20,329 results match your criteria Hypercalcemia


Appearances of soft tissue calcification on Tc99m MDP bone scan.

J Pak Med Assoc 2019 Apr;69(4):600

Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.

Metastatic calcification relates to abnormal calcification resulting from hypercalcaemia in otherwise normal tissues. Hypercalcaemia can occur secondary to chronic renal failure, hyperparathyroidism, hypervitaminosis D, and metastatic neoplasms. Specific symptoms are often lacking, but calcification may be a marker of disease severity and its chronicity. Read More

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Characteristics of parathyroid hormone-1 receptor agonists and antagonists.

Future Med Chem 2019 Apr 18. Epub 2019 Apr 18.

Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.

Parathyroid hormone-1 receptor (PTH1R) is a member of B G protein-coupled receptors. The agonistic activation of the PTH1R results in the production and secretion of osteoclast-stimulating cytokines while antagonists may be used to treat bone metastases, hypercalcemia, cachexia and hyperparathyroidism. We built pharmacophore models and investigated the characteristics of PTH1R agonists and antagonists. Read More

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http://dx.doi.org/10.4155/fmc-2018-0508DOI Listing

Primary hyperparathyroidism.

Authors:
Ao Wang Lei Yuan

Clin Case Rep 2019 Apr 5;7(4):849-850. Epub 2019 Mar 5.

Department of Endocrinology, the Second Affiliated Hospital Chongqing Medical University Chongqing China.

We report a case of hyperparathyroidism with hypercalcemia caused by a giant parathyroid adenoma. We use a technetium sestamibi scan to locate parathyroid mass. Bone emission computed tomography revealed the classic signs of metabolic osteopathy. Read More

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http://dx.doi.org/10.1002/ccr3.2035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452475PMC

Proton-pump Inhibitor-induced Severe Hypomagnesemia and Hypocalcemia are Clinically Masked by Thiazide Diuretic.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan.

Hypomagnesemia, a side effect of proton-pump inhibitors (PPIs), can be asymptomatic. The presence of hypocalcemia or hypokalemia is indicative of hypomagnesemia; however, the concomitant use of PPIs and thiazide may mask hypocalcemia. A 79-year-old woman with a history of chronic heart failure and chronic kidney disease developed symptomatic hypocalcemia and hypomagnesemia. Read More

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http://dx.doi.org/10.2169/internalmedicine.2608-18DOI Listing
April 2019
1 Read

Cinacalcet corrects biased allosteric modulation of CaSR by AHH autoantibody.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Department of Endocrinology and Nephrology, The University of Tokyo School of Medicine, Tokyo, Japan.

Biased agonism is a paradigm that may explain the selective activation of a signaling pathway via a GPCR that activates multiple signals. The autoantibody-induced inactivation of the calcium-sensing receptor (CaSR) causes acquired hypocalciuric hypercalcemia (AHH). Here, we describe an instructive case of AHH in which severe hypercalcemia was accompanied by an increased CaSR antibody titer. Read More

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https://insight.jci.org/articles/view/126449
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http://dx.doi.org/10.1172/jci.insight.126449DOI Listing
April 2019
1 Read

Clinical Features of Multiple Endocrine Neoplasia Type 4 - Novel pathogenic variant and review of published cases.

J Clin Endocrinol Metab 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical Research, Faculty of Health, University of Southern Denmark (SDU).

Context: The clinical phenotype of multiple endocrine neoplasia type 4 (MEN4) is undefined due to a limited number of published cases. Knowledge on disease manifestation in MEN4 is essential for developing prevention programs and treatment.

Objective: To expand current knowledge of the MEN4 phenotype including assessment of penetrance. Read More

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http://dx.doi.org/10.1210/jc.2019-00082DOI Listing
April 2019
1 Read

Effects of denosumab on hypercalcemia and bone mineral density loss in kidney transplant recipients
.

Clin Nephrol 2019 Apr 16. Epub 2019 Apr 16.

Background: Hypercalcemia and bone mineral density (BMD) loss are serious problems associated with post-transplant chronic kidney disease-mineral and bone disorder. The present study aimed to clarify the effects of denosumab on hypercalcemia complicated with BMD loss in kidney transplant recipients.

Materials And Methods: Among 100 consecutive adult kidney transplant recipients, 16 patients with serum corrected Ca (cCa) levels ≥ 11. Read More

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http://dx.doi.org/10.5414/CN109723DOI Listing
April 2019
2 Reads

Hypercalcaemia: A portent of sarcoidosis in cystic fibrosis.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e533-e536. Epub 2019 Mar 28.

Department of Medicine, Sultan Qaboos University Hospital, Muscat, Oman.

The coexistence of cystic fibrosis (CF) and sarcoidosis is rare. We report a 22-year-old male cystic fibrosis patient who presented multiple times to the Sultan Qaboos University Hospital, Muscat, Oman, in 2013. He was diagnosed with non-parathyroid-related hypercalcaemia and anterior uveitis, while computed tomography revealed mediastinal and abdominal lymphadenopathy and mild hepatosplenomegaly. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443288PMC
November 2018
1 Read

Teaching Images in Headache: Concurrent Hypercalcemia-Induced Reversible Cerebral Vasoconstriction Syndrome and Posterior Reversible Encephalopathy Syndrome.

Headache 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Neurosciences & Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

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http://dx.doi.org/10.1111/head.13528DOI Listing
April 2019
1 Read

Diagnosis and treatment of confirmed and suspected primary hyperparathyroidism in equids: 17 cases (1999-2016).

Equine Vet J 2019 Apr 13. Epub 2019 Apr 13.

Baker Institute for Animal Health, Cornell University College of Veterinary Medicine, Ithaca, New York, 14853, USA.

Background: Primary hyperparathyroidism is uncommon in equids.

Objectives: To describe the diagnostic findings and efficacy of treatment in equids with primary hyperparathyroidism.

Study Design: Retrospective case series describing sixteen horses and one mule. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/evj.13120
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http://dx.doi.org/10.1111/evj.13120DOI Listing
April 2019
7 Reads

Deficiency in the secreted protein Semaphorin3d causes abnormal parathyroid development in mice.

J Biol Chem 2019 Apr 12. Epub 2019 Apr 12.

Cardiovascular and Metabolic Disorders Program, Duke NUS Medical School, Singapore.

Primary hyperparathyroidism (PHPT) is a common endocrinopathy characterized by hypercalcemia and elevated levels of parathyroid hormone. The primary cause for PHPT is a benign overgrowth of parathyroid tissue causing excessive secretion of parathyroid hormone. However, the molecular etiology of PHPT is incompletely defined. Read More

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http://dx.doi.org/10.1074/jbc.RA118.007063DOI Listing
April 2019
1 Read

Biological secondary contributors to osteoporosis in fractured patients, is an early systematic assay relevant?

Joint Bone Spine 2019 Apr 9. Epub 2019 Apr 9.

Rheumatology Department, Cochin Hospital, 75014 Paris, France; INSERM U1153, 75014 Paris France. Electronic address:

Objective: To evaluate the prevalence of biological abnormalities leading to secondary osteoporosis in recently fractured patients.

Methods: Adults older than 50, hospitalized for a nonvertebral fracture from July 2015 to October 2016, were assessed for bone fragility contributors in the Orthopedics Department. Bone mineral density (BMD) measurements and Vertebral Fracture assessment (VFA) were performed within 3 months. Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.03.009DOI Listing
April 2019
1 Read

Response to Letter to the Editor: Gestational Gigantomastia Complicated by PTHrP-Mediated Hypercalcemia.

J Clin Endocrinol Metab 2019 Apr 12. Epub 2019 Apr 12.

Assistant Professor, Department of Endocrinology, Diabetes and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
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http://dx.doi.org/10.1210/jc.2019-00820DOI Listing
April 2019
7 Reads

Bradycardia secondary to primary hyperparathyroidism.

J Int Med Res 2019 Apr 10:300060519841156. Epub 2019 Apr 10.

1 Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.

Clinical doctors rarely associate hyperparathyroidism with significant bradyarrhythmia. We report a rare case of a patient initially misdiagnosed with primary sick sinus syndrome, which was eventually shown to be secondary to primary hyperparathyroidism. Read More

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http://dx.doi.org/10.1177/0300060519841156DOI Listing
April 2019
1 Read

The Key Role of Phosphate on Vascular Calcification.

Toxins (Basel) 2019 Apr 9;11(4). Epub 2019 Apr 9.

Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, S. Orsola Hospital, University of Bologna, 40138 Bologna, Italy.

Vascular calcification (VC) is common in dialysis and non-dialysis chronic kidney disease (CKD) patients, even in the early stage of the disease. For this reason, it can be considered a CKD hallmark. VC contributes to cardiovascular disease (CVD) and increased mortality among CKD patients, although it has not been proven. Read More

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http://dx.doi.org/10.3390/toxins11040213DOI Listing
April 2019
1 Read

Morbidity and mortality of bone metastases in advanced adrenocortical carcinoma: a multicenter retrospective study.

Eur J Endocrinol 2019 May;180(5):311-320

Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, Orbassano, University of Turin, Turin, Italy.

Introduction Adrenocortical carcinoma (ACC) is a rare cancer that commonly spreads to the liver, lungs and lymph nodes. Bone metastases are infrequent. Objective The aim of this report was to describe the clinical characteristics, survival perspective, prognostic factors and frequency of adverse skeletal-related events (SREs) in patients with ACC who developed bone metastasis. Read More

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http://dx.doi.org/10.1530/EJE-19-0026DOI Listing
May 2019
4 Reads

Pseudovascular squamous cell carcinoma with eosinophil-rich stroma.

Authors:
Yamil Lopez

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):87-89

Loma Linda University Medical Center, Loma Linda, CA, USA.

Pseudovascular squamous cell carcinoma (SCC) is a rare variant of SCC characterized by acantholysis and necrosis with preservation of vascular-like cords and spaces mimicking glands or vascular differentiation. Only three cases of this variant in the oral cavity have been reported in the literature. However, none of these cases were eosinophil-rich, which is considered to be a good prognostic indicator for conventional SCC. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_276_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421930PMC
February 2019
1 Read

Dysregulation of Calcium Metabolism in Type 1 Myotonic Dystrophy.

Intern Med J 2019 Apr 9. Epub 2019 Apr 9.

Department of Internal Medicine, Logan Hospital, Brisbane, QLD, Australia.

Background: Type 1 myotonic dystrophy (DM1) patients have a higher incidence of hypercalcemia compared to the general population. The nature and effects of dysregulated calcium metabolism underpinning this phenomenon have not been fully characterised.

Aims: To determine the characteristics of dysregulated calcium metabolism in DM1 patients and its association with bone mineral density. Read More

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http://dx.doi.org/10.1111/imj.14307DOI Listing
April 2019
2 Reads

Ovarian Small Cell Carcinoma of Hypercalcemic Type in an Adolescent Girl.

J Obstet Gynaecol India 2019 Apr 2;69(Suppl 1):60-62. Epub 2018 Feb 2.

1Department of Radiotherapy and Oncology, Government Medical College and Hospital, Chandigarh, India.

Objective: Small cell carcinoma of ovary, hypercalcemic type is a rare malignancy with a dismal prognosis. The diagnosis is often confused with many other tumors.

Case Report: We describe a rare case of ovarian small cell carcinoma of hypercalcemic type in an adolescent. Read More

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http://dx.doi.org/10.1007/s13224-018-1091-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431709PMC
April 2019
2 Reads

Rhinovirus infections in infants suggest that early detection can prevent unnecessary treatment.

J Clin Virol 2019 Mar 21;115:11-17. Epub 2019 Mar 21.

Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical Center, Ramat-Gan, 52621, Israel; Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:

Background: Human rhinoviruses (hRV) are small, RNA viruses of the Picornaviridae family, which are divided into three subtypes (A, B, C). hRVs are among the most common causes for acute respiratory illnesses (ARI) involving both the upper and lower respiratory tract.

Objectives: This study aimed to assess the magnitude and characteristics of hRV infections in hospitalized children, aged less than 5 years, hospitalized in Israel during 2011-2012. Read More

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http://dx.doi.org/10.1016/j.jcv.2019.03.012DOI Listing
March 2019
3.016 Impact Factor

Paraneoplastic Lambert-Eaton syndrome in a patient with disseminated metastatic cancer.

Cir Cir 2019 ;86(1):72-76

Rehabilitation Medicine, Faculty of Medicine, Universidad de Guanajuato. León, Gto., Mexico.

Background: Neurological paraneoplastic syndromes are rare, occur in 0.01% of all cancer patients; like part of them, the Lambert-Eaton syndrome is an autoimmune presynaptic disorder of neuromuscular transmission characterized by muscle weakness and neurovegetative dysfunction, and often associated with small cell lung cancer.

Case Report: A 72 years old female with a family history of lung cancer and leukemia, with 7 months of dry cough and 3 months with waist and pelvic muscle weakness, oropharyngeal dysphagia, dry mouth, chronic constipation and weight loss of 10 kg. Read More

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http://dx.doi.org/10.24875/CIRUE.M18000011DOI Listing
January 2019
5 Reads

Parkinsonism as presenting symptom of primary hyperparathyroidism: Improvement after surgery.

Cir Cir 2019 ;86(1):96-98

Department of General and Digestive System Surgery, Hospital General Universitario Reina Sofía, Murcia, Spain.

Introduction: Hypercalcemia can cause different neurological disorders, depending on the calcium level. We report an exceptional case of primary hyperparathyroidism presenting as neurological alteration and it has favourable outcome after parathyroidectomy.

Case Report: A 74-year-old woman presented with progressive cognitive deterioration and impaired motor function. Read More

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http://dx.doi.org/10.24875/CIRUE.M18000015DOI Listing
January 2019
1 Read

Infantile hypercalcemia with novel compound heterozygous mutation in SLC34A1 encoding renal sodium-phosphate cotransporter 2a: a case report.

Ann Pediatr Endocrinol Metab 2019 Mar 31;24(1):64-67. Epub 2019 Mar 31.

Department of Pediatrics, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

Idiopathic infantile hypercalcemia is characterized by hypercalcemia, dehydration, vomiting, and failure to thrive, and it is due to mutations in 24-hydroxylase (CYP24A1). Recently, mutations in sodium-phosphate cotransporter (SLC34A1) expressed in the kidney were discovered as an additional cause of idiopathic infantile hypercalcemia. This report describes a female infant admitted for evaluation of nephrocalcinosis. Read More

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http://dx.doi.org/10.6065/apem.2019.24.1.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449619PMC
March 2019
2 Reads

An anatomic aberration and a surgical challenge: Mediastinal parathyroid adenoma anterior the pericardium. A case report.

Int J Surg Case Rep 2019 Mar 21;57:106-109. Epub 2019 Mar 21.

Anatomy and Histology Laboratory, School of Nursing, University of Athens, Greece; University Department of Surgery, General and Oncologic Hospital of Kifissia "Agii Anargiri", Athens, Greece.

Introduction: Ectopic parathyroid glands occur in 6-16% of cases of PHPT and they constitute a potential cause of failed primary surgical therapy. In particular, aberrant adenomas located deeper in the mediastinum, as in the presented case, remain a severe challenge for the surgeons.

Presentation Of Case: A 54-year-old Caucasian female proceeded to our institution with signs and symptoms of PHPT. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444067PMC
March 2019
4 Reads

Doughnut Shaped Parathyroid Adenoma

Mol Imaging Radionucl Ther 2019 Mar;28(1):41-43

University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Pathology, Ankara, Turkey

A 52-year-old woman presented with a complaint of neck swelling. The patient showed signs of hyperparathyroidism: hypercalcemia, and hypophosphatemia. Tc-99m MIBI dual-phase parathyroid scintigraphy and SPECT revealed increased activity in a regular-bordered, “doughnut”-shaped mass on the left side of the thyroid gland with a central hypoactive area. Read More

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http://dx.doi.org/10.4274/mirt.galenos.2018.06977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455100PMC
March 2019
8 Reads

Obesity attenuates serum 25-hydroxyvitamin D response to cholecalciferol therapy in critically ill patients.

Nutrition 2019 Jan 30;63-64:120-125. Epub 2019 Jan 30.

Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Objectives: The presence of obesity may confound cholecalciferol dosing in vitamin D-deficient patients owing to potentially decreased bioavailability. The aim of this retrospective study was to evaluate cholecalciferol therapy in vitamin D-deficient, critically ill trauma patients with and without obesity.

Methods: Adult patients with severe traumatic injuries who had a serum 25-hydroxyvitamin D (25-OH vit D) <50nmol/L were prescribed 10 000 IU of liquid cholecalciferol daily. Read More

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http://dx.doi.org/10.1016/j.nut.2019.01.018DOI Listing
January 2019
2 Reads

Dual Tracer 99mTc-Pertechnetate/99mTc-MIBI Dual-Time-Point SPECT/CT Parathyroid Gland Assessment Regarding to Parathyroid Gland Size and Biochemical Parameters - Two Years Single Imaging Centre Experience.

Acta Medica (Hradec Kralove) 2019 ;62(1):1-5

Nuclear Medicine Department, University Hospital Hradec Králové, Czech Republic.

Introduction: Preoperative parathyroid imaging is inevitable part of focused parathyroid surgery. The aim of our study was assessment of parathyroid scintigraphy diagnostic accuracy regarding to size and metabolic parameters of hyperfunctioning parathyroid tissue.

Material And Methods: Parathyroid scintigraphy for suspected primary hyperparathyroidism was performed in 95 patients during years 2015 and 2016. Read More

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https://actamedica.lfhk.cuni.cz/62/1/0001/
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http://dx.doi.org/10.14712/18059694.2019.38DOI Listing
January 2019
6 Reads

[A case of muscle sarcoidosis with hypercalcemia, lower limb muscle strength and without bilateral hilar lymphadenopathy].

Rinsho Shinkeigaku 2019 Mar 30. Epub 2019 Mar 30.

Department of Internal Medicine, Division of Neurology, Hyogo College of Medicine.

A 73-year-old man was hospitalized with complaints of general malaise, limb muscle weakness and weight loss progressing in 6 months. Ca, ACE, lysozyme, sIL-2R, vitamin 1.25 D was high in the blood test. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001256DOI Listing
March 2019
4 Reads

A mathematical model of parathyroid gland biology.

Physiol Rep 2019 Apr;7(7):e14045

Renal Research Institute, New York City, New York.

Altered parathyroid gland biology in patients with chronic kidney disease (CKD) is a major contributor to chronic kidney disease-mineral bone disorder (CKD-MBD). This disorder is associated with an increased risk of bone disorders, vascular calcification, and cardiovascular events. Parathyroid hormone (PTH) secretion is primarily regulated by the ionized calcium concentration as well as the phosphate concentration in the extracellular fluid and vitamin D. Read More

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http://dx.doi.org/10.14814/phy2.14045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440916PMC
April 2019
4 Reads

Acute Lymphoblastic Leukemia with Malignant Hypercalcemia: A Case Report.

Am J Case Rep 2019 Mar 28;20:402-405. Epub 2019 Mar 28.

Department of Pediatrics, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania.

BACKGROUND Malignant hypercalcemia is a rare finding in the pediatric population, even more rare in hematological malignancies, such as leukemia. CASE REPORT We present a case of a 6-year-old female patient who was diagnosed with acute lymphoblastic leukemia, with secondary hypercalcemia. She started chemotherapy following the IC-BFM ALL2002 protocol with simultaneous calcitonin, diuretics and aggressive hydration for hypercalcemia, and went into complete remission after the induction therapy. Read More

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http://dx.doi.org/10.12659/AJCR.914303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452782PMC
March 2019
1 Read

Anaplastic large cell lymphoma, with 1,25(OH)D-mediated hypercalcemia: A case report.

J Clin Exp Hematop 2019 ;59(1):22-28

Hypercalcemia due to malignant tumors including malignant lymphomas is relatively common. Among cancer patients with hypercalcemia, humoral hypercalcemia of malignancy is the most common and accounts for about 80% of all cases with hypercalcemia. 1,25-dihydroxyvitamin D(1,25(OH)D)-mediated hypercalcemia is relatively rare. Read More

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http://dx.doi.org/10.3960/jslrt.18033DOI Listing
April 2019
1 Read

Additional hemoperfusion is associated with improved overall survival and self-reported sleep disturbance in patients on hemodialysis.

Int J Artif Organs 2019 Mar 28:391398819837546. Epub 2019 Mar 28.

1 Division of Nephrology, Shanghai Pudong Hospital, Fudan University, Pudong Medical Center, Shanghai, China.

Introduction:: Patients with maintenance hemodialysis have experienced long-standing sleep disturbance. In this study, we attempted to explore whether long-term hemoperfusion could improve sleep and increase the overall survival in hemodialysis patients.

Methods:: A total of 158 patients, who underwent routine hemodialysis, were assessed in this study. Read More

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http://journals.sagepub.com/doi/10.1177/0391398819837546
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http://dx.doi.org/10.1177/0391398819837546DOI Listing
March 2019
3 Reads
1.448 Impact Factor

Vitamin D Supplementation as Add-on Therapy in Multiple Sclerosis-Balance between Benefit and Risk?: A Commentary on Vitamin D Supplementation in Central Nervous System Demyelinating Disease-Enough Is Enough.

Int J Mol Sci 2019 Mar 26;20(6). Epub 2019 Mar 26.

Hochwaldstrasse 2, D-97769 Bad Brückenau, Germany.

The excellent publication by Häusler and Weber [... Read More

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http://dx.doi.org/10.3390/ijms20061513DOI Listing

Serum PTH reference values in an adult Brazilian population: implications for the diagnosis of hyperparathyroidism.

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brasil.

Objective: To define serum parathyroid hormone (PTH) reference values in carefully selected subjects following the recommended pre-analytical guidelines.

Subjects And Methods: First, 676 adults who would be submitted to thyroidectomy were evaluated. Patients using interfering medications or with malabsorption syndrome, hypomagnesemia, hyper- or hypophosphatemia, hypo- or hypercalcemia, 25-hydroxyvitamin D < 30 ng/dL, estimated glomerular filtration rate < 60 mL/min/1. Read More

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http://dx.doi.org/10.20945/2359-3997000000117DOI Listing
March 2019
1 Read

Nephrocalcinosis in a patient with extrapulmonary tuberculosis - A rare entity.

J Family Med Prim Care 2019 Jan;8(1):296-298

Department of Medicine, RPGMC Tanda at Kangra, Himachal Pradesh, India.

Nephrocalcinosis is a rare condition in clinical practice where there is an increased renal deposition of calcium. Varied causes of this condition have been given in literature, and tuberculosis (TB) has been an important one. Hypercalcemia is a known complication of granulomatous diseases. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_385_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396576PMC
January 2019
1 Read

Paraneoplastic syndromes and other systemic disorders associated with neuroendocrine neoplasms.

Semin Diagn Pathol 2019 Mar 18. Epub 2019 Mar 18.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114-2696, United States. Electronic address:

Neuroendocrine paraneoplastic syndromes (PNS) consist of metabolic disorders that accompany benign and malignant neoplasms but remain unrelated to mass effects or invasion by the primary tumor or its metastases. The underlying pathogenesis responsible for PNS usual clinical presentation rely on aberrant production of protein hormones, proteins and other substances by the tumor. Prompt recognition of characteristic signs and symptoms combined with serological identification of key substances may result in early diagnosis of PNS and its underlying malignancy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07402570193002
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http://dx.doi.org/10.1053/j.semdp.2019.03.002DOI Listing
March 2019
10 Reads

Hypercalcemia and acute kidney injury induced by eldecalcitol in patients with osteoporosis: a case series of 32 patients at a single facility.

Ren Fail 2019 Nov;41(1):88-97

a Division of Kidney Center , Matsuyama Red Cross Hospital , Matsuyama , Japan.

Background: Eldecalcitol (ELD) is an active vitamin D analog that is widely used in Japan for the treatment of osteoporosis. The most common adverse drug reaction of ELD is hypercalcemia. However, few reports have focused on acute kidney injury (AKI) associated with ELD-induced hypercalcemia. Read More

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http://dx.doi.org/10.1080/0886022X.2019.1578667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442105PMC
November 2019
1 Read

Surgery for high risk locally advanced (pT3c) renal tumours: Oncological outcomes and prognostic significance of a modified International Metastatic Renal Cell Cancer Database Consortium (IMDC) score.

BJU Int 2019 Mar 25. Epub 2019 Mar 25.

Guy's & St Thomas, NHS Foundation Trust, Urology, London, United Kingdom of Great Britain and Northern Ireland.

Objectives: To evaluate contemporary oncological outcomes and long term survival in patients undergoing surgery for urological tumours involving the peridiaphragmatic inferior vena cava up to the level of the right atrium. To apply prognostic factors developed in metastatic renal cancer to patients with very high risk but apparently localized tumours, and develop a scoring system.

Patients And Methods: A retrospective cohort study of 54 patients referred between December 2007 and April 2018 to a single surgical and oncological team. Read More

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http://doi.wiley.com/10.1111/bju.14755
Publisher Site
http://dx.doi.org/10.1111/bju.14755DOI Listing
March 2019
10 Reads

Timing treatment for smoldering myeloma: is earlier better?

Expert Rev Hematol 2019 Mar 25:1-10. Epub 2019 Mar 25.

b School of Medicine , Complutense University , Madrid , Spain.

Introduction: In 2014, the International Myeloma Working Group determined that patients with ultra-high-risk smoldering multiple myeloma (SMM) should be considered for treatment as per patients with symptomatic multiple myeloma (MM), despite not having CRAB (hyperCalcemia, Renal insufficiency, Anemia, Bone disease) symptoms. Current research is elucidating whether patients with high-risk, and even intermediate-risk, SMM could benefit from early therapeutic strategies aimed at delaying progression to active MM and prolonging survival. Areas covered: The authors conducted a systematic literature search using PubMed to identify a series of patients with SMM in which prognostic and predictive factors for progression were investigated, plus the main clinical trials in SMM. Read More

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https://www.tandfonline.com/doi/full/10.1080/17474086.2019.1
Publisher Site
http://dx.doi.org/10.1080/17474086.2019.1599281DOI Listing
March 2019
6 Reads

Challenges in the treatment of parathyroid carcinoma: a case report.

Hormones (Athens) 2019 Mar 23. Epub 2019 Mar 23.

Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Hospital, University of Catania, Via Palermo 636, 95122, Catania, Italy.

Introduction: Parathyroid carcinoma (PC) is a rare neoplasm with a high rate of recurrence and an indolent course. It is frequently functional, causing nearly 1% of the cases of primary hyperparathyroidism (HPT), and in some cases, it may be complicated by brown tumors, mimicking bone metastases. Synchronous parathyroid and papillary thyroid carcinomas are rare. Read More

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http://dx.doi.org/10.1007/s42000-019-00104-wDOI Listing
March 2019
2 Reads

Reference values for 24,25-dihydroxyvitamin D and the 25-hydroxyvitamin D/24,25-dihydroxyvitamin D ratio.

Clin Chem Lab Med 2019 Mar 23. Epub 2019 Mar 23.

Amsterdam UMC, Vrije Universiteit Amsterdam, Endocrine Laboratory, Department of Clinical Chemistry, de Boelelaan 1117, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1515/cclm-2018-1096DOI Listing
March 2019
1 Read

Hypercalcemia associated with squamous cell carcinoma of renal pelvis: A case and review of the literature.

J Cancer Res Ther 2019 Mar;15(Supplement):S170-S172

Department of Medical Oncology, Akdeniz University School of Medicine, Antalya, Turkey.

Renal pelvis squamous cell carcinoma (RSCC) is a rare tumor. It starts with nonspecific symptoms and it is usually at an advanced stage with a poor prognosis at the time of diagnosis. SCC-associated hypercalcemia is a well-known paraneoplastic syndrome; however RSCC-associated hypercalcemia is a rare condition. Read More

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http://dx.doi.org/10.4103/0973-1482.187236DOI Listing
March 2019
1 Read

Review of oncological emergencies in small animal patients.

Vet Med Sci 2019 Mar 21. Epub 2019 Mar 21.

Veterinary Specialty Center of Delaware, Newcastle, Delaware, USA.

Oncological emergencies can occur at any time during the course of a malignancy and need to be recognized promptly to maximize successful outcomes. Emergencies are characterized as chemotherapy-induced, paraneoplastic syndromes, or directly related to the neoplasm. Prompt identification with treatment of these emergencies can prolong survival and improve quality of life, even in the setting of terminal illness. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/vms3.164
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http://dx.doi.org/10.1002/vms3.164DOI Listing
March 2019
5 Reads

Iatrogenic Hypercalcemia Postrenal Transplantation.

Kidney Int Rep 2019 Mar 19;4(3):487-490. Epub 2018 Nov 19.

Department of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.ekir.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409389PMC
March 2019
1 Read

A randomised controlled trial comparing the efficacy of micellised and fat-soluble vitamin D3 supplementation in healthy adults.

Br J Nutr 2019 Apr 22;121(8):859-865. Epub 2019 Mar 22.

3Department of Dermatology,All India Institute of Medical Sciences,New Delhi 110 029,India.

Nanoemulsion formulation of vitamin D3 have been shown to have better bioavailability than the coarse emulsion preparation in vitro and in vivo animal studies. In the absence of randomised trial in humans, comparing the efficacy of nanotechnology-based miscellised vitamin D3 over conventional vitamin D3, we undertook this study. A total of 180 healthy adults were randomised to receive either micellised (DePura, group A) or conventional vitamin D3 (Calcirol, group B) at a monthly dose of 60 000 IU (1500μg) for 6 months. Read More

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http://dx.doi.org/10.1017/S0007114518003215DOI Listing
April 2019
1 Read
3.453 Impact Factor

A Novel Mutation of the Calcium-Sensing Receptor Gene Causing Familial Hypocalciuric Hypercalcemia Complicates Medical Followup after Roux-en-Y Gastric Bypass: A Case Report and a Summary of Mutations Found in the Same Hospital Laboratory.

Case Rep Endocrinol 2019 13;2019:9468252. Epub 2019 Feb 13.

Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Denmark.

Heterozygous inactivating mutations in the calcium-sensing receptor (CaSR) gene are known to cause familial hypocalciuric hypercalcemia (FHH), usually a benign form of hypercalcemia without symptoms of a disrupted calcium homeostasis. FHH can be mistaken for the more common primary hyperparathyroidism (PHPT), for which surgical treatment may be needed. We describe a case of a 36-year-old woman with hypercalcemia and elevated PTH, initially suspected of having PHPT. Read More

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http://dx.doi.org/10.1155/2019/9468252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393866PMC
February 2019
1 Read

Association of abnormal serum electrolyte levels with hypertension in a population with high salt intake.

Public Health Nutr 2019 Mar 21:1-11. Epub 2019 Mar 21.

2Department of Cardiology,The First Hospital of China Medical University,155 Nanjing Bei Street, Shenyang110001,Liaoning,People's Republic of China.

Objective: The present epidemiological study aimed to evaluate the association of serum electrolyte levels with hypertension in a population with a high-salt diet.

Design: Secondary analysis of epidemiology data from the Northeast China Rural Cardiovascular Health Study conducted in 2012-2013. Blood pressure and hypertension status were analysed for association with serum sodium, potassium, chloride, total calcium, phosphate and magnesium levels using regression models. Read More

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http://dx.doi.org/10.1017/S1368980019000260DOI Listing
March 2019
1 Read
2.679 Impact Factor

A case of Pneumocystis pneumonia, with a granulomatous response and vitamin D-mediated hypercalcemia, presenting 13 years after renal transplantation.

Transpl Infect Dis 2019 Mar 20:e13081. Epub 2019 Mar 20.

Department of Internal Medicine, Division of Infectious Disease, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Vitamin D-mediated hypercalcemia is an uncommon complication of Pneumocystis infection. A granulomatous response resulting from Pneumocystis infection is also atypical. In this report, we describe an exceptional case of granulomatous Pneumocystis pneumonia associated with vitamin D-mediated hypercalcemia, in a patient who presented unusually late after renal transplantation. Read More

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http://dx.doi.org/10.1111/tid.13081DOI Listing
March 2019
2 Reads

Hypercalcemia in Metaplastic Squamous Cell Carcinoma of the Breast.

Am J Case Rep 2019 Mar 20;20:366-369. Epub 2019 Mar 20.

Division of Surgical Oncology, Rush University Medical Center, Chicago, IL, USA.

BACKGROUND Metaplastic breast carcinoma is a rare entity characterized by rapid growth and heterogeneous histological features. It comprises less than 1% of all breast cancers, and no definitive treatment has yet been identified. CASE REPORT We describe here a patient who presented with acute hypercalcemia and was found to have a large ulcerated breast mass. Read More

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https://www.amjcaserep.com/abstract/index/idArt/912427
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http://dx.doi.org/10.12659/AJCR.912427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439960PMC
March 2019
3 Reads

Atypical presentation of pneumonia in a patient with rheumatoid arthritis treated with tofacitinib: a case presentation.

BMC Rheumatol 2018 3;2:34. Epub 2018 Nov 3.

3Department of Rheumatology, Immunology and Rehabilitation, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

Background: We report the case of a patient with rheumatoid arthritis (RA) treated with tofacitinib who developed severe pneumonia (PJP) with an atypical clinical presentation.

Case Presentation: A 78-year old male patient with RA treated with tofacitinib, methotrexate (MTX) and low dose corticosteroids was admitted to the hospital with arthralgia and nausea. Laboratory findings revealed hypercalcemia with normal levels of parathyroid hormone (PTH) and elevated 1,25-(OH) vitamin D levels. Read More

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https://bmcrheumatol.biomedcentral.com/articles/10.1186/s419
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http://dx.doi.org/10.1186/s41927-018-0042-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390573PMC
November 2018
3 Reads