2,129 results match your criteria Hyperemesis Gravidarum


Rating of four different foods in women with hyperemesis gravidarum: a randomised controlled trial.

BMJ Open 2021 May 13;11(5):e046528. Epub 2021 May 13.

Obstetrics and Gynaecology, University of Malaya, Kuala Lumpur, Malaysia.

Objective: To evaluate four foods in women with hyperemesis gravidarum (HG) on their agreeability and tolerability.

Design: Prospective, randomised, within-subject cross-over trial.

Setting: Single-centre, tertiary, university hospital in Malaysia. Read More

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Pregnant women report being denied medications to treat severe nausea and vomiting of pregnancy or hyperemesis gravidarum - findings from an Australian online survey.

Aust N Z J Obstet Gynaecol 2021 May 13. Epub 2021 May 13.

SA Pharmacy, Flinders Medical Centre, SA Health, Adelaide, South Australia, Australia.

We conducted an online survey of 249 Australian women who currently or previously experienced severe nausea and vomiting of pregnancy (NVP) or hyperemesis gravidarum (HG) and examined their experiences in being denied medications during pregnancy. One in four women reported being denied medications for NVP/HG, which most commonly involved doxylamine and encounters with community pharmacists. Women's experiences reflected that lack of awareness of guidelines and unfavourable risk-benefit assessments appeared to be key barriers to facilitating medication access. Read More

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Life-threatening complications of hyperemesis gravidarum.

Exp Ther Med 2021 Jun 16;21(6):642. Epub 2021 Apr 16.

Department of Neurology, 'Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca 400012, Romania.

Hyperemesis gravidarum (HG) refers to severe nausea and emesis noted during pregnancy. However, no consensus exists on the specific diagnostic criteria that can be used for this condition. The aim of the present systematic review was to summarize the available evidence regarding the severe complications observed during HG with a heightened risk of fatality. Read More

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Hyperemesis gravidarum and neonatal outcomes: A systematic review of observational studies.

Taiwan J Obstet Gynecol 2021 May;60(3):422-432

Department of Midwifery, University of West Attica, Athens, Greece.

Hyperemesis gravidarum (HG) is associated with adverse somatic and psychological effects. The impact of HG on neonatal outcomes is debatable given that disagreeing research results have appeared. The objective of this study was to systematically review, according to the PRISMA guidelines, and synthesize the available evidence from observational studies on the relationship between HG and neonatal outcomes. Read More

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Hyperemesis gravidarum induced refeeding syndrome causes blood cell destruction: a case report and literature review.

BMC Pregnancy Childbirth 2021 May 9;21(1):366. Epub 2021 May 9.

Department of Obstetrics Gynecology, Cheeloo College of Medicine, Qilu Hospital, Shandong University, Shandong, 250012, Jinan, China.

Background: Hyperemesis gravidarum (HG) is a common complication during pregnancy, however, HG associated simultaneous onset of blood cell destruction due to electrolyte abnormalities is rare. In this case, a woman with refeeding syndrome (RFS) secondary to electrolyte abnormalities caused by severe HG was diagnosed and managed in our hospital.

Case Presentation: A 29-year old woman was sent to the local hospitals because of severe HG with appetite loss, weight reduction, general fatigue, and she was identified to have severe electrolyte abnormalities. Read More

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Dietary fibre intake and lifestyle characteristics in relation to nausea or vomiting during pregnancy-a questionnaire-based cohort study.

J Obstet Gynaecol 2021 May 4:1-8. Epub 2021 May 4.

School of Health Sciences, Tampere Research and Innovation Center and University of Tampere, Tampere University Hospital, Tampere, Finland.

Nausea or vomiting in pregnancy (NVP) are among the commonest symptoms experienced in early pregnancy. We wanted to evaluate the association of dietary fibre intake, lifestyle characteristics and bowel function with NVP. One hundred and eighty-eight participants completed a self-administered questionnaire concerning bowel function, dietary fibre intake and lifestyle characteristics. Read More

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Intravenous Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC): A Randomized, Controlled Trial.

Ann Emerg Med 2021 05;77(5):555

Department of Emergency Medicine, McGill University, Montreal, Quebec, Canada, Centre Antipoison du Québec, Québec, Quebec, Canada.

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Original article: is the protective association between hyperemesis gravidarum and birth defects biased by pregnancy termination?

Ann Epidemiol 2021 Mar 30;59:10-15. Epub 2021 Mar 30.

Institut national de santé publique du Québec, Montreal, QC, Canada; University of Montreal Hospital Research Centre, Montreal, QC, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, QC, Canada. Electronic address:

Purpose: We assessed whether the protective association between hyperemesis gravidarum and birth defects could be due to selection bias from exclusion of pregnancy terminations.

Methods: We designed a cohort study of 2,115,581 live births in Canada, 1990-2016. The main exposure measure was hyperemesis gravidarum. Read More

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Wernicke-Korsakoff Syndrome in Hyperemesis Gravidarum: A Case Report and Literature Review.

Neurohospitalist 2021 Apr 4;11(2):141-147. Epub 2020 Sep 4.

Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Philippines.

Background: Wernicke-Korsakoff syndrome (WKS) is a triad of ophthalmoplegia, ataxia and memory deficits due to thiamine insufficiency resulting from under- or untreated Wernicke's encephalopathy (WE), which may be associated with hyperemesis gravidarum (HEG).

Case Presentation: We present a case of a 36-year-old Filipino woman in her first trimester with HEG, along with the WKS triad and abnormal hyperintense signals in the bilateral thalami and midbrain, left occipital lobe, periaqueductal gray matter and pontine periventricular areas. Neurologic deficits partially improved but persisted despite intravenous thiamine administration. Read More

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Deranged liver function in pregnancy.

BMJ 2021 03 31;372:n645. Epub 2021 Mar 31.

Guy's and St Thomas' Hospital NHS Trust, St Thomas' Hospital, London, UK.

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Health outcomes of smoking during pregnancy and the postpartum period: an umbrella review.

BMC Pregnancy Childbirth 2021 Mar 26;21(1):254. Epub 2021 Mar 26.

Health Economics Unit, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Background: Smoking during pregnancy (SDP) and the postpartum period has serious health outcomes for the mother and infant. Although some systematic reviews have shown the impact of maternal SDP on particular conditions, a systematic review examining the overall health outcomes has not been published. Hence, this paper aimed to conduct an umbrella review on this issue. Read More

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Recurring vomiting, skin discolouration: the easily overlooked thermal element of cannabinoid hyperemesis syndrome.

BMJ Case Rep 2021 Mar 24;14(3). Epub 2021 Mar 24.

Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, Florida, USA.

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Clinicobiochemical Parameters and Predictors of Liver Disease in Hospitalized Asian Indian Pregnant Women in a Tertiary Care Center in Northern India.

Cureus 2021 Feb 17;13(2):e13405. Epub 2021 Feb 17.

Medicine, C U Shah Medical College, Surendranagar, IND.

Introduction  During pregnancy, liver dysfunction is more frequent than expected and may require specialized care. For the early diagnosis, it is important to determine if changes in liver physiology may develop into liver disease. Liver disease during pregnancy may require intervention from a hepatologist for adequate monitoring of mother-fetus health outcomes. Read More

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February 2021

The association between quality of life and complementary and alternative medicine use in pregnant women with hyperemesis gravidarum.

J Obstet Gynaecol Res 2021 Mar 22. Epub 2021 Mar 22.

Nursing Department, Ankara Yıldırım Beyazıt University Faculty of Health Sciences, Ankara, Turkey.

Aim: This study investigated the association between quality of life and complementary and alternative medicine (CAM) use in pregnant women with hyperemesis gravidarum in Turkey.

Methods: This cross-sectional descriptive study was conducted between October 2017 and July 2018 in Turkey. The sample consisted of 240 pregnant women with hyperemesis gravidarum. Read More

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Wernicke's encephalopathy post hyperemesis gravidarum misdiagnosed as Guillain-Barre syndrome: lessons for the frontline.

BMJ Case Rep 2021 Mar 16;14(3). Epub 2021 Mar 16.

Medicine, Kasturba Medical College Mangalore, Mangalore, India.

We report a case of a 26-year-old pregnant woman, who presented with subacute limb weakness. This was initially suspected to be Guillain-Barre syndrome but subsequently found to be the motor neuropathy of dry beriberi (vitamin B1, thiamine deficiency) along with associated Wernicke's encephalopathy (WE). The underlying cause was revealed as hyperemesis gravidarum (HG). Read More

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Predictors of adverse pregnancy outcome at Hospitals in South Gondar Zone, North-central Ethiopia: A multicenter facility-based unmatched case-control study.

Heliyon 2021 Feb 22;7(2):e06323. Epub 2021 Feb 22.

Department of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.

Background: Adverse pregnancy outcomes are the most significant public health problem which leads to serious short and long-term health consequences to the mother and the newborn baby. Adverse pregnancy outcomes, especially prematurity and low birth weights are the major cause of neonatal morbidity and mortality in Ethiopia, particularly in the study area. Therefore, this study was aimed to determine predictors of adverse pregnancy outcome among mothers who gave birth at Hospitals in South Gondar zone, North-central Ethiopia. Read More

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February 2021

Antiemetic Prescription Fills in Pregnancy: A Drug Utilization Study Among 762,437 Pregnancies in Norway.

Clin Epidemiol 2021 26;13:161-174. Epub 2021 Feb 26.

PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy, and PharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.

Objective: To determine antiemetic prescription fill patterns during pregnancy in Norway, with special focus on the use of ondansetron and recurrent use in subsequent pregnancies.

Methods: We conducted a population-based registry study based on data from the Medical Birth Registry of Norway linked to the Norwegian Prescription Database for 762,437 pregnancies >12 gestational weeks ending in live or non-live births between 2005 and 2017. Prescription fills of medications used for nausea and vomiting of pregnancy were summarized in treatment pathways to determine drug utilization patterns. Read More

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February 2021

Thyroid-stimulating hormone and free thyroxine fail to predict the severity and clinical course of hyperemesis gravidarum: A prospective cohort study.

Acta Obstet Gynecol Scand 2021 Feb 19. Epub 2021 Feb 19.

Department of Obstetrics and Gynecology, Amsterdam Reproduction & Development research institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

Introduction: Little is known about the pathophysiology of hyperemesis gravidarum (HG). Proposed underlying causes are multifactorial and thyroid function is hypothesized to be causally involved. In this study, we aimed to assess the utility of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) as a marker and predictor for the severity and clinical course of HG. Read More

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February 2021

Olfactory dysfunction and oxidative stress in pregnant women with hyperemesis gravidarum.

Arch Gynecol Obstet 2021 Feb 16. Epub 2021 Feb 16.

Adana Ortadoğu Hospital, ENT Clinics, Adana, Turkey.

Purpose: This study aimed to compare the first-trimester pregnancy serum total oxidative status (TOS), total antioxidant status (TAS), and serum estradiol levels as well as the olfactory functions assessed using the brief smell identification test (BSIT) of women with healthy pregnancies and those with hyperemesis gravidarum (HG).

Methods: In this prospective study, 60 pregnant women in the first trimester of their pregnancies were divided into two groups: 30 pregnant women with HG (study group) and 30 healthy pregnant women (control group). The following parameters were compared in the HG group and the healthy controls: TOS, TAS, serum levels of estradiol (E2), and olfactory function, which was measured using BSIT. Read More

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February 2021

Prenatal health of immigrant women in Norway - an exploratory literature review.

Tidsskr Nor Laegeforen 2021 Feb 1;141(2). Epub 2021 Feb 1.

Background: Immigrant women are a vulnerable group within Norwegian prenatal care and have an increased risk of adverse pregnancy outcomes. The purpose of this exploratory literature review was to compile an overview of the available knowledge on the prenatal health of immigrant women in Norway.

Evidence Base: The literature review covers 44 peer-reviewed articles on the prenatal health of immigrant women in Norway. Read More

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February 2021

Reply to: post-emesis periorbital purpura in hyperemesis gravidarum.

Int J Dermatol 2021 06 1;60(6):e244-e246. Epub 2021 Feb 1.

Department of Dermatology, Lozano Blesa University Clinical Hospital, Zaragoza, Spain.

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The use of cannabis for Hyperemesis Gravidarum (HG).

J Cannabis Res 2020 Jan 30;2(1). Epub 2020 Jan 30.

Adelson Faculty of Medicine, Ariel University, 40700, Ariel, Israel.

Background: Hyperemesis Gravidarum (HG) responds only partially to standard antiemetic medications. Cannabis has been known to possess antiemetic effects and there are several medicinal cannabinoids used as anti -emetics for cancer chemotherapy. Its favorable use for HG has been described in social media, but not in the medical literature. Read More

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January 2020

Central nervous system solitary fibrous tumour/hemangiopericytoma presenting as nausea, vomiting and hepatic dysfunction after the first trimester of pregnancy: A case report.

Case Rep Womens Health 2021 Jan 12;29:e00285. Epub 2021 Jan 12.

Department of Gynaecology and Obstetrics, the First Affiliated Hospital of Xinxiang Medical University, Henan, China.

Background: Solitary fibrous tumour/haemangiopericytoma (SFT-HPC) is a rare fibroblastic mesenchymal neoplasm that develops as a result of the uncontrolled proliferation of mesenchymal fibroblasts and occurs rarely during pregnancy.

Case Presentation: A 26-year-old woman (GP) with an intrauterine pregnancy at 34weeks presented at a university hospital with a history of nausea and vomiting since 20 weeks. Other symptoms included slight headache and 5-kg weight loss. Read More

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January 2021

HyperEmesis Level Prediction (HELP Score) Identifies Patients with Indicators of Severe Disease: a Validation Study.

Geburtshilfe Frauenheilkd 2021 Jan 19;81(1):90-98. Epub 2021 Jan 19.

Keck School of Medicine, University of Southern California, Department of Maternal-Fetal Medicine, Los Angeles, CA, USA.

Hyperemesis gravidarum (HG) severity can be underestimated resulting in undertreatment and adverse outcomes. This study was conducted to validate a tool (HELP Score) designed to score HG severity. A survey link which included PUQE and HELP Score (HELP) tool questions was posted on websites related to HG. Read More

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January 2021

A patient-clinician James Lind Alliance partnership to identify research priorities for hyperemesis gravidarum.

BMJ Open 2021 01 15;11(1):e041254. Epub 2021 Jan 15.

Obstetrics and Gynecology, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, The Netherlands.

Objective: There are many uncertainties surrounding the aetiology, treatment and sequelae of hyperemesis gravidarum (HG). Prioritising research questions could reduce research waste, helping researchers and funders direct attention to those questions which most urgently need addressing. The HG priority setting partnership (PSP) was established to identify and rank the top 25 priority research questions important to both patients and clinicians. Read More

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January 2021

Effect of gabapentin on hyperemesis gravidarum: a double-blind, randomized controlled trial.

Am J Obstet Gynecol MFM 2021 01 29;3(1):100273. Epub 2020 Oct 29.

Department of Obstetrics and Gynecology, University of Rochester, Rochester, NY.

Background: Hyperemesis gravidarum is a disabling disease of nausea, vomiting, and undernutrition in early pregnancy for which there are no effective outpatient therapies. Poor weight gain in hyperemesis gravidarum is associated with several adverse fetal outcomes including preterm delivery, low birthweight, small for gestational age, low 5-minute Apgar scores, and neurodevelopmental delay. Gabapentin is most commonly used clinically for treating neuropathic pain but also substantially reduces chemotherapy-induced and postoperative nausea and vomiting. Read More

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January 2021

Nutritional challenges of gastric cancer patients from the perspectives of patients, family caregivers, and health professionals: a qualitative study.

Support Care Cancer 2021 Jan 3. Epub 2021 Jan 3.

Omid Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Purpose: This study aims to explore the perceptions of gastric cancer patients, their family caregivers, physicians, and nurses of nutritional challenges.

Methods: Using a descriptive qualitative method, this study was conducted in 2019-2020. Twenty participants (6 patients, 6 family caregivers, 3 physicians, and 5 nurses) were selected through purposive sampling. Read More

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January 2021

Gout in Pregnancy: A Rare Phenomenon.

Cureus 2020 Nov 25;12(11):e11697. Epub 2020 Nov 25.

Internal Medicine, University of Florida College of Medicine, Jacksonville, USA.

Gout is a rare phenomenon in reproductive age women due to the uricosuric effects of estrogen. Furthermore, gout in pregnancy has been reported in only a scant number of case reports. We present the case of a 21-year-old gravida-4 para-3 female at four-weeks gestation presenting with acute polyarticular gout, complicated by Haemophilus influenzae sepsis and hyperemesis gravidarum. Read More

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November 2020

Diagnosing and managing adrenal crisis in pregnancy: A case report.

Case Rep Womens Health 2021 Jan 10;29:e00278. Epub 2020 Dec 10.

Walter Reed National Military Medical Center, Department of Obstetrics & Gynecology, United States of America.

Background: The diagnosis of adrenal insufficiency in pregnancy is relatively rare. Further, making this diagnosis can be challenging as many of the symptoms overlap with normal symptoms of pregnancy. Given the potential for severe maternal and fetal morbidity and mortality, early recognition and prompt comprehensive treatment are critical. Read More

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January 2021