Search Our Scientific Publications & Authors

Oncol Rep 2019 Mar 14. Epub 2019 Mar 14.

Department of Experimental and Clinical Neuropathology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02‑106 Warsaw, Poland.

Glioblastoma (GBM) is the most common primary brain tumor. Tumor hypoxia is a pivotal factor responsible for the progression of this malignant glioma, and its resistance to radiation and chemotherapy. Thus, improved tumor tissue oxygenation may promote greater sensitivity to anticancer treatment. Read More

Oxid Med Cell Longev 2019 6;2019:8472346. Epub 2019 Feb 6.

Department of Medical Biology and Biochemistry, Collegium Medicum of Nicolaus Copernicus University, Karłowicza 24, 85-092 Bydgoszcz, Poland.

The concentration of thiobarbituric acid reactive substances (TBARSs) in plasma and erythrocytes, the activity of selected antioxidant enzymes in erythrocytes: catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx), and the levels of hemoglobin (HGB) and haematocrit (HCT) were determined in 40 patients with sudden sensorineural hearing loss (SSNHL) subjected to 14 treatment sessions in a Haux Starmed 2200 hyperbaric chamber. Hyperbaric oxygen (HBO) therapy involved breathing 100% oxygen at 0.25 MPa. Read More

Expert Opin Drug Discov 2019 Mar 14:1-13. Epub 2019 Mar 14.

a Department of Medical Cell Biology , Uppsala University , Uppsala , Sweden.

Introduction: Chronic, nonhealing skin wounds claim >3% of the health-care budget in industrialized countries, and the incidence is rising. Currently, two parallel trends influence innovations within the field of wound healing: the need to reduce spread of antibiotic resistance and the emerging use of health economy and value-based models. Areas covered: This review focuses on the discovery of drug candidates and development of treatments aiming to enhance wound healing in the heterogeneous group of patients with nonhealing wounds. Read More

Oncol Lett 2019 Mar 31;17(3):3277-3282. Epub 2019 Jan 31.

Department of Neurosurgery (Ward 1), People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China.

Hyperbaric oxygenation (HBO) on postoperative rehabilitation of brain tumors and effects on tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were explored. A retrospective analysis of 132 patients with brain tumors treated in the People's Hospital of Rizhao from October 2014 to October 2017 was performed. There were 62 patients in the observation group and 70 patients in the control group. Read More

Exp Ther Med 2019 Mar 25;17(3):2366-2372. Epub 2019 Jan 25.

Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

The aim of the present study was to investigate the effect of nursing cooperation on the post-operative complication of pain following total knee arthroplasty (TKA) and to explore the effects of tetramethylpyrazine (TMP) application on post-TKA pain. A total of 26 patients who received TKA between June 2014 and March 2016 were enrolled in this study. Nursing cooperation was provided to the patients during the TKA surgery, and pain was evaluated based on the visual analog scale (VAS). Read More

Arh Hig Rada Toksikol 2018 Dec;69(4):350-353

Polyclinic Salus, Pula, Croatia.

We report a unique and well-documented case of a type II decompression sickness (DCS) with a latency interval of 70 hours. It may raise divers' awareness and help medical practitioners to keep suspect divers under close observation longer than before and identify and treat DCS accordingly. Read More

Ann Burns Fire Disasters 2018 Sep;31(3):168-173

Aircrew's Health, Research and Training Center, Eskişehir, Turkey.

Carbon monoxide poisoning (COP) is one of the most common types of potentially fatal poisoning throughout the world. Hyperbaric oxygen therapy (HBOT) is an effective and quick response modality that clears symptoms and prevents sequelae. HBOT should be administered within 4-6 hours after poisoning. Read More

Clin Endosc 2019 Mar 13. Epub 2019 Mar 13.

Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Air embolism is a rare complication of upper endoscopy and potentially causes life-threatening events. A 67-year-old man with a history of surgery of cardiac carcinoma and pancreatic neuroendocrine tumor underwent painless upper endoscopy because of tarry stools. During the procedure, air embolism developed, which caused decreased pulse oxygen saturation and delayed sedation recovery. Read More

World Neurosurg 2019 Mar 8. Epub 2019 Mar 8.

Department of Neurosurgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Background: Radiation therapy for malignant head and neck cancers includes risk for off-target effects to bony structures, posing a risk for osteoradionecrosis (ORN). Patients who develop ORN can also harbor concomitant osteomyelitis and reduced healing capacity, making for a particularly challenging entity to treat. Hyperbaric oxygen therapy (HBO) has been shown to be effective in the treatment of mandibular ORN in the otolaryngology literature, yet few reports exist detailing its utility when treating ORN of the craniocervical junction. Read More

Diving Hyperb Med 2019 Mar;49(1):61-63

Department of Hyperbaric Medicine, Sainte-Marguerite Hospital, APHM, Marseille, France.

Introduction: Portal venous gas from a diving injury is an infrequent finding and only a few cases are described. We report a case of severe decompression sickness (DCS) associated with a massive amount of gas in the portal and mesenteric veins.

Case Report: A 49-year-old man suffered from DCS after two deep dives on the same day. Read More

Khirurgiia (Mosk) 2019 (2):13-18

Topchubashov Research Center for Surgery, Azerbaijan Republic, Baku, Azebaijan.

Aim: To evaluate an efficacy of efferent therapy of great vessels injuries of extremities and acute limb ischemia.

Material And Methods: There were 197 patients (main group -107, control group - 90 patients) with great vessels injuries of extremities and acute limb ischemia. The patients of the main group underwent plasmapheresis, ultraviolet irradiation of blood (UVIB) and hyperbaric oxygen (HBO) therapy. Read More

J Oral Maxillofac Surg 2019 Feb 13. Epub 2019 Feb 13.

Head, Oral and Maxillofacial Surgery, Western Hospital, Footscray; Clinical Associate Professor, University of Melbourne, Melbourne, VIC, Australia. Electronic address:

Purpose: Implant-supported dental prostheses offer numerous benefits for patients after ablative procedures of the head and neck region, including restoration of function, improved self-esteem and body satisfaction, and overall quality of life. Increased experience is emerging with immediate placement of implants at the time of ablative surgery compared with the traditional delayed approach. The authors sought to identify variables affecting survival of osseointegrated dental implants in such patients and to assess the impact of timing of implant insertion (immediate vs delayed) on the time until final prosthesis insertion. Read More

J Periodontal Implant Sci 2019 Feb 11;49(1):2-13. Epub 2019 Feb 11.

Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Korea.

Purpose: The aim of this study was to conduct a histologic evaluation of irradiated calvarial defects in rats 4 weeks after applying fibroblast growth factor-2 (FGF-2) with hyaluronan or biphasic calcium phosphate (BCP) block in the presence or absence of adjunctive hyperbaric oxygen (HBO) therapy.

Methods: Twenty rats were divided into HBO and non-HBO (NHBO) groups, each of which was divided into FGF-2 and BCP-block subgroups according to the grafted material. Localized radiation with a single 12-Gy dose was applied to the calvaria of rats to simulate radiotherapy. Read More

Front Biosci (Landmark Ed) 2019 03 1;24:859-869. Epub 2019 Mar 1.

Hyperbaric oxygen therapy center, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Sichuan, 610072, China.

Cerebral ischemia reperfusion (I/R) injury is associated with a high incidence of neurological morbidity and mortality worldwide. Higenamine has anti-inflammatory, anti-oxidative and anti-apoptotic capacities and has been successfully used in myocardial and intestinal ischemia reperfusion. We hypothesized that higenamine might serve the same effects in cerebral I/R. Read More

Eplasty 2019 5;19:e2. Epub 2019 Feb 5.

University of Texas Southwestern Medical Center, Dallas, Tex.

There are very few studies reporting the techniques utilized in penile replantation. Of those in literature, many agree that the use of microvascular technique results in better outcomes. The most common complications are skin necrosis and venous congestion, which are even higher in replants without arterial supply. Read More

Anticancer Res 2019 Mar;39(3):1259-1266

Department of Women's and Children's Health, Pediatric Haemato-Oncology, University of Padua, Padua, Italy.

Background/aim: In the last few decades, treatment strategies for acute lymphoblastic leukemia (ALL) have been associated not only with improvement of prognosis, but also with an increasing rate of late complication as osteonecrosis (ON). Herein, the cumulative incidence, risk factors, new conservative therapeutic strategies as hyperbaric oxygen therapy (HBO), and outcome of symptomatic ON were studied in pediatric patients with ALL.

Patients And Methods: Between 2000 and 2017, 495 children and young adolescents with a diagnosis of ALL were evaluated. Read More

Am J Occup Ther 2019 Jan/Feb;73(1):7301205020p1-7301205020p12

Jeff D. Radel, PhD, is Associate Professor, Department of Occupational Therapy Education, School of Health Professions, University of Kansas Medical Center, Kansas City.

Postconcussion syndrome (PCS) affects physical, cognitive, and emotional functioning. Existing reviews of interventions to address PCS are limited to psychological and rehabilitation interventions and to child and adolescent populations. We conducted a systematic review integrating current evidence about interventions for adults with PCS. Read More

Ann Gastroenterol 2019 Mar-Apr;32(2):156-167. Epub 2018 Dec 20.

Department of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, Utah (Douglas G. Adler), USA.

Air embolism is rarely diagnosed and is often fatal. The diagnosis is often not made in a timely manner given the rapid and severe clinical deterioration that often develops, frequently leading to cardiac arrest. Many patients are only diagnosed post-mortem. Read More

BMJ Open 2019 Mar 4;9(3):e026662. Epub 2019 Mar 4.

Oral and Maxillofacial Surgery, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.

Introduction: Osteoradionecrosis (ORN) of the mandible is a painful and debilitating condition occurring after radiotherapy to the head and neck to treat cancer. For decades, hyperbaric oxygen (HBO) has formed the mainstay of the early management of ORN. Literature about the efficacy of HBO is contentious. Read More

Int J Low Extrem Wounds 2019 Mar 5:1534734619829939. Epub 2019 Mar 5.

1 Physical Medicine, Rheumatology and Rehabilitation Department, Tanta University Hospitals, Tanta, Egypt.

Recent systematic reviews and meta-analyses have produced conflicting results about the efficacy of hyperbaric oxygen therapy (HBOT) in improving the healing rate for chronic diabetic foot wounds. This study aimed to assess the efficacy of systemic HBOT in healing of chronic nonischemic diabetic foot ulcer. Thirty adult patients having Wagner's grade 2 or 3 chronic diabetic foot ulcers, in whom the response to 30 days of standard wound care was not favorable, were prospectively randomized to have either HBOT (20-40 sessions) plus conventional treatment (n = 15) or conventional treatment alone (n = 15). Read More

J Epilepsy Res 2018 Dec 31;8(2):100-104. Epub 2018 Dec 31.

Department of Neurology, Kosin University College of Medicine, Busan, Korea.

Carbon monoxide (CO) poisoning is one of the most serious medical emergencies causing life-threatening conditions, including cardiovascular and neurological sequelae. Acute CO poisoning can lead to myocardial ischemia, ventricular arrhythmia, syncope, seizures, and coma. Seizures and other neurological complications in the early stages of presentation are related to severe intoxication in CO poisoning. Read More

Genet Test Mol Biomarkers 2019 Mar 26;23(3):188-196. Epub 2019 Feb 26.

2 Department of Hyperbaric Oxygenation, Dongying People's Hospital, Dongying, China.

Aim: This study was conducted to determine if single nucleotide polymorphisms within the interleukin (IL)-13 (rs20541 locus), the S100B (rs9722 locus), and the toll-like receptor (TLR)-7 (rs179019 and rs3853839 loci) genes are associated with the clinical severity of disease caused by enterovirus 71 (EV71) in children suffering from hand, foot, and mouth disease (HFMD).

Materials And Methods: A total of 355 children, diagnosed with HFMD, were divided into two groups: severe (totaling 162 cases) and mild (totaling 193 cases). Three hundred healthy children were recruited as a control group. Read More

Pediatr Dermatol 2019 Feb 25. Epub 2019 Feb 25.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Hidradenitis suppurativa is a painful chronic inflammatory skin condition characterized by inflammatory nodules that can lead to sinus tracts and scarring. Numerous treatments have been reported, though none have reliable efficacy. Antiinflammatory agents, such as tumor necrosis factor-alpha inhibitors and interleukin inhibitors, have been used as medical therapy for refractory cases. Read More

Saudi J Kidney Dis Transpl 2019 Jan-Feb;30(1):215-220

Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, USA.

Calciphylaxis, also known as calcific uremic arteriolopathy, is a rare, life-threatening complication of end-stage renal disease. However, it may also occur in patients without renal failure, the nonuremic calciphylaxis. Most patients present with painful skin ulcers. Read More

Alcohol Alcohol 2019 Feb 25. Epub 2019 Feb 25.

Maccabi-Kahn Research Institute, Israel.

A 15-year-old girl diagnosed with FASD underwent 100 courses of hyperbasic oxygen therapy (HBOT). Prior to HBOT, single motion emission compute tomographic begin imaging (SPECT) revealed areas of hypo-perfusion bilaterally in the orbitofrontal region, temporal lobes and right dorsolateral-frontal, as well the medial aspect of the left cerebellum. Following two sets of HBOT treatments (60 plus 40), over 6 months, there was improvement in perfusion to the left cerebellum as well as the right frontal lobe. Read More

Adv Skin Wound Care 2019 Mar;32(3):1-4

In Indonesia, Mendy J. Hatibie, MD, is Head of the Division of Plastic Surgery, University of Sam Ratulangi, Faculty of Medicine, Manado; Andi A. Islam, MD, PhD, is Dean and Professor, Department of Surgery, University of Hasanuddin, Faculty of Medicine, Makassar; Mochammad Hatta, MD, PhD, is Head of the Molecular Biology and Immunology Laboratory, University of Hasanuddin, Faculty of Medicine, Makassar; Yefta Moenadjat, MD, PhD is a Lecturer, Department of Surgery, University of Indonesia, Faculty of Medicine, Jakarta; Rudy H. Susilo, MD, is a general surgeon, Department of Surgery, University of Sam Ratulangi, Faculty of Medicine, Manado; and Leo Rendy, MD, is a general surgeon, Department of Surgery, University of Sam Ratulangi, Faculty of Medicine, Manado. The authors have disclosed no financial relationships related to this article. Submitted August 25, 2018; accepted in revised form October 9, 2018.

Background: The wound healing process includes inflammation, proliferation, and remodelling phases, the main features of which are inflammation, neoangiogenesis, and epithelialization. Hyperbaric oxygen therapy (HBOT) is one modality postulated to improve wound healing. The objective of this study was to determine whether HBOT could improve selected features of burn wound healing in an experimental rabbit model. Read More

Adv Skin Wound Care 2019 Mar;32(3):131-138

Barbara Delmore, PhD, RN, CWCN, MAPWCA, IIWCC-NYU, is Senior Nurse Scientist, Center for Innovations in the Advancement of Care, and Clinical Assistant Professor, Hansjörg Wyss, Department of Plastic Surgery, NYU Langone Health, New York. Elizabeth A. Ayello, PhD, RN, CWON, ETN, MAPWCA, FAAN, is the co-Editor-in-Chief of Advances in Skin & Wound Care; Faculty, Excelsior College School of Nursing, Albany, New York; President, World Council of Enterostomal Therapists; and President, Ayello Harris & Associates, Inc, Copake, New York. Hiske Smart, MA Nursing Science (PU for CHE), Hons B Soc Sc Nursing Science (UFS), RN, IIWCC-CAN, is Clinical Nurse Specialist, Wound Care and Hyperbaric Oxygen Therapy Unit, King Hamad University Hospital, Bahrain. Gulnaz Tariq, BSc, MS, IIWCC-CAN, is Wound & Skin Care Manager, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates (UAE). R. Gary Sibbald, MD, DSc (Hons), MEd, BSc, FRCPC (Med Derm), FAAD, MAPWCA, JM, is the co-Editor-in-Chief of Advances in Skin & Wound Care; Professor of Medicine and Public Health and Director, International Interprofessional Wound Care Course & Masters of Science in Community Health (Prevention & Wound Care), Dalla Lana Faculty of Public Health, University of Toronto, Ontario, Canada. Acknowledgments: The authors thank Salvacion Cruz and her team for assistance in data collection in the UAE; Gary Kwok for his efforts; and Evan X. Accardi for his tremendous help with inputting, organizing, and analyzing the data. As of January 2017, Dr Delmore is currently serving a 3-year term as a National Pressure Ulcer Advisory Panel (NPUAP) board member. Dr Ayello is a past NPUAP president and board member. The authors have disclosed no financial relationships related to this article. Submitted April 28, 2018; accepted in revised form July 23, 2018.

Pressure injuries/ulcers are a global health issue, and there is a need for clinicians from many countries and continents to express their opinions on the terminology change (pressure ulcer to injury) and revised staging definitions. A convenience, opinion survey sample of clinicians from the Western Asia Gulf Region enrolled in a yearlong wound care course participated by expressing their opinion about these changes. Results reveal support for the pressure injury terminology and the revised staging definitions. Read More

MedEdPORTAL 2018 Dec 21;14:10788. Epub 2018 Dec 21.

Clinical Instructor of Medicine, Department of Emergency Medicine, NewYork-Presbyterian Hospital/Columbia University Medical Center.

Introduction: Arterial gas embolism (AGE) is a rare but severe complication of scuba diving. While AGE is most commonly encountered in coastal areas with high volumes of recreational divers, at-risk populations exist throughout the United States, making basic knowledge of the disease important for all emergency medicine (EM) physicians.

Methods: We used a hypothetical simulation case to train EM residents on diagnosis and management of AGE. Read More

Am J Emerg Med 2019 Feb 10. Epub 2019 Feb 10.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan. Electronic address:

Background: The effects of hyperbaric oxygen therapy (HBOT) on mortality or morbidity in patients with carbon monoxide (CO) poisoning remain unknown. We examined the effects of HBOT on CO poisoning and further strived to delineate its inherent effects on specific subgroups of patients using a nationwide inpatient database.

Methods: We identified adult patients with CO poisoning who were registered in the Japanese Diagnosis Procedure Combination inpatient database from 2010 to 2016. Read More

Geriatr Gerontol Int 2019 Feb 20. Epub 2019 Feb 20.

Institute of Emergency and Critical Care Medicine, National Yang-Ming University, Taipei, Taiwan.

Aim: The older adult population is continuously growing worldwide and there is increasing use of medical recourse in older patients, especially for those requiring intensive care unit (ICU) care and mechanical ventilation (MV). The present study aimed to investigate the burden and predictors of post-ICU respiratory failure in older ICU patients weaned from MV.

Methods: In the present retrospective study, older ICU patients aged ≥60 years, who were successfully weaned from MV and discharged to the general ward from the ICU of Taipei Veterans General Hospital, Taipei, Taiwan, in 2011, were included. Read More

BMJ 2019 Feb 20;364:l758. Epub 2019 Feb 20.

Amsterdam University Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.

Kidney Int Rep 2019 Feb 9;4(2):231-244. Epub 2018 Oct 9.

Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Background: Calciphylaxis is a life-threatening complication of chronic kidney disease (CKD). To inform clinical practice, we performed a systematic review of case reports, case series, and cohort studies to synthesize the available treatment modalities and outcomes of calciphylaxis in patients with CKD.

Methods: Electronic databases were searched for studies that examined the uses of sodium thiosulfate, surgical parathyroidectomy, calcimimetics, hyperbaric oxygen therapy, and bisphosphonates for calciphylaxis in patients with CKD, including end-stage renal disease. Read More

Neuropsychiatr Dis Treat 2019 25;15:369-374. Epub 2019 Jan 25.

Department of Emergency, Zhuji People's Hospital of Zhejiang Province, Zhuji, Zhejiang, China,

Background: Given that the therapeutic effect of hyperbaric oxygen (HBO) therapy on traumatic brain injury (TBI) has been debated for a long time, it is necessary to clarify the mechanism underlying the effect of HBO on acute TBI.

Methods: This study investigated the effect of HBO therapy on neuronal apoptosis induced by acute TBI using the mouse model of TBI. The number of apoptotic cells and expression of apoptosis-associated factors (including caspase 3, pAkt/Akt, pGSK3β/GSK3β, and β-catenin) in pericontusional cortices of mice exposed to sham, TBI, and TBI + HBO treatment were measured and analyzed using TUNEL assay, quantitative reverse-transcription PCR, and Western blot. Read More

Dtsch Arztebl Int 2018 12;115(51-52):863-870

Department of Anaesthesiology and Intensive Care University Hospital Bonn (UKB), Bonn Clinic for Anesthesiology and Intensive Care Medicine, Hannover Medical School.

Background: The symptoms of carbon monoxide (CO) poisoning are nonspecific, ranging from dizziness and headache to unconsciousness and death. A German national guideline on the diagnosis and treatment of this condition is lacking at present.

Methods: This review is based on a selective literature search in the PubMed and Cochrane databases, as well as on existing guidelines from abroad and expert recommendations on diagnosis and treatment. Read More

ANZ J Surg 2019 Jan;89(1-2):E51

Division of Plastic Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.

Eur J Case Rep Intern Med 2019 23;6(1):001011. Epub 2019 Jan 23.

Internal Medicine Department, Hospital de Cascais, Cascais, Portugal.

Cerebral venous air embolism (CVAE) is an extremely rare phenomenon. Most reports of cerebral air embolism focus on the arterial territory, and consequently CVAE has remained poorly understood, especially regarding its pathophysiology and treatment. The authors describe an elderly male patient who was admitted through the Emergency Department with subacute confusion. Read More

Int J Endocrinol 2019 10;2019:2328505. Epub 2019 Jan 10.

Institute of Nuclear Sciences Vinca, University of Belgrade, Laboratory of Radiobiology and Molecular Genetics, Belgrade, Serbia.

This study aimed at examining the early effects of hyperbaric oxygen therapy (HBOT) on inducible nitric oxide synthase (iNOS) activity/expression in lymphocytes of type 1 diabetes mellitus (T1DM) patients. A group of 19 patients (mean age: 63 ± 2.1) with T1DM and with the peripheral arterial disease were included in this study. Read More

J Urol 2019 Feb 7. Epub 2019 Feb 7.

PARC Urology, Frisco, TX UNITED STATES.

Purpose: Increased complications following failed hypospadias repairs suggest impaired wound healing is a contributing factor. We used perioperative hyperbaric oxygen therapy (HBOT) to promote wound healing determined by graft take in staged tubularized autograft (STAG) reoperations using oral graft.

Methods: HBOT was recommended in patients having 3 or more failed hypospadias repairs, comprising 20 preoperative and 10 postoperative sessions. Read More

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):75-80. Epub 2019 Feb 8.

NeuroMuscularFunction/Research Group, School of Exercise & Sport Sciences, Department of Medical Sciences, University of Turin, Italy.

Objectives: Neuromuscular efficiency (NME) is impaired in fibromyalgia (FM). Hyperbaric oxygen therapy (HBOT) is a medical treatment using 100% of oxygen through an oxygen mask. HBOT in FM induces changes in cortical excitability and a secondary reduction in pain and muscle fatigue. Read More

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):63-69. Epub 2019 Feb 6.

Department of Rheumatology, ASST Fatebenefratelli-Sacco, Milan, Italy.

Objectives: Fibromyalgia (FM) is a syndrome of unknown aetiology that is characterised by widespread musculoskeletal pain, fatigue and disordered sleep, and often associated with neuropsychiatric and cognitive symptoms. Current treatment options are only partially effective, but hyperbaric oxygen therapy (HBOT) seems to be capable of relieving some of the symptoms. The aim of this study was to evaluate the efficacy and safety of HBOT after fewer sessions than generally used, chosen on the basis of pre-clinical and clinical data showing its rapid and sustained antinociceptive effect. Read More

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):81-89. Epub 2019 Feb 8.

Dipartimento di Biopatologia e Biotecnologie Mediche, Università di Palermo, Italy.

Objectives: Hyperbaric oxygen therapy (HBOT) has been used as treatment for different clinical conditions, including fibromyalgia (FM). HBOT modulates brain activity, ameliorates chronic pain and modifies the ratio of immune cells. Clinical studies have provided evidence that FM is associated with immune system dysregulation. Read More

J Craniofac Surg 2019 Feb 2. Epub 2019 Feb 2.

Dr. YOURhinoclinic (Private Clinic), Istanbul, Turkey.

Purpose: Loss of vision is an extremely rare and unexpected complication following a routine uncomplicated nasal surgery. In majority of patients, visual loss has attributed to retinal emboli which occur with retrograde flow of the intra-arterially injected agents into the nasal cavity or direct trauma to the optic nerve. In this report, the authors present a patient with unilateral decreased vision due to branch retinal artery occlusion soon after a routine nasal surgery. Read More

Dan Med J 2019 Feb;66(2)

Introduction: Patients with diabetic foot ulcers (DFU) suffer from diabetes-related complications and comor-bidities. Hyperbaric oxygen therapy (HBOT) is a treatment modality with limited capacity used in the treatment of DFUs. It is important to ensure that HBOT is offered to patients who are suitable for this treatment regarding effect, compliance and life expectancy. Read More

Hum Exp Toxicol 2019 Feb 5:960327119828124. Epub 2019 Feb 5.

Department of Emergency Medicine, Kecioren Training and Research Hospital, Ankara, Turkey.

Objective:: The aim of the study was to assess netrin-1 levels in carbon monoxide (CO) poisoning to determine its relationship with poisoning severity and neurotoxicity.

Methods:: This is a cross-sectional prospective study. The patients older than 18 years with CO poisoning were included. Read More

Med Gas Res 2018 Oct-Dec;8(4):181-184. Epub 2019 Jan 9.

Department of Radiology, University of North Dakota School of Medicine and Health Sciences, Bismarck, ND, USA.

A 58-year-old female was diagnosed with Alzheimer's dementia (AD) which was rapidly progressive in the 8 months prior to initiation of hyperbaric oxygen therapy (HBOT). Fluorodeoxyglucose (FDG) positron emission tomography (PET) brain imaging demonstrated global and typical metabolic deficits in AD (posterior temporal-parietal watershed and cingulate areas). An 8-week course of HBOT reversed the patient's symptomatic decline. Read More

Med Gas Res 2018 Oct-Dec;8(4):167-171. Epub 2019 Jan 9.

Department Department of Urology and Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.

Hyperbaric oxygen therapy (HBOT) has been used as an adjuvant treatment for multiple pathological states, which involves hypoxic conditions. Over the past 50 years, HBOT has been recommended and used in a wide variety of medical conditions, clinically in the treatment of ischemic or nonhealing wounds and radiation-injured tissue, and in the treatment of malignancy. The mechanism of this treatment is providing oxygen under pressure which is higher than the atmosphere thus increasing tissue oxygen concentration. Read More

Int J Surg 2019 Mar 1;63:34-42. Epub 2019 Feb 1.

Dept of Urology, Imperial College NHS Trust, UK.

Background: BK virus is a major cause of late onset haemorrhagic cystitis in patients undergoing Haematopoietic Cell Transplantation (HCT). The evidence for the management of BK Virus Associated Haemorrhagic Cystitis (BKV-HC) is limited. Much of the published data consists of non-randomised case series and case reports. Read More