20,098 results match your criteria Hypercalcemia
Ugeskr Laeger 2018 Nov;180(48)
Paraffin oil injections may cause severe hypercalcaemia, likely due to development of granulomas at injection sites, activating 1,25 dihydroxyvitamin D and increasing calcium uptake from gut, kidney and bone. This is a case report of a 39-year-old male with severe hypercalcaemia and renal failure due to paraffin oil injections. He was treated with prednisolone (25-50 mg daily), but the disease recurred the next two summers probably due to erroneous vitamin D supplement and sun exposure. Read More
Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.
We report a case of a 69-year-old woman with primary hyperoxaluria type I, who developed a severe hypercalcemia despite controlled secondary hyperparathyroidism. Bone scintigraphy showed diffuse increased uptake in axial and peripheral skeleton. F-FDG PET/CT showed countless striking hypermetabolic foci, interesting 2 types of lesions (joint calcifications and periosteal resorptions). Read More
Expert Rev Hematol 2018 Dec 4. Epub 2018 Dec 4.
c Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited , Cambridge , UK.
Background: Triplets with immunomodulators (IMIDs) and proteasome inhibitors (PIs) improve overall survival (OS) in trials of newly diagnosed multiple myeloma (NDMM) patients although reported outcomes in routine practice are lacking. Authors compared outcomes in NDMM patients in the USA by use of triplet vs doublet frontline therapy (FT).
Methods: This is a retrospective electronic health record database study of NDMM patients without transplant in FT between 1/1/2008 and 6/30/2017. Read More
J Electrocardiol 2018 Nov - Dec;51(6):939-940. Epub 2018 Jul 29.
Division of Cardiology, Kingston Health Science Center, Queen's University, Kingston, Ontario, Canada. Electronic address:
An otherwise healthy 64-year-old man with recently diagnosed multiple myeloma was admitted to hospital with hypercalcemia and renal failure. Despite his electrocardiogram showing short QT/QTc intervals, he was admitted without cardiac monitoring. He died suddenly a few hours later, likely from a fatal arrhythmia. Read More
Clin Calcium 2018 ;28(12):1627-1634
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
Primary hyperparathyroidism(PHPT)is one of the common endocrine disorders, which results clinically in secondary osteoporosis. PHPT also occurs nephrolithiasis, muscle weakness, cardiac and psychiatric abnormalities even in a mild or asymptomatic disease. Parathyroidectomy(PTX)is the only definitive treatment for PHPT. Read More
J Intern Med 2018 Nov 28. Epub 2018 Nov 28.
Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Background: Patients with hypoparathyroidism are at risk of both hypocalcemic and hypercalcemic crisis. Patients report that health professionals do not always respond adequately in an acute situation. The extent and handling of severe hypo- and hypercalcemia in hypoparathyroidism is unknown. Read More
Mali Med 2018 ;33(1):6-9
Service de Néphrologie, CHU de Yopougon. Adresse : 21 BP 632 Abidjan 21.
Background: Renal involvement is common during monoclonal gammopathies and their occurrence impacts the survival of the patients. Our objective was to describe the renal features during monoclonal gammopathies from 2004 to 2016 at the University Hospital of Yopougon in Abidjan.
Methods: Renal failure was defined as blood creatinine level > 20 mg/L and/or proteinuria > 500 mg/24 hours. Read More
Case Rep Oncol 2018 Sep-Dec;11(3):705-710. Epub 2018 Nov 1.
Kingsbrook Jewish Medical Center, Department of Medicine and New York Presbyterian - Brooklyn Methodist Hospital, Brooklyn, New York, USA.
Multiple myeloma (MM), a plasma cell neoplasm, has a typical presenting pattern consisting of bone pain, renal failure, anemia, and/or hypercalcemia. Even though MM is a cancer that impairs the immune system, rarely is a systemic infection the first sign of disease. In this case report, our patient presented with altered mental status due to meningitis and was later diagnosed with MM. Read More
Praxis (Bern 1994) 2018 Nov;107(24):1309-1315
1 Innere Medizin/Endokrinologie und Diabetologie, Luzerner Kantonsspital.
CME: Paraneoplastic Endocrine Syndromes Abstract. Paraneoplastic endocrine syndromes are caused by ectopic hormone production by malignant tumor cells. Knowledge of paraneoplastic endocrine syndromes may allow a timely diagnosis of the underlying cancer at a treatable stage and, on the other hand, appropriate treatment of the endocrine manifestations reduces morbidity and mortality of the affected patients. Read More
Acta Clin Belg 2018 Nov 27:1-5. Epub 2018 Nov 27.
c Antwerp University Hospital and University of Antwerp , Edegem.
Objectives: Water and electrolytes disturbances often occur in renal transplant recipients. The objective is to describe the pathophysiology and the treatment of the most prevalent abnormalities.
Methods: We screened PubMed for the following words in various combination: kidney transplantation and (disturbances or abnormalities) of (electrolytes or sodium or potassium or phosphate or calcium or acid-base). Read More
Urol Case Rep 2019 Jan 9;22:67-69. Epub 2018 Nov 9.
Department of Urology, Niigata Prefectural Central Hospital, Shinnancho 205, Jouetsushi, Niigata, 943-0192, Japan.
Clin Med Insights Circ Respir Pulm Med 2018 16;12:1179548418811840. Epub 2018 Nov 16.
Department of Thoracic Surgery, CHU Hassan II, Fès, Morocco.
Although parathyroid ectopy in the mediastinum has been the subject of several publications, its location in the posterior mediastinum is very rarely reported. We report a case of a 69-year-old patient who presented with clinical symptoms of malignant hypercalcemia due to a retrotracheal mediastinal parathyroid adenoma. The surgical excision leads to a quick normalisation of the phosphocalcic balance with improvement of the clinical symptoms. Read More
Best Pract Res Clin Endocrinol Metab 2018 Sep 28. Epub 2018 Sep 28.
Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address:
Primary hyperparathyroidism (PHPT), the most common cause of hypercalcemia, is most often identified in postmenopausal women with hypercalcemia and parathyroid hormone (PTH) levels that are either frankly elevated or inappropriately normal. The clinical presentation of PHPT includes three phenotypes: target organ involvement of the renal and skeletal systems; mild asymptomatic hypercalcemia; and more recently, high PTH levels in the context of persistently normal albumin-corrected and ionized serum calcium values. The factors that determine which of these three clinical presentations is more likely to predominate in a given country include the extent to which biochemical screening is employed, the prevalence of vitamin D deficiency, and whether a medical center or practitioner tends to routinely measure PTH levels in the evaluation of low bone density or frank osteoporosis. Read More
Best Pract Res Clin Endocrinol Metab 2018 Nov 20. Epub 2018 Nov 20.
Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, Division of Medical Genetics, Italy. Electronic address:
Parathyroid tumors represent an elusive endocrine neoplasia, which lead to primary hyperparathyroidism, pHPT, a common endocrine calcium disorder characterized by hypercalcemia and normal-high parathormone secretion. Parathyroid tumours are benign adenomas or multiple glands hyperplasia in the vast majority (>99% of cases), while malignant neoplasms are rare (less than 1%). Despite pHPT is a common disorder, our knowledge about the genetic predisposition and molecular pathophysiology is limited to the familial syndromic forms of parathyroid tumour, that, however, represent not more than the 10% of all the cases; instead, the pathophysiology of sporadic forms remains an open field, although data about epigenetic mechanisms or private genes have been supposed. Read More
J Steroid Biochem Mol Biol 2018 Nov 23. Epub 2018 Nov 23.
National Institutes of Health (NIH) Office of Dietary Supplements (ODS), Bethesda, MD, 20892-7517, USA.
The discovery that mutations of the CYP24A1 gene are a cause of idiopathic infantile hypercalcemia (IIH) has revived interest in measuring serum 24,25(OH)D. Several studies have also suggested that a high 25-hydroxyvitamin D(25-OHD):24,25(OH)D ratio might provide additional diagnostic information in the investigation of vitamin D deficiency. Measurement of 24,25(OH)D is necessarily restricted to laboratories with mass spectrometry methods although cross reactivity of the metabolite in immunoassays for 25-OHD is a potential cause of misleading results. Read More
J Bone Miner Res 2018 Dec 26;33(12):2099-2113. Epub 2018 Nov 26.
Departments of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.
The bone is the third most common site of metastasis for a wide range of solid tumors including lung, breast, prostate, colorectal, thyroid, gynecologic, and melanoma, with 70% of metastatic prostate and breast cancer patients harboring bone metastasis. Unfortunately, once cancer spreads to the bone, it is rarely cured and is associated with a wide range of morbidities including pain, increased risk of fracture, and hypercalcemia. This fact has driven experts in the fields of bone and cancer biology to study the bone, and has revealed that there is a great deal that each can teach the other. Read More
J Pediatr Hematol Oncol 2018 Nov 20. Epub 2018 Nov 20.
Division of Pediatric Hematology/Oncology.
Hand mirror cell (HMC) leukemia is a variant of acute lymphoblastic leukemia previously described in the adult population where lymphoblasts manifest distinctive hand mirror morphologic features. HMC has been previously identified in 23% of childhood acute lymphoblastic leukemia patients, but its prognostic significance in children is not well understood. Hypercalcemia is also uncommon in childhood leukemias. Read More
Urolithiasis 2018 Nov 23. Epub 2018 Nov 23.
UOC Nefrologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Deciding whether to accept a donor with nephrolithiasis is a multifaceted task because of the challenge of finding enough suitable donors while at the same time ensuring the safety of both donors and recipients. Until not long ago, donors with a history of renal stones or with stones emerging during screening on imaging were not considered ideal, but recent guidelines have adopted less stringent criteria for potential donors at risk of stones. This review goes through the problems that need to be approached to arrive at a wise clinical decision, balancing the safety of donors and recipients with the need to expand the organ pool. Read More
Front Endocrinol (Lausanne) 2018 8;9:656. Epub 2018 Nov 8.
Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland.
The numerous evidence showing spectrum of vitamin D effects on human health resulted in both updates of vitamin D supplementation guidelines for general population and concerns on potential risk of hypercalcaemia. The aim of this study was to analyse trends in serum 25-hydroxyvitamin D concentration (25(OH)D) change over the 30 years of operation of a single pediatric diagnostic unit. Calcium-phosphate metabolism markers and 25(OH)D concentrations were analyzed in a group that consisted of newborns and infants commissioned for diagnostics due to suspected calcium-phosphate metabolic disturbances ( = 3,163; mean age 8. Read More
Bone Joint Res 2018 Oct 3;7(10):570-579. Epub 2018 Nov 3.
UCLA Medical Center, Santa Monica David Geffen School of Medicine at UCLA, Los Angeles, USA.
Aims: Calcium sulphate has traditionally been used as a filler of dead space arising during surgery. Various complications have been described following the use of Stimulan bio-absorbable calcium sulphate beads. This study is a prospective observational study to assess the safety profile of these beads when used in revision arthroplasty, comparing the complication rates with those reported in the literature. Read More
Medicine (Baltimore) 2018 Nov;97(47):e13159
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science.
This study aimed to explore the therapeutic efficacy and safety of alfacalcidol among Chinese postmenopausal women (age >65 years) with osteoporosis or osteopenia.A total of 62 postmenopausal women with osteoporosis or osteopenia (>65 years) were recruited from urban residential community of Beijing. The patients daily took oral calcium and alfacalcidol (Alpha D3, 1 μg) for 9 months. Read More
Genet Test Mol Biomarkers 2018 Nov 21. Epub 2018 Nov 21.
2 Division of Endocrinology and Metabolic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University , Istanbul, Turkey .
Aims: Aryl hydrocarbon receptor-interacting protein (AIP) gene mutations have long been associated with apparently sporadic pituitary adenomas (PAs) with a prevalence range of 0-12%. The aim of this study was to evaluate the frequency of germline AIP variations in a large cohort of apparently sporadic PAs diagnosed before the age of 40 years, who did not exhibit hypercalcemia and/or MEN1 syndrome components during long-term follow-up.
Materials And Methods: A total of 97 patients, diagnosed with functional PAs ≤40 years old, composed of somatotropinoma (n = 55), prolactinoma (n = 25), and corticotrophinoma (n = 17), were recruited for this study. Read More
Front Endocrinol (Lausanne) 2018 16;9:618. Epub 2018 Oct 16.
Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
One in 5,000 to 1 in 50,000 births have multiple endocrine neoplasia type 1 (MEN1). MEN1 is a hereditary syndrome clinically defined by the presence of two of the following endocrine tumors in the same patient: parathyroid adenomas, entero-pancreatic endocrine tumors and pituitary tumors. Most commonly, patients with MEN1 manifest primarily with signs and symptoms linked to primary hyperparathyroidism. Read More
Nefrologia 2018 Nov 17. Epub 2018 Nov 17.
Servicio de Nefrología, Hospital Universitario Doce de Octubre, Madrid, España; Departamento de Medicina, Universidad Complutense, Madrid, España.
Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterised by hypercalcaemia and parathormone increase. Decreased glomerular filtration rate (<60ml/min) continues to be a parathyroidectomy (PTX) criterion in asymptomatic PHPT. The influence of PTX on renal function evolution is the subject of debate. Read More
Arch Argent Pediatr 2018 Dec;116(6):e757-e761
Nefrología, Hospital Universitario Virgen Macarena, Sevilla, España.
The finding of persistent hypercalcemia suggests doing other medical tests to find the cause. Familial hypocalciuric hypercalcemia is usually benign and it requires no treatment. It is important to do CASR gene sequencing to avoid unnecessary treatments. Read More
CEN Case Rep 2018 Nov 19. Epub 2018 Nov 19.
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.
A 57-year-old woman with pre-dialysis chronic kidney disease (CKD) was hospitalized because of fever and fatigue. On admission, increased inflammatory response and pyuria with bacteriuria were observed. Pyelonephritis was successfully treated with antibiotics, whereas her fatigue continued and she developed progressive hypercalcemia and hyponatremia; serum sodium level, 116 mEq/L and corrected serum calcium level, 13. Read More
eNeurologicalSci 2018 Dec 2;13:24-25. Epub 2018 Nov 2.
Harvard Medical School, Boston, MA 02115, United States.
Hypercalcemia from tumors has been associated with Posterior Reversible Encephalopathy Syndrome (PRES) but the mechanism remains unclear. In this article, we describe a case of PRES caused by hypercalcemia from lymphoma. We summarize the available scientific evidence linking hypercalcemia to failure of cerebral autoregulation and potentially PRES. Read More
Front Endocrinol (Lausanne) 2018 1;9:641. Epub 2018 Nov 1.
Department of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada.
Parathyroid carcinoma is a rare endocrine malignancy that is typically difficult to diagnose at presentation. Here, we report a 63 year-old man who had symptomatic hypercalcemia. Investigations revealed a thyroid nodule and a lateral neck mass that was biopsied and diagnosed as "suspicious for a neuroendocrine neoplasm. Read More
Intern Med 2018 Nov 19. Epub 2018 Nov 19.
Department of Nephrology, Graduate School of Biomedical Sciences, Tokushima University, Japan.
A 61-year-old man was diagnosed with sarcoidosis involving the lungs, eyes, parotid gland and extrathoracic lymph nodes complicated by chronic kidney injury and hypercalcemia. Kidney biopsy showed non-specific interstitial nephritis and nephrosclerosis. However, immunohistochemical staining of cell surface markers revealed a multinucleated giant macrophage surrounded by T-cells, suggesting granulomatous interstitial nephritis. Read More
Best Pract Res Clin Endocrinol Metab 2018 Oct 18;32(5):621-638. Epub 2018 Jun 18.
Section of Specialized Endocrinology, Division of Medicine, Oslo University Hospital, Norway; Faculty of Medicine, University in Oslo, Oslo, Norway.
Parathyroid independent hypercalcemia is characterized by suppressed parathyroid hormone (PTH) in the presence of hypercalcemia. Well known causes and mechanisms are redistribution of calcium from the skeleton, by malignant diseases; inadequately increased intestinal calcium uptake mediated by increased vitamin D activity, and reduced renal elimination due to medications. Frequent and infrequent causes are discussed, and more recent mechanistic models presented in this review. Read More
Best Pract Res Clin Endocrinol Metab 2018 Oct 26;32(5):609-619. Epub 2018 May 26.
Endocrine Research Unit, San Francisco Veterans Affairs Health Care System, Department of Medicine, University of California, San Francisco, United States. Electronic address:
Familial hypocalciuric hypercalcemia (FHH) causes hypercalcemia by three genetic mechanisms: inactivating mutations in the calcium-sensing receptor, the G-protein subunit α, or adaptor-related protein complex 2, sigma 1 subunit. While hypercalcemia in other conditions causes significant morbidity and mortality, FHH generally follows a benign course. Failure to diagnose FHH can result in unwarranted treatment or surgery for the mistaken diagnosis of primary hyperparathyroidism (PHPT), given the significant overlap of biochemical features. Read More
Best Pract Res Clin Endocrinol Metab 2018 Oct 22;32(5):593-607. Epub 2018 Sep 22.
Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address:
Primary hyperparathyroidism (PHPT), the most common cause of hypercalcemia, is most often identified in postmenopausal women with hypercalcemia and parathyroid hormone (PTH) levels that are either frankly elevated or inappropriately normal. The clinical presentation of PHPT includes three phenotypes: target organ involvement of the renal and skeletal systems; mild asymptomatic hypercalcemia; and more recently, high PTH levels in the context of persistently normal albumin-corrected and ionized serum calcium values. The factors that determine which of these three clinical presentations is more likely to predominate in a given country include the extent to which biochemical screening is employed, the prevalence of vitamin D deficiency, and whether a medical center or practitioner tends to routinely measure PTH levels in the evaluation of low bone density or frank osteoporosis. Read More
Eur J Endocrinol 2018 Nov 1. Epub 2018 Nov 1.
M Brandi, Department of Surgery and Translational Medicine, University of Florence, Florence, 50139, Italy.
Purpose: review calcium homeostasis in pregnancy and provide evidence based best practice recommendations for the management of hypoparathyroidism in pregnancy Methods: We searched MEDLINE, EMBASE and Cochrane databases from January 2000 to April 1, 2018. A total of 65 articles were included in the final review.
Conclusions: During pregnancy calcitriol levels increase by 2-3 fold resulting in enhanced intestinal calcium absorption. Read More
Nat Rev Endocrinol 2018 Nov 15. Epub 2018 Nov 15.
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
The Ca-sensing receptor (CaSR) is a dimeric family C G protein-coupled receptor that is expressed in calcitropic tissues such as the parathyroid glands and the kidneys and signals via G proteins and β-arrestin. The CaSR has a pivotal role in bone and mineral metabolism, as it regulates parathyroid hormone secretion, urinary Ca excretion, skeletal development and lactation. The importance of the CaSR for these calcitropic processes is highlighted by loss-of-function and gain-of-function CaSR mutations that cause familial hypocalciuric hypercalcaemia and autosomal dominant hypocalcaemia, respectively, and also by the fact that alterations in parathyroid CaSR expression contribute to the pathogenesis of primary and secondary hyperparathyroidism. Read More
Dtsch Med Wochenschr 2018 Nov 15;143(23):1702-1704. Epub 2018 Nov 15.
Enzkreiskliniken Mühlacker, Medizinische Klinik.
History: A healthy young woman comes to admission because of an acute renal failure with hypercalcemia.
Findings And Diagnosis: An infective and a non-infective inflammation could be disclosed, as well as a granulomatosis and a myeloma. Drug history was essential for diagnosis. Read More
Eur J Med Genet 2018 Nov 10. Epub 2018 Nov 10.
CHU de Caen, Department of Genetics, Molecular Genetics Laboratory and Reference Center for Rare Diseases of Calcium and Phosphorus Metabolism, Caen, F-14000, France; Université Caen Normandie, Medical School, Caen, F14000, France; BioTARGEN, Université Caen Normandie, Caen, F14000, France.
Loss-of-function mutations in CYP24A1 (MIM 126065 20q13.2), the gene encoding the 24-hydroxylase responsible for 25-OH-D and 1,25-(OH)D degradation, are identified in about 20% of patients presenting Idiopathic Infantile Hypercalcemia (IIH) (MIM 143880). Common features of this autosomal recessive condition included hypercalcemia with hypercalciuria, suppressed PTH and a high 25-OH-D:24,25-(OH)D ratio. Read More
Endocrinol Diabetes Metab Case Rep 2018 Oct;2018(1)
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Reading Hospital, Reading, Pennsylvania, USA.
Summary: A 74-year-old woman presented with progressive lethargy, confusion, poor appetite and abdominal pain. She was found to have non-PTH-mediated severe hypercalcemia with renal failure and metabolic alkalosis. Extensive workup for hypercalcemia to rule out alternate etiology was unrevealing. Read More
Surgery 2018 Nov 9. Epub 2018 Nov 9.
Section of Endocrine Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA.
Background: Patients with primary hyperparathyroidism are at risk for skeletal and renal end-organ damage.
Methods: We studied patients with biochemically confirmed primary hyperparathyroidism from 1995-2014 and quantified the frequency of osteoporosis, nephrolithiasis, hypercalciuria, and decrease in renal function.
Results: The cohort comprised 9,485 patients. Read More
J Oncol Pharm Pract 2018 Nov 12:1078155218812945. Epub 2018 Nov 12.
Department of Pharmacy, Princess Margaret Cancer Centre, Toronto, ON, Canada.
This is a case report of a patient who developed severe, irreversible hypocalcemia after receiving one dose of pamidronate 90 mg for hypercalcemia of malignancy. Hypocalcemia is a known risk of bisphosphonate treatments, but the incidence of severe hypocalcemia is rare, and the risk factors are well established. However, in the treatment of hypercalcemia of malignancy, the treatment objective is to reduce the elevated serum calcium level, and the bisphosphonate is usually given as one time dose only. Read More
QJM 2018 Nov 10. Epub 2018 Nov 10.
Renal medicine, Freeman Hospital, Newcastle Upon Tyne.
QJM 2018 Nov 10. Epub 2018 Nov 10.
University College London Medical School and University College London Hospital.
J Clin Exp Hematop 2018 Nov 9. Epub 2018 Nov 9.
We report a 40-year-old woman who presented with multiple osteolytic bone lesions and hypercalcemia, which are rarely caused by chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Although receiving intensive chemotherapy and allogeneic transplantation, the patient had a poor outcome with an overall survival of 2 years. To our knowledge, this presentation is extremely rare for B-chronic lymphocytic leukemia, and new treatment strategies may be needed for long-term control of the disease. Read More
N Engl J Med 2018 Nov 10. Epub 2018 Nov 10.
From the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School (J.E.M., N.R.C., I.-M.L., W.C., S.S.B., S.M., H.G., D.G., T.C., D.D., G.F., C.R., V.B., E.L.G., W.C.W., J.E.B.), and the Departments of Epidemiology (J.E.M., N.R.C., I.-M.L., W.C.W., J.E.B.) and Nutrition (E.L.G., W.C.W.), Harvard T.H. Chan School of Public Health - all in Boston.
Background: It is unclear whether supplementation with vitamin D reduces the risk of cancer or cardiovascular disease, and data from randomized trials are limited.
Methods: We conducted a nationwide, randomized, placebo-controlled trial, with a two-by-two factorial design, of vitamin D (cholecalciferol) at a dose of 2000 IU per day and marine n-3 (also called omega-3) fatty acids at a dose of 1 g per day for the prevention of cancer and cardiovascular disease among men 50 years of age or older and women 55 years of age or older in the United States. Primary end points were invasive cancer of any type and major cardiovascular events (a composite of myocardial infarction, stroke, or death from cardiovascular causes). Read More
J Urol 2018 Sep 30;200(3):492-494. Epub 2018 May 30.
BMJ 2018 Nov 8;363:k4074. Epub 2018 Nov 8.
Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff, UK.
Eur J Endocrinol 2018 Nov 1. Epub 2018 Nov 1.
L Castaño, Endocrinology and Diabetes Research Group,Cruces University Hospital, CIBERDEM, CIBERER, UPV-EHU, BioCruces Health Research Institute, Barakaldo, Spain.
Objective: Molecular diagnosis is a useful diagnostic tool in calcium metabolism disorders. The calcium-sensing receptor (CaSR) is known to play a central role in the regulation of extracellular calcium homeostasis. We performed clinical, biochemical and genetic characterization of sequence anomalies in this receptor in a cohort of 130 individuals from 82 families with suspected alterations in the CASR gene, one of the largest series described. Read More
Medicine (Baltimore) 2018 Nov;97(45):e13128
Department of Pediatrics.
Rationale: Calcium-sensing receptor (CaSR) mutations can cause life-threatening neonatal severe hyperparathyroidism (NSHPT). The medical management of NSHPT is often challenging and complex. Here, we present a case of NSHPT caused by a novel homozygous CaSR mutation. Read More
Case Rep Rheumatol 2018 11;2018:9746241. Epub 2018 Oct 11.
Division of Hematology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, Arkansas 72205, USA.
Multiple myeloma (MM) is a malignant plasma cell proliferation producing large numbers of monoclonal immunoglobulins. Typical MM symptoms include anemia, renal failure, hypercalcemia, and bone pain. Atypical symptoms have rarely been reported in the literature. Read More
Am J Case Rep 2018 Nov 8;19:1334-1337. Epub 2018 Nov 8.
Fourth Surgical Department, Aristotle University of Thessaloniki, General Hospital "G. Papanikolaou", Thessaloniki, Greece.
BACKGROUND Solitary parathyroid adenomas are the leading cause of primary hyperparathyroidism in 0% to 85% of cases. Diagnosis of parathyroid adenoma is based on typical clinical presentation of hypercalcemia, biochemical profile, and modern imaging studies. The purpose of this article is to present the diagnostic and therapeutic approach used for a 73-year-old female patient with a giant parathyroid adenoma measuring 5×2. Read More