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Gastroenterol Res Pract 2021 18;2021:6662000. Epub 2021 May 18.

Division of Gastroenterology, Department of Internal Medicine, Inha University Hospital, Inha University College of Medicine, Incheon, Republic of Korea.

Methods: Forty patients with one or more risk factors for PEP were prospectively enrolled between June 2018 and November 2019. The cannulation was conducted in all patients using NKS as the primary cannulation technique. Success rate of biliary cannulation, biliary cannulation time, and adverse event rate were assessed. Read More

J Clin Gastroenterol 2021 May 28. Epub 2021 May 28.

Golestan Research Center of Gastroenterology and Hepatology Infectious Diseases Research Center Golestan Rheumatology Research Center, Golestan University of Medical Sciences Clinical Research Development Unit (CRDU), Sayyad-e-Shirazi Hospital, Golestan University of Medical Sciences, Gorgan Cancer Control Research Center, Cancer Control Foundation, Iran University of Medical Sciences, Tehran, Iran.

Background: Endoscopic retrograde cholangiopancreatography (ERCP) has an important role in the treatment of pancreaticobiliary disorders.

Goals: Considering the high prevalence and importance of postendoscopic retrograde cholangiopancreatography pancreatitis (PEP) and the controversial findings, we aimed to determine the effect of adding intravenous somatostatin to rectal indomethacin on the incidence of PEP in high-risk patients.

Study: In this prospective study, 530 patients underwent ERCP during March 2018 and February 2019. Read More

Medicine (Baltimore) 2021 Apr;100(16):e25598

Department of Emergency Medicine, Zhongshan Hospital, Dalian University, Dalian, China.

Background: Acute pancreatitis is the most common complication of Endoscopic Retrograde Cholangiopancreatography (ERCP). There was no conclusion on the prevention of Post-ERCP Pancreatitis (PEP) by Lactated Ringer Solution.

Aim: The purpose of this meta analyses is to determine whether aggressive hydration with Lactated Ringer Solution reduced the incidence of PEP. Read More

Clin Lab 2021 Apr;67(4)

Background: Serum amylase is secreted by salivary glands and pancreas and is used for the diagnosis of pancreatic and parotid diseases. A number of factors can elevate the level of serum amylase including pancreatic diseases, salivary disease, gastrointestinal diseases, liver diseases, gynecologic disease, cholecystitis, peritonitis, renal failure, and drug induced.

Methods: We reported a case with abnormally elevated serum amylase, namely hyperamylasemia. Read More

Wideochir Inne Tech Maloinwazyjne 2021 Mar 18;16(1):38-44. Epub 2020 Apr 18.

Department of General Surgery, Istanbul Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Introduction: Endoscopic retrograde cholangiopancreatography (ERCP) is a tool often used for treating and diagnosing pancreaticobiliary diseases. One of the important complications of ERCP is pancreatitis. Even though transient hyperamylasemia is a more common and benign situation, it must be distinguished from post-ERCP pancreatitis. Read More

BMC Gastroenterol 2021 Mar 4;21(1):102. Epub 2021 Mar 4.

Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, 520-2192, Japan.

Background: We investigated the utility and safety of a new uneven double-lumen sphincterotome in biliary cannulation in comparison with the conventional pancreatic guidewire (PGW) method.

Methods: We retrospectively evaluated 119 patients who required PGW placement because of difficult biliary cannulation. Endoscopic retrograde cholangiopancreatography (ERCP) was performed using a conventional ERCP catheter or a new uneven double-lumen sphincterotome. Read More

Medicine (Baltimore) 2021 Mar;100(9):e24604

Department of Critical Care Medicine, The People's Hospital of China Three Gorges University, The First People's Hospital of Yichang.

Abstract: Mortality of critically ill patients with coronavirus disease 2019 (COVID-19) was high. Aims to examine whether time from symptoms onset to intensive care unit (ICU) admission affects incidence of extra-pulmonary complications and prognosis in order to provide a new insight for reducing the mortality. A single-centered, retrospective, observational study investigated 45 critically ill patients with COVID-19 hospitalized in ICU of The Third People's Hospital of Yichang from January 17 to March 29, 2020. Read More

Exp Ther Med 2021 Mar 22;21(3):251. Epub 2021 Jan 22.

Endoscopy Center, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang 312000, P.R. China.

The study aimed to investigate the preventive and therapeutic significance of octreotide combined with lansoprazole on post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) and its effects on serum amylase (AMS), inflammatory factors and immune function. A total of 132 patients who underwent ERCP in Shaoxing People's Hospital (Shaoxing, China) were enrolled in the study and allocated into two groups: The study group (octreotide plus lansoprazole, 68 cases) and the control group (octreotide alone, 64 cases). The incidence of PEP and post-ERCP hyperamylasemia (PEH), the concentrations of serum AMS, interleukin-17 (IL-17) and tumor necrosis factor-α (TNF-α), as well as the T-lymphocyte population in peripheral blood were detected. Read More

HPB (Oxford) 2021 Jan 13. Epub 2021 Jan 13.

Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany. Electronic address:

Background: The clinical relevance of hyperamylasemia after distal pancreatectomy (DP) remains unclear and no internationally accepted definition of postoperative acute pancreatitis (POAP) exists. The aim of this study was to characterize POAP after DP and to assess the role of serum amylase (SA) in POAP.

Methods: Outcomes of 641 patients who had undergone DP between 2015 and 2019 were analyzed. Read More

Zhonghua Yi Xue Za Zhi 2021 Jan;101(4):276-279

Cholelithiasis Center, Shanghai East Hospital Affiliated to Tongji University, Shanghai 200120, China.

To explore whether the use of pancreatic stent combined with somatostatin can produce the synergistic effect of preventing acute pancreatitis (AP) and hyperamylasemia (HP) after endoscopic retrograde cholangiopancreatography (ERCP). From January 2019 to December 2019, the clinical data of 325 patients with ERCP were analyzed retrospectively in cholelithic center of Shanghai East Hospital Affiliated to Tongji University. According to the different methods of AP prevention, the patients were divided into the observation group (pancreatic stent and somatostatin) and the control group (pancreatic stent) and the incidence of AP and HP were compared. Read More

World J Transplant 2020 Dec;10(12):372-380

Department of General & Gastrointestinal Surgery, Hospital Universitario de Salamanca, Universidad de Salamanca, Salamanca 37007, Spain.

The aim of the work was to analyze and expose the donor and recipient risk factors in pancreas transplantation. In the following paper, we exposed the 2018 Spanish Consensus Document on Donor and Recipient Selection Criteria for Pancreas Transplantation. An assessment of the previous Selection Criteria for Donors and Recipients of Pancreas Transplantation, published in 2005 by the Spanish Pancreas Transplant Group (GETP) and the National Transplant Organization (ONT) was performed. Read More

Biomed Res Int 2020 17;2020:3531907. Epub 2020 Dec 17.

Department of Digestive Diseases, Huashan Hospital, Fudan University, China.

Methods: A retrospective study on SJS patients was conducted at a tertiary medical center. All patients diagnosed as SJS, with available serum amylase index, were included. Clinical data of all subjects were retrospectively collected and analyzed. Read More

J Laparoendosc Adv Surg Tech A 2021 Feb 11;31(2):176-182. Epub 2020 Dec 11.

Department of Percutaneous Surgery, DAICIM Foundation (Teaching, Research, Assistance in Minimal Invasive Surgery), Buenos Aires, Argentina.

The relationship between obesity with common bile duct stone (CBDS) is close and increases after a Roux-en-Y gastric bypass (RYGB). Due to the anatomical modification, direct endoscopic access is not always possible. For this reason, image-guided surgery (IGS) by percutaneous transhepatic biliary drainage (PTBD) of the common bile duct (CBD) could be a first-line approach for the treatment of post-RYGB choledocholithiasis. Read More

Ann Palliat Med 2020 Nov;9(6):4029-4037

Department of General Surgery, Pudong New Area People's Hospital, Shanghai University of Medicine & Health Sciences, Shanghai, China.

Background: Prophylactic pancreatic stent placement (PSP) and rectal indomethacin suppository are recommended to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in high-risk cases. Clinical trials on the use of nitroglycerin to reduce PEP have reached no definitive conclusion. Our study aimed to determine whether treatment with rectal indomethacin plus nitroglycerin could eliminate the need for PSP in patients. Read More

Infez Med 2020 Dec;28(4):507-515

Unit of Internal Medicine, Maggiore Hospital, Local Health Unit of Bologna, Bologna, Italy.

The gastrointestinal system may be affected by COVID-19 infection with an incidence variable from 3% up to 79%. Several works show that the pancreas, both in its exocrine and endocrine function, can be affected by this viral infection, although this organ has been poorly analyzed in this current epidemic context. This mini-review aims to provide a summary of available studies on exocrine pancreas involvement during COVID-19 infection. Read More

Surgery 2021 04 28;169(4):740-741. Epub 2020 Nov 28.

Tata Memorial Centre, Mumbai, India. Electronic address:

J Assoc Physicians India 2020 Dec;68(12):58-60

Professor, Lady Hardinge Medical College, New Delhi.

Background And Aim: Coronavirus disease 2019 (COVID 2019) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may cause multisystem dysfunction. We studied pancreatic injury (serum amylase and serum lipase levels) in COVID-19 patients.

Methods: A retrospective study involving 42 COVID-19 patients (diagnosed by real-time PCR) admitted to a tertiary care hospital was conducted. Read More

Radiother Oncol 2021 02 11;155:182-187. Epub 2020 Nov 11.

Southern Tohoku BNCT Research Center, Koriyama, Japan; Department of Radiation Oncology, Southern Tohoku General Hospital, Koriyama, Japan.

Background And Purpose: Boron neutron capture therapy (BNCT) can be performed without reactors due to development of cyclotron-based epithermal neutron source (C-BENS), which is optimized for treatment for deeper-seated tumors. The purpose of this study was to evaluate efficacy and safety of cyclotron-based BNCT with borofalan (B) for recurrent or locally advanced head and neck cancer.

Materials And Methods: In this open-label, phase II JHN002 trial of BNCT using C-BENS with borofalan (B), patients with recurrent squamous cell carcinoma (R-SCC) or with recurrent/locally advanced non-squamous cell carcinoma (R/LA-nSCC) of the head and neck were intravenously administered 400 mg/kg borofalan (B), followed by neutron irradiation. Read More

J Formos Med Assoc 2021 Apr 9;120(4):1090-1099. Epub 2020 Nov 9.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan, ROC; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan, ROC. Electronic address:

Background/purpose: The evidence provided by syntheses of the preventative effects of gabexate mesilate against pancreatitis among patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) is limited and highly heterogeneous. To enhance the understanding of this topic, this study aimed to provide overview of gabexate mesilate on preventing post ERCP pancreatitis (PEP) by synthesizing all relevant randomized controlled trials (RCTs).

Methods: We searched three databases for relevant RCTs. Read More

Int J Gen Med 2020 24;13:699-704. Epub 2020 Sep 24.

Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Republic of Korea.

Background: Lenvatinib, a novel multi-target tyrosine kinase inhibitor, has been approved for treating differentiated thyroid cancer. Herein, we describe a rare case of acute pancreatitis that developed during lenvatinib treatment in a 65-year-old man with recurrent thyroid cancer.

Case Presentation: The patient was admitted to our department following a complaint of acute-onset epigastric pain and indigestion. Read More

Surg Laparosc Endosc Percutan Tech 2020 Oct 12;31(2):208-214. Epub 2020 Oct 12.

Department of Gastroenterology, School of Medicine, Amasya University, Amasya, Turkey.

Background: Rectal indomethacin or a topical spray of epinephrine to the papilla of Vater has each shown efficacy alone in the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP). We supposed that a submucosal epinephrine injection would be more effective and longer acting than a topical epinephrine spray and therefore would further reduce the incidence of PEP.

Patients And Methods: A retrospective analysis was conducted of 412 patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) between January 2017 and December 2019. Read More

Surgery 2021 02 25;169(2):369-376. Epub 2020 Sep 25.

Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.

Background: Serum amylase activity greater than the institutional upper limit of normal (hyperamylasemia) on postoperative day 0-2 has been suggested as a criterion to define postoperative acute pancreatitis after pancreatoduodenectomy, but robust evidence supporting this definition is lacking.

Background: To assess the clinical impact of hyperamylasemia after pancreatoduodenectomy and to define postoperative acute pancreatitis.

Methods: Data of 1,235 consecutive patients who had undergone pancreatoduodenectomy between January 2010 and December 2014 were extracted from a prospective database and analyzed. Read More

Medicine (Baltimore) 2020 Sep;99(37):e22051

Departments of Gastroenterology.

Addressing pancreaticobiliary disorders concomitant with gastroesophageal varices remains challenging. The goal of this study was to evaluate and compare the efficacy and safety of endoscopic retrograde cholangiopancreatography (ERCP) in cirrhotic and noncirrhotic patients with gastroesophageal varices.We retrospectively analyzed the data of consecutive patients with gastroesophageal varices who underwent ERCP. Read More

Endoscopy 2020 Sep 9. Epub 2020 Sep 9.

Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan.

Background:  This study aimed to compare the markers of potential pancreatic injury during antegrade double-balloon endoscopy (DBE) using the newly developed ultrathin EN-580XP system and the conventional EN-580T system.

Methods:  Patients who were scheduled for antegrade DBE during daily clinical practice were enrolled. Clinical background, adverse events, and laboratory data of patients were compared between those who underwent endoscopy using the EN-580XP system and those in whom the EN-580T system was used. Read More

J Am Vet Med Assoc 2020 Sep;257(6):635-641

Case Description: A 15-year-old 0.412-kg (0.906-lb) sexually intact male eclectus parrot () was evaluated because its owners found it lethargic and dyspneic at the bottom of its cage. Read More

Updates Surg 2020 Dec;72(4):1297-1298

General Surgery Department, Mansoura University Hospitals, Mansoura University, PO: 35516, Mansoura, Egypt.

Table 4: The Column "Biochemical" the entire row "Hyperamylasemia" is missing the updated Table 4 has been copied below. Read More

Sci Rep 2020 07 10;10(1):11477. Epub 2020 Jul 10.

Department of Gastroenterological Endoscopy, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan road, Xigang district, Dalian, 116011, Liaoning, China.

In order to evaluate the effectiveness of various methods we applied to decrease the influence of periampullary diverticula (PAD) on the success rate and complications of endoscopic retrograde cholangiopancreatography (ERCP) in the treatment of common bile duct (CBD) stones, we enrolled patients with CBD stones who had been treated by ERCP in our hospital between January 2015 and December 2018. According to the presence of PAD, the patients were divided into a PAD group and a non-PAD group. The rate of complete stone removal in the first session, the rate of overall stone removal, the frequency of application of mechanical lithotripsy, and procedure-related complications, including bleeding, hyperamylasemia, pancreatitis, perforation, and infection of biliary tract were recorded. Read More

Surgery 2021 02 5;169(2):377-387. Epub 2020 Jul 5.

Department of General and Pancreatic Surgery - The Pancreas Institute, University of Verona Hospital Trust, Italy. Electronic address:

Background: Postoperative hyperamylasemia is a frequent finding after pancreatoduodenectomy, but its incidence and clinical implications have not yet been analyzed systematically. The aim of this review is to reappraise the concept of postoperative hyperamylasemia with postoperative acute pancreatitis, including its definition, interpretation, and correlation.

Methods: Online databases were used to search all available relevant literature published through June 2019. Read More

Gastrointest Endosc 2021 03 29;93(3):586-593. Epub 2020 Jun 29.

Department of Gastroenterology, SMS Medical College and Hospitals, Jaipur, India.

Background And Aims: Precut sphincterotomy, usually performed after prolonged and failed cannulation, is considered a risk factor for post-ERCP pancreatitis (PEP). There are limited studies on primary needle-knife precut for the prevention of PEP. The aim of this study was to assess the safety and efficacy of primary precut. Read More