. Read More

Front Med (Lausanne) 2018 2;5:261. Epub 2018 Oct 2.

Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.

Kidney transplantation is the current treatment of choice for patients with end-stage renal disease. Innovations in transplantation and immunosuppression regimens have greatly improved the renal allograft survival. Based on recently published data from the Scientific Registry of Transplant recipients, prevalence of kidney transplants is steadily rising in the United States. Read More

Resuscitation 2018 Dec 12;133:137-140. Epub 2018 Oct 12.

Department of Intensive Care Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.

Introduction: Identifying reversible causes of cardiac arrest is challenging. The diagnosis of pulmonary embolism is often missed. Pulmonary embolism increases alveolar dead space resulting in low end-tidal CO (EtCO) relative to arterial CO (PaCO) tension. Read More

Expert Rev Anti Infect Ther 2018 Nov 23;16(11):793-803. Epub 2018 Oct 23.

c Department of Medicine , Duke University Medical Center , Durham , NC , USA.

Introduction: Iclaprim is a selective bacterial dihydrofolate reductase (DHFR) inhibitor. Although there are alternative options for the treatment of acute bacterial skin and skin structure infections (ABSSSI), iclaprim is differentiated from other available antibiotics. Areas covered: Iclaprim is under clinical development for ABSSSI. Read More