4,538 results match your criteria Hyperhidrosis


[Occupational characteristics and clinical manifestations of 245 cases of occupational brucellosis].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):755-758

HulunBuir People's Hospital, Department of Brucellosis, HulunBuir Clinical Medical College, Inner Mongolia University for Nationalitie, HulunBuir 021008, China.

To analyse epidemiological, clinical characteristics and laboratory examination results of 245 occupational brucellosis form 2008 to 2018, which providing theoretical basis for prevention and control of occupational brucellosis. Based on the China Center for Disease Control and Prevention Information System, a database of occupational brucellosis cases in HunlunBuir from January 2008 to July 2018 was established. The Epidemiological characteristics, Clinical manifestation, laboratory examination of 245 occupational brucellosis and 359 without occupational brucellosis were comparatively analyzed about the same period. Read More

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October 2018

Lithium Treatment Is Safe in Children With Intellectual Disability.

Front Mol Neurosci 2018 22;11:425. Epub 2018 Nov 22.

Henan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Lithium is a widely used and effective treatment for individuals with psycho-neurological disorders, and it exhibits protective and regenerative properties in multiple brain injury animal models, but the clinical experience in young children is limited due to potential toxicity. As an interim analysis, this paper reports the safety/tolerability profiles of low-dose lithium treatment in children with intellectual disability (ID) and its possible beneficial effects. In a randomized, single-center clinical trial, 124 children with ID were given either oral lithium carbonate 6 mg/kg twice per day or the same dose of calcium carbonate as a placebo ( = 62/group) for 3 months. Read More

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November 2018

Short-Term Clinical Outcomes and Safety Associated With Percutaneous Radiofrequency Treatment for Excessive Sweating.

Aesthet Surg J 2018 Dec 9. Epub 2018 Dec 9.

Plastic surgeon in private practice in Osaka City, Japan.

Background: Primary excessive sweating of the axilla affects approximately 3.12% of the US population and has a negative impact on individuals' lives.

Objectives: We report the safety and effectiveness up to 90 days after treating excessive sweating with percutaneous radiofrequency when using a standardized protocol. Read More

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December 2018

A Pocket-Friendly and Sustainable Iontophoresis Apparatus for Palmoplantar Hyperhidrosis: Advancement over a Previously Described Homemade Design.

J Cutan Aesthet Surg 2018 Jul-Sep;11(3):153-156

Department of Dermatology, People's College of Medical Sciences and Research Centre, People's University, Bhopal, Madhya Pradesh, India.

Introduction And Objectives: Tap water iontophoresis is a promising therapy for palmoplantar hyperhidrosis. Non-affordability and nonavailability of the marketed device restrict its usage for many patients hailing from villages or small cities.

Materials And Methods: In an article named "A simple user-made iontophoresis device for palmoplantar hyperhidrosis" published previously in this journal, a simple inexpensive homemade device that runs on 12 V direct current battery was described. Read More

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December 2018

Autoimmune hypoglycaemia caused by alpha-lipoic acid: a rare condition in Caucasian patients.

Endocrinol Diabetes Metab Case Rep 2018 Dec 11;2018. Epub 2018 Dec 11.

ENETS Center of Excellence, Department of Medicine, University of Verona, Verona, Italy.

Insulin autoimmune syndrome (IAS), a rare cause of autoimmune hyperinsulinaemic hypoglycaemia, is relatively well known in Japan. The incidence in Caucasians is less than one-fifth of that reported in Japanese people, but it is becoming increasingly recognised worldwide in non-Asians as well. Drugs containing sulphydryl groups are known to be associated with the disease in genetically predisposed individuals. Read More

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December 2018
1 Read

New trends in botulinum toxin use in dermatology.

Dermatol Pract Concept 2018 Oct 31;8(4):277-282. Epub 2018 Oct 31.

Department of Dermatology, University of Campania Luigi Vanvitelli, Naples, Italy.

Background: Recent studies have highlighted new botulinum neurotoxin (BoNT) applications in the field of dermatology.

Objective: To review current knowledge of BoNT use in dermatology.

Methods: The literature of the last 5 five years has been reviewed. Read More

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October 2018
1 Read

Thermoregulation in Parkinson disease.

Handb Clin Neurol 2018 ;157:715-725

Department of Neurology, Mayo Clinic, Rochester, MN, United States.

Autonomic dysfunction in Parkinson disease encompasses thermoregulatory symptoms and was first noted by Gowers in the late 19th century when he described abnormal temperature sensation and sweating in Parkinson disease patients. These thermoregulatory symptoms became more recognized in the postlevodopa era when Parkinson disease patients were more readily tested with objective autonomic function tests. Objective thermoregulatory testing in Parkinson disease reveals deficits of sweating and vasomotor tone which often correlate with the severity of other autonomic deficits. Read More

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January 2018
2 Reads

Hemifacial Hyperhidrosis in a Patient With an Apical Non-Small Cell Lung Cancer.

JAMA Oncol 2018 Nov 15. Epub 2018 Nov 15.

Department of Radiation Oncology and Molecular Radiation Sciences, the Johns Hopkins Hospital, Baltimore, Maryland.

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November 2018

Glycopyrronium tosylate in pediatric primary axillary hyperhidrosis: Post hoc analysis of efficacy and safety findings by age from two phase three randomized controlled trials.

Pediatr Dermatol 2018 Nov 19. Epub 2018 Nov 19.

Eastern Virginia Medical School and Virginia Clinical Research, Inc., Norfolk, Virginia.

Objectives: Hyperhidrosis in pediatric patients has been understudied. Post hoc analyses of two phase 3 randomized, vehicle-controlled, 4-week trials (ATMOS-1 [NCT02530281] and ATMOS-2 [NCT02530294]) were performed to assess efficacy and safety of topical anticholinergic glycopyrronium tosylate (GT) in pediatric patients.

Methods: Patients had primary axillary hyperhidrosis ≥ 6 months, average Axillary Sweating Daily Diary (ASDD/ASDD-Children [ASDD-C]) Item 2 (sweating severity) score ≥ 4, sweat production ≥ 50 mg/5 min (each axilla), and Hyperhidrosis Disease Severity Scale (HDSS) ≥ 3. Read More

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November 2018
3 Reads

Use of antipsychotic drugs in dermatology.

Clin Dermatol 2018 Nov - Dec;36(6):765-773. Epub 2018 Aug 16.

Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Antipsychotic drugs can be beneficial in dermatology because of their both central nervous system and peripheral effects. All antipsychotic drugs have a central postsynaptic dopamine D2 receptor blocking effect, which underlies their antipsychotic action. The antipsychotic drugs have varying degrees of histamine H1-receptor, cholinergic muscarinic receptor, and α1-adrenergic receptor blocking effects, which can affect cutaneous perception and the autonomic reactivity of the skin and can be potentially beneficial in the management of certain histamine or sympathetically mediated dermatologic manifestations (eg, urticaria, pruritus, hyperhidrosis). Read More

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August 2018
9 Reads

Use of antiepileptic mood stabilizers in dermatology.

Clin Dermatol 2018 Nov - Dec;36(6):756-764. Epub 2018 Aug 16.

Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Several antiepileptic drugs (AEDs) are approved by the US Food and Drug Administration for the treatment of bipolar disorder (valproic acid, divalproex, lamotrigine, carbamazepine) and some cutaneous neuropathic pain syndromes (carbamazepine, gabapentin, pregabalin). The AEDs may be effective in the management of (1) chronic pruritus, including pruritus due systemic disease, including uremia, neuropathic pain, neuropathic pruritus, and complex cutaneous sensory syndromes, especially where central nervous system (CNS) sensitization plays a role; (2) management of emotional dysregulation and the resultant repetitive self-excoriation or other cutaneous self-injury in patients who repetitively stimulate or manipulate their integument to regulate emotions (prurigo nodularis, lichen simplex chronicus, skin picking disorder, trichotillomania); (3) management of dermatologic clinical manifestations associated with autonomic nervous system activation (hyperhidrosis, urticaria, flushing; these often occur in conjunction with psychiatric disorders with prominent autonomic activation and dysregulation, eg, social anxiety disorder, posttraumatic stress disorder); and (4) when certain anticonvulsants have a direct therapeutic effect (eg, in psoriasis); currently the use of AEDs for such cases is largely experimental. Gabapentin (dosage range 300-3600 mg daily) is the most widely studied AED mood stabilizer in dermatology and is especially effective in situations where CNS sensitization is a mediating factor. Read More

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August 2018
5 Reads

Comparative study of transepidermal water loss in patients with and without hyperhidrosis by closed-chamber measurer in an air-conditioned environment.

Einstein (Sao Paulo) 2018 Nov 8;16(4):eAO4312. Epub 2018 Nov 8.

Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Objective: To evaluate the difference in transepidermal water loss in patients diagnosed with hyperhidrosis and healthy subjects, in an air-conditioned environment.

Methods: Twenty patients diagnosed with hyperhidrosis and 20 healthy subjects were subjected to quantitative assessment using a closed-chamber device, in six previously established sites.

Results: The measurements showed different transepidermal water loss values for healthy subjects and patients with hyperhidrosis, especially in the hands and feet. Read More

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November 2018

Shortening of Incision by "Pinch and Turn-Over Technique" in the Treatment of Axillary Osmidrosis.

Authors:
Eui-Tae Lee

Aesthetic Plast Surg 2018 Nov 9. Epub 2018 Nov 9.

Department of Plastic and Reconstructive Surgery, Chungbuk National University College of Medicine, 1, Chungdae-Ro, Seowon-gu, Cheongju, Chungbuk, 28644, Korea.

Background: The pinch and turn-over technique was developed to minimize the incision in the manual subdermal excision of apocrine glands in axillary osmidrosis for the best cure and fewest complications.

Methods: Through a 2-cm-long incision, peripheral subdermal tissue was excised by the technique under direct vision using intravenous anesthesia and tumescent technique. Ninety-nine axillae in 50 patients including seven secondary cases were operated on from 2009 to 2018. Read More

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November 2018
5 Reads

[The role of the combined balneotherapeutic treatment as the 'add-back therapy' against the background of the anti-hormonal effects of the agonists of gonadotropin-releasing hormone in the women suffering from endometriosis genitalis externa].

Vopr Kurortol Fizioter Lech Fiz Kult 2018 ;95(5):31-39

Pyatigorsk state scientific research institute of balneotherapeiutics, Russian Federal Medical Biological Agency, Pyatigorsk, Russia.

Background: The use of agonists of gonadotropin-releasing hormone (GnRH) for the rehabilitation treatment of the patients presenting with endometriosis genitalis externa is known to significantly enhance the risk of development of hypoestrogenism. The so-called 'add-back-therapy' is carried out as a preventive measure to eliminate hypoestrogenism caused by the intake of GnRH agonists without detriment to the effectiveness of anti-hormonal therapy.

Aim: The objective of the present study was to estimate the effectiveness of the new method ('add-back hormone replacement therapy') in comparison with anti-hormonal therapy with the use of GRH agonists at the stage of the early postoperative medical rehabilitation based on the drinking of mineral waters (MW) and radon therapy (RT) in the patients who had undergone the laparoscopic interventions for the treatment of endometrioid heterotopies of the ovaries (1-3 months post-operatively). Read More

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January 2018
6 Reads

Simultaneous Pheochromocytoma, Paraganglioma, and Papillary Thyroid Carcinoma without Known Mutation.

Case Rep Endocrinol 2018 14;2018:6358485. Epub 2018 Oct 14.

Einstein Medical Center, 5501 Old York Rd., Philadelphia, PA 19141, USA.

Background: Pheochromocytoma/paraganglioma is a rare tumor from neuroendocrine cells. 1/3 of cases have germline mutations. Papillary thyroid carcinoma (PTC) is a common neoplasm from follicular cells of the thyroid. Read More

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October 2018
5 Reads

Sleep disorders and endothelial dysfunction in children with sickle cell anemia.

Sleep Med 2018 Sep 25;53:9-15. Epub 2018 Sep 25.

Department of Pediatrics, School of Medicine, Federal University of Bahia, Salvador, Bahia, 40080-002, Brazil. Electronic address:

Objective: We sought to assess sleep characteristics in children with sickle cell anemia (SCA) to investigate the possible association between sleep-related disorders and parameters of endothelial function.

Methods: Sleep Disturbance Scale for Children (SDSC) and endothelial function variables (flow-mediated dilatation using brachial artery ultrasound, cytokines) were compared in children with SCA and healthy children aged 6-18 years.

Results: Flow-mediated dilation (FMD) median (IQR) values were 10. Read More

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September 2018
4 Reads

Changes in Palm Temperature as Predictor of Long-term Cure of Sympathicotomy for Palmar hyperhidrosis?

J Neurol Surg A Cent Eur Neurosurg 2018 Oct 31. Epub 2018 Oct 31.

Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

Objectives:  To investigate the long-term relationship between intraoperative temperature changes of the palm, treatment effects and compensatory hyperhidrosis (CH).

Methods:  We retrospectively analyzed the data of 41 patients with palmar hyperhidrosis who underwent bilateral endoscopic sympathicotomy 3 to 6 years ago. Before and after the operation, changes in ipsilateral palm temperature were monitored and recorded to evaluate the curative effect of the sympathicotomy. Read More

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October 2018
6 Reads

Topical Glycopyrronium Tosylate for the Treatment of Primary Axillary Hyperhidrosis: Patient-Reported Outcomes from the ATMOS-1 and ATMOS-2 Phase III Randomized Controlled Trials.

Am J Clin Dermatol 2018 Oct 30. Epub 2018 Oct 30.

Saint Louis University, St. Louis, MO, USA.

Background: Glycopyrronium tosylate (GT) is a topical anticholinergic approved in the USA for primary axillary hyperhidrosis in patients aged ≥ 9 years. GT was evaluated for primary axillary hyperhidrosis in replicate, randomized, double-blind, vehicle-controlled, phase III trials. GT reduced sweating severity and production versus vehicle and was generally well tolerated. Read More

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October 2018
6 Reads

A novel mutation in the gene results in the unusual phenotype of palmoplantar keratoderma with digital clubbing and hyperhidrosis.

JAAD Case Rep 2018 Oct 12;4(9):950-952. Epub 2018 Oct 12.

Department of Dermatology, American University of Beirut, Beirut, Lebanon.

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October 2018
4 Reads

Genetic polymorphism analysis of patients with primary hyperhidrosis.

Clin Cosmet Investig Dermatol 2018 11;11:477-483. Epub 2018 Oct 11.

Alabama College of Osteopathic Medicine, Dothan, AL, USA,

Background: Hyperhidrosis affects 220 million people worldwide. The hallmark of this condition is excessive sweating, which negatively impacts the social, emotional, and occupational lives of these individuals. A familial predisposition has been established; however, the specific genes involved have yet to be identified. Read More

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October 2018
3 Reads

Efficacy of a mandibular advancement intraoral appliance (MOA) for the treatment of obstructive sleep apnea syndrome (OSAS) in pediatric patients: A pilot-study.

Med Oral Patol Oral Cir Bucal 2018 Nov 1;23(6):e656-e663. Epub 2018 Nov 1.

Av. Ipiranga, 6681, 90619-900 Porto Alegre RS, Brazil,

Background: To evaluate the treatment efficacy of a mandibular advancement intraoral appliance (MOA) for treatment of obstructive sleep apnea syndrome (OSAS) in pediatric patients.

Material And Methods: Eighteen patients (mean=8.39 years old, women=44. Read More

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November 2018
1 Read

Autonomic Disorders.

Authors:
Peter Novak

Am J Med 2018 Oct 9. Epub 2018 Oct 9.

Department of Neurology, Brigham and Women's Faulkner Hospital, Harvard Medical School, Boston, MA. Electronic address:

Autonomic complaints are frequently encountered in clinical practice. They can be due to primary autonomic disorders or secondary to other medical conditions. Primary autonomic disorders can be categorized as orthostatic intolerance syndromes and small fiber neuropathies; the latter are associated with autonomic failure, pain, or their combinations. Read More

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October 2018
17 Reads

A randomized, double-blind, placebo-controlled, crossover study to evaluate the human abuse liability of solriamfetol, a selective dopamine and norepinephrine reuptake inhibitor.

J Psychopharmacol 2018 Dec 1;32(12):1351-1361. Epub 2018 Oct 1.

6 Department of Pharmacology and Toxicology, Medicine, and Psychiatry, University of Toronto, ON, Canada.

Background:: This study evaluated the human abuse potential of solriamfetol (formerly JZP-110), a selective dopamine and norepinephrine reuptake inhibitor with robust wake-promoting effects.

Methods:: Adults with a recent history of recreational polydrug use, including stimulants, and who met criteria in a Qualification Phase were randomized to one of six sequences in a Test Phase. Each Test Phase sequence included a single administration of placebo, solriamfetol (300, 600, and 1200 mg), and phentermine (45 and 90 mg), with a two-day washout between periods. Read More

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December 2018
8 Reads

Relationship between depression scores and degree of skin perspiration: A novel cross-sectional study.

Int Wound J 2018 Sep 24. Epub 2018 Sep 24.

Nursing and Physical Therapy Department, Institute of Biomedicine (IBIOMED), Faculty of Health Sciences, Universidad de León, Ponferrada, León, Spain.

Primary hyperhidrosis (PH) is a common pathological condition related to excessive sweating. It may be associated with depression. Therefore, the main aim of this study was to analyse and compare depression scores between subjects without PH (degree-I) and patients with PH (degrees-II, -III, and -IV). Read More

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September 2018
1 Read

Clinical evaluation of an antiperspirant for hyperhidrosis.

G Ital Dermatol Venereol 2018 Sep 20. Epub 2018 Sep 20.

Dipartimento di Bioscienze Mediche, Chirurgiche Ortopediche, IRCCS Ospedale Galeazzi, Università degli Studi di Milano, Milan, Italy.

Background: Hyperhidrosis is a fairly common condition characterized by excessive sweating, usually in axillary areas. Although not involving major health problems, it is a significant psychological distress to those affected, compromising their social life. The first line of defense used to address this problem are antiperspirants, usually containing aluminum salts, capable of blocking the excessive sweating. Read More

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September 2018

No sweat: Favorable outcomes of hyperhidrosis surgery with age.

J Thorac Cardiovasc Surg 2018 Oct 2;156(4):1759-1760. Epub 2018 Aug 2.

Department of Surgery, Yale New Haven Hospital, Yale University, New Haven, Conn.

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October 2018
4 Reads

Percutaneous Radiofrequency Ablation for Hyperhidrosis: Ready for Primetime?

Semin Thorac Cardiovasc Surg 2018 15;30(3):367-368. Epub 2018 Sep 15.

Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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September 2018

Interventional management of hyperhidrosis in secondary care: where do we go from here?

Authors:
A Durack

Br J Dermatol 2018 Sep;179(3):555-556

Department of Dermatology, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, U.K.

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September 2018

[Hyperhidrosis-aetiopathogenesis, diagnosis, clinical symptoms and treatment].

Authors:
J Wohlrab B Kreft

Hautarzt 2018 Oct;69(10):857-869

Universitätsklinik und Poliklinik für Dermatologie und Venerologie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle (Saale), Deutschland.

Although primary hyperhidrosis is a common disease, secondary symptomatic hyperhidrosis is rather rare. Primary hyperhidrosis is a complex neuropathic dysregulation with a genetic predisposition and is diagnosed when patients show pathologic sweating patterns and excessive sweating for at least 6 months and fulfill at least four of the following criteria: affected areas are axillae and/or palms and/or soles and/or forehead; symmetry; no night sweating; at least once a week; onset before the age of 25; positive family history; negative impact on daily activities. Frequently used therapies are topical aluminum salts and anticholinergics, iontophoresis in water, and intracutaneous botulinum toxin. Read More

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October 2018

CT-Guided Chemical Thoracic Sympathectomy versus Botulinum Toxin Type A Injection for Palmar Hyperhidrosis.

Thorac Cardiovasc Surg 2018 Sep 14. Epub 2018 Sep 14.

Department of Plastic Surgery, General Hospital of Guangzhou Military Command of PLA, Guangzhou, Guangdong, People's Republic of China.

Background:  The present study aimed to evaluate and compare the efficacy of botulinum toxin type A (BTX-A) injection versus thoracic sympathectomy for idiopathic palmar hyperhidrosis.

Methods:  Fifty-one patients with idiopathic palmar hyperhidrosis were treated with either BTX-A injection or thoracic sympathectomy between March 2013 and April 2016. The severity of palmar hyperhidrosis was qualitatively measured via the Hyperhidrosis Disease Severity Scale (HDSS). Read More

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September 2018
6 Reads

Excessive Sweating (Hyperhidrosis).

Authors:

Am Fam Physician 2018 Jun;97(11):Online

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Hyperhidrosis: Management Options.

Am Fam Physician 2018 Jun;97(11):729-734

The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Hyperhidrosis is excessive sweating that affects patients' quality of life, resulting in social and work impairment and emotional distress. Primary hyperhidrosis is bilaterally symmetric, focal, excessive sweating of the axillae, palms, soles, or craniofacial region not caused by other underlying conditions. Secondary hyperhidrosis may be focal or generalized, and is caused by an underlying medical condition or medication use. Read More

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June 2018
6 Reads

Growth hormone and prolactin-staining tumors causing acromegaly: a retrospective review of clinical presentations and surgical outcomes.

J Neurosurg 2018 Sep 14:1-7. Epub 2018 Sep 14.

Department of Neurosurgery, University of California, San Francisco, California.

OBJECTIVE Acromegaly results in disfiguring growth and numerous medical complications. This disease is typically caused by growth hormone (GH)-secreting pituitary adenomas, which are treated first by resection, followed by radiation and/or medical therapy if needed. A subset of acromegalics have dual-staining pituitary adenomas (DSPAs), which stain for GH and prolactin. Read More

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September 2018
1 Read

Minimally invasive approaches to axillary osmidrosis treatment: A comparison between superficial liposuction with automatic shaver curettage, subcutaneous laser treatment, and microwave-based therapy with a modified technique.

J Cosmet Dermatol 2018 Sep 10. Epub 2018 Sep 10.

Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou City, Guangdong Province, China.

Background: Minimally invasive techniques, including superficial liposuction with automatic shaver curettage (LC), subcutaneous laser treatment, and microwave-based therapy have been developed to treat osmidrosis. Few studies have compared these three techniques in relation to clinical efficacy, life quality improvement, and downtime.

Aims: We aim to evaluate clinical results and life quality improvement, in addition to downtime and complications, between these three techniques. Read More

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September 2018
4 Reads
1.000 Impact Factor

Long-term follow-up in pediatric patients with paroxysmal hypothermia (Shapiro's syndrome).

Eur J Paediatr Neurol 2018 Aug 29. Epub 2018 Aug 29.

Neurology Unit, S. Anna Hospital, Como, Italy. Electronic address:

Introduction: Shapiro syndrome (SS) is characterized by spontaneous recurrent episodes of hypothermia, hyperhidrosis and corpus callosum (CC) agenesis. Less than 60 cases have been reported to date and the pathogenic mechanism as well as the prognosis of this syndrome are still debated. We describe the clinical features and long-term follow-up of a pediatric cohort of SS patients. Read More

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August 2018
6 Reads

Long-term outcomes following sweat gland excision for axillary hyperhidrosis.

J Dtsch Dermatol Ges 2018 Oct 5;16(10):1286-1288. Epub 2018 Sep 5.

Department of Dermatology, Salzburg State Hospital, University Medical Center of Paracelsus Medical University, Salzburg, Austria.

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October 2018

Botulinum toxin type A enhances the inhibitory spontaneous postsynaptic currents on the substantia gelatinosa neurons of the subnucleus caudalis in immature mice.

Korean J Physiol Pharmacol 2018 Sep 27;22(5):539-546. Epub 2018 Aug 27.

Department of Oral Physiology, School of Dentistry & Institute of Oral Bioscience, Chonbuk National University, Jeonju 54896, Korea.

Botulinum toxin type A (BoNT/A) has been used therapeutically for various conditions including dystonia, cerebral palsy, wrinkle, hyperhidrosis and pain control. The substantia gelatinosa (SG) neurons of the trigeminal subnucleus caudalis (Vc) receive orofacial nociceptive information from primary afferents and transmit the information to higher brain center. Although many studies have shown the analgesic effects of BoNT/A, the effects of BoNT/A at the central nervous system and the action mechanism are not well understood. Read More

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September 2018
1 Read

Free-standing ambulatory endoscopic transthoracic sympathectomy made with a urological resectoscope.

J Minim Access Surg 2018 Sep 3. Epub 2018 Sep 3.

Department of Ambulatory Surgery, General Surgery Unit, President Nestor Kirchner Hospital, San Miguel de Tucuman, Argentina.

The endoscopic transthoracic sympathectomy (ETS) is an efficient procedure designed to treat palmar/axillary hyperhidrosis, now, we can present an original form to do this surgery with a single incision and using an urological resectoscope, always in a free-standing ambulatory public system in the province of Tucumán, in Argentina. Read More

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September 2018

Sweaty feet in adolescents-Early use of botulinum type A toxin in juvenile plantar hyperhidrosis.

Pediatr Dermatol 2018 Nov 4;35(6):784-786. Epub 2018 Sep 4.

Hospital for Children and Adolescents, University of Heidelberg, Heidelberg, Germany.

Background/objectives: Plantar hyperhidrosis can have severe social effects on children and adolescents. Therapeutic options include antiperspirants and surgical interventions (eg, sympathectomy). Botulinum type A toxin is approved for axillary hyperhidrosis in adults only. Read More

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November 2018

A Case of Mercury Toxicity Complicated by Acute Inflammatory Demyelinating Polyneuropathy.

J Child Neurol 2018 Nov 28;33(13):817-819. Epub 2018 Aug 28.

1 University of Tennessee College of Medicine, Le Bonheur Children's Hospital, Memphis, TN, USA.

A 13-year-old African American male presented with 2 months of subacute altered mental status, ptosis, areflexia, disordered gait, constipation, weight loss, abdominal and testicular pain, and hyperhidrosis. Initial workup at our facility was unrevealing until elevated serum mercury level was detected. Diagnosis of mercury toxicity was confirmed, and chelation therapy with succimer was started. Read More

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November 2018
10 Reads

First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors.

Clin Cancer Res 2018 Aug 21. Epub 2018 Aug 21.

Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

The NHS-IL12 immunocytokine is composed of two IL12 heterodimers fused to the NHS76 antibody. Preclinical studies have shown that this antibody targets IL12 to regions of tumor necrosis by binding histones on free DNA fragments in these areas, resulting in enhanced antitumor activity. The objectives of this phase I study were to determine the maximum tolerated dose (MTD) and pharmacokinetics of NHS-IL12 in subjects with advanced solid tumors. Read More

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August 2018
6 Reads

Primum non nocere: Anticholinergics and dementia.

Authors:
Dirk M Elston

J Am Acad Dermatol 2018 Sep;79(3):439-440

Department of Dermatology and Dermatologic Surgery Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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September 2018
5 Reads

Sparing subcutaneous septa avoids skin necrosis in the treatment of axillary bromhidrosis with suction-curettage shaving.

J Cosmet Dermatol 2018 Aug 9. Epub 2018 Aug 9.

Department of Plastic Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Background: Surgical treatment of axillary bromhidrosis or hyperhidrosis involves the removal of apocrine glands. There are several methods to eliminate apocrine glands; however, many methods reported significant rates of skin necrosis. To avoid this problem while preserving comparable results, we used a modified method sparing several subcutaneous septa, which successfully avoided skin necrosis completely in our series of 19 consecutive cases. Read More

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August 2018
7 Reads

A pilot study towards long-term thermal comfort research for lower-limb prosthesis wearers.

Prosthet Orthot Int 2018 Aug 6:309364618791604. Epub 2018 Aug 6.

1 University College London, London, UK.

Background: Thermal discomfort among lower-limb prosthesis wearers is prevalent with social and medical consequences.

Objectives: This study aimed to verify the feasibility of out-of-laboratory thermal comfort studies.

Study Design: Repeated measures pilot study. Read More

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August 2018
2 Reads

Number of Preoperative Hyperhidrosis Sites Does Not Affect the Sympathectomy Postoperative Results and Compensatory Hyperhidrosis Occurrence.

Thorac Cardiovasc Surg 2018 Aug 2. Epub 2018 Aug 2.

Division of Vascular and Endovascular, Department of Surgery, Hospital das Clínicas da Faculdade de Medicina, Pinheiros, University of São Paulo School of Medicine, University of São Paulo, São Paulo, Brazil.

Background:  Patients with primary hyperhidrosis present with sweating in two or more sites in nearly 85% of cases. In this study, we examined whether the number of hyperhidrosis sites is related to the surgery outcomes.

Methods:  One hundred ninety-three hyperhidrosis patients who underwent bilateral videothoracoscopic sympathectomy after failure or dissatisfaction with clinical treatment were distributed into three groups based on the number of hyperhidrosis sites (one site, two sites, and three or more sites of hyperhidrosis). Read More

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August 2018
13 Reads

Early results of new endoscopic thoracic sympathectomy for craniofacial hyperhidrosis.

J Thorac Dis 2018 Jun;10(6):3627-3631

Department of Thoracic and Cardiovascular Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background: Endoscopic thoracic sympathectomy (ETS) has been considered as a definitive treatment for hyperhidrosis. However, despite its well-established success rate, surgical treatment for craniofacial hyperhidrosis (CFH) is rarely performed due to the possibility of fatal complications and compensatory sweating. The aim of this study was to evaluate the safety and efficacy of our newly developed method of ETS for CFH, based on early results. Read More

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June 2018
15 Reads

Hyperhidrosis: prevalence and impact on quality of life.

J Bras Pneumol 2018 Jul-Aug;44(4):292-298. Epub 2018 Jul 30.

. Serviço de Cirurgia Torácica, Departamento de Cirurgia e Ortopedia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista - UNESP - Botucatu (SP) Brasil.

Objective: To determine the prevalence of primary hyperhidrosis in the city of Botucatu, Brazil, and to evaluate how this disorder affects the quality of life in those suffering from it.

Methods: A population survey was conducted in order to identify cases of hyperhidrosis among residents in the urban area of the city, selected by systematic cluster sampling. In accordance with the census maps of the city, the sample size should be at least 4,033 participants. Read More

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July 2018
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The relation between age and outcomes of thoracic sympathectomy for hyperhidrosis: The older the better.

J Thorac Cardiovasc Surg 2018 Oct 7;156(4):1748-1756. Epub 2018 Jun 7.

Department of Vascular and Endovascular Surgery, Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil; Vascular and Endovascular Division, Department of Surgery, University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil.

Objective: Several factors may potentially influence the efficacy and patient satisfaction after bilateral thoracic sympathectomy as the treatment for hyperhidrosis, but few studies have specifically analyzed the impact of age on the efficacy of this treatment, the occurrence of compensatory hyperhidrosis (CH), and variations in the quality of life.

Methods: We retrospectively analyzed the effect of age, body mass index, surgical techniques, quality of life before surgery, betterment in the quality of life after surgery, clinical improvement in sweating at the main site, and the occurrence and intensity of CH in patients with hyperhidrosis (n = 1633) who underwent bilateral sympathectomy.

Results: Quality of life improved in more than 90% of patients, and severe CH occurred in 5. Read More

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October 2018

The Blend of Taurine and Aloe Vera Extract Boosts Action Against Skin Irritation: and Clinical Evaluations.

J Cosmet Sci 2018 May/Jun;69(3):213-228

Colgate-Palmolive Company, Piscataway, NJ (J.M.S., S.C., N.S., Z.N., L.P.).

Regular usage of cosmetic products and drugs in dermatological vehicles may cause irritant contact dermatitis. For example, aluminum chloride (AlCl), the most efficacious antiperspirant salt to treat hyperhidrosis, shows high irritancy potential. To mitigate the irritant contact dermatitis caused by topical application of products containing AlCl, we investigated the anti-irritating effects of aloe extract and taurine and . Read More

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September 2018
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