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    1 OF 88

    Is compensatory hyperhidrosis after thoracic sympathicotomy in palmar hyperhidrosis patients related to the excitability of thoracic sympathetic ganglions?
    J Thorac Dis 2017 Sep;9(9):3069-3075
    Department of Thoracic Surgery, Xiamen Hospital of Traditional Chinese Medicine, Xiamen 361000, China.
    Background: The mechanism of compensatory hyperhidrosis remains unclear. The aim of this study was to explore the relationship between compensatory hyperhidrosis and thoracic sympathetic ganglion excitability to assess the effectiveness of thoracoscopic T4 sympathicotomy for treating palmar hyperhidrosis.

    Methods: Sixty-six cases of T4 sympathetic ganglions were prospectively collected from patients with palmar hyperhidrosis who underwent thoracoscopic T4 sympathicotomy from 2013 to 2016 in our department. Read More

    Survival study of treatment adherence by patients given oral oxibutynin for hyperhidrosis.
    J Eur Acad Dermatol Venereol 2017 Dec 8. Epub 2017 Dec 8.
    Dermatology Department, Hospital Costa del Sol, Marbella, Málaga.
    Introduction: In recent years, increasing use has been made of oral anticholinergics such as oxybutynin for the management of hyperhidrosis. The primary aim of this study is to determine the variables associated with adherence to this treatment, and secondarily to obtain data on its effectiveness, safety and adverse effects.

    Material And Methods: Prospective study of patients with hyperhidrosis, at any location, receiving treatment with oral oxybutynin in the period 2007-2016. Read More

    Polyarthritis is a Rare Manifestation of Pachydermoperiostosis: A Case Report.
    Mymensingh Med J 2017 Oct;26(4):939-943
    Dr Md Faysal Ahmmed, Resident, Department of Rheumatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
    Pachydermoperiostosis or primary hypertrophic osteoarthropathy, also known as Touraine-Solente-Gole syndrome, is a rare process, frequently inherited. In its complete form it is characterized by pachydermia (thickening of the skin), skeletal changes (periostosis) and acropachia (digital clubbing). Diagnosis can be made considering the typical clinical features and the histological feature. Read More

    Pulsed radiofrequency stimulation suppresses palmar hyperhidrosis in an animal study.
    Brain Behav 2017 Nov 26;7(11):e00833. Epub 2017 Sep 26.
    Department of Veterinary MedicineSchool of Veterinary MedicineNational Taiwan UniversityTaipeiTaiwan.
    Objectives: Palmar hyperhidrosis (PH) exhibits excessive and unpredictable sweating. The most effective treatment for permanent cure is the ablation of thoracic sympathetic ganglia innervating hands. However, sympathectomy of T2 sympathetic ganglion by clipping or cauterization causes irreversible nerve damage, and results in a compensatory hyperhidrosis (CH). Read More

    Treatment of Palmar Hyperhidrosis with Tap Water Iontophoresis: A Randomized, Sham-Controlled, Single-Blind, and Parallel-Designed Clinical Trial.
    Ann Dermatol 2017 Dec 30;29(6):728-734. Epub 2017 Oct 30.
    Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, Korea.
    Background: Palmar hyperhidrosis is a common disorder of excessive sweating. A number of studies have demonstrated the effectiveness of iontophoresis in the treatment of palmar hyperhidrosis. However, controlled clinical studies on iontophoresis for palmar hyperhidrosis have been limited. Read More

    [Aripiprazole-Induced Hyperhidrosis: Two Case Reports].
    Turk Psikiyatri Derg 2017 ;28(2):132-134
    Many drugs including anti-depressants and anti-psychotics are known to cause excessive sweating (hyperhidrosis). Hyperhidrosis may be caused by drugs acting at the hypothalamus, spinal thermoregulatory centres, and sympathetic ganglia or at the eccrine-neuroeffector junction. Hyperhidrosis can be distressing and embarrassing symptom, which if not addressed properly, may lead to non-concordance to medication. Read More

    Dermatologic manifestations of endocrine disorders.
    Transl Pediatr 2017 Oct;6(4):300-312
    The Ohio State University College of Medicine, Columbus, OH, USA.
    The skin serves as a window for clinicians to understand, diagnose, and monitor endocrine disease. Dermatologic manifestations of endocrinopathies contribute significantly to an individual's health and quality of life. In this review, we outline various disorders of the hypothalamic-pituitary axis, thyroid gland, pancreas, adrenal gland, and androgen axis as well as hereditary endocrine syndromes. Read More

    Phase IIIb safety results from an expanded-access protocol of talimogene laherparepvec for patients with unresected, stage IIIB-IVM1c melanoma.
    Melanoma Res 2017 Nov 22. Epub 2017 Nov 22.
    Department of Hematology and Oncology, Minnesota Oncology, Fridley, Minnesota.
    Talimogene laherparepvec is a genetically modified herpes simplex virus-1-based oncolytic immunotherapy for the local treatment of unresectable cutaneous, subcutaneous, and nodal tumors in patients with melanoma recurrence following surgery. We aim to describe the safety of talimogene laherparepvec. Intralesional talimogene laherparepvec was administered at less than or equal to 4 ml×10 PFU/ml at protocol day 1, then less than or equal to 4 ml×10 PFU/ml 21 days later, and then every 14 days. Read More

    [Palmar and axillary hyperhidrosis in children: endoscopic thoracic sympathectomy using clips for an underestimated problem].
    Ned Tijdschr Geneeskd 2017 ;161(0):D1615
    Albert Schweitzer ziekenhuis, Dordrecht.
    Background: Palmar and axillary hyperhidrosis are defined as perspiration exceeding the body's 'normal' physiological need for thermal regulation. This condition affects about 1% of adolescents and children and may lead to psychosocial problems and poor school performance.

    Case Description: We carried out an endoscopic thoracic sympathectomy (ETS) with clips in a 14-year-old girl and a 16-year-old girl who suffered from debilitating palmar and axillary hyperhidrosis. Read More

    Retroperitoneoscopic lumbar sympathectomy for plantar hyperhidrosis.
    J Vasc Surg 2017 Dec;66(6):1806-1813
    Department of Medicine, Universidade Tiradentes, Aracaju, Sergipe, Brazil.
    Objective: The objective of this study was to assess the reduction in quality of life (QoL) caused by the persistence of primary plantar hyperhidrosis (PPH) symptoms and the level of satisfaction in PPH patients after retroperitoneoscopic lumbar sympathectomy (RLS). The efficacy, safety, and procedure of bilateral RLS in both sexes are also described in this study.

    Methods: This is a longitudinal study of consecutive patients who sought specific treatment from a private practitioner for severe PPH as classified on the Hyperhidrosis Disease Severity Scale (HDSS) from October 2005 to October 2014. Read More

    Epidemiologic analysis of prevalence of the hyperhidrosis.
    An Bras Dermatol 2017 Sep-Oct;92(5):630-634
    Department of Surgery - Division of Vascular and Endovascular Surgery of the Clinics Hospital of the School of Medicine of the Universidade de São Paulo (HCFMUSP) - São Paulo (SP), Brazil.
    Background: The present paper aims to study the prevalence of the various manifestations of hyperhidrosis in patients who sought treatment in a specialized ambulatory in the state of São Paulo.

    Objectives: Opposite to previous studies, this paper studies the different combinations of sweating sites, not being restricted to the main complaint site of the patients, but taking into consideration secondary complaints patients may present.

    Methods: This was a retrospective approach of a database containing more than 1200 patients in which were mapped: combination of sweating sites, age of onset, age spectrum, mean age, body mass index and gender of patients. Read More

    Physiological and pathophysiological firing properties of single postganglionic sympathetic neurons in humans.
    J Neurophysiol 2017 Nov 15:jn.00004.2017. Epub 2017 Nov 15.
    University of Gothenburg.
    It has long been known from microneurographic recordings in human subjects that activity of postganglionic sympathetic axons occurs as spontaneous bursts, with muscle sympathetic nerve activity (MSNA) exhibiting strong cardiac rhythmicity via the baroreflex and skin sympathetic nerve activity (SSNA) showing much weaker cardiac modulation. Here we review the firing properties of single sympathetic neurons, obtained using highly selective microelectrodes. Individual vasoconstrictor neurons supplying muscle or skin, or sudomotor neurones supplying sweat glands, always discharge with a low firing probability (~30%) and at very low frequencies (~0. Read More

    Postoperative Harlequin Syndrome: Case Report of a Rare but Clinically Striking Condition.
    A A Case Rep 2017 Nov 9. Epub 2017 Nov 9.
    From the Departments of *Anesthesiology, †Pediatric Anesthesiology, and ‡Pediatric General Surgery, New York Medical College at Westchester Medical Center, Valhalla, New York.
    We present a case of a 2-year-old boy who underwent thoracoscopic resection of a left paraspinal mediastinal mass and developed Harlequin syndrome postoperatively. Harlequin syndrome is a rare neurological condition characterized by unilateral hyperhidrosis and erythema of the head and neck. Our discussion highlights this condition and other differential diagnoses that may present similarly in the postoperative period. Read More

    Prolonged and localized sweat stimulation by iontophoretic delivery of the slowly-metabolized cholinergic agent carbachol.
    J Dermatol Sci 2017 Nov 8. Epub 2017 Nov 8.
    Department of Electrical Engineering and Computing Science, University of Cincinnati, Cincinnati, Ohio 45221, USA.
    Background: Continuous non-invasive sampling and sensing of multiple classes of analytes could revolutionize medical diagnostics and wearable technologies, but also remains highly elusive because of the many confounding factors for candidate biofluids such as interstitial fluid, tears, saliva, and sweat. Eccrine sweat biosensing has seen a recent surge in demonstrations of wearable sampling and sensing devices. However, for subjects at rest, access to eccrine sweat is highly limited and unpredictable compared to saliva and tears. Read More

    [Axillary and perimamillary Fox-Fordyce disease (apocrine miliaria) in a 19-year-old woman].
    Hautarzt 2017 Nov 6. Epub 2017 Nov 6.
    Universitäts-Hautklinik Heidelberg, Ruprecht-Karls Universität Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland.
    Fox-Fordyce disease (FFD), also known as apocrine miliaria, is a rare and chronic skin disease characterized by itching and skin-colored, light brown or yellowish papules. FFD typically affects postpubertal young women between 13 and 35 years. The etiology is not completely known, but a hormonal component is in discussion. Read More

    Oxycodone/Naloxone Prolonged Release: A Review in Severe Chronic Pain.
    Clin Drug Investig 2017 Dec;37(12):1191-1201
    Springer, Private Bag 65901, Mairangi Bay, 0754, Auckland, New Zealand.
    Oral oxycodone/naloxone prolonged release (PR) [Targin®, Targinact®, Targiniq®] is a 12-hourly opioid receptor agonist and opioid receptor antagonist fixed-dose combination product that is approved in countries in the EU for the management of severe pain (adequately manageable only with opioid analgesics) in adults. Oral naloxone prevents oxycodone from binding to μ-receptors in the gastrointestinal (GI) tract, thereby counteracting opioid-induced constipation (OIC). In short-term (5- to 12-week) clinical trials of adults with moderate to severe, chronic pain and OIC (OXN3001, OXN3006, OXN3506), oxycodone/naloxone PR significantly improved OIC while providing noninferior analgesia relative to oxycodone PR; results were consistent between cancer and non-cancer patients in OXN3506. Read More

    THE NON-NEURONAL AND NON-MUSCULAR EFFECTS OF BOTULINUM TOXIN: A Graceful Opportunity for a Deadly Molecule to Treat a Human Disease in the Skin and Beyond.
    Br J Dermatol 2017 Oct 31. Epub 2017 Oct 31.
    Department of Dermatology, University of California, Irvine, CA, USA.
    There is growing evidence that botulinum neurotoxins (BoNTs) exhibit biological effects on various human cell types with a host of associated clinical implications. The BoNT receptors and intracellular targets are not unique for neurotransmission. They have been found in both neuronal and non-neuronal cells, but there are differences in the way BoNT binds to, and acts on neuronal vs. Read More

    Neurophysiological Measures of Efficacy and Safety for Botulinum Toxin Injection in Facial and Bulbar Muscles: Special Considerations.
    Toxins (Basel) 2017 Oct 30;9(11). Epub 2017 Oct 30.
    Department of Neuroscience, Clinical Neurophysiology, Uppsala University, 75185 Uppsala, Sweden.
    Botulinum toxin (BoNT) injections into facial and bulbar muscles are widely and increasingly used as medical treatments for cervical and facial dystonia, facial hemispasm, correction of facial palsy, hyperhidrosis, as well as cosmetic treatment of glabellar lines associated with grief and anger. Although BoNT treatment is generally considered safe, the diffusion of the toxin to surrounding muscles may result in complications, including difficulties swallowing, in a dose-dependent manner. The sensitivity of clinical examination for detecting adverse events after BoNT treatment is limited. Read More

    Acupuncture and Cutaneous Medicine: Is It Effective?
    Med Acupunct 2017 Oct;29(5):269-275
    Medical Acupuncture of Chester County, West Chester, PA.
    Background: In China, acupuncture has been used as a form of medical therapy for more than 2500 years. It is a part of traditional medical practice and is used to treat the entire spectrum of human and veterinary disease. Although dermatologic disease has received much less attention in worldwide acupuncture research than pain and musculoskeletal conditions, there is a growing body of evidence suggesting acupuncture's usefulness in this area. Read More

    Lasers and Energy-Based Devices in Men.
    Dermatol Surg 2017 Nov;43 Suppl 2:S176-S184
    *Department of Dermatology, University of California, Davis, Sacramento, California; †Laser and Skin Surgery Center of Northern California, Sacramento, California; ‡Laser and Dermatologic Surgery Center, Chesterfield, Missouri.
    Background: The demand for cosmetic treatments with lasers and energy-based devices has increased among men, but there is a dearth of literature that addresses the approach and treatment of cosmetic male patients.

    Objective: To summarize common cosmetic concerns for which male patients seek cosmetic treatments and to provide sex-specific recommendations for the lasers and energy-based devices that can be used for treatment.

    Materials And Methods: The authors conducted a literature search using the PubMed/MEDLINE and Google Scholar databases using the search terms male, men, gender, and cosmetic dermatology. Read More

    A phase 2a randomized controlled study to evaluate the pharmacokinetic, safety, tolerability and clinical effect of topically applied Umeclidinium in subjects with primary axillary hyperhidrosis.
    J Eur Acad Dermatol Venereol 2017 Oct 21. Epub 2017 Oct 21.
    Dermatology Therapeutic Area Unit, GlaxoSmithKline, Collegeville, PA, USA.
    Background: Hyperhidrosis is a common medical condition which can have a significant impact on quality of life. Umeclidinium (UMEC) is a long-acting muscarinic antagonist (LAMA) developed as a dermal formulation.

    Objectives: This 2-week, double-blind, randomized, vehicle-controlled study evaluated systemic exposure, safety and tolerability of topically administered UMEC in subjects with primary axillary hyperhidrosis. Read More

    Evaluation of patients who underwent resympathectomy for treatment of primary hyperhidrosis.
    Interact Cardiovasc Thorac Surg 2017 Nov;25(5):716-719
    Hospital Israelita Albert Einstein, São Paulo, Brazil.
    Objectives: Video thoracoscopic sympathectomy is the recommended surgical treatment for primary hyperhidrosis and has a high success rate. Despite this high success rate, some patients are unresponsive and eventually need a resympathectomy. Few studies have previously analysed exclusively the results of these resympathectomies in patients with primary hyperhidrosis. Read More

    Sialocutaneous fistula to the external auditory canal repaired with superficial parotidectomy and temporoparietal flap: A case report.
    Medicine (Baltimore) 2017 Oct;96(42):e7038
    Department of Otolaryngology-Head and Neck Surgery, Western University, London, ON, Canada.
    Rationale: Gustatory otorrhea can lead to cutaneous changes, recurrent infection, and social disruption. We present a case of a late, evolving sialocutaneous fistula to the external auditory canal, managed surgically after failing conservative therapies. This case is unique by late evolution, whereby the symptoms presented with significance 27 years after her operation and 19 years after mild symptoms initially arose. Read More

    CT-Guided, Percutaneous Ethanol Sympatholysis for Primary Hyperhidrosis.
    Cardiovasc Intervent Radiol 2017 Oct 16. Epub 2017 Oct 16.
    Division of Vascular and Interventional Radiology, The Johns Hopkins University School of Medicine, 1800 Orleans Street, Zayed 4th Flr, Baltimore, MD, 21287, USA.
    Purpose: Primary hyperhidrosis (PH) typically involves the craniofacial (CF) or axillary-palmar (AP) region. Our purpose was to determine the safety and efficacy of CT-guided sympatholysis for treating PH.

    Methods: In this prospective study, 39 consecutive patients with CF or AP PH were referred for percutaneous sympatholysis. Read More

    [Modern non-cosmetic treatment with botulinum toxins].
    Internist (Berl) 2017 Dec;58(12):1332-1340
    Neurologische Klinik und Poliklinik, Klinikum der Universität, LMU München, Marchioninistr. 15, 81377, München, Deutschland.
    Botulinum toxin has been known in medical history for a long time. The first scientific investigations and thoughts on possible indications in the treatment of muscular disorders were published by the German physician and poet Justinus Kerner in 1822. The physiological effect of botulinum toxin was identified in the middle of the twentieth century and the first clinical use was reported in 1977. Read More

    Evaluation of the quality of life of patients with primary hyperhidrosis submitted to videothoracoscopic sympathectomy.
    Rev Col Bras Cir 2017 Jul-Aug;44(4):323-327
    Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Departamento de Cirurgia Geral e Especializada, Mestrado Profissional em Técnicas Videoendoscópicas, Rio de Janeiro, RJ, Brasil.
    Objective: to evaluate the quality of life of patients undergoing video-assisted thoracoscopy for primary hyperhidrosis.

    Methods: we evaluated the patients who underwent thoracoscopic sympathectomy to treat primary hyperhidrosis by the team of thoracic surgery at the University Hospital Gaffrée and Guinle - UNIRIO between July 2004 and August 2013. It was applied a questionnaire about quality of life related to hyperhidrosis since preoperative period until one year after the surgery. Read More

    Epidemiology of hyperhidrosis in 2 population-based health care databases.
    J Am Acad Dermatol 2017 Oct 6. Epub 2017 Oct 6.
    Epidemiology Associates, LLC, Chapel Hill, North Carolina.
    Background: Population-based and clinical case reports of hyperhidrosis (HH) provide prevalence estimates that vary widely across reported studies because of differences in case ascertainment.

    Objective: In this study, we specify diagnostic, symptom, and prescription codes for HH to estimate incidence and prevalence for the United Kingdom and the United States.

    Methods: Data from UK and US health care databases were analyzed to ascertain HH cases and estimate incidence and prevalence from health care records during calendar years 2011 through 2013. Read More

    T3 versus T4 thoracoscopic sympathectomy for palmar hyperhidrosis: a meta-analysis and systematic review.
    J Surg Res 2017 Oct 15;218:124-131. Epub 2017 Jun 15.
    Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China. Electronic address:
    Background: Palmar hyperhidrosis (PH) is a benign sympathetic disorder that can adversely affect the quality of life of patients. Thoracic sympathectomy (TS) at the T3 or T4 level has been used to treat PH. We aimed to determine the optimal denervation level for TS by comparing the efficacy of T3 TS versus T4 TS in PH patients. Read More

    Resolution of generalized compensatory hyperhidrosis related to sympathectomy, after T2 sympatholysis.
    Eur J Cardiothorac Surg 2017 Dec;52(6):1231-1232
    Division of Vascular and Interventional Radiology, Department of Radiology, The Johns Hopkins University, Baltimore, MD, USA.
    Compensatory hyperhidrosis (CH) is common after sympathectomy, and most treatments are ineffective. We present a 36-year-old man whose CH was effectively treated with percutaneous sympatholysis. The patient's axillary-palmar hyperhidrosis had been treated with T3-4 sympathetic ligation. Read More

    Acromegaly with hypophosphataemia: McCune-Albright syndrome.
    BMJ Case Rep 2017 Sep 28;2017. Epub 2017 Sep 28.
    Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    A 38-year-old man presented with excessive height gain and progressive enlargement of the extremities since childhood. This was compounded by lower limb deformities over the past 5 years. On examination, his height was 196 cm, he had macroglossia, acral enlargement, seborrhoea, hyperhidrosis-suggesting acrogigantism. Read More

    A novel method to assess the potential role of sweating abnormalities in the pathogenesis of atopic dermatitis.
    Exp Dermatol 2017 Sep 23. Epub 2017 Sep 23.
    Department of Dermatology, Kyorin University School of Medicine, Mitaka city, Tokyo, Japan.
    Although atopic dry skin is believed to be caused by defects in skin genes important for maintaining skin barrier function, the role of sweat in atopic dermatitis (AD) has been apparently underestimated. Given the great capacity of sweat to maintain and increase skin hydration, defective sweating responses may be a logical place to look for changes that predispose individuals to the disease. We investigated how disease process and sweating defects progress from early asymptomatic stages to the onset of clinically apparent disease by employing the impression mould technique, which allows an accurate quantification of individual sweat gland/duct activity in relation to skin surface topography. Read More

    Quantity and quality of sweating in atopic dermatitis.
    Arch Dermatol Res 2017 Dec 21;309(10):787-793. Epub 2017 Sep 21.
    Department of Dermatology, Municipal Hospital Hietzing, Wolkersbergenstraße 1, 1130, Vienna, Austria.
    Sweat may be an important factor in triggering an exacerbation of atopic dermatitis. It was the aim of this study to evaluate a possible correlation between atopic patients and hyperhidrosis-measured by a questionnaire-and to find out whether there are qualitative differences in sweat response-measured by sudomotor activity (sympathetic skin response test, SSR). Included were 100 study participants, of whom 50 were patients with atopic dermatitis and 50 were serving as control group. Read More

    Risk reduction of long-term major adverse cardiovascular events after endoscopic thoracic sympathectomy in palmar hyperhidrosis.
    Clin Auton Res 2017 Dec 19;27(6):393-400. Epub 2017 Sep 19.
    Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, 7115R, No.325, Section 2, Cheng-Kung Road, Neihu District, Taipei City, 11490, Taiwan, ROC.
    Purpose: Palmar hyperhidrosis (PH) is excessive sweating of the palms resulting from sympathetic overactivity, and patients who undergo endoscopic thoracic sympathectomy (ETS) show reduced cardiac demand after 1 year and improved cerebral perfusion within 2-4 weeks. However, the long-term risks of major adverse cardiovascular events (MACE) following ETS remain unclear.

    Methods: We searched the Longitudinal National Health Insurance Database in Taiwan and identified PH patients (International Classification of Disease, Ninth Revision, Clinical Modification diagnostic code 708. Read More

    Pitted keratolysis - a study of various clinical manifestations.
    Int J Dermatol 2017 Nov 18;56(11):1154-1160. Epub 2017 Sep 18.
    Department of Dermatology, Venereology and Leprology, H.B.T. Medical College and Dr. R.N. Cooper Hospital, Mumbai, Maharashtra, India.
    Background: Pitted keratolysis (PK) is a common bacterial infection of skin characterized by noninflammatory superficial pits. Very few studies have focused on variations in clinical manifestations of PK. We conducted this study so that diagnosis of this treatable condition is not missed when it presents in an uncommonly perceived way. Read More

    Pachydermoperiostosis: The value of molecular diagnosis.
    Ann Dermatol Venereol 2017 Dec 12;144(12):799-803. Epub 2017 Sep 12.
    Department of Dermatology, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France; MAGEC, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France. Electronic address:
    Background: Pachydermoperiostosis is a rare autosomal recessive genetic disorder characterized by the association of periostosis and pachydermia. To date, two genes involved in prostaglandin metabolism, HPGD and SLCO2A1, have been identified.

    Patients And Methods: A 7-year-old girl presented digital clubbing of the hands and feet, curved nails, hyperhidrosis, and pachydermia, as well as eczema of the trunk and limbs. Read More

    The effect of liner design and materials selection on prosthesis interface heat dissipation.
    Prosthet Orthot Int 2017 Sep 1:309364617729923. Epub 2017 Sep 1.
    1 University College London, London, UK.
    Background And Aim: Thermal discomfort often affects prosthesis wearers and could be addressed by increasing liner thermal conductivity. This note explores a liner made from thermally conductive silicone and two additional alternative liner designs.

    Technique: Thermally conductive silicone was used to create a conductive liner and a hybrid liner. Read More

    Meta-analysis: Risk of hyperhidrosis with second-generation antidepressants.
    Depress Anxiety 2017 Dec 7;34(12):1134-1146. Epub 2017 Sep 7.
    Department of Psychiatry, Yale University, New Haven, CT, USA.
    Background: Our goal was to quantify the risk of hyperhidrosis associated with commonly used antidepressant agents and examine the impact of medication class, pharmacodynamics, and dose on risk of hyperhidrosis.

    Methods: We conducted a PubMed search to identify all double-blind, randomized, placebo-controlled trials examining the efficacy of second-generation antidepressant medications in the treatment of adults with a depressive disorder, anxiety disorders, or obsessive-compulsive disorder. We used a random-effects meta-analysis to examine the pooled risk ratio of hyperhidrosis reported as a side effect in adults treated with second-generation antidepressants compared to placebo. Read More

    Does endoscopic thoracic sympathectomy through clipping procedure have early effects on electrocardiographic parameters?
    Indian J Med Res 2017 Apr;145(4):498-502
    Department of Thoracic Surgery, GATA Haydarpasa Training Hospital, Istanbul, Turkey.
    Background & Objectives: Hyperhidrosis is a pathologic condition of excessive sweating in amounts greater than physiologic needs. Endoscopic thoracic sympathectomy (ETS) is a globally accepted treatment modality for primary palmar and axillary hyperhidrosis. ETS also has distinctive effects on the heart, circulatory and respiratory systems. Read More

    Recovery of sympathetic nerve function after lumbar sympathectomy is slower in the hind limbs than in the torso.
    Neural Regen Res 2017 Jul;12(7):1177-1185
    The Graduate School of Southern Medical University, Guangzhou, Guangdong Province, China.
    Local sympathetic denervation by surgical sympathectomy is used in the treatment of lower limb ulcers and ischemia, but the restoration of cutaneous sympathetic nerve functions is less clear. This study aims to explore the recovery of cutaneous sympathetic functions after bilateral L2-4 sympathectomy. The skin temperature of the left feet, using a point monitoring thermometer, increased intraoperatively after sympathectomy. Read More

    Botulinum neurotoxin injection for the treatment of epiphora in nasolacrimal duct obstruction.
    J Fr Ophtalmol 2017 Oct 25;40(8):661-665. Epub 2017 Aug 25.
    Department of Neuroradiology, Quinze-Vingts National Hospital of Ophthalmology, 28, rue de Charenton, 75012 Paris, France.
    Purpose: Retrospective long-term study to evaluate the efficacy of botulinum neurotoxin A (BoNT/A) therapy for epiphora due to non-surgical nasolacrimal duct obstruction.

    Introduction: BoNT/A has been used successfully since 2000 in axillary hyperhidrosis to reduce secretory disorders. Some isolated cases of hyperlacrimation or crocodile tear syndrome have been treated on this basis. Read More

    A case report: Glycopyrrolate for treatment of exercise-induced hyperhidrosis.
    SAGE Open Med Case Rep 2017 8;5:2050313X17721601. Epub 2017 Aug 8.
    Sports Medicine Clinic, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
    Objective: Hyperhidrosis can cause dehydration and exercise intolerance. There are several case reports of extremely high sweat rates in athletes. We present as case report of a 17-year-old male with the highest sweat rate recorded in the literature (5. Read More

    Iodine-Starch test for assessment of hyperhidrosis in amputees, evaluation of different methods of application.
    Disabil Rehabil 2017 Aug 21:1-5. Epub 2017 Aug 21.
    a Division of Physical Medicine and Rehabilitation , University of Utah School of Medicine , Salt Lake City , UT , USA.
    Purpose: Hyperhidrosis is a common problem for amputees. The iodine-starch test is frequently used to assess hyperhidrosis, but a method for its application has not been described for amputees.

    Methods: We performed an unblinded comparison of the iodine-starch test using various methods to protect the prosthesis in 10 prosthetic limb users with hyperhidrosis. Read More

    The Etiology of Primary Hyperhidrosis: A Systematic Review.
    Clin Auton Res 2017 Dec 19;27(6):379-383. Epub 2017 Aug 19.
    Department of Cardiothoracic Surgery, Odense University Hospital, Odense, 5000, Denmark.
    Purpose: Primary hyperhidrosis is a pathological disorder of unknown etiology, affecting 0.6-5% of the population, and causing severe functional and social handicaps. As the etiology is unknown, it is not possible to treat the root cause. Read More

    The curative effect of liposuction curettage in the treatment of bromhidrosis: A meta-analysis.
    Medicine (Baltimore) 2017 Aug;96(33):e7844
    aDepartment of Plastic Surgery, China-Japan Union Hospital, Jilin University, Changchun bDepartment of Orthopaedics, Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China.
    Background: We aimed to understand the curative effect of liposuction curettage (LC) in the treatment of bromhidrosis.

    Methods: Relevant studies published before January 2017were searched from the PubMed, Embase, Cochrane Library, Wanfang, VIP, and China National Knowledge Infrastructure databases. Parameters including recurrence, complications, complete response, and overall response were assessed. Read More

    A novel organotypic 3D sweat gland model with physiological functionality.
    PLoS One 2017 10;12(8):e0182752. Epub 2017 Aug 10.
    Henkel AG & Co. KGaA, Düsseldorf, Germany.
    Dysregulated human eccrine sweat glands can negatively impact the quality-of-life of people suffering from disorders like hyperhidrosis. Inability of sweating can even result in serious health effects in humans affected by anhidrosis. The underlying mechanisms must be elucidated and a reliable in vitro test system for drug screening must be developed. Read More

    Keratin 17 Mutations in Four Families from India with Pachyonychia Congenita.
    Indian J Dermatol 2017 Jul-Aug;62(4):422-426
    School of Life Sciences, Division of Biological Chemistry and Drug Discovery, Dermatology and Genetic Medicine, University of Dundee, Dundee, UK.
    Pachyonychia congenita (PC) is a rare autosomal dominant genetic skin disorder due to a mutation in any one of the five keratin genes, KRT6A, KRT6B, KRT6C, KRT16, or KRT17. The main features are palmoplantar keratoderma, plantar pain, and nail dystrophy. Cysts of various types, follicular hyperkeratosis, oral leukokeratosis, hyperhidrosis, and natal teeth may also be present. Read More

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