4,565 results match your criteria Hyperhidrosis


[Impact of Selective Quality of Life Analysis in Patients with Local Hyperhidrosis after Sympathicus Clipping].

Zentralbl Chir 2019 Feb 22. Epub 2019 Feb 22.

Thoraxchirurgische Abteilung in der Chirurgischen Klinik, Universitätsklinikum, Friedrich-Alexander-Universität Erlangen-Nürnberg, Deutschland.

Introduction: Hyperhidrosis (HH) is associated with physical and psychological restrictions. The treatment includes both conservative and surgical methods and aims to permanently improve the quality of life (QoL) of those affected. Endoscopic sympathetic blockade (ESB) is an established surgical therapeutic method and is considered effective when conservative treatment options fail. Read More

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http://dx.doi.org/10.1055/a-0808-5003DOI Listing
February 2019

Pachydermoperiostosis (Touraine-Solente-Gole syndrome): a case report.

J Med Case Rep 2019 Feb 21;13(1):39. Epub 2019 Feb 21.

Tribhuvan University Institute of Medicine, Maharajgunj, Kathmandu, Nepal.

Background: Pachydermoperiostosis (PDP) is a rare disorder characterized by clubbing of the fingers, thickening of the skin (pachyderma), and excessive sweating (hyperhidrosis). It typically appears during childhood or adolescence, often around the time of puberty, and progresses slowly. Clinical presentations of PDP can be confused with secondary hypertrophic osteoarthropathy, psoriatic arthritis, rheumatoid arthritis, thyroid acropachy, and acromegaly. Read More

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http://dx.doi.org/10.1186/s13256-018-1961-zDOI Listing
February 2019

Hyperhidrotic Macrodactylism Caused by Osteoid Osteoma: A Case Report and Review of the Literature.

J Foot Ankle Surg 2019 Feb 8. Epub 2019 Feb 8.

Professor, Department of Orthopedics, The First Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China. Electronic address:

Macrodactylism or macrodactyly is referred to as congenital deformity of fingers or toes, and the corresponding incidence rate is relatively low. In this article, we describe a young male with macrodactylism of the second toe of his right foot. He was suffering from persistent pain, overgrowth, and hyperhidrosis of the involved toe. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.09.008DOI Listing
February 2019
2 Reads

Longitudinal follow-up of cardiac vagal activity in individuals undergoing endoscopic thoracic sympathectomy.

J Bras Pneumol 2018 Nov-Dec;44(6):456-460

. Programa de Pós-Graduação Strictu Sensu, Universidade do Estado do Rio de Janeiro - UERJ - Rio de Janeiro (RJ) Brasil.

Objective: To conduct a longitudinal investigation of cardiac vagal activity (CVA) by measuring resting HR and calculating the cardiac vagal index (CVI) in individuals undergoing sympathectomy for the treatment of primary hyperhidrosis.

Methods: This was a descriptive longitudinal study involving 22 patients, 13 of whom were female. The mean age was 22. Read More

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http://dx.doi.org/10.1590/S1806-37562017000000464DOI Listing
December 2017

Using gauze to evenly spread starch for hyperhidrosis testing.

J Am Acad Dermatol 2019 Jan 30. Epub 2019 Jan 30.

Division of Dermatology, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.01.058DOI Listing
January 2019

The Etiology, Diagnosis and Management of Hyperhidrosis: A Comprehensive Review. Part I. Etiology and Clinical Work-Up.

J Am Acad Dermatol 2019 Jan 30. Epub 2019 Jan 30.

Rutgers- Robert Wood Johnson Medical School, Department of Dermatology, 1 World's Fair Drive, Suite 2400, Somerset, NJ 08873.

Hyperhidrosis (HH) is a dermatologic disorder defined by sweat production beyond the thermoregulatory requirements. Clinically, HH is diagnosed when excess sweating creates significant emotional, physical, or social discomfort, causing negative impact on the patient's quality of life. Existing data imply that this condition may affect at least 4. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.12.071DOI Listing
January 2019

The Etiology, Diagnosis and Management of Hyperhidrosis: A Comprehensive Review. Part II. Therapeutic Options.

J Am Acad Dermatol 2019 Jan 30. Epub 2019 Jan 30.

Rutgers- Robert Wood Johnson Medical School, Department of Dermatology, 1 World's Fair Drive, Suite 2400, Somerset, NJ 08873.

Hyperhidrosis (HH) is a chronic disorder of excess sweat production that may have a significant adverse effect on quality of life. A variety of treatment modalities currently exist to manage HH. Initial treatment includes lifestyle and behavioral recommendations. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.11.066DOI Listing
January 2019
8 Reads

Bilateral brachial plexus injury after MiraDry® procedure for axillary hyperhidrosis: a case report.

World Neurosurg 2019 Jan 28. Epub 2019 Jan 28.

Department of Orthopedic Surgery. Electronic address:

Multiple treatments are available for primary axillary hyperhidrosis, including non-invasive, microwave based thermal treatments designed to destroy sweat glands in the axilla. Often these procedures involve local anesthetic injection to the axilla, followed by placement of the microwave emitter onto the skin and applying the heat treatment to varying depths of the subcutaneous tissues. CASE REPORT: A 49-year old, thin and active woman (BMI 19. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.093DOI Listing
January 2019
2 Reads

The quality of life and satisfaction rate of patients with upper limb hyperhidrosis before and after bilateral endoscopic thoracic sympathectomy.

Saudi J Anaesth 2019 Jan-Mar;13(1):16-22

Department of Surgery, Thoracic Surgery Division, College of Medicine, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia.

Background: Hyperhidrosis is a functional disorder identified by excessive sweating. Its incidence is approximately 1% in any population. Bilateral endoscopic thoracic sympathectomy (BETS) intervention is the definitive treatment of choice for palmar and axillary hyperhidrosis. Read More

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http://dx.doi.org/10.4103/sja.SJA_335_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329233PMC
January 2019
5 Reads

Targeting Gray Rami Communicantes in Selective Chemical Lumbar Sympathectomy.

J Vis Exp 2019 Jan 10(143). Epub 2019 Jan 10.

Department of Interventional Radiology and Vascular Surgery, Peking University Third Hospital; Wound Healing Center, Peking University Third Hospital.

Chemical lumbar sympathectomy (CLS) is a commonly used, minimally invasive procedure for the treatment of conditions including ischemic diseases of the lower extremities, hyperhidrosis, etc. It is commonly practiced to position the puncture needle tip in front of the anterior fascia of the psoas major muscle and inject the inactivating agent around the sympathetic trunk, which is defined as conventional CLS. Although relatively rare, ureteropelvic damage is the most frequently reported complication of conventional CLS and can cause serious harm to patients. Read More

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http://dx.doi.org/10.3791/58894DOI Listing
January 2019
1 Read

Effectiveness of bilateral clipping of the thoracic sympathetic chain for the treatment of severe palmar and/or axillary hyperhidrosis and facial flushing.

Cir Esp 2019 Jan 23. Epub 2019 Jan 23.

Cirugía Torácica, Hospital Universitari Sagrat Cor, Barcelona, España; Cirugía Torácica, Hospital Clínic, Universitat de Barcelona, Barcelona, España.

Introduction: Division of the thoracic sympathetic chain is the standard treatment for severe palmar and/or axillary hyperhidrosis and facial flushing. Clipping is an alternative option which allows the block to be reverted in cases of intolerable compensatory sweating.

Methods: This is a prospective study performed to assess: a) results of clipping of the thoracic sympathetic chain in patients with palmar and/or axillary hyperhidrosis and facial flushing; and b) to determine the improvement obtained after removal of the clip in patients with unbearable compensatory sweating. Read More

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http://dx.doi.org/10.1016/j.ciresp.2018.11.009DOI Listing
January 2019

The Association between Obesity and Hyperhidrosis: A Nationwide, Cross Sectional Study of 2.77 Million Israeli Adolescents.

J Am Acad Dermatol 2019 Jan 21. Epub 2019 Jan 21.

The Israel Defense Forces Medical Corps, Tel Hashomer, Ramat Gan, Israel; Sackler School of Medicine, Tel-Aviv University, Israel; Department of Military Medicine, Hebrew University, Jerusalem, Israel; Department of Medicine and the Dr. Pinchas Bornstein Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.01.019DOI Listing
January 2019
1 Read

Topical Treatment of Primary Focal Hyperhidrosis, Part 1.

Authors:
Eyal Zur

Int J Pharm Compd 2019 Jan-Feb;23(1):23-31

Compounding Pharmacist, Israel.

Primary focal hyperhidrosis is idiopathic, localized, uncontrollable, excessive, and unpredictable sweating beyond what is necessary to regulate body temperature. Primary hyperhidrosis is thought to affect approximately 2% to 3% of the population, and its effect on a patient's quality of life is very significant. Primary focal hyperhidrosis can be managed using various therapeutic options, including drugs (topical and systemic), nonsurgical interventions (e. Read More

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January 2019

Clinical profile of recurrent vesicular palmoplantar dermatitis in children and adolescents.

Clin Cosmet Investig Dermatol 2019 3;12:23-28. Epub 2019 Jan 3.

Sector of Dermatology, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Previously known as dyshidrosis, recurrent vesicular palmoplantar dermatitis (RVPD) is presented as severe eruption of nonerythematous, symmetrical vesicles or bullae located along the lateral sides of fingers, on the palmar or plantar areas, and developing into a chronic and recurrent condition. Although very frequently observed on the hands, there are no specific studies about such eczema in children and adolescents.

Objectives: To report on the RVPD clinical profile in children and adolescents, and monitor the association of RVPD with seasonal variations, hyperhidrosis, atopy and nickel sulfate. Read More

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http://dx.doi.org/10.2147/CCID.S150778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322509PMC
January 2019
2 Reads

A Retrospective Analysis of the use of Tap Water Iontophoresis for Focal Hyperhidrosis at a District General Hospital: The Patients' Perspective.

J Dermatolog Treat 2019 Jan 16:1-9. Epub 2019 Jan 16.

a Dermatology Department , Croydon University Hospital , Surrey , UK.

Tap water iontophoresis as a treatment for focal hyperhidrosis, is given as an initial series of treatments in hospital followed by home maintenance treatments. Our study assessed quality of life and perception of hyperhidrosis with the use of iontophoresis. All patients treated with iontophoresis at our hospital from 2012 - 2017 were retrospectively assessed (n = 82, mean age 34 years; 60% female). Read More

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http://dx.doi.org/10.1080/09546634.2019.1569751DOI Listing
January 2019
3 Reads

Pourfour du Petit Syndrome: A Rare Association With Cluster Headache.

Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):e15-e16

Department of Ophthalmology, Nîmes University Hospital, Nîmes Cedex 9.

Pourfour du Petit syndrome is an uncommon cause of eyelid retraction, associated with unilateral mydriasis and hemifacial hyperhidrosis. This syndrome is caused by hyperactivity of the ipsilateral oculosympathetic pathway and needs to be recognized because it has an opposite clinical presentation but the same topographic and diagnostic value as Horner syndrome. The authors report a rare case of Pourfour du Petit syndrome associated with cluster headache and discuss pathophysiological hypotheses, clinical presentation, complementary exams, pharmacologic testing, treatment options, and prognosis. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001281DOI Listing
January 2019
2 Reads

Autonomic dysfunction in Parkinson disease and animal models.

Clin Auton Res 2019 Jan 2. Epub 2019 Jan 2.

Preclinical Parkinson's Research Program, Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.

Parkinson disease has traditionally been classified as a movement disorder, despite patients' accounts of diverse symptoms stemming from impairments in numerous body systems. Today, Parkinson disease is increasingly recognized by clinicians and scientists as a complex neurodegenerative disorder featuring both motor and nonmotor manifestations concomitant with pathology throughout all major branches of the nervous system. Dysfunction of the autonomic nervous system, or dysautonomia, is a common feature of Parkinson disease. Read More

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http://link.springer.com/10.1007/s10286-018-00584-7
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http://dx.doi.org/10.1007/s10286-018-00584-7DOI Listing
January 2019
3 Reads

Examining hyperhidrosis: an update on new treatments.

Authors:
Carolyn I Jacob

Am J Manag Care 2018 Dec;24(23 Suppl):S496-S501

Director, Chicago Cosmetic Surgery and Dermatology; affiliate clinical instructor, Northwestern University Feinberg School of Medicine, Chicago, IL. Email:

Primary hyperhidrosis is a debilitating condition that causes significant distress and financial burden for affected patients, triggering them to seek medical care for their excessive sweating. Once a diagnosis of primary hyperhidrosis has been established, treatment is initiated to help control sweat production and increase quality of life. While there are no current guidelines in the United States for the treatment of primary hyperhidrosis, there are International Hyperhidrosis Society guidelines that clinicians can use. Read More

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December 2018
6 Reads

Hyperhidrosis and its impact on those living with it.

Am J Manag Care 2018 Dec;24(23 Suppl):S491-S495

Department of Dermatology, Emory University School of Medicine, Atlanta, GA. Email:

Sweating plays a vital role for humans. However, excessive sweating, also called hyperhidrosis, is a condition resulting in sweating beyond what is physiologically necessary. The increased rate of sweating is not caused by external stimuli or temperature fluctuations, as with an individual without hyperhidrosis. Read More

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December 2018
7 Reads

[Nagashima-type palmoplantar keratoderma: A little-known palmoplantar keratoderma in Europe].

Ann Dermatol Venereol 2019 Feb 21;146(2):125-130. Epub 2018 Dec 21.

Service de dermatologie, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 9, France. Electronic address:

Background: Herein we present a case of palmoplantar keratoderma (PPK) in a young adopted girl of Chinese origin living in France.

Observation: The patient, aged six years, had presented transgressive PPK since birth, as well as erythema progressing in congestive inflammatory episodes, palmoplantar hyperhidrosis and progressive characteristics (moderate hyperkeratosis in areas of rubbing other than the palms and soles, namely the elbows and knees). Histopathological examination of a skin biopsy revealed a thick epidermis with lengthening and thickening of crests. Read More

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http://dx.doi.org/10.1016/j.annder.2018.11.005DOI Listing
February 2019
8 Reads

[Occupational characteristics and clinical manifestations of 245 cases of occupational brucellosis].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Oct;36(10):755-758

HulunBuir People's Hospital, Department of Brucellosis, HulunBuir Clinical Medical College, Inner Mongolia University for Nationalitie, HulunBuir 021008, China.

To analyse epidemiological, clinical characteristics and laboratory examination results of 245 occupational brucellosis form 2008 to 2018, which providing theoretical basis for prevention and control of occupational brucellosis. Based on the China Center for Disease Control and Prevention Information System, a database of occupational brucellosis cases in HunlunBuir from January 2008 to July 2018 was established. The Epidemiological characteristics, Clinical manifestation, laboratory examination of 245 occupational brucellosis and 359 without occupational brucellosis were comparatively analyzed about the same period. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2018.10.009DOI Listing
October 2018

Lithium Treatment Is Safe in Children With Intellectual Disability.

Front Mol Neurosci 2018 22;11:425. Epub 2018 Nov 22.

Henan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Lithium is a widely used and effective treatment for individuals with psycho-neurological disorders, and it exhibits protective and regenerative properties in multiple brain injury animal models, but the clinical experience in young children is limited due to potential toxicity. As an interim analysis, this paper reports the safety/tolerability profiles of low-dose lithium treatment in children with intellectual disability (ID) and its possible beneficial effects. In a randomized, single-center clinical trial, 124 children with ID were given either oral lithium carbonate 6 mg/kg twice per day or the same dose of calcium carbonate as a placebo ( = 62/group) for 3 months. Read More

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00425
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http://dx.doi.org/10.3389/fnmol.2018.00425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262083PMC
November 2018
12 Reads

Short-Term Clinical Outcomes and Safety Associated With Percutaneous Radiofrequency Treatment for Excessive Sweating.

Aesthet Surg J 2018 Dec 9. Epub 2018 Dec 9.

Plastic surgeon in private practice in Osaka City, Japan.

Background: Primary excessive sweating of the axilla affects approximately 3.12% of the US population and has a negative impact on individuals' lives.

Objectives: We report the safety and effectiveness up to 90 days after treating excessive sweating with percutaneous radiofrequency when using a standardized protocol. Read More

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http://dx.doi.org/10.1093/asj/sjy277DOI Listing
December 2018
5 Reads

A Pocket-Friendly and Sustainable Iontophoresis Apparatus for Palmoplantar Hyperhidrosis: Advancement over a Previously Described Homemade Design.

J Cutan Aesthet Surg 2018 Jul-Sep;11(3):153-156

Department of Dermatology, People's College of Medical Sciences and Research Centre, People's University, Bhopal, Madhya Pradesh, India.

Introduction And Objectives: Tap water iontophoresis is a promising therapy for palmoplantar hyperhidrosis. Non-affordability and nonavailability of the marketed device restrict its usage for many patients hailing from villages or small cities.

Materials And Methods: In an article named "A simple user-made iontophoresis device for palmoplantar hyperhidrosis" published previously in this journal, a simple inexpensive homemade device that runs on 12 V direct current battery was described. Read More

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http://dx.doi.org/10.4103/JCAS.JCAS_58_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243828PMC
December 2018
1 Read

Autoimmune hypoglycaemia caused by alpha-lipoic acid: a rare condition in Caucasian patients.

Endocrinol Diabetes Metab Case Rep 2018 Dec 11;2018. Epub 2018 Dec 11.

ENETS Center of Excellence, Department of Medicine, University of Verona, Verona, Italy.

Insulin autoimmune syndrome (IAS), a rare cause of autoimmune hyperinsulinaemic hypoglycaemia, is relatively well known in Japan. The incidence in Caucasians is less than one-fifth of that reported in Japanese people, but it is becoming increasingly recognised worldwide in non-Asians as well. Drugs containing sulphydryl groups are known to be associated with the disease in genetically predisposed individuals. Read More

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https://edm.bioscientifica.com/view/journals/edm/2018/1/EDM1
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http://dx.doi.org/10.1530/EDM-18-0011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300856PMC
December 2018
2 Reads

New trends in botulinum toxin use in dermatology.

Dermatol Pract Concept 2018 Oct 31;8(4):277-282. Epub 2018 Oct 31.

Department of Dermatology, University of Campania Luigi Vanvitelli, Naples, Italy.

Background: Recent studies have highlighted new botulinum neurotoxin (BoNT) applications in the field of dermatology.

Objective: To review current knowledge of BoNT use in dermatology.

Methods: The literature of the last 5 five years has been reviewed. Read More

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http://dx.doi.org/10.5826/dpc.0804a05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246063PMC
October 2018
1 Read

Thermoregulation in Parkinson disease.

Handb Clin Neurol 2018 ;157:715-725

Department of Neurology, Mayo Clinic, Rochester, MN, United States.

Autonomic dysfunction in Parkinson disease encompasses thermoregulatory symptoms and was first noted by Gowers in the late 19th century when he described abnormal temperature sensation and sweating in Parkinson disease patients. These thermoregulatory symptoms became more recognized in the postlevodopa era when Parkinson disease patients were more readily tested with objective autonomic function tests. Objective thermoregulatory testing in Parkinson disease reveals deficits of sweating and vasomotor tone which often correlate with the severity of other autonomic deficits. Read More

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http://dx.doi.org/10.1016/B978-0-444-64074-1.00043-4DOI Listing
January 2018
9 Reads

Hemifacial Hyperhidrosis in a Patient With an Apical Non-Small Cell Lung Cancer.

JAMA Oncol 2018 Nov 15. Epub 2018 Nov 15.

Department of Radiation Oncology and Molecular Radiation Sciences, the Johns Hopkins Hospital, Baltimore, Maryland.

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http://dx.doi.org/10.1001/jamaoncol.2018.4597DOI Listing
November 2018

Glycopyrronium tosylate in pediatric primary axillary hyperhidrosis: Post hoc analysis of efficacy and safety findings by age from two phase three randomized controlled trials.

Pediatr Dermatol 2019 Jan 19;36(1):89-99. Epub 2018 Nov 19.

Eastern Virginia Medical School and Virginia Clinical Research, Inc., Norfolk, Virginia.

Objectives: Hyperhidrosis in pediatric patients has been understudied. Post hoc analyses of two phase 3 randomized, vehicle-controlled, 4-week trials (ATMOS-1 [NCT02530281] and ATMOS-2 [NCT02530294]) were performed to assess efficacy and safety of topical anticholinergic glycopyrronium tosylate (GT) in pediatric patients.

Methods: Patients had primary axillary hyperhidrosis ≥ 6 months, average Axillary Sweating Daily Diary (ASDD/ASDD-Children [ASDD-C]) Item 2 (sweating severity) score ≥ 4, sweat production ≥ 50 mg/5 min (each axilla), and Hyperhidrosis Disease Severity Scale (HDSS) ≥ 3. Read More

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http://dx.doi.org/10.1111/pde.13723DOI Listing
January 2019
10 Reads

Use of antipsychotic drugs in dermatology.

Clin Dermatol 2018 Nov - Dec;36(6):765-773. Epub 2018 Aug 16.

Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Antipsychotic drugs can be beneficial in dermatology because of their both central nervous system and peripheral effects. All antipsychotic drugs have a central postsynaptic dopamine D2 receptor blocking effect, which underlies their antipsychotic action. The antipsychotic drugs have varying degrees of histamine H1-receptor, cholinergic muscarinic receptor, and α1-adrenergic receptor blocking effects, which can affect cutaneous perception and the autonomic reactivity of the skin and can be potentially beneficial in the management of certain histamine or sympathetically mediated dermatologic manifestations (eg, urticaria, pruritus, hyperhidrosis). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0738081X183017
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http://dx.doi.org/10.1016/j.clindermatol.2018.08.006DOI Listing
August 2018
20 Reads

Use of antiepileptic mood stabilizers in dermatology.

Clin Dermatol 2018 Nov - Dec;36(6):756-764. Epub 2018 Aug 16.

Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Several antiepileptic drugs (AEDs) are approved by the US Food and Drug Administration for the treatment of bipolar disorder (valproic acid, divalproex, lamotrigine, carbamazepine) and some cutaneous neuropathic pain syndromes (carbamazepine, gabapentin, pregabalin). The AEDs may be effective in the management of (1) chronic pruritus, including pruritus due systemic disease, including uremia, neuropathic pain, neuropathic pruritus, and complex cutaneous sensory syndromes, especially where central nervous system (CNS) sensitization plays a role; (2) management of emotional dysregulation and the resultant repetitive self-excoriation or other cutaneous self-injury in patients who repetitively stimulate or manipulate their integument to regulate emotions (prurigo nodularis, lichen simplex chronicus, skin picking disorder, trichotillomania); (3) management of dermatologic clinical manifestations associated with autonomic nervous system activation (hyperhidrosis, urticaria, flushing; these often occur in conjunction with psychiatric disorders with prominent autonomic activation and dysregulation, eg, social anxiety disorder, posttraumatic stress disorder); and (4) when certain anticonvulsants have a direct therapeutic effect (eg, in psoriasis); currently the use of AEDs for such cases is largely experimental. Gabapentin (dosage range 300-3600 mg daily) is the most widely studied AED mood stabilizer in dermatology and is especially effective in situations where CNS sensitization is a mediating factor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0738081X183017
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http://dx.doi.org/10.1016/j.clindermatol.2018.08.005DOI Listing
August 2018
17 Reads

Comparative study of transepidermal water loss in patients with and without hyperhidrosis by closed-chamber measurer in an air-conditioned environment.

Einstein (Sao Paulo) 2018 Nov 8;16(4):eAO4312. Epub 2018 Nov 8.

Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Objective: To evaluate the difference in transepidermal water loss in patients diagnosed with hyperhidrosis and healthy subjects, in an air-conditioned environment.

Methods: Twenty patients diagnosed with hyperhidrosis and 20 healthy subjects were subjected to quantitative assessment using a closed-chamber device, in six previously established sites.

Results: The measurements showed different transepidermal water loss values for healthy subjects and patients with hyperhidrosis, especially in the hands and feet. Read More

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http://dx.doi.org/10.31744/einstein_journal/2018AO4312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223951PMC
November 2018

Shortening of Incision by "Pinch and Turn-Over Technique" in the Treatment of Axillary Osmidrosis.

Authors:
Eui-Tae Lee

Aesthetic Plast Surg 2019 Feb 9;43(1):267-277. Epub 2018 Nov 9.

Department of Plastic and Reconstructive Surgery, Chungbuk National University College of Medicine, 1, Chungdae-Ro, Seowon-gu, Cheongju, Chungbuk, 28644, Korea.

Background: The pinch and turn-over technique was developed to minimize the incision in the manual subdermal excision of apocrine glands in axillary osmidrosis for the best cure and fewest complications.

Methods: Through a 2-cm-long incision, peripheral subdermal tissue was excised by the technique under direct vision using intravenous anesthesia and tumescent technique. Ninety-nine axillae in 50 patients including seven secondary cases were operated on from 2009 to 2018. Read More

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http://link.springer.com/10.1007/s00266-018-1263-2
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http://dx.doi.org/10.1007/s00266-018-1263-2DOI Listing
February 2019
13 Reads

[The role of the combined balneotherapeutic treatment as the 'add-back therapy' against the background of the anti-hormonal effects of the agonists of gonadotropin-releasing hormone in the women suffering from endometriosis genitalis externa].

Vopr Kurortol Fizioter Lech Fiz Kult 2018 ;95(5):31-39

Pyatigorsk state scientific research institute of balneotherapeiutics, Russian Federal Medical Biological Agency, Pyatigorsk, Russia.

Background: The use of agonists of gonadotropin-releasing hormone (GnRH) for the rehabilitation treatment of the patients presenting with endometriosis genitalis externa is known to significantly enhance the risk of development of hypoestrogenism. The so-called 'add-back-therapy' is carried out as a preventive measure to eliminate hypoestrogenism caused by the intake of GnRH agonists without detriment to the effectiveness of anti-hormonal therapy.

Aim: The objective of the present study was to estimate the effectiveness of the new method ('add-back hormone replacement therapy') in comparison with anti-hormonal therapy with the use of GRH agonists at the stage of the early postoperative medical rehabilitation based on the drinking of mineral waters (MW) and radon therapy (RT) in the patients who had undergone the laparoscopic interventions for the treatment of endometrioid heterotopies of the ovaries (1-3 months post-operatively). Read More

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http://dx.doi.org/10.17116/kurort20189505131DOI Listing
January 2018
16 Reads

Simultaneous Pheochromocytoma, Paraganglioma, and Papillary Thyroid Carcinoma without Known Mutation.

Case Rep Endocrinol 2018 14;2018:6358485. Epub 2018 Oct 14.

Einstein Medical Center, 5501 Old York Rd., Philadelphia, PA 19141, USA.

Background: Pheochromocytoma/paraganglioma is a rare tumor from neuroendocrine cells. 1/3 of cases have germline mutations. Papillary thyroid carcinoma (PTC) is a common neoplasm from follicular cells of the thyroid. Read More

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https://www.hindawi.com/journals/crie/2018/6358485/
Publisher Site
http://dx.doi.org/10.1155/2018/6358485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204204PMC
October 2018
10 Reads

Sleep disorders and endothelial dysfunction in children with sickle cell anemia.

Sleep Med 2019 Jan 25;53:9-15. Epub 2018 Sep 25.

Department of Pediatrics, School of Medicine, Federal University of Bahia, Salvador, Bahia, 40080-002, Brazil. Electronic address:

Objective: We sought to assess sleep characteristics in children with sickle cell anemia (SCA) to investigate the possible association between sleep-related disorders and parameters of endothelial function.

Methods: Sleep Disturbance Scale for Children (SDSC) and endothelial function variables (flow-mediated dilatation using brachial artery ultrasound, cytokines) were compared in children with SCA and healthy children aged 6-18 years.

Results: Flow-mediated dilation (FMD) median (IQR) values were 10. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13899457183069
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http://dx.doi.org/10.1016/j.sleep.2018.08.019DOI Listing
January 2019
5 Reads

Changes in Palm Temperature as Predictor of Long-term Cure of Sympathicotomy for Palmar hyperhidrosis?

J Neurol Surg A Cent Eur Neurosurg 2018 Oct 31. Epub 2018 Oct 31.

Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

Objectives:  To investigate the long-term relationship between intraoperative temperature changes of the palm, treatment effects and compensatory hyperhidrosis (CH).

Methods:  We retrospectively analyzed the data of 41 patients with palmar hyperhidrosis who underwent bilateral endoscopic sympathicotomy 3 to 6 years ago. Before and after the operation, changes in ipsilateral palm temperature were monitored and recorded to evaluate the curative effect of the sympathicotomy. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1666790
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http://dx.doi.org/10.1055/s-0038-1666790DOI Listing
October 2018
11 Reads

Topical Glycopyrronium Tosylate for the Treatment of Primary Axillary Hyperhidrosis: Patient-Reported Outcomes from the ATMOS-1 and ATMOS-2 Phase III Randomized Controlled Trials.

Am J Clin Dermatol 2019 Feb;20(1):135-145

Saint Louis University, St. Louis, MO, USA.

Background: Glycopyrronium tosylate (GT) is a topical anticholinergic approved in the USA for primary axillary hyperhidrosis in patients aged ≥ 9 years. GT was evaluated for primary axillary hyperhidrosis in replicate, randomized, double-blind, vehicle-controlled, phase III trials. GT reduced sweating severity and production versus vehicle and was generally well tolerated. Read More

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http://link.springer.com/10.1007/s40257-018-0395-0
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http://dx.doi.org/10.1007/s40257-018-0395-0DOI Listing
February 2019
16 Reads

Genetic polymorphism analysis of patients with primary hyperhidrosis.

Clin Cosmet Investig Dermatol 2018 11;11:477-483. Epub 2018 Oct 11.

Alabama College of Osteopathic Medicine, Dothan, AL, USA,

Background: Hyperhidrosis affects 220 million people worldwide. The hallmark of this condition is excessive sweating, which negatively impacts the social, emotional, and occupational lives of these individuals. A familial predisposition has been established; however, the specific genes involved have yet to be identified. Read More

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https://www.dovepress.com/genetic-polymorphism-analysis-of-p
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http://dx.doi.org/10.2147/CCID.S176842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187922PMC
October 2018
8 Reads

Efficacy of a mandibular advancement intraoral appliance (MOA) for the treatment of obstructive sleep apnea syndrome (OSAS) in pediatric patients: A pilot-study.

Med Oral Patol Oral Cir Bucal 2018 Nov 1;23(6):e656-e663. Epub 2018 Nov 1.

Av. Ipiranga, 6681, 90619-900 Porto Alegre RS, Brazil,

Background: To evaluate the treatment efficacy of a mandibular advancement intraoral appliance (MOA) for treatment of obstructive sleep apnea syndrome (OSAS) in pediatric patients.

Material And Methods: Eighteen patients (mean=8.39 years old, women=44. Read More

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http://dx.doi.org/10.4317/medoral.22580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260994PMC
November 2018
2 Reads

Autonomic Disorders.

Authors:
Peter Novak

Am J Med 2018 Oct 9. Epub 2018 Oct 9.

Department of Neurology, Brigham and Women's Faulkner Hospital, Harvard Medical School, Boston, MA. Electronic address:

Autonomic complaints are frequently encountered in clinical practice. They can be due to primary autonomic disorders or secondary to other medical conditions. Primary autonomic disorders can be categorized as orthostatic intolerance syndromes and small fiber neuropathies; the latter are associated with autonomic failure, pain, or their combinations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029343183095
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http://dx.doi.org/10.1016/j.amjmed.2018.09.027DOI Listing
October 2018
30 Reads

A randomized, double-blind, placebo-controlled, crossover study to evaluate the human abuse liability of solriamfetol, a selective dopamine and norepinephrine reuptake inhibitor.

J Psychopharmacol 2018 Dec 1;32(12):1351-1361. Epub 2018 Oct 1.

6 Department of Pharmacology and Toxicology, Medicine, and Psychiatry, University of Toronto, ON, Canada.

Background:: This study evaluated the human abuse potential of solriamfetol (formerly JZP-110), a selective dopamine and norepinephrine reuptake inhibitor with robust wake-promoting effects.

Methods:: Adults with a recent history of recreational polydrug use, including stimulants, and who met criteria in a Qualification Phase were randomized to one of six sequences in a Test Phase. Each Test Phase sequence included a single administration of placebo, solriamfetol (300, 600, and 1200 mg), and phentermine (45 and 90 mg), with a two-day washout between periods. Read More

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http://dx.doi.org/10.1177/0269881118796814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247449PMC
December 2018
18 Reads

Relationship between depression scores and degree of skin perspiration: A novel cross-sectional study.

Int Wound J 2019 Feb 24;16(1):139-143. Epub 2018 Sep 24.

Nursing and Physical Therapy Department, Institute of Biomedicine (IBIOMED), Faculty of Health Sciences, Universidad de León, Ponferrada, León, Spain.

Primary hyperhidrosis (PH) is a common pathological condition related to excessive sweating. It may be associated with depression. Therefore, the main aim of this study was to analyse and compare depression scores between subjects without PH (degree-I) and patients with PH (degrees-II, -III, and -IV). Read More

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http://dx.doi.org/10.1111/iwj.13004DOI Listing
February 2019
8 Reads

Clinical evaluation of an antiperspirant for hyperhidrosis.

G Ital Dermatol Venereol 2018 Sep 20. Epub 2018 Sep 20.

Dipartimento di Bioscienze Mediche, Chirurgiche Ortopediche, IRCCS Ospedale Galeazzi, Università degli Studi di Milano, Milan, Italy.

Background: Hyperhidrosis is a fairly common condition characterized by excessive sweating, usually in axillary areas. Although not involving major health problems, it is a significant psychological distress to those affected, compromising their social life. The first line of defense used to address this problem are antiperspirants, usually containing aluminum salts, capable of blocking the excessive sweating. Read More

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http://dx.doi.org/10.23736/S0392-0488.18.05986-2DOI Listing
September 2018
2 Reads

No sweat: Favorable outcomes of hyperhidrosis surgery with age.

J Thorac Cardiovasc Surg 2018 Oct 2;156(4):1759-1760. Epub 2018 Aug 2.

Department of Surgery, Yale New Haven Hospital, Yale University, New Haven, Conn.

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http://dx.doi.org/10.1016/j.jtcvs.2018.07.055DOI Listing
October 2018
4 Reads

Percutaneous Radiofrequency Ablation for Hyperhidrosis: Ready for Primetime?

Semin Thorac Cardiovasc Surg 2018 15;30(3):367-368. Epub 2018 Sep 15.

Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1053/j.semtcvs.2018.09.008DOI Listing
December 2018

Interventional management of hyperhidrosis in secondary care: where do we go from here?

Authors:
A Durack

Br J Dermatol 2018 Sep;179(3):555-556

Department of Dermatology, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, U.K.

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http://dx.doi.org/10.1111/bjd.16940DOI Listing
September 2018

[Hyperhidrosis-aetiopathogenesis, diagnosis, clinical symptoms and treatment].

Authors:
J Wohlrab B Kreft

Hautarzt 2018 Oct;69(10):857-869

Universitätsklinik und Poliklinik für Dermatologie und Venerologie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle (Saale), Deutschland.

Although primary hyperhidrosis is a common disease, secondary symptomatic hyperhidrosis is rather rare. Primary hyperhidrosis is a complex neuropathic dysregulation with a genetic predisposition and is diagnosed when patients show pathologic sweating patterns and excessive sweating for at least 6 months and fulfill at least four of the following criteria: affected areas are axillae and/or palms and/or soles and/or forehead; symmetry; no night sweating; at least once a week; onset before the age of 25; positive family history; negative impact on daily activities. Frequently used therapies are topical aluminum salts and anticholinergics, iontophoresis in water, and intracutaneous botulinum toxin. Read More

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http://dx.doi.org/10.1007/s00105-018-4265-8DOI Listing
October 2018

CT-Guided Chemical Thoracic Sympathectomy versus Botulinum Toxin Type A Injection for Palmar Hyperhidrosis.

Thorac Cardiovasc Surg 2018 Sep 14. Epub 2018 Sep 14.

Department of Plastic Surgery, General Hospital of Guangzhou Military Command of PLA, Guangzhou, Guangdong, People's Republic of China.

Background:  The present study aimed to evaluate and compare the efficacy of botulinum toxin type A (BTX-A) injection versus thoracic sympathectomy for idiopathic palmar hyperhidrosis.

Methods:  Fifty-one patients with idiopathic palmar hyperhidrosis were treated with either BTX-A injection or thoracic sympathectomy between March 2013 and April 2016. The severity of palmar hyperhidrosis was qualitatively measured via the Hyperhidrosis Disease Severity Scale (HDSS). Read More

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http://dx.doi.org/10.1055/s-0038-1668599DOI Listing
September 2018
7 Reads