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    Versajet-Assisted Hydraulic Epilation Through Small Incisions for Axillary Osmidrosis.
    Aesthetic Plast Surg 2018 Feb 20. Epub 2018 Feb 20.
    Department of Plastic and Reconstructive Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, 03181, Republic of Korea.
    Background: Osmidrosis is a malodorous disease caused by the breakdown of sweat secreted from the apocrine glands by surface bacteria. The aim of this study was to evaluate the effect of Versajet-assisted hydraulic epilation for the treatment of axillary osmidrosis.

    Methods: Thirty-two patients with axillary osmidrosis (64 axillae) underwent Versajet-assisted hydraulic epilation between January 2016 and January 2017. Read More

    Generalized hyperhidrosis secondary to presumed eccrine gland dysfunction with possible apocrine metaplasia.
    Dermatol Online J 2017 Dec 15;23(12). Epub 2017 Dec 15.
    New York University Health, New York.
    We present a 57 year-old man presented with generalized hyperhidrosis and widespread, smooth, flesh colored papules on the torso and extremities.Histological examination from multiple biopsies demonstrated morphologic alteration of the eccrine glands with an apocrine phenotype, suggesting eitherapocrine metaplasia or the presence of "apoeccrine glands." The morphologic similarities between eccrine, apocrine, and apoeccrine as they relate to ourpatient's histologic findings are discussed. Read More

    Extended uniportal bilateral sympathectomy.
    J Vis Surg 2018 30;4:27. Epub 2018 Jan 30.
    Section of Thoracic Surgery, Department of General and Medical Specialties, Policlinico University Hospital of Catania, University of Catania, Catania, Italy.
    Hyperhidrosis affect 3% of the population and, despite benign nature of the disease, the individuals seek medical advice in order to improve their quality of life which can be severely compromised. The interruption of the sympathetic chain (sympathectomy) and of the nerve of Kuntz established its role as the definitive treatment of primary hyperhidrosis. In this manuscript, we present our extended uniportal technique with the aid of the video. Read More

    The First Reported Case of Fibrous Hamartoma of Infancy with Hyperhidrosis and Hypertrichosis in Korea.
    J Korean Med Sci 2018 Feb 26;33(9):e66. Epub 2018 Feb 26.
    Department of Dermatology, Yeungnam University College of Medicine, Daegu, Korea.
    Fibrous hamartoma of infancy (FHI) is a rare entity with a benign nature. The typical clinical features are a single, slowly growing, painless mass on the trunk that appears within the first 2 years of life. We report a 13-month-old boy who presented with a plaque on the lower back since 4 months of age. Read More

    Alternative Surgical Methods in Patients with Recurrent Palmar Hyperhidrosis and Compensatory Hyperhidrosis.
    Yonsei Med J 2018 Mar;59(2):345-348
    Department of Thoracic and Cardiovascular Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
    Recurrent hyperhidrosis after thoracic sympathectomy is an uncomfortable condition, and compensatory hyperhidrosis (CH) is one of the most troublesome side effects. Here, we describe two patients with recurrent palmar hyperhidrosis (PH) and CH over the whole body simultaneously. They were treated with bilateral T4 sympathetic clipping and reconstruction of the sympathetic nerve from a T5 to T8 sympathetic nerve graft, which was transferred to the resected T3 sympathetic bed site. Read More

    Focal facial hyperhidrosis associated with internal carotid artery dissection successfully treated with botulinum toxin A.
    J Eur Acad Dermatol Venereol 2018 Feb 11. Epub 2018 Feb 11.
    Dermatology department, Paul Sabatier University, Toulouse University Hospital.
    Hyperhidrosis affects up to 3% of the population. Secondary hyperhidrosis may be associated with infections, malignancies, endocrine or neurological diseases. We report the first case of localized hyperhidrosis associated to Pourfour du Petit syndrome secondary to internal carotid artery dissection successfully and safely treated with botulinum toxin. Read More

    Inguinal Hyperhidrosis: Case Report of an Uncommon Cause of Vaginitis.
    J Pediatr Adolesc Gynecol 2018 Feb 5. Epub 2018 Feb 5.
    Division of Pediatric and Adolescent Gynecology, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX.
    Background: Hyperhidrosis (excessive sweating) affects 1-3% of the population. Primary focal hyperhidrosis most commonly affects the axilla, palms, and soles. There are few case reports of hyperhidrosis of the genital region, typically described as inguinal hyperhidrosis or Hexsel's hyperhidrosis. Read More

    Two patients with localised hyperhidrosis of the hand based on functional and structural abnormalities of sweat glands.
    BMJ Case Rep 2018 Jan 31;2018. Epub 2018 Jan 31.
    Dermatology and Allergy Center, University Hospital of Odense, Odense, Denmark.
    A 14-year-old girl and a 30-year-old woman presented with localised hyperhidrosis on the dorsal hand and wrist, respectively, provoked by different stimuli such as physical activity and minor trauma to the skin. The skin was seemingly normal in both patients where an iodine-starch test revealed a well-demarcated area of hyperhidrosis. Following histopathological examination, the diagnosis was unilateral localised hyperhidrosis in both cases; one with normal histology and one with a nevus sudoriferous. Read More

    Severe dysautonomia as a main feature of anti-GAD encephalitis: Report of a paediatric case and literature review.
    Eur J Paediatr Neurol 2018 Jan 12. Epub 2018 Jan 12.
    Research Unit UR12 SP24 and Department of Child and Adolescent Neurology, National Institute Mongi Ben Hmida of Neurology, Tunis, Tunisia; Université de Tunis El Manar, Faculté de Médecine de Tunis, 1007, Tunis, Tunisia.
    Introduction: Anti-glutamic acid decarboxylase (anti-GAD65) antibodies are a rare cause of autoimmune encephalitis. This entity is mainly recognized in adults and very few cases were reported in children. We report on a paediatric case of anti-GAD encephalitis with severe presentation and uncontrollable dysautonomia. Read More

    Oxybutynin 3% gel for the treatment of primary focal hyperhidrosis in adolescents and young adults.
    Pediatr Dermatol 2018 Jan 15. Epub 2018 Jan 15.
    Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO, USA.
    Background/objectives: There are no reliably effective, well-tolerated topical agents for the treatment of hyperhidrosis. We sought to evaluate the efficacy and tolerability of oxybutynin 3% gel in adolescents and young adults with primary focal hyperhidrosis.

    Methods: Patients with severe axillary hyperhidrosis were treated with topical oxybutynin 3% gel for 4 weeks. Read More

    Laser treatment of primary axillary hyperhidrosis: a review of the literature.
    Lasers Med Sci 2018 Jan 11. Epub 2018 Jan 11.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave., Miami, FL, 33136, USA.
    Hyperhidrosis o`ccurs when the body produces sweat beyond what is essential to maintain thermal homeostasis. The condition tends to occur in areas marked by high-eccrine density such as the axillae, palms, and soles and less commonly in the craniofacial area. The current standard of care is topical aluminum chloride hexahydrate antiperspirant (10-20%), but other treatments such as anticholinergics, clonidine, propranolol, antiadrenergics, injections with attenuated botulinum toxin, microwave technology, and surgery have been therapeutically implicated as well. Read More

    Granulosis Rubra Nasi Response to Topical Tacrolimus.
    Case Rep Dermatol Med 2017 29;2017:2519814. Epub 2017 Nov 29.
    Department of Dermatology, Venereology & Leprosy, Jawaharlal Nehru Medical College and KLE's Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum, Karnataka 590 010, India.
    Granulosis Rubra Nasi (GRN) is a rare disorder of the eccrine glands. It is clinically characterized by hyperhidrosis of the central part of the face, most commonly on the tip of the nose, followed by appearance of diffuse erythema over the nose, cheeks, chin, and upper lip. It is commonly seen in childhood but it can present in adults. Read More

    Evaluation of topical liposome incorporated clove oil in the treatment of idiopathic palmar hyperhidrosis: Single-blinded placebo-controlled study.
    J Cosmet Dermatol 2017 Dec 28. Epub 2017 Dec 28.
    Department of Dermatology and Venerology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
    Introduction: Palmar hyperhidrosis is of great concern to patients because of its physical, occupational, and psychological impact on quality of life. Topical clove oil has been used in many conditions due to its major component Eugenol that exerts blocking effect on nerve transmission.

    Aim Of The Work: To assess the efficacy of topical liposome incorporated clove oil in decreasing the rate of sweating among patients with idiopathic palmar hyperhidrosis. Read More

    Synchronous bilateral pheochromocytomas and paraganglioma with novel germline mutation in MAX: a case report.
    Surg Case Rep 2017 Dec 28;3(1):131. Epub 2017 Dec 28.
    Department of Breast and Endocrine Surgery (Surgery II), Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
    Background: Recent advance of genetic testing has contributed to the diagnosis of hereditary pheochromocytoma and paraganglioma (PPGL). The clinical characteristics of hereditary PPGL are varying among the types of mutational genes. It is still difficult to specify the pathognomonic symptoms in the case of rare genetic mutations. Read More

    [Prevention and treatment of Horner syndrome in treatment of head and face hyperhidrosis by thoracic sympathetic nerve modulation].
    Zhonghua Yi Xue Za Zhi 2017 Dec;97(46):3624-3627
    Bengbu Medical College Graduate Department, Bengbu 233030, China.
    By summarize the Prevention and Treatment of Horner Syndrome of CT-guided thoracic sympathetic nerve modulation in the treatment of head and face Hyperhidrosis, reduce the occurrence of the complications.A retrospective analysis was made on 116 patients of CT-guided thoracic sympathetic nerve modulation in the treatment of head and face Hyperhidrosis in The First Hospital of Jiaxing from January 2010 to December 2016. Analysis the reasons of Horner syndrome and external management to sum up the corresponding prevention and treatment measures. Read More

    Interventions for hyperhidrosis in secondary care: a systematic review and value-of-information analysis.
    Health Technol Assess 2017 Dec;21(80):1-280
    Centre for Reviews and Dissemination, University of York, York, UK.
    Background: Hyperhidrosis is uncontrollable excessive sweating that occurs at rest, regardless of temperature. The symptoms of hyperhidrosis can significantly affect quality of life. The management of hyperhidrosis is uncertain and variable. Read More

    [Application of functional parotidectomy via retroauricular hairline incision in the excising superficial parotid tumor].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Dec;52(12):905-908
    Department of Otorhinolaryngology Head and Neck Surgery, University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China;Division of Otorhinolaryngology Head and Neck Surgery, Department of Surgery, University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong 999077, China.
    To evaluate the usefulness of retroauricular hairline incision (RAHI) in partial superficial parotidectomy (PSP) by comparison with modified Blair incision (MBI).A retrospective analysis of 64 medical records for patients with benign parotid tumors who underwent partial superficial parotidectomy was undertaken (28 were in MBI group, 36 in RAHI group). Size and location of tumors, operative time, occurrence of facial nerve paralysis and Frey's syndrome, and cosmetic outcomes were compared between RAHI and MBI groups. Read More

    The therapeutic effect of modified Huangqi Guizhi Wuwu Tang for multiple myeloma: An 18-year follow-up case report.
    Medicine (Baltimore) 2017 Dec;96(49):e9074
    aBasic Medicine CollegebInternational Jingfang Institute, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
    Rationale: Multiple myeloma (MM) is a hematologic malignancy characterized by proliferation of clonal plasma cells in the bone marrow. The median survival has increased to 6 years in recent years. But MM remains incurable. Read More

    Postmenopausal craniofacial hyperhidrosis.
    Clin Exp Dermatol 2018 Mar 13;43(2):180-182. Epub 2017 Dec 13.
    Department of Dermatology, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Broadgreen Hospital, Liverpool, UK.
    Hyperhidrosis is a condition marked by excessive sweating, which can either be localized or generalized. Primary focal hyperhidrosis (PFH) can arise from the palms, plantar feet, axillae and also from the face and scalp. PFH primarily affects a younger population of children and young adults, with the majority presenting before the age of 25 years. Read More

    Antidiabetic and Lipid-Lowering Effects of the Polyphenol Extracts from the Leaves of Clausena lansium (Lour.) Skeels on Streptozotocin-Induced Type 2 Diabetic Rats.
    J Food Sci 2018 Jan 11;83(1):212-220. Epub 2017 Dec 11.
    Coll. of Pharmacy, Guangdong Pharmaceutical Univ., Guangzhou 510006, China.
    Clausena lansium (Lour.) Skeels (Wampee) is widely grown in China and considered as a healthy fruit. Its leaves are also considered as traditional herbs. Read More

    Is compensatory hyperhidrosis after thoracic sympathicotomy in palmar hyperhidrosis patients related to the excitability of thoracic sympathetic ganglions?
    J Thorac Dis 2017 Sep;9(9):3069-3075
    Department of Thoracic Surgery, Xiamen Hospital of Traditional Chinese Medicine, Xiamen 361000, China.
    Background: The mechanism of compensatory hyperhidrosis remains unclear. The aim of this study was to explore the relationship between compensatory hyperhidrosis and thoracic sympathetic ganglion excitability to assess the effectiveness of thoracoscopic T4 sympathicotomy for treating palmar hyperhidrosis.

    Methods: Sixty-six cases of T4 sympathetic ganglions were prospectively collected from patients with palmar hyperhidrosis who underwent thoracoscopic T4 sympathicotomy from 2013 to 2016 in our department. Read More

    Survival study of treatment adherence by patients given oral oxibutynin for hyperhidrosis.
    J Eur Acad Dermatol Venereol 2017 Dec 8. Epub 2017 Dec 8.
    Dermatology Department, Hospital Costa del Sol, Marbella, Málaga, Spain.
    Introduction: In recent years, increasing use has been made of oral anticholinergics such as oxybutynin for the management of hyperhidrosis. The primary aim of this study is to determine the variables associated with adherence to this treatment, and secondarily to obtain data on its effectiveness, safety and adverse effects.

    Material And Methods: This is a prospective study of patients with hyperhidrosis, at any location, receiving treatment with oral oxybutynin in the period 2007-2016. Read More

    Polyarthritis is a Rare Manifestation of Pachydermoperiostosis: A Case Report.
    Mymensingh Med J 2017 Oct;26(4):939-943
    Dr Md Faysal Ahmmed, Resident, Department of Rheumatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
    Pachydermoperiostosis or primary hypertrophic osteoarthropathy, also known as Touraine-Solente-Gole syndrome, is a rare process, frequently inherited. In its complete form it is characterized by pachydermia (thickening of the skin), skeletal changes (periostosis) and acropachia (digital clubbing). Diagnosis can be made considering the typical clinical features and the histological feature. Read More

    Pulsed radiofrequency stimulation suppresses palmar hyperhidrosis in an animal study.
    Brain Behav 2017 Nov 26;7(11):e00833. Epub 2017 Sep 26.
    Department of Veterinary MedicineSchool of Veterinary MedicineNational Taiwan UniversityTaipeiTaiwan.
    Objectives: Palmar hyperhidrosis (PH) exhibits excessive and unpredictable sweating. The most effective treatment for permanent cure is the ablation of thoracic sympathetic ganglia innervating hands. However, sympathectomy of T2 sympathetic ganglion by clipping or cauterization causes irreversible nerve damage, and results in a compensatory hyperhidrosis (CH). Read More

    Treatment of Palmar Hyperhidrosis with Tap Water Iontophoresis: A Randomized, Sham-Controlled, Single-Blind, and Parallel-Designed Clinical Trial.
    Ann Dermatol 2017 Dec 30;29(6):728-734. Epub 2017 Oct 30.
    Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, Korea.
    Background: Palmar hyperhidrosis is a common disorder of excessive sweating. A number of studies have demonstrated the effectiveness of iontophoresis in the treatment of palmar hyperhidrosis. However, controlled clinical studies on iontophoresis for palmar hyperhidrosis have been limited. Read More

    [Aripiprazole-Induced Hyperhidrosis: Two Case Reports].
    Turk Psikiyatri Derg 2017 ;28(2):132-134
    Many drugs including anti-depressants and anti-psychotics are known to cause excessive sweating (hyperhidrosis). Hyperhidrosis may be caused by drugs acting at the hypothalamus, spinal thermoregulatory centres, and sympathetic ganglia or at the eccrine-neuroeffector junction. Hyperhidrosis can be distressing and embarrassing symptom, which if not addressed properly, may lead to non-concordance to medication. Read More

    Dermatologic manifestations of endocrine disorders.
    Transl Pediatr 2017 Oct;6(4):300-312
    The Ohio State University College of Medicine, Columbus, OH, USA.
    The skin serves as a window for clinicians to understand, diagnose, and monitor endocrine disease. Dermatologic manifestations of endocrinopathies contribute significantly to an individual's health and quality of life. In this review, we outline various disorders of the hypothalamic-pituitary axis, thyroid gland, pancreas, adrenal gland, and androgen axis as well as hereditary endocrine syndromes. Read More

    Phase IIIb safety results from an expanded-access protocol of talimogene laherparepvec for patients with unresected, stage IIIB-IVM1c melanoma.
    Melanoma Res 2018 Feb;28(1):44-51
    Department of Hematology and Oncology, Minnesota Oncology, Fridley, Minnesota.
    Talimogene laherparepvec is a genetically modified herpes simplex virus-1-based oncolytic immunotherapy for the local treatment of unresectable cutaneous, subcutaneous, and nodal tumors in patients with melanoma recurrence following surgery. We aim to describe the safety of talimogene laherparepvec. Intralesional talimogene laherparepvec was administered at less than or equal to 4 ml×10 PFU/ml at protocol day 1, then less than or equal to 4 ml×10 PFU/ml 21 days later, and then every 14 days. Read More

    [Palmar and axillary hyperhidrosis in children: endoscopic thoracic sympathectomy using clips for an underestimated problem].
    Ned Tijdschr Geneeskd 2017 ;161(0):D1615
    Albert Schweitzer ziekenhuis, Dordrecht.
    Background: Palmar and axillary hyperhidrosis are defined as perspiration exceeding the body's 'normal' physiological need for thermal regulation. This condition affects about 1% of adolescents and children and may lead to psychosocial problems and poor school performance.

    Case Description: We carried out an endoscopic thoracic sympathectomy (ETS) with clips in a 14-year-old girl and a 16-year-old girl who suffered from debilitating palmar and axillary hyperhidrosis. Read More

    Retroperitoneoscopic lumbar sympathectomy for plantar hyperhidrosis.
    J Vasc Surg 2017 Dec;66(6):1806-1813
    Department of Medicine, Universidade Tiradentes, Aracaju, Sergipe, Brazil.
    Objective: The objective of this study was to assess the reduction in quality of life (QoL) caused by the persistence of primary plantar hyperhidrosis (PPH) symptoms and the level of satisfaction in PPH patients after retroperitoneoscopic lumbar sympathectomy (RLS). The efficacy, safety, and procedure of bilateral RLS in both sexes are also described in this study.

    Methods: This is a longitudinal study of consecutive patients who sought specific treatment from a private practitioner for severe PPH as classified on the Hyperhidrosis Disease Severity Scale (HDSS) from October 2005 to October 2014. Read More

    Epidemiologic analysis of prevalence of the hyperhidrosis.
    An Bras Dermatol 2017 Sep-Oct;92(5):630-634
    Department of Surgery - Division of Vascular and Endovascular Surgery of the Clinics Hospital of the School of Medicine of the Universidade de São Paulo (HCFMUSP) - São Paulo (SP), Brazil.
    Background: The present paper aims to study the prevalence of the various manifestations of hyperhidrosis in patients who sought treatment in a specialized ambulatory in the state of São Paulo.

    Objectives: Opposite to previous studies, this paper studies the different combinations of sweating sites, not being restricted to the main complaint site of the patients, but taking into consideration secondary complaints patients may present.

    Methods: This was a retrospective approach of a database containing more than 1200 patients in which were mapped: combination of sweating sites, age of onset, age spectrum, mean age, body mass index and gender of patients. Read More

    Physiological and pathophysiological firing properties of single postganglionic sympathetic neurons in humans.
    J Neurophysiol 2017 Nov 15:jn000042017. Epub 2017 Nov 15.
    2 University of Gothenburg.
    It has long been known from microneurographic recordings in human subjects that activity of postganglionic sympathetic axons occurs as spontaneous bursts, with muscle sympathetic nerve activity (MSNA) exhibiting strong cardiac rhythmicity via the baroreflex and skin sympathetic nerve activity (SSNA) showing much weaker cardiac modulation. Here we review the firing properties of single sympathetic neurons, obtained using highly selective microelectrodes. Individual vasoconstrictor neurons supplying muscle or skin, or sudomotor neurones supplying sweat glands, always discharge with a low firing probability (~30%) and at very low frequencies (~0. Read More

    Postoperative Harlequin Syndrome: Case Report of a Rare but Clinically Striking Condition.
    A A Case Rep 2017 Nov 9. Epub 2017 Nov 9.
    From the Departments of *Anesthesiology, †Pediatric Anesthesiology, and ‡Pediatric General Surgery, New York Medical College at Westchester Medical Center, Valhalla, New York.
    We present a case of a 2-year-old boy who underwent thoracoscopic resection of a left paraspinal mediastinal mass and developed Harlequin syndrome postoperatively. Harlequin syndrome is a rare neurological condition characterized by unilateral hyperhidrosis and erythema of the head and neck. Our discussion highlights this condition and other differential diagnoses that may present similarly in the postoperative period. Read More

    Prolonged and localized sweat stimulation by iontophoretic delivery of the slowly-metabolized cholinergic agent carbachol.
    J Dermatol Sci 2018 Jan 8;89(1):40-51. Epub 2017 Nov 8.
    Department of Electrical Engineering and Computing Science, University of Cincinnati, Cincinnati, Ohio 45221, USA.
    Background: Continuous non-invasive sampling and sensing of multiple classes of analytes could revolutionize medical diagnostics and wearable technologies, but also remains highly elusive because of the many confounding factors for candidate biofluids such as interstitial fluid, tears, saliva, and sweat. Eccrine sweat biosensing has seen a recent surge in demonstrations of wearable sampling and sensing devices. However, for subjects at rest, access to eccrine sweat is highly limited and unpredictable compared to saliva and tears. Read More

    [Axillary and perimamillary Fox-Fordyce disease (apocrine miliaria) in a 19-year-old woman].
    Hautarzt 2017 Nov 6. Epub 2017 Nov 6.
    Universitäts-Hautklinik Heidelberg, Ruprecht-Karls Universität Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland.
    Fox-Fordyce disease (FFD), also known as apocrine miliaria, is a rare and chronic skin disease characterized by itching and skin-colored, light brown or yellowish papules. FFD typically affects postpubertal young women between 13 and 35 years. The etiology is not completely known, but a hormonal component is in discussion. Read More

    Oxycodone/Naloxone Prolonged Release: A Review in Severe Chronic Pain.
    Clin Drug Investig 2017 Dec;37(12):1191-1201
    Springer, Private Bag 65901, Mairangi Bay, 0754, Auckland, New Zealand.
    Oral oxycodone/naloxone prolonged release (PR) [Targin, Targinact, Targiniq] is a 12-hourly opioid receptor agonist and opioid receptor antagonist fixed-dose combination product that is approved in countries in the EU for the management of severe pain (adequately manageable only with opioid analgesics) in adults. Oral naloxone prevents oxycodone from binding to μ-receptors in the gastrointestinal (GI) tract, thereby counteracting opioid-induced constipation (OIC). In short-term (5- to 12-week) clinical trials of adults with moderate to severe, chronic pain and OIC (OXN3001, OXN3006, OXN3506), oxycodone/naloxone PR significantly improved OIC while providing noninferior analgesia relative to oxycodone PR; results were consistent between cancer and non-cancer patients in OXN3506. Read More

    THE NON-NEURONAL AND NON-MUSCULAR EFFECTS OF BOTULINUM TOXIN: A Graceful Opportunity for a Deadly Molecule to Treat a Human Disease in the Skin and Beyond.
    Br J Dermatol 2017 Oct 31. Epub 2017 Oct 31.
    Department of Dermatology, University of California, Irvine, CA, USA.
    There is growing evidence that botulinum neurotoxins (BoNTs) exhibit biological effects on various human cell types with a host of associated clinical implications. The BoNT receptors and intracellular targets are not unique for neurotransmission. They have been found in both neuronal and non-neuronal cells, but there are differences in the way BoNT binds to, and acts on neuronal vs. Read More

    Neurophysiological Measures of Efficacy and Safety for Botulinum Toxin Injection in Facial and Bulbar Muscles: Special Considerations.
    Toxins (Basel) 2017 Oct 30;9(11). Epub 2017 Oct 30.
    Department of Neuroscience, Clinical Neurophysiology, Uppsala University, 75185 Uppsala, Sweden.
    Botulinum toxin (BoNT) injections into facial and bulbar muscles are widely and increasingly used as medical treatments for cervical and facial dystonia, facial hemispasm, correction of facial palsy, hyperhidrosis, as well as cosmetic treatment of glabellar lines associated with grief and anger. Although BoNT treatment is generally considered safe, the diffusion of the toxin to surrounding muscles may result in complications, including difficulties swallowing, in a dose-dependent manner. The sensitivity of clinical examination for detecting adverse events after BoNT treatment is limited. Read More

    Acupuncture and Cutaneous Medicine: Is It Effective?
    Med Acupunct 2017 Oct;29(5):269-275
    Medical Acupuncture of Chester County, West Chester, PA.
    In China, acupuncture has been used as a form of medical therapy for more than 2500 years. It is a part of traditional medical practice and is used to treat the entire spectrum of human and veterinary disease. Although dermatologic disease has received much less attention in worldwide acupuncture research than pain and musculoskeletal conditions, there is a growing body of evidence suggesting acupuncture's usefulness in this area. Read More

    Lasers and Energy-Based Devices in Men.
    Dermatol Surg 2017 Nov;43 Suppl 2:S176-S184
    *Department of Dermatology, University of California, Davis, Sacramento, California; †Laser and Skin Surgery Center of Northern California, Sacramento, California; ‡Laser and Dermatologic Surgery Center, Chesterfield, Missouri.
    Background: The demand for cosmetic treatments with lasers and energy-based devices has increased among men, but there is a dearth of literature that addresses the approach and treatment of cosmetic male patients.

    Objective: To summarize common cosmetic concerns for which male patients seek cosmetic treatments and to provide sex-specific recommendations for the lasers and energy-based devices that can be used for treatment.

    Materials And Methods: The authors conducted a literature search using the PubMed/MEDLINE and Google Scholar databases using the search terms male, men, gender, and cosmetic dermatology. Read More

    A phase 2a randomized controlled study to evaluate the pharmacokinetic, safety, tolerability and clinical effect of topically applied Umeclidinium in subjects with primary axillary hyperhidrosis.
    J Eur Acad Dermatol Venereol 2018 Jan 7;32(1):145-151. Epub 2017 Nov 7.
    Dermatology Therapeutic Area Unit, GlaxoSmithKline, Collegeville, PA, USA.
    Background: Hyperhidrosis is a common medical condition which can have a significant impact on quality of life. Umeclidinium (UMEC) is a long-acting muscarinic antagonist (LAMA) developed as a dermal formulation.

    Objectives: This 2-week, double-blind, randomized, vehicle-controlled study evaluated systemic exposure, safety and tolerability of topically administered UMEC in subjects with primary axillary hyperhidrosis. Read More

    Evaluation of patients who underwent resympathectomy for treatment of primary hyperhidrosis.
    Interact Cardiovasc Thorac Surg 2017 Nov;25(5):716-719
    Hospital Israelita Albert Einstein, São Paulo, Brazil.
    Objectives: Video thoracoscopic sympathectomy is the recommended surgical treatment for primary hyperhidrosis and has a high success rate. Despite this high success rate, some patients are unresponsive and eventually need a resympathectomy. Few studies have previously analysed exclusively the results of these resympathectomies in patients with primary hyperhidrosis. Read More

    Sialocutaneous fistula to the external auditory canal repaired with superficial parotidectomy and temporoparietal flap: A case report.
    Medicine (Baltimore) 2017 Oct;96(42):e7038
    Department of Otolaryngology-Head and Neck Surgery, Western University, London, ON, Canada.
    Rationale: Gustatory otorrhea can lead to cutaneous changes, recurrent infection, and social disruption. We present a case of a late, evolving sialocutaneous fistula to the external auditory canal, managed surgically after failing conservative therapies. This case is unique by late evolution, whereby the symptoms presented with significance 27 years after her operation and 19 years after mild symptoms initially arose. Read More

    CT-Guided, Percutaneous Ethanol Sympatholysis for Primary Hyperhidrosis.
    Cardiovasc Intervent Radiol 2018 Mar 16;41(3):477-482. Epub 2017 Oct 16.
    Division of Vascular and Interventional Radiology, The Johns Hopkins University School of Medicine, 1800 Orleans Street, Zayed 4th Flr, Baltimore, MD, 21287, USA.
    Purpose: Primary hyperhidrosis (PH) typically involves the craniofacial (CF) or axillary-palmar (AP) region. Our purpose was to determine the safety and efficacy of CT-guided sympatholysis for treating PH.

    Methods: In this prospective study, 39 consecutive patients with CF or AP PH were referred for percutaneous sympatholysis. Read More

    [Modern non-cosmetic treatment with botulinum toxins].
    Internist (Berl) 2017 Dec;58(12):1332-1340
    Neurologische Klinik und Poliklinik, Klinikum der Universität, LMU München, Marchioninistr. 15, 81377, München, Deutschland.
    Botulinum toxin has been known in medical history for a long time. The first scientific investigations and thoughts on possible indications in the treatment of muscular disorders were published by the German physician and poet Justinus Kerner in 1822. The physiological effect of botulinum toxin was identified in the middle of the twentieth century and the first clinical use was reported in 1977. Read More

    Evaluation of the quality of life of patients with primary hyperhidrosis submitted to videothoracoscopic sympathectomy.
    Rev Col Bras Cir 2017 Jul-Aug;44(4):323-327
    Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Departamento de Cirurgia Geral e Especializada, Mestrado Profissional em Técnicas Videoendoscópicas, Rio de Janeiro, RJ, Brasil.
    Objective: to evaluate the quality of life of patients undergoing video-assisted thoracoscopy for primary hyperhidrosis.

    Methods: we evaluated the patients who underwent thoracoscopic sympathectomy to treat primary hyperhidrosis by the team of thoracic surgery at the University Hospital Gaffrée and Guinle - UNIRIO between July 2004 and August 2013. It was applied a questionnaire about quality of life related to hyperhidrosis since preoperative period until one year after the surgery. Read More

    Epidemiology of hyperhidrosis in 2 population-based health care databases.
    J Am Acad Dermatol 2018 Feb 6;78(2):358-362. Epub 2017 Oct 6.
    Epidemiology Associates, LLC, Chapel Hill, North Carolina.
    Background: Population-based and clinical case reports of hyperhidrosis (HH) provide prevalence estimates that vary widely across reported studies because of differences in case ascertainment.

    Objective: In this study, we specify diagnostic, symptom, and prescription codes for HH to estimate incidence and prevalence for the United Kingdom and the United States.

    Methods: Data from UK and US health care databases were analyzed to ascertain HH cases and estimate incidence and prevalence from health care records during calendar years 2011 through 2013. Read More

    T3 versus T4 thoracoscopic sympathectomy for palmar hyperhidrosis: a meta-analysis and systematic review.
    J Surg Res 2017 Oct 15;218:124-131. Epub 2017 Jun 15.
    Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China. Electronic address:
    Background: Palmar hyperhidrosis (PH) is a benign sympathetic disorder that can adversely affect the quality of life of patients. Thoracic sympathectomy (TS) at the T3 or T4 level has been used to treat PH. We aimed to determine the optimal denervation level for TS by comparing the efficacy of T3 TS versus T4 TS in PH patients. Read More

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