5,420 results match your criteria Hypereosinophilic Syndrome


Benralizumab for -Negative Hypereosinophilic Syndrome.

N Engl J Med 2019 04;380(14):1336-1346

From the Laboratory of Parasitic Diseases (F.L.K., F.L., M.M., J.W., L.W., T.B., T.M., B.P., P.Y., P.K., A.D.K.) and Biostatistics Research Branch (M.P.F.), National Institute of Allergy and Infectious Diseases, the Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (H.A., S.K.), and the Laboratory of Pathology, National Cancer Institute (A.P., M.Q.), National Institutes of Health (NIH), and the Departments of Laboratory Medicine (J.H.E., X.S., I.M.) and Transfusion Medicine (S.R.P.), NIH Clinical Center, Bethesda, Washington Adventist Hospital, Takoma Park (T.M.), and MedImmune (N.L., R.K.) and AstraZeneca (P.N., M.G.), Gaithersburg - all in Maryland; the Department of Veteran Affairs, Tennessee Valley Healthcare System, Chattanooga (J.H.E.); and MedImmune, South San Francisco, CA (L.Y.).

Background: Hypereosinophilic syndrome is a group of diseases defined by marked eosinophilia in blood or tissue and eosinophil-related clinical manifestations. Benralizumab is a monoclonal antibody against interleukin-5 receptor α, which is expressed on human eosinophils.

Methods: In this randomized, double-blind, placebo-controlled, phase 2 trial, we administered a series of three monthly subcutaneous injections of either benralizumab (at a dose of 30 mg) or placebo in 20 symptomatic patients who had -negative hypereosinophilic syndrome and an absolute eosinophil count of at least 1000 cells per cubic millimeter; all the patients were receiving stable therapy (drugs or dietary changes) for this disease. Read More

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http://dx.doi.org/10.1056/NEJMoa1812185DOI Listing
April 2019
6 Reads
55.873 Impact Factor

[Hypereosinophilic syndrome and other rheumatic diseases with hypereosinophilia].

Z Rheumatol 2019 Apr 1. Epub 2019 Apr 1.

Klinik für Innere Medizin I, Sektion Rheumatologie, Exzellenzzentrum Entzündungsmedizin, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Deutschland.

Among the eosinophilic diseases treated by rheumatologists other than eosinophilic granulomatosis with polyangiitis, there are further organ-related and systemic diseases with hypereosinophilia. Only the exact differential diagnostic demarcation of the diseases enables a pathogenetic oriented treatment. This article focuses on the hypereosinophilic syndromes. Read More

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http://dx.doi.org/10.1007/s00393-019-0623-xDOI Listing
April 2019
3 Reads

Idiopathic Hypereosinophilic Syndrome in an Elderly Female: A Case Report.

Am J Case Rep 2019 Mar 23;20:381-384. Epub 2019 Mar 23.

Department of Pulmonary, Critical Care and Sleep Medicine, University of Colorado, Denver, CO, USA.

BACKGROUND Hypereosinophilic syndrome (HES) is defined as hypereosinophilia with eosinophil mediated organ damage or dysfunction, provided that other causes of organ damage have been excluded. CASE REPORT An 83-year-old female presented with worsening dyspnea for 3 weeks. She was initially diagnosed with bronchitis and prescribed oral antibiotics along with prednisone taper. Read More

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http://dx.doi.org/10.12659/AJCR.912747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441311PMC
March 2019
1 Read

Spectrum of pulmonary aspergillosis in Hyper IgE syndrome with autosomal dominant STAT3 deficiency.

J Allergy Clin Immunol Pract 2019 Mar 13. Epub 2019 Mar 13.

Service de Maladies Infectieuses et Tropicales, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (APHP), Université Paris Descartes, Paris, France; Institut Pasteur, CNRS, Centre National de Référence Mycoses Invasives et Antifongiques, Unité de Mycologie Moléculaire, UMR 2000, Paris,France. Electronic address:

Background: Autosomal dominant signal transducer and activator of transcription 3 (STAT3) deficiency predisposes to recurrent bacterial pneumonia, complicated by bronchiectasis and cavitations. Aspergillosis is a major cause of morbidity in these patients. However, its diagnosis, classification, and treatment are challenging. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.041DOI Listing
March 2019
3 Reads

Docosahexaenoic Acid Inhibits Proliferation of EoL-1 Leukemia Cells and Induces Cell Cycle Arrest and Cell Differentiation.

Nutrients 2019 Mar 7;11(3). Epub 2019 Mar 7.

Laboratory of Biochemistry, Department of Biological Applications & Technologies, University of Ioannina, 45110 Ioannina, Greece.

Τhe effect of docosahexaenoic acid (DHA, an omega-3 polyunsaturated fatty acid) upon the proliferation of EoL-1 (Eosinophilic leukemia) cell line was assessed, while additional cellular events during the antiproliferative action were recorded. DHA inhibited EoL-1 cells growth dose-dependently by inducing growth arrest at G0/1 phase of the cell cycle. After DHA addition to the cells, the expression of oncogene was decreased, -mRNA overexpression was observed which was used as a marker of differentiation, and -mRNA increase was recorded. Read More

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http://dx.doi.org/10.3390/nu11030574DOI Listing

Causes of eosinophilic ascites - a systematic review.

Rom J Intern Med 2018 Dec 1. Epub 2018 Dec 1.

Carol Davila School of Medicine, Bucharest, Romania.

Background: In the last years an uprising interest for a relatively unknown entity, eosinophilic ascites (EA), has been recorded. Our aim is to investigate the potential causes of EA development, as well as clinical, laboratory, endoscopic and radiologic features, management and outcome in these patients.

Methods: The following research was performed on PubMed (MEDLINE) database using the medical subject headings [Mesh] terms "Ascites" AND "Eosinophils". Read More

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http://content.sciendo.com/view/journals/rjim/ahead-of-print
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http://dx.doi.org/10.2478/rjim-2018-0041DOI Listing
December 2018
14 Reads

Coronary Arteries and the Cell Count.

Circulation 2019 Feb;139(9):1228-1233

Division of Cardiology, University of California, San Francisco (P.D., I.H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036124DOI Listing
February 2019
1 Read

Idiopathic hypereosinophilic syndrome presenting with multiple organ damage: A case report.

Medicine (Baltimore) 2019 Mar;98(10):e14532

Rationale: Idiopathic hypereosinophilic syndrome (IHES) is a rare disease in which patients which present with eosinophilia-associated damage. Previous studies focused on organ damage from increased eosinophilic granulocytosis. We report IHES in a patient who presented with multiple organ damage (MOD). Read More

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http://dx.doi.org/10.1097/MD.0000000000014532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417528PMC
March 2019
13 Reads

Cigarette smoking-induced acute eosinophilic pneumonia: A case report.

Medicine (Baltimore) 2019 Mar;98(9):e14704

Department of Respiratory Medicine, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian.

Rationale: Acute eosinophilic pneumonia (AEP) is a rare pulmonary disease, which is characterized by diffuse pulmonary eosinophilia. The pathogenesis remains unknown. Here we report a patient with AEP following a recently acquired habit of smoking. Read More

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http://dx.doi.org/10.1097/MD.0000000000014704DOI Listing
March 2019
1 Read

A case of Loeffler's endocarditis after initiation of adalimumab.

J Community Hosp Intern Med Perspect 2019 11;9(1):29-32. Epub 2019 Feb 11.

Department of Critical Care/Pulmonary Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.

Tumor necrosis factor antagonists (anti-TNF) are increasingly prescribed as maintenance therapy for a variety of autoimmune conditions. Therefore, frequent monitoring and awareness of side effects are of the utmost importance. Adalimumab is known to cause peripheral eosinophilia, but there are few reports of more severe adverse events. Read More

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http://dx.doi.org/10.1080/20009666.2018.1562852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374942PMC
February 2019
5 Reads

An Unusual Case of Tricuspid Stenosis.

Eur J Case Rep Intern Med 2018 24;5(4):000836. Epub 2018 Apr 24.

Internal Medicine Department, Centro Hospitalar de São João, Porto, Portugal.

Tricuspid stenosis is an uncommon valvular abnormality commonly associated with other valvular lesions. Ebstein's anomaly is a rare congenital heart malformation characterized primarily by abnormalities of the tricuspid valve and right ventricle. Endomyocardial fibrosis is a restrictive cardiomyopathy observed in tropical and subtropical regions. Read More

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http://dx.doi.org/10.12890/2018_000836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346752PMC
April 2018
1 Read

Tricuspid valve relocation with endomyocardial fibrosis removal for Löeffler's endocarditis.

Eur J Cardiothorac Surg 2019 Feb 8. Epub 2019 Feb 8.

Division of Cardiovascular Surgery, Department of Surgery, Shiga University of Medical Science, Otsu, Japan.

Löffler endocarditis with hypereosinophilic syndrome is rare but can cause critical ventricular obliteration by endomyocardial fibrosis. A 52-year-old woman experienced severe right heart failure with extreme shrinkage of her right ventricle, severe tricuspid regurgitation and marked right atrial enlargement. Preoperative tests showed identical pressures in the right atrium and pulmonary artery. Read More

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http://dx.doi.org/10.1093/ejcts/ezy487DOI Listing
February 2019
2 Reads

Abnormal T-cell phenotype in episodic angioedema with hypereosinophilia (Gleich's syndrome): frequency, clinical implication and prognosis.

J Am Acad Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Service de Médecine Interne, Université Versailles Saint-Quentin-en-Yvelines, Centre de Référence des Syndromes Hyperéosinophiliques (CEREO), Hôpital Foch, Suresnes, France.

Background: Episodic Angioedema with eosinophilia (EAE, Gleich's syndrome) is a rare disorder consisting of recurrent episodes of angioedema, hypereosinophilia and frequent elevated serum Immunoglobin M.

Methods: We conducted a retrospective multicenter nationwide study regarding the clinical spectrum and therapeutic management of patients with EAE in France.

Results: Thirty patients were included with a median age at diagnosis of 41 years [5-84]. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.02.001DOI Listing
February 2019
12 Reads

Eosinophilic pneumonia: remember topical drugs as a potential etiology.

J Bras Pneumol 2018 Nov-Dec;44(6):522-524

. Divisão de Pneumologia, Instituto do Coração - InCor - Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP) Brasil.

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http://dx.doi.org/10.1590/S1806-37562018000000028DOI Listing
March 2019
1 Read

Mutation in Gene Can Cause Syndromic Multisystem Autoimmune Disease With Acute Liver Failure.

Pediatrics 2019 Feb;143(2)

Departments of Pediatrics, Gastroenterology, and Hepatology and

Pediatric intractable autoimmune hepatitis is rare and may be responsible for acute liver failure. Mutations in the itchy E3 ubiquitin protein ligase () gene (located on chromosome 20q11.22) can lead to a deficiency of the encoded protein, resulting in increased T-cell activity with lack of immune tolerance and manifestation of a complex systemic autoimmune disease. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-1554DOI Listing
February 2019
20 Reads

Siglec-7 on peripheral blood eosinophils: Surface expression and function.

Allergy 2019 Jan 28. Epub 2019 Jan 28.

Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Background: Siglec-7 is an inhibitory receptor (IR) expressed on human blood eosinophils. Whereas activation of other IRs, including Siglec-8 and CD300a, has been shown to downregulate eosinophil function, little is known about the role of Siglec-7 on human eosinophils.

Objective: To examine Siglec-7 expression and function in eosinophils from normal (ND) and eosinophilic (EO) donors. Read More

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http://doi.wiley.com/10.1111/all.13730
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http://dx.doi.org/10.1111/all.13730DOI Listing
January 2019
5 Reads

Hypereosinophilic syndrome presenting with bilateral ear fullness.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Jan 22. Epub 2019 Jan 22.

Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Dongguk University, Ilsan Hospital, Siksa-dong, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-773, Republic of Korea. Electronic address:

Introduction: Hypereosinophilic syndrome is a rare disease with hypereosinophilia resulting in end-organ dysfunction. Patients present with organ-associated symptoms, and the targets frequently affected are heart, lung, skin, or the nervous system, and the middle ear involvement is rare.

Case Report: A 30-year-old female with left ear fullness and hearing loss, which persisted for 6months, was finally diagnosed with hypereosinophilic syndrome (HES). Read More

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http://dx.doi.org/10.1016/j.anorl.2018.03.009DOI Listing
January 2019
2 Reads

Modulation of blood inflammatory markers by benralizumab in patients with eosinophilic airway diseases.

Respir Res 2019 Jan 18;20(1):14. Epub 2019 Jan 18.

MedImmune LLC, One MedImmune Way, #4552B, Gaithersburg, MD, USA.

Background: Benralizumab, a humanized, afucosylated, monoclonal antibody that targets interleukin-5 receptor α, depletes eosinophils and basophils by enhanced antibody-dependent cell-mediated cytotoxicity. It demonstrated efficacy for patients with moderate to severe asthma and, in a Phase IIa trial, for chronic obstructive pulmonary disease (COPD) with eosinophilic inflammation. We investigated effects of benralizumab 100 mg every 8 weeks (first three doses every 4 weeks) subcutaneous on blood inflammatory markers through proteomic and gene-expression analyses collected during two Phase II studies of patients with eosinophilic asthma and eosinophilic COPD. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-018-0968-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339432PMC
January 2019
5 Reads

Unusual manifestation of disseminated herpes simplex virus type 2 infection associated with pharyngotonsilitis, esophagitis, and hemophagocytic lymphohisitocytosis without genital involvement.

BMC Infect Dis 2019 Jan 17;19(1):65. Epub 2019 Jan 17.

Division of Rheumatology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Hon-komagome, Tokyo, 1138677, Bunkyo-ku, Japan.

Background: Herpes simplex virus (HSV) has various presentations, depending on the patient's immune status, age, and the route of transmission. In adults, HSV type 1 is found predominantly in the oral area, and HSV type 2 (HSV-2) is commonly found in the genital area. HSV-2 infection without genital lesions is uncommon. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3721-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337778PMC
January 2019
12 Reads

Serum cytokine and chemokine levels in patients with eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome, or eosinophilic asthma.

Clin Exp Rheumatol 2019 Jan 14. Epub 2019 Jan 14.

Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.

Objectives: The pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) remains poorly understood, and may overlap with eosinophilic asthma and primary hypereosinophilic syndrome (HES). The aim of this study was to analyse a panel of serum cytokines and chemokines as markers of disease activity in patients with these conditions.

Methods: The levels of 54 cytokines and chemokines were measured in the sera of 40 patients with active EGPA, 10 of these patients during inactive disease, 6 patients with HES, 8 with asthma, and 10 healthy controls. Read More

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January 2019
6 Reads

[Differential diagnosis of hypereosinophilia].

Z Rheumatol 2019 Jan 11. Epub 2019 Jan 11.

Vaskulitiszentrum-Süd, Klinik für Innere Medizin, Rheumatologie und Immunologie, Medius Kliniken, Akademisches Lehrkrankenhaus, Universität Tübingen, Kirchheim u. Teck, Deutschland.

Eosinophilia is defined as an elevated absolute number of eosinophilic leukocytes in peripheral blood or tissue. Its absolute number also defines the grade of eosinophilia. The main causes are allergic (including drug side effects) and infectious triggers but malignant and autoimmune diseases can also result in eosinophilia. Read More

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http://dx.doi.org/10.1007/s00393-018-0587-2DOI Listing
January 2019
10 Reads

[Chronic myeloid leukemia presenting with marked eosinophilia].

Rinsho Ketsueki 2018;59(12):2594-2599

Department of Hematology, Tonan Hospital.

An 80-year-old female with fever, edema in the lower extremities, and marked eosinophilia was referred to our hospital. Based on the presence of the Philadelphia chromosome, she was diagnosed with chronic myeloid leukemia (CML). Although imatinib induced a complete cytogenetic response (CCyR), CML relapsed after 28 months of starting it. Read More

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https://www.jstage.jst.go.jp/article/rinketsu/59/12/59_2594/
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http://dx.doi.org/10.11406/rinketsu.59.2594DOI Listing
January 2018
5 Reads

Chronic eosinophilic pneumonia after trastuzumab and radiation therapy for breast cancer: A case report.

Medicine (Baltimore) 2019 Jan;98(1):e14017

Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Rationale: Chronic eosinophilic pneumonia (CEP) is rare and an idiopathic disorder. The disease has been associated with drugs, infection, or irradiation, and its relationship with asthma remains unclear.

Patient Concerns: We reported a case of a 49-year-old female patient after trastuzumab and radiation therapy for breast cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000014017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344156PMC
January 2019
12 Reads

Mepolizumab as the first targeted treatment for eosinophilic granulomatosis with polyangiitis: a review of current evidence and potential place in therapy.

Ther Clin Risk Manag 2018 7;14:2385-2396. Epub 2018 Dec 7.

School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy,

Mepolizumab is an anti-interleukin-5 (IL-5) humanized monoclonal antibody that binds to free IL-5. It induces bone marrow eosinophil maturation arrest and decreases eosinophil progenitors and subsequent maturation in the blood and bronchial mucosa. Its use has been extensively studied in severe eosinophilic asthma at a dose of 100 mg subcutaneously (SC) every 4 weeks and, more recently, in other hypereosinophilic syndromes. Read More

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https://www.dovepress.com/mepolizumab-as-the-first-targeted-
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http://dx.doi.org/10.2147/TCRM.S159949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292233PMC
December 2018
14 Reads

Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia.

Leukemia 2019 Feb 20;33(2):415-425. Epub 2018 Dec 20.

Faculty of Medicine, University of Southampton, Southampton, UK.

Determining the underlying cause of persistent eosinophilia is important for effective clinical management but remains a diagnostic challenge in many cases. We identified STAT5B N642H, an established oncogenic mutation, in 27/1715 (1.6%) cases referred for investigation of eosinophilia. Read More

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http://www.nature.com/articles/s41375-018-0342-3
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http://dx.doi.org/10.1038/s41375-018-0342-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365490PMC
February 2019
10 Reads

Advances in diagnosis of mastocytosis and hypereosinophilic syndrome.

Semin Hematol 2019 01 28;56(1):22-29. Epub 2018 May 28.

Hematology Section, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892-1508.

Mastocytosis and hypereosinophilic syndrome is very rare neoplastic hematopoietic diseases. Mastocytosis is characterized by expansion and accumulation of clonal tissue mast cells in skin and/or various internal organs, while hypereosinophilic syndrome manifests with an increased number of eosinophils in the peripheral blood and tissue damage. These diseases represent a diagnostic challenge, since they can have overlapping clinical and pathologic features. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00371963183003
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http://dx.doi.org/10.1053/j.seminhematol.2018.05.005DOI Listing
January 2019
7 Reads

Hypereosinophilia: a diagnostic challenge.

Neth J Med 2018 Dec;76(10):431-436

Harbour Hospital and Institute for Tropical Diseases, Rotterdam, the Netherlands (currently working at Albert Schweitzer Hospital, Rotterdam).

Hypereosinophilia encompasses a broad differential diagnosis of atopy/allergic reactions, drug reactions, parasitic infections and paraneoplastic syndromes. Although mostly of limited clinical significance, hypereosinophilia can also be related to hematological malignancies. One has to be aware of the potential for secondary organ damage for example, in the case of hypereosinophilic syndrome. Read More

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December 2018
3 Reads

Idiopathic hypereosinophilic syndrome with cutaneous involvement: a comparative review of 32 cases.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.

Although idiopathic hypereosinophilic syndrome (HES) is uncommon, we studied the clinical characteristics of this disorder in patients with cutaneous involvement. We chronicle the case of a patient with diffuse skin rash due to idiopathic HES from our clinical experience. Furthermore, a systematic literature search of the medical databases PubMed and Google Scholar was conducted. Read More

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http://dx.doi.org/10.1136/bcr-2018-227137DOI Listing
December 2018
3 Reads

The epidemiology and clinical characteristics of myeloproliferative neoplasms in Malaysia.

Exp Hematol Oncol 2018 17;7:31. Epub 2018 Dec 17.

Department of Haematology, Sunway Medical Centre, Kuala Lumpur, Malaysia.

Background: The evolution of molecular studies in myeloproliferative neoplasms (MPN) has enlightened us the understanding of this complex disease consisting of polycythaemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). The epidemiology is well described in the western world but not in Asian countries like Malaysia.

Materials And Methods: This retrospective national registry of MPN was conducted from year 2009 to 2015 in Malaysia. Read More

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https://ehoonline.biomedcentral.com/articles/10.1186/s40164-
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http://dx.doi.org/10.1186/s40164-018-0124-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296047PMC
December 2018
43 Reads

Eosinophilia and Kidney Disease: More than Just an Incidental Finding?

J Clin Med 2018 Dec 8;7(12). Epub 2018 Dec 8.

Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, 6020 Innsbruck, Austria.

Peripheral blood eosinophilia (PBE), defined as 500 eosinophils or above per microliter (µL) blood, is a condition that is not uncommon but often neglected in the management of patients with chronic kidney disease (CKD), acute kidney injury (AKI), or patients on renal replacement therapy (RRT). The nature of PBE in the context of kidney diseases is predominantly secondary or reactive and has to be distinguished from primary eosinophilic disorders. Nonetheless, the finding of persistent PBE can be a useful clue for the differential diagnosis of underdiagnosed entities and overlapping syndromes, such as eosinophilic granulomatosis with polyangiitis (EGPA), IgG4-related disease (IgG4-RD), acute interstitial nephritis (AIN), or the hypereosinophilic syndrome (HES). Read More

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http://dx.doi.org/10.3390/jcm7120529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306805PMC
December 2018
1 Read

Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies.

J Allergy Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Md. Electronic address:

Background: Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 is selectively expressed on eosinophils, mast cells, and basophils and, when engaged on eosinophils, can cause cell death.

Objective: We sought to characterize surface and soluble Siglec-8 (sSiglec-8) levels in normal donors (NDs) and eosinophilic donors (EOs) and assess the efficacy of anti-Siglec-8 antibodies in inducing eosinophil cell death in vitro.

Methods: Eosinophil expression of Siglec-8 was assessed by using flow cytometry and quantitative PCR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183174
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http://dx.doi.org/10.1016/j.jaci.2018.10.066DOI Listing
December 2018
17 Reads
11.476 Impact Factor

Traction bronchiectasis on high-resolution computed tomography may predict fatal acute eosinophilic pneumonia.

Respir Investig 2019 Jan 24;57(1):67-72. Epub 2018 Oct 24.

Department of Respiratory Medicine, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama 710-8602, Japan.

Background: Most patients with acute eosinophilic pneumonia (AEP) show rapid improvement. However, some cases of AEP prove fatal. The aims of this study were to determine the clinical, radiographic, and pathologic characteristics of patients in whom AEP has a fatal outcome and to identify predictors of a poor prognosis. Read More

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http://dx.doi.org/10.1016/j.resinv.2018.09.005DOI Listing
January 2019
3 Reads

Hypereosinophilic syndrome: approach to treatment in the era of precision medicine.

Authors:
Amy Klion

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):326-331

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Hypereosinophilic syndromes (HESs) are a heterogeneous group of rare disorders characterized by peripheral eosinophilia and eosinophilic end organ complications. Conventional therapies, including glucocorticoids and cytotoxic and immunomodulatory agents, have variable efficacy and significant toxicity. Although the recent development of agents that target eosinophils, including tyrosine kinase inhibitors and monoclonal antibodies, provides the possibility of more effective, less toxic approaches to treatment of HES, there are little available data to guide their use in these conditions. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245960PMC
November 2018
2 Reads

Thrombosis in the portal venous system caused by hypereosinophilic syndrome: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13425

Department of Critical Care Medicine, Nantong Third People's Hospital, Nantong University.

Rationale: Extensive thrombosis in the portal venous system caused by hypereosinophilic syndrome (HES) is rare, and there is no consensus on anticoagulant and thrombolytic treatments for arteriovenous thrombosis caused by HES.

Patient Concerns: The clinical data of a patient with extensive thrombosis in his portal venous system (superior mesenteric, splenic, hepatic, and portal veins), renal artery thrombosis, and mesenteric thrombosis caused by HES with secondary gastrointestinal bleeding and intestinal necrosis were retrospectively analyzed. Before admission, his eosinophil count increased to 7. Read More

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http://dx.doi.org/10.1097/MD.0000000000013425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283207PMC
November 2018
19 Reads

What Are the Clinical Features and Etiology of Eosinophilic Liver Infiltration?

Gut Liver 2019 03;13(2):183-190

Gastroenterology, Department of Internal Medicine, Gwangju, Korea.

Background/aims: Although eosinophilic liver infiltration (ELI) is not rare, few data exist regarding its clinical characteristics and etiology. Therefore, we evaluated these aspects to better understand the clinical implications of this lesion type, which is reasonably common in Korea.

Methods: Patients suspected of having ELI, based on abdominal computed tomography results obtained between January 2010 and September 2017, were enrolled in this retrospective study. Read More

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http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl18
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http://dx.doi.org/10.5009/gnl18266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430429PMC
March 2019
19 Reads

[Vasculitides and eosinophilic pulmonary diseases].

Z Rheumatol 2018 Dec;77(10):907-922

Abt. für Rheumatologie, Immunologie und Rehabilitation, Kantonsspital St. Gallen, St. Gallen, Schweiz.

Eosinophilic granulocytes form peripheral effector cells controlled by Th2 lymphocytes, which cause local cell, tissue, and functional disorders of infiltrated organs via the release of cytotoxic basic proteins and oxygen radicals. Diseases associated with eosinophilia include systemic and organ-related forms. The lungs are involved in eosinophilic granulomatosis with polyangiitis (EGPA, formerly known as Churg-Strauss syndrome), acute and chronic eosinophilic pneumonia, as well as in an organ manifestation in hypereosinophilic syndrome and certain parasitic diseases. Read More

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http://link.springer.com/10.1007/s00393-018-0561-z
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http://dx.doi.org/10.1007/s00393-018-0561-zDOI Listing
December 2018
18 Reads

Diagnosis of systemic lupus erythematosus by presence of Hargraves cells in eosinophilic pleural effusion: Case report.

Medicine (Baltimore) 2018 Oct;97(42):e12871

Department of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland.

Rationale: Eosinophilic pleural effusion in elderly patients is most commonly due to malignancies and infections.

Patient Concerns: In rare cases, pleural eosinophilia is associated with connective tissue disease.

Diagnoses: Presence of Hargraves cells, also called lupus erythematosus (LE) cells (polynuclear cells that have engulfed denatured nuclear material), was a key point of American College of Rheumatology (ACR) classification criteria for systemic lupus erythematosus (SLE) until 1997. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810190-0006
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http://dx.doi.org/10.1097/MD.0000000000012871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211931PMC
October 2018
7 Reads

Indeterminate dendritic cell neoplasm accompanied by eosinophilic pneumonia successfully treated by systemic steroid therapy: Report of the first case with muscular and parotid involvement and review of published work.

J Dermatol 2018 Dec 15;45(12):1444-1447. Epub 2018 Oct 15.

Department of Dermatology, Kansai Medical University Medical Center, Osaka, Japan.

A 34-year-old Japanese man presented with an indolent nodule on the right flank. Computed tomography of the chest and abdomen demonstrated a large nodule measuring 55 mm × 50 mm in the abdominal oblique muscle layer of the right flank, and several small nodules were seen in the muscle layer throughout the body and subcutaneous tissue of the lower abdomen. F-fluorodeoxyglucose-positron emission tomography/computed tomography revealed nodular lesions in the bilateral parotid glands, bilateral cervical lymph nodes and lower lobe of the right lung. Read More

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http://dx.doi.org/10.1111/1346-8138.14673DOI Listing
December 2018
14 Reads

Longitudinal stability of blood eosinophil count strata in the COPD COSYCONET cohort.

Int J Chron Obstruct Pulmon Dis 2018 28;13:2999-3002. Epub 2018 Sep 28.

Pulmonary Research Institute at Lungen Clinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Centre for Lung Research (DZL), Grosshansdorf, Germany.

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https://www.dovepress.com/longitudinal-stability-of-blood-eo
Publisher Site
http://dx.doi.org/10.2147/COPD.S165909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168004PMC
March 2019
4 Reads

C-Reactive protein as a diagnostic tool in differential diagnosis of hypereosinophilic syndrome and antineutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis.

J Allergy Clin Immunol Pract 2019 Apr 11;7(4):1347-1351.e3. Epub 2018 Oct 11.

CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Auto-immunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), University of Lille, Lille, France; Centre de Référence National des Syndromes Hyperéosinophiliques (CEREO), France; CHU Lille, Institut d'Immunologie, University of Lille, Lille, France; Inserm, CHU Lille, U995 - LIRIC - Lille Inflammation Research International Center, University of Lille, Lille, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132198183065
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http://dx.doi.org/10.1016/j.jaip.2018.10.002DOI Listing
April 2019
20 Reads

Reflux aspiration in lungs of dogs with respiratory disease and in healthy West Highland White Terriers.

J Vet Intern Med 2018 Nov 12;32(6):2074-2081. Epub 2018 Oct 12.

Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Finland.

Background: Gastroesophageal reflux and microaspiration (MA) of gastric juice are associated with various human respiratory diseases but not in dogs.

Objective: To detect the presence of bile acids in bronchoalveolar lavage fluid (BALF) of dogs with various respiratory diseases.

Animals: Twenty-seven West Highland White Terriers (WHWTs) with canine idiopathic pulmonary fibrosis (CIPF), 11 dogs with bacterial pneumonia (BP), 13 with chronic bronchitis (CB), 9 with eosinophilic bronchopneumopathy (EBP), 19 with laryngeal dysfunction (LD), 8 Irish Wolfhounds (IWHs) with previous BPs, 13 healthy WHWTs, all privately owned dogs, and 6 healthy research colony Beagles METHODS: Prospective cross-sectional observational study with convenience sampling of dogs. Read More

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http://dx.doi.org/10.1111/jvim.15321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271311PMC
November 2018
5 Reads

Case report of hypereosinophilic syndrome presenting as severe ischaemic colitis.

ANZ J Surg 2018 Oct 2. Epub 2018 Oct 2.

Acute Surgical Unit, Division of Surgery, Logan Hospital, Logan City, Queensland, Australia.

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http://dx.doi.org/10.1111/ans.14894DOI Listing
October 2018
4 Reads

Cough in the Immunosuppressed Patient.

Gastroenterology 2019 03 27;156(4):e3-e4. Epub 2018 Sep 27.

Departmetn of Gastroenterology, Royal Melbourne Hospital, Fitzroy, Victoria, Australia.

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http://dx.doi.org/10.1053/j.gastro.2018.09.044DOI Listing
March 2019
3 Reads

Omalizumab therapy in a patient with cronic spontaneous urticaria, ulcerative colitis, hypereosinophilia and prurigo Besnier: a case report.

J Dermatolog Treat 2018 ;29(sup3):10-13

a Dermatologic Clinic Sapienza University of Rome , Rome , Italy.

The case of a woman who suffered from CSU and prurigo Besnier, with a history of chronic hyper-eosinophilia, ulcerative colitis and thyroiditis, unresponsive to anti-histamines and steroids is reported. The patient received omalizumab treatment, and obtained resolution of urticaria along with improvement of cutaneous symptoms of prurigo. Read More

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http://dx.doi.org/10.1080/09546634.2018.1527990DOI Listing
January 2019
6 Reads

A rare case of hypereosinophilic syndrome presenting with unilateral proptosis and torticollis.

Indian J Ophthalmol 2018 Oct;66(10):1508-1511

Department of Oculoplasty, Sri Sankaradeva Nethralaya, Guwahati, Assam, India.

Hypereosinophilic syndrome (HES) is a spectrum of myeloproliferative disorder, which is characterized by persistent and marked blood eosinophilia and damage to multiple organs due to eosinophilic infiltration. Idiopathic HES is identified after ruling out all other causes of eosinophilia. Poor prognosis is usually associated with cardiac involvement and malignant transformation of blood cells. Read More

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http://dx.doi.org/10.4103/ijo.IJO_316_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173005PMC
October 2018
19 Reads

Acute pulmonary embolism and deep vein thrombosis secondary to idiopathic hypereosinophilic syndrome.

Respir Med Case Rep 2018 10;25:213-215. Epub 2018 Sep 10.

Department of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Acute pulmonary embolism (PE) is a most dangerous complication that needs prompt treatment to reduce potentially death. There are many well-known prognostic factors indicate the morbidity and mortality in various thromboembolic events. Persistent eosinophilia in peripheral blood can lead to tissue infiltration and even organ damage, but the urgent event of thromboembolism in pulmonary provoked by eosinophil eosinophilia in idiopathic hypereosinophilic syndrome (HES) is relative an unusual presentation. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143698PMC
September 2018
9 Reads

Eosinophilic Granulomatosis with Polyangiitis: Clinical Pathology Conference and Review.

J Allergy Clin Immunol Pract 2018 Sep - Oct;6(5):1496-1504

UNC Kidney Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Eosinophilic granulomatosis with polyangiitis (EGPA) (formerly Churg-Strauss syndrome) is a small vessel vasculitis associated with asthma and eosinophilia. Despite its rarity, continuous gains are being made in understanding the disease with knowledge advancements regarding its epidemiology, heterogeneous clinical manifestations, management, and outcomes. Large knowledge gaps remain, however, particularly surrounding pathophysiologic and diagnostic uncertainties. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.07.001DOI Listing
May 2018
15 Reads

Eosinophils: Friends or Foes?

Authors:
Michael J Chusid

J Allergy Clin Immunol Pract 2018 Sep - Oct;6(5):1439-1444

Section of Pediatric Infectious Diseases, Medical College of Wisconsin, Milwaukee, Wis. Electronic address:

The roles eosinophils are recognized to play in health and disease continue to evolve. Formerly, eosinophils were believed to fill a primary role in host defense against helminths, an intermediary one in the propagation of allergic conditions, and a pathologic one in clinical conditions characterized by systemic eosinophilia and eosinophilic infiltration of target organs. Eosinophils are increasingly understood to be positioned centrally within mammalian immune and inflammatory networks, possessing receptors for an array of inflammatory mediators and capable of producing numerous proinflammatory and homeostatic mediators. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.04.031DOI Listing
February 2018
3 Reads