1,148 results match your criteria Hyperbilirubinemia Unconjugated


Use of reflective materials during phototherapy for newborn infants with unconjugated hyperbilirubinaemia.

Cochrane Database Syst Rev 2020 Jul 1;7:CD012011. Epub 2020 Jul 1.

Regenerative Medicine Cluster, Advanced Medical and Dentistry Institute, USM, Kepala Batas, Malaysia.

Background: Phototherapy is a well-established effective therapy for treating babies with significant neonatal jaundice. Studies have shown that increasing light intensity will increase its efficiency. A potentially inexpensive and easy way of increasing the intensity of light on the body of the infant may be to hang reflective materials from the sides of phototherapy units. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/14651858.CD012011.pub2DOI Listing

Gilbert's syndrome coexisting with hereditary spherocytosis might not be rare: Six case reports.

World J Clin Cases 2020 May;8(10):2001-2008

Department of Gastroenterology, Nanshan Hospital, Guangdong Medical University, Shenzhen 518052, Guangdong Province, China.

Background: Both Gilbert's syndrome (GS) and hereditary spherocytosis (HS) are common genetic disorders. However, comorbidity of GS with HS has always been considered a rare phenomenon, and it can impede accurate diagnoses in the presence of isolated unconjugated hyperbilirubinemia.

Case Summary: In a study on Levitt's carbon monoxide (CO) breath test for the differential diagnosis of isolated hyperbilirubinemia, we found six GS patients with HS in 6 mo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12998/wjcc.v8.i10.2001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262690PMC

Prediction of the need for phototherapy during hospital stay in preterm infants by transcutaneous bilirubinometry.

Early Hum Dev 2020 Jul 20;146:105029. Epub 2020 May 20.

UCD School of Medicine and Medical Sciences, Dublin, Ireland; Coombe Women and Infants University Hospital, Dublin, Ireland; Institute for the Care of Mother and Child, Prague, Czech Republic; 3rd School of Medicine, Charles University, Prague, Czech Republic. Electronic address:

Background: Neonatal hyperbilirubinemia is a common condition that frequently requires treatment with phototherapy and less commonly by exchange transfusion, especially in preterm infants. It is important to identify and monitor infants at risk of severe unconjugated hyperbilirubinemia early in the postnatal period to instigate appropriate management plans.

Aims: To evaluate transcutaneous bilirubinometry (TCB) as a screening tool at 24 and 48 h of age to predict the need for phototherapy during hospital stay in preterm infants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.earlhumdev.2020.105029DOI Listing

Molecular Physiology and Pathophysiology of Bilirubin Handling by the Blood, Liver, Intestine, and Brain in the Newborn.

Physiol Rev 2020 Jul;100(3):1291-1346

Division of Paediatric and Adolescent Medicine, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; and Department of Pediatrics, Stanford University School of Medicine, Stanford, California.

Bilirubin is the end product of heme catabolism formed during a process that involves oxidation-reduction reactions and conserves iron body stores. Unconjugated hyperbilirubinemia is common in newborn infants, but rare later in life. The basic physiology of bilirubin metabolism, such as production, transport, and excretion, has been well described. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/physrev.00004.2019DOI Listing
July 2020
27.324 Impact Factor

Induction of fecal cholesterol excretion is not effective for the treatment of hyperbilirubinemia in Gunn rats.

Pediatr Res 2020 May 1. Epub 2020 May 1.

Section of Molecular Metabolism and Nutrition, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

Background: Unconjugated hyperbilirubinemia, a feature of neonatal jaundice or Crigler-Najjar syndrome, can lead to neurotoxicity and even death. We previously demonstrated that unconjugated bilirubin (UCB) can be eliminated via transintestinal excretion in Gunn rats, a model of unconjugated hyperbilirubinemia, and that this is stimulated by enhancing fecal fatty acid excretion. Since transintestinal excretion also occurs for cholesterol (TICE), we hypothesized that increasing fecal cholesterol excretion and/or TICE could also enhance fecal UCB disposal and subsequently lower plasma UCB concentrations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41390-020-0926-2DOI Listing

[An update on unconjugated neonatal hyperbilirubinaemia in Denmark].

Ugeskr Laeger 2020 Mar;182(14A)

Approximately 60% of term newborn infants are jaundiced during the first week of life, which is caused by unconjugated bilirubin. Bilirubin encephalopathy is seen with severe hyperbilirubinaemia, when unbound bilirubin crosses the blood-brain barrier. The chronic form is called kernicterus spectrum disorder. Read More

View Article

Download full-text PDF

Source

Blue LED phototherapy in preterm infants: effects on an oxidative marker of DNA damage.

Arch Dis Child Fetal Neonatal Ed 2020 Apr 8. Epub 2020 Apr 8.

Department of Neonatology, Beatrix Children's Hospital, University Medical Centre Groningen, Groningen, The Netherlands.

Background: Phototherapy is used on the majority of preterm infants with unconjugated hyperbilirubinaemia. The use of fluorescent tube phototherapy is known to induce oxidative DNA damage in infants and has largely been replaced by blue light-emitting diode phototherapy (BLP). To date, it is unknown whether BLP also induces oxidative DNA damage in preterm infants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/archdischild-2019-317024DOI Listing

Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota.

Gut Microbes 2020 Jul 30;11(4):1077-1091. Epub 2020 Mar 30.

Microbiome Consortium, Center for Hypertension and Precision Medicine, University of Toledo College of Medicine and Life Sciences , Toledo, OH, USA.

Owing to their health benefits, dietary fermentable fibers, such as refined inulin, are increasingly fortified in processed foods to enhance their nutritional value. However, we previously demonstrated that when inulin was fed to Toll-like receptor 5 deficient (T5KO) mice susceptible to dysbiosis, a subset of them developed cholestasis and subsequently liver cancer in a gut microbiota-dependent manner. Therefore, we hypothesized that clearance of bacterial taxa, and thereby gut metabolites, involved in the onset and progression to liver cancer could abate the disease in these mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/19490976.2020.1743492DOI Listing

Gilbert's Syndrome in Children with Unconjugated Hyperbilirubinemia - An Analysis of 170 Cases.

Indian J Pediatr 2020 Mar 27. Epub 2020 Mar 27.

Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India.

There is limited literature on Gilbert's syndrome (GS) in children with persistent unconjugated hyperbilirubinemia from Indian subcontinent. All patients (< 18 y of age) with genetically confirmed GS were included, and their profile was analysed. A total of 170 subjects were confirmed as having GS as per genetic analysis (133 with homozygous and 37 with heterozygous status). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12098-020-03271-6DOI Listing
March 2020
0.919 Impact Factor

Variants c.864+5G>T and c.996+2_996+5del of a Crigler-Najjar Patient Induce Aberrant Splicing in Minigene Assays.

Front Genet 2020 6;11:169. Epub 2020 Mar 6.

Splicing and Genetic Susceptibility to Cancer, Instituto de Biología y Genética Molecular (CSIC-UVa), Valladolid, Spain.

A large fraction of DNA variants impairs pre-mRNA splicing in human hereditary disorders. Crigler-Najjar syndrome (CNS) is characterized by a severe unconjugated hyperbilirubinemia caused by variants in the gene. We previously reported one CNS-type II patient with two splice-site variants in trans (c. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2020.00169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067894PMC

Relationship between infectious screening and early unconjugated hyperbilirubinemia in well-appearing neonates.

J Chin Med Assoc 2020 Apr;83(4):406-410

Division of Neonatology, Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Background: Neonatal hyperbilirubinemia (NH) may be the initial and solitary sign of infectious condition in neonates. This retrospective cohort study aims to evaluate the risk of sepsis or urinary tract infection in well-appearing infants with NH below 7 days old.

Methods: All neonates (n = 8779) born in Taipei Veterans General Hospital from 2013 to 2017 were evaluated retrospectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JCMA.0000000000000290DOI Listing

Bilirubin disrupts calcium homeostasis in neonatal hippocampal neurons: a new pathway of neurotoxicity.

Arch Toxicol 2020 03 3;94(3):845-855. Epub 2020 Mar 3.

Fondazione Italiana Fegato (FIF), Bldg Q-AREA Science Park Basovizza, SS14 Km 163,5, 34149, Trieste, Italy.

Severe hyperbilirubinemia leads to bilirubin encephalopathy in neonates, causing irreversible neurological sequelae. We investigated the nature of neuronal selective vulnerability to unconjugated bilirubin (UCB) toxicity. The maintenance of intracellular calcium homeostasis is crucial for neuron survival. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00204-020-02659-9DOI Listing

Carbon monoxide breath test assessment of mild hemolysis in Gilbert's syndrome.

Medicine (Baltimore) 2020 Feb;99(7):e19109

Department of Gastroenterology, Nanshan Hospital, Guangdong Medical University.

Background: Mild hemolysis is difficult to determinate by traditional methods, and its role in Gilbert's syndrome (GS) is unclear. The main aims were to inspect the erythrocyte (RBC) survival in GS by using Levitt's carbon monoxide (CO) breath test and to assess its contribution to unconjugated hyperbilirubinemia.

Methods: Fifty subjects with GS and 1 with type-II Crigler-Najjar syndrome (CN2) received RBC lifespan measurement with Levitt's CO breath test. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000019109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035016PMC
February 2020

Enhanced recovery after surgery with intrathecal opioid in a patient of Gilbert's syndrome undergoing mitral valve replacement.

Indian J Anaesth 2020 Jan 7;64(1):66-68. Epub 2020 Jan 7.

Department of Anaesthesia and Intensive Care, PGIMER, Chandigarh, India.

Gilbert's syndrome, an inherited autosomal dominant disorder, is the most common cause of congenital unconjugated hyperbilirubinaemia. We report the anaesthetic management of a 46-year-old female with Gilbert's syndrome operated for mitral valve replacement (MVR), with a special focus on the role of intrathecal opioids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ija.IJA_554_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967366PMC
January 2020

[Consensus on hyperbilirubinemia of the first trimester of life].

Authors:

Arch Argent Pediatr 2020 02;118(1):S12-S49

Neonatal jaundice may be due to different causes, ranging from physiological conditions to severe diseases. In term neonates with persistent jaundice beyond 14 days of life, it should be determined whether hyperbilirubinemia is unconjugated or conjugated, in order to study the etiology and start early treatment. In the majority of cases, conjugated hyperbilirubinemia (cholestasis) is a sign of liver dysfunction possibly associated with alterations in the bile flow secondary to structural or molecular abnormalities of the liver and/or the biliary tract. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5546/aap.2020.S12DOI Listing
February 2020

Effects of hyperbilirubinemia on markers of genotoxicity and total oxidant and antioxidant status in newborns.

Drug Chem Toxicol 2020 Jan 6:1-5. Epub 2020 Jan 6.

Department of Biochemistry, Istanbul Medeniyet University Goztepe Training and Research Hospital, Istanbul, Turkey.

Hyperbilirubinemia is one of the most common diseases in neonates. Slight elevations in bilirubin levels exert antioxidant effects but high levels may cause oxidative damage in newborns. We assessed the effects of hyperbilirubinemia on DNA damage and total oxidant and antioxidant status in newborns receiving phototherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01480545.2019.1710182DOI Listing
January 2020

[A NEW LOOK AT GILBERT SYNDROME (LITERATURE REVIEW)].

Georgian Med News 2019 Nov(296):75-81

Federal state budgetary educational institution of higher education "Astrakhan State Medical University" of the Ministry of health of the Russian Federation, Astrakhan, Russia.

To illuminate modern ideas about Gilbert's syndrome (GS). GS is a common familial hyperbilirubinemia that can reduce the risk of various age-related diseases due to the antioxidant properties of bilirubin. In this case, slightly elevated unconjugated bilirubin in GS is strongly associated with a "reduced" prevalence of chronic diseases, in particular cardiovascular disease (CVD), as well as CVD-related and all-cause mortality. Read More

View Article

Download full-text PDF

Source
November 2019

Genetic Spectrum of in Korean Patients with Unconjugated Hyperbilirubinemia.

Ann Lab Med 2020 May;40(3):281-283

Department of Laboratory Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3343/alm.2020.40.3.281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933057PMC

Combined Effects of Variants on Chinese Adult Mild Unconjugated Hyperbilirubinemia.

Front Genet 2019 31;10:1073. Epub 2019 Oct 31.

Difficult & Complicated Liver Diseases and Artificial Liver Center, Beijing You An Hospital, Capital Medical University, Beijing, China.

The potential for genetic variation to cause adult unconjugated hyperbilirubinemia is increasingly being recognized. However, the cumulative effects of genetic variants have not been fully illuminated. The current study aimed to investigate the effects of uridine diphospho-glucuronosyl transferase 1A1 () and/or solute carrier organic anion transporter family member 1B () polymorphic variants and their combined effects on mild unconjugated hyperbilirubinemia in Chinese adults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2019.01073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834774PMC
October 2019

A critical review on neonatal hyperbilirubinemia-an Ayurvedic perspective.

J Ayurveda Integr Med 2020 Apr - Jun;11(2):190-196. Epub 2019 Oct 15.

Department of Kaumarabhritya, Shri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Udupi, Karnataka, India.

Neonatal hyperbilirubinemia is the elevation of the bilirubin level in the newborns blood, which results in yellowish staining of the skin and sclera of the newborn eyes by pigment of bile. It is due to the breakdown of RBC's (which release bilirubin into the blood) and the immaturity of newborns liver (which cannot effectively metabolize the bilirubin and prepare it for excretion into the urine). Increased bilirubin production, reduced hepatic clearance and enhanced enterohepatic circulation are the sole causes of increased prevalence of jaundice in newborn. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaim.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329719PMC
October 2019
2 Reads

Associations between Neonatal Serum Bilirubin and Childhood Obesity in Term Infants.

Sci Rep 2019 10 10;9(1):14575. Epub 2019 Oct 10.

Department of Neonatology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Inverse correlations between serum bilirubin level and obesity had been reported in adults. We aimed to investigate the associations between neonatal hyperbilirubinemia and childhood obesity. Data was obtained from the U. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-51043-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787235PMC
October 2019
2 Reads

Review of bilirubin neurotoxicity I: molecular biology and neuropathology of disease.

Pediatr Res 2020 01 10;87(2):327-331. Epub 2019 Oct 10.

Department of Pediatrics, Children's Mercy Hospital, Kansas City, MO, USA.

Despite the availability of successful prevention strategies to prevent excessive hyperbilirubinemia, the neurological sequelae of bilirubin neurotoxicity (BNTx) still occur throughout the world. Kernicterus, encephalopathy due to BNTx, is now understood to be a spectrum of severity and phenotypes known as kernicterus spectrum disorder (KSD). A better understanding of the selective neuropathology and molecular biology of BNTx and using consistent clinical definitions of KSDs as outcome measure can lead to more accurately predicting the risk and causes of BNTx and KSDs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41390-019-0608-0DOI Listing
January 2020
1 Read

Effect of on Neonatal Hyperbilirubinemia: A Systematic Review and Meta-analysis.

Iran J Pharm Res 2019 ;18(2):1020-1031

Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

The aim of this systematic review was to evaluate the effect of on the unconjugated hyperbilirubinemia in neonates. Pubmed, Scopus, Chochrane library, Iranmedex and Google scholar were last searched in February 2017. Randomized controlled trials that evaluated the effect of on the treatment of neonatal hyperbilirubinemia were included in the review. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.22037/ijpr.2019.2388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706735PMC
January 2019
1 Read

Prevalence and Relevance of Pre-Existing Anti-Adeno-Associated Virus Immunity in the Context of Gene Therapy for Crigler-Najjar Syndrome.

Hum Gene Ther 2019 10;30(10):1297-1305

Genethon, Evry, France.

Adeno-associated virus (AAV) vector-mediated gene therapy is currently evaluated as a potential treatment for Crigler-Najjar syndrome (CN) (NCT03466463). Pre-existing immunity to AAV is known to hinder gene transfer efficacy, restricting enrollment of seropositive subjects in ongoing clinical trials. We assessed the prevalence of anti-AAV serotype 8 (AAV8) neutralizing antibodies (NAbs) in subjects affected by CN and investigated the impact of low NAb titers (<1:5) on liver gene transfer efficacy in an passive immunization model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/hum.2019.143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763963PMC
October 2019
1 Read

Disease burden of Crigler-Najjar syndrome: Systematic review and future perspectives.

J Gastroenterol Hepatol 2020 Apr 24;35(4):530-543. Epub 2019 Oct 24.

Audentes Therapeutics, San Francisco, CA, USA.

Background And Aim: Crigler-Najjar syndrome (CNS) results from biallelic mutations of UGT1A1 causing partial or total loss of uridine 5'-diphosphate glucuronyltransferase activity leading to unconjugated hyperbilirubinemia and its attendant risk for irreversible neurological injury (kernicterus). CNS is exceedingly rare and has been only partially characterized through relatively small studies, each comprising between two and 57 patients.

Methods: A systematic literature review was conducted to consolidate data on the patient, caregiver, and societal burden of CNS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.14853DOI Listing
April 2020
7 Reads

Analysis of the Genotype in Hyperbilirubinemia Patients: Differences in Allele Frequency and Distribution.

Biomed Res Int 2019 29;2019:6272174. Epub 2019 Jul 29.

Department of Infectious Disease (Liver Diseases), The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.

Objective: The spectrum of () variants in hereditary unconjugated hyperbilirubinemia varies markedly between different ethnic populations. This study evaluated the genotypes in hyperbilirubinemia patients from southeastern China.

Methods: We enrolled 60 patients from southeastern China (44 men and 16 women; age range: 3-76 years) with unconjugated hyperbilirubinemia and performed genetic analysis of the gene by direct sequencing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/6272174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699345PMC
January 2020
3 Reads

Acute kidney injury due to acute cortical necrosis following vivax malaria.

Saudi J Kidney Dis Transpl 2019 Jul-Aug;30(4):960-963

Department of Nephrology, Army Hospital Research and Referral, New Delhi, India.

Malaria is a parasitic infection of global importance but has a high prevalence in the developing countries. Renal failure is a common complication of severe Plasmodium falciparum malaria and has been reported in up to 40% of all cases. Acute kidney injury (AKI), however, is not commonly associated with Plasmodium vivax infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/1319-2442.265474DOI Listing
February 2020
2 Reads

Profiling of UGT1A16, UGT1A160, UGT1A193, and UGT1A128 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing.

Front Pediatr 2019 7;7:328. Epub 2019 Aug 7.

Division of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.

Single nucleotide polymorphism (SNP) variants of the uridine diphosphate glucuronosyltransferase 1A1 () gene have been studied as an important factor in neonatal hyperbilirubinemia (jaundice) severity. Specific ethnicities, including Asians, have certain SNPs that appear more frequently than others. To identify the most common SNPs in Indonesian neonates and their association with the severity of neonatal hyperbilirubinemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fped.2019.00328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693044PMC
August 2019
1 Read

Prebiotics for the prevention of hyperbilirubinaemia in neonates.

Cochrane Database Syst Rev 2019 08 13;8:CD012731. Epub 2019 Aug 13.

Division of Neonatology, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Hyperbilirubinaemia occurs in approximately two-thirds of all newborns during the first days of life and is frequently treated with phototherapy. Although generally seen as safe, there is rising concern regarding phototherapy and its potentially damaging effects on DNA and increased side effects particularly for preterm infants. Other methods, such as enteral feeding supplementation with prebiotics, may have an effective use in the management of hyperbilirubinaemia in neonates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/14651858.CD012731.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699678PMC
August 2019
2 Reads

Circadian Clock Gene Bmal1 Regulates Bilirubin Detoxification: A Potential Mechanism of Feedback Control of Hyperbilirubinemia.

Theranostics 2019 9;9(18):5122-5133. Epub 2019 Jul 9.

Reserach Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.

Controlling bilirubin to a low level is necessary in physiology because of its severe neurotoxicity. Therefore, it is of great interest to understand the regulatory mechanisms for bilirubin homeostasis. In this study, we uncover a critical role for circadian clock in regulation of bilirubin detoxification and homeostasis. Read More

View Article

Download full-text PDF

Source
http://www.thno.org/v09p5122.htm
Publisher Site
http://dx.doi.org/10.7150/thno.35773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691581PMC
July 2019
1 Read
7.827 Impact Factor

Impact of Cytokine Adsorption Treatment in Liver Failure.

Transplant Proc 2019 Sep 9;51(7):2420-2424. Epub 2019 Aug 9.

Department of Anesthesiology and Reanimation, Surgical Intensive Care Unit, Şişli Florence Nightingale Hospital, Istanbul Bilim University, Istanbul, Turkey.

Sepsis causes life-threatening organ dysfunction and is the leading cause of morbidity and mortality in critically ill patients worldwide. Mortality rate of sepsis is close to 30% to 50% despite better understanding of the pathophysiology of sepsis, and advances in antimicrobial therapy, resuscitation strategies, and mechanical ventilation. Liver failure is characterized by accumulation of potentially toxic substances in the systemic circulation of the patient. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00411345183171
Publisher Site
http://dx.doi.org/10.1016/j.transproceed.2019.01.167DOI Listing
September 2019
4 Reads

Amount of Cycloserine Emanating from Terizidone Metabolism and Relationship with Hepatic Function in Patients with Drug-Resistant Tuberculosis.

Drugs R D 2019 Sep;19(3):289-296

School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville, Cape Town, 7535, South Africa.

Background And Objectives: The dosing of cycloserine and terizidone is the same, as both drugs are considered equivalent or used interchangeably. Nevertheless, it is not certain from the literature that these drugs are interchangeable. Therefore, the amount of cycloserine resulting from the metabolism of terizidone and the relationship with hepatic function were determined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40268-019-00281-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738357PMC
September 2019
4 Reads

UGT1A1 mutations and psychoses: towards understanding the relationship with unconjugated bilirubin.

CNS Spectr 2019 Jul 24:1-3. Epub 2019 Jul 24.

School of Medicine and Surgery, University of Milano-Bicocca,Monza,Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1092852919001251DOI Listing
July 2019
4 Reads

Nineteenth-Century Homeopathic Repertories Predict Increased Urinary Excretion of Bile in Cholestasis but Not in Non-Cholestatic Infant Jaundice.

Authors:
Janice Block

Homeopathy 2019 11 22;108(4):270-276. Epub 2019 Jul 22.

Merkaz HaBriut, Center for Integrative Medicine, Ramat Beit Shemesh, Israel.

Introduction: There are two types of bilirubin: conjugated bilirubin, prevalent in cholestatic jaundice, and unconjugated bilirubin, prevalent in hematologic jaundice. Conjugated bilirubin is water soluble and is excreted in urine, whereas unconjugated bilirubin is neither water soluble nor excreted in urine. Homeopathic repertories published prior to the discovery of the two types of bilirubin in 1913 present an opportunity to test the reliability of homeopathic repertories and associated materia medica. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1691835DOI Listing
November 2019
2 Reads

Associations between neonatal serum bilirubin and childhood hypertension.

PLoS One 2019 18;14(7):e0219942. Epub 2019 Jul 18.

Department of Neonatology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Mild hyperbilirubinemia is inversely associated with cardiometabolic diseases in adults. The aim of this study was to evaluate the association between neonatal serum bilirubin levels and childhood hypertension. Data were obtained from the U. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219942PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638957PMC
March 2020
2 Reads

Caspase-1 involves in bilirubin-induced injury of cultured rat cortical neurons.

Pediatr Res 2019 10 13;86(4):492-499. Epub 2019 Jun 13.

Department of Neonatology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, 400014, Chongqing, China.

Background: Bilirubin encephalopathy, the most serious complication of hyperbilirubinemia during the neonatal period, with high mortality and morbidity, often causes irreversible neurological damage. Currently, caspase-1, a member of the cysteinyl aspartate-specific protease caspase family, is regarded as a key mediator of inflammatory processes, attracting widespread attention. The purpose of this study was to investigate whether caspase-1 is involved in bilirubin-induced neuronal injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41390-019-0451-3DOI Listing
October 2019
7 Reads

Comparison of light-emitting diodelights vs fluorescent light phototherpy for the treatment of unconjugated hyperbilirubinemia in preterm infants - Randomised Control Trial.

J Pak Med Assoc 2019 Jun;69(6):767-771

Allied Hospital Faisalabad.

Objective: To compare the mean treatment duration of phototherapy when done with light-emitting diodelights versus fluorescent lights for the treatment of unconjugated hyperbilirubinaemia in preterm infants.

Methods: The randomised controlled trial was conducted at Allied Hospital, Faisalabad, Pakistan, from September 12, 2015, to March 11, 2016, and comprised patients with unconjugated hyperbilirubinaemia. Detailed history, including demographic information, were noted. Read More

View Article

Download full-text PDF

Source
June 2019
6 Reads

Spectrum of UGT1A1 variants in Pakistani children affected with inherited unconjugated hyperbilirubinemias.

Clin Biochem 2019 Jul 27;69:30-35. Epub 2019 May 27.

Medical Genetics Research Laboratory, Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address:

Inherited unconjugated hyperbilirubinemias are a group of disorders characterized by increased levels of serum unconjugated bilirubin and arise because of the imbalance between its production and elimination from the body. It includes Crigler-Najjar syndrome and Gilbert syndrome. Crigler-Najjar syndrome type 1 represents the extreme severe end of the spectrum with complete absence of hepatic bilirubin uridine diphosphoglucuronate glucuronosyltransferase (UGT1A1). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinbiochem.2019.05.012DOI Listing
July 2019
33 Reads
2.229 Impact Factor

A novel UGT1A1 gene mutation causing severe unconjugated hyperbilirubinemia: a case report.

BMC Pediatr 2019 05 29;19(1):173. Epub 2019 May 29.

Amsterdam UMC, University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Meibergdreef 69-71, 1105 BK, Amsterdam, The Netherlands.

Background: Crigler-Najjar syndrome (CNs) presents as unconjugated hyperbilirubinemia, as a result of UGT1A1 deficiency, and can be categorized in a severe (type I) and mild (type II) phenotype. CNs type II patients usually benefit from phenobarbital treatment that induces residual UGT1A1 activity.

Case Presentation: Here we present a CNs type II patient that is not responsive to phenobarbital treatment, which can be explained by two heterozygous mutations in the UGT1A1 gene. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1555-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540546PMC
May 2019
36 Reads

Hyperbilirubinemia in Gunn Rats is Associated with Decreased Inflammatory Response in LPS-Mediated Systemic Inflammation.

Int J Mol Sci 2019 May 9;20(9). Epub 2019 May 9.

Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague 12108, Czech Republic.

Decreased inflammatory status has been reported in subjects with mild unconjugated hyperbilirubinemia. However, mechanisms of the anti-inflammatory actions of bilirubin (BR) are not fully understood. The aim of this study is to assess the role of BR in systemic inflammation using hyperbilirubinemic Gunn rats as well as their normobilirubinemic littermates and further in primary hepatocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20092306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539717PMC
May 2019
6 Reads

Screening and treatment to reduce severe hyperbilirubinaemia in infants in primary care (STARSHIP): a factorial stepped-wedge cluster randomised controlled trial protocol.

BMJ Open 2019 04 20;9(4):e028270. Epub 2019 Apr 20.

Division of Neonatology, Department of Paediatrics, Erasmus MC - Sophia Children's Hospital, University Medical Centre Rotterdam, Rotterdam, Netherlands.

Introduction: Jaundice caused by hyperbilirubinaemia is a physiological phenomenon in the neonatal period. However, severe hyperbilirubinaemia, when left untreated, may cause kernicterus, a severe condition resulting in lifelong neurological disabilities. Although commonly applied, visual inspection is ineffective in identifying severe hyperbilirubinaemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-028270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500291PMC
April 2019
21 Reads

Interference in the anti-Xa heparin activity assay due to hemolysis and icterus during pediatric extracorporeal life support.

Artif Organs 2019 Sep 16;43(9):880-887. Epub 2019 May 16.

Department of Laboratory Medicine, University of Washington, Seattle, Washington.

Chromogenic anti-Xa assays for unfractionated heparin monitoring (heparin activity) are susceptible to interference from hemolysis and icterus. The purpose of this study was to better understand the effect of hemolysis and icterus on anti-Xa heparin activity and to predict the magnitude of the error. Increasing levels of hemoglobin and unconjugated bilirubin were added to pooled normal plasma or buffer containing known levels of heparin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aor.13467DOI Listing
September 2019
3 Reads

Unconjugated bilirubin and schizophrenia: a systematic review.

CNS Spectr 2019 12;24(6):577-588

Clínica Universitária de Psiquiatria e Psicologia Médica, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.

Schizophrenia is a complex syndrome of unknown etiology and difficult to manage. Unconjugated bilirubin has been researched as a potential biological marker of this syndrome. The objective of this review article was to gather the studies published to date on the relationship between this molecule and schizophrenia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S109285291800161XDOI Listing
December 2019
8 Reads

A 12-week rescue therapy by PrOD-based regimen for advanced fibrotic genotype-1 CHC patients who failed to pegylated interferon plus ribavirin.

J Chin Med Assoc 2019 Mar;82(3):186-190

Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Background: Treatment of chronic hepatitis C (CHC) evolved rapidly due to the invention of interferon-free direct antiviral agents. Previous clinical trials showed combination therapy with paritaprevir/ritonavir, ombitasvir, and dasabuvir (PrOD) with or without ribavirin (RBV) can cure over 95% of genotype 1 CHC patients, regardless with cirrhosis or not. However, real-world data regarding the efficacy and safety of PrOD-based therapy in Asian HCV genotype 1 CHC patients are limited, especially for advanced-fibrotic patients who failed previous therapy with pegylated interferon (PEG-IFN) plus RBV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JCMA.0000000000000069DOI Listing
March 2019
7 Reads

Easy Diagnosis of Jaundice: A Smartphone-Based Nanosensor Bioplatform Using Photoluminescent Bacterial Nanopaper for Point-of-Care Diagnosis of Hyperbilirubinemia.

ACS Sens 2019 04 29;4(4):1063-1071. Epub 2019 Mar 29.

Chemistry and Chemical Engineering Research Center of Iran , 14335-186 , Tehran , Iran.

One of the concerns of parents in the first days of their baby's birth is the baby's risk of jaundice/hyperbilirubinemia. This is because more than 60% of babies are born with jaundice that, if not timely diagnosed and subsequently treated, can lead to serious damage to their health. On the other hand, despite recent progress in sensor technology for clinical applications, the development of easy-to-use, cost-effective, sensitive, specific, and portable diagnostic devices, which use nontoxic and biodegradable materials in their design and fabrication, is still in high demand. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acssensors.9b00275DOI Listing
April 2019
13 Reads

A case of accidental neonatal paracetamol overdose with prolonged half-life and measured metabolites.

Clin Toxicol (Phila) 2019 Dec 11;57(12):1154-1156. Epub 2019 Mar 11.

Monash Toxicology Unit and Emergency Medicine Service, Monash Health, Victoria, Australia.

Limited data exist regarding paracetamol metabolism after overdose in the neonate. We report a case of repeated supratherapeutic overdose in a neonate with paracetamol metabolite concentrations. A 10-day-old male neonate presented to hospital after repeated supratherapeutic dosing of paracetamol. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15563650.2019.1587450DOI Listing
December 2019
7 Reads
3.122 Impact Factor