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    5181 results match your criteria Hypereosinophilic Syndrome

    1 OF 104

    A Case of Loeffler Endocarditis That Showed Endomyocardial Systolic Dysfunction Detected by Layer Specific Strain Analysis.
    Int Heart J 2017 Nov 17. Epub 2017 Nov 17.
    Department of Cardiovascular Ultrasound, The First Hospital of China Medical University.
    Loeffler endocarditis is a rare comprehensive cardiac manifestation caused by eosinophilic cell infiltrations and is present in 50%-60% of patients with hypereosinophilic syndrome (HES). Left ventricle (LV) endocardial systolic dysfunction is a major cause of morbidity and mortality in HES and Loeffler endocarditis. We present a case of Loeffler endocarditis, whose left ventricular (LV) systolic dysfunction and endocardial systolic dysfunction were first neglected by conventional transthoracic echocardiography (TTE), but were later pointed out by layer-specific longitudinal strain analysis. Read More

    Biologic Agents for the Treatment of Hypereosinophilic Syndromes.
    J Allergy Clin Immunol Pract 2017 Nov - Dec;5(6):1502-1509
    Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Md. Electronic address:
    Hypereosinophilic syndromes (HES) are a heterogeneous group of rare disorders defined by the presence of marked peripheral or tissue eosinophilia resulting in end-organ damage. Although conventional therapies, including glucocorticoids, hydroxyurea, and IFN-α, are initially effective in reducing eosinophilia and symptoms in a majority of patients with platelet-derived growth factor mutation-negative HES, the development of resistance and treatment-related toxicity are common. In contrast, targeted therapy with the tyrosine kinase inhibitor, imatinib, is well tolerated but effective only in the subset of patients with HES with a primary myeloid disorder. Read More

    Idiopathic hypereosinophilia is clonal disorder? Clonality identified by targeted sequencing.
    PLoS One 2017 31;12(10):e0185602. Epub 2017 Oct 31.
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
    Idiopathic hypereosinophilia (IHE)/idiopathic hypereosinophilic syndrome (IHES) has been defined by a persistent elevation of the blood eosinophil count exceeding 1.5×103/μL, without evidence of reactive or clonal causes. While T-cell clonality assessment has been recommended for unexplained hypereosinophilia, this approach is not often applied to routine practice in the clinic. Read More

    Eosinophilic Lung Disease.
    Am J Med Sci 2017 Oct 15;354(4):339-349. Epub 2017 Mar 15.
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:
    Eosinophils are involved in the pathogenesis of a number of lung diseases. Recent advances in eosinophil biology have now produced clinically applicable therapies that seek to counter eosinophilia in blood and lungs. This article reviews the basic biology of eosinophils and their role in mediating T-helper 2 cell responses. Read More

    [Pediatric idiopathic hypereosinophilic syndrome with pulmonary embolism: a case report and review of literature].
    Zhonghua Er Ke Za Zhi 2017 Oct;55(10):775-779
    Department of Pediatric Respiratory Medicine, Shanghai Children's Hospital, Children's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200040, China.
    Objective: To explore clinical features of idiopathic hypereosinophilic syndrome combined with pulmonary embolism. Method: A retrospective analysis of a patient with idiopathic hypereosinophilic syndrome and pulmonary embolism diagnosed and treated in the Respiratory Department of Shanghai Children's Hospital in September 2016 was performed. A literature search was performed with"Eosinophils increased, thrombosis"as the Chinese keywords in Wanfang database and"idiopathic hypereosinophilic syndrome, deep vein thrombosis"as the English key words in PubMed database. Read More

    World Health Organization-defined eosinophilic disorders: 2017 update on diagnosis, risk stratification, and management.
    Am J Hematol 2017 Nov;92(11):1243-1259
    Stanford Cancer Institute, Stanford, California 94305-5821.
    Disease Overview: The eosinophilias encompass a broad range of nonhematologic (secondary or reactive) and hematologic (primary, clonal) disorders with potential for end-organ damage.

    Diagnosis: Hypereosinophilia has generally been defined as a peripheral blood eosinophil count greater than 1500/mm(3) and may be associated with tissue damage. After exclusion of secondary causes of eosinophilia, diagnostic evaluation of primary eosinophilias relies on a combination of morphologic review of the blood and marrow, standard cytogenetics, fluorescent in situ-hybridization, flow immunocytometry, and T-cell clonality assessment to detect histopathologic or clonal evidence for an acute or chronic myeloid or lymphoproliferative disorder. Read More

    Mepolizumab - a novel option for the treatment of hypereosinophilic syndrome in childhood.
    Pediatr Allergy Immunol 2017 Oct 6. Epub 2017 Oct 6.
    Department of pediatric Pneumology and Immunology, Charité-Universitaetsmedizin Berlin, Germany.
    Background: Mepolizumab was originally intended as a therapeutic agent for atopic asthma in adults, and consequently little is known about its use in children. Up to now corticosteroids have formed the basis of the initial treatment of hypereosinophilic syndromes and are shown to be effective in most patients. To analyse the effect of mepolizumab in children is the aim of this study. Read More

    Hypereosinophilic syndrome with central nervous system involvement: Two case reports and literature review.
    Brain Inj 2017 25;31(12):1695-1700. Epub 2017 Sep 25.
    a Department of Neurology , The Affiliated Hospital of Xuzhou Medical University , Xuzhou , China.
    Objective: To report two cases of hypereosinophilic syndrome (HES) with central nervous system involvement and explore its possible pathogenesis.

    Methods: We have analysed the clinical data and relevant features of two patients who presented themselves to The Affiliated Hospital of Xuzhou Medical University between 2012 and 2015. We have reviewed the relevant literature, elaborated the possible pathogenesis, and discussed the treatment options. Read More

    Loeffler Endocarditis: A Unique Presentation of Right-Sided Heart Failure Due to Eosinophil-Induced Endomyocardial Fibrosis.
    Clin Med Insights Case Rep 2017 30;10:1179547617723643. Epub 2017 Aug 30.
    Department of Cardiology, St. Francis Hospital, Roslyn, NY, USA.
    Loeffler endocarditis is a rare restrictive cardiomyopathy caused by abnormal endomyocardial infiltration of eosinophils, with subsequent tissue damage from degranulation, eventually leading to fibrosis. Although an uncommon entity, it is still a disease with significant morbidity and mortality. Often identified only at late stages, treatment options are limited once fibrosis occurs, usually requiring heart failure medications or surgical intervention. Read More

    Angioimmunoblastic T-cell lymphoma and hypereosinophilic syndrome with FIP1L1/PDGFRA fusion gene effectively treated with imatinib: A case report.
    Medicine (Baltimore) 2017 Sep;96(36):e8001
    aDivision of Gastroenterology and Hematology/Oncology, Department of Medicine bOncology Center, Asahikawa Medical University Hospital, Asahikawa, Japan.
    Rationale: Hypereosinophilic syndrome (HES) is a rare disorder characterized by hypereosinophilia and organ damage. Some cases of HES are caused by the FIP1L1/PDGFRA fusion gene and respond to imatinib. FIP1L1/PDGFRA-positive HES occasionally evolves into chronic eosinophilic leukemia or into another form of myeloproliferative neoplasm; however, the development of a malignant lymphoma is very rare. Read More

    Beyond stroke-uncommon causes of diffusion restriction in the basal ganglia.
    Emerg Radiol 2017 Sep 4. Epub 2017 Sep 4.
    Department of Imaging Sciences, University of Rochester Medical Center, 601 Elmwood Avenue, PO Box 648, Rochester, NY, 14642, USA.
    In the emergency setting, a regional area of restricted diffusion involving the basal ganglia typically represents an acute infarct due to small vessel occlusion. However, it is important to consider additional differentials, specifically systemic causes. This article will review anatomy of the basal ganglia and pertinent associated vasculature, followed by other entities that can be a cause of restricted diffusion. Read More

    Molecular analysis of more than 140 gene fusion variants and aberrant activation of EVI1 and TLX1 in hematological malignancies.
    Ann Hematol 2017 Oct 5;96(10):1605-1623. Epub 2017 Aug 5.
    Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
    Gene fusions are observed in abnormal chromosomal rearrangements such as translocations in hematopoietic malignancies, especially leukemia subtypes. Hence, it is critical to obtain correct information about these rearrangements in order to apply proper treatment techniques. To identify abnormal molecular changes in patients with leukemia, we developed a multiplex reverse transcriptase polymerase chain reaction (MRT-PCR) protocol and investigated more than 140 gene fusions resulting from variations of 29 prevalent chromosomal rearrangements along with EVI1 and TLX1 oncogenic expression in the presence of optimized primers. Read More

    Hypereosinophilic Syndrome Subtype Predicts Responsiveness to Glucocorticoids.
    J Allergy Clin Immunol Pract 2017 Jul 27. Epub 2017 Jul 27.
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, Md.
    Background: Glucocorticoids (GCs) are considered first-line treatment for platelet-derived growth factor α (PDGFRA)-negative hypereosinophilic syndromes (HESs). Despite this, little is known about clinical predictors of GC responsiveness in HES.

    Objective: Knowledge of clinical and laboratory predictors of GC response before initiation of GC could lead to more rational selection of subjects with HES for whom earlier institution of second-line and alternative therapies would be appropriate. Read More

    In vivo neutralization of α4 and β7 integrins inhibits eosinophil trafficking and prevents lung injury during tropical pulmonary eosinophilia in mice.
    Eur J Immunol 2017 Sep 14;47(9):1501-1512. Epub 2017 Aug 14.
    Parasitology Division, CSIR-Central Drug Research Institute, Lucknow, India.
    Integrins regulate leukocyte trafficking during homeostasis and inflammatory conditions. However, the role of α4 and β7 integrins in guiding eosinophil transmigration into the lungs during filarial manifestation of Tropical Pulmonary Eosinophilia (TPE) has not been explored. In this study, mice exhibiting TPE manifestations were administered with in vivo neutralizing antibodies against integrins α4 and β7 or their combination and immuno-pathological parameters were evaluated. Read More

    Ruxolitinib found to cause eyelash growth: a case report.
    J Med Case Rep 2017 Jul 12;11(1):189. Epub 2017 Jul 12.
    Center for Oculofacial & Orbital Surgery, 3771 Katella Ave., #209, Los Alamitos, CA, 90720, USA.
    Background: Hypereosinophilic syndrome is a hematologic disorder in which the eosinophils proliferate. Oral Janus kinase inhibitors are known to be effective treating hypereosinophilic syndrome. Janus kinase inhibitors have also demonstrated efficacy in alopecia. Read More

    Tyrosine Kinase Inhibitors in the Treatment of Eosinophilic Neoplasms and Systemic Mastocytosis.
    Hematol Oncol Clin North Am 2017 Aug;31(4):643-661
    Division of Hematology, Stanford Cancer Institute/Stanford University School of Medicine, 875 Blake Wilbur Drive, Room 2324, Stanford, CA 94305-5821, USA. Electronic address:
    The World Health Organization's semimolecular classification of eosinophilias emphasizes neoplasms driven by fusion tyrosine kinases. More than 80% of patients with systemic mastocytosis carry the KIT D816V mutation, the primary driver of disease pathogenesis. Genetic annotation of these diseases is critical and affords opportunities for targeted therapy. Read More

    Eosinophilic myocarditis and hypereosinophilic syndrome.
    J Saudi Heart Assoc 2017 Jul 17;29(3):211-213. Epub 2016 Nov 17.
    Department of Cardiology, University Hospital of Mohammed VI, Oujda, MoroccoMorocco.
    Hypereosinophilic syndrome (HES) is a heterogeneous group of hematological disorders characterized by a chronic, unexplained hypereosinophilia with tissue damage. Cardiac involvement occurs in ∼20% of patients with HES and represents a major turning point. Cardiac injuries related to eosinophilia are divided into three chronological phases: eosinophilic infiltration, thrombosis, and fibrosis. Read More

    Resolution of a steroid-resistant, hypereosinophilic immune diathesis with mepolizumab and concomitant amelioration of a mixed thrombotic microangiopathy.
    Blood Cells Mol Dis 2017 May 2. Epub 2017 May 2.
    New York Presbyterian Hospital, United States.
    The anaphylatoxins produced by an unbridled complement cascade in atypical hemolytic uremic syndrome (aHUS) can alter the leukocyte environment in tissues and peripheral blood, causing clinically significant eosinophilia. While the membrane attack complex and C5a anaphlatoxin can be suppressed with anti-C5 biologics, the production of C3a is still capable of driving a destructive hypereosinophilic syndrome in spite of anticomplement therapy. The side-effects of glucocorticoids in treating hypereosinophilic syndrome limit their therapeutic index in long-term treatment and this behooves the use of alternative strategies. Read More

    Usefulness of three-dimensional echocardiography in the assessment of valvular involvement in Loeffler endocarditis.
    Echocardiography 2017 Jul 9;34(7):1050-1056. Epub 2017 Jun 9.
    National Medical Center (Siglo XXI), Specialties Hospital (Dr. Bernardo Sepulveda), IMSS, Mexico City, Mexico.
    Loeffler endocarditis is a complication of hypereosinophilic syndrome resulting from eosinophilic infiltration of heart tissue. We report a case of Loeffler endocarditis in which three-dimensional transthoracic and transesophageal echocardiography provided additional information to what was found by two-dimensional transthoracic echocardiography alone. Our case illustrates the usefulness of combined two- and three-dimensional echocardiography in the assessment of Loeffler endocarditis. Read More

    Eosinophilic myocarditis presenting as acute coronary syndrome.
    Turk Kardiyol Dern Ars 2017 Jun;45(4):358-361
    Department of Cardiology, Ege University Faculty of Medicine, İzmir, Turkey.
    Eosinophilic myocarditis (EM) is a rare condition that may result from several heterogeneous eosinophilic diseases, including parasite infection, hypersensitivity reaction, vasculitis, and hypereosinophilic syndrome. Regardless of etiology, the disease may present with various cardiac conditions, such as acute coronary syndrome, heart failure, or arrhythmia. Irreversible endomyocardial fibrosis, which causes restrictive cardiomyopathy, occurs in the late phase of the disease. Read More

    Blomia tropicalis allergen 5 (Blo t 5) T-cell epitopes and their ability to suppress the allergic immune response.
    Immunology 2017 Oct 17;152(2):344-355. Epub 2017 Jul 17.
    Immunology Programme, Life Sciences Institute, Centre for Life Sciences, National University of Singapore, Singapore City, Singapore.
    Blomia tropicalis is the major asthma allergen in the tropics comparable to Dermatophagoides pteronyssinus. However, little is known about the B. tropicalis epitopes recognized by T cells. Read More

    Cardiac involvements in hypereosinophilia-associated syndrome: Case reports and a little review of the literature.
    Echocardiography 2017 Aug 1;34(8):1242-1246. Epub 2017 Jun 1.
    The Department of Cardiovascular Ultrasound, The First Hospital of China Medical University, Shenyang, Liaoning, China.
    Hypereosinophilia-associated syndrome is a rare group of systemic diseases without certain underlying causes. Hypereosinophilic syndrome (HES) and eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg-Strauss syndrome (CSS), are initial considerations, when underlying causes remains unexplained despite of complete evaluation of hypereosinophilia. In this study, we report two rare cases, one case of HES with Loeffler endocarditis, and the other one of EGPA with restrictive cardiomyopathy mimicking myocardial infarction, to further address differential chief cardiac manifestations between HES and EGPA. Read More

    A diagnostic protocol designed for determining allergic causes in patients with blood eosinophilia.
    Mil Med Res 2017 23;4:15. Epub 2017 May 23.
    Purpan Center for Pathophysiology, INSERM UMR U1043, CNRS UMR 5282, Toulouse University, Toulouse, France.
    Background: Blood eosinophilia is a common laboratory abnormality, and its characterization frequently represents a quandary for primary care physicians. Consequently, in France, specialists and particularly hematologists, often must investigate patients who present with blood eosinophilia that often, but not always, occurs because of allergic causes. Both the Departments of Hematology and Parasitology at Toulouse University Hospitals established a collaboration to rule out allergic causes of eosinophilia, particularly helminthiases, prior to initiating more sophisticated investigations. Read More

    Therapeutic effect of anti-IL-5 on eosinophilic myocarditis with large pericardial effusion.
    BMJ Case Rep 2017 May 24;2017. Epub 2017 May 24.
    Rheumatology, State University of New York Downstate Medical Center, Brooklyn, New York, USA.
    Eosinophilic myocarditis (EM) is a rare myocardial disease that results from various eosinophilic diseases, such as idiopathic hypereosinophilic syndrome, helminth infection, medications and vasculitis. Patients with EM may present with different severities, ranging from mild symptoms to a life-threatening condition. Diagnosis of EM is a challenge and requires an extensive workup, including endomyocardial biopsy. Read More

    When a death apparently associated to sexual assault is instead a natural death due to idiopathic hypereosinophilic syndrome: The importance of gamma-hydroxybutyric acid analysis in vitreous humor.
    Leg Med (Tokyo) 2017 May 11;26:92-97. Epub 2017 Apr 11.
    Department of Sciences for Health Promotion and Mother and Child Care, University of Palermo, Palermo, Italy.
    We here report a case involving a 21-year-old female, found dead in a central square of a city in the south of Italy. Initial evidences and circumstances were suggestive of a death associated with a sexual assault. Two peripheral blood and two vitreous humor samples were collected for the purpose of gamma-hydroxybutyric acid (GHB) testing from the dead body at two different post-mortem intervals (PMIs): approximately 2 (t0) and 36 (t1) hours. Read More

    Two cases of atypical hemolytic uremic syndrome (aHUS) and eosinophilic granulomatosis with polyangiitis (EGPA): a possible relationship.
    CEN Case Rep 2017 May 1;6(1):91-97. Epub 2017 Mar 1.
    Departamento de Medicina Celular y Molecular, Centro de Investigaciones Biológicas (CSIC), Madrid, Spain.
    Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by hemolysis, thrombocytopenia, and renal failure. It is related to genetic mutations of the alternative complement pathway and is difficult to differentiate from other prothrombotic microangiopathies. Eosinophilic granulomatosis with polyangiitis (EGPA) (Churg-Strauss syndrome, CSS) is a systemic ANCA-associated vasculitis and a hypereosinophilic disorder where eosinophils seem to induce cell apoptosis and necrosis and therefore, vasculitis. Read More

    Eosinophils in Autoimmune Diseases.
    Front Immunol 2017 27;8:484. Epub 2017 Apr 27.
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Eosinophils are multifunctional granulocytes that contribute to initiation and modulation of inflammation. Their role in asthma and parasitic infections has long been recognized. Growing evidence now reveals a role for eosinophils in autoimmune diseases. Read More

    Bone marrow morphology is a strong discriminator between chronic eosinophilic leukemia, not otherwise specified and reactive idiopathic hypereosinophilic syndrome.
    Haematologica 2017 Aug 11;102(8):1352-1360. Epub 2017 May 11.
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY.
    Chronic eosinophilic leukemia, not otherwise specified can be difficult to distinguish from idiopathic hypereosinophilic syndrome according to the current World Health Organization guideline. To examine whether the morphological features of bone marrow might aid in the differential diagnosis of these two entities, we studied a total of 139 patients with a diagnosis of chronic eosinophilic leukemia, not otherwise specified (n=17) or idiopathic hypereosinophilic syndrome (n=122). As a group, abnormal bone marrow morphological features, resembling myelodysplastic syndromes, myeloproliferative neoplasm or myelodysplastic/myeloproliferative neoplasm, were identified in 40/139 (27%) patients: 16 (94%) of those with chronic eosinophilic leukemia and 24 (20%) of those with hypereosinophilic syndrome. Read More

    Dramatic and early response to low-dose steroid in the treatment of acute eosinophilic myocarditis: a case report.
    BMC Cardiovasc Disord 2017 May 8;17(1):115. Epub 2017 May 8.
    Division of Interventional Cardiology, Cardiovascular Center, Taichung Veterans General Hospital, 1650 Taiwan Boulevard Sect. 4, Taichung, 40705, Taiwan, Republic of China.
    Background: Eosinophilic myocarditis encompasses a variety of etiologies and the prognosis varies. For patients with a hypersensitive response to medications, high-dose corticosteroids and discontinuation of culprit medications are the main treatments.

    Case Presentation: We reported a young man with biopsy-proven eosinophilic myocarditis which was possibly induced by Chinese herbal medicine. Read More

    Hypereosinophilic syndrome: endomyocardial biopsy versus echocardiography to diagnose cardiac involvement.
    Postgrad Med 2017 Jun 25;129(5):517-523. Epub 2017 Apr 25.
    a Division of Allergic Diseases, and Mayo Clinic Program for Mast Cell and Eosinophilic Disorders , Mayo Clinic , Rochester , MN , USA.
    Objective: To compare echocardiograms and endomyocardial biopsies to diagnose cardiac involvement in hypereosinophilic syndrome.

    Methods: We examined the agreement between echocardiography and endomyocardial biopsies to detect cardiac involvement in hypereosinophilic syndrome by reviewing cases identified as hypereosinophilia or hypereosinophilic syndrome in Mayo Clinic databases from January 1978 through June 2009. Single-organ cases of eosinophilia such as eosinophilic fasciitis and eosinophilic gastroenteritis were excluded. Read More

    Reslizumab in Eosinophilic Asthma: A Review.
    Drugs 2017 May;77(7):777-784
    Department of Respiratory Medicine, Ghent University Hospital and Ghent University, Ghent, Belgium.
    Reslizumab (Cinqaero(®); Cinqair(®)) is a humanized monoclonal antibody against interleukin-5 (IL-5), a cytokine mediator of eosinophilic airway inflammation. Reslizumab is indicated as an add-on treatment for severe eosinophilic asthma in adults, on the basis of data from the BREATH phase III clinical trial programme. In three double-blind BREATH studies of up to 52 weeks' duration, adding intravenous reslizumab (3 mg/kg, once every 4 weeks) to the current asthma therapy of patients (aged 12-75 years) with eosinophilic asthma inadequately controlled with inhaled corticosteroids resulted in significant reductions in clinical asthma exacerbation frequency and significant improvements in lung function, asthma control and health-related quality of life relative to adding placebo. Read More

    Daptomycin-associated eosinophilic pneumonia with rechallenge: a case report
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    Int J Clin Pharmacol Ther 2017 Jun;55(6):521-524
    Purpose: A case of daptomycin-associated acute eosinophilic pneumonia (AEP) with positive rechallenge is reported.

    Summary: AEP associated with daptomycin is reported in the literature, and the product labeling contains a warning and precaution statement. Criteria for diagnosing daptomycin-induced AEP varies and generally includes bronchoalveolar lavage (BAL) eosinophils ≥ 25%. Read More

    Urtica dioica attenuates ovalbumin-induced inflammation and lipid peroxidation of lung tissues in rat asthma model.
    Pharm Biol 2017 Dec;55(1):1561-1568
    a Laboratory of Biochemistry and Environmental Toxicology , Department of Biochemistry, Faculty of Sciences, University of Badji Mokhtar , Annaba , Algeria.
    Context: To find bioactive medicinal herbs exerting anti-asthmatic activity, we investigated the effect of an aqueous extract of Urtica dioica L. (Urticaceae) leaves (UD), the closest extract to the Algerian traditional use.

    Objective: In this study, we investigated the in vivo anti-asthmatic and antioxidant activities of nettle extract. Read More

    Imatinib Treatment of Lymphomatoid Papulosis Associated with Myeloproliferative Hypereosinophilic Syndrome Presenting the FIP1L1-PDGFRA Fusion Gene.
    Acta Derm Venereol 2017 Jul;97(7):855-857
    Department of Dermatology, Universitat Autònoma de Barcelona, Hospital del Mar-Parc de Salut Mar, Passeig Marítim 25-29, ES-08003 Barcelona, Spain.

    Evaluation of the prevalence and clinical impact of toxocariasis in patients with eosinophilia of unknown origin.
    Korean J Intern Med 2017 May 30;32(3):523-529. Epub 2017 Mar 30.
    Department of Internal Medicine, Chosun University Hospital, Gwangju, Korea.
    Background/aims: Eosinophilia has numerous diverse causes, and in many patients, it is not possible to establish the cause of eosinophilia. Recently, toxocariasis was introduced as one cause of eosinophilia. The aims of this study were to evaluate the prevalence of toxocariasis and the clinical impact of albendazole treatment for toxocariasis in patients suspected of eosinophilia of unknown origin. Read More

    Total artificial heart implantation for biventricular failure due to eosinophilic myocarditis.
    J Artif Organs 2017 Mar 27. Epub 2017 Mar 27.
    Division of Cardiothoracic Transplantation and Circulatory Support, Texas Heart Institute, Baylor College of Medicine, Cooley 355N, 6770 Bertner Avenue, Houston, TX, 77030, USA.
    Idiopathic hypereosinophilic syndrome is a condition of unknown etiology characterized by proliferation of eosinophils and their infiltration into tissues. Although cardiac involvement is rare, eosinophilic myocarditis can lead to life-threating fulminant congestive heart failure. Treatment of patients with eosinophilic myocarditis is challenging as heart failure can be caused by biventricular dysfunction. Read More

    Hypereosinophilic Syndrome as a Rare Cause of Reversible Biventricular Heart Failure.
    Can J Cardiol 2017 May 20;33(5):688.e5-688.e7. Epub 2017 Jan 20.
    Department of Cardiology, Laikon General Hospital, Athens, Greece.
    Hypereosinophilic syndrome is a rare entity that can develop secondary to overproduction of eosinophilopoietic cytokines or as idiopathic disease. Cardiac involvement, which occurs often, is divided into 3 stages, the latter of which is nonreversible and leads to severe heart failure. Early detection and treatment of the syndrome is essential. Read More

    Cutaneous Larva Migrans Associated With Löffler's Syndrome in a 6-Year-Old Boy.
    Pediatr Infect Dis J 2017 Sep;36(9):912-914
    From the *Department of Dermatology, Beijing Children's Hospital, and †Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
    Cutaneous larva migrans is a frequent dermatologic problem among travelers in tropical areas, but its association with Löffler's syndrome is an extremely rare condition, particularly in children. Here, we describe a 6-year-old boy presenting cutaneous larva migrans associated with Löffler's syndrome. Read More

    Eosinophilic granulomatosis with polyangiitis (formerly known as Churg-Strauss syndrome) as a differential diagnosis of hypereosinophilic syndromes.
    Respir Med Case Rep 2017 8;21:1-6. Epub 2017 Mar 8.
    Department of Pneumology, University Hospital Pedro Ernesto, State University of Rio de Janeiro, Boulevard 28 de Setembro, 77, 2º andar, Vila Isabel, 20551-030, Rio de Janeiro, Brazil; Postgraduate Programme in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Av. Prof. Manoel de Abreu, 444, 2º andar, Vila Isabel, 20550-170, Rio de Janeiro, Brazil.
    Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg-Strauss syndrome, is a rare systemic disease situated between primary small vessel vasculitides associated with antineutrophil cytoplasmic antibodies (ANCAs) and hypereosinophilic syndromes (HES). Here, we present a case of EGPA in a 38-year-old male, with a previous diagnosis of asthma, who presented with fever, migratory lung infiltrates and systemic eosinophilia that was refractory to previous courses of antibiotics. This case highlights the importance of the primary care physician understanding the differential diagnosis of pulmonary eosinophilic syndromes. Read More

    Targeting Interleukin-5 or Interleukin-5Rα: Safety Considerations.
    Drug Saf 2017 Jul;40(7):559-570
    Allergy and Respiratory Diseases, Department of Internal Medicine, IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy.
    Asthma is a highly prevalent chronic disease of the airways; approximately 10% of patients with asthma will experience a severe form of the disease. New understanding of the pathogenesis of asthma has enabled the development of novel drugs and provided hope for patients with asthma. Interleukin (IL)-5 and IL-5 receptor subunit α (IL-5-Rα) plays a crucial role in the development, maturation, and operation of eosinophils so were the first important therapeutic target of these new drugs. Read More

    Non-Bacterial Thrombotic Endocarditis of Aortic Valve due to Hypereosinophilic Syndrome.
    J Heart Valve Dis 2016 Nov;25(6):760-763
    Division of Cardiothoracic Surgery, Harrington Heart and Vascular Institute, Case Western Reserve University, Cleveland, Ohio, USA.
    Hypereosinophilic syndrome (HES) is a rare hematological disorder, which may present with cardiac involvement. The case is presented of a 61-year-old male patient with isolated aortic stenosis secondary to non-bacterial thrombotic endocarditis and HES. The patient underwent successful aortic valve replacement with a bioprosthesis and remained recurrence-free at the 18-month follow up. Read More

    Multiple Valvular Complications of Hypereosinophilic Syndrome.
    J Heart Valve Dis 2016 Nov;25(6):752-755
    Heart Center, Semmelweis University, Budapest, Hungary.
    Endomyocardial fibrosis (EMF) is the most common cardiac abnormality in hyeperosinophilic syndrome (HES), sometimes complicated with mitral valve disease. Mitral valve disease without ventricular manifestation is very rare, however. Case reports link HES to prosthetic valve thrombosis (PVT), but the optimal type of prosthetic valve in HES is not known. Read More

    Acute Eosinophilic Pneumonia: Correlation of Clinical Characteristics With Underlying Cause.
    Chest 2017 Aug 9;152(2):379-385. Epub 2017 Mar 9.
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN. Electronic address:
    Background: Acute eosinophilic pneumonia (AEP) is an uncommon disease, often indistinguishable from ARDS or community-acquired pneumonia at initial presentation. AEP can be idiopathic, but identifiable causes include medications and inhalational exposures, including cigarette smoke.

    Methods: Using a computer-assisted search, we retrospectively identified and reviewed the medical records of all patients diagnosed with AEP between January 1, 1998, and June 30, 2016, at our institution. Read More

    Multiparametric cardiac magnetic resonance imaging (CMR) for the diagnosis of Loeffler's endocarditis: a case report.
    BMC Cardiovasc Disord 2017 Mar 11;17(1):74. Epub 2017 Mar 11.
    Department of Cardiology, Pulmonology and Vascular Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
    Background: Endocarditis parietalis fibroplastica Löfflein (EPF) is a rare form of primary restrictive cardiomyopathy with poor prognosis. It is generally caused by hypereosinophilic syndrome with eosinophilic penetration of the heart. This leads to congestive heart failure in three different stages. Read More

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