29,594 results match your criteria Hyperbilirubinemia Unconjugated


High unbound bilirubin for age: a neurotoxin with major effects on the developing brain.

Pediatr Res 2018 Dec 5. Epub 2018 Dec 5.

Keck School of Medicine of University of Southern California, Division of Neonatology, Department of Pediatrics, LAC+USC Medical Center, Los Angeles, CA, USA.

Neonatal hyperbilirubinemia is one of the most frequent diagnoses made in neonates. A high level of unconjugated bilirubin that is unbound to albumin is neurotoxic when the level exceeds age-specific thresholds or at lower levels in neonates with neurotoxic risk factors. Lower range of unbound bilirubin results in apoptosis, while moderate-to-high levels result in neuronal necrosis. Read More

View Article
December 2018
1 Read

Delayed bilhemia complicating percutaneous transhepatic biliary drainage: Successful treatment with primary coil embolization.

Radiol Case Rep 2019 Feb 27;14(2):269-272. Epub 2018 Nov 27.

Department of Diagnostic and Interventional Radiology, Istanbul Training and Research Hospital, Istanbul, 34098, Turkey.

Bilhemia is very rare and serious complication of percutaneous transhepatic biliary drainage (PBD). Bile leakage occurs into the bloodstream through a fistula between the biliary tree and the hepatic venous system. We report a case of a 45-year-old woman with bilhemia complicated by PBD. Read More

View Article
February 2019
1 Read

Selected Risk Factors of Developmental Delay in Polish Infants: A Case-Control Study.

Int J Environ Res Public Health 2018 Dec 2;15(12). Epub 2018 Dec 2.

Department of Epidemiology and Management, Pomeranian Medical University, 71-210 Szczecin, Poland.

Despite a number of studies on the risk factors of developmental delay (DD) in children conducted in developed countries, Polish data are scarce, which hinder an early diagnosis and initiation of prevention/control measures. Objective: To assess selected risk factors of DD in infants. A case-control survey was conducted in 2017⁻2018 on 50 infants (≤1 year old) with DD and 104 healthy controls from three outpatient clinics in Szczecin, Poland. Read More

View Article
December 2018
1 Read

Molecular remission and response patterns in patients with mutant- acute myeloid leukemia treated with enasidenib.

Blood 2018 Dec 3. Epub 2018 Dec 3.

Gustave Roussy, Departement d'hematologie et Departement d'innovation therapeutique, Villejuif, France.

Approximately 8-19% of patients with acute myeloid leukemia (AML) have isocitrate dehydrogenase-2 () mutations, which occur at active site arginine residues, R140 and R172. mutations produce an oncometabolite, 2-hydroxyglutarate (2-HG), that leads to DNA and histone hypermethylation and impaired hematopoietic differentiation. Enasidenib is an oral inhibitor of mutant-IDH2 proteins. Read More

View Article
December 2018
10.452 Impact Factor

Heterotopic chondroid tissue of the main bile duct mimicking Klatskin tumor: case report and review of the literature.

Clin J Gastroenterol 2018 Nov 29. Epub 2018 Nov 29.

Department of Surgery, School of Medicine, İzmir Katip Çelebi University, İzmir, Turkey.

Heterotopic tissue in the bile duct is a very rare condition. There are a few case reports of heterotopic tissue including gastric and pancreatic cells. However, we could not find any data regarding heterotopic chondroid tissue obstructing the common bile duct in the literature. Read More

View Article
November 2018

When results matter: reliable creatinine concentrations in hyperbilirubinemia patients.

Clin Chem Lab Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background Failure to report a creatinine concentration, especially in icteric patients who are eligible for a liver transplant, can result in a life-threatening situation. We assessed the influence of bilirubin interference on several creatinine assays and investigated ways to circumvent icteric interference without interfering with our normal automated sample logistics. Methods Using icteric patient sera (total bilirubin >255 μmol/L) we determined creatinine concentrations using an enzymatic and Jaffé assay (Roche Diagnostics) in both normal (i. Read More

View Article
November 2018

Kernicterus with abnormal high-signal changes bilaterally in the globus pallidus: A case report.

Ir Med J 2018 Apr 19;111(4):739. Epub 2018 Apr 19.

Department of Neuroradiology, Beaumont Hospital, Dublin 9, Ireland

Kernicterus is a relatively rare consequence of hyperbilirubinemia. There is an important role for MRI imaging for this entity in the appropriate clinical context as there are distinct signal changes in the globus pallidus. A case report and image findings are presented Read More

View Article

Safety of delayed umbilical cord clamping in preterm neonates of less than 34 weeks of gestation: a randomized controlled trial.

Obstet Gynecol Sci 2018 Nov 29;61(6):655-661. Epub 2018 Oct 29.

Department of Obstetrics and Gynecology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.

Objective: There is concern regarding the safety of delayed cord clamping (DCC) in babies born at less than 34 weeks' gestation. Therefore, the primary objective of this study was to compare the rates of hyperbilirubinemia and polycythemia during initial 7 days in infants born at less than 34 weeks' gestation and randomized to receive DCC by 120 seconds or early cord clamping (ECC) within less than 30 seconds.

Methods: One hundred pregnant women were randomly subjected to DCC or ECC at the time of birth in a tertiary referral hospital setting. Read More

View Article
November 2018

Unusual Case of an Infant with Urinary Tract Infection Presenting as Cholestatic Jaundice.

Case Rep Nephrol 2018 24;2018:9074245. Epub 2018 Oct 24.

Pediatric Nephrology Center of Excellence, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Neonatal jaundice is considered one of the most common reasons for admission to the pediatric medical ward. We report a case of a 1-month-old infant who presented with jaundice but no fever or any other signs of systemic illnesses. Laboratory test results revealed high direct hyperbilirubinemia, and urine culture showed a urinary tract infection with as the causative agent. Read More

View Article
October 2018
1 Read

Gestational Diabetes: Glycemic Control in the Last Two Weeks Before Delivery Contributes to Newborn Insulinemia.

J Obstet Gynaecol Can 2018 Nov;40(11):1445-1452

Department of Obstetrics & Gynecology, College of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Introduction: Fetal hyperinsulinemia in gestational diabetes mellitus (GDM) not only is important during intrauterine life, a time when it can result in macrosomia, but also at delivery, since it can result in neonatal hypoglycemia and hyperbilirubinemia. The question is, how long before delivery does maternal glycemic control contribute to newborn insulinemia in GDM?

Methods: In 72 women with GDM, we calculated Spearman's rank (r) correlations between umbilical cord blood C-peptide at birth (a biomarker of insulin secretion), and both maternal glycosylated hemoglobin (HbA1c) and mean blood glucose (MBG) recorded in the last two visits prior to delivery. Iterative correlations were done between umbilical cord blood C-peptide at birth, and maternal glucose control, at 0, 1, 2, 3, 4, and 5 weeks before delivery. Read More

View Article
November 2018
1 Read

Transcutaneous bilirubin nomogram for evaluating the risk of hyperbilirubinemia in Iranian healthy newborns.

World J Pediatr 2018 Nov 21. Epub 2018 Nov 21.

Department of Midwifery, Students Research Committee, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Hyperbilirubinemia, which is mostly benign, is one of the most common problems in neonates. This study was conducted to draw a skin bilirubin nomogram for evaluating the risk of hyperbilirubinemia requiring treatment.

Methods: This cross-sectional study recruited 1066 healthy infants. Read More

View Article
November 2018
1 Read

Changes in preoperative endoscopic and percutaneous bile drainage in patients with periampullary cancer undergoing pancreaticoduodenectomy in Ontario: effect on clinical practice of a randomized trial.

Curr Oncol 2018 Oct 31;25(5):e430-e435. Epub 2018 Oct 31.

Division of General Surgery, Department of Surgery, University of Toronto, Toronto, ON.

Background: In 2010, a multicentre randomized controlled trial reported increased postoperative complications in pancreaticoduodenectomy (pde) patients undergoing preoperative biliary decompression (pbd). We evaluated the effect of that publication on rates of pbd at the population level.

Methods: This retrospective observational cohort study identified patients undergoing pde for malignancy, 2005-2013, linking them with administrative health care databases covering medical services for a population of 13. Read More

View Article
October 2018

Effect of phototherapy on oxidant/antioxidant status: A randomized controlled trial.

Free Radic Res 2018 Nov 20:1-291. Epub 2018 Nov 20.

b Pediatrics Department , Military Medical Academy , Cairo , Egypt.

In order to evaluate the effect of different types of phototherapy on oxidant/antioxidant status in hyperbilirubinemic neonates, an interventional randomized control trial was conducted on 120 neonates ≥ 35 weeks' gestational age with indirect hyperbilirubinemia reaching phototherapy level. This study is registered with ClinicalTrials.gov as NCT03074292 . Read More

View Article
November 2018
1 Read

Free Newborn Care Services: A New Initiative in Nepal.

J Nepal Health Res Counc 2018 Oct 30;16(3):340-344. Epub 2018 Oct 30.

Child Health Division, Department of Health Services, Ministry of Health and Population, Government of Nepal, Kathmandu, Nepal.

Background: Nepal has made a significant progress in reducing child mortality. However, the annual rate of reduction in neonatal mortality is not satisfactory. As safeguarded by constitution of Nepal and to address neonatal mortality due to poverty and inequity, government has introduced free newborn care (FNC) package. Read More

View Article
October 2018
6 Reads

The Late Preterm: A Population at Risk.

Crit Care Nurs Clin North Am 2018 Dec 16;30(4):431-443. Epub 2018 Oct 16.

Department of Pediatrics, Community Neonatal Associates, Holy Cross Hospital, 1500 Forest Glen Road, Silver Spring, MD 20910, USA.

Late preterm infants (LPIs) are born between 34 0/7 and 36 6/7 weeks' gestation and account for 72% of all preterm births in the United States. Born as much as 6 weeks early, the LPI misses the critical growth and development specific to the third trimester. The loss of this critical period leaves the LPI physiologically and metabolically immature and prone to various morbidities. Read More

View Article
December 2018
2 Reads

On the Effective Differentiation and Monitoring of Variable Degrees of Hyperbilirubinemia Severity Through Noninvasive Screening Protocols.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:4981-4986

The presence of abnormal amounts of bilirubin in the blood stream and skin, usually referred to as hyperbilirubinemia, is associated with a wide range of pathologies that can pose considerable risks for human health. The early and effective screening of the severity degrees of this medical condition can play an important role on the selection of the appropriate treatment for the associated pathologies. This, in turn, can minimize the need for more aggressive and costly therapeutic interventions which can themselves pose considerable risks for morbidity and mortality. Read More

View Article
July 2018
1 Read

Comparison between autologous and homologous blood transfusions in liver resection for biliary tract cancer: a propensity score matching analysis.

J Hepatobiliary Pancreat Sci 2018 Nov 14. Epub 2018 Nov 14.

Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Background: It remains unclear whether preoperative blood donation is truly beneficial in liver surgery. The aim of this study was to compare surgical outcomes between patients receiving autologous and homologous transfusions during liver resection for biliary tract cancer (BTC).

Methods: Patients who underwent hepatectomy for BTC were retrospectively reviewed (2006-2017). Read More

View Article
November 2018
4 Reads

(TA) Promoter Genotype: Diagnostic and Population Pharmacogenetic Marker in Serbia.

Balkan J Med Genet 2018 Jun 29;21(1):59-68. Epub 2018 Oct 29.

Laboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.

The UGT1A1 enzyme is involved in the metabolism of bilirubin and numerous medications. Unconjugated hyperbilirubinemia, commonly presented as Gilbert syndrome (GS), is a result of decreased activity of the UGT1A1 enzyme, variable number of TA repeats in the promoter of the gene affects enzyme activity. Seven and eight TA repeats cause a decrease of UGT1A1 activity and risk GS alleles, while six TA repeats contribute to normal UGT1A1 activity and non-risk GS allele. Read More

View Article
June 2018
1 Read

Neonatal Cholestasis: A Primer of Selected Etiologies.

Authors:
Ranjani Ananth

Pediatr Ann 2018 Nov;47(11):e433-e439

Cholestasis refers to impairment in formation or excretion of bile. This can be due to defects in intrahepatic production of bile, defects in the transmembrane transport of bile, or mechanical obstruction to bile flow. Clinical features of cholestasis reflect the retention of components of bile (bilirubin, bile acids, cholesterol) in the body. Read More

View Article
November 2018
7 Reads

An unexpectedly prolonged severe hyperbilirubinemia in a patient with pre-existing hepatitis A: a role of genetic predisposition?

Clin Chem Lab Med 2018 Nov 13. Epub 2018 Nov 13.

Dipartimento di Scienze Biomediche e Cliniche 'Luigi Sacco', Università degli Studi, Milan, Italy.

View Article
November 2018
4 Reads

A systematic review on the impact of gestational Lyme disease in humans on the fetus and newborn.

PLoS One 2018 12;13(11):e0207067. Epub 2018 Nov 12.

National Microbiology Laboratory, Public Health Agency of Canada, Saint-Hyacinthe, Quebec, Canada.

Lyme disease (LD), caused by bacteria of the Borrelia burgdorferi sensu lato species complex, is the most common vector-borne disease in North America and Europe. A systematic review (SR) was conducted to summarize the global literature on adverse birth outcomes associated with gestational LD in humans. The SR followed an a priori protocol of pretested screening, risk of bias, and data extraction forms. Read More

View Article
November 2018
3 Reads

Direct hyperbilirubinemia in newborns with gastroschisis.

Pediatr Surg Int 2018 Nov 10. Epub 2018 Nov 10.

Department of Pediatric Surgery, John R. Oishei Children's Hospital, 1001 Main Street, Buffalo, NY, 14203, USA.

Background: Patients with gastroschisis and prolonged total (or partial) parenteral nutrition (PN) commonly develop direct hyperbilirubinemia (DH).

Objective: To quantify the prevalence and severity of DH in newborns with gastroschisis and characterize the diagnostic work-up for DH in this patient population.

Design/methods: Retrospective chart review of patients born with gastroschisis between 2005 and 2015 for the first 6 months of life. Read More

View Article
November 2018
4 Reads

Pamidronate decreases bilirubin-impaired cell death and improves dentinogenic dysfunction of stem cells from human deciduous teeth.

Stem Cell Res Ther 2018 Nov 8;9(1):303. Epub 2018 Nov 8.

Department of Molecular Cell Biology and Oral Anatomy, Division of Oral Biological Sciences, Kyushu University Graduate School of Dental Science, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Hyperbilirubinemia that occurs in pediatric liver diseases such as biliary atresia can result in the development of not only jaundice in the brain, eyes, and skin, but also tooth abnormalities including green pigmentation and dentin hypoplasia in the developing teeth. However, hyperbilirubinemia-induced tooth impairments remain after liver transplantation. No effective dental management to prevent hyperbilirubinemia-induced tooth impairments has been established. Read More

View Article
November 2018
9 Reads

Characteristics and outcome of newborn admitted with acute bilirubin encephalopathy to a tertiary neonatal intensive care unit.

World J Pediatr 2018 Nov 7. Epub 2018 Nov 7.

Ministry of Health, Cairo, Egypt.

Background: Acute bilirubin encephalopathy (ABE) still represents a significant cause of morbidity and mortality throughout the world, especially in developing countries. We aimed to determine the prevalence of ABE based on the Johnson bilirubin-induced neurologic dysfunction (BIND) score and to describe the discharge outcomes.

Methods: We prospectively studied all newborns ≥ 35 weeks with ABE by evaluating signs of mental sensorium, muscle tone, and cry patterns over 1 year. Read More

View Article
November 2018

A Prospective Study on the Diagnostic Value of Hyperbilirubinemia as a Predictive Factor for Appendicular Perforation in Acute Appendicitis.

Cureus 2018 Aug 27;10(8):e3214. Epub 2018 Aug 27.

General Surgery, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, IND.

Background Appendicitis is one of the most common surgical emergency in general surgical practices. Early and prompt diagnosis is necessary to avoid life-threatening complications associated with it. The diagnosis is mainly clinically aided by imaging techniques. Read More

View Article

Clinical and Laboratory Features Associated with Acute Kidney Injury in Severe Malaria.

Indian J Crit Care Med 2018 Oct;22(10):718-722

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Critically ill severe malaria constitutes one of the major hospital admissions in Indian setting. Clinical studies identifying the factors associated with acute kidney injury (AKI) in malaria are lacking. This study aimed to identify these factors. Read More

View Article
October 2018
2 Reads

Hyperbilirubinemia and Follow-up Auditory Brainstem Responses in Preterm Infants.

Clin Exp Otorhinolaryngol 2018 Nov 9. Epub 2018 Nov 9.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.

Objectives: Neonatal hyperbilirubinemia is considered one of the most common causative factors of hearing loss. Preterm infants are more vulnerable to neuronal damage caused by hyperbilirubinemia. This study aimed to evaluate the effect of hyperbilirubinemia on hearing threshold and auditory pathway in preterm infants by serial auditory brainstem response (ABR). Read More

View Article
November 2018
10 Reads

Risk for hemorrhage after pancreatoduodenectomy with venous resection.

Langenbecks Arch Surg 2018 Nov 5. Epub 2018 Nov 5.

Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Rikshospitalet, Nydalen, 0424, Oslo, Norway.

Purpose: No consensus exists on the optimal anticoagulation therapy after pancreatoduodenectomy with venous resection (PDVR). The aim of the study was to analyze perioperative outcomes of patients receiving low- vs high-dose anticoagulation therapy and to identify risk factors for postpancreatectomy hemorrhage in patients undergoing PDVR.

Methods: Retrospective study of patients undergoing PDVR at a tertiary referral center between January 2006 and April 2017. Read More

View Article
November 2018
4 Reads
2.160 Impact Factor

Bile Cast Nephropathy: A Pathologic Finding with Manifold Causes Displayed in an Adult with Alcoholic Steatohepatitis and in a Child with Wilson's Disease.

Case Rep Nephrol Dial 2018 Sep-Dec;8(3):207-215. Epub 2018 Sep 27.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Bile cast nephropathy (BCN) is seen in patients who have acute kidney injury and severe hyperbilirubinemia due to a wide range of hepatobiliary system diseases. Findings seen by renal biopsy include acute tubular injury with necrotic and sloughed epithelial cells, yellow-green pigment within tubular epithelial cells, and pigmented granular casts. Hall's special stain for bile turns these casts green. Read More

View Article
September 2018
6 Reads

Developmental influence of unconjugated hyperbilirubinemia and neurobehavioral disorders.

Pediatr Res 2018 Oct 23. Epub 2018 Oct 23.

Communication Sciences and Disorders, James Madison University, Harrisonburg, VA, USA.

Bilirubin-induced brain injury in the neonatal period has detrimental effects on neurodevelopment that persist into childhood and adulthood, contributing to childhood developmental disorders. Unconjugated bilirubin is a potent antioxidant that may be useful for protecting against oxidative injuries, but it becomes a potent neurotoxin once it crosses the blood brain barrier. Because bilirubin toxicity involves a myriad of pathological mechanisms, can damage most types of brain cells, and affects brain circuits or loops that influence cognition, learning, behavior, sensory, and language, the clinical effects of bilirubin-induced neurotoxicity are likely to be manifold. Read More

View Article
October 2018
5 Reads

Paper-based potentiometric sensing of free bilirubin in blood serum.

Biosens Bioelectron 2018 Oct 27;126:115-121. Epub 2018 Oct 27.

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, MA 02138, United States; Kavli Institute for Bionano Inspired Science and Technology, School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, MA 02138, United States; Wyss Institute for Biologically Inspired Engineering, Harvard University, 60 Oxford Street, MA 02138, United States. Electronic address:

Bilirubin is predominantly formed in the liver as a result of breakdown of hemoglobin. Knowing the concentration of bilirubin in serum is important in evaluating the health of the liver, and for the diagnosis of hyperbilirubinemia (a condition that afflicts approximately 60% of full-term and 80% of pre-term newborns). This paper describes the design and fabrication of a potentiometric sensor for the determination of free bilirubin in serum. Read More

View Article
October 2018
3 Reads

[Clinical and laboratory characteristics and genetic diagnosis of Kabuki syndrome].

Zhonghua Er Ke Za Zhi 2018 Nov;56(11):846-849

Department of Neurology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.

To investigate the clinical features, laboratory characteristics and genetic diagnosis of Kabuki syndrome (KS). Between September 2014 and September 2016, seven children with clinically diagnosed KS from the neurology department, Beijing Children Hospital, Capital Medical University were included in this study. Three of them were male and 4 were female aged from 19 days to 6 years and 4 months with a median age of 3 years and 1 month. Read More

View Article
November 2018
4 Reads

Obstructive jaundice due to a blood clot after ERCP: a case report and review of the literature.

BMC Gastroenterol 2018 Nov 3;18(1):163. Epub 2018 Nov 3.

Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China.

Background: Endoscopic retrograde cholangiopancreatography (ERCP) is one of the most frequently performed procedures for the treatment of biliary-pancreatic diseases. The most frequent complications of ERCP include pancreatitis, haemorrhage, perforation and cholangitis. While post-ERCP biliary bleeding leading to biliary obstruction is rare. Read More

View Article
November 2018
3 Reads

Blood schizonticidal activity and safety of tafenoquine when administered as chemoprophylaxis to healthy, non-immune participants followed by blood stage Plasmodium falciparum challenge: A randomized, double-blinded, placebo-controlled Phase 1b study.

Clin Infect Dis 2018 Nov 1. Epub 2018 Nov 1.

60P Australia Pty Ltd, Sydney, Australia.

Background: Tafenoquine was recently approved as a chemoprophylaxis for malaria (all species). Its activity against liver and blood stages has been separately characterized in animals but not in humans.

Methods: In this randomized, double-blinded, placebo-controlled study, 16 malaria naïve, G6PD-normal participants aged 20-42 years received tafenoquine chemoprophylaxis prior to challenge with blood stage P. Read More

View Article
November 2018

Efficacy and safety of BRAF inhibitors and anti-CTLA4 antibody in melanoma patients-real-world data.

Eur J Clin Pharmacol 2018 Nov 1. Epub 2018 Nov 1.

Department of Clinical Pharmacy and Pharmaceutical Care, Faculty of Pharmacy, Medical University of Warsaw, Banacha St. 1, 02-097, Warsaw, Poland.

Purpose: In the management of melanoma, BRAF inhibitors yield fast disease control; however, the duration of response does not last very long. Ipilimumab-an anti-CTLA4 antibody on the other hand-provides longer-lasting results of treatment but achieves less favorable responses. The aim of this study was to assess the efficacy and safety of novel drugs for advanced melanoma in daily routine practice. Read More

View Article
November 2018

A Novel Pathogenic Variant in a Sudanese Child with Type I Crigler-Najjar Syndrome.

Drug Metab Dispos 2018 Nov 1. Epub 2018 Nov 1.

Yale University School of Medicine;

Uridine diphosphate glucuronosyltransferases (UGTs) are key enzymes responsible for the body's ability to process of a variety of endogenous and exogenous compounds. Significant gains in the understanding of UGT function have come from the analysis of variants seen in patients. We cared for a Sudanese child who presented with clinical features of Type I Crigler-Najjar syndrome (CN-I), namely severe unconjugated hyperbilirubinemia leading to liver transplantation. Read More

View Article
November 2018
3 Reads

Elevated blood carboxyhemoglobin levels as an early predictor of phototherapy requirement in moderate and late preterm infants.

J Matern Fetal Neonatal Med 2018 Oct 29:1-131. Epub 2018 Oct 29.

a Department of Pediatrics , Bursa Yüksek Ihtisas Teaching Hospital , Division of Neonatology , Bursa , Turkey.

Objective: Preterm infants are prone to increased bilirubin burden and display adverse outcomes if left unmonitored; therefore, predicting an increased bilirubin production is of paramount importance.

Methods: We aimed to evaluate carboxyhemoglobin (COHb) levels in moderate (GA: 32-33) and late preterm (GA: 34-36) infants to assess whether this molecule could be used as an early predictor of phototherapy requirement. A total of 221 infants were enrolled in the study. Read More

View Article
October 2018

Newborn Metabolic Profile Associated with Hyperbilirubinemia With and Without Kernicterus.

Clin Transl Sci 2018 Oct 28. Epub 2018 Oct 28.

Department of Epidemiology and Biostatistics and the California Preterm Birth Initiative, University of California San Francisco, San Francisco, California, USA.

Our objective was to assess the relationship between hyperbilirubinemia with and without kernicterus and metabolic profile at newborn screening. Included were 1,693,658 infants divided into a training or testing subset in a ratio of 3:1. Forty-two metabolites were analyzed using logistic regression (odds ratios (ORs), area under the receiver operating characteristic curve (AUC), 95% confidence intervals (CIs)). Read More

View Article
October 2018

Clinical presentation of autoimmune hepatitis in Pakistani children.

Pan Afr Med J 2018 12;30:117. Epub 2018 Jun 12.

Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistani.

Introduction: Autoimmune hepatitis (AIH) is one of the most common disorder resulting in end stage liver disease (ESLD) among children. Scarce data is available in this regard from Pakistan. In this study we have analyzed clinical and biochemical parameters of children suffering from this disorder. Read More

View Article
November 2018
4 Reads

Resection for hepatocellular cancer: overpassing old barriers.

Transl Gastroenterol Hepatol 2018 17;3:64. Epub 2018 Sep 17.

Department of Surgery, Oncology and Gastroenterology, Padua University, Padua, Italy.

Several recent studies have shown that the selection limits commonly used for patients with hepatocellular cancer (HCC) potentially requiring a liver resection (LR) are too restrictive. The present review aims at investigating the studies showing that LR is no longer a treatment suitable only for highly selected patients, but also for patients selectively presenting one-to-more negative factors. Several specific variables have been investigated, none of them showing to be an absolute contraindication for LR: age; single vs. Read More

View Article
September 2018
5 Reads

Safety and efficacy of a combination of pethidine and levallorphan for pain relief during labor: An observational study.

J Obstet Gynaecol Res 2018 Oct 25. Epub 2018 Oct 25.

Department of Obstetrics/Gynecology, Amagasaki Medical Coop Hospital, Amagasaki, Japan.

Aim: To evaluate the safety, effect on breastfeeding and efficacy of a combination of pethidine and levallorphan (Pethilorfan) for pain relief during labor.

Methods: We compared maternal or neonatal morbidities, suckling difficulties in newborns and breastfeeding rates between 177 women who received 50-200 mg (as pethidine) of Pethilorfan during labor (Pethilorfan group) and 354 women who delivered their infants without analgesic drugs immediately before or after each woman in the Pethilorfan group (control group) from January 1, 2005 to December 31, 2016. We performed univariate and multivariate analyses for comparison between the two groups. Read More

View Article
October 2018

Isolation of a novel glycyrrhizin metabolite as a causal candidate compound for pseudoaldosteronism.

Sci Rep 2018 Oct 22;8(1):15568. Epub 2018 Oct 22.

Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-Dori, Mizuho-ku, Nagoya, Japan.

Pseudoaldosteronism is a common adverse effect associated with traditional Japanese Kampo medicines. The pathogenesis is mainly caused by 3-monoglucuronyl glycyrrhetinic acid (3MGA), one of the metabolites of glycyrrhizin (GL) contained in licorice. We developed an anti-3MGA monoclonal antibody (MAb) and an ELISA system to easily detect 3MGA in the plasma and urine of the patients. Read More

View Article
October 2018

Dexamethasone for postoperative hyperbilirubinemia in patients after liver resection: An open-label, randomized controlled trial.

Surgery 2018 Oct 19. Epub 2018 Oct 19.

Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory for Carcinogenesis and Cancer Invasion, Chinese Ministry of Education; Shanghai, China. Electronic address:

Background: Although prophylactic glucocorticoids have been used before liver resection to minimize liver dysfunction, it is unknown whether treatment with glucocorticoids will accelerates recovery from hyperbilirubinemia after liver resection.

Methods: In this open-label, randomized, controlled trial, patients with hyperbilirubinemia (>2.5 × and ≤5 × the upper limit of normal) within 7 days after hepatic resection were assigned randomly to the dexamethasone or control groups. Read More

View Article
October 2018
4 Reads

Epidemiology of Hyperbilirubinemia in a Quaternary Pediatric Emergency Department over a Three-Year Period.

Pediatr Gastroenterol Hepatol Nutr 2018 Oct 10;21(4):297-305. Epub 2018 Oct 10.

Division of Gastroenterology, Texas Children's Hospital, Houston, TX, United States.

Purpose: There is a lack of scholarly reports on pediatric emergency department (PED) exposure to hyperbilirubinemia. We aimed to describe the epidemiology of hyperbilirubinemia in patients presenting to a PED over a three-year period.

Methods: This was a retrospective cohort study, completed at an urban quaternary academic PED. Read More

View Article
October 2018

Naphthalene Toxicity: Methemoglobinemia and Acute Intravascular Hemolysis.

Cureus 2018 Aug 15;10(8):e3147. Epub 2018 Aug 15.

Internal Medicine, University of Maryland Prince George's Hospital Center, Cheverly, USA.

Naphthalene poisoning is a rare form of toxicity that may occur after ingestion, inhalation, or dermal exposure to naphthalene-containing compounds such as mothballs. Clinically, patients present with acute onset of dark brown urine, watery diarrhea, and non-bloody bilious vomiting 48-96 hours after exposure. Vital sign abnormalities include fever, tachycardia, hypotension, and persistent pulse oximetry readings of 84%-85% despite oxygen supplementation. Read More

View Article
August 2018
3 Reads

Maternal risk factors for neonatal jaundice: a hospital-based cross-sectional study in Tehran.

Eur J Transl Myol 2018 Jul 10;28(3):7618. Epub 2018 Jul 10.

Department of Pediatrics, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Diagnosis and timely treatment of neonatal jaundice is critical to preventing its dangerous side effects. Knowing the predisposing factors of neonatal jaundice is still a serious debate, which can be effective in controlling jaundice and the primary problem. The aim of this study was to evaluate maternal risk factors that contribute to the Hyperbilirubinemia among newborns admitted to Imam Khomeini and Ziaeean hospitals during 2015. Read More

View Article
July 2018
4 Reads

Mutation analysis of the gene in Chinese patients with Dubin-Johnson syndrome.

Exp Ther Med 2018 Nov 3;16(5):4201-4206. Epub 2018 Sep 3.

Liver Research Center, Experimental Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.

Dubin-Johnson syndrome (DJS) is a rare, autosomal recessive disorder characterized by predominantly conjugated hyperbilirubinemia, caused by a mutation in the adenosine triphosphate-binding cassette subfamily C member 2 () gene coding the multidrug resistance-associated protein 2 (MRP2) protein. mutations have been identified in patients with DJS worldwide; however, the mutation pattern of in China is not well studied. In the present study, the mutation pattern of the gene in Chinese patients with DJS was investigated. Read More

View Article
November 2018
5 Reads
0.940 Impact Factor

Impact of prenatal exercise on neonatal and childhood outcomes: a systematic review and meta-analysis.

Br J Sports Med 2018 Nov;52(21):1386-1396

R Samuel McLaughlin Foundation - Exercise and Pregnancy Laboratory, School of Kinesiology, Faculty of Health Sciences, Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, Children's Health Research Institute, The University of Western Ontario, London, Ontario, Canada.

Objective: We aimed to identify the relationship between maternal prenatal exercise and birth complications, and neonatal and childhood morphometric, metabolic and developmental outcomes.

Design: Systematic review with random-effects meta-analysis and meta-regression.

Data Sources: Online databases were searched up to 6 January 2017. Read More

View Article
November 2018
1 Read