5,276 results match your criteria Hypereosinophilic Syndrome


Case for diagnosis. Erythroderma as manifestation of hypereosinophilic syndrome.

An Bras Dermatol 2018 Jun;93(3):451-453

Department of Dermatology, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.

Hypereosinophilic syndrome is defined as persistent eosinophilia (>1500/µL for more than six months) associated with organ involvement, excluding secondary causes. It is a rare, potentially lethal disease that should be considered in cutaneous conditions associated with hypereosinophilia. We report a case of erythroderma as a manifestation of hypereosinophilic syndrome. Read More

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Cardiac involvement in hypereosinophilic syndrome.

Ann Pediatr Cardiol 2018 May-Aug;11(2):217-218

Division of Cardiovascular Medicine, Clemenceau Medical Center, Beirut, Lebanon.

A 9-year-old boy with hypereosinophilic syndrome (HES) was referred for cardiac magnetic resonance (CMR) imaging following an abnormal echocardiogram that showed a large mass layered on the inferolateral wall of the left ventricle, causing secondary severe mitral regurgitation. Cardiac involvement in HES usually affects the ventricular apex. In our case, CMR confirmed the presence of a large mural thrombus of 0. Read More

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[Non-infective endocarditis].

Rev Med Interne 2018 Jun 11. Epub 2018 Jun 11.

Service des maladies infectieuses et de réanimation médicale, CHU Pontchaillou, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex, France. Electronic address:

Non-infective endocarditis, also referred to as non-bacterial thrombotic endocarditis, represent a wide range of rare pathologies, often severe. This review gathered the data available in the literature, to decipher the major information collected on the pathophysiology, the diagnosis and the treatment of these heterogeneous diseases, often misdiagnosed. Characteristics of non-infective endocarditis are similar to infective endocarditis in terms of valvular lesions (mostly left-sided, with regurgitations and vegetations), and their complications (embolism). Read More

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Generalized morphea/eosinophilic fasciitis overlap after epoxy exposure.

JAAD Case Rep 2018 Mar 4;4(2):175-178. Epub 2018 Feb 4.

Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Generalized morphea is associated with epoxy resin vapors and is characterized by the development of lesions shortly after exposure. Morphea presenting along with eosinophilic fasciitis (EF), or morphea/EF overlap, is rare and an indicator of poor prognosis and resistance to treatment. Here we present a case of generalized morphea/EF overlap linked to epoxy exposure. Read More

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Spinal extradural T-cell lymphoma with paraneoplastic hypereosinophilia in a dog: clinicopathological features, treatment, and outcome.

Clin Case Rep 2018 Jun 6;6(6):999-1005. Epub 2018 Apr 6.

Small Animal Hospital School of Veterinary Medicine College of Medical Veterinary and Life Sciences University of Glasgow Bearsden Road Glasgow G61 1QH UK.

Spinal lymphoma is a rare manifestation of a common canine hematopoietic neoplasia. Description of treatment, outcome, and MRI features are scarce. The latter can be heterogeneous, stressing the importance of lesion excision and analysis. Read More

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Mimickers of Urticaria: Urticarial Vasculitis and Autoinflammatory Diseases.

J Allergy Clin Immunol Pract 2018 Jun 2. Epub 2018 Jun 2.

Department of Infectious Diseases and Immunity, Jessa Hospital. BIOMED Research Institute, University of Hasselt, Hasselt, Belgium.

A wide differential diagnosis must be considered in a patient presenting with urticarial plaques. Although acute and chronic urticaria are the commonest diagnoses, other differential diagnoses include polymorphous eruption of pregnancy, mast cell disorders, hypereosinophilic syndrome, urticarial vasculitis, pemphigoid, systemic lupus erythematosus, and autoinflammatory disease. This review will specifically address urticarial vasculitis and autoinflammatory syndromes. Read More

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June 2018
3 Reads

Hypereosinophilic Syndrome in the Differential Diagnosis of Pulmonary Infiltrates with Eosinophilia.

Ann Allergy Asthma Immunol 2018 May 24. Epub 2018 May 24.

Division of Pathology & Laboratory Medicine and Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center; Department of Pathology & Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH.

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A Case of Pulmonary Hypertension Associated with Idiopathic Hypereosinophilic Syndrome.

Int Heart J 2018 May 23. Epub 2018 May 23.

Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.

Hypereosinophilic syndrome (HES) is characterized by multi-organ damage that is associated with tissue hypereosinophilia. A persistently elevated eosinophilic count is also required for the diagnosis of HES. Although HES affects various organs, damage to pulmonary artery is rarely reported. Read More

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May 2018
2 Reads

A Very Rare Case of Hypereosinophilic Syndrome Secondary to Natural Killer/T-Cell Lymphoma.

Case Rep Otolaryngol 2018 26;2018:5965029. Epub 2018 Mar 26.

Department of Otorhinolaryngology and Head & Neck Surgery, University of Yamanashi, Yamanashi, Japan.

Hypereosinophilic syndrome (HES) is a systemic disease characterized by an increased peripheral blood eosinophil count accompanied by systemic organ dysfunction. HES is classified into idiopathic HES, primary (neoplastic) HES (HES), and secondary (reactive) HES (HES). In this case report, a patient who developed peripheral blood eosinophilia and granulation tissue in the pharynx and paranasal sinus, which was initially diagnosed as chronic eosinophilic leukemia (CEL), categorized as HES, but was eventually identified after the patient had died as natural killer/T-cell (NK/T) lymphoma, nasal type (ENKL), categorized as HES, is presented. Read More

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Lymphocytic variant of hypereosinophilic syndrome presenting with polymorphic cutaneous manifestations and nonspecific histopathological findings.

G Ital Dermatol Venereol 2018 May 16. Epub 2018 May 16.

Dermatology Unit, Department of Physiopathology and Transplantation, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.

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Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome.

Case Rep Oncol Med 2018 26;2018:6291614. Epub 2018 Mar 26.

Advocate Illinois Masonic Medical Center, Chicago, IL, USA.

Cytokine storm is a poorly explained clinical entity caused by an undesired and aggrandized immune system response leading to unregulated activation of the proinflammatory cascade, often contributing to multisystem organ failure and even death. Its potentially diverse etiologies and sepsis-like presentation have made it even more challenging to diagnose, and so far, no well-established treatment protocol has been proposed. Its association with certain medications, especially with monoclonal antibodies, has well been reported in literature. Read More

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Bilateral Conjunctival Granulomas in A Young Lady with Hypereosinophilic Syndrome - A Case Report.

Ocul Immunol Inflamm 2018 May 17:1-3. Epub 2018 May 17.

b Vision Research Foundation, Sankara Nethralaya , Chennai , India.

Purpose: To report an interesting case of bilateral conjunctival granulomas in a young lady with hypereosiniophilic syndrome.

Materials & Methods: Retrospective interventional case report Results: A 37-year-old lady presented with irritation and redness in both eyes of 15-day duration. She had a history of abdominal pain and diarrhea since 8 months for which she has been extensively investigated including a positron emission tomography (PET) scan and an ileal biopsy which showed chronic granulomatous inflammation with eosinophils. Read More

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Parasitic Hypereosinophilia in Childhood: a Diagnostic Challenge.

Mediterr J Hematol Infect Dis 2018 1;10(1):e2018034. Epub 2018 May 1.

Hematology, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

Severe hypereosinophilia (HE) in children is rare, and its etiological diagnosis is challenging. We describe a case of a 30-month-old boy, living in a rural area, who was admitted to our Clinic with a 7-day history of fever and severe hypereosinophilia. A comprehensive diagnostic workup could not identify the cause of this condition. Read More

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Long-Term Clinical Outcomes of High-Dose Mepolizumab Treatment for Hypereosinophilic Syndrome.

J Allergy Clin Immunol Pract 2018 May 8. Epub 2018 May 8.

Human Eosinophil Section, LPD, NIAID, NIH, Bethesda, Md.

Background: Conventional therapies for hypereosinophilic syndromes (HES) have variable efficacy and carry significant long-term toxicities. Anti-IL-5 (mepolizumab) therapy has a glucocorticoid (GC)-sparing effect in GC-sensitive HES, but the efficacy of mepolizumab in treatment-refractory HES patients with severe disease has not been examined to date.

Objective: To identify predictors of response to mepolizumab in subjects with severe treatment-refractory HES and compare long-term outcomes in these subjects with HES subjects treated with conventional therapies. Read More

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May 2018
5 Reads

Hypereosinophilic syndrome preceding a diagnosis of B-cell lymphoma.

Tumori 2018 Mar 1:300891618763211. Epub 2018 Mar 1.

3 Department of Hematology and Oncology, St. Barnabas Hospital, Bronx, New York, USA.

Introduction: Hypereosinophilic syndrome (HES) is a rare condition characterized by eosinophilia and organ destruction secondary to eosinophilic infiltration. The coexistence of primary B-cell lymphoma and hypereosinophilic syndrome is extremely rare. We present a case of HES that preceded the diagnosis of diffuse large B-cell lymphoma. Read More

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March 2018
2 Reads

Targeting the Interleukin-5 Pathway for Treatment of Eosinophilic Conditions Other than Asthma.

Front Med (Lausanne) 2018 6;5:49. Epub 2018 Apr 6.

Hôpital Erasme, Department of Internal Medicine, Université Libre de Bruxelles, Brussels, Belgium.

Improved understanding of the contribution of eosinophils to various chronic inflammatory conditions, most notably allergic asthma, has encouraged development of monoclonal antibodies specifically targeting mediators and surface receptors involved in eosinophil expansion and activation. The pivotal role of interleukin-5 (IL-5) in eosinophil biology, its high specificity for this leukocyte subset, and its involvement in the majority of eosinophilic conditions make it a very enticing target for treatment of eosinophil-mediated disorders. Two types of antibodies have been developed to target eosinophils: antibodies against IL-5 (mepolizumab and reslizumab), and an antibody against the IL-5-receptor-alpha-chain (IL-5Rα) (benralizumab). Read More

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April 2018
2 Reads

Diagnosis and Novel Approaches to the Treatment of Hypereosinophilic Syndromes.

Curr Hematol Malig Rep 2018 Apr 21. Epub 2018 Apr 21.

Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, 240 E. Huron Street, Room M306, Chicago, IL, 60611, USA.

Purpose Of Review: Hypereosinophilic syndrome (HES) is characterized by persistent hypereosinophilia associated with end-organ damage. As our understanding of the pathogenesis of various forms of HES broadens, so does our ability to tailor steroid-sparing therapies for each subtype. The purpose of this review is to summarize recent literature related to the etiology, diagnosis, and management of HES. Read More

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Eosinophilic Fasciitis in Association With Hypereosinophilic Syndrome in an HIV-Infected Patient With Severe Multiorgan Involvement.

J Investig Allergol Clin Immunol 2018 Apr;28(2):126-128

Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona, Spain.

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April 2018
1 Read

Protective Role of Eosinophils and TNFa after Ozone Inhalation.

Res Rep Health Eff Inst 2017 Mar(191):1-41

Introduction: Exposure to ozone induces deleterious responses in the airways that include shortness of breath, inflammation, and bronchoconstriction. People with asthma have increased airway sensitivity to ozone and other irritants. Dr. Read More

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March 2017
2 Reads

Hypereosinophilic Syndrome Complicated by Eosinophilic Myocarditis With Dramatic Response to Steroid.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618764512. Epub 2018 Mar 19.

Interfaith Medical Center, Brooklyn, NY, USA.

Eosinophilic myocarditis is an infiltrative disease that affects the myocardium leading to various presentations. It can be precipitated by medications, helminthiasis, or hypereosinophilic syndrome. We present the case of a young, male patient who presented with palpitations and dyspnea and was found to have heart failure with reduced ejection fracture of 12%. Read More

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March 2018
1 Read

Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibitor for PDGFRα driving chronic eosinophilic leukemia.

Eur J Med Chem 2018 Apr 20;150:366-384. Epub 2018 Mar 20.

High Magnetic Field Laboratory, Chinese Academy of Sciences, Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui, 230031, PR China; CHMFL-HCMTC Target Therapy Joint Laboratory, 350 Shushanhu Road, Hefei, Anhui, 230031, PR China; Hefei Science Center, Chinese Academy of Sciences, 350 Shushanhu Road, Hefei, 230031, Anhui, PR China. Electronic address:

Through exploration of the non-highly conserved allosteric hydrophobic pocket generated by DFG-out shifting in the inactive conformation, we discovered a highly selective type II PDGFRα kinase inhibitor 15i (CHMFL-PDGFRα-159), which exhibited strong potency against purified PDGFRα (IC: 132 nM) but not structurally similar PDGFRβ, ABL, c-KIT and VEGFR2 kinases. In addition, it displayed a high selectivity profile (S score (10) = 0.02) at the concentration of 1 μM among 468 kinases/mutants in the KINOMEscan profiling. Read More

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April 2018
6 Reads

Loeffler endocarditis as a rare cause of heart failure with preserved ejection fraction: A case report and review of literature.

Medicine (Baltimore) 2018 Mar;97(11):e0079

Department of Cardiology, The First Hospital of Jilin University, Changchun, China.

Rationale: Hypereosinophilic syndrome (HES) is a rare disease characterized by hypereosinophilia and its ensuing organ damage. Cardiac involvement is divided into 3 chronological stages: an acute necrotic stage; a thrombus formation stage; and a fibrotic stage. Infiltration of the myocardium by eosinophilic cells followed by endomyocardial fibrosis is known as "Loeffler endocarditis. Read More

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March 2018
3 Reads

A young female presenting with heart failure secondary to eosinophilic myocarditis: a case report and review of the literature.

BMC Res Notes 2018 Mar 9;11(1):168. Epub 2018 Mar 9.

Department of Medicine, University of Peradeniiya, Peradeniya, Sri Lanka.

Background: Eosinophilic myocarditis is one of the fatal complications of idiopathic hypereosinophilic syndromes. Given the rarity of this form of myocarditis, it is often under-recognized. We describe a young girl who presented with features of heart failure. Read More

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March 2018
5 Reads

Hypereosinophilic syndrome presenting acutely with neurologic signs.

Ann Allergy Asthma Immunol 2018 May 28;120(5):461-464. Epub 2018 Feb 28.

Department of Medicine, Division of Clinical Immunology and Allergy, University of Mississippi Medical Center, Jackson, Mississippi.

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May 2018
1 Read

Treatment of hypereosinophilic syndrome and eosinophilic dermatitis with reslizumab.

Authors:
Merin Kuruvilla

Ann Allergy Asthma Immunol 2018 Jun 26;120(6):670-671. Epub 2018 Feb 26.

Allergy/Immunology, Emory University, Atlanta, Georgia. Electronic address:

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Severe Multi-Organ Failure and Hypereosinophilia: When to Call It "Idiopathic"?

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618758347. Epub 2018 Feb 15.

Center of Research of Immunopathology and Rare Diseases, Coordinating Center of Piemonte and Valle d'Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, and SCDU Nephrology and Dialysis, University of Turin and S. Giovanni Bosco Hospital, Turin, Italy.

The hypereosinophilic syndrome is a rare disease characterized by the association between high absolute eosinophil count and eosinophil-mediated organ damage. We describe a case of a 70-year-old male with an absolute eosinophil count of 2130 cells/µL. Clinical symptoms and signs included the following: severe asthenia, axonal sensitive motor neuropathy, basal pleural effusion with signs of hypoventilation on chest radiography, and gastrointestinal symptoms such as severe diarrhea, weight loss (-10 kg in 6 months), abdominal pain, and vomiting. Read More

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February 2018
1 Read

Concurrent eosinophilia and IgG4-related disease in a child: A case report and review of the literature.

Exp Ther Med 2018 Mar 12;15(3):2739-2748. Epub 2018 Jan 12.

Department of Hematology, Hangzhou First People's Hospital, Hangzhou, Zhejiang 310006, P.R. China.

The current study presents the case of a 9-year-old Chinese boy who presented with eosinophilia and elevated serum levels of immunoglobulin G4 (IgG4). A bone marrow puncture identified an elevated eosinophil rate of 23% (normal range, <5%), which indicated eosinophilia. However, gene analysis, fluorescent hybridization and other examinations, including bone marrow aspiration, blood routine, auto-antibody tests and parasitic and allergens screening, contradicted a diagnosis of secondary or clonal eosinophilia. Read More

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March 2018
2 Reads

Detection of specific bacterial agents by quantitative PCR assays in the bronchoalveolar lavage fluid of dogs with eosinophilic bronchopneumopathy vs. dogs with chronic bronchitis and healthy dogs.

Vet J 2018 02 18;232:52-56. Epub 2017 Dec 18.

Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, 4000 Liège, Belgium.

In humans, Mycoplasma pneumoniae and Bordetella pertussis infections are suggested to trigger or exacerbate asthma. Whether Mycoplasma or Bordetella are associated with chronic inflammatory bronchial diseases in dogs has not been investigated. The aim of this study was to assess detection rates of Mycoplasma canis (M. Read More

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February 2018

[Portal vein thrombosis associated with idiopathic hypereosinophilic syndrome].

Rinsho Ketsueki 2018;59(1):45-50

Department of Hematology, Tokyo Metropolitan Tama Synthesis Medical Center.

A 35-year-old man who previously underwent splenectomy for hereditary spherocytosis at age 29 visited our hospital complaining of fatigue that had started 7 days ago and right upper abdominal pain. Laboratory data showed increased white blood cell and eosinophil count accompanied by severe transaminitis and clotting abnormalities. Computed tomography scan showed multiple embolisms in the portal vein, superior mesenteric vein, right pulmonary artery, and inferior vena cava. Read More

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January 2018
3 Reads

Lymphocyte-Variant Hypereosinophilic Syndrome With Eosinophilic Myocarditis Treated With Steroids and Pegylated Interferon Alfa-2a.

Am J Med Sci 2018 Feb 6;355(2):201-202. Epub 2017 Apr 6.

Division of Hematology, Gordon and Leslie Diamond Health Care Centre, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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February 2018
4 Reads

Eosinophilic Gastrointestinal Disorders Pathology.

Front Med (Lausanne) 2017 15;4:261. Epub 2018 Jan 15.

Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.

Eosinophilic gastrointestinal disorders (EGID) are characterized pathologically by excess eosinophils in mucosal biopsies of one or multiple sites in the gastrointestinal (GI) tract, simultaneously or sequentially. Eosinophilic esophagitis (EoE) is the best characterized EGID, and in most patients it is an abnormal immune-mediated response to food antigens. Current recommendations for diagnosis include signs and symptoms of esophageal dysfunction that do not respond to proton-pump inhibitor therapy, and esophageal biopsies that exhibit at least 15 intraepithelial eosinophils in at least one high power field (HPF). Read More

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January 2018
9 Reads

Drug-induced eosinophilic pneumonia: A review of 196 case reports.

Medicine (Baltimore) 2018 Jan;97(4):e9688

Background And Objective: Eosinophilic pneumonia (EP) is an important subset of patients who present with pulmonary infiltrates and eosinophilia (PIE). EP is classified by chronicity and etiology and drug-induced EP is the main cause of secondary EP. The primary goal of this review was to examine all the case reports published since the syndrome was defined in 1990. Read More

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January 2018
20 Reads

Clinical and Biological Markers in Hypereosinophilic Syndromes.

Front Med (Lausanne) 2017 22;4:240. Epub 2017 Dec 22.

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

Hypereosinophilic syndromes (HES) are rare, heterogeneous syndromes characterized by markedly elevated eosinophil counts in the blood and/or tissue and evidence of eosinophil-associated pathology. Although parasitic infections, drug hypersensitivity, and other disorders of defined etiology can present as HES (associated HES), treatment is directed at the underlying cause rather than the eosinophilia itself. A number of additional subtypes of HES have been described, based on clinical and laboratory features. Read More

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December 2017
3 Reads

Aortic stiffness is increased in patients with hypereosinophilic syndrome being in early necrotic phase.

Quant Imaging Med Surg 2017 Dec;7(6):636-640

2nd Department of Medicine and Cardiology Centre, 2nd Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.

Background: Persistent eosinophilia and eosinophil-mediated single- or multiple-organ damage are typical features of hypereosinophilic syndrome (HES). Theoretically, eosinophilic infiltration of the ascending aortic wall could not be excluded in HES, therefore the present study aimed to test whether HES is associated with abnormalities in aortic elastic properties.

Methods: The present study comprised 10 HES patients (mean age: 57. Read More

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December 2017
17 Reads

The significance of eosinophils in predicting the severity of acute ischemic stroke.

Oncotarget 2017 Nov 31;8(61):104238-104246. Epub 2017 Oct 31.

Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.

Background: Previous studies have shown that tumor-associated tissue eosinophilia have a role in various types of solid tumors. However, the relationship between eosinophil and acute ischemic stroke (AIS) is unclear. We aimed to investigate the diagnostic significance of eosinophil in AIS patients. Read More

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November 2017
7 Reads

(A Critical Appraisal of) Classification of Hypereosinophilic Disorders.

Front Med (Lausanne) 2017 5;4:216. Epub 2017 Dec 5.

Université de Lille, INSERM, CHU Lille, U995 - LIRIC - Lille Inflammation Research International Center, Institut d'Immunologie, Centre de Référence des Syndromes Hyperéosinophiliques-CEREO, Unité d'Immunologie Clinique, Lille, France.

Hypereosinophilia (HE) is a heterogeneous condition that can be reported in various (namely inflammatory, allergic, infectious, or neoplastic) diseases with distinct pathophysiological pathways. In 1975, Chusid et al. published the first diagnostic criteria of hypereosinophilic syndromes (HES). Read More

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December 2017
7 Reads

Noncanonical NF-κB signaling and the essential kinase NIK modulate crucial features associated with eosinophilic esophagitis pathogenesis.

Dis Model Mech 2017 Dec 19;10(12):1517-1527. Epub 2017 Dec 19.

Department of Biomedical Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24060, USA

Eosinophilic esophagitis (EoE) is an allergic disease of the esophagus driven by T cell and eosinophil responses to dietary allergens, resulting in chronic mucosal inflammation. Few spontaneous animal models of esophageal eosinophilia exist, with most studies relying on artificial sensitization procedures. NF-κB-inducing kinase (NIK; MAP3K14) is a key signaling molecule of the noncanonical NF-κB (NFKB1) pathway, an alternative signaling cascade producing chemokines involved in lymphoid stroma development and leukocyte trafficking. Read More

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December 2017
7 Reads

The right atrium in idiopathic hypereosinophilic syndrome : Insights from the 3D speckle tracking echocardiographic MAGYAR-Path Study.

Herz 2017 Dec 12. Epub 2017 Dec 12.

2nd Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Semmelweis Street 8, P.O. Box 427, 6725, Szeged, Hungary.

Background: Idiopathic hypereosinophilic syndrome is characterized by a persistent eosinophil blood count of >1.5 × 10 cells/l and organ damage, independent of the primary and secondary causes of eosinophilia. The purpose of the present study was to assess the three-dimensional speckle tracking echocardiography-derived right atrial volumetric and functional properties between hypereosinophilic syndrome patients and matched controls. Read More

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December 2017
5 Reads

Biomarkers for severe eosinophilic asthma.

J Allergy Clin Immunol 2017 Dec;140(6):1509-1518

Respiratory Medicine Unit and Oxford Respiratory BRC, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

The last decade has seen the approval of several new biologics for the treatment of severe asthma-targeting specific endotypes and phenotypes. This review will examine how evidence generated from the mepolizumab clinical development program showed that blood eosinophil counts, rather than sputum or tissue eosinophil counts, evolved as a pharmacodynamic and predictive biomarker for the efficacy of treatment with mepolizumab in patients with severe eosinophilic asthma. Based on the available evidence and combined with clinical judgement, a baseline blood eosinophil threshold of 150 cells/μL or greater or a historical blood eosinophil threshold of 300 cells/μL or greater will allow selection of patients with severe eosinophilic asthma who are most likely to achieve clinically significant reductions in the rate of exacerbations with mepolizumab treatment. Read More

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December 2017
6 Reads

Pneumatosis Cystoides Intestinalis.

N Engl J Med 2017 Dec;377(23):2266

Okayama University Graduate School of Medicine, Okayama, Japan

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December 2017
4 Reads

Recurrent Malignancy-Associated Atypical Neutrophilic Dermatosis With Noninfectious Shock.

Am J Med Sci 2017 12 20;354(6):626-632. Epub 2016 Oct 20.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

Sweet syndrome (SS) or acute febrile neutrophilic dermatosis presents with the sudden onset of fever, leukocytosis and tender, erythematous, edematous, well-demarcated papules and plaques that histopathologically demonstrate a dense neutrophilic infiltrate. A total of 20% of patients with SS have malignancy-associated disease that can present with bullous or atypical skin lesions that mimic pyoderma gangrenosum, another neutrophilic dermatosis. Both entities exist on a spectrum, and in the context of underlying malignancy, these neutrophilic diseases become less clinically distinct. Read More

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December 2017
4 Reads

Eosinophilic Myocarditis.

Am J Med Sci 2017 11 6;354(5):486-492. Epub 2017 Apr 6.

Division of Hematology, University of British Columbia, Vancouver, British Columbia. Electronic address:

Persistent eosinophilia can cause cardiac tissue damage, typically in the form of eosinophilic myocarditis, whether the underlying cause is reactive, a clonal myeloid disorder, or idiopathic hypereosinophilic syndrome (HES). Eosinophilic myocarditis ranges from mild localized disease to multifocal widespread infiltrates associated with myocardial necrosis, thrombotic complications and endomyocardial fibrosis. Systemic treatment varies widely depending on the underlying cause, so thorough investigation and precise diagnosis are essential. Read More

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November 2017
10 Reads

Ther Umsch 2017 Nov;74(6):327-332

1 Klinik für Pneumologie, Spital Tiefenau, Bern.

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November 2017
1 Read

A Case of Loeffler Endocarditis That Showed Endomyocardial Systolic Dysfunction Detected by Layer Specific Strain Analysis.

Int Heart J 2017 Dec 17;58(6):1001-1003. Epub 2017 Nov 17.

Department of Cardiovascular Ultrasound, The First Hospital of China Medical University.

Loeffler endocarditis is a rare comprehensive cardiac manifestation caused by eosinophilic cell infiltrations and is present in 50%-60% of patients with hypereosinophilic syndrome (HES). Left ventricle (LV) endocardial systolic dysfunction is a major cause of morbidity and mortality in HES and Loeffler endocarditis. We present a case of Loeffler endocarditis, whose left ventricular (LV) systolic dysfunction and endocardial systolic dysfunction were first neglected by conventional transthoracic echocardiography (TTE), but were later pointed out by layer-specific longitudinal strain analysis. Read More

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December 2017
4 Reads

Biologic Agents for the Treatment of Hypereosinophilic Syndromes.

J Allergy Clin Immunol Pract 2017 Nov - Dec;5(6):1502-1509

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Md. Electronic address:

Hypereosinophilic syndromes (HES) are a heterogeneous group of rare disorders defined by the presence of marked peripheral or tissue eosinophilia resulting in end-organ damage. Although conventional therapies, including glucocorticoids, hydroxyurea, and IFN-α, are initially effective in reducing eosinophilia and symptoms in a majority of patients with platelet-derived growth factor mutation-negative HES, the development of resistance and treatment-related toxicity are common. In contrast, targeted therapy with the tyrosine kinase inhibitor, imatinib, is well tolerated but effective only in the subset of patients with HES with a primary myeloid disorder. Read More

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June 2018
2 Reads

Eosinophilic Myocarditis as a Cause of Acute Cardiac Syndromes: The Importance of Awareness.

Authors:
Leslie T Cooper

J Am Coll Cardiol 2017 Nov;70(19):2376-2377

Department of Cardiovascular Medicine, Mayo Clinic in Florida, Jacksonville, Florida. Electronic address:

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November 2017
2 Reads

Lung-Infiltrating Foxp3 Regulatory T Cells Are Quantitatively and Qualitatively Different during Eosinophilic and Neutrophilic Allergic Airway Inflammation but Essential To Control the Inflammation.

J Immunol 2017 12 1;199(12):3943-3951. Epub 2017 Nov 1.

Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195; and

Understanding functions of Foxp3 regulatory T cells (Tregs) during allergic airway inflammation remains incomplete. In this study, we report that, during cockroach Ag-induced allergic airway inflammation, Foxp3 Tregs are rapidly mobilized into the inflamed lung tissues. However, the level of Treg accumulation in the lung was different depending on the type of inflammation. Read More

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December 2017
8 Reads

Idiopathic hypereosinophilia is clonal disorder? Clonality identified by targeted sequencing.

PLoS One 2017 31;12(10):e0185602. Epub 2017 Oct 31.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

Idiopathic hypereosinophilia (IHE)/idiopathic hypereosinophilic syndrome (IHES) has been defined by a persistent elevation of the blood eosinophil count exceeding 1.5×103/μL, without evidence of reactive or clonal causes. While T-cell clonality assessment has been recommended for unexplained hypereosinophilia, this approach is not often applied to routine practice in the clinic. Read More

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November 2017
3 Reads

Eosinophilic Lung Disease.

Am J Med Sci 2017 10 15;354(4):339-349. Epub 2017 Mar 15.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

Eosinophils are involved in the pathogenesis of a number of lung diseases. Recent advances in eosinophil biology have now produced clinically applicable therapies that seek to counter eosinophilia in blood and lungs. This article reviews the basic biology of eosinophils and their role in mediating T-helper 2 cell responses. Read More

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October 2017
2 Reads