4,988 results match your criteria Hyperhidrosis


Harlequin syndrome.

J Eur Acad Dermatol Venereol 2021 May 11. Epub 2021 May 11.

Dermatology Hospital, Southern Medical University, Guangzhou, China.

An 8-year-old girl presented to our dermatology clinic with a 4-year history of paroxysmal flushing and hyperhidrosis on the left side of her face, neck, upper limb, and upper chest induced by heat, exercise, and spicy food. However, the opposite side remains pale and anhidrotic. The skin disorder could be reproduced after a stress test involving 20 min of exercising (Figure). Read More

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Comparison of EQ-5D-3L and metabolic components between patients with hyperhidrosis and the general population: a propensity score matching analysis.

Qual Life Res 2021 May 11. Epub 2021 May 11.

Department of Family Medicine, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, Korea.

Purpose: It is important to understand the characteristics of patients with hyperhidrosis, which are different from the general population, for treating hyperhidrosis. Sympathetic overactivity, which might play an important role in hyperhidrosis, can contribute to metabolic diseases and the decreased quality of life (QoL). We compared the metabolic components and health-related QoL between patients with hyperhidrosis and the general population. Read More

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Factors responsible for difficult to treat superficial fungal infections: A study from a tertiary healthcare center in India.

Mycoses 2021 May 9. Epub 2021 May 9.

Department of Dermatology, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, India, 411 043.

Background: Recurrent and clinically unresponsive dermatophytosis is being increasingly observed in India. However, there is little information regarding the extent of the problem and the factors responsible for these difficult to treat superficial fungal infections.

Aim: To identify factors contributing to difficult to treat recurrent superficial fungal infections. Read More

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Hairless Hyperhidrotic Plaque in a Young Male.

Indian Dermatol Online J 2021 Mar-Apr;12(2):368-370. Epub 2021 Feb 22.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

An 18-year-old male presented with an erythematous plaque on the left side of face and neck since 4 years. The lesion was devoid of hair, had follicular prominences, and showed increased localized sweating. Histopathology revealed an increased number of eccrine glands in the myxoid stroma with multiple vascular elements in the dermis, favoring the diagnosis of eccrine angiomatous hamartoma. Read More

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February 2021

Morvan syndrome associated with LGI1 antibody: a case report.

BMC Neurol 2021 May 3;21(1):185. Epub 2021 May 3.

Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.

Background: Morvan syndrome (MoS) is a rare autoimmune syndrome associated with antibodies against two kinds of potassium channel proteins, contactin associated protein-like 2 (CASPR2) and leucine-rich glioma inactivated protein 1 (LGI1). MoS patients with only LGI1-antibody seropositivity have rarely been reported. Here, we describe a 64-year-old male MoS patient with only LGI1-antibody seropositivity. Read More

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Management of Primary Focal Hyperhidrosis: An Algorithmic Approach.

J Drugs Dermatol 2021 May;20(5):523-528

Hyperhidrosis (HH) is defined as perspiration beyond the level required to maintain temperature regulation. HH affects nearly 4.8% of the population in the United States. Read More

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Paroxysmal localized Hyperhidrosis, a case-report: When excessive sweating occurs in combination with severe headaches.

Cephalalgia 2021 May 2:3331024211006843. Epub 2021 May 2.

Department of Neurology and Clinical Neurophysiology, Albert Schweitzer Hospital, Dordrecht, the Netherlands.

Background: Paroxysmal localized hyperhidrosis is a rare disorder of the central autonomic nervous system. No association between paroxysmal hyperhidrosis and severe headache has been previously described in literature. A 65-year-old woman with idiopathic paroxysmal localized hyperhidrosis combined with severe holocranial headache attacks is described in this case report. Read More

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[Spontaneous periodic hypothermia syndrome: A systematic review of the literature].

Rev Med Interne 2021 Apr 28. Epub 2021 Apr 28.

Service de médecine interne, CHU de Saint-Étienne, 42055 Saint-Étienne cedex, France.

Introduction: Periodic spontaneous hypothermia syndrome (PSHS), also known as hypersudation-hypothermia syndrome, is a rare condition characterised by the occurrence of paroxysmal attacks of spontaneous hypothermia occurring without age limit. Few studies have attempted to synthesise the available data on PSHS. The objective of this study was to summarize the literature on this condition. Read More

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Increased Incidence of Premenstrual Syndrome in Females with Palmar Hyperhidrosis.

Int J Environ Res Public Health 2021 Apr 28;18(9). Epub 2021 Apr 28.

Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.

Background: Premenstrual syndrome (PMS) is a common disorder affecting the quality of life of women of reproductive age. In a previous study, sex hormone imbalances and alterations in autonomic function were present in PMS, with parasympathetic dysfunction and sympathetic overactivity during the late luteal phase. Palmar hyperhidrosis (PH) presents with oversweating, heat and emotional stimulation, sympathetic hyperactivity and parasympathetic hypofunction. Read More

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How We Do It: Image-Guided Microwave-Based Therapy for Axillary Hyperhidrosis and Osmidrosis.

Dermatol Surg 2021 May;47(5):738-739

Department of Dermatology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.

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Episodic headache with spontaneous hypothermia reveal Shapiro's syndrome variant with effectiveness of clonidine therapy.

J Headache Pain 2021 Apr 26;22(1):30. Epub 2021 Apr 26.

Department of Neurology and Center of Expertise in Parkinson's disease, University Hospital of Amiens, CHU Amiens-Picardie, 80 054 Cedex 1, Amiens, France.

Background: Episodic headache with spontaneous hypothermia constitute an uncommon association and is not well recognized in the International Classification of Headache Disorders (ICHD-3). Spontaneous periodic hypothermia, also called Shapiro's syndrome, is a rare disease characterized by hypothermia attacks associated or not with hyperhidrosis without any triggering factor.

Case Presentation: We report a rare case of Shapiro's syndrome variantrevealed by episodes of headache with spontaneous hypothermia witheffectiveness of clonidine therapy in a 76-year-old Parkinson's disease woman. Read More

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Moisture Response Films Versus the Starch Iodine Test for the Detection of Palmar Hyperhidrosis.

Dermatol Surg 2021 May;47(5):668-671

Department of Dermatology and Venereology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

Background: The starch iodine test (SIT) is the gold-standard diagnostic tool for primary palmar hyperhidrosis (PPH).

Objective: This study aimed to evaluate the clinical effectiveness and safety profile of a novel approach for the detection of PPH by moisture response films (MRF) in comparison to the SIT.

Methods: This prospective comparative study of the 2 tests was conducted on 17 patients with PPH. Read More

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Treatment of primary axillary hyperhidrosis with a cream formulation of oxybutynin chloride 10.

J Eur Acad Dermatol Venereol 2021 Apr 23. Epub 2021 Apr 23.

Faculty of Medicine, 1st Department of Dermatology-Venereology, Andreas Sygros Hospital, National and Kapodistrian University of Athens, Athens, Greece.

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Thoracoscopic bilateral dorsal sympathectomy for primary palmo-axillary hyperhidrosis short- and mid-term results.

J Minim Access Surg 2021 Apr 8. Epub 2021 Apr 8.

Centre For Chest Surgery, Sir Ganga Ram Hospital, New Delhi, India.

Background: Thoracoscopic bilateral dorsal sympathectomy is the standard of care for primary palmo-axillary hyperhidrosis. This study aims at studying the surgical outcomes with special emphasis on the incidence of compensatory hyperhidrosis (CH) after thoracoscopic dorsal sympathectomy. Post-procedural patient satisfaction as well as quality of life was measured and analysed. Read More

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Commentary on Fractional CO2 Laser for Transcutaneous Drug Delivery of Onabotulinum Toxin in Palmar Hyperhidrosis.

Dermatol Surg 2021 May;47(5):684

Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California.

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Autonomic dysfunction following COVID-19 infection: an early experience.

Clin Auton Res 2021 Apr 16. Epub 2021 Apr 16.

Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Purpose: Post-COVID-19 syndrome is a poorly understood aspect of the current pandemic, with clinical features that overlap with symptoms of autonomic/small fiber dysfunction. An early systematic analysis of autonomic dysfunction following COVID-19 is lacking and may provide initial insights into the spectrum of this condition.

Methods: We conducted a retrospective review of all patients with confirmed history of COVID-19 infection referred for autonomic testing for symptoms concerning for para-/postinfectious autonomic dysfunction at Mayo Clinic Rochester or Jacksonville between March 2020 and January 2021. Read More

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CT-guided thoracic sympathicolysis versus VATS sympathectomy in the therapeutic concept for severe primary palmar Hyperhidrosis.

Thorac Cardiovasc Surg 2021 Apr 15. Epub 2021 Apr 15.

Institute of Diagnostic and Interventional Radiology/Neuroradiology, Westkuestenklinikum Heide, Academic Teaching Hospital of the Universities of Kiel, Luebeck and Hamburg, Heide, Germany.

Background:  The objective was to compare computed tomography (CT)-guided thoracic sympathicolysis (CTSy) and video-assisted thoracoscopic sympathectomy (VATS) with regard to their feasibility, the occurrence of minor and major complications, and the clinical outcome.

Materials And Methods:  In this study, 88 patients treated by CTSy and 86 patients treated by VATS were retrospectively included. CTSy was performed after establishing the entry plane below the level of the intervertebral space T2/3 via a dorsolateral approach using a 22-G coaxial needle. Read More

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Isoniazid induced palmoplantar hyperhidrosis.

Trop Doct 2021 Apr 15:494755211007966. Epub 2021 Apr 15.

Assitant professor, Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, India.

Secondary focal hyperhidrosis is usually due to peripheral or central neuronal defects and is a complex dysfunction of the parasympathetic and sympathetic nervous system. Palmoplantar hyperhidrosis has been described with various types of polyneuropathies such as diabetic but has not previously been described with isoniazid. We report a 15-year-old boy, being followed for neurotuberculosis, who presented with burning sensation and hyperhidrosis of both palms and soles five months after starting antitubercular therapy. Read More

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Hyperhidrosis Disease Severity Measure-Axillary (HDSM-Ax): Evaluation of Measurement Performance.

J Drugs Dermatol 2021 Apr;20(4):410-418

Background: Clinical trials of primary axillary hyperhidrosis (AHH) require rigorous measurement of AHH severity from the patient’s perspective. Previously, we reported conceptualization and item content development for the Hyperhidrosis Disease Severity Measure-Axillary (HDSM-Ax) scale.

Objective: To evaluate the psychometric performance and estimate clinically meaningful change scores for the HDSM-Ax in a Phase IIb clinical study of sofpironium bromide gel for AHH. Read More

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Traditional Korean medicine treatment for tamoxifen associated adverse events of breast cancer patient: A CARE - Compliant case report.

Complement Ther Clin Pract 2021 May 2;43:101378. Epub 2021 Apr 2.

Chung-Yeon Central Institute, 64, Sangmujungang-ro, Seo-gu, Gwangju, 61949, Republic of Korea. Electronic address:

Background: Adverse events of endocrine therapy reduce the breast cancer patient's quality of life and adversely affect treatment compliance.

Method: A 50-year-old breast cancer patient complained of several symptoms such as hot flush, hyperhidrosis, urinary frequency, and depression. These symptoms occurred after taking tamoxifen. Read More

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THORACIC SYMPATHECTOMY: SEDATION EXPERIENCE.

Rev Port Cir Cardiotorac Vasc 2021 Apr 8;28(1):31-33. Epub 2021 Apr 8.

Cardiothoracic Surgery, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal.

Introduction/Study Goals: Thoracic sympathectomy is considered to be the most effective treatment for hyperhidrosis, a procedure traditionally performed under general anesthesia. Nowadays it's a minimally invasive procedure, which makes it possible to perform under sedation with local anesthesia. The goal in this study was to assess the efficacy and safety of this anesthetic technique in video-assisted thoracic sympathectomy. Read More

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Dermatological diseases in seamen's lower extremity: a prevalence study.

Int Marit Health 2021 ;72(1):18-25

University of A Coruña, A Coruña, Spain.

Background: Little is known about the impact of occupational seafaring on lower limb conditions. The aim of the study was to estimate the prevalence of dermatological diseases affecting the feet and lower extremities of seafarers, as well as the possible impact of working conditions on the development of the pathologies analysed.

Materials And Methods: A prevalence study was performed through self-completed questionnaires at the "Instituto Social de la Marina" (ISM) centres at A Coruña, Ribeira, Noya and Cádiz (Spain). Read More

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January 2021

The inflatable carrot-An orthosis for fingertip wound healing in flexion contractures of the hand: A case report.

J Hand Ther 2021 Jan 15. Epub 2021 Jan 15.

Department of Burns & Plastic Surgery, Royal Preston Hospital, Lancashire Teaching Hospitals, Preston, UK.

Study Design: Case report.

Introduction: Severe flexure contractures of the hand secondary to upper limb spasticity (ULS) cause pain, palmar hyperhidrosis, ulceration, and nail plate deformities. Nonoperative management includes traditional orthotic devices that can be very painful for severe contractures and Botox injections, which provide a temporary solution. Read More

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January 2021

Clinical presentation and autonomic profile in Ross syndrome.

J Neurol 2021 Apr 3. Epub 2021 Apr 3.

Department of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA.

Background: Ross syndrome is a rare disorder characterized by tonic pupils, hyporeflexia, and segmental anhidrosis. We sought to characterize the clinical presentation, associated autoimmune disorders, and autonomic profile in patients with Ross syndrome to further elucidate its pathophysiology.

Methods: We performed a retrospective chart review of all patients who underwent a thermoregulatory sweat test (TST) between 1998 and 2020 and had confirmation of the diagnosis of Ross syndrome by an autonomic disorders specialist. Read More

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Therapeutic Applications of Botulinum Neurotoxin for Autonomic Symptoms in Parkinson's Disease: An Updated Review.

Toxins (Basel) 2021 03 19;13(3). Epub 2021 Mar 19.

Department of Neurology, Michigan State University, East Lansing, MI 48824-7015, USA.

Parkinson's disease is the most common age-related motoric neurodegenerative disease. In addition to the cardinal motor symptoms of tremor, rigidity, bradykinesia, and postural instability, there are numerous non-motor symptoms as well. Among the non-motor symptoms, autonomic nervous system dysfunction is common. Read More

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Role of Bradykinin Type 2 Receptors in Human Sweat Secretion: Translational Evidence Does Not Support a Functional Relationship.

Skin Pharmacol Physiol 2021 1;34(3):162-166. Epub 2021 Apr 1.

Division of Biomedical Sciences, Marian University College of Osteopathic Medicine, Indianapolis, Indiana, USA.

Bradykinin increases skin blood flow via a cGMP mechanism but its role in sweating in vivo is unclear. There is a current need to translate cell culture and nonhuman paw pad studies into in vivo human preparations to test for therapeutic viability for disorders affecting sweat glands. Protocol 1: physiological sweating was induced in 10 healthy subjects via perfusing warm (46-48°C) water through a tube-lined suit while bradykinin type 2 receptor (B2R) antagonist (HOE-140; 40 μM) and only the vehicle (lactated Ringer's) were perfused intradermally via microdialysis. Read More

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Data on the pharmacokinetic profile of the 1% glycopyrronium bromide cream for a time period beyond 2 weeks are important: Reply from authors.

Br J Dermatol 2021 Apr 1. Epub 2021 Apr 1.

Dr. August Wolff GmbH & Co. KG Arzneimittel, Bielefeld, Germany.

Gregoriou et al ask for systemic PK data beyond 2 weeks following the topical application of glycopyrronium bromide (GPB) containing cream for treatment of primary axillary hyperhidrosis referring to another recently approved glycopyrronium tosylate (GPT) containing topical product. Read More

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Data on the pharmacokinetic profile of the 1% glycopyrronium bromide cream for a time period beyond 2 weeks are important.

Br J Dermatol 2021 Apr 1. Epub 2021 Apr 1.

National and Kapodistrian University of Athens, Faculty of Medicine, Department of Pharmacology.

Abels et al. reported the results of a Phase IIIa randomized placebo-controlled study assessing the efficacy and safety of a formulation of 1% glycopyrronium bromide (GPB) cream applied for 4 weeks as a topical treatment of primary axillary hyperhidrosis . In the preceding phase Ib trial, three concentrations of 0,5%, 1% and 2% GPB cream were applied topically for 2 weeks. Read More

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Effect of botulinum toxin in stellate ganglion for craniofacial hyperhidrosis: a case report.

J Int Med Res 2021 Mar;49(3):3000605211004213

Department of Anesthesiology and Pain Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.

Craniofacial hyperhidrosis causes sweating of the face and scalp due to excessive action of the sweat glands and manifests when patients become tense/nervous or develop an elevated body temperature. If noninvasive treatments are ineffective, invasive treatments such as a sympathetic block and resection are considered. A 32-year-old woman with no specific medical history was referred for uncontrolled craniofacial hyperhidrosis that included excessive sweating and hot flushing. Read More

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