4,784 results match your criteria Hyperhidrosis


Recurrent arterial thrombosis in a patient with Fabry disease: case report.

J Vasc Bras 2020 Mar 10;19:e20190096. Epub 2020 Mar 10.

Faculdade Ingá, Departamento de Medicina, Maringá, PR, Brasil.

Fabry disease is a rare disease, defined as an X-linked lysosomal deposition disease that presents with multisystemic symptoms, including vascular impairment with thrombotic events. A 57-year-old female patient diagnosed with Fabry disease 11 years previously, presented with hyperhidrosis, hypoacusis, and angiokeratoma on the hands. Her previous pathological history included an episode of ischemic stroke before the age of 40 years and chronic acute thrombosis in the right lower limb, 1 year previously, which had been treated with stent angioplasty, with temporary improvement followed by recent relapse of the condition. Read More

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http://dx.doi.org/10.1590/1677-5449.190096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244207PMC

Something to Sweat About: Two Cases of Dupilumab-Induced Hyperhidrosis and Bromhidrosis.

Allergy Rhinol (Providence) 2020 Jan-Dec;11:2152656720927703. Epub 2020 May 20.

Department of Pulmonary & Critical Care, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

Introduction: Atopic dermatitis (AD, eczema) is familial chronic inflammatory skin disease of complex etiology and increasing prevalence. Dupilumab is an IL-4 receptor subunit alpha (IL-4Rα) antagonist that is the first Food and Drug Administration-approved biological therapy for moderate-to-severe adult AD inadequately controlled with topical therapies. Adverse effects reported in the literature include injection site reactions, conjunctivitis, headache, and nasopharyngitis. Read More

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http://dx.doi.org/10.1177/2152656720927703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241203PMC

Aluminium salt-based antiperspirant coated prosthesis liners do not suppress local sweating during moderate intensity exercise in hot and temperate conditions.

J Sci Med Sport 2020 May 17. Epub 2020 May 17.

Thermal Ergonomics Laboratory, Faculty of Health Sciences, University of Sydney, Australia; Charles Perkins Centre, University of Sydney, Australia.

Objective: To determine whether coating prosthesis liners with a 5% aluminium zirconium tetrachlorohydrate antiperspirant solution (AZCH) reduces local sweating on the thigh.

Design: Double-blinded counter-balanced crossover design METHODS: Fourteen able-bodied participants (age: 28±5 y; body mass: 73.9±7. Read More

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http://dx.doi.org/10.1016/j.jsams.2020.05.012DOI Listing

Involvement of activin a receptor type 1 (ACVR1) in the pathogenesis of primary focal hyperhidrosis.

Biochem Biophys Res Commun 2020 May 27. Epub 2020 May 27.

Department of Thoracic Surgery, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Gulou District, Fuzhou, People's Republic of China. Electronic address:

The pathogenesis of primary focal hyperhidrosis (PFH) is still not clear. PFH is thought to be a genetic disease. Whether activin A receptor type 1 (ACVR1) is involved in the pathogenesis of PFH is unknown. Read More

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http://dx.doi.org/10.1016/j.bbrc.2020.05.052DOI Listing

Correction to: The impact of endoscopic thoracic sympathectomy on sudomotor function in patients with palmar hyperhidrosis.

Clin Auton Res 2020 May 25. Epub 2020 May 25.

Uemura Pain Clinic, Fukuoka, Japan.

Unfortunately, the 3rd coauthor name has been published incorrectly in the original publication. Read More

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http://dx.doi.org/10.1007/s10286-020-00699-wDOI Listing

A Previously Healthy Adolescent With Acute Psychosis and Severe Hyperhidrosis.

Pediatrics 2020 Jun;145(6)

Stanford University School of Medicine and.

A previously healthy 15-year-old boy presented with 3 months of progressive psychosis, insomnia, back and groin pain, and hyperhidrosis. On examination, the patient was disheveled, agitated, and soaked with sweat, with systolic blood pressure in the 160s and heart rate in the 130s. Aside from occasional auditory and visual hallucinations, his neurologic examination was normal. Read More

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http://dx.doi.org/10.1542/peds.2019-3786DOI Listing

Sudor Anglicus: an epidemic targeting the autonomic nervous system.

Clin Auton Res 2020 May 20. Epub 2020 May 20.

National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Renaissance England witnessed a series of brief epidemics of a rapid and often fatal illness, the predominant feature of which was a disturbance of the autonomic nervous system. Profuse sweating was both an emblematic and ominous sign of this Sudor Anglicus. Its story is medically fascinating as well as historically noteworthy. Read More

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http://dx.doi.org/10.1007/s10286-020-00698-xDOI Listing

Treatment of Secondary Hyperhidrosis of the Intergluteal Cleft with Botulinum Toxin.

PM R 2020 May 15. Epub 2020 May 15.

Long School of Medicine at the University of Texas Health Science Center at San Antonio, San Antonio, Texas.

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http://dx.doi.org/10.1002/pmrj.12404DOI Listing

Sympathetic outflow disturbance following posterior deformity correction: A rare complication.

World Neurosurg 2020 May 11. Epub 2020 May 11.

Department of Spine Services, Indian Spinal Injuries Centre, Vasant kunj, Sector C, New Delhi. Pin: 110070.

Introduction: Sympathetic system injury is a known but rare complication in scoliosis deformity correction. It is not common following posterior correction. We report case of diastematomyelia with neuromuscular scoliosis with unusual complication of sympathetic outflow disturbance, after posterior instrumented correction. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.039DOI Listing

Quality of life after thoracic sympathectomy for palmar hyperhidrosis: a meta-analysis.

Gen Thorac Cardiovasc Surg 2020 May 10. Epub 2020 May 10.

Department of Thoracic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Objective: Palmar hyperhidrosis affects 0.6-10% of the general population, having an important impact in patients' quality of life. The definitive treatment for palmar hyperhidrosis is thoracic sympathectomy. Read More

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http://dx.doi.org/10.1007/s11748-020-01376-5DOI Listing

The Spectrum of Sleep Disorders Among Children: A Cross-sectional Study at a South Indian Tertiary Care Hospital.

Cureus 2020 Apr 4;12(4):e7535. Epub 2020 Apr 4.

Pediatrics, King Fahad Military Medical Complex, Dhahran, SAU.

Introduction Sleep problems during infancy and early childhood are fairly common and rarely recognized in pediatric practice. These are mostly related to the initiation and maintenance of night-time sleep. Understanding sleep patterns and disorders associated with sleep is challenging, especially in the pediatric age group. Read More

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http://dx.doi.org/10.7759/cureus.7535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198097PMC

Anatomic variations of the intrathoracic nerves and the neural connections of the second and third thoracic sympathetic ganglia to the brachial plexus.

Clin Anat 2020 May 5. Epub 2020 May 5.

Department of Anatomy, School of Medicine, Kangwon National University, Chuncheon, South Korea.

Introduction: This study investigated morphological variations of the intrathoracic nerves and the neural connections of the second and third thoracic sympathetic ganglia to the brachial plexus based on the existence of the intrathoracic nerves and the rami communicantes.

Materials And Methods: Fifty thoracic sympathetic trunks from 26 Korean adult cadavers were used.

Results: The first intrathoracic nerve connecting the first and second thoracic nerves was observed on 36 sides (72%), and the second intrathoracic nerve connecting the second and third thoracic nerves was found on 3 sides (6%). Read More

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http://dx.doi.org/10.1002/ca.23619DOI Listing

Ross Syndrome: A Patient with a 23-Year History.

Case Rep Neurol 2020 Jan-Apr;12(1):132-135. Epub 2020 Apr 8.

Department of Neurology, Sjællands Universitetshospital, Roskilde, Denmark.

We present a 60-year-old female with a 23-year history of anhidrosis with concomitant heat intolerance. At examination, we found a right-sided tonic pupil, absent tendon reflexes, and a segmental patch of compensatory hyperhidrosis in the left lower quadrant of her trunk. To further confirm this finding, a minor test (a starch-iodine test, which is used to evaluate the sudomotor function, sweating) was performed. Read More

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http://dx.doi.org/10.1159/000507186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184827PMC

The impact of endoscopic thoracic sympathectomy on sudomotor function in patients with palmar hyperhidrosis.

Clin Auton Res 2020 Apr 27. Epub 2020 Apr 27.

Uemura Pain Clinic, Fukuoka, Japan.

Purpose: When performing endoscopic thoracic sympathectomy (ETS) in palmar hyperhidrosis patients, a device can be used to measure sweat volume pre- and postoperatively in order to assess indications and treatment effects. In this study, we measured changes in the dynamics of sweating in hyperhidrosis patients pre- and postoperatively and compared the values with those in healthy subjects without hyperhidrosis.

Methods: The patient group comprised 25 persons with palmar hyperhidrosis who were scheduled for ETS. Read More

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http://dx.doi.org/10.1007/s10286-020-00685-2DOI Listing

Topical delivery of siRNA into skin using ionic liquids.

J Control Release 2020 Apr 24;323:475-482. Epub 2020 Apr 24.

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, 52 Oxford St, Cambridge, MA 02138, USA. Electronic address:

Skin diseases such as lupus, cancer, psoriasis, and hyperhidrosis can potentially be treated effectively by suppressing allele-specific genes using small interfering RNA (siRNA). Injections of siRNA into skin, though effective, are painful and cover small surface areas and thus are not suitable as a long-term treatment option. Topical delivery of siRNA is an attractive alternative option to mediate RNA interference (RNAi). Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.04.038DOI Listing

Thoracoscopic delivery of therapeutics in the swine sympathetic chain: Implications for future neuromodulation.

J Clin Neurosci 2020 Apr 23. Epub 2020 Apr 23.

Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA.

The thoracic sympathetic chain is implicated in several disease processes including palmar hyperhidrosis and complex regional pain syndrome. These diseases are often medically refractory and require surgical treatments including sympathectomies and ganglion blocks. The use of chemogenetic or optogenetic technologies to modulate sympathetic chain activity may be a potential treatment for these diseases. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.04.099DOI Listing

Correlation between benign joint hypermobility syndrome and primary focal hyperhidrosis in children: a novel concept.

BMC Musculoskelet Disord 2020 Apr 24;21(1):268. Epub 2020 Apr 24.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Benign joint hypermobility syndrome (BJHS) is one of the most common hereditary connective tissue disorders in children in which autonomic nervous system involvement has been reported. This study aimed to evaluate the frequency of primary focal hyperhidrosis in children with BJHS.

Methods: This observational-analytical study was conducted in a case-control setting on children aged 3 to 15 years in 2018 at Mofid Children's Hospital, Tehran, Iran. Read More

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http://dx.doi.org/10.1186/s12891-020-03264-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183110PMC
April 2020
1.898 Impact Factor

Long-term results of the treatment of primary hyperhidrosis with oxybutynin: follow-up of 1,658 cases.

Int J Dermatol 2020 Jun 16;59(6):709-715. Epub 2020 Apr 16.

Department of Vascular and Endovascular Surgery, Hospital Israelita Albert Einstein, Morumbi, São Paulo, Brazil.

Background: Hyperhidrosis (HH) is characterized by exaggerated sweating in a specific region due to hyperfunction of the sweat glands. In the late 2000s, we started treating patients with an anticholinergic, oxybutynin, that was not being used until then.

Objectives: To present, after 12 years of utilizing this medication in our service, the substantial experience obtained with the use of oxybutynin as an initial treatment of HH in a large series of 1,658 patients. Read More

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http://dx.doi.org/10.1111/ijd.14872DOI Listing

Botulinum toxin type A in chronic non-dyshidrotic palmar eczema: A side-by-side comparative study.

J Dermatol 2020 Jun 14;47(6):601-608. Epub 2020 Apr 14.

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

New indications are being reported for intradermal botulinum toxin type A (BTX-A) owing to its anti-inflammatory and antipruritic actions. Its successful use for dyshidrotic hand eczema and lichen simplex has been reported in a few cases, while its utility in dry palmar eczema not associated with hyperhidrosis has not yet been investigated. The aim of this study was the assessment of the additive efficacy and tolerability of BTX-A in chronic dry palmar eczema. Read More

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http://dx.doi.org/10.1111/1346-8138.15344DOI Listing

Ectopic sympathetic ganglia cells of the ventral root of the spinal cord: an anatomical study.

Anat Cell Biol 2020 Mar 19;53(1):15-20. Epub 2020 Feb 19.

Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA, USA.

The sympathetic trunk ganglia contain the cell bodies of neurons. However, some patients who undergo sympathectomy can develop compensatory hyperhidrosis. To evaluate for ectopic pathways, the present anatomical study was performed. Read More

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http://dx.doi.org/10.5115/acb.19.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118253PMC

Sympathotomy for severe compensatory hyperhidrosis in the trunk due to traumatic cervical spinal cord injury.

J Thorac Dis 2020 Mar;12(3):1115-1117

Department of Thoracic and Cardiovascular Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

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http://dx.doi.org/10.21037/jtd.2020.01.62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138997PMC

New sympathicotomy for prevention of severe compensatory hyperhidrosis in patients with primary hyperhidrosis.

J Thorac Dis 2020 Mar;12(3):765-772

Department of Thoracic and Cardiovascular Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Geumo-dong, Uijeongbu, Gyeonggi-do, Republic of Korea.

Background: Primary hyperhidrosis (PH) is characterized by excessive and uncontrollable secretion in the eccrine sweat glands of the craniofacial region, armpits, hands, and feet. Sympathicotomy is the most effective treatment for severe PH; however, compensatory hyperhidrosis (CH) remains the most devastating postoperative complication. The purpose of the present study was to suggest a new sympathicotomy method for PH to prevent severe CH. Read More

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http://dx.doi.org/10.21037/jtd.2019.12.91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138987PMC

Is the result of modified Allen's test still accurate after endoscopic thoracic sympathectomy?

J Thorac Dis 2020 Mar;12(3):696-704

Department of Thoracic Surgery, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.

Background: The radial artery (RA) is increasingly being used for coronary artery bypass grafting (CABG). Endoscopic thoracic sympathectomy (ETS) has been shown to block innervation of sympathetic nerves of upper limbs, which reduces sweating of hands and dilates blood vessels. The modified Allen's test (MAT) is one of the commonest methods of assessing collateral arm flow prior to RA harvest, though it has limitations. Read More

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http://dx.doi.org/10.21037/jtd.2019.12.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139016PMC

Frey's Syndrome.

N Engl J Med 2020 Apr;382(15):1456

Addenbrooke's Hospital, Cambridge, United Kingdom

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http://dx.doi.org/10.1056/NEJMicm1809117DOI Listing

Robotic Staged Bilateral Selective Postganglionic Sympathectomy for Upper-Extremity Hyperhidrosis.

Surg Technol Int 2020 May;36:265-269

Center for Advanced Thoracic Surgery, Global Robotics Institute, Advent Health, University of Central Florida, Celebration, FL.

Purpose: The prevalence of compensatory hyperhidrosis (CH) has been reported to be as high as 80% in patients following thoracic sympathectomy for upper-extremity hyperhidrosis. The CH rate is 7.2% with simultaneous bilateral robotic selective dorsal sympathectomy. Read More

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Compound Phenotype Due to Recessive Variants in and Genes Disclosed by an Integrated Approach of SNP-Array and Whole Exome Sequencing.

Genes (Basel) 2020 Mar 31;11(4). Epub 2020 Mar 31.

Division of Medical Genetics, Fondazione IRCCS-Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo (Foggia), Italy.

Neurodevelopmental disorders are a challenge in medical genetics due to genetic heterogeneity and complex genotype-phenotype correlations. For this reason, the resolution of single cases not belonging to well-defined syndromes often requires an integrated approach of multiple whole-genome technologies. Such an approach has also unexpectedly revealed a complex molecular basis in an increasing number of patients, for whom the original suspect of a pleiotropic syndrome has been resolved as the summation effect of multiple genes. Read More

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http://dx.doi.org/10.3390/genes11040379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230222PMC

Sleep disturbances in Italian children and adolescents with epilepsy: A questionnaire study.

Epilepsy Behav 2020 May 28;106:107014. Epub 2020 Mar 28.

Epilepsy Center - Sleep Medicine Center, Childhood and Adolescence Neuropsychiatry Unit, ASST SS. Paolo e Carlo, San Paolo Hospital, Milan, Italy; Department of Health Sciences, University of Milan, Italy.

Sleep and epilepsy interact with each other in a complex bidirectional way. The main objective of this study was to characterize and determine the prevalence of sleep and behavioral disorders among Italian children and adolescents with epilepsy. We asked 84 consecutive parents/caregivers of patients with epilepsy aged between 6 and 17 years old to fill out the Sleep Disturbances Scale for Children (SDSC) and Child Behavior Checklist (CBCL). Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107014DOI Listing

[Recurrent episodes of hypothermia as a sequela of human herpesvirus 6 encephalitis following cord blood transplantation for acute myeloid leukemia].

Rinsho Ketsueki 2020 ;61(3):274-279

Department of Hematology, Toranomon Hospital Kajigaya.

A 46-year-old female patient underwent a cord blood transplantation (conditioning regimen: fludarabine/busulfan4/melphalan80; graft-versus-host disease (GVHD) prophylaxis: tacrolimus + mycophenolate mofetil) for acute myeloid leukemia (AML) with her 1st hematological complete response to induction therapy (idarubicin 3 days+cytarabine 7 days). She lost her consciousness due to human herpesvirus 6 (HHV-6) encephalitis on day 31, and therefore, we increased the foscarnet dosage (from 120 mg/kg to 180 mg/kg). Her consciousness level improved after treatment. Read More

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http://dx.doi.org/10.11406/rinketsu.61.274DOI Listing

Microsurgical robotic suturing of sural nerve graft for sympathetic nerve reconstruction: a technical feasibility study.

J Thorac Dis 2020 Feb;12(2):97-104

Division of Thoracic Surgery, Chang Gung Memorial Hospital-Linko, Chang Gung University, Taoyuan.

Background: Endoscopic thoracic sympathectomy (ETS) may provide a permanent surgical cure for primary palmar hyperhidrosis. Unfortunately, some patients can experience intensive post-operative compensatory sweating (CS) that ultimately impairs quality of life. Sympathetic nerve reconstruction (SNR) may be used to counteract severe post-operative CS through the restoration of sympathetic pathways. Read More

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http://dx.doi.org/10.21037/jtd.2019.08.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061194PMC
February 2020

Microwave Thermolysis Reduces Generalized and Social Anxiety in Young Adults With Axillary Hyperhidrosis.

Lasers Surg Med 2020 Mar 16. Epub 2020 Mar 16.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, Maryland, 21287.

Background And Objective: Hyperhidrosis (HH) is associated with impairments in quality of life (QOL) and elevated anxiety. Microwave thermolysis is a newer treatment that reduces sweating, yet effects on QOL and emotional symptoms have not been examined. Two treatment sessions are recommended to achieve 80% amelioration of clinical HH. Read More

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http://dx.doi.org/10.1002/lsm.23229DOI Listing

Complex regional pain syndrome: A case report and review of the literature.

Ann Afr Med 2020 Jan-Mar;19(1):68-70

Department of Orthopedics, King Saud Bin Abdulaziz University, Riyadh, Saudi Arabia.

Background: Complex regional pain syndrome (CRPS) is a rare neuropathic pain disorder associated with severe pain, muscle weakness, limb edema and hyperhidrosis. Predisposing factors include fracture, surgery, stroke and spinal cord injury. CRPS may recur in the same limb or spread to other limbs to complicate management. Read More

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http://dx.doi.org/10.4103/aam.aam_23_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189882PMC

Long-term efficacy and safety of topical glycopyrronium tosylate for the treatment of primary axillary hyperhidrosis: Post hoc pediatric subgroup analysis from a 44-week open-label extension study.

Pediatr Dermatol 2020 Mar 8. Epub 2020 Mar 8.

Eastern Virginia Medical School, Virginia Clinical Research, Inc., Norfolk, Virginia, United States.

Background/objectives: Glycopyrronium tosylate (GT) cloth, 2.4% is a topical anticholinergic approved in the United States for primary axillary hyperhidrosis in patients ≥9 years. This post hoc analysis evaluated long-term response (efficacy and safety) in pediatric patients (≥9 to ≤16 years) to GT in the 44-week, open-label extension (NCT02553798) of two, phase 3, double-blind, vehicle-controlled, 4-week trials (NCT02530281, NCT02530294). Read More

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http://dx.doi.org/10.1111/pde.14135DOI Listing

Rapid, Large, and Synchronous Sweat and Cardiovascular Responses Upon Minor Stimuli in Healthy Subjects. Dynamics and Reproducibility.

Front Neurol 2020 4;11:51. Epub 2020 Feb 4.

Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

The aim of the study was to investigate steady state levels, dynamics and reproducibility of cardiovascular variables and electrodermal activity in different skin areas in response to minor physiological and mental stimuli in healthy subjects in the thermoneutral zone, carried out in high time resolution. Thirteen healthy subjects underwent experiments on two separate days. Non-invasive electrodermal activity in five different skin areas was measured continuously using a skin conductance method, including resting supine and sitting positions, performing deep inspirations, a mental challenge and being exposed to a sudden loud sound. Read More

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http://dx.doi.org/10.3389/fneur.2020.00051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010925PMC
February 2020

[Development and clinical success of novel soft drugs].

Authors:
Miklós Bodor

Orv Hetil 2020 Mar;161(10):363-373

University of Florida Gainesville, FL, Amerikai Egyesült Államok.

Retrometabolic drug design combines the structure-activity and structure-metabolism relationships, allowing the effective separation of drug action and side effects. This combination results in significant improvement of the therapeutic index. The main aim is not only to study the metabolism but to build into the drug molecule the desired metabolic route, in addition to the therapeutic activity. Read More

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http://dx.doi.org/10.1556/650.2020.31657DOI Listing

Analysis of the Epidemiological, Clinical Characteristics, Treatment and Prognosis of Human Brucellosis During 2014-2018 in Huludao, China.

Infect Drug Resist 2020 11;13:435-445. Epub 2020 Feb 11.

Department of Epidemiology, School of Public Health, China Medical University, Shenyang, Liaoning, People's Republic of China.

Purpose: To describe the incidence trend, demographic and clinical characteristics, treatment and prognosis, epidemiological history and risk factors of human brucellosis in Huludao, China.

Patients And Methods: A total of 1887 brucellosis patients were reported in Huludao, China from January, 2014 to December, 2018 and the case questionnaires from 1149 patients were collected from Huludao Municipal Center for Disease Control and Prevention. Demographic characteristics of the patients and the information relating to the patients' clinical manifestations, diagnosis, treatment and prognosis were collected and analyzed. Read More

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http://dx.doi.org/10.2147/IDR.S236326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023865PMC
February 2020

Risk factors and clinical features of paroxysmal sympathetic hyperactivity after spontaneous intracerebral hemorrhage.

Auton Neurosci 2020 Jan 27;225:102643. Epub 2020 Jan 27.

Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, China. Electronic address:

Background And Purpose: Paroxysmal sympathetic hyperactivity (PSH) is a rare complication of spontaneous intracerebral hemorrhage (ICH).We aimed to evaluate the risk factors and clinical features for PSH after ICH.

Methods: From January 1, 2013 to April 1, 2018, patients with ICH were consecutively included in this observational study. Read More

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http://dx.doi.org/10.1016/j.autneu.2020.102643DOI Listing
January 2020

Onabotulinum Toxin A for Sacral and Intergluteal Cleft Hyperhidrosis.

JAMA Dermatol 2020 Feb 19. Epub 2020 Feb 19.

Department of Dermatology, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1001/jamadermatol.2019.4757DOI Listing
February 2020

A questionnaire study on sleep disturbances associated with Prader-Willi syndrome.

J Pediatr Endocrinol Metab 2020 Mar;33(3):397-401

Pediatric, Universidade de São Paulo Instituto da Criança, São Paulo, Brazil.

Background This study aimed to investigate the presence of sleep disturbances in children with Prader-Willi syndrome (PWS) using the Sleep Disturbance Scale for Children (SDSC). Methods The SDSC, which was designed to identify the presence and severity of different sleep disorders, was applied to 50 patients with PWS and 112 controls. Results Patients with PWS achieved worse scores in the sleep-disordered breathing and disorders in initiating and maintaining sleep in the SDSC questionnaire as compared with controls. Read More

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http://dx.doi.org/10.1515/jpem-2019-0489DOI Listing
March 2020
0.711 Impact Factor

Efficacy and safety of topical sofpironium bromide gel for the treatment of axillary hyperhidrosis: A phase II, randomized, controlled, double-blinded trial.

J Am Acad Dermatol 2020 Jun 15;82(6):1321-1327. Epub 2020 Feb 15.

Brickell Biotech, Inc, Boulder, Colorado.

Background: Primary axillary hyperhidrosis has limited noninvasive, effective, and well-tolerated treatment options.

Objective: To evaluate the topical treatment of axillary hyperhidrosis with the novel anticholinergic sofpironium bromide.

Methods: A phase II, multicenter, randomized, controlled, double-blinded study. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.02.016DOI Listing

Personality traits associated with blepharospasm: A comparison with healthy subjects, patients with facial hemispasm and patients with hyperhidrosis.

J Clin Neurosci 2020 Apr 15;74:130-134. Epub 2020 Feb 15.

Department of Neuroscience, Reproductive Science and Dentistry, Federico II University of Naples, Naples, Italy.

The aim of this study is to explore the existence of specific personality traits related to patients with blepharospasm (BSP), treated with injections of botulinum neurotoxin (BTX). Sixteen patients with BSP, 22 with facial hemispasm (HFS), 20 with essential hyperhidrosis (EH) and 20 healthy controls (HCs) completed the Temperament and Character Inventory-Revised to explore personality traits based on Cloninger's Psychobiological Model. The results revealed that the four groups differed on the Harm Avoidance (HA) scale and fear of uncertainty subscale, as well as on Persistence (PS). Read More

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http://dx.doi.org/10.1016/j.jocn.2020.02.018DOI Listing

Comparative analysis of the results of videothoracoscopic sympathectomy in the treatment of hyperhidrosis in adolescent patients.

J Pediatr Surg 2020 Mar 23;55(3):418-424. Epub 2020 Jan 23.

Department of Vascular and Endovascular Surgery, Hospital Israelita Albert Einstein.

Objective: Several factors that could influence the efficacy and satisfaction of patients after bilateral thoracic sympathectomy (VATS) in the treatment of hyperhidrosis (HH) have been studied, but no studies in the literature have specifically analyzed the effectiveness of treatment and variations in the quality of life of adolescents patients compared to those of adult patients (18-40 years).

Methods: We retrospectively analyzed 2431 hyperhidrosis patients who underwent bilateral VATS and divided the patients into the following groups: adolescents (472 patients) and adult group (1760 patients). Variables included quality of life prior to surgery, improvement in quality of life after surgery, clinical improvement in sweating, presence of severe compensatory hyperhidrosis and general satisfaction at one month after surgery. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.11.004DOI Listing

The safety and feasibility of intraoperative near-infrared fluorescence imaging with indocyanine green in thoracoscopic sympathectomy for primary palmar hyperhidrosis.

Thorac Cancer 2020 Apr 15;11(4):943-949. Epub 2020 Feb 15.

Department of Thoracic Surgery, Beijing Haidian Hospital (Haidian Section of Peking University Third Hospital), Beijing, China.

Background: We investigated the safety and feasibility of intraoperative near-infrared (NIR) imaging using indocyanine green (ICG) during sympathectomy in the management of primary palmar hyperhidrosis (PPH).

Methods: We performed a retrospective review of 142 patients (ICG group) who underwent endoscopic thoracic sympathectomy (ETS) between February 2018 and April 2019. All patients received a 5 mg/kg infusion of ICG 24 hours preoperatively. Read More

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http://dx.doi.org/10.1111/1759-7714.13345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113049PMC
April 2020
1.126 Impact Factor

Unilateral hyperhidrosis secondary to brainstem meningioma producing mass effect.

Dermatol Online J 2019 Nov 15;25(11). Epub 2019 Nov 15.

University of Louisville School of Medicine, Louisville, KY.

Unilateral hyperhidrosis of neurological origin has been associated with head trauma, cerebral palsy, spinal cord injury, peripheral neuropathy, lesions of the hypothalamus, and cerebral or brainstem strokes. In this report, we describe a 61-year-old man with isolated sweating on the left side of his entire body. A right-sided brainstem meningioma producing mass effect is suspected as the underlying etiology. Read More

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November 2019

[Clinical application of midpiece facial nerve dissection in regional parotidectomy].

Hua Xi Kou Qiang Yi Xue Za Zhi 2020 Feb;38(1):37-41

Dept. of Oral and Maxillofacial Surgery, The General Hospital of Western Theater Command, Chengdu 610021, China.

Objective: To propose and evaluate the clinical effect of midpiece facial nerve dissection through transparotid approach in regional parotidectomy.

Methods: A total of 136 patients with benign parotid tumors were categorized into three groups according to the way of facial nerve dissection: anterograde dissection from main trunk (anterograde, n=70), retrograde dissection from distal branches (retrograde, n=34), and midpiece dissection through transparotid approach (middle dissection, n=32). Surgery duration, facial nerve injury, salivary fistula, earlobe sensation, Frey's syndrome, and aesthetic evaluation were compared. Read More

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http://dx.doi.org/10.7518/hxkq.2020.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184311PMC
February 2020

Neurokinin-1 antagonist orvepitant for EGFRI-induced pruritus in patients with cancer: a randomised, placebo-controlled phase II trial.

BMJ Open 2020 Feb 6;10(2):e030114. Epub 2020 Feb 6.

Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.

Objective: To evaluate the efficacy of orvepitant (10 or 30 mg given once daily, orally for 4 weeks), a neurokinin-1 receptor antagonist, compared with placebo in reducing the intensity of epidermal growth factor receptor inhibitor (EGFRI)-induced intense pruritus.

Design: Randomised, double-blind, placebo-controlled clinical trial.

Setting: 15 hospitals in Italy and five hospitals in the UK. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-030114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045265PMC
February 2020

Contralateral hyperhidrosis following lateral medullary infarction.

Pract Neurol 2020 Jan 30. Epub 2020 Jan 30.

Department of Neurology, Monash Health, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1136/practneurol-2019-002346DOI Listing
January 2020

Sweating Disorders.

Continuum (Minneap Minn) 2020 Feb;26(1):116-137

Purpose Of Review: This article reviews disorders of sweating, including hyperhidrosis and anhidrosis due to central or peripheral autonomic nervous system causes.

Recent Findings: Disorders of thermoregulation and sweating may manifest with hyperhidrosis or hypohidrosis/anhidrosis. Primary disorders of hyperhidrosis may significantly impact quality of life yet tend to be benign. Read More

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http://dx.doi.org/10.1212/CON.0000000000000813DOI Listing
February 2020

Physiology and Pathophysiology of the Autonomic Nervous System.

Continuum (Minneap Minn) 2020 Feb;26(1):12-24

Purpose Of The Review: This article reviews the anatomic, functional, and neurochemical organization of the sympathetic and parasympathetic outputs; the effects on target organs; the central mechanisms controlling autonomic function; and the pathophysiologic basis for core symptoms of autonomic failure.

Recent Findings: Functional neuroimaging studies have elucidated the areas involved in central control of autonomic function in humans. Optogenetic and other novel approaches in animal experiments have provided new insights into the role of these areas in autonomic control across behavioral states, including stress and the sleep-wake cycle. Read More

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http://dx.doi.org/10.1212/CON.0000000000000817DOI Listing
February 2020

Ultrasound-guided median and ulnar nerve blocks in the forearm to facilitate onabotulinum toxin A injection for palmar hyperhidrosis.

J Am Acad Dermatol 2020 Jan 25. Epub 2020 Jan 25.

Breakthru Acute Pain & Ketamine Clinic, Tampa, Florida.

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http://dx.doi.org/10.1016/j.jaad.2020.01.033DOI Listing
January 2020

Significant cardiac disease complicating Graves' disease in previously healthy young adults.

Endocrinol Diabetes Metab Case Rep 2020 Jan 22;2020. Epub 2020 Jan 22.

Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Heath Park, Cardiff, UK.

Summary: Graves' disease is associated with tachydysrythmia, cardiac ischaemia and cardiomyopathy - all uncommon in young adults without previous cardiac disease. We present three young individuals who developed cardiac complications after periods of uncontrolled Graves' disease. Subject 1: A 34-year-old female had severe thyrotoxic symptoms for weeks. Read More

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http://dx.doi.org/10.1530/EDM-19-0132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993248PMC
January 2020