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    1 OF 397

    Clinical, biochemical, and pathophysiological analysis of SLC34A1 mutations.
    Physiol Rep 2018 Jun;6(12):e13715
    Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle, United Kingdom.
    Mutations in SLC34A1, encoding the proximal tubular sodium-phosphate transporter NaPi-IIa, may cause a range of clinical phenotypes including infantile hypercalcemia, a proximal renal Fanconi syndrome, which are typically autosomal recessive, and hypophosphatemic nephrolithiasis, which may be an autosomal dominant trait. Here, we report two patients with mixed clinical phenotypes, both with metabolic acidosis, hyperphosphaturia, and renal stones. Patient A had a single heterozygous pathogenic missense mutation (p. Read More

    Neonatal subcutaneous fat necrosis with hypercalcemia treatment using calcitonin.
    Saudi Med J 2018 Jun;39(6):622-626
    Department of Pediatric, Section of Pediatric Critical Care, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia. E-mail.
    Subcutaneous fat necrosis of newborn is a form of noninfectious panniculitis. It is an uncommon condition and mostly occurs in full-term infants within first weeks of life that have had a significant condition such as hypoxic-ischemic encephalopathy at the time of birth. Subcutaneous fat necrosis of newborn is usually a self-limiting condition but may be associated with hypercalcemia, which may lead to life threatening levels. Read More

    Successful treatment of a stage IIIC small-cell carcinoma of the ovary hypercalcemic subtype using multi-modality therapeutic approach.
    Ecancermedicalscience 2018 3;12:832. Epub 2018 May 3.
    Houston Methodist Cancer Centre, Houston Methodist Hospital, Houston, TX 77030, USA.
    Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare but highly undifferentiated, aggressive malignancy that primarily affects young women. Due to its early onset, unclear familial history and vague presenting symptoms, most SCCOHT patients present late with advanced disease. The prognosis is extremely poor, with <10% disease-free survival for advanced stages. Read More

    Tumor-Targeted Nanoparticles Deliver a Vitamin D-Based Drug Payload for Treatment of EGFR Tyrosine Kinase Inhibitor-Resistant Lung Cancer.
    Mol Pharm 2018 Jun 14. Epub 2018 Jun 14.
    Mutation in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene drives the development of lung cancer. EGFR tyrosine kinase inhibitors (EGFR TKI) including erlotinib and afatinib are initially effective in treating EGFR mutant non-small cell lung cancer (NSCLC). However, drug resistance quickly develops due to several mechanisms, including induction of the epithelial-mesenchymal transition (EMT). Read More

    Successful use of cinacalcet to treat parathyroid-related hypercalcemia in two pediatric patients.
    Endocrinol Diabetes Metab Case Rep 2018 6;2018. Epub 2018 Jun 6.
    Department of Pediatric Endocrinology, Children's University Hospital Vall Hebron, Barcelona, Spain.
    Two pediatric patients with different causes of hyperparathyroidism are reported. First patient is a 13-year-old male with severe hypercalcemia due to left upper parathyroid gland adenoma. After successful surgery, calcium and phosphate levels normalized, but parathormone levels remained elevated. Read More

    Rapid calcium loss may cause arrhythmia in hemofiltration with regional citrate anticoagulation: a case report.
    BMC Nephrol 2018 Jun 14;19(1):136. Epub 2018 Jun 14.
    Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
    Background: Renal replacement therapy (RRT) with regional citrate anticoagulation (RCA) is an important therapeutic approach for refractory hypercalcemia complicated with renal failure. However, RCA has the potential to induce arrhythmia caused by rapid calcium loss. We report a case of arrhythmia associated with rapid calcium loss during RCA-RRT. Read More

    Severe Acute Pancreatitis as an Index Clinical Manifestation of Parathyroid Adenoma.
    Cureus 2018 Apr 7;10(4):e2445. Epub 2018 Apr 7.
    Department of Internal Medicine, SBH Health System, 4422 Third Ave, Bronx, Ny 10457.
    Hypercalcemia due to primary or secondary hyperparathyroidism is a rare and obscure cause of acute pancreatitis. Although a rare occurrence to begin with, hyperparathyroidism commonly manifests with symptoms of hypercalcemia. Thus, it would reason that a patient might develop pancreatitis by way of hypercalcemia due to primary or secondary hyperparathyroidism. Read More

    Concomitant sarcoidosis and papillary thyroid cancer with severe hypercalcaemia as the main symptom.
    BMJ Case Rep 2018 Jun 8;2018. Epub 2018 Jun 8.
    Department of Internal Medicine, Randers Regional Hospital, Randers, Denmark.
    A 65-year-old Caucasian man was admitted to our hospital due to incidental finding of plasma ionised calcium=1.83 mmol/L. During the previous months, he had felt more tired and had experienced an unintended weight loss of 6-8 kg. Read More

    Effect of Continuous Intravenous Calcium Loading on Fibroblast Growth Factor 23 in Normal and Uremic Rats.
    Calcif Tissue Int 2018 Jun 7. Epub 2018 Jun 7.
    Division of Nephrology, Department of Medicine, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, Japan.
    Fibroblast growth factor 23 (FGF23) is associated with mortality in patients with CKD. However, the mechanisms underlying stimulation of FGF23 remain to be investigated. We examined whether hypercalcemia induced by continuous intravenous (CIV) calcium (Ca) infusion regulates FGF23 levels in normal rats (Normal) and 5/6 nephrectomized uremic rats (Nx). Read More

    Prevalence and risk factors for hypercalcemia among non-dialysis patients with chronic kidney disease-mineral and bone disorder.
    Int Urol Nephrol 2018 Jun 7. Epub 2018 Jun 7.
    Department of Renal Medicine, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore.
    Purpose: To examine the prevalence and risk factors for hypercalcemia among non-dialysis chronic kidney disease (CKD) patients with mineral and bone disorder (MBD).

    Methods: A retrospective cohort study was conducted in Singapore General Hospital, involving all CKD stage 4 and 5 pre-dialysis patients who were on treatment for MBD in June 2016. Each patient was followed up for 1 year and screened for hypercalcemia episodes. Read More

    Maternal Uniparental Disomy for Chromosome 20: Physical and Endocrinological Characteristics of Five Patients.
    J Clin Endocrinol Metab 2018 Jun;103(6):2083-2088
    Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.
    Context: Maternal uniparental disomy for chromosome 20 [UPD(20)mat], resulting in aberrant expression of imprinted transcripts at the GNAS locus, is a poorly characterized condition. These patients manifested a phenotype similar to that of Silver-Russell syndrome (SRS) and small for gestational age-short stature (SGA-SS); however, the etiological relationship between UPD(20)mat and SRS/SGA-SS remains unclear. Moreover, no report has described endocrinological assessment of UPD(20)mat patients, although paternal UPD(20), the mirror image entity of UPD(20)mat, is known to cause multiple hormone resistance reflecting reduced α-subunit of the stimulatory G protein expression. Read More

    Acute Pancreatitis with Disturbed Consciousness Caused by Hyperparathyroidism.
    Intern Med 2018 Jun 6. Epub 2018 Jun 6.
    Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan.
    Although hyperparathyroidism has been reported to cause acute pancreatitis, little is known about the mechanism involved. This study describes the case of an 86-year-old woman with acute pancreatitis and consciousness disturbance caused by hyperparathyroidism and hypercalcemia, respectively. The consciousness disturbance caused by severe hypercalcemia probably masked the typical symptoms associated with pancreatitis because she did not report abdominal pain during the clinical course. Read More

    Solitary juvenile xanthogranuloma in the spine pretreated with neoadjuvant denosumab therapy followed by surgical resection in a 5-year-old child: case report and literature review.
    Eur Spine J 2018 Jun 6. Epub 2018 Jun 6.
    Department of Orthopedics and Traumatology, Unit of Musculoskeletal Surgery, Tampere University Hospital, Tampere, Finland.
    Purpose: We present a case report that describes neoadjuvant denosumab therapy initiated in a child with a solitary giant cell-rich juvenile xanthogranuloma tumor involving the spine, and review the current literature.

    Methods: A giant cell-rich histiocytic lesion involving the 11th thoracic vertebral body was identified in a healthy 5-year-old girl with persistent back and pelvic pain for several months. Imaging examinations and an open biopsy were performed to obtain a definite pathologic diagnosis. Read More

    [Neonatal cytosteatonecrosis complicated by major hypercalcemia].
    Pan Afr Med J 2018 30;29:86. Epub 2018 Jan 30.
    Laboratoire de Biochimie, CHU Ibn Rochd, Université Hassan II, Casablanca, Maroc.
    We here report the case of a female infant with perinatal asphyxia requiring resuscitation. She was referred with sclerema neonatorum which had been observed by parents on her tenth day of life. The lesions appeared as hard erythematous nodular plaques, suggesting neonatal cytosteatonecrosis in the gluteal region. Read More

    REDUCTION OF ARRHYTHMIAS IN PRIMARY HYPERPARATHYROIDISM, BY PARATHYROIDECTOMY, EVALUATED WITH 24 HOUR ECG MONITORING.
    Eur J Endocrinol 2018 Jun 6. Epub 2018 Jun 6.
    S Minisola, Department of Internal Medicine and Medical Disciplines, "Sapienza" University of Rome, Rome, 00161, Italy.
    Objective: Hypercalcemia may induce arrhythmias. There are no data on the prevalence of arrhythmias in primary hyperparathyroidism (PHPT) in daily life. Aim of the study was to investigate both the prevalence of arrhythmias in patients with PHPT compared to controls and the impact of parathyroidectomy, evaluated by 24 hour electrocardiogram (ECG) monitoring. Read More

    A rural perspective on minimally invasive parathyroidectomy: optimal preoperative imaging and patient outcomes.
    ANZ J Surg 2018 Jun 5. Epub 2018 Jun 5.
    Breast and Endocrine Surgical Unit, Department of Surgery, Wagga Wagga Rural Referral Hospital, Wagga Wagga, New South Wales, Australia.
    Background: Our retrospective review of prospectively collected data evaluated the efficacy of minimally invasive parathyroidectomy (MIP) and compared preoperative imaging modalities in a rural referral centre.

    Methods: Patients with a diagnosis of primary hyperparathyroidism underwent surgeon-performed ultrasound (SUS) and technetium-99 m sestamibi (MIBI). Radiologist-performed ultrasound (RUS) was sought when the diagnosis remained in doubt. Read More

    Gitelman syndrome and primary hyperparathyroidism: a rare association.
    BMJ Case Rep 2018 Jun 5;2018. Epub 2018 Jun 5.
    Department of Endocrinology, Hospital Curry Cabral, Lisboa, Portugal.
    Gitelman syndrome(GS) is a rare autosomal recessive salt-losing tubulopathy of young adults, characterised by hypokalaemia, hypomagnesaemia, hypocalciuria and secondary hyperaldosteronism. Hypercalcaemia due to hypocalciuria in these patients is extremely rare.A 25-year-old healthy woman was referred to the Endocrinology clinic for evaluation of persistent hypokalaemia. Read More

    Pamidronate Rescue Therapy for Hypercalcemia in a Child With Williams Syndrome.
    Front Endocrinol (Lausanne) 2018 14;9:240. Epub 2018 May 14.
    Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
    A 15-month-old male infant diagnosed with Williams Syndrome (WS) was admitted with severe hypercalcemia and nephrocalcinosis. Intravenous hydration and furosemide failed to yield an appreciable and sustainable fall in serum calcium, while the injection of pamidronate achieved a significant decrease in serum calcium in a short period of time. This bisphosphonate could be considered as a second-line treatment for refractory hypercalcemia in WS. Read More

    Treatment of extreme hypercalcaemia: the role of haemodialysis.
    BMJ Case Rep 2018 Jun 4;2018. Epub 2018 Jun 4.
    Department of Nephrology, Soroka University Medical Center, Beer Sheva, Israel.
    A patient with extremely high calcium level of 23.9 mg/dL (5.97 mmol/L) was admitted to our department unconscious with pathological ECG recording, demonstrating shortening of QT interval. Read More

    Beneficial Effects of Concentrated Growth Factors and Resveratrol on Human Osteoblasts Treated with Bisphosphonates.
    Biomed Res Int 2018 16;2018:4597321. Epub 2018 May 16.
    Department of Clinical and Experimental Sciences, Division of Anatomy and Physiopathology, University of Brescia, Brescia, Italy.
    Bisphosphonates are primary pharmacological agents against osteoclast-mediated bone loss and widely used in the clinical practice for prevention and treatment of a variety of skeletal conditions, such as low bone density and osteogenesis imperfecta, and pathologies, such as osteoporosis, malignancies metastatic to bone, Paget disease of bone, multiple myeloma, and hypercalcemia of malignancy. However, long-term bisphosphonate treatment is associated with pathologic conditions including osteonecrosis of the jaw, named BRONJ, which impaired bone regeneration process. Clinical management of BRONJ is controversy and one recent approach is the use of platelet concentrates, such as Concentrated Growth Factors, alone or together with biomaterials or antioxidants molecules, such as resveratrol. Read More

    Cholangiocarcinoma in a Child with Progressive Abdominal Distension and Secondary Hypercalcemia.
    Case Rep Pediatr 2018 23;2018:6828037. Epub 2018 Apr 23.
    Division of Hematology/Oncology, Department of Pediatrics, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand.
    Cholangiocarcinoma is extremely rare in childhood and has been reported in association with other underlying diseases. The survival and prognosis are dismal especially in patients with unresectable or advanced stage cholangiocarcinoma. Overall survival in patients with metastatic cholangiocarcinoma could be increased by using combination chemotherapy with cisplatin and gemcitabine. Read More

    American Thyroid Association Statement on Postoperative Hypoparathyroidism: Diagnosis, Prevention, and Management in Adults.
    Thyroid 2018 May 31. Epub 2018 May 31.
    UCLA, Head & neck surgery, Los Angeles, California, United States ;
    Background: Hypoparathyroidism (hypoPT) is the most common complication after bilateral thyroid operations. Thyroid surgeons must employ strategies for minimizing and preventing post-thyroidectomy hypoPT. The objective of this American Thyroid Association Surgical Affairs Committee Statement is to provide an overview of its diagnosis, prevention and treatment. Read More

    Prevalence and Clinicopathologic Significance of BRAF V600E Mutation in Chinese Multiple Myeloma Patients.
    Clin Lymphoma Myeloma Leuk 2018 May 15. Epub 2018 May 15.
    Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China; State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address:
    Background: Previous studies in Western countries demonstrated BRAF V600E mutation only in a small subset of multiple myeloma (MM) patients. However, the prevalence and clinicopathologic significances of this mutation remain unclear in Chinese MM patients.

    Patients And Methods: We studied diagnostic bone marrow samples from 205 Chinese MM patients by allele-specific PCR to detect BRAF V600E mutation and by high-resolution melting assay to detect KRAS and NRAS mutations. Read More

    The Effects of Diuretics on Mineral and Bone Metabolism.
    Pediatr Endocrinol Rev 2018 Mar;15(4):291-297
    Division of Pediatric Nephrology, Children's Mercy Hospital Kansas City, 2401 Gillham Road, Kansas City, MO, USA, E-mail:
    The effects of diuretics on water and electrolyte metabolism are well-established, but less known to the clinician are their effects on bone and mineral metabolism, and in particular on that of calcium homeostasis. In general, and clinically most relevant, diuretics acting at the thick ascending limb of the loop of Henle cause loss of calcium into the urine, thus making them a useful tool in treating hypercalcemia. However the hypercalciuria caused by loop diuretics may lead to the development of urolithiasis and nephrocalcinosis, as well as secondary hyperparathyroidism and bone disease. Read More

    [Analysis on effects of modified dosage of calcium gluconate on patients with hydrofluoric acid burns not in hands or feet].
    Zhonghua Shao Shang Za Zhi 2018 May;34(5):277-282
    Department of Burns and Plastic Surgery, Zhejiang Quhua Hospital, Quzhou 324004, China.
    To retrospectively explore the effects of modified dosage of calcium gluconate (CG) on the patients with hydrofluoric acid burns not in hands or feet. One hundred and sixty patients with hydrofluoric acid burns not in hands or feet were hospitalized in our burn ward from January 2004 to December 2017. Based on the dosage of CG at different admission time, 76 patients hospitalized from January 2004 to December 2012 were included in traditional group, and 84 patients hospitalized from January 2013 to December 2017 were included in modified group. Read More

    Fluoride induced tissue hypercalcemia, IL-17 mediated inflammation and apoptosis lead to cardiomyopathy: Ultrastructural and biochemical findings.
    Toxicology 2018 May 22;406-407:44-57. Epub 2018 May 22.
    Department of Anatomy, AIIMS, New Delhi, India.
    An increased prevalence of cardiac complications has been observed in residents of fluorosis endemic areas chronically exposed to fluoride. Fluoride induces soft tissue injury due to oxidative stress, lipid peroxidation (LPO) and mitochondriopathy. It was hypothesized that chronic fluoride exposure induces apoptosis in cardiomyocytes due to inflammation, lysis of extra cellular matrix and altered calcium metabolism. Read More

    Effect of levamisole on expression of CD138 and interleukin-6 in human multiple myeloma cell lines.
    Indian J Cancer 2017 Jul-Sep;54(3):566-571
    Department of Biochemistry, Mahatma Gandhi University, Nalgonda, Telangana, India.
    Introduction: Multiple myeloma (MM) is a B-cell malignancy accounting for 0.8% of all cancer deaths globally. This malignancy is characterized by lytic bone disease renal insufficiency, anemia, hypercalcemia, and immunodeficiency. Read More

    Combined Hepatocellular Carcinoma and Neuroendocrine Carcinoma with Ectopic Secretion of Parathyroid Hormone: A Case Report and Review of the Literature.
    J Pathol Transl Med 2018 May 25. Epub 2018 May 25.
    Department of Pathology Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
    Primary combined hepatocellular carcinoma (HCC) and neuroendocrine carcinoma is a rare entity, and so is hypercalcemia due to ectopic parathyroid hormone (PTH) secretion by tumor. A 44-year old male with hepatitis B virus associated chronic liver disease presented with a hepatic mass. Hemihepatectomy discovered the mass as combined HCC and poorly differentiated cholangiocarcinoma. Read More

    Progression of Mineral Ion Abnormalities in Patients with Jansen's Metaphyseal Chondrodysplasia.
    J Clin Endocrinol Metab 2018 May 16. Epub 2018 May 16.
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
    Context: Five different activating PTH/PTHrP receptor (PTHR1) mutations have been reported as causes of Jansen metaphyseal chondrodysplasia (JMC), a rare disorder characterized by severe growth plate abnormalities and PTH-independent hypercalcemia.

    Objectives: Assess the natural history of clinical and laboratory findings in twenty-four JMC patients and characterize the disease-causing mutant receptors in vitro.

    Patients And Methods: The H223R mutation occurred in 18 patients. Read More

    A novel alendronate functionalized nanoprobe for simple colorimetric detection of cancer-associated hypercalcemia.
    Nanoscale 2018 May 22. Epub 2018 May 22.
    School of Materials Science and Engineering, Gwangju Institute of Science and Technology, 123 Cheomdan Gwagi-ro, Oryong dong, Buk-gu, Gwangju 61005, Republic of Korea.
    The calcium (Ca2+) ion concentration in the blood serum is tightly regulated, and any abnormalities in the level of serum calcium ions are associated with many potentially dangerous diseases. Thus, monitoring of the Ca2+ ion concentration in the blood serum is of fundamental importance. Gold nanoparticle (GNP)-based colorimetric biosensors have enormous potential in clinical diagnostic applications due to their simplicity, versatility, and unique optical properties. Read More

    [A young girl with recurrent calculosis and hypercalcemia].
    G Ital Nefrol 2018 May;35(3)
    UOC di Nefrologia Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Roma, Italy.
    Mutations of the CYP24A1 gene are associated with alterations in the activity of the enzyme 25-OH-D-24-hydroxylase, resulting in dysfunction of the metabolism of vitamin D. This enzymatic deficiency may cause hypercalcemia, low parathyroid hormone levels, hypercalciuria, nephrolithiasis and nephrocalcinosis. The clinical case of a young woman with recurrent renal lithiasis, hypercalcemia and hypercalciuria is described. Read More

    Current and potential treatment options for hyperphosphatemia.
    Expert Opin Drug Saf 2018 Jun 21;17(6):597-607. Epub 2018 May 21.
    a Department of Nephrology and Dialysis , A. Manzoni Hospital ASST Lecco , Lecco , Italy.
    Introduction: Hyperphosphatemia is common in late stages of chronic kidney disease and is often associated with elevated parathormone levels, abnormal bone mineralization, extra-osseous calcification, and increased risk of cardiovascular events and death. Several classes of oral phosphate binders are available to help control plasma phosphorus levels. Although effective at lowering serum phosphorus, they all have safety, tolerability, and compliance issues that need to be considered when selecting which one to use. Read More

    Single Ultra-High-Dose Cholecalciferol to Prevent Vitamin D Deficiency in Pediatric Hematopoietic Stem Cell Transplantation.
    Biol Blood Marrow Transplant 2018 May 18. Epub 2018 May 18.
    Division of Endocrinology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio. Electronic address:
    Vitamin D deficiency is prevalent among childhood hematopoietic stem cell transplantation (HSCT) recipients and associated with inferior survival at 100 days after transplantation. Achieving and maintaining therapeutic vitamin D levels in HSCT recipients is extremely challenging in the first 3 to 6 months after transplantation due to poor compliance in the setting of mucositis and the concomitant use of critical transplantation drugs that interfere with vitamin D absorption. We sought to evaluate the safety and efficacy of a single, ultra-high-dose of vitamin D given before childhood HSCT to maintain levels in a therapeutic range during the peritransplantation period. Read More

    [Recurrent urolithiasis as a symptom of primary hyperparathyroidism in a 16-year-old boy].
    Pol Merkur Lekarski 2018 Apr;44(262):208-210
    Medical University of Lublin, Poland: Department of Pediatric Nephrology.
    Primary hyperparathyroidism is one of the most common endocrine diseases, however, it is rare in children. In most cases, it is caused by adenoma of these organs. Its most common complications include urolithiasis, nephrocalcinosis and osteoporosis. Read More

    Potential role of peroxisome proliferator activated receptor gamma activation on serum visfatin and trace elements in high fat diet induced type 2 diabetes mellitus.
    Life Sci 2018 Jul 14;205:164-175. Epub 2018 May 14.
    Department of Biochemistry, University of Karachi, Karachi 75270, Pakistan.
    Aims: Electrolytes and trace elements dysregulation play an important role in the progression of obesity and diabetes complications. The present study was designed to evaluate the insulin sensitizing effects of peroxisomes proliferators activated receptor gamma (PPAR-γ) agonist on trace elements in obesity induced type 2 diabetes mellitus and correlate with serum visfatin.

    Materials And Methods: Wistar rats were categorized into five groups. Read More

    Hypercalcemia and hypophosphatemia among preterm infants receiving aggressive parenteral nutrition.
    Arch Argent Pediatr 2018 06;116(3):e371-e377
    Departamento de Pediatría, Servicio de Neonatología, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires.
    Introduction: Aggressive parenteral nutrition is the standard of care among very-low-birth weight preterm infants. However, in recent studies, its impact on short-term outcomes, has been evaluated. The objective was to compare the prevalence of hypercalcemia and hypophosphatemia among preterm infants receiving aggressive or standard parenteral nutrition. Read More

    Dual Paraneoplastic Endocrine Syndromes Heralding Onset of Extrapulmonary Small Cell Carcinoma: A Case Report and Narrative Review.
    Front Endocrinol (Lausanne) 2018 18;9:170. Epub 2018 Apr 18.
    Division of Endocrinology, Diabetes and Metabolism, Icahn School of Medicine at Mount Sinai, Mount Sinai St. Luke's and West Hospital Center, New York, NY, United States.
    Objective: Extrapulmonary small cell carcinoma (EPSCC) is rare and frequent metastases at presentation can complicate efforts to identify a site of origin. In particular, SCC comprises <1% of prostate cancers and has been implicated in castration resistance.

    Methods: Clinical, laboratory, imaging, and pathology data are presented. Read More

    Denosumab-Associated Severe Hypocalcemia in a Patient With Chronic Kidney Disease.
    Am J Med Sci 2018 May 20;355(5):506-509. Epub 2017 Sep 20.
    Department of Medicine, Division of Nephrology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; FMC Extracorporeal Life Support Center - Fresenius Medical Care, Esztergom, Hungary.
    Denosumab is a monoclonal antibody directed against the receptor activator of nuclear factor kappa B ligand (RANKL). Denosumab has been shown to reduce the risk of skeletal-related events, including spinal cord compression, pathologic fracture and hypercalcemia of malignancy in patients with bone metastases. Hypocalcemia is a known side effect of denosumab, occurring in an estimated 8-14% of the patients. Read More

    Semaphorin 4D correlates with increased bone resorption, hypercalcemia, and disease stage in newly diagnosed patients with multiple myeloma.
    Blood Cancer J 2018 May 11;8(5):42. Epub 2018 May 11.
    Department of Clinical Therapeutics, Alexandra General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
    Multiple myeloma (MM) is characterized by bone destruction due to increased bone resorption and decreased bone formation. Semaphorin 4D (CD100, Sema4D) is expressed by osteoclasts, binds to its receptor Plexin-B1, and acts as a mediator of osteoclast-osteoblast interaction that ultimately inhibits osteoblastic bone formation. Preclinical data suggest that Sema4D/Plexin-B1 pathway is implicated in MM-induced bone disease. Read More

    HTLV-1, ATLL, refractory hypercalcaemia and HIV-1 co-infection.
    Oxf Med Case Reports 2018 Jan 17;2018(1):omx081. Epub 2018 Jan 17.
    Department of Internal Medicine and HIV Clinic, Life Brenthurst Hospital, Johannesburg, South Africa.
    Adult T-cell lymphoma/leukemia (ATLL) is a rare tumour of T-lymphocytes that is associated with human T-lymphotrophic virus type 1 (HTLV-1) infection as well as severe/refractory hypercalcaemia. Human immunodefficiency virus type 1 (HIV-1) infected individuals are at increased risk of acquiring co-infection with HTLV-1. We present the case of a 37 -year -old HIV-1 positive and antiretroviral therapy naive woman who was admitted to the ICU with delirium, a generalised maculopapular rash, severe hypercalcaemia of 4. Read More

    About an aggressive bone lesion.
    Clin Case Rep 2018 May 7;6(5):953-954. Epub 2018 Mar 7.
    Institut National Mohammed Kassab d'Orthopedie La Mannouba Tunisia.
    We report here a case of hyperparathyroidism with disseminated brown tumors mimicking malignancy. The important clinical teaching of our case is that hyperparathyroidism can take various aspects. Plasma parathyroid hormone concentration should be measured in all patients with multiple bone lesions. Read More

    Identification and Functional Characterization of a Novel Mutation in the Human Calcium-Sensing Receptor That Co-Segregates With Autosomal-Dominant Hypocalcemia.
    Front Endocrinol (Lausanne) 2018 25;9:200. Epub 2018 Apr 25.
    Research Centre of Ageing and Osteoporosis, Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark.
    The human calcium-sensing receptor () is the key controller of extracellular Ca homeostasis, and different mutations in the gene have been linked to different calcium diseases, such as familial hypocalciuric hypercalcemia, severe hyperparathyroidism, autosomal-dominant hypocalcemia (ADH), and Bartter's syndrome type V. In this study, two generations of a family with biochemically and clinically confirmed ADH who suffered severe muscle pain, arthralgia, tetany, abdominal pain, and fatigue were evaluated for mutations in the gene. The study comprises genotyping of all family members, functional characterization of a potential mutant receptor by analysis related to the wild-type receptor to reveal an association between the genotype and phenotype in the affected family members. Read More

    Applicability of transoral endoscopic parathyroidectomy through vestibular route for primary sporadic hyperparathyroidism: A South Indian experience.
    J Minim Access Surg 2018 May 4. Epub 2018 May 4.
    Department of Endocrine Surgery, Endocare Hospital, Vijayawada, Andhra Pradesh, India.
    Introduction: Primary hyperparathyroidism is one of the most common endocrine disorders requiring surgical parathyroidectomy for its definitive treatment. Surgical exploration is traditionally performed through conventional open neck approach. A wide range of minimal access and minimally invasive endoscopic techniques (gas less and with gas) have been attempted in the past two decades. Read More

    Osteitis fibrosa cystica masquerading as bone neoplasm.
    BMJ Case Rep 2018 May 7;2018. Epub 2018 May 7.
    Internal Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
    A 50-year-old female patient with no significant medical history presented with left knee pain. Radiographs of the knee showed a circumferential swelling of the distal femur suggestive of neoplasia. Further evaluation revealed multiple lesions in the left iliac bone and proximal femur. Read More

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