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    1 OF 86

    Klippel-Trenauney syndrome with axillary hyperhidrosis.
    Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.
    MD Program, Tufts University School of Medicine, Boston, Massachusetts,.
    Klippel-Trenaunay syndrome (KTS) is a rare, clinically variable congenital disorder involving capillary malformations, soft tissue or bone hypertrophy, and venous malformations or varicose veins. We report a 28-year-old man who presented with a hypertrophic right arm as well as markedly increased ipsilateral axillary hyperhidrosis and erythematous patches on the back, chest, and arm. This case of KTS is unusual because our patient presented with a markedly increased unilateral axillary hyperhidrosis ipsilateral to the hypertrophic limb. Read More

    Early-Onset Shapiro Syndrome Variant Treated with Pizotifen: A Case Report.
    Neurodiagn J 2017 ;57(2):139-146
    a Child Neuropsychiatry Unit , Giannina Gaslini Pediatric Institute , Genoa , Italy.
    Shapiro Syndrome is a rare entity defined by the triad of recurrent spontaneous hypothermia, hyperhidrosis, and agenesis of the corpus callosum. Fewer than 100 cases have been reported so far and there are only few cases without a complete agenesis of corpus callosum ("Shapiro Syndrome Variant"). In this article, we report the clinical, electroencephalographic, and neuroimaging data of a patient with early-onset Shapiro Syndrome Variant. Read More

    Skin findings in autoimmune and nonautoimmune thyroid disease with respect to thyroid functional status and healthy controls.
    Turk J Med Sci 2017 Jun 12;47(3):764-770. Epub 2017 Jun 12.
    Department of Dermatology, İstanbul Medeniyet University, Göztepe Research and Training Hospital, İstanbul, Turkey.
    Background/aim: Thyroid disorders are associated with a wide variety of skin disorders that respond to treatment of hormone imbalance in most cases and thus are of vital importance to dermatologists. This study aimed to evaluate skin findings associated with autoimmune and nonautoimmune thyroid disease with respect to thyroid functional status and healthy controls.

    Materials And Methods: A total of 300 consecutive patients with either autoimmune (n = 173) or nonautoimmune (n = 127) thyroid disease and 100 healthy control subjects were included in this cross-sectional study. Read More

    Botulinum Toxin Off-Label Use in Dermatology: A Review.
    Skin Appendage Disord 2017 Mar 1;3(1):39-56. Epub 2017 Feb 1.
    Dermatology Unit, Department of Clinical and Molecular Sciences, United Hospital of Ancona, Polytechnic Marche University, Ancona, Italy.
    Background: Botulinum toxin is a neurotoxin produced by the bacterium Clostridium botulinum which causes a flaccid muscle paralysis. It is currently used for aesthetic treatments and in the focal hyperhidrosis. Recently, botulinum toxin has also been used experimentally in many other dermatological conditions with good results. Read More

    [Assessment of the radial and ulnar arteries hemodynamic changes by ultrasound in patients with primary palmar hyperhidrosis after thoracic sympathetic block].
    Zhonghua Yi Xue Za Zhi 2017 Jun;97(22):1729-1733
    Department of Anesthesiology and Pain Medicine, the First Hospital of Jiaxing City, Zhejiang Province, Jiaxing 314001, China.
    Objective: To evaluate the value of radial and ulnar arteries hemodynamic changes by ultrasound in patients with primary palmar hyperhidrosis after thoracic sympathetic block. Methods: This was a prospective study, from January 2016 to September 2016, 23 patients with primary palmar hyperhidrosis were admitted to the First Hospital of Jiaxing City, Zhejiang Province, 92 arteries of these patients who underwent thoracic sympathetic block were enrolled into this study. Diameters, peak systolic velocity (PSV), end diastolic velocity (EDV) and resistive index (RI) of the radial and ulnar arteries were examined one day before and after the operation by color Doppler ultrasound. Read More

    The impact of hyperhidrosis on patients' daily life and quality of life: a qualitative investigation.
    Health Qual Life Outcomes 2017 Jun 8;15(1):121. Epub 2017 Jun 8.
    Institute of Medicines Development, Duffryn House, Cardiff, CF, 23 6NP, UK.
    Background: An understanding of the daily life impacts of hyperhidrosis and how patients deal with them, based on qualitative research, is lacking. This study investigated the impact of hyperhidrosis on the daily life of patients using a mix of qualitative research methods.

    Methods: Participants were recruited through hyperhidrosis patient support groups such as the Hyperhidrosis Support Group UK. Read More

    Dependent Erythema of the Legs Associated With Mild Autonomic Nervous System Dysfunction.
    J Cutan Med Surg 2017 Jun 1:1203475417714801. Epub 2017 Jun 1.
    2 Department of Medicine, Memorial University, St John's, NL, Canada.
    Introduction: Dependent erythema or rubor is an erythematous discoloration of the limbs, most commonly associated with peripheral artery disease. We present a case of florid dependent erythema, associated with additional autonomic symptoms.

    Methods: Examination and full workup of a 16-year-old healthy girl with an 8-year history of dependent erythema, chronic diarrhea, and mild hyperhidrosis. Read More

    Comparison of the Long-Term Results of R3 and R4 Sympathicotomy for Palmar Hyperhidrosis.
    Korean J Thorac Cardiovasc Surg 2017 Jun 5;50(3):197-201. Epub 2017 Jun 5.
    Department of Thoracic and Cardiovascular Surgery, Yeungnam University College of Medicine.
    Background: Video-assisted thoracoscopic sympathicotomy has been determined to be the best way to treat palmar hyperhidrosis. However, satisfaction with the surgical outcomes decreases with the onset of compensatory hyperhidrosis (CH) over time. The ideal level of sympathicotomy is controversial. Read More

    Mahuannin B an adenylate cyclase inhibitor attenuates hyperhidrosis via suppressing β2-adrenoceptor/cAMP signaling pathway.
    Phytomedicine 2017 Jul 10;30:18-27. Epub 2017 Mar 10.
    State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China. Electronic address:
    Background: Based on the traditional application of traditional Chinese Medicines (TCMs), Ephedra Herba (EH) is used to cure cold fever by inducing sweating, whereas Ephedra Radix (ER) is used to treat hyperhidrosis. Although they come from the same plant, Ephedra sinica Stapf, but have play opposing roles in clinical applications. EH is known to contain ephedrine alkaloids, which is the driver of the physiological changes in sweating, heart rate and blood pressure. Read More

    Oxybutynin as an alternative treatment for hyperhidrosis.
    An Bras Dermatol 2017 Mar-Apr;92(2):217-220
    Departament of Drugs and Medicines of the Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp) - Botucatu (SP), Brazil.
    Hyperhidrosis is the excessive production of sweating, which can be primary and focal or secondary to various pathologies. The exact cause of primary focal hyperhidrosis is still unknown, although a genetic basis is recognized, and its prevalence varies from 1% to 2.8%. Read More

    Comparative Study of Efficacy and Safety of Botulinum Toxin a Injections and Subcutaneous Curettage in the Treatment of Axillary Hyperhidrosis.
    J Cutan Aesthet Surg 2017 Jan-Mar;10(1):33-39
    Department of Dermatology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.
    Background: Primary focal axillary hyperhidrosis is a chronic distressing disorder affecting both the sexes. When the condition is refractory to conservative management, we should go for more promising therapies like intradermal botulinum toxin A (BtxA) injections in the axilla, and surgical therapies like subcutaneous curettage of sweat glands.

    Aims And Objectives: The aim of this study is to compare the efficacy, safety and duration of action of intradermal BtxA injections in one axilla and subcutaneous curettage of sweat glands in the other axilla of the same patient with axillary hyperhidrosis. Read More

    Perfusion Index: An Indicator of Success During Endoscopic Thoracic Sympathectomy for Hyperhidrosis.
    Ann Thorac Surg 2017 May 17. Epub 2017 May 17.
    Division of Thoracic and Cardiovascular Surgery, University of Florida, Gainesville, Florida; Department of Anesthesiology, University of Florida, Gainesville, Florida.
    Background: Endoscopic thoracic sympathectomy (ETS) is indicated for refractory hyperhidrosis. The pulse oximetry-derived perfusion index (PI) quantifies pulsatile blood flow at the oximeter. Thoracic sympathectomy increases blood flow; thus we postulate it will reliably increase PI. Read More

    Electro-Acupuncture at Zusanli Acupoint (ST36) Suppresses Inflammation in Allergic Contact Dermatitis Via Triggering Local IL-10 Production and Inhibiting p38 MAPK Activation.
    Inflammation 2017 May 10. Epub 2017 May 10.
    Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion, Hubei University of Chinese Medicine, 1 Huangjiahu West Road, Hongshan District, Wuhan, Hubei, 430065, China.
    Acupuncture has shown beneficial effect in the treatment of multiple dermatologic conditions including dermatitis, pruritus, urticaria, and hyperhidrosis; however, the detailed mechanisms are still kept unclear. This study aimed to investigate if electro-acupuncture (EA) treatment prevents 2,4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis (ACD) in rats and explore its underlying mechanisms. ACD was induced by sensitizing and challenging with DNFB topically. Read More

    Clinical effect of montelukast sodium combined with inhaled corticosteroids in the treatment of OSAS children.
    Medicine (Baltimore) 2017 May;96(19):e6628
    Department of Otolaryngology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Chongqing, China.
    This study was designed to investigate the clinical effect of montelukast sodium combined with inhaled corticosteroids in the treatment of children with obstructive sleep apnea syndrome (OSAS).One hundred ninety-five children were enrolled and divided into 3 groups: groups A, B, and C; the group A (oral use of montelukast sodium), group B (nasal spray of mometasone furoate), and group C (oral use of montelukast sodium + nasal spray of mometasone furoate). Telephone questionnaire surveys were carried out. Read More

    Videothoracoscopic Sympathectomy Results after Oxybutynin Chloride Treatment Failure.
    Ann Vasc Surg 2017 May 3. Epub 2017 May 3.
    Department of Vascular Surgery, University of São Paulo, Sao Paulo, Brazil.
    Background: Videothoracoscopy sympathectomy (VATS) is the only definitive treatment for primary hyperhidrosis (HH). Since 2007, in our institution, patients with HH were initially treated with oxybutynin chloride to avoid VATS and reduce compensatory hyperhidrosis incidence with good results. The aim of this study was to analyze the surgical response of patients suffering from essential hyperhidrosis after failure of oxybutynin chloride treatment. Read More

    Botulinum toxin-induced acute anterior uveitis in a patient with Behçet's disease under infliximab treatment: a case report.
    J Med Case Rep 2017 May 4;11(1):124. Epub 2017 May 4.
    Department of Ophthalmology, Asai Hospital, 178-1 Yakata-cho, Seto, Aichi, 489-0866, Japan.
    Background: Injections of lipopolysaccharide in animal models generate acute anterior uveitis (also known as endotoxin-induced uveitis), but the effects of lipopolysaccharide injection are unknown in humans. We describe an unusual case in which acute anterior uveitis was dramatically activated subsequent to botulinum toxin injection in a patient with Behçet's disease but the acute anterior uveitis was satisfactorily attenuated by infliximab.

    Case Presentation: A 53-year-old Japanese man had normal ocular findings at his regularly scheduled appointment. Read More

    The clinical features of 590 patients with brucellosis in Xinjiang, China with the emphasis on the treatment of complications.
    PLoS Negl Trop Dis 2017 May 1;11(5):e0005577. Epub 2017 May 1.
    Department of Infection Disease Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
    Background: This study aims to analyze the clinical characteristics and treatment outcomes of 590 patients with brucellosis in Xinjiang, China.

    Methodology And Principal Findings: The clinical characteristics, laboratory findings, complications and prognosis of 590 patients infected with brucellosis were retrospectively analyzed. These patients had a mean age of 44. Read More

    Thoracic sympathectomy for hyperhidrosis: from surgical indications to clinical results.
    J Thorac Dis 2017 Apr;9(Suppl 3):S178-S192
    Thoracic Surgery Department, Hospital Federal do Andaraí, Rio de Janeiro, Brazil.
    Sympathectomy and its variations have been performed in thoracic surgery for more than 100 years. However, its indications have undergone profound modifications in this period. Likewise, since then the surgical technique has also evolved dramatically up to the minimally invasive techniques worldwide accessible in present days. Read More

    Comparison of T2 and T3 sympathectomy for compensatory sweating on palmar hyperhidrosis.
    Medicine (Baltimore) 2017 Apr;96(16):e6697
    Department of Thoracic Surgery, Karadeniz Technical University Medical School, Trabzon, Turkey.
    Background: An otherwise successfully performed endoscopic thoracic sympathectomy (ETS) to treat palmar hyperhidrosis (PH) often has a serious side effect: compensatory sweating (CS). This side effect occurs in other parts of the body to a disturbing extent. The objective of this study is to determine whether there is a relationship between the level of ETS performed on patients with PH, and the occurrence and severity of postoperational CS. Read More

    Eccrine Nevus Presenting with Umbilical Discharge: A Case Report and Review of the Literature.
    Case Rep Dermatol Med 2017 21;2017:9761843. Epub 2017 Mar 21.
    Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Eccrine nevus is a rare skin lesion with protean manifestations like hyperhidrosis, discolored nodules, papules, and so forth, which has been reported in various anatomic parts of the body including the forearm, leg, thigh, back, and coccyx. Our patient was a 26-year-old male, who presented with increasing colorless and odorless episodic umbilical discharge. First impression for the patient was an umbilical sinus and the patient underwent surgery. Read More

    Confirmatory factor analysis of the Sleep Disturbance Scale for Children (SDSC) in a clinical sample of children and adolescents.
    J Sleep Res 2017 Apr 12. Epub 2017 Apr 12.
    School of Psychological Science, University of Western Australia, Crawley, WA, Australia.
    The Sleep Disturbance Scale for Children was developed as a parent-report measure to screen for sleep disturbances within the preceding 6 months. Notably, the scale was developed using a sample of typically developing children and children with sleep disorders. The aim of this study was to factor analyse the Sleep Disturbance Scale for Children using a clinical sample of children with a range of neuropsychological conditions and co-morbidities, and determine whether the original six-factor structure was retained. Read More

    Optimal targeting of sympathetic chain levels for treatment of palmar hyperhidrosis: an updated systematic review.
    Surg Endosc 2017 Apr 7. Epub 2017 Apr 7.
    Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan, 430030, Hubei, China.
    Background: Palmar hyperhidrosis involves excessive sweating of the palms, with no known etiology. Endoscopic thoracic sympathectomy (ETS) is a safe and effective treatment for palmar hyperhidrosis, but compensatory hyperhidrosis is a common complication after ETS, leading to reduced patient satisfaction and postoperative quality of life. However, the appropriate level of the sympathetic chain to target with ETS to achieve maximum efficacy and reduce the risk of compensatory hyperhidrosis (CH) is controversial. Read More

    New Uses of AbobotulinumtoxinA in Aesthetics.
    Aesthet Surg J 2017 May;37(suppl_1):S45-S58
    Dr Schlessinger is a dermatologist and cosmetic surgeon in private practice in Omaha, NE. Dr Gilbert is a dermatologist in private practice in Brooklyn, NY. Dr Cohen is a dermatologist in private practice in Greenwood Village, CO. Dr Kaufman is dermatologist in private practice in Miami, FL.
    BotulinumtoxinA (BoNT-A) is now widely established for the main approved indication of reducing glabellar lines, and is also widely used off-label to improve the appearance of wrinkles and lines in other parts of the face. The number of aesthetic procedures continues to increase as the patient population becomes more diverse, in particular with increasing numbers of people of color and men. Further developments in treatment may continue to expand the audience for BoNT-A by making procedures more comfortable and by delivering a more natural, less static appearance. Read More

    AbobotulinumtoxinA: A 25-Year History.
    Aesthet Surg J 2017 May;37(suppl_1):S4-S11
    Dr Monheit is a Dermatologist, Departments of Dermatology and Ophthalmology, University of Alabama at Birmingham, Birmingham, AL. Dr Pickett is Director and Founder of Toxin Science Limited, Wrexham, UK; and an Adjunct Professor at the Botulinum Research Center, Institute of Advanced Sciences, Dartmouth, MA.
    During the late 1960s and early 1970s, Alan Scott showed that intramuscular injections of botulinum toxin (BoNT) corrected nonaccommodative strabismus without resorting to surgery. The UK doctors who trained with Scott soon realized the significant potential offered by BoNT type A as a therapeutic option for several difficult-to-treat diseases. This led to a collaboration between these pioneering clinicians and the Centre for Applied Microbiology and Research at Porton Down, United Kingdom, and, in turn, to the development and commercialization of abobotulinumtoxinA as Dysport (Dystonia/Porton Down; Ipsen Biopharm Ltd. Read More

    Percutaneous CT-Guided Sympathicolysis with Radiofrequency for the Treatment of Palmar Hyperhidrosis.
    J Vasc Interv Radiol 2017 Jun 30;28(6):877-885. Epub 2017 Mar 30.
    Radiology Service, Clinica Universidad de Navarra, Pamplona, Spain.
    Purpose: To evaluate the benefits of computed tomography (CT)-guided percutaneous sympathicolysis with radiofrequency in patients with primary palmar hyperhidrosis (PPHH) in terms of safety, patient satisfaction, and short- and long-term efficacy.

    Materials And Methods: A total of 139 procedures in 108 patients (mean age, 29.89 y ± 10. Read More

    Occupational mercury vapour poisoning with a respiratory failure, pneumomediastinum and severe quadriparesis.
    SAGE Open Med Case Rep 2017 23;5:2050313X17695472. Epub 2017 Feb 23.
    Department of Anaesthesiology and Intensive Therapy, Wroclaw Medical University, Wroclaw, Poland.
    Objectives: Despite restrictions, mercury continues to pose a health concern. Mercury has the ability to deposit in most parts of the body and can cause a wide range of unspecific symptoms leading to diagnostic mistakes.

    Methods And Results: We report the case of severe mercury vapour poisoning after occupational exposure in a chloralkali plant worker that resulted in life-threatening respiratory failure, pneumomediastinum and quadriparesis. Read More

    The PARP Inhibitor Veliparib Can Be Safely Added to Bendamustine and Rituximab and Has Preliminary Evidence of Activity in B-Cell Lymphoma.
    Clin Cancer Res 2017 Mar 17. Epub 2017 Mar 17.
    Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, New York.
    Purpose: The PARP inhibitor veliparib enhances the cytotoxicity of alkylating agents. This phase I study evaluated veliparib with the bifunctional alkylator bendamustine (VB) in patients with relapsed/refractory lymphoma, multiple myeloma, and solid malignancies, with a cohort expansion of VB with rituximab (VBR) in patients with B-cell lymphomas.Experimental Design: This dose-escalation study evaluated safety, pharmacokinetics, and preliminary efficacy of veliparib (20-400 mg twice a day, days 1-7 of 28-day cycle) and bendamustine (70 and 90 mg/m(2) intravenously, days 1 and 2). Read More

    Randomized, Placebo- and Active-Controlled Crossover Study of the Safety and Efficacy of THVD-102, a Fixed-dose Combination of Oxybutynin and Pilocarpine, in Subjects With Primary Focal Hyperhidrosis.
    J Drugs Dermatol 2017 Feb;16(2):127-132
    Background: While muscarinic antagonists (anticholinergics) have shown efficacy in treating primary focal hyperhidrosis (PFH), side effects - most commonly dry mouth - are intolerable for most patients. THVD-102, a fixed-dose combination product has been developed combining oxybutynin, a muscarinic antagonist, and pilocarpine, a muscarinic agonist. The pilocarpine is at a dose level and release profile optimized to correct salivary flow impaired by oxybutynin yet not interfere with the therapeutic muscarinic antagonist effect of oxybutynin upon the sweat glands. Read More

    Efficacy and safety of escitalopram in treatment of severe depression in Chinese population.
    Metab Brain Dis 2017 Jun 15;32(3):891-901. Epub 2017 Mar 15.
    Xi'an Janssen Pharmaceutical Ltd, Beijing, China.
    Severe depression accounts for one-third of depressed patients. Increasing severity of depression usually hinders patients from achieving remission. This study evaluated the efficacy and safety of escitalopram in acute-phase treatment of severe major depressive disorder (MDD). Read More

    Pourfour du Petit Syndrome Associated With Right Eye Pressure.
    Headache 2017 Jun 13;57(6):937-942. Epub 2017 Mar 13.
    Garibay is a medical student-so just medical student, Baylor College of Medicine, Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA.
    Pourfour du Petit (PDP) syndrome is a rare disorder characterized by ipsilateral mydriasis, eyelid retraction, and hemifacial hyperhidrosis caused by hyperactivity of the ipsilateral oculosympathetic pathway. A case is presented of PDP syndrome associated with likely ipsilateral occipital neuralgia. We review the causes and co-morbidities and the clinical features of PDP. Read More

    Microwave Treatment for Axillary Hyperhidrosis and Bromhidrosis.
    Actas Dermosifiliogr 2017 Jun 9;108(5):418-422. Epub 2017 Mar 9.
    Clínica Ruber y Clínica Dermatológica Internacional, Madrid, España.
    Axillary hyperhidrosis (AH) and bromhidrosis are common causes of consultation in dermatology. Currently, the most widely prescribed treatment for AH is botulinum toxin, a very effective but temporary option; it is totally ineffective in bromhidrosis. Sympathectomy is an increasingly infrequent choice of treatment due to the high incidence of compensatory hyperhidrosis. Read More

    R3 versus R4 Thoracoscopic Sympathectomy for Severe Palmar Hyperhidrosis.
    Thorac Cardiovasc Surg 2017 Mar 10. Epub 2017 Mar 10.
    Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, JiangXi, China.
    Background Thoracoscopic sympathectomy (TS) was the preferred surgical treatment for palmar hyperhidrosis (PH), but postoperative complications such as compensatory sweating (CS) were common. This study was projected to compare R3 versus R4 TS for treating severe PH. Methods From April 2009 and March 2015, 106 consecutive patients with severe PH underwent bilateral R3 (n = 62) or R4 (n = 44) TS at The Second Affiliated Hospital of Nanchang University. Read More

    Influence of Body Mass Index on Compensatory Sweating in Patients after Thoracic Sympathectomy due to Palmar Hyperhidrosis.
    Thorac Cardiovasc Surg 2017 Mar 10. Epub 2017 Mar 10.
    Department of General, Endocrine and Transplant Surgery, Gdanski Uniwersytet Medyczny, Ringgold Standard Institution, Gdansk, Poland.
    Background Thoracic sympathectomy (TS) is one of the most effective methods of treatment of primary hyperhidrosis. One of the side effects of this procedure is compensatory sweating (CS). Objective The aim of our study was to evaluate the influence of body mass index (BMI) on CS in patients after TS due to palmar hyperhidrosis. Read More

    A systematic review of microwave-based therapy for axillary hyperhidrosis.
    J Cosmet Laser Ther 2017 Mar 10:1-8. Epub 2017 Mar 10.
    b Department of Dermatology , Shuang Ho Hospital, Taipei Medical University , Taipei , Taiwan.
    Objective: To systematically analyse the literature on the use of the microwave-based device for subdermal thermolysis of the axilla and its efficacy for the treatment of axillary hyperhidrosis.

    Materials And Methods: A systematic review was conducted using PubMed, Embase, SCOPUS and Cochrane databases on 2 June 2016. The inclusion criteria including: (1) studies with human subjects, (2) full-text articles published in English, (3) a microwave-based device used to treat axillary hyperhidrosis and (4) trials that precisely evaluated axillary hyperhidrosis. Read More

    A systematic review and meta-analysis of T2, T3 or T4, to evaluate the best denervation level for palmar hyperhidrosis.
    Sci Rep 2017 Dec 9;7(1):129. Epub 2017 Mar 9.
    Department of Cardiothoracic surgery, The second affiliated hospital of Nanchang University, Nanchang, China.
    We systematically reviewed and compared the clinical outcomes of thoracoscopic sympathectomy (TS) at different denervation levels for palmar hyperhidrosis. We searched PubMed, Ovid MEDLINE, EMBASE, Web of Science, ScienceDirect, the Cochrane Library, Scopus and Google Scholar for relevant studies published during 1990-2016. Symptom resolution, patient satisfaction, compensatory sweating (CS), recurrence, dry hands and gustatory sweating were assessed. Read More

    Comparison between high and low levels thoracic sympathectomy for the treatment of palmar and axillary primary hyperhidrosis: systematic review and meta-analysis.
    Rev Col Bras Cir 2016 Dec;43(6):486-492
    Medical School, University of Marília, Marília, São Paulo, Brazil.
    Primary hyperhidrosis (PH) is a condition that has a great impact on affected individuals' quality of life, regardless of its location. Its surgical treatment is done through thoracic sympathectomy performed by videothoracoscopy. Standardization of the technique includes section of the sympathetic trunk at different levels, according to the site of symptoms. Read More

    Methadone-Induced Hyperhidrosis Treated With Oxybutynin.
    J Addict Med 2017 May/Jun;11(3):237-238
    Department of Psychiatry, Metropolitan Hospital Center, New York Medical College, New York, NY.
    Objectives: This case report aims to help healthcare providers and methadone clinic patients to recognize one of the less recognized adverse effects of methadone, hyperhidrosis, and to suggest oxybutynin as a possible solution.

    Methods: A 35-year-old man on methadone maintenance therapy presented with excessive sweating, which began promptly after methadone was introduced. Urine toxicology was conducted every 2 weeks to rule out other illicit substances that may have contributed to the sweating. Read More

    Osteopathic Manipulative Treatment in the Management of Isaacs Syndrome.
    J Am Osteopath Assoc 2017 Mar;117(3):194-198
    Isaacs syndrome is a rare neuromuscular disorder characterized by chronic muscle stiffness, cramping, fasciculations, myokymia, and hyperhidrosis. Pathogenesis includes autoimmunity, paraneoplastic disorders, genetic predisposition, or toxin exposure. There is no known cure for Isaacs syndrome. Read More

    Botulinum toxin in the management of head and neck disorders.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Apr 7;123(4):419-428. Epub 2016 Dec 7.
    Department of Oral Medicine and Radiology, New Horizon Dental College and Research Institute, Sakri, Bilaspur, India.
    Botulinum toxin is a polypeptide protoxin synthesized by Clostridium botulinum that results in localized reduction of muscle activity by inhibiting acetylcholine release at the neuromuscular junction. In 2004, the US Food and Drug Administration approved its application in the treatment of various medical conditions, such as facial wrinkles, strabismus, cervical dystonia, blepharospasm, and hyperhidrosis. Later, its application extended to improving dental esthetics and gummy smile. Read More

    Drug safety and adverse drug reaction reporting behavior related to outpatient opioid replacement therapy: Results from a survey among physicians.
    J Subst Abuse Treat 2017 Mar 14;74:7-15. Epub 2016 Dec 14.
    University of Ulm, Department of Psychiatry and Psychotherapy III, Leimgrubenweg 12-14, 89075 Ulm, Germany.
    To study drug safety and the reporting behavior of adverse drug reactions (ADR) related to agents used for opioid replacement therapy (ORT) we conducted a cross-sectional questionnaire-based telephone survey among physicians who provide outpatient ORT in Germany (n=176; response rate=55.7%). Most respondents (n=97/55. Read More

    Initial study of transdermal oxybutynin for treating hyperhidrosis.
    J Dermatol 2017 Jun 20;44(6):717-720. Epub 2017 Jan 20.
    Dermatology Department, Hospital Costa del Sol, Marbella, Málaga, Spain.
    Oral oxybutynin for treating hyperhidrosis is effective and safe. Its side-effects are mild but frequent so we consider whether transdermal oxybutynin (considered to have a better side-effect profile) could be an alternative for treating hyperhidrosis. During 2015, a prospective study was conducted. Read More

    [Fabry disease].
    Ann Dermatol Venereol 2017 Feb 16;144(2):137-146. Epub 2017 Jan 16.
    Département de dermatologie, Hôpital Hôtel-Dieu de France, Faculté de médecine, Université Saint-Joseph, Beyrouth, Liban.
    Fabry disease, also known as Anderson-Fabry disease or angiokeratoma corporis diffusum universale, is an X-linked recessive form of sphingolipidosis caused by total or partial deficiency of the lysosomal hydrolase, alpha-galactosidase A. From the youngest age, it results in a gradual ubiquitous build-up of glycosphingolipids that are not degraded by the missing enzyme. Cutaneous, neurological, nephrologic, cardiac, gastrointestinal, ophthalmological, respiratory, cochleovestibular and haematological involvement are responsible for increased mortality and significant impairment of quality of life in subjects affected by the disease. Read More

    Palmar hyperhidrosis: clinical, pathophysiological, diagnostic and therapeutic aspects.
    An Bras Dermatol 2016 Nov-Dec;91(6):716-725
    Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp) - Botucatu (SP), Brazil.
    Palmar hyperhidrosis affects up to 3% of the population and inflict significant impact on quality of life. It is characterized by chronic excessive sweating, not related to the necessity of heat loss. It evolves from a localized hyperactivity of the sympathetic autonomic system and can be triggered by stressful events. Read More

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