29,612 results match your criteria Hyperbilirubinemia Conjugated
Wellcome Open Res 2018 23;3:110. Epub 2018 Nov 23.
Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, 63110, Thailand.
Screening and monitoring serum bilirubin (SBR) in neonates is crucial to prevent neonatal hyperbilirubinemia (NH)-associated morbidity and mortality worldwide. A lack of resources is often a barrier for measuring SBR in developing countries. Reliable, cost-effective, easy to use point-of-care (POC) SBR tests are needed. Read More
Congenit Heart Dis 2018 Dec 11. Epub 2018 Dec 11.
Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Even though up to 60% of premature infants less than 28 weeks gestation develop persistent patent ductus arteriosus (PDA), there remains controversy regarding if, when, and how to close the PDA. Failure to close the PDA has been associated with significant morbidity but no cause-and-effect has been proven for short-term or long-term outcomes in modern times. Surgical closure has the advantage of eliminating the PDA, but short-term complications and long-term adverse outcomes are worrisome. Read More
Khirurgiia (Mosk) 2018 (10):44-50
South Ural State Medical University of Healthcare Ministry of the Russian Federation, Chelyabinsk, Russia.
Aim: To determine optimal terms of biliary decompression and bile reinfusion into gastrointestinal tract in patients with malignant obstructive jaundice.
Material And Methods: 179 medical records of patients with obstructive jaundice were analyzed to identify risk factors of postoperative complications. Prospective research included bile examination in 34 patients with malignant obstructive jaundice. Read More
J Hepatol 2018 Dec 5. Epub 2018 Dec 5.
Keimyung University Dongsan Medical Center, South Korea.
Background/aims: To compare clinical outcomes of sorafenib combined with concurrent conventional transarterial chemoembolization (cTACE) (SOR+T) with those of sorafenib alone in patients with advanced hepatocellular carcinoma (HCC) in an investigator-initiated, multicenter, randomized, phase III trial.
Methods: After randomization, all eligible patients received sorafenib with (Arm C, n=170) or without (Arm S, n=169) cTACE within 3 days and cTACE within 7-21 days, with repeated cTACE on demand (Arm C). The primary endpoint was overall survival (OS). Read More
J Vasc Interv Radiol 2018 Dec 6. Epub 2018 Dec 6.
Department of Radiology, Kyungpook National University School of Medicine, Daegu, Korea.
Purpose: To retrospectively investigate the impact of hyperbilirubinemia on future liver remnant (FLR) volume after percutaneous transhepatic portal vein embolization (PVE) and incidence of post-hepatectomy liver failure in primary biliary malignancy.
Materials And Methods: Eighty-seven patients (62 men, overall mean age 66.9 y) who underwent PVE, using Gelfoam and coils before major hepatectomy between January 2004 and June 2016, were included in this study and divided into a hyperbilirubinemia (serum total bilirubin level at PVE 5. Read More
J Surg Res 2019 Feb 27;234:13-19. Epub 2018 Sep 27.
Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, Missouri. Electronic address:
Background: Short bowel syndrome (SBS) results from extensive bowel resection. Patients with SBS require total parenteral nutrition (TPN) for survival. Understanding mechanisms contributing to TPN-associated liver injury and gut atrophy are critical in developing SBS therapies. Read More
Pediatr Res 2018 Dec 5. Epub 2018 Dec 5.
Keck School of Medicine of University of Southern California, Division of Neonatology, Department of Pediatrics, LAC+USC Medical Center, Los Angeles, CA, USA.
Neonatal hyperbilirubinemia is one of the most frequent diagnoses made in neonates. A high level of unconjugated bilirubin that is unbound to albumin is neurotoxic when the level exceeds age-specific thresholds or at lower levels in neonates with neurotoxic risk factors. Lower range of unbound bilirubin results in apoptosis, while moderate-to-high levels result in neuronal necrosis. Read More
Radiol Case Rep 2019 Feb 27;14(2):269-272. Epub 2018 Nov 27.
Department of Diagnostic and Interventional Radiology, Istanbul Training and Research Hospital, Istanbul, 34098, Turkey.
Bilhemia is very rare and serious complication of percutaneous transhepatic biliary drainage (PBD). Bile leakage occurs into the bloodstream through a fistula between the biliary tree and the hepatic venous system. We report a case of a 45-year-old woman with bilhemia complicated by PBD. Read More
Int J Environ Res Public Health 2018 Dec 2;15(12). Epub 2018 Dec 2.
Department of Epidemiology and Management, Pomeranian Medical University, 71-210 Szczecin, Poland.
Despite a number of studies on the risk factors of developmental delay (DD) in children conducted in developed countries, Polish data are scarce, which hinder an early diagnosis and initiation of prevention/control measures. Objective: To assess selected risk factors of DD in infants. A case-control survey was conducted in 2017⁻2018 on 50 infants (≤1 year old) with DD and 104 healthy controls from three outpatient clinics in Szczecin, Poland. Read More
Blood 2018 Dec 3. Epub 2018 Dec 3.
Gustave Roussy, Departement d'hematologie et Departement d'innovation therapeutique, Villejuif, France.
Approximately 8-19% of patients with acute myeloid leukemia (AML) have isocitrate dehydrogenase-2 () mutations, which occur at active site arginine residues, R140 and R172. mutations produce an oncometabolite, 2-hydroxyglutarate (2-HG), that leads to DNA and histone hypermethylation and impaired hematopoietic differentiation. Enasidenib is an oral inhibitor of mutant-IDH2 proteins. Read More
Clin J Gastroenterol 2018 Nov 29. Epub 2018 Nov 29.
Department of Surgery, School of Medicine, İzmir Katip Çelebi University, İzmir, Turkey.
Heterotopic tissue in the bile duct is a very rare condition. There are a few case reports of heterotopic tissue including gastric and pancreatic cells. However, we could not find any data regarding heterotopic chondroid tissue obstructing the common bile duct in the literature. Read More
Clin Chem Lab Med 2018 Nov 29. Epub 2018 Nov 29.
Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Background Failure to report a creatinine concentration, especially in icteric patients who are eligible for a liver transplant, can result in a life-threatening situation. We assessed the influence of bilirubin interference on several creatinine assays and investigated ways to circumvent icteric interference without interfering with our normal automated sample logistics. Methods Using icteric patient sera (total bilirubin >255 μmol/L) we determined creatinine concentrations using an enzymatic and Jaffé assay (Roche Diagnostics) in both normal (i. Read More
Ir Med J 2018 Apr 19;111(4):739. Epub 2018 Apr 19.
Department of Neuroradiology, Beaumont Hospital, Dublin 9, Ireland
Kernicterus is a relatively rare consequence of hyperbilirubinemia. There is an important role for MRI imaging for this entity in the appropriate clinical context as there are distinct signal changes in the globus pallidus. A case report and image findings are presented Read More
Obstet Gynecol Sci 2018 Nov 29;61(6):655-661. Epub 2018 Oct 29.
Department of Obstetrics and Gynecology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Objective: There is concern regarding the safety of delayed cord clamping (DCC) in babies born at less than 34 weeks' gestation. Therefore, the primary objective of this study was to compare the rates of hyperbilirubinemia and polycythemia during initial 7 days in infants born at less than 34 weeks' gestation and randomized to receive DCC by 120 seconds or early cord clamping (ECC) within less than 30 seconds.
Methods: One hundred pregnant women were randomly subjected to DCC or ECC at the time of birth in a tertiary referral hospital setting. Read More
Case Rep Nephrol 2018 24;2018:9074245. Epub 2018 Oct 24.
Pediatric Nephrology Center of Excellence, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Neonatal jaundice is considered one of the most common reasons for admission to the pediatric medical ward. We report a case of a 1-month-old infant who presented with jaundice but no fever or any other signs of systemic illnesses. Laboratory test results revealed high direct hyperbilirubinemia, and urine culture showed a urinary tract infection with as the causative agent. Read More
J Obstet Gynaecol Can 2018 Nov;40(11):1445-1452
Department of Obstetrics & Gynecology, College of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Introduction: Fetal hyperinsulinemia in gestational diabetes mellitus (GDM) not only is important during intrauterine life, a time when it can result in macrosomia, but also at delivery, since it can result in neonatal hypoglycemia and hyperbilirubinemia. The question is, how long before delivery does maternal glycemic control contribute to newborn insulinemia in GDM?
Methods: In 72 women with GDM, we calculated Spearman's rank (r) correlations between umbilical cord blood C-peptide at birth (a biomarker of insulin secretion), and both maternal glycosylated hemoglobin (HbA1c) and mean blood glucose (MBG) recorded in the last two visits prior to delivery. Iterative correlations were done between umbilical cord blood C-peptide at birth, and maternal glucose control, at 0, 1, 2, 3, 4, and 5 weeks before delivery. Read More
World J Pediatr 2018 Nov 21. Epub 2018 Nov 21.
Department of Midwifery, Students Research Committee, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.
Background: Hyperbilirubinemia, which is mostly benign, is one of the most common problems in neonates. This study was conducted to draw a skin bilirubin nomogram for evaluating the risk of hyperbilirubinemia requiring treatment.
Methods: This cross-sectional study recruited 1066 healthy infants. Read More
Curr Oncol 2018 Oct 31;25(5):e430-e435. Epub 2018 Oct 31.
Division of General Surgery, Department of Surgery, University of Toronto, Toronto, ON.
Background: In 2010, a multicentre randomized controlled trial reported increased postoperative complications in pancreaticoduodenectomy (pde) patients undergoing preoperative biliary decompression (pbd). We evaluated the effect of that publication on rates of pbd at the population level.
Methods: This retrospective observational cohort study identified patients undergoing pde for malignancy, 2005-2013, linking them with administrative health care databases covering medical services for a population of 13. Read More
Free Radic Res 2018 Nov 20:1-291. Epub 2018 Nov 20.
b Pediatrics Department , Military Medical Academy , Cairo , Egypt.
In order to evaluate the effect of different types of phototherapy on oxidant/antioxidant status in hyperbilirubinemic neonates, an interventional randomized control trial was conducted on 120 neonates ≥ 35 weeks' gestational age with indirect hyperbilirubinemia reaching phototherapy level. This study is registered with ClinicalTrials.gov as NCT03074292 . Read More
J Nepal Health Res Counc 2018 Oct 30;16(3):340-344. Epub 2018 Oct 30.
Child Health Division, Department of Health Services, Ministry of Health and Population, Government of Nepal, Kathmandu, Nepal.
Background: Nepal has made a significant progress in reducing child mortality. However, the annual rate of reduction in neonatal mortality is not satisfactory. As safeguarded by constitution of Nepal and to address neonatal mortality due to poverty and inequity, government has introduced free newborn care (FNC) package. Read More
Crit Care Nurs Clin North Am 2018 Dec 16;30(4):431-443. Epub 2018 Oct 16.
Department of Pediatrics, Community Neonatal Associates, Holy Cross Hospital, 1500 Forest Glen Road, Silver Spring, MD 20910, USA.
Late preterm infants (LPIs) are born between 34 0/7 and 36 6/7 weeks' gestation and account for 72% of all preterm births in the United States. Born as much as 6 weeks early, the LPI misses the critical growth and development specific to the third trimester. The loss of this critical period leaves the LPI physiologically and metabolically immature and prone to various morbidities. Read More
Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:4981-4986
The presence of abnormal amounts of bilirubin in the blood stream and skin, usually referred to as hyperbilirubinemia, is associated with a wide range of pathologies that can pose considerable risks for human health. The early and effective screening of the severity degrees of this medical condition can play an important role on the selection of the appropriate treatment for the associated pathologies. This, in turn, can minimize the need for more aggressive and costly therapeutic interventions which can themselves pose considerable risks for morbidity and mortality. Read More
J Hepatobiliary Pancreat Sci 2018 Nov 14. Epub 2018 Nov 14.
Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Background: It remains unclear whether preoperative blood donation is truly beneficial in liver surgery. The aim of this study was to compare surgical outcomes between patients receiving autologous and homologous transfusions during liver resection for biliary tract cancer (BTC).
Methods: Patients who underwent hepatectomy for BTC were retrospectively reviewed (2006-2017). Read More
Balkan J Med Genet 2018 Jun 29;21(1):59-68. Epub 2018 Oct 29.
Laboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.
The UGT1A1 enzyme is involved in the metabolism of bilirubin and numerous medications. Unconjugated hyperbilirubinemia, commonly presented as Gilbert syndrome (GS), is a result of decreased activity of the UGT1A1 enzyme, variable number of TA repeats in the promoter of the gene affects enzyme activity. Seven and eight TA repeats cause a decrease of UGT1A1 activity and risk GS alleles, while six TA repeats contribute to normal UGT1A1 activity and non-risk GS allele. Read More
Pediatr Ann 2018 Nov;47(11):e433-e439
Cholestasis refers to impairment in formation or excretion of bile. This can be due to defects in intrahepatic production of bile, defects in the transmembrane transport of bile, or mechanical obstruction to bile flow. Clinical features of cholestasis reflect the retention of components of bile (bilirubin, bile acids, cholesterol) in the body. Read More
Clin Chem Lab Med 2018 Nov 13. Epub 2018 Nov 13.
Dipartimento di Scienze Biomediche e Cliniche 'Luigi Sacco', Università degli Studi, Milan, Italy.
PLoS One 2018 12;13(11):e0207067. Epub 2018 Nov 12.
National Microbiology Laboratory, Public Health Agency of Canada, Saint-Hyacinthe, Quebec, Canada.
Lyme disease (LD), caused by bacteria of the Borrelia burgdorferi sensu lato species complex, is the most common vector-borne disease in North America and Europe. A systematic review (SR) was conducted to summarize the global literature on adverse birth outcomes associated with gestational LD in humans. The SR followed an a priori protocol of pretested screening, risk of bias, and data extraction forms. Read More
Pediatr Surg Int 2018 Nov 10. Epub 2018 Nov 10.
Department of Pediatric Surgery, John R. Oishei Children's Hospital, 1001 Main Street, Buffalo, NY, 14203, USA.
Background: Patients with gastroschisis and prolonged total (or partial) parenteral nutrition (PN) commonly develop direct hyperbilirubinemia (DH).
Objective: To quantify the prevalence and severity of DH in newborns with gastroschisis and characterize the diagnostic work-up for DH in this patient population.
Design/methods: Retrospective chart review of patients born with gastroschisis between 2005 and 2015 for the first 6 months of life. Read More
Stem Cell Res Ther 2018 Nov 8;9(1):303. Epub 2018 Nov 8.
Department of Molecular Cell Biology and Oral Anatomy, Division of Oral Biological Sciences, Kyushu University Graduate School of Dental Science, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Background: Hyperbilirubinemia that occurs in pediatric liver diseases such as biliary atresia can result in the development of not only jaundice in the brain, eyes, and skin, but also tooth abnormalities including green pigmentation and dentin hypoplasia in the developing teeth. However, hyperbilirubinemia-induced tooth impairments remain after liver transplantation. No effective dental management to prevent hyperbilirubinemia-induced tooth impairments has been established. Read More
World J Pediatr 2018 Nov 7. Epub 2018 Nov 7.
Ministry of Health, Cairo, Egypt.
Background: Acute bilirubin encephalopathy (ABE) still represents a significant cause of morbidity and mortality throughout the world, especially in developing countries. We aimed to determine the prevalence of ABE based on the Johnson bilirubin-induced neurologic dysfunction (BIND) score and to describe the discharge outcomes.
Methods: We prospectively studied all newborns ≥ 35 weeks with ABE by evaluating signs of mental sensorium, muscle tone, and cry patterns over 1 year. Read More
Cureus 2018 Aug 27;10(8):e3214. Epub 2018 Aug 27.
General Surgery, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, IND.
Background Appendicitis is one of the most common surgical emergency in general surgical practices. Early and prompt diagnosis is necessary to avoid life-threatening complications associated with it. The diagnosis is mainly clinically aided by imaging techniques. Read More
Indian J Crit Care Med 2018 Oct;22(10):718-722
Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Introduction: Critically ill severe malaria constitutes one of the major hospital admissions in Indian setting. Clinical studies identifying the factors associated with acute kidney injury (AKI) in malaria are lacking. This study aimed to identify these factors. Read More
Clin Exp Otorhinolaryngol 2018 Nov 9. Epub 2018 Nov 9.
Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.
Objectives: Neonatal hyperbilirubinemia is considered one of the most common causative factors of hearing loss. Preterm infants are more vulnerable to neuronal damage caused by hyperbilirubinemia. This study aimed to evaluate the effect of hyperbilirubinemia on hearing threshold and auditory pathway in preterm infants by serial auditory brainstem response (ABR). Read More
Langenbecks Arch Surg 2018 Nov 5. Epub 2018 Nov 5.
Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Rikshospitalet, Nydalen, 0424, Oslo, Norway.
Purpose: No consensus exists on the optimal anticoagulation therapy after pancreatoduodenectomy with venous resection (PDVR). The aim of the study was to analyze perioperative outcomes of patients receiving low- vs high-dose anticoagulation therapy and to identify risk factors for postpancreatectomy hemorrhage in patients undergoing PDVR.
Methods: Retrospective study of patients undergoing PDVR at a tertiary referral center between January 2006 and April 2017. Read More
Case Rep Nephrol Dial 2018 Sep-Dec;8(3):207-215. Epub 2018 Sep 27.
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Bile cast nephropathy (BCN) is seen in patients who have acute kidney injury and severe hyperbilirubinemia due to a wide range of hepatobiliary system diseases. Findings seen by renal biopsy include acute tubular injury with necrotic and sloughed epithelial cells, yellow-green pigment within tubular epithelial cells, and pigmented granular casts. Hall's special stain for bile turns these casts green. Read More
Pediatr Res 2018 Oct 23. Epub 2018 Oct 23.
Communication Sciences and Disorders, James Madison University, Harrisonburg, VA, USA.
Bilirubin-induced brain injury in the neonatal period has detrimental effects on neurodevelopment that persist into childhood and adulthood, contributing to childhood developmental disorders. Unconjugated bilirubin is a potent antioxidant that may be useful for protecting against oxidative injuries, but it becomes a potent neurotoxin once it crosses the blood brain barrier. Because bilirubin toxicity involves a myriad of pathological mechanisms, can damage most types of brain cells, and affects brain circuits or loops that influence cognition, learning, behavior, sensory, and language, the clinical effects of bilirubin-induced neurotoxicity are likely to be manifold. Read More
Biosens Bioelectron 2018 Oct 27;126:115-121. Epub 2018 Oct 27.
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, MA 02138, United States; Kavli Institute for Bionano Inspired Science and Technology, School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, MA 02138, United States; Wyss Institute for Biologically Inspired Engineering, Harvard University, 60 Oxford Street, MA 02138, United States. Electronic address:
Bilirubin is predominantly formed in the liver as a result of breakdown of hemoglobin. Knowing the concentration of bilirubin in serum is important in evaluating the health of the liver, and for the diagnosis of hyperbilirubinemia (a condition that afflicts approximately 60% of full-term and 80% of pre-term newborns). This paper describes the design and fabrication of a potentiometric sensor for the determination of free bilirubin in serum. Read More
Zhonghua Er Ke Za Zhi 2018 Nov;56(11):846-849
Department of Neurology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
To investigate the clinical features, laboratory characteristics and genetic diagnosis of Kabuki syndrome (KS). Between September 2014 and September 2016, seven children with clinically diagnosed KS from the neurology department, Beijing Children Hospital, Capital Medical University were included in this study. Three of them were male and 4 were female aged from 19 days to 6 years and 4 months with a median age of 3 years and 1 month. Read More
BMC Gastroenterol 2018 Nov 3;18(1):163. Epub 2018 Nov 3.
Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Background: Endoscopic retrograde cholangiopancreatography (ERCP) is one of the most frequently performed procedures for the treatment of biliary-pancreatic diseases. The most frequent complications of ERCP include pancreatitis, haemorrhage, perforation and cholangitis. While post-ERCP biliary bleeding leading to biliary obstruction is rare. Read More
Clin Infect Dis 2018 Nov 1. Epub 2018 Nov 1.
60P Australia Pty Ltd, Sydney, Australia.
Background: Tafenoquine was recently approved as a chemoprophylaxis for malaria (all species). Its activity against liver and blood stages has been separately characterized in animals but not in humans.
Methods: In this randomized, double-blinded, placebo-controlled study, 16 malaria naïve, G6PD-normal participants aged 20-42 years received tafenoquine chemoprophylaxis prior to challenge with blood stage P. Read More
Eur J Clin Pharmacol 2018 Nov 1. Epub 2018 Nov 1.
Department of Clinical Pharmacy and Pharmaceutical Care, Faculty of Pharmacy, Medical University of Warsaw, Banacha St. 1, 02-097, Warsaw, Poland.
Purpose: In the management of melanoma, BRAF inhibitors yield fast disease control; however, the duration of response does not last very long. Ipilimumab-an anti-CTLA4 antibody on the other hand-provides longer-lasting results of treatment but achieves less favorable responses. The aim of this study was to assess the efficacy and safety of novel drugs for advanced melanoma in daily routine practice. Read More
Drug Metab Dispos 2019 Jan 1;47(1):45-48. Epub 2018 Nov 1.
Department of Pediatrics, Milton S. Hershey Penn State Medical Center, Hershey, Pennsylvania (W.E.); Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Helsinki, Finland (E.J., J.M., M.F.); Pediatric Genomics Discovery Program, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut (W.J., A.G.S., M.K., S.A.L.); Departments of Pathology and Cell Biology (A.C.I.) and Surgery (S.J.L.), Columbia University Medical Center, New York, New York; and Department of Pediatrics, University of Rochester Medical Center, Rochester, New York (A.C.)
Uridine diphosphate glucuronosyltransferases (UGTs) are key enzymes responsible for the body's ability to process a variety of endogenous and exogenous compounds. Significant gains in understanding UGT function have come from the analysis of variants seen in patients. We cared for a Sudanese child who showed clinical features of type 1 Crigler-Najjar syndrome (CN-1), namely severe unconjugated hyperbilirubinemia leading to liver transplantation. Read More
J Matern Fetal Neonatal Med 2018 Oct 29:1-131. Epub 2018 Oct 29.
a Department of Pediatrics , Bursa Yüksek Ihtisas Teaching Hospital , Division of Neonatology , Bursa , Turkey.
Objective: Preterm infants are prone to increased bilirubin burden and display adverse outcomes if left unmonitored; therefore, predicting an increased bilirubin production is of paramount importance.
Methods: We aimed to evaluate carboxyhemoglobin (COHb) levels in moderate (GA: 32-33) and late preterm (GA: 34-36) infants to assess whether this molecule could be used as an early predictor of phototherapy requirement. A total of 221 infants were enrolled in the study. Read More
Clin Transl Sci 2018 Oct 28. Epub 2018 Oct 28.
Department of Epidemiology and Biostatistics and the California Preterm Birth Initiative, University of California San Francisco, San Francisco, California, USA.
Our objective was to assess the relationship between hyperbilirubinemia with and without kernicterus and metabolic profile at newborn screening. Included were 1,693,658 infants divided into a training or testing subset in a ratio of 3:1. Forty-two metabolites were analyzed using logistic regression (odds ratios (ORs), area under the receiver operating characteristic curve (AUC), 95% confidence intervals (CIs)). Read More
Pan Afr Med J 2018 12;30:117. Epub 2018 Jun 12.
Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistani.
Introduction: Autoimmune hepatitis (AIH) is one of the most common disorder resulting in end stage liver disease (ESLD) among children. Scarce data is available in this regard from Pakistan. In this study we have analyzed clinical and biochemical parameters of children suffering from this disorder. Read More
Transl Gastroenterol Hepatol 2018 17;3:64. Epub 2018 Sep 17.
Department of Surgery, Oncology and Gastroenterology, Padua University, Padua, Italy.
Several recent studies have shown that the selection limits commonly used for patients with hepatocellular cancer (HCC) potentially requiring a liver resection (LR) are too restrictive. The present review aims at investigating the studies showing that LR is no longer a treatment suitable only for highly selected patients, but also for patients selectively presenting one-to-more negative factors. Several specific variables have been investigated, none of them showing to be an absolute contraindication for LR: age; single vs. Read More
J Obstet Gynaecol Res 2018 Oct 25. Epub 2018 Oct 25.
Department of Obstetrics/Gynecology, Amagasaki Medical Coop Hospital, Amagasaki, Japan.
Aim: To evaluate the safety, effect on breastfeeding and efficacy of a combination of pethidine and levallorphan (Pethilorfan) for pain relief during labor.
Methods: We compared maternal or neonatal morbidities, suckling difficulties in newborns and breastfeeding rates between 177 women who received 50-200 mg (as pethidine) of Pethilorfan during labor (Pethilorfan group) and 354 women who delivered their infants without analgesic drugs immediately before or after each woman in the Pethilorfan group (control group) from January 1, 2005 to December 31, 2016. We performed univariate and multivariate analyses for comparison between the two groups. Read More
Sci Rep 2018 Oct 22;8(1):15568. Epub 2018 Oct 22.
Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-Dori, Mizuho-ku, Nagoya, Japan.
Pseudoaldosteronism is a common adverse effect associated with traditional Japanese Kampo medicines. The pathogenesis is mainly caused by 3-monoglucuronyl glycyrrhetinic acid (3MGA), one of the metabolites of glycyrrhizin (GL) contained in licorice. We developed an anti-3MGA monoclonal antibody (MAb) and an ELISA system to easily detect 3MGA in the plasma and urine of the patients. Read More