2,272 results match your criteria Hyperemesis Gravidarum


Management of severe pregnancy sickness and hyperemesis gravidarum.

BMJ 2018 Nov 30;363:k5000. Epub 2018 Nov 30.

Amsterdam UMC, University of Amsterdam, Obstetrics and Gynaecology, Amsterdam, The Netherlands.

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November 2018

Patient Preferences and Experiences in Hyperemesis Gravidarum Treatment: A Qualitative Study.

J Pregnancy 2018 30;2018:5378502. Epub 2018 Oct 30.

Department of Obstetrics and Gynaecology, University Medical Centers Amsterdam, University of Amsterdam, Amsterdam, Netherlands.

Introduction: Hyperemesis gravidarum (HG) medical therapies are currently of limited effect, which creates a larger role for patient preferences in the way HG care is arranged. This is the first study using in-depth interviews to investigate patients' preferences and experiences of HG treatment.

Materials And Methods: We conducted individual in-depth interviews among women who had been hospitalized for HG in North Holland at least once in the past 4 years. Read More

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October 2018
4 Reads

Under-recognized Etiology of Altered Mental Status in a Patient with Alcoholism.

Clin Pract Cases Emerg Med 2018 Nov 16;2(4):341-343. Epub 2018 Oct 16.

Beaumont Health System, Department of Emergency Medicine, Royal Oak, Michigan.

Wernicke's encephalopathy is an important condition for the emergency physician (EP) to consider in patients at risk for malnutrition. A 60-year-old man with history of alcoholism presented with word-finding difficulties, dysmetria, ataxia, and personality changes. After treatment with high-dose thiamine, his neurological status returned to his baseline. Read More

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November 2018
2 Reads

Recent Trends in Cyclic Vomiting Syndrome - Associated Hospitalizations with Liberalization of Cannabis Use in the State of Colorado.

Intern Med J 2018 Nov 13. Epub 2018 Nov 13.

Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI, USA.

Background: Currently 29 states in the United States along with the District of Columbia have legalized cannabis in some forms. There is a paucity of data on the impact of legalization of cannabis use on hospitalizations due to cyclic vomiting syndrome (CVS).

Aim: To study the trends in CVS-related hospitalizations and cannabis use in CVS in relation to legalization of recreational cannabis use in Colorado. Read More

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November 2018
5 Reads

What Is Cannabinoid Hyperemesis Syndrome?

J Emerg Nurs 2018 Nov;44(6):665-667

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November 2018
4 Reads

Evaluation of Patients with Suspected Gastroparesis.

Gastrointest Endosc Clin N Am 2019 Jan 11;29(1):39-54. Epub 2018 Sep 11.

Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic College of Medicine and Science, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address:

There is substantial overlap between the symptoms of gastroparesis and a variety of alternative disorders. These conditions include rumination syndrome, drug-induced gastric emptying delay, cannabinoid hyperemesis syndrome, and eating disorders, which can be identified based on the history alone. The remaining patients require a diagnostic approach of physical examination, laboratory tests, evaluation with esophagogastroduodenoscopy or contrast radiography, and a test to measure gastric emptying. Read More

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January 2019
2 Reads

Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: A nested case-control study.

Wellcome Open Res 2018 21;3:123. Epub 2018 Sep 21.

Metabolic Research Laboratories and MRC Metabolic Diseases Unit, University of Cambridge Addenbrooke's Hospital Cambridge, Cambridge, CB2 0QQ, UK.

Although nausea and vomiting are very common in pregnancy, their pathogenesis is poorly understood. We tested the hypothesis that circulating growth and differentiation factor 15 (GDF15) concentrations in early pregnancy, whose gene is implicated in hyperemesis gravidarum, are associated with nausea and vomiting. Blood samples for the measurement of GDF15 and human chorionic gonadotrophin (hCG) concentrations were obtained early in the second trimester (median 15. Read More

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September 2018
2 Reads

[PR-EMPTIVE TREATMENT FOR HYPEREMESIS GRAVIDARUM].

Harefuah 2018 Oct;157(10):638-639

Motherisk Israel, Clinical Pharmacology Unit, Assaf Harofe Hospital.

Background: Hyperemesis gravidarum (HG) affects around 1% of pregnant women. The experience is traumatic, and many women hesitate to start a subsequent pregnancy in view of the tendency of HG to re-occur.

Objectives: A 25 year old woman who experienced HG in her previous pregnancy was very afraid to start a second pregnancy, as she considered the termination of the first, traumatic pregnancy. Read More

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October 2018
1 Read

BET 1: Haloperidol in cannabinoid hyperemesis syndrome.

Emerg Med J 2018 Nov;35(11):711-712

Emergency Medicine, McMaster University, Ontario, Canada.

A short-cut review was carried out to establish whether haloperidol is effective at treating the symptoms of cannabinoid hyperemesis syndrome (CHS). One study was directly relevant to the question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of that paper were tabulated. Read More

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November 2018

Hyperemesis Gravidarum.

Nutr Clin Pract 2018 Oct 18. Epub 2018 Oct 18.

Department of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Nausea and vomiting of pregnancy affect the majority of pregnancies, while the most severe version, hyperemesis gravidarum (HG), affects a much smaller subset of women. Despite the prevalence of nausea and vomiting of pregnancy and the severe consequences of HG, the pathophysiology of these conditions is not fully understood. Currently, it is thought that a combination of hormonal factors accounts for their development. Read More

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October 2018
1 Read

Cannabis hyperemesis syndrome.

Authors:
Umesh Sharma

BMJ Case Rep 2018 Oct 14;2018. Epub 2018 Oct 14.

Community Division of Hospital Medicine, Mayo Clinic Health System, Rochester, Minnesota, USA.

A young woman with chronic cannabis use presents with 2-day history of cyclical nausea, vomiting and abdominal pain. Clinical and laboratory examination excluded other causes. Patient's symptoms improved with topical capsaicin, hot showers, antiemetics and she was subsequently discharged home 4 days later. Read More

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October 2018

Recurrent Nausea and Vomiting in a Pregnant Woman with Chronic Marijuana Use.

Case Rep Obstet Gynecol 2018 16;2018:9746062. Epub 2018 Sep 16.

Texas Tech University Health Sciences Center, School of Medicine, Department of Obstetrics and Gynecology, 1400 South Coulter Street, Amarillo, TX 79106, USA.

Background: Cannabinoid hyperemesis syndrome is a condition characterized by chronic cannabis use and cyclic episodes of nausea, vomiting, and abdominal pain, relieved by compulsive bathing. The syndrome is likely to be underdiagnosed in pregnant women due to its similarity with hyperemesis gravidarum in the presentation.

Case: We report a 20-year-old pregnant woman with multiple admissions for recurrent nausea and vomiting who was observed to be taking frequent hot showers. Read More

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September 2018
2 Reads

Mirtazapine for Major Depression Developed After Hyperemesis Gravidarum.

Authors:
Ahmed Naguy

Am J Ther 2018 Sep 18. Epub 2018 Sep 18.

Al-Manara Centre, Kuwait Centre for Mental Health (KCMH), Kuwait City, Kuwait.

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September 2018
2 Reads
1.130 Impact Factor

Atypical presentation of molar pregnancy.

BMJ Case Rep 2018 Sep 27;2018. Epub 2018 Sep 27.

Department of Obstetrics and Gynaecology, Our Lady of Lourdes Hospital, Drogheda, Ireland.

The classic features of molar pregnancy are irregular vaginal bleeding, hyperemesis, enlarged uterus for gestational age and early failed pregnancy. Less common presentations include hyperthyroidism, early onset pre-eclampsia or abdominal distension due to theca lutein cysts. Here, we present a case of molar pregnancy where a woman presented to the emergency department with symptoms of acute abdomen and was treated as ruptured ectopic pregnancy. Read More

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September 2018
2 Reads

Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum.

Geburtshilfe Frauenheilkd 2018 Sep 14;78(9):866-870. Epub 2018 Sep 14.

Department of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Hyperemesis gravidarum (HG), a pregnancy complication characterized by severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies. It is associated with both maternal and fetal morbidity. HG is highly heritable and recurs in approximately 80% of women. Read More

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September 2018
1 Read

Assessment of discharge treatment prescribed to women admitted to hospital for hyperemesis gravidarum.

Int J Clin Pract 2018 Sep 21:e13261. Epub 2018 Sep 21.

Division of Epidemiology & Public Health, City Hospital, University of Nottingham, Nottingham, UK.

Aims: Prescribing drug treatment for the management of hyperemesis gravidarum (HG), the most severe form of nausea and vomiting in pregnancy, remains controversial. Since most manufacturers do not recommend prescribing antiemetics during pregnancy, little is known regarding which treatments are most prevalent among pregnant patients. Here, we report for the first time, evidence of actual treatments prescribed in English hospitals. Read More

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September 2018
4 Reads
2.570 Impact Factor

Wernicke Encephalopathy Due to Hyperemesis Gravidarum in Pregnancy: A Case Report.

Cureus 2018 Jul 17;10(7):e2991. Epub 2018 Jul 17.

Surgery, Jinnah Postgraduate Medical Centre, Karachi, PAK.

Wernicke's encephalopathy (WE) is a life-threatening acute or sub-acute neurological emergency characterized by ataxia, confusion, nystagmus, and ophthalmoparesis caused by thiamine deficiency. It was first described in 1881 by Carl Wernicke with alcohol being the most common cause. We present a rare case of a 35-year-old pregnant female who presented to our emergency department with a history of vomiting and loose motions for two weeks. Read More

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July 2018
1 Read

Optimisation of hyperemesis gravidarum management through an emergency department setting.

BMJ Open Qual 2018 8;7(3):e000330. Epub 2018 Sep 8.

Emergency Department, Princess Royal University Hospital, Orpington, Kent, UK.

Hyperemesis gravidarum is a common condition characterised by severe nausea and vomiting. The referral process from the emergency department (ED) to obstetrics and gynaecology (O&G) can lead to treatment delays before the gynaecology team review the patient, resulting in unnecessary prolonged inpatient stays in O&G. This quality improvement project created a clinical pathway which optimised care of patients presenting with hyperemesis gravidarum in the ED at the Princess Royal University Hospital using a treatment protocol. Read More

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September 2018
2 Reads

The association between the degree of nausea in pregnancy and subsequent posttraumatic stress.

Arch Womens Ment Health 2018 Sep 17. Epub 2018 Sep 17.

Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway.

Hyperemesis gravidarum (HG) is a pregnancy condition characterised by severe nausea and vomiting during early pregnancy. The experience of HG is for many women a traumatic event. Few studies have investigated a possible association between HG and birth-related posttraumatic stress. Read More

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September 2018
1 Read

Characteristics and Outcomes of Ptyalism Gravidarum.

Isr Med Assoc J 2018 Sep;20(9):573-575

Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel.

Background: Ptyalism gravidarum (PG) is a condition of hypersalivation that affects pregnant women early in gestation. Symptoms include massive saliva volumes (up to 2 liters per day), swollen salivary glands, sleep deprivation, significant emotional distress, and social difficulties.

Objectives: To examine maternal and fetal characteristics and pregnancy outcomes of patients with PG. Read More

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September 2018
12 Reads

Interventions for treating hyperemesis gravidarum: a network meta-analysis of randomized clinical trials.

J Matern Fetal Neonatal Med 2018 Sep 25:1-7. Epub 2018 Sep 25.

b School of Oral Health, College of Medicine, Nursing and Health Sciences , Fiji National University , Suva , Fiji.

Background: Several interventions were explored in clinical trials for treating hyperemesis gravidarum (HG). The present study is a network meta-analysis of such interventions.

Methods: Electronic databases were searched for appropriate randomized clinical trials comparing interventions for treatment of patients with HG. Read More

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September 2018
10 Reads

Cyclic Vomiting Syndrome in Children and Adults: What Is New in 2018?

Curr Gastroenterol Rep 2018 Aug 29;20(10):46. Epub 2018 Aug 29.

Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI, USA.

Purpose Of Review: Cyclic vomiting syndrome (CVS) is a disabling functional gastrointestinal disorder characterized by severe vomiting episodes that alternate with symptom-free periods. The purpose of this review is to summarize current knowledge and highlight most recent data on prevalence, diagnosis, management, and impact of CVS in children and adults.

Recent Findings: Originally thought to be a pediatric disorder, the past decade has witnessed a considerable increase in CVS diagnosed in adults. Read More

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August 2018
6 Reads

Cannabinoid Hyperemesis Syndrome Masquerading as Uremia: An Educational Case Report.

Can J Kidney Health Dis 2018 24;5:2054358118791146. Epub 2018 Aug 24.

Kidney Health, Saskatchewan Health Authority, Saskatoon, Canada.

Rationale: With marijuana legalization, clinicians need to be aware of Cannabinoid Hyperemesis Syndrome (CHS), which may masquerade as other disease states such as uremia.

Presenting Concerns Of The Patient: A 37-year-old man with bipolar affective disease treated with lithium had progressive renal insufficiency presumably on the basis of interstitial fibrosis. He developed persistent and severe nausea and vomiting which was assumed to be on the basis of uremia. Read More

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August 2018
6 Reads

Profound Hypokalaemia Resulting in Maternal Cardiac Arrest: A Catastrophic Complication of Hyperemesis Gravidarum?

Case Rep Obstet Gynecol 2018 29;2018:4687587. Epub 2018 Jul 29.

Obstetrics and Gynaecology Staff Specialist, Gold Coast University Hospital, Australia.

We present a case of a 39-year-old G8P6 Pacific Islander woman who at 15+5 weeks' gestation had an out-of-hospital cardiac arrest secondary to profound hypokalaemia which was associated with severe hyperemesis gravidarum (HG). Her clinical course after arrest was complicated by a second 5-minute cardiac arrest in the Intensive Care Unit (ICU) (pre-arrest potassium 1.8), anuric renal failure requiring dialysis, ischaemic hepatitis, and encephalopathy and unfortunately fetal demise and a spontaneous miscarriage on day 2 of admission. Read More

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July 2018
7 Reads

Recurrence patterns of hyperemesis gravidarum.

Am J Obstet Gynecol 2018 Nov 16;219(5):469.e1-469.e10. Epub 2018 Aug 16.

Department of Obstetrics and Gynecology, Turku University Hospital and University of Turku, Turku, Finland.

Background: Hyperemesis gravidarum, excessive vomiting in pregnancy, affects approximately 0.3-3.0% of all pregnancies, but the risk is considerably higher in pregnancies following a hyperemetic pregnancy. Read More

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November 2018
12 Reads

Lung adenocarcinoma presenting with an orbital metastasis.

Respir Med Case Rep 2018 7;25:116-118. Epub 2018 Aug 7.

Department of Pathology Anatomy, Faculty of Medicine Muhammadiyah University of Sumatera Utara, Jl. Gedung Arca No. 53, Medan, 20217, Sumatera Utara, Indonesia.

Orbital metastasis of lung adenocarcinoma is very rare. The incidence is only found to be approximately 7%-12% of lung cancer cases. The lack of knowledge about orbital metastasis results in misdiagnosis between malignant or benign lesion. Read More

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Optic Discs Swelling Procrastinates Wernicke's Encephalopathy Associated with Hyperemesis Gravidarum: A Case Report and Review of Literature.

Cureus 2018 Jun 12;10(6):e2793. Epub 2018 Jun 12.

Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, MYS.

Wernicke's encephalopathy following severe hyperemesis gravidarum is an uncommon clinical entity. We describe a rare manifestation of optic discs swelling in a pregnant woman that has caused a diagnostic dilemma. With high index of suspicion of clinical manifestations and radiological evidences, a clinical diagnosis of Wernicke's encephalopathy was made. Read More

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June 2018
5 Reads

The Sustained Value of an Early Pregnancy Assessment Clinic in the Management of Early Pregnancy Complications: A 10-Year Retrospective Study.

J Obstet Gynaecol Can 2018 Aug;40(8):1017-1023

Maternal, Newborn and Teen Program, Department of Obstetrics and Gynaecology, North York General Hospital, Toronto, ON; Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Toronto, Toronto, ON. Electronic address:

Objective: This study sought to evaluate the sustained value of an early pregnancy assessment clinic (EPAC) in the management of early pregnancy complications and its effect on the incidence emergency room (ER) visits.

Methods: A 10-year retrospective study (January 2006 to December 2015) was conducted. The number of patients assessed, sources and reasons for referral, and treatments provided were reviewed. Read More

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August 2018
2 Reads

[Nausea and vomiting in pregnancy].

Rev Med Suisse 2018 Aug;14(614):1397-1400

Service des urgences, CHUV, 1011 Lausanne.

Nausea and vomiting in early pregnancy is a common condition at risk to be minimized by women or care providers. If not treated in the early stages, it can evolve to a severe condition with a morbidity risk for the mother and/or the fetus, and expose to public health consequences. Severe forms of nausea and vomiting and hyperemesis gravidarum are a clinical diagnosis with nonspecific manifestations in addition to biologic and metabolic consequences for mother and/or child. Read More

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August 2018
3 Reads

[Abnormal liver tests during pregnancy - emergency department decision making].

Rev Med Suisse 2018 Aug;14(614):1382-1385

Service de médecine interne générale, Département de médecine interne, réhabilitation et gériatrie, HUG, 1211 Genève 14.

Abnormal liver biochemical and function tests is common problem among patients in emergency department and can result from many different pathologies. In pregnant women, causes are sometime life-threating for the mother and the fetus. The role of emergency physician is : 1) to differentiate between serious (HELPPS syndrome, pre-eclampsia and eclampsia, acute fatty liver of pregnancy) and minor (intrahepatic cholestasis, hyperemesis gravidarum) pregnancy related liver disease and 2) to recognize non-pregnancy related liver disease. Read More

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August 2018
3 Reads

[A Lot of Hot Steam: the Cannabinoid Hyperemesis Syndrome].

Dtsch Med Wochenschr 2018 Aug 7;143(16):1182-1185. Epub 2018 Aug 7.

Sana Klinikum Lichtenberg, Klinik für Innere Medizin I Schwerpunkt: Gastroenterologie.

History:  The 43-year-old patient was admitted because of vomiting and abdominal pain. He had a history of depression and multiple discus prolapses. He reported the consumption of three beers per day. Read More

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August 2018
3 Reads

Vitamin D deficiency associated with dilated cardiomyopathy in early infancy caused by maternal cholestasis.

Clin Pediatr Endocrinol 2018 31;27(3):187-192. Epub 2018 Jul 31.

Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan.

Breast feeding is known to be a major cause of vitamin D deficiency in infants because the content of vitamin D in breast milk is significantly lower than that in formula. We report a case of a 1-mo-old boy who developed hypocalcemic seizures and dilated cardiomyopathy caused by vitamin D deficiency despite being fed a sufficient amount of regular formula. The cause of vitamin D deficiency in this case was maternal vitamin deficiency due to severe hyperemesis and insufficient sunlight exposure, induced mainly by the malabsorption of fat-soluble vitamins caused by maternal cholestasis. Read More

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July 2018
1 Read

Late neurological deficit after attempted PICC insertion in the arm.

J Vasc Access 2018 Aug 3:1129729818790404. Epub 2018 Aug 3.

5 Vascular Surgeon, Hospital Municipal Vila Santa Catarina / Hospital Israelita Albert Einstein, São Paulo, Brazil.

Introduction: Insertion of central catheters in peripheral vessels is a common procedure performed for a variety of indications, including parenteral nutrition. Hyperemesis gravidarum may require parenteral nutrition in exceptional situations. Although globally safe, insertion of peripherally inserted central catheters (PICCs) can lead to complications. Read More

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August 2018
7 Reads

Points & Pearls: Cannabinoids: emerging evidence in use and abuse

Emerg Med Pract 2018 Aug 1;20(Suppl 8):1-2. Epub 2018 Aug 1.

EMS Fellow, University of Pittsburgh Medical Center, Pittsburgh, PA

Despite current legal and medical controversies surrounding cannabinoids, it is a fact that emergency departments are seeing an increasing number of patients presenting with symptoms associated with the use of these drugs. This review outlines the pathophysiology of cannabinoids, the potential clinical findings associated with their use, and the current evidence for best-practice management of patients who present to the emergency department with signs of acute intoxication and chronic use. Differences between natural and synthetic cannabinoids are discussed, along with the latest evidence for diagnosing and managing patients presenting with the intractable vomiting of cannabinoid hyperemesis syndrome. Read More

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August 2018
1 Read

Cannabinoids: emerging evidence in use and abuse.

Authors:
Molly V Williams

Emerg Med Pract 2018 Aug 1;20(8):1-20. Epub 2018 Aug 1.

Attending Physician, Residency Program Director, Department of Emergency Medicine, The Brooklyn Hospital Center, Brooklyn, NY.

Despite current legal and medical controversies surrounding cannabinoids, it is a fact that emergency departments are seeing an increasing number of patients presenting with symptoms associated with the use of these drugs. This review outlines the pathophysiology of cannabinoids, the potential clinical findings associated with their use, and the current evidence for best-practice management of patients who present to the emergency department with signs of acute intoxication and chronic use. Differences between natural and synthetic cannabinoids are discussed, along with the latest evidence for diagnosing and managing patients presenting with the intractable vomiting of cannabinoid hyperemesis syndrome. Read More

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August 2018
1 Read

Wernicke's Encephalopathy as a Rare Complication of Hyperemesis Gravidarum: A Case Report and Review of Literature.

Cureus 2018 May 9;10(5):e2597. Epub 2018 May 9.

Department of Neurology, University of Missouri, Columbia, USA.

Wernicke's encephalopathy (WE) is a rare neurological syndrome that presents in the setting of thiamine deficiency. Though alcoholism is the most common cause of this condition, a few other etiologies include malnutrition from other causes, hemodialysis, and hyperemesis gravidarum. In this case report, we aim to report a case of a young woman who developed WE in the setting of hyperemesis gravidarum (HG) that improved with thiamine replacement. Read More

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May 2018
2 Reads

Risk factors of new onset anxiety and anxiety exacerbation in the perinatal period: A systematic review and meta-analysis.

J Affect Disord 2018 10 18;238:626-635. Epub 2018 Jun 18.

Neuroscience Graduate Program, McMaster University, Ontario, Canada; Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, Ontario, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Ontario, Canada. Electronic address:

Background: Even though more than 20% of women meet diagnostic criteria for an anxiety disorder during the perinatal period, very little is known about the predictors of these problems. As a result, we systematically reviewed the literature on risk factors for new onset anxiety and maternal anxiety exacerbation in the perinatal period.

Methods: PubMed, MEDLINE, PsycINFO, CINAHL, Ovid, ProQuest Portal, and Web of Science were searched for studies assessing risk factors for the development of new onset anxiety or anxiety worsening in women during pregnancy and the postpartum period. Read More

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October 2018
9 Reads

Effect of severe hyperemesis gravidarum on maternal vascular endothelial health: evaluation of soluble adhesion molecules.

J Matern Fetal Neonatal Med 2018 Aug 13:1-5. Epub 2018 Aug 13.

d Department of Obstetrics and Gynecology , Erciyes University Medicine Faculity , Kayseri , Turkey.

Purpose: This study aimed to clarify the effect of severe hyperemesis gravidarum (sHG) on maternal vascular endothelial health with evaluation of soluble adhesion molecules.

Method: The study population consisted of two groups of pregnant participants between 18 and 35 years of age who were between 5 and 13 weeks of gestation: sHG group and a healthy control group. A group of 26 participants whose pregnancies were complicated by sHG was compared with 26 healthy participants regarding serum levels of the soluble adhesion molecules such as E-selectin, soluble intracellular cell adhesion molecule 1 (sICAM-1), and soluble vascular cell adhesion molecule one (sVCAM-1), as well as other biochemical markers. Read More

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August 2018
1 Read

Cannabinoids for Treatment of MS Symptoms: State of the Evidence.

Curr Neurol Neurosci Rep 2018 Jun 19;18(8):50. Epub 2018 Jun 19.

Oregon Health & Science University, 3181 SW Sam Jackson Park Rd. L226, Portland, OR, 97239, USA.

Purpose Of Review: Cannabis and cannabinoids have been used medically and recreationally for thousands of years and recently there has been a growing body of research in this area. With increased access now that medical marijuana is available in many jurisdictions, patients and providers want to know more about the evidence for benefits and risks of cannabinoid use. This paper provides an overview of the available cannabinoid-based formulations, a summary of the highest quality evidence for the use of cannabinoids for treating spasticity and pain associated with multiple sclerosis (MS), and a discussion of possible dosing regimens based on information from these studies. Read More

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June 2018
36 Reads

Hyperemesis gravidarum-Is it a cause of abnormal fetal brain development?

Reprod Toxicol 2018 Aug 18;79:84-88. Epub 2018 Jun 18.

Motherisk Israel, Clinical Pharmacology and Toxicology Unit, Assaf Harofeh Medical Center, Zerifin; Sackler Faculty of Medicine, Tel Aviv University, Israel; The Hebrew University, Israel.

Hyperemesis gravidarum (HG) is characterized by severe gestational nausea and vomiting, leading to dehydration, electrolyte imbalance and nutritional deficits. HG adversely affects the health and wellbeing of the woman. However, the detrimental impact of HG on fetal brain development has not been addressed. Read More

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August 2018
2 Reads

The Use of Cannabinoids in Colitis: Hyperemesis Syndrome.

Inflamm Bowel Dis 2018 Jun 15. Epub 2018 Jun 15.

Clinical Professor of Medicine, New York University Medical Center, New York, NY, USA.

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June 2018
3 Reads

Cardiovascular risk profile at the age of 40-45 in women with previous hyperemesis gravidarum or hypertensive disorders in pregnancy: A population-based study.

Pregnancy Hypertens 2018 Apr 11;12:129-135. Epub 2018 Apr 11.

Division for Mental and Physical Health, National Institute of Public Health, 0403 Oslo, Norway; Faculty of Medicine, University of Oslo, 0316 Oslo, Norway.

Objective: To assess midlife cardiovascular risk profiles in women with a history of hyperemesis or hypertensive disorders in pregnancy compared to women with none of the studied pregnancy complications.

Study Design: Population-based study. Cardiovascular risk factors at the age of 40-45 among women with previous singleton births only were studied through linkage of the Norwegian Birth Registry and a Norwegian screening program (the Age 40 Program). Read More

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April 2018
1 Read

Epidemiology, Clinical Characteristics, and Associations for Rome IV Functional Nausea and Vomiting Disorders in Adults.

Clin Gastroenterol Hepatol 2018 May 29. Epub 2018 May 29.

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background & Aims: Functional nausea and vomiting disorders (FNVDs) are classified as chronic nausea and vomiting syndrome (CNVS) or cyclic vomiting syndrome (CVS)-CVS includes cannabinoid hyperemesis syndrome. We investigated the population prevalence of FNVDs, their characteristics, and associated factors.

Methods: In the year 2015, an Internet cross-sectional health survey was completed by 5931 adults in the general populations of 3 English-speaking countries; 2100 participants were in the United States, Canada, or the United Kingdom. Read More

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New Insight Into Hyperemesis Gravidarum and a Potential Role for GDF15.

Endocrinology 2018 Jul;159(7):2698-2700

Department of Molecular Genetics, Biochemistry and Microbiology, College of Medicine, University of Cincinnati, Cincinnati, Ohio.

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July 2018
3 Reads

Cannabinoid Hyperemesis Syndrome: Reports of Fatal Cases.

J Forensic Sci 2018 May 16. Epub 2018 May 16.

Department of Pathology and Laboratory Medicine, Foothills Medical Center, Cumming School of Medicine, University of Calgary, McCaig Tower 7542, 1403 29 Street NW, Calgary, AB, T2N 2T9, Canada.

Cannabinoid hyperemesis syndrome (CHS) is one of the more clinically challenging effects of cannabis consumption. It is characterized by cyclic attacks of nausea and vomiting in chronic cannabinoid users and learned behavior of compulsive hot bathing. The deaths of a 27-year-old female, a 27-year-old male, and a 31-year-old male with a history of CHS are reported. Read More

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May 2018
60 Reads
1.310 Impact Factor

Ondansetron in Pregnancy and the Risk of Congenital Malformations: A Systematic Review.

J Obstet Gynaecol Can 2018 Jul 10;40(7):910-918. Epub 2018 May 10.

Department of Obstetrics and Gynecology, University of Alberta, Lois Hole Hospital for Women, Edmonton, AB; Women and Children's Health Research Institute, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB. Electronic address:

Objective: Ondansetron, not approved for use in pregnancy, is increasingly being prescribed for nausea and vomiting in pregnancy and hyperemesis gravidarum. A number of recent lawsuits have highlighted the possibility that ondansetron may cause congenital malformations. The aim of this study was to systematically review epidemiological evidence on the potential association of prenatal exposure to ondansetron and congenital malformations. Read More

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July 2018
3 Reads

Serum betatrophin/angiopoietin-like protein 8 (ANGPTL8) levels in pregnancies affected by hyperemesis gravidarum.

Eur J Obstet Gynecol Reprod Biol 2018 Jun 24;225:221-227. Epub 2018 Apr 24.

Department of Obstetrics and Gynecology, Etlik Zubeyde Hanim Maternity and Women's Health Teaching and Research Hospital, University of Health Sciences, Ankara, Turkey.

Objective: The association between serum betatrophin levels and hyperemesis gravidarum (HEG) remains unknown. The aim of this study was to determine and understand the alterations in serum betatrophin levels in pregnancies complicated by HEG compared with unaffected normal pregnancies.

Study Design: A cohort study was carried out to evaluate serum betatrophin levels in patients with HEG. Read More

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June 2018
18 Reads

Cannabinoid hyperemesis syndrome.

Rev Esp Enferm Dig 2018 May;110(5):334-335

Aparato Digestivo, Complexo Hospitalario Universitario A Coruña.

We report the case of a 30-year-old female with a history of cannabis use from 16 years of age. The patient presented to the Gastroenterology Clinic due to cyclical epigastric pain associated with postprandial stomach heaviness, nausea and vomiting. She was admitted due to a worsening of her condition, which prevented her from leading a normal life. Read More

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