22,330 results match your criteria Hypercalcemia

Vitamin D intoxication induced severe hypercalcemia from self-medication for COVID-19 infection: a public health problem?

Minerva Endocrinol (Torino) 2022 Jul 1. Epub 2022 Jul 1.

Nephrology, Dialysis and Transplantation Unit, Department of Medicine, University of Padova, Padova, Italy -

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Effects of Routine Health Care Combined with Oral Vitamin D on Linear Growth in 5-Year-Old Children.

Evid Based Complement Alternat Med 2022 21;2022:4677795. Epub 2022 Jun 21.

Children Rehabilitation Department of Shiyan Maternal and Child Health Care Hospital, Shiyan, China.

Objective: The aim is to evaluate the effects of routine health care combined with oral vitamin D on linear growth in 5-year-old children.

Materials And Methods: The 5-year-old children who received routine health care in Shiyan Maternal and Child Health Care Hospital from January 2019 to January 2021 were retrospectively analyzed. They were divided into the supplement group and the non-supplement group according to whether or not they received oral vitamin D, and reasons for not taking oral vitamin D and its influence on children's linear growth were analyzed. Read More

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Response and Survival Estimates of Patients With Plasma Cell Myeloma in a Resource-Constrained Setting Using Protocols From High-Income Countries: A Single-Center Experience From Sri Lanka.

JCO Glob Oncol 2022 Jun;8:e2100352

Lanka Hospital Diagnostics, Colombo, Sri Lanka.

Purpose: There is a significant disparity in global cancer care and outcome between countries. Progress in the treatment of symptomatic plasma cell myeloma (PCM) in high-income countries is not seen in low- and middle-income countries.

Materials And Methods: This is was a retrospective cohort study of all patients diagnosed with PCM between May 1, 2013, and September 30, 2021, at the first hemato-oncology center in Sri Lanka. Read More

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Cancer-Associated Hypercalcemia. Reply.

N Engl J Med 2022 Jun;386(26):2540

Yale School of Medicine, New Haven, CT.

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Cancer-Associated Hypercalcemia.

Samuel Lipten

N Engl J Med 2022 Jun;386(26):2540

Massachusetts General Hospital, Boston, MA

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Renal sarcoidosis.

J Nephrol 2022 Jun 27. Epub 2022 Jun 27.

Independent Researcher, via Ampere 126, 20131, Milan, Italy.

Sarcoidosis is a systemic inflammatory disease of unknown etiology. The pathogenesis rests on an aberrant T cell response to unidentified antigens in individuals predisposed by genetic and environmental factors. Increased expression of polarized macrophages and disequilibrium between effector and regulator T cells contribute to the formation of noncaseating granulomas, that are frequently found in affected organs. Read More

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Opportunistic Parathyroid Gland Assessment on Routine CT Could Decrease Morbidity from Undiagnosed Primary Hyperparathyroidism.

Acad Radiol 2022 Jun 24. Epub 2022 Jun 24.

Department of Surgery, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina.

Rationale And Objectives: Gaps in primary hyperparathyroidism diagnosis are well-documented. End-organ damage correlates with disease duration and often occurs before diagnosis. We hypothesize that opportunistic parathyroid gland assessment on routine CT could decrease existing diagnosis gaps. Read More

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Common electrolyte abnormalities in primary care: Hypercalcemia.

Tammy Harris

Nurse Pract 2022 Jul;47(7):24-30

Tammy Harris is Assistant Professor of Nursing and Clinical Coordinator for the MSN Family Nurse Practitioner and Health System Leadership Programs, Campbellsville University, Campbellsville, Kentucky.

Abstract: Hypercalcemia is a frequent and often incidental finding in primary care. The most common causes for hypercalcemia are primary hyperparathyroidism and malignancy. Providers should feel confident in progressing through an initial evaluation with appropriate diagnostics, interventions, and suitable and timely specialty referrals. Read More

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Hypercalcemia and Osteolytic Lesions as Presenting Symptoms of Acute Lymphoblastic Leukemia in Children: Case Report and Literature Review.

Front Pediatr 2022 9;10:923297. Epub 2022 Jun 9.

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.

Acute lymphoblastic leukemia (ALL) presenting with hypercalcemia and osteolytic lesions is rare and unusual in childhood. We report a case of a 13-year-old boy with ALL who presented with intermittent fever, nausea, vomiting, and increasing lower limb pain. Skeletal X-rays and CT scan showed severe osteolytic lesions of the skull and extremities. Read More

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Relation of hyperparathyroidism and hypercalcemia to bipolar and psychotic disorders.

Proc (Bayl Univ Med Cent) 2022 8;35(4):540-542. Epub 2022 Apr 8.

Department of Psychiatry, Houston Methodist Hospital, Houston, Texas.

Primary hyperparathyroidism (PHPT) is characterized by hypercalcemia and an elevated level of serum parathyroid hormone. PHPT leads to hypercalcemia and presents with renal, skeletal, and neuropsychiatric symptoms. Neuropsychiatric manifestations of PHPT such as psychotic, depressive, and anxiety disorders are rare. Read More

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Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):493-497

University of Sharjah, College of Medicine, Clinical Sciences Department, Sharjah, United Arab Emirates.

Context: Primary hyperparathyroidism related hypercalcemic crisis (PHHC) is a condition that may result in fetal course. So, the early diagnosis and treatment of these patients are important.

Objective: This study aimed to investigate the clinical features for hypercalcemic crisis (HC) by comparing the groups with and without primary hyperparathyroidism related calcemic crisis. Read More

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Hypercalcemia in Pregnancy Due to CYP24A1 Mutations: Case Report and Review of the Literature.

Nutrients 2022 Jun 17;14(12). Epub 2022 Jun 17.

Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.

Pathogenic mutations of CYP24A1 lead to an impaired catabolism of vitamin D metabolites and should be considered in the differential diagnosis of hypercalcemia with low parathyroid hormone concentrations. Diagnosis is based on a reduced 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D ratio and confirmed by genetic analyses. Pregnancy is associated with an upregulation of the active vitamin D hormone calcitriol and may thus particularly trigger hypercalcemia in affected patients. Read More

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Bone Metastasis and Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer (NSCLC): Microenvironment and Possible Clinical Implications.

Int J Mol Sci 2022 Jun 20;23(12). Epub 2022 Jun 20.

Dipartimento di Oncologia Medica, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.

Patients with non-small cell lung cancer (NSCLC) develop bone metastasis (BoM) in more than 50% of cases during the course of the disease. This metastatic site can lead to the development of skeletal related events (SREs), such as severe pain, pathological fractures, spinal compression, and hypercalcemia, which reduce the patient's quality of life. Recently, the treatment of advanced NSCLC has radically changed due to the advent of immunotherapy. Read More

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Parathyroid Hormone-Related Peptide (PTHrP): Evaluation of Pediatric, Covariate-Stratified Reference Intervals.

Children (Basel) 2022 Jun 15;9(6). Epub 2022 Jun 15.

Clinical Pathology Unit, AOU Policlinico Consorziale di Bari-Ospedale Giovanni XXIII, 70124 Bari, Italy.

Parathyroid hormone-related peptide (PTHrP) is expressed at a wide range of sites in the body and performs different functions including vasodilation, relaxation of smooth muscle cells, and regulation of bone development. PTHrP also mediates hypercalcemia related to neoplastic diseases. However, reference ranges specific method and age were not evaluated. Read More

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Atypical parathyroid adenoma: Series of two consecutive cases from a tertiary care hospital in Qatar.

Int J Surg Case Rep 2022 Jun 10;96:107296. Epub 2022 Jun 10.

Department of General Surgery, Hamad General Hospital, Doha, Qatar. Electronic address:

Introduction: Atypical parathyroid adenomas (APA) are an uncommon cause of hypercalcemia and comprise a minority of parathyroid adenomas.

Presentation Of Cases: Case 1 - Egyptian male, 48 years old with history of type 2 diabetes mellitus, incidentally discovered increased serum of calcium level on routine investigation, was diagnosed as PHPT, US and MIBI scan showed large left inferior parathyroid adenoma, focused exploration and excision of the APA was undertaken, histopathology confirmed APA. Case 2 - Egyptian male, 60 years old, cardiac patient with history of diabetes, hypertension and multiple cardiac interventions, had nausea, vomiting, constipation abdominal pain, polyuria, polydipsia, and history of passing renal stones, hypercalcemia workup showed primary hyperparathyroidism (PHPT), MIBI was negative and SPECT scan suggested right inferior parathyroid adenoma, focused exploration and excision of the APA was undertaken, histopathology confirmed APA. Read More

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[Hypercalcemia after hyperkalemia].

Ned Tijdschr Geneeskd 2022 Jun 21;166. Epub 2022 Jun 21.

Amphia, afd. Interne Geneeskunde, Breda.

Background: Hyperkalemia is a common yet dangerous phenomenon in patients with chronic kidney disease (CKD). Patients suffering from CKD are therefore often treated with potassium-binding supplements such as calcium polystyrene sulfonate (CPS). Hypercalcemia is a known side effect of CPS. Read More

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Giant cystic parathyroid adenoma: two case reports and a literature review.

J Int Med Res 2022 Jun;50(6):3000605221106419

Department of Endocrinology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, P.R. China.

An uncommon cause of primary hyperparathyroidism is a cystic parathyroid adenoma. This paper describes two patients with hypercalcemia and right knee disease. Their serum calcium concentration was high, phosphorus concentration was low, and parathyroid hormone (PTH) concentration was high. Read More

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A patient with hypercalcemia and hyperparathyroidism due to adenoma mimicking multiple myeloma.

Int J Lab Hematol 2022 Jun 23. Epub 2022 Jun 23.

Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Zhejiang, Hangzhou, China.

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[Malignant hypercalcaemia revealing acute lymphoblastic leukemia: case report].

Pan Afr Med J 2022 29;41:257. Epub 2022 Mar 29.

Service d'Hématologie Clinique, Centre Hospitalier Universitaire Mohammed VI Marrakech, Faculté de Médecine et de Pharmacie, Université Cadi Ayyad, Marrakech, Maroc.

Malignant hypercalcaemia is a metabolic emergency. Its association with solid tumors is common, whereas it has been rarely described in patients with malignant hemopathies other than multiple myeloma and T-cell leukemias/T-cell lymphomas associated with lymphotropic virus type I (HTLV-I). We here report the case of a female patient with acute lymphoblastic leukemia revealed by malignant hypercalcaemia and pathological fracture of the humerus. Read More

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A multi-institutional study evaluating and describing atypical parathyroid tumors discovered after parathyroidectomy.

Laryngoscope Investig Otolaryngol 2022 Jun 19;7(3):901-905. Epub 2022 May 19.

Department of Otolaryngology - Head and Neck Surgery University of Cincinnati College of Medicine Cincinnati Ohio USA.

Objective: To describe common intraoperative and pathologic findings of atypical parathyroid tumors (APTs) and evaluate clinical outcomes in patients undergoing parathyroidectomy.

Methods: In this multi-institutional retrospective case series, data were collected from patients who underwent parathyroidectomy from 2000 to 2018 from three tertiary care institutions. APTs were defined according to the AJCC eighth edition guidelines and retrospective chart review was performed to evaluate the incidence of recurrent laryngeal nerve injury, recurrence of disease, and disease-specific mortality. Read More

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A case of familial hypocalciuric hypercalcemia type 1 due to CASR p.Pro55Leu mutation.

BMC Endocr Disord 2022 Jun 22;22(1):164. Epub 2022 Jun 22.

Department of Diabetes, Endocrinology and Metabolism/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.

Background: Familial hypocalciuric hypercalcemia (FHH) is a rare autosomal dominant disease, which requires differential diagnosis from relatively common primary hyperparathyroidism (PHPT) in order to avoid unnecessary surgery.

Case Presentation: A 16-year-old female had been followed by the department of psychosomatic medicine at our institution. Throughout the follow-up period, her plasma calcium levels were high, plasma Pi levels were relatively low, and plasma intact PTH was relatively high. Read More

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Evolution of gallium applications in medicine and microbiology: a timeline.

Biometals 2022 Jun 21. Epub 2022 Jun 21.

Center of Science and Technology for Sustainability (CCTS), Federal University of São Carlos, Sorocaba, SP, 18052-780, Brazil.

Characterized as a semi-metal, gallium is a chemical element not found freely in the environment, but extracted as a by-product from other minerals. Despite of this, there are several gallium compounds with various applications, such as in the production of semiconductors, light emitting diodes; commercially as a potential cost reducer; pharmacology as cancer-related hypercalcemia, non-Hodgkin' lymphoma, breast and bladder cancer mainly and antimicrobial treatments. The latter will be emphasized in this work due to the contemporary emergence of the development of compounds with antimicrobial potential as a result of the spread of multidrug-resistant bacteria. Read More

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Symptomatic hypercalcaemia following the use of calcium sulfate beads in periprosthetic joint infections.

N Z Med J 2022 Jun 10;135(1556):124-126. Epub 2022 Jun 10.

Department of Orthopaedic Surgery, Canterbury District Health Board.

Calcium sulfate beads (CSBs) are used as a method of delivery of antibiotics in periprosthetic joint infections, non-union and chronic osteomyelitis.[[1-3]] Symptomatic hypercalcaemia can occur as a complication following the insertion of CSBs however it is rare and few cases have been reported.[[4-7]] The cause of hypercalcaemia is poorly understood. Read More

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Modifying Beauty Is Not Priceless: A Rare Case of Silicone-Induced Hypercalcemia With Renal Failure.

Cureus 2022 Jun 13;14(6):e25890. Epub 2022 Jun 13.

Nephrology, Jersey Shore University Medical Center, Neptune City, USA.

Silicone implant-induced hypercalcemia is a rather rare pathological entity. There are only a few published reports on the topic. Here, we have reported a case of acute kidney injury in the background of hypercalcemia and elevated vitamin D level in a transgender patient with a history of silicone injections in the breast and buttocks for cosmetic purposes. Read More

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Parathyroid Crisis as Presentation of Atypical Parathyroid Adenoma: Two Diagnostically Challenging Cases.

J Bone Metab 2022 May 31;29(2):133-140. Epub 2022 May 31.

Department of Endocrinology, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México, Mexico.

Atypical parathyroid adenoma (APA) is a rare cause of primary hyperparathyroidism (PHPT) and represents a diagnostic challenge since it is an intermediate form of parathyroid neoplasm of uncertain malignant potential with atypical histological features that require differential diagnosis of parathyroid carcinoma (PC). We present 2 cases of parathyroid crisis as a presentation of APA. The first case was that of a 56-year-old man with parathyroid crisis, constitutional syndrome, and anemia, with evidence of APA after en bloc resection, evolving with hungry bone syndrome after surgery and curation criteria at 6 months after parathyroidectomy (PTX). Read More

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Electrolyte Abnormalities Associated With the Use of Atezolizumab - A Systematic Review.

J Community Hosp Intern Med Perspect 2022 12;12(2):35-44. Epub 2022 Apr 12.

Department of Internal Medicine, McLaren Flint Michigan State University, Flint, MI, USA.

Background And Objectives: In recent years, immune-checkpoint inhibitors (ICIs) particularly atezolizumab is on the rise in treating advanced malignancies. With its increased clinical use, various electrolyte abnormalities have been reported in the literature. In this review, we have addressed the question of significant electrolyte abnormalities associated with atezolizumab. Read More

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Teriparatide Associated Late Hypercalcemia: A Report of Two Cases and Literature Review.

J Community Hosp Intern Med Perspect 2022 31;12(1):54-58. Epub 2022 Jan 31.

Division of Endocrinology, Department of Medicine, Sinai Hospital of Baltimore, Baltimore, MD 21215, USA.

Introduction: Teriparatide, recombinant human parathyroid hormone (1-34), is a safe and usually well-tolerated medication. We describe two cases of late-onset hypercalcemia associated with teriparatide use and report current evidence of hypercalcemia during the treatment with PTH analogs.

Case Report: Case 1 is a 54-year-old man with a history of osteoporosis, previously treated with 6 months of teriparatide, but had not been consistent in taking the medication. Read More

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January 2022

Elevated parathyroid hormone one year after kidney transplantation is an independent risk factor for graft loss even without hypercalcemia.

BMC Nephrol 2022 Jun 17;23(1):212. Epub 2022 Jun 17.

Department of Transplant and Endocrine Surgery, Japanese Red Cross Nagoya Daini Hospital, 2-9 Myoken-cho, Showa-ku, Nagoya, Aichi, 4668650, Japan.

Background: Hypercalcemic hyperparathyroidism has been associated with poor outcomes after kidney transplantation (KTx). However, the clinical implications of normocalcemic hyperparathyroidism after KTx are unclear. This retrospective cohort study attempted to identify these implications. Read More

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