J Clin Lipidol 2022 May 20. Epub 2022 May 20.
School of Medicine, Faculty of Medicine and Health Sciences, The University of Western Australia, Perth, Australia (Drs Page, Ellis, Chan, Pang, Hooper, Bell, Burnett, and Watts); Lipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, Perth, Australia (Drs Bell, Burnett, and Watts). Electronic address:
Background: Increased risk of coronary artery disease (CAD) in familial hypercholesterolaemia (FH) is modified by factors beyond defects in the low-density lipoprotein receptor pathway. The rs1250229-T single nucleotide polymorphism (SNP) in the FN1 gene is associated with CAD in genome-wide association studies and is in linkage disequilibrium with another SNP (rs1250259-T) in FN1 that is associated with decrease fibronectin secretion.
Objective: We investigated whether rs1250229-T was also associated with prevalent CAD in patients with genetically confirmed FH. Read More