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    Hypercalcemia as a rare presentation of angioimmunoblastic T cell lymphoma: a case report.
    J Med Case Rep 2018 Apr 20;12(1):101. Epub 2018 Apr 20.
    Department of Internal Medicine, Wayne State University School of Medicine, Rochester Hills, MI, USA.
    Background: Angioimmunoblastic T cell lymphoma is a rare malignancy, accounting for only 2% of all non-Hodgkin lymphomas, first described in the 1970s and subsequently accepted as a distinct entity in the current World Health Organization classification. Due to the paucity of this disease, there is still no identifiable etiology, no consistent risk factors, and the pathogenesis remains unclear.

    Case Presentation: An 83-year-old Caucasian man presented to an emergency department with palpitations and was found to have atrial fibrillation. Read More
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    The Use of Low-Calcium Hemodialysis in the Treatment of Hypercalcemic Crisis.
    Nephron 2018 Apr 19. Epub 2018 Apr 19.
    Department of Nephrology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey.
    Background: We reviewed the results of low-calcium hemodialysis (LCHD; 1.25 mmol/L) in the treatment of 42 cases admitting with hypercalcemic crisis.

    Methods: All patients (≥18 years) who started LCHD due to hypercalcemia between 2002 and 2017 were retrospectively analyzed. Read More
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    Aggregation-Induced Emission Probe for Light-Up and in Situ Detection of Calcium Ions at High Concentration.
    ACS Appl Mater Interfaces 2018 Apr 19. Epub 2018 Apr 19.
    Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction , The Hong Kong University of Science & Technology , Clear Water Bay, Kowloon , Hong Kong, China.
    The fluorescent probe for the detection of calcium ions is an indispensable tool in the biomedical field. The millimolar order of Ca(II) ions is associated with many physiological processes and diseases, such as hypercalcemia, soft tissue calcification, and bone microcracks. However, the conventional fluorescent probes are only suitable for imaging Ca(II) ions in the nanomolar to micromolar range, which can be because of their high affinities toward Ca(II) ions and aggregation-caused quenching drawbacks. Read More
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    Synthetic biology-based cellular biomedical tattoo for detection of hypercalcemia associated with cancer.
    Sci Transl Med 2018 Apr;10(437)
    Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.
    Diagnosis marks the beginning of any successful therapy. Because many medical conditions progress asymptomatically over extended periods of time, their timely diagnosis remains difficult, and this adversely affects patient prognosis. Focusing on hypercalcemia associated with cancer, we aimed to develop a synthetic biology-inspired biomedical tattoo using engineered cells that would (i) monitor long-term blood calcium concentration, (ii) detect onset of mild hypercalcemia, and (iii) respond via subcutaneous accumulation of the black pigment melanin to form a visible tattoo. Read More
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    Response to Long-term Vitamin D Therapy for Bone Disease in Children With Sickle Cell Disease.
    J Pediatr Hematol Oncol 2018 Apr 17. Epub 2018 Apr 17.
    Division of Pediatric Endocrinology, Columbia University Medical Center.
    Patients with sickle cell disease (SCD) are at risk for bone fragility from multiple factors including vitamin D deficiency. To date, no studies have evaluated the efficacy and safety of long-term vitamin D therapy for bone disease in children with SCD. We report a cohort of 4 children with SCD found to have severe vitamin D deficiency, secondary hyperparathyroidism, and abnormal bone mineral density treated with monthly high-dose oral cholecalciferol over 2 years. Read More
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    [Hypophosphatemia in preterm infants: a bimodal disorder].
    Rev Chil Pediatr 2018 Feb;89(1):10-17
    Complejo Asistencial Dr. Sótero del Río, Santiago, Chile.
    New nutritional approaches to treat extreme premature babies have demonstrated relevant eviden ce of metabolic disturbances with early hypophosphatemia, especially in patients with intrauterine growth restriction (IUGR). They have shown late hypophosphatemia, as well, which is characteristic in the metabolic bone disease. A sytematic search of literature describing metabolic disturbances of phosphorus in preterm newborns is presented, related to the use of early parenteral nutrition and also in the context of metabolic bone disease. Read More
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    Decrement in bone mineral density after parathyroidectomy in a pediatric patient with primary hyperparathyroidism.
    Clin Pediatr Endocrinol 2018 13;27(2):81-86. Epub 2018 Apr 13.
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Primary hyperparathyroidism (PHT) causes increased bone turnover, leading to reduction in bone mineral density (BMD). Parathyroidectomy is a definitive therapy and improves BMD in adult patients with PHT. However, there are no reports regarding alterations of BMD in pediatric or adolescent patients with PHT. Read More
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    Calcitonin Stewardship Strategies.
    J Pharm Pract 2018 Jan 1:897190018770052. Epub 2018 Jan 1.
    2 Inpatient Operations Supervisor, University of Florida Health Jacksonville, Jacksonville, FL, USA.
    Despite being approved by the Food and Drug Administration for over 30 years, calcitonin salmon has seen a dramatic increase in acquisition cost over the last few years. Being commonly used for the treatment of hypercalcemia of malignancy, health systems must implement stewardship strategies in order to curtail usage. This review is intended to provide a background on calcitonin usage for hypercalcemia of malignancy and associated strategies to ensure appropriateness of utilization within health systems. Read More
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    Identification of Differential Transcriptional Patterns in Primary and Secondary Hyperparathyroidism.
    J Clin Endocrinol Metab 2018 Apr 5. Epub 2018 Apr 5.
    Division of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospitals of Geneva, Switzerland.
    Context: Hyperparathyroidism is associated with hypercalcemia and the excess of parathyroid hormone secretion. However, the alterations in molecular pattern of functional genes during parathyroid tumorigenesis have not been unraveled. We aimed at establishing transcriptional patterns of normal and pathological parathyroid glands (PG) in sporadic primary and secondary hyperparathyroidism (HPT1, 2). Read More
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    Hypercalcemic crisis in third trimenon: evaluating the optimal treatment strategy.
    Gynecol Endocrinol 2018 Apr 16:1-4. Epub 2018 Apr 16.
    a Division of Endocrinology, Diabetes and Metabolism , University Hospital Basel , Switzerland.
    Hypercalcemia due to primary hyperparathyroidism during pregnancy is a rare condition and associated with increased morbidity and mortality for the mother and the unborn child. Whereas parathyroidectomy is favored during the second trimester, no clear recommendations exist for its management during the third trimenon. We here report the case of a 26-year-old woman in the 29th week of her first pregnancy, who was admitted to our clinic with hypertension, intra-uterine growth retardation and polyhydramnios. Read More
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    Refractory hypercalcaemia secondary to localised gastrointestinal stromal tumour.
    Ann R Coll Surg Engl 2018 Apr 16:e1-e3. Epub 2018 Apr 16.
    Whipps Cross University Hospital, Barts Health NHS Trust , London , UK.
    Gastrointestinal stromal tumours are a rare form of intra-abdominal neoplasm derived from mesenchymal tissue, typically presenting with abdominal pain, anaemia or bleeding into the bowel or abdominal cavity. Hypercalcaemia is an unusual complication, having been documented in only seven previous patients, all of whom had advanced metastatic disease. We present a case of treatment-resistant hypercalcaemia in a patient with non-metastatic gastrointestinal stromal tumour, which resolved following excision of the tumour. Read More
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    Primary hyperparathyroidism and Gougerot disease.
    Eur J Rheumatol 2018 Mar 2;5(1):72-74. Epub 2017 Nov 2.
    Department of Endocrinology, Diabetology and Nutrition, University Hospital Hassan II, Fez, Morocco.
    Primary hyperparathyroidism (PHPT) is a common endocrine disorder caused by the overactivation of the parathyroid glands due to the autonomous production of the parathyroid hormone (PTH). The resultant hypercalcemia leads to a myriad of symptoms. Here we report the case of a 54-year-old female with a previous diagnosis of Gougerot disease, in whom clinical (diffuse bone pain, asthenia polydipsia, and polyuria) and laboratory features (calcium level, 3. Read More
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    The When, What & How of Measuring Vitamin D Metabolism in Clinical Medicine.
    Nutrients 2018 Apr 13;10(4). Epub 2018 Apr 13.
    Endocrine Laboratory, Department of Clinical Chemistry, VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
    We now have the ability to measure a number of different vitamin D metabolites with very accurate methods. The most abundant vitamin D metabolite, 25-hydroxyvitamin D, is currently the best marker for overall vitamin D status and is therefore most commonly measured in clinical medicine. The added value of measuring metabolites beyond 25-hydroxyvitamin D, like 1,25-, and 24,25-dihydroxyvitamin D is not broadly appreciated. Read More
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    Hypercalcemia in a bodybuilder with cosmetic silicone injections.
    N Z Med J 2018 Apr 13;131(1473):78-81. Epub 2018 Apr 13.
    Nephrology and Hypertension, Department of Nephrology and Hypertension, Al-Zahraa University Hospital, Beirut, Lebanon.
    Granulomatous hypercalcemia due to silicone injections is a rare disease with scarce literature. We present a case of a 35-year-old Caucasian male bodybuilder with multiple silicone injections in his upper extremities who developed hypercalcemia and urinary symptoms. He necessitated two sessions of dialysis. Read More
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    Severe Hypercalcaemia - Chronic Tophaceous Gout as the Responsible Cause?
    Eur Endocrinol 2015 Aug 19;11(2):102-104. Epub 2015 Aug 19.
    Endocrinology Division, Department of Internal Medicine, University Hospital 'Dr José E González', Unlversldad Autonoma de Nuevo León, Monterrey, México.
    The association of chronic tophaceous gout with severe hypercalcaemia is exceptional. In this case, a 42-year old man with a long-standing history of gout arrived at the emergency room with altered mental status. Laboratory work up revealed a uric acid of 14. Read More
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    The use of PET/CT in pregnancy: A case report of malignant parathyroid carcinoma and a review of the literature.
    Obstet Med 2018 Mar 9;11(1):45-49. Epub 2017 Oct 9.
    1Department of Medicine, University of Alberta, Edmonton, Canada.
    Positron emission tomography scanning is not commonly performed in pregnancy but can be done if required. Fetal doses of radiation can be minimized, and our case exemplifies the safe application of positron emission tomography/computed tomography in pregnancy. A 38-year-old woman in her first ongoing pregnancy presented at 28 weeks' gestation with symptomatic hypercalcemia. Read More
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    Cutaneous complication of perinatal hypoxia.
    Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
    Dermatology Department, Hospital de Santarém EPE, Santarém, Portugal.
    Subcutaneous fat necrosis of the newborn is an uncommon, transient, and self-healing panniculitis, mostly affecting term newborns with perinatal complications. The authors present a case of a female full-term neonate, born from an uncomplicated pregnancy, admitted into the neonatology unit 5 hours after delivery because of refractory multifocal seizures in the context of hypoxic-ischemic encephalopathy. Nine days after birth, indurated and erythematous nodules and plaques were noted on the left arm and back. Read More
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    A Rare Case of Calciphylaxis in an Orthotopic Liver Transplant Recipient with Acute Kidney Injury.
    Exp Clin Transplant 2018 Apr 9. Epub 2018 Apr 9.
    From the Department of Transplant Nephrology, Einstein Medical Center, Philadelphia, Pennsylvania, USA.
    Calciphylaxis is a rare disease characterized by calcification of small- to medium-sized blood vessels in the dermis and subcutaneous fat, resulting in cutaneous necrosis. Although most commonly shown in patients with end-stage kidney disease, it has also been reported in patients with other diseases, including alcoholic cirrhosis and malignancies. Here, we report an unusual case of calciphylaxis in an orthotopic liver transplant recipient with acute kidney injury. Read More
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    Hypercalcemia and acute pancreatitis in a male patient with acute promyelocytic leukemia and pulmonary tuberculosis.
    Acta Biomed 2018 Apr 3;89(3-S):23-27. Epub 2018 Apr 3.
    Hematologists, Department of Hematology, NCCCR, Hamad Medical Corporation (HMC), Doha, Qatar.
    We report a rare case of hypercalcemia and acute pancreatitis in a subject with acute promyelocytic leukemia (APL) and pulmonary tuberculosis, during all-trans-retinoic acid (ATRA) treatment. Both associated complications were potentially due to several causes. A careful monitoring and exclusion of all causative factors must be addressed. Read More
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    Soluble Klotho causes hypomineralization in Klotho-deficient mice.
    J Endocrinol 2018 Apr 9. Epub 2018 Apr 9.
    Y Yoshiko, Oral Grwoth and Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, 734-8553, Japan
    The type I transmembrane protein αKlotho (Klotho) serves as a coreceptor for the phosphaturic hormone fibroblast growth factor 23 (FGF23) in kidney, while a truncated form of Klotho (soluble Klotho, sKL) is thought to exhibit multiple activities, including acting as a hormone, but whose mode(s) of action in different organ systems remains to be fully elucidated. FGF23 is expressed primarily in osteoblasts/osteocytes and aberrantly high levels in the circulation acting via signaling through an FGF receptor (FGFR)-Klotho coreceptor complex cause renal phosphate wasting and osteomalacia. We assessed the effects of exogenously added sKL on osteoblasts and bone using Klotho-deficient () mice and cell and organ cultures. Read More
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    Management of hypercalcaemic crisis in adults: Current role of renal replacement therapy.
    Am J Emerg Med 2018 Mar 7. Epub 2018 Mar 7.
    Nephrology unit, University Hospital Mohammed VI, University Mohammed the First, Oujda, Morocco.
    Neoplasms and hematologic diseases are the predominant etiologies of hypercalcemic crisis in adults and the immediate treatment is mainly medical and symptomatic. The use of renal replacement therapy (RRT) is often necessary to correct the hypercalcemia, uremia and electrolyte disturbances related to Acute Kidney Injury (AKI). The aim of this work was to determine the etiologies and the place of RRT in treating patients with hypercalcaemic crisis. Read More
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    Effect of Lanthanum Carbonate on All-Cause Mortality in Patients Receiving Maintenance Hemodialysis: a Meta-Analysis of Randomized Controlled Trials.
    Kidney Blood Press Res 2018 Mar 29;43(2):536-544. Epub 2018 Mar 29.
    Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
    Background/aims: Hyperphosphatemia is common in patients on hemodialysis. The efficacy of lanthanum carbonate (LC) in the treatment of hyperphosphatemia in these patients remains controversial. The objective of this meta-analysis was to evaluate the effect of LC on all-cause mortality in patients on maintenance hemodialysis. Read More
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    Should total calcium be adjusted for albumin? A retrospective observational study of laboratory data from central Norway.
    BMJ Open 2018 Apr 7;8(4):e017703. Epub 2018 Apr 7.
    Department of Clinical Chemistry, St.Olavs hospital, Trondheim, Norway.
    Objectives: Albumin-adjusted total calcium is often used as a surrogate marker for free calcium to evaluate hypocalcaemia or hypercalcaemia. Many adjustment formulas based on simple linear regression models have been published, and continue to be used in spite of questionable diagnostic accuracy. In the hope of finding a more pure albumin effect on total calcium, we used multiple linear regression models to adjust for other relevant variables. Read More
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    Osteoblast-secreted WISP-1 promotes adherence of prostate cancer cells to bone via the VCAM-1/integrin α4β1 system.
    Cancer Lett 2018 Apr 6;426:47-56. Epub 2018 Apr 6.
    School of Medicine, China Medical University, Taichung, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung, Taiwan; Department of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan. Electronic address:
    Bone metastasis is a frequent occurrence in prostate cancer (PCa) that is associated with severe complications such as fracture, bone pain and hypercalcemia. The cross-talk between metastatic cancer cells and bone is critical to the development and progression of bone metastases. In our previous data, we have described how the involvement of the Wnt-induced secreted protein-1/vascular cell adhesion molecule-1 (WISP-1/VCAM-1) system in this tumor-bone interaction contributes to human PCa cell motility. Read More
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    Bone mineral density in primary care patients related to serum calcium concentrations: a longitudinal cohort study from Sweden.
    Scand J Prim Health Care 2018 Apr 6:1-9. Epub 2018 Apr 6.
    a Institute of Medicine/Dept. of Public Health and Community/Primary Health Care , Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.
    Objective: Elevated calcium concentration is a commonly used measure in screening analyses for primary hyperparathyroidism (pHPT) and cancer. Low bone mineral density (BMD) and osteoporosis are common features of pHPT and strengthen the indication for parathyroidectomy. It is not known whether an elevated calcium concentration could be a marker of low BMD in suspected pHPT patients with a normal parathyroid hormone concentration. Read More
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    Concurrent primary hyperparathyroidism and pheochromocytoma in a Chinese lady with neurofibromatosis type 1.
    Endocrinol Diabetes Metab Case Rep 2018 28;2018. Epub 2018 Mar 28.
    Department of Medicine and Geriatrics, Caritas Medical Centre, Shamshuipo, Kowloon, Hong Kong SAR.
    We report a case of elderly Chinese lady with neurofibromatosis type-1 presenting with longstanding palpitation, paroxysmal hypertension and osteoporosis. Biochemical testing showed mild hypercalcaemia with non-suppressed parathyroid hormone level suggestive of primary hyperparathyroidism, and mildly elevated urinary fractionated normetanephrine and plasma-free normetanephrine pointing to a catecholamine-secreting pheochromocytoma/paraganglioma. Further scintigraphic investigation revealed evidence of a solitary parathyroid adenoma causing primary hyperparathyroidism and a left pheochromocytoma. Read More
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    A rare case of hypercalcemia-induced pancreatitis in a first trimester pregnant woman.
    Endocrinol Diabetes Metab Case Rep 2018 28;2018. Epub 2018 Mar 28.
    Rafic Hariri University Hospital, Beirut, Lebanon.
    The objective of the study is to report a case of acute pancreatitis secondary to hypercalcemia induced by primary hyperparathyroidism in a pregnant woman at the end of the first trimester. The case included a 32-year-old woman who was diagnosed with acute pancreatitis and severe hypercalcemia refractory to many regimens of medical therapy in the first trimester of pregnancy. She was successfully treated with parathyroidectomy in the early second trimester with complete resolution of hypercalcemia and pancreatitis. Read More
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    Esophageal Mucosal Calcinosis: A Rare Site of Gastrointestinal Mucosal Calcinosis.
    Am J Case Rep 2018 Apr 6;19:406-409. Epub 2018 Apr 6.
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
    BACKGROUND Gastrointestinal tract mucosal calcinosis (MC) tends to affect the gastric mucosa, while esophageal involvement is rare. Gastric MC may be seen with solid organ transplantation, use of aluminum-containing antacids or sucralfate, malignancy, and chronic renal failure. While the incidence of gastric MC in renal transplant patients undergoing gastric biopsy is common (between 15-29%), to our knowledge esophageal MC has only been previously reported 3 times. Read More
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    Usefulness of pretransplant aortic arch calcification evaluation for kidney transplant outcome prediction in one year follow-up.
    Ren Fail 2018 Nov;40(1):201-208
    a Clinic of Gastroneterology, Nephrourology and Abdominal Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University , Vilnius , Lithuania.
    Vascular calcification (VC) is linked to post-transplant cardiovascular events and hypercalcemia which may influence kidney graft function in the long term. We aimed to evaluate whether pretransplant aortic arch calcification (AoAC) can predict post-transplant cardiovascular or cerebrovascular events (CVEs), and to assess its association with post-transplant plasma calcium levels and renal function in one-year follow-up. Our single-center observational prospective study enrolled 37 kidney transplant recipients (KTR) without previous history of vascular events. Read More
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    Management of hypercalcaemia-induced heart failure using mechanical circulatory support.
    Eur J Cardiothorac Surg 2018 Mar 30. Epub 2018 Mar 30.
    Department of Cardiology, German Heart Centre Munich, Munich, Germany.
    Acute heart failure is associated with high morbidity and mortality. Heart failure is caused by various conditions, including electrolyte imbalances. We report a rare case of hypercalcaemia-induced acute heart failure complicated by cardiogenic shock. Read More
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    A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro.
    PLoS One 2018 3;13(4):e0195316. Epub 2018 Apr 3.
    Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Kanagawa, Japan.
    Cinacalcet hydrochloride (cinacalcet), an oral calcimimetic agent has been widely used for the management of secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD). In sharp contrast to vitamin D receptor activators, cinacalcet suppresses SHPT without inducing hypercalcemia or hyperphosphatemia. Nevertheless, some patients remain refractory to SHPT with this agent, as the dose cannot be sufficiently increased due to gastrointestinal symptoms. Read More
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    Blue Diaper Syndrome and Mutations.
    Pediatrics 2018 Apr;141(Suppl 5):S501-S505
    Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
    Blue diaper syndrome (BDS) (Online Mendelian Inheritance in Man number 211000) is an extremely rare disorder that was first described in 1964. The characteristic finding is a bluish discoloration of urine spots in the diapers of affected infants. Additional clinical features of the first described patients included diarrhea, inadequate weight gain, hypercalcemia, and nephrocalcinosis. Read More
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    Preterm Parturient with Polyhydramnios and Pancreatitis: Primary Presentation of Hyperparathyroidism.
    Case Rep Obstet Gynecol 2018 21;2018:2091082. Epub 2018 Jan 21.
    Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Objective: To report a case of severe hypercalcemia secondary to primary hyperparathyroidism in a late-preterm pregnant patient and review medical and surgical treatments as well as obstetric and neonatal outcomes.

    Background: Diagnosis of parathyroid disease during pregnancy can be difficult due to nonspecific presentation. Management decisions are complex and require multidisciplinary collaboration. Read More
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    [Disturbances of calcium metabolism and vitamin D supplementation in sarcoidosis - two-way street].
    Pol Merkur Lekarski 2018 Mar;44(261):147-149
    1st Department of Lung Diseases, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
    The role of vitamin D in the human body is not limited only to the regulation of calcium metabolism and secondary to the impact on bones. Recent studies have shown the influence of vitamin D level on muscles, on the risk of cancer, diabetes, hypertension and pulmonary diseases, including granulomatous diseases. Sarcoidosis is a granulomatous disease of unknown etiology. Read More
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    [The diagnostic algorithm of practice in pulmonary and extrapulmonary sarcoidosis].
    Pol Merkur Lekarski 2018 Mar;44(261):101-109
    Department of Pulmonology, Medical University of Gdansk, Poland.
    Sarcoidosis (SA) is a granulomatous multisystem disease of unknown ethiology. Pulmonary, lymphadenopathy, liver, spleen, skin, and bone sarcoidosis are more frequent but also SA of the heart, central nervous system, eye, and hypercalcemia with following kidney failure also occur. Sarcoidosis may co-exist with extrapulmonary forms, which may overtake or precede each other. Read More
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    Insights into calcium-sensing receptor trafficking and biased signalling by studies of calcium homeostasis.
    J Mol Endocrinol 2018 Mar 29. Epub 2018 Mar 29.
    C Gorvin, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland
    The calcium-sensing receptor (CaSR) is a class C G-protein coupled receptor (GPCR) that detects extracellular calcium concentrations, and modulates parathyroid hormone secretion and urinary calcium excretion to maintain calcium homeostasis. The CaSR utilises multiple heterotrimeric G-proteins to mediate signalling effects including: activation of intracellular calcium release; mitogen-activated protein kinase (MAPK) pathways; membrane ruffling; and inhibition of cAMP production. By studying germline mutations in the CaSR and proteins within its signalling pathway that cause hyper- and hypocalcaemic disorders, novel mechanisms governing GPCR signalling and trafficking have been elucidated. Read More
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    Non-parathyroid hypercalcemia associated with paraffin oil injection in 12 younger male bodybuilders.
    Eur J Endocrinol 2018 Mar 29. Epub 2018 Mar 29.
    L Rejnmark, Depatment of endocrinology and internal medicine, Aarhus Universitetshospital, Aarhus, Denmark.
    Introduction: Injection of paraffin oil to augment muscles size is a troubling phenomenon known to cause a foreign-body reaction with formation of granulomas. In a few case-reports, long-term side effects have been reported in terms of hypercalcemia and renal failure.

    Methods: We identified a case series of 12 male bodybuilders presenting with non-parathyroid hypercalcemia who previously had injected paraffin oil to increase muscles size. Read More
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    Long-term effects of low calcium dialysates on the serum calcium levels during maintenance hemodialysis treatments: A systematic review and meta-analysis.
    Sci Rep 2018 Mar 28;8(1):5310. Epub 2018 Mar 28.
    Department of iPS Cell Research & Epigenetic Medicine, Keio University School of Medicine, Tokyo, Japan.
    Hypercalcemia and hyperparathyroidism in patients receiving maintenance hemodialysis (MHD) can cause the progression of cardiovascular diseases (CVD) and mineral bone disorders (MBD). The KDIGO recommends the dialysates with a calcium (Ca) concentration of 1.25-1. Read More
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    Endocrinopathies and renal outcomes in lithium therapy: impact of lithium toxicity.
    QJM 2017 Dec;110(12):821-827
    From the Department of Endocrinology.
    Background: Lithium is the mainstay of treatment for bipolar disorder, mania and an augmentation therapy in patients with treatment resistant depression. It has a narrow therapeutic index, with recognized adverse multi-system and endocrine side effects.

    Aim: To assess the impact of lithium therapy, in particular lithium toxicity, on the development of endocrine and renal disorders in a cohort of patients in a single tertiary referral centre in Ireland. Read More
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    Effects of Serum Albumin, Calcium Levels, Cancer Stage and Performance Status on Weight Loss in Parathyroid Hormone-Related Peptide Positive or Negative Patients with Cancer.
    Endocrinol Metab (Seoul) 2018 Mar;33(1):97-104
    Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Background: A recent animal study showed that parathyroid hormone-related peptide (PTHrP) is associated with cancer cachexia by promoting adipose tissue browning, and we previously demonstrated that PTHrP predicts weight loss (WL) in patients with cancer. In this study, we investigated whether prediction of WL by PTHrP is influenced by clinical factors such as serum albumin, corrected calcium levels, cancer stage, and performance status (PS).

    Methods: A cohort of 219 patients with cancer whose PTHrP level was measured was enrolled and followed for body weight (BW) changes. Read More
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    Localized hepatic tuberculosis presenting as severe hypercalcemia.
    Indian J Tuberc 2018 Apr 22;65(2):172-174. Epub 2017 Aug 22.
    Center for Diabetes and Endocrinology of the state of Pará, Jean Bitar Hospital, Belém, PA, Brazil.
    Hypercalcemia might present itself in association with granulomatous diseases such as tuberculosis. We report a rare case of a 62-year-old man with hypercalcemia due to hepatic tuberculosis. The diagnosis was based on laparoscopic and a histopathological examination. Read More
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    A rapid screening of a recurrent CYP24A1 pathogenic variant opens the way to molecular testing for Idiopathic Infantile Hypercalcemia (IIH).
    Clin Chim Acta 2018 Mar 21;482:8-13. Epub 2018 Mar 21.
    Laboratory of Clinical Pathology and Advanced Molecular Diagnostics, Istituto Dermopatico dell'Immacolata -IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Roma, Italy. Electronic address:
    Introduction: Loss-of-function mutations in cytochrome P450 family 24 subfamily A member 1 (CYP24A1) gene are associated with Idiopathic Infantile Hypercalcemia (IIH) and adult kidney stone disease. The enzyme deficiency leads to an impaired vitamin D catabolism pathway, resulting in a syndrome characterized by recurrent hypercalcemia, hypercalciuria and suppressed parathyroid hormone (PTH) levels. In these patients, the genetic evaluation of CYP24A1 is an important diagnostic tool, allowing the definitive diagnosis of IIH. Read More
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    Clinical value of 11C-methionine positron emission tomography in persistent primary hyperparathyroidism-A case report with a mediastinal parathyroid adenoma.
    Int J Surg Case Rep 2018 Mar 15;45:63-66. Epub 2018 Mar 15.
    Department of Otorhinolaryngology, Aarhus University Hospital, Denmark.
    Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder caused by pathologic growth of one or more of the parathyroid glands. Parathyroidectomies (PTX) in patients with PHPT are procedures with low morbidity, few complications, and a high cure rate. However, the parathyroid glands may be found at various anatomical locations and occasionally they are intrathoracic. Read More
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    Comparison of two melphalan protocols and evaluation of outcome and prognostic factors in multiple myeloma in dogs.
    J Vet Intern Med 2018 Mar 22. Epub 2018 Mar 22.
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706.
    Background: Multiple myeloma (MM) in dogs typically is treated with melphalan. A daily melphalan dosing schedule reportedly is well tolerated and associated with favorable outcome. Although anecdotally a pulse dose regimen has resulted in successful responses, little long-term outcome and safety data is available regarding this dosing regimen for dogs with MM. Read More
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    Menstrual disorders and premenstrual symptoms in adolescents: prevalence and relationship to serum calcium and vitamin D concentrations.
    J Obstet Gynaecol 2018 Mar 21:1-7. Epub 2018 Mar 21.
    e Metabolic Syndrome Research Center , Mashhad University of Medical Sciences , Mashhad , Iran.
    There have been several studies evaluating the association between vitamin and mineral status and menstrual disturbance. In the present study, we aimed to assess the relationship between the menstrual bleeding pattern and premenstrual syndrome (PMS) symptoms with serum 25-hydroxyvitamin D, and calcium levels in adolescent girls. A cross-sectional study was carried out in 897 high school girls from northeastern Iran. Read More
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    Use of calcimimetics in children with normal kidney function.
    Pediatr Nephrol 2018 Mar 19. Epub 2018 Mar 19.
    Bone and Mineral Disorders Clinic, Division of Nephrology, Children's Mercy Hospital, University of Missouri at Kansas City, 2401Gillham Road, Kansas City, MO, 64108, USA.
    The calcium-sensing receptor (CaSR) plays an important role in the homeostasis of serum ionized calcium by regulating parathyroid hormone (PTH) secretion and tubular calcium handling. Calcimimetics, which act by allosteric modulation of the CaSR, mimic hypercalcemia resulting in suppression of PTH release and increase in calciuria. Mostly used in children to treat secondary hyperparathyroidism associated with advanced renal failure, we have shown that calcimimetics can also be successfully used in children with bone and mineral disorders in which elevated PTH plays a detrimental role in skeletal pathophysiology in the face of normal kidney function. Read More
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    Acantholytic squamous cell carcinoma of the lung with marked lymphogenous metastases and high titers of myeloperoxidase-antineutrophil cytoplasmic antibodies: a case report.
    BMC Cancer 2018 03 16;18(1):300. Epub 2018 Mar 16.
    Department of Radiology, Japanese Red Cross Kochi Hospital, 2-13-51, Shinhonmachi, Kochi-city, Kochi, 780-8562, Japan.
    Background: Acantholytic squamous cell carcinoma (ASQCC), histologically characterized by intercellular bridge loosening, is recognized as a rare variant of squamous cell carcinoma (SQCC). ASQCC may demonstrate a worse prognosis than conventional SQCC. Pulmonary ASQCC is particularly rare; its biological behavior and prognostic data have not been reported. Read More
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