Search Our Scientific Publications & Authors

Rev Esp Enferm Dig 2022 Jun 24. Epub 2022 Jun 24.

Gastroenterology, Stavanger University Hospital.

New treatment options beyond immunosuppression have emerged in recent years for patients with Crohn´s disease (CD), a chronic systemic condition affecting primarily the gut with great impact in the quality of life. The cause of CD is largely unknown, and a curative treatment is not yet available. In addition, despite the growing therapeutic armamentarium in recent years almost half of the patients don´t achieve a sustained response over time. Read More

J Neurooncol 2022 Jun 23. Epub 2022 Jun 23.

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Odette Cancer Centre, University of Toronto, 2075 Bayview Ave, Toronto, ON, M4N3M5, Canada.

Purpose: Stereotactic body radiation therapy (SBRT) is now considered a standard of care treatment option in the management of spine metastases. One of the most feared complications of spine SBRT is radiation myelopathy (RM).

Methods: We provided a narrative review of RM following spine SBRT based on review of the published literature, including data on spinal cord dose constraints associated with the risk of RM, strategies to mitigate the risk, and management options for RM. Read More

Ann Med Surg (Lond) 2022 Jun 31;78:103896. Epub 2022 May 31.

Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

Introduction: Trauma to the extremities is a common major health problem that requires special attention because it can have a dangerous impact on both the viability of the limb and the patient's life. Hyperbaric oxygen therapy is an alternative therapy hypothesized to improve the prognosis in lower extremity trauma.

Case Presentation: We present a series of 7 cases of lower extremity trauma treated with hyperbaric oxygen therapy: soft tissue loss, neglected chronic burn injury, high-voltage electrical burn, gas gangrene, crush injury, chemical burn, and excoriation with skin loss. Read More

Diving Hyperb Med 2022 Jun;52(2):149-153

Department of Underwater and Hyperbaric Medicine, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.

Intramuscular injections are one of the most common clinical procedures. The objectives of this case series are to analyse the role, timing and efficacy of hyperbaric oxygen treatment (HBOT) in the management of Nicolau syndrome (NS), an extremely rare complication of this common intervention. Clinical, demographic, laboratory and microbiological data extraction were performed through retrospective analysis of the medical records of all patients with NS who were referred for HBOT over a 10-year period with wounds, ischaemia, infection or necrosis at the injection site following drug injection; four patients with NS were included. Read More

Diving Hyperb Med 2022 Jun;52(2):126-135

Department of Anesthesia and Pain Management, University Health Network, Toronto, Ontario, Canada.

Introduction: As the COVID-19 pandemic evolves, new effective treatment options are essential for reducing morbidity and mortality as well as the strain placed on the healthcare system. Since publication of our initial review on hyperbaric oxygen treatment (HBOT) for hypoxaemic COVID-19 patients, interest in HBOT for COVID-19 has grown and additional studies have been published.

Methods: For this living systematic review update the previously published search strategy (excluding Google Scholar) was adopted with an extension from 01 February 2021 to 01 April 2022. Read More

Diving Hyperb Med 2022 Jun;52(2)

Department of Hyperbaric Medicine, Fiona Stanley Hospital, Murdoch WA, Australia.

Introduction: Limited evidence suggests that shorter recompression schedules may be as efficacious as the US Navy Treatment Table 6 (USN TT6) for treatment of milder presentations of decompression sickness (DCS). This study aimed to determine if divers with mild DCS could be effectively treated with a shorter chamber treatment table.

Methods: All patients presenting to the Fremantle Hospital Hyperbaric Medicine Unit with suspected DCS were assessed for inclusion. Read More

Diving Hyperb Med 2022 Jun;52(2):78-84

Helsinki University, Helsinki, Finland.

Introduction: Technical diving is increasing in popularity in Finland, and therefore the number of decompression illness (DCI) cases is also increasing among technical divers. Although hyperbaric oxygen treatment (HBOT) remains the standard of care, there are anecdotal reports of technical divers treating mild DCI symptoms themselves and not seeking a medical evaluation and possible recompression therapy. This study aimed to make an epidemiologic inventory of technical diving-related DCI symptoms, to establish the incidence of self-treatment and to determine the apparent effectiveness of different treatment methods. Read More

Andrology 2022 Jun 21. Epub 2022 Jun 21.

Urology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.

Introduction: Several urological conditions that share an impairment of tissue oxygenation can benefit from hyperbaric oxygen therapy (HBO), limited evidence is available on the impact of HBO in patients undergoing male-to-female (MtF) Gender Affirmation Surgery (GAS).

Aim: To evaluate the efficacy and safety of HBO as adjuvant treatment for surgical site infections in patients undergoing MtF GAS.

Methods: This research was conducted as an observational retrospective study. Read More

Clin Oncol (R Coll Radiol) 2022 Jun 14. Epub 2022 Jun 14.

Division of Radiation Oncology, Geneva University Hospital, Geneva, Switzerland; Faculty of Medicine, Geneva University, Geneva, Switzerland. Electronic address:

Aims: Although the results on acute and late toxicity of ultrahypofractionation are encouraging, data on safety in prostate cancer patients with a medical history of transurethral resection of the prostate (TURP) or adenomectomy remain scarce, especially in cases of repeated procedures. The aim of the present study was to report on long-term toxicities after stereotactic body radiotherapy (SBRT) of prostate cancer patients with previous surgical treatment of benign prostatic hyperplasia.

Materials And Methods: Among 150 patients treated with SBRT (median dose 36. Read More

Am J Emerg Med 2022 Jun 12. Epub 2022 Jun 12.

Department of Anesthesiology, Amsterdam University Medical Center, Amsterdam, the Netherlands; Department of Hyperbaric Medicine, Amsterdam University Medical Center, Amsterdam, the Netherlands.

Survival of airplane stowaways is rare. Here we report an exceptional case of successful treatment and full recovery. After a transcontinental flight an unconscious stowaway was discovered in a wheel well of a Boeing 747-400F. Read More

Wilderness Environ Med 2022 Jun 16. Epub 2022 Jun 16.

International Shark Attack File (ISAF), Florida Museum of Natural History, University of Florida, Gainesville, FL.

Herein we report an unprovoked shark attack on a scuba diver in New Caledonia. The species responsible for the attack was identified as a tiger shark (Galeocerdo cuvier), based on both the victim's testimony and forensic examination. The victim suffered significant loss of soft tissues from one thigh, which resulted in hemorrhagic shock. Read More

BMC Neurol 2022 Jun 18;22(1):225. Epub 2022 Jun 18.

Department of Neurosurgery, Shigatse People's Hospital, Tibet, China.

Background: Posterior reversible encephalopathy syndrome (PRES) is a disorder of reversible vasogenic brain oedema with acute neurologic symptoms. It is a rare but serious disease that affects the central nervous system. PRES is a rare complication of acute post-streptococcal glomerulonephritis (APSGN). Read More

High Alt Med Biol 2022 Jun;23(2):198-199

Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia.

Am J Case Rep 2022 Jun 12;23:e935534. Epub 2022 Jun 12.

Hyperbaric Oxygen Therapy Division, Department of Emergency Medicine, Kameda General Hospital, Kamogawa, Chiba, Japan.

BACKGROUND Hyperbaric oxygen (HBO₂) therapy in a multiplace chamber is the standard treatment for severe altitude decompression illness (DCI). However, some hospitals may only have a monoplace chamber. Herein, we present the case of a patient with severe altitude DCI caused by rapid decompression during an actual flight operation that was successfully treated through emergency HBO₂ therapy with the Hart-Kindwall protocol, a no-air-break tables with the minimal-pressure oxygen approach in a monoplace chamber due to unavailability of rapid access to a multiplace chamber. Read More

J Wound Care 2022 06;31(Sup6):S6-S10

Associate Professor, Director Spinal Cord Repair Laboratory, School of Human Sciences, University of Western Australia.

Zhongguo Yi Liao Qi Xie Za Zhi 2022 May;46(3):302-306

Techray Medical Technology Co. Ltd., Changsha, 410035.

Hyperbaric oxygen therapy is a method of breathing pure oxygen or high-concentration oxygen in a highpressure environment to treat hypoxic diseases and related diseases. According to clinical verification, this therapy has an irreplaceable effect on certain diseases and has gradually become a comprehensive clinical treatment. One of the main methods of certain diseases is widely recognized by the medical field at home and abroad. Read More

Front Surg 2022 20;9:877114. Epub 2022 May 20.

Department of Obsterics and Gynecology, The Second People's Hospital of Hefei (Hefei Hospital Affiliated to Anhui Medical University), An Hui, China.

Objective: This study aims to explore the effect of adjuvant hyperbaric oxygen therapy on ovarian function after laparoscopic ovarian cystectomy.

Methods: A total of 60 patients with ovarian cysts treated at our hospital from January 2018 to August 2020 were enrolled. According to the different treatment modalities, the patients were divided into the control and observation groups. Read More

Prim Care Diabetes 2022 May 31. Epub 2022 May 31.

University of Kansas Medical Center, Department of Otolaryngology, 3901 Rainbow Boulevard Mailstop 3010, Kansas City, KS 66160, USA. Electronic address:

Introduction: Olfactory dysfunction (OD) is highly prevalent amongst type 2 diabetes mellitus (DM2) patients and has many associated health risks. For example, OD can lead to poor nutrition, safety issues related to diminished hazard detection, and increased mortality rates. While limited research exists about therapeutics for DM2-associated OD, recovery of olfactory function is better studied in other pathologic states. Read More

Redox Biol 2022 07 27;53:102352. Epub 2022 May 27.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, China. Electronic address:

Hyperbaric oxygen therapy (HBOT), a technique through which 100% oxygen is provided at a pressure higher than 1 atm absolute (ATA), has become a well-established treatment modality for multiple conditions. The noninvasive nature, favorable safety profile, and common clinical application of HBOT make it a competitive candidate for several new indications, one of them being aging and age-related diseases. In fact, despite the conventional wisdom that excessive oxygen accelerates aging, appropriate HBOT protocols without exceeding the toxicity threshold have shown great promise in therapies against aging. Read More

Expert Rev Pharmacoecon Outcomes Res 2022 Jun 10:1-8. Epub 2022 Jun 10.

Health Technology Assessment Resource Centre, Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Background: Diabetic foot ulcer (DFU) is a common complication of diabetes. Hyperbaric oxygen therapy (HBOT) is an adjunct treatment that expedites the healing of DFU.

Aim: To evaluate the cost-utility of using standard wound care (SWC) plus HBOT as compared to SWC alone for the treatment of DFU from a societal perspective in the Indian context. Read More

J Obstet Gynaecol 2022 Jun 1:1-2. Epub 2022 Jun 1.

Hyperbaric Medicine Unit, Clinical Institute Città di Brescia, Brescia, Italy.

Carbon monoxide (CO) poisoning during pregnancy may cause deleterious effects to the fetus. Hyperbaric oxygen therapy (HBO) in pregnancy is proven to be safe and it is considered to be beneficial, reducing the severity of the fetal injuries. However, a number of issues are still to be discussed, among them the question of the carboxyhemoglobin (COHb) levels that trigger HBO therapy in pregnant CO poisoned patients. Read More

Biomed Res Int 2022 20;2022:6738959. Epub 2022 May 20.

Department of Plastic and Cosmetic Surgery, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, 518052 Guangdong, China.

Objective: Currently, autologous fat transplantation (AFT) still has a low graft survival rate. Elevation of the AFT graft survival rate is a challenge. This study investigated the effect of hyperbaric oxygen (HBO) on AFT. Read More

Clin Cosmet Investig Dent 2022 23;14:141-151. Epub 2022 May 23.

Orthodontic Laboratory, Hang Tuah University, Surabaya, Indonesia.

Purpose: The aim of this study is to analyze SMAD 3, integrin and VEGF expressions in the periodontal ligament during orthodontic tooth movement induced by hyperbaric oxygen therapy and .

Materials And Methods: Thirty were divided into 5 groups, namely, a normal control group (KN) without installation of helical springs or administration of HBOT and gel. The negative control K(-) had helical spring without administration of HBOT and gel for 14 days, while P1 had helical spring for 14 days then on day 3-14, gel was added. Read More

QJM 2022 May 26. Epub 2022 May 26.

Department of Ophthalmology, Tung Wah Eastern Hospital, Hong Kong.

Am J Emerg Med 2022 May 13;58:73-78. Epub 2022 May 13.

Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Background: Carbon monoxide poisoning (COP), resulting from accidental and intentional exposure, is a leading cause of fatal poisoning worldwide. Except for early death, neurological sequelae are common and impose a large burden on patients, caregivers, and the society.

Materials And Methods: This retrospective study included patients who visited the emergency departments (EDs) of the medical institutes of Chang Gung Memorial Hospital after COP with a carboxyhemoglobin level > 10% between January 2009 and October 2018. Read More

Metabolites 2022 May 23;12(5). Epub 2022 May 23.

Department of Anesthesiology, Amsterdam UMC, Location AMC, 1100 DD Amsterdam, The Netherlands.

Diving or hyperbaric oxygen therapy with increased partial pressures of oxygen (pO) can have adverse effects such as central nervous system oxygen toxicity or pulmonary oxygen toxicity (POT). Prevention of POT has been a topic of interest for several decades. One of the most promising techniques to determine early signs of POT is the analysis of volatile organic compounds (VOCs) in exhaled breath. Read More

Life (Basel) 2022 May 19;12(5). Epub 2022 May 19.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland.

Most SARS CoV-2 infections probably occur unnoticed or cause only cause a mild common cold that does not require medical intervention. A significant proportion of more severe cases is characterized by early neurological symptoms such as headache, fatigue, and impaired consciousness, including respiratory distress. These symptoms suggest hypoxia, specifically affecting the brain. Read More

Biomolecules 2022 Apr 30;12(5). Epub 2022 Apr 30.

Department of Pharmacology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

Hyperbaric oxygen therapy (HBOT) has been suggested as a potential adjunctive therapy for Parkinson's disease (PD). PD is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The aim of this study was to investigate the protective mechanisms of HBOT on neurons and motor function in a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD and 1-methyl-4-phenylpyridinium (MPP)-mediated neurotoxicity in SH-SY5Y cells on the potential protective capability. Read More

Front Physiol 2022 10;13:899568. Epub 2022 May 10.

Department of Anesthesiology, Amsterdam UMC Location AMC, Amsterdam, Netherlands.

The hyperbaric oxygen treatment table 6 (TT6) is widely used to manage dysbaric illnesses in divers and iatrogenic gas emboli in patients after surgery and other interventional procedures. These treatment tables can have adverse effects, such as pulmonary oxygen toxicity (POT). It is caused by reactive oxygen species' damaging effect in lung tissue and is often experienced after multiple days of therapy. Read More

J Foot Ankle Res 2022 May 25;15(1):40. Epub 2022 May 25.

Hall and Prior Health and Aged Care Group, Perth, Australia.

Background: Diabetes-related foot ulceration (DFU) has a substantial burden on both individuals and healthcare systems both globally and in Australia. There is a pressing need for updated guidelines on wound healing interventions to improve outcomes for people living with DFU. A national expert panel was convened to develop new Australian evidence-based guidelines on wound healing interventions for people with DFU by adapting suitable international guidelines to the Australian context. Read More