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    3736 results match your criteria Hyperaldosteronism Primary

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    Laparoscopic Adrenalectomy for Conn's Syndrome is Beneficial to Patients and is Cost Effective in England.
    J Invest Surg 2017 May 12:1-7. Epub 2017 May 12.
    a Department of Endocrine Surgery, Churchill Hospital , Oxford University Hospitals NHS Trust , Oxford , United Kingdom.
    Purpose: Adrenalectomy has the potential to cure or improve the control of hypertension in patients with primary hyperaldosteronism due to unilateral adrenal adenoma (Conn's syndrome). This study assesses the patients' perception of, and costs associated with, laparoscopic adrenalectomy for Conn's syndrome.

    Materials And Methods: Clinical, radiological, operative, and pathological data were collected on patients undergoing adrenalectomy for Conn's syndrome over 8-years period in a UK tertiary referral center. Read More

    A case of confirmed primary hyperaldosteronism diagnosed despite normal screening investigations.
    N Z Med J 2017 May 12;130(1455):129-132. Epub 2017 May 12.
    Department of Surgery, Wellington Regional Hospital, Newtown, Wellington.
    Primary hyperaldosteronism is a common cause of hypertension in the adult population. We report a case of histologically and biochemically confirmed hyperaldosteronism related to an adrenal adenoma, where initial screening and biochemical tests were potentially misleading. The case highlights the importance of clinical suspicion in the current diagnostic approach to primary hyperaldosteronism. Read More

    Clinical Utility of the Adrenocorticotropin Stimulation Test with/without Dexamethasone Suppression for Definitive and Subtype Diagnosis of Primary Aldosteronism.
    Int J Mol Sci 2017 Apr 30;18(5). Epub 2017 Apr 30.
    Endocrinology and Diabetes Center, Yokohama Rosai Hospital, Yokohama 222-0036, Japan.
    The adrenocorticotropin (ACTH) stimulation test (AST) has been reported to be useful for diagnosing primary aldosteronism (PA), particularly for differentiating PA subtypes under 1-mg dexamethasone suppression (DS). The aim of our study was to clarify the effect of 1-mg DS on AST results. A retrospective cohort study was conducted using data for 48 patients (PA: 30/48). Read More

    Outcomes analysis of surgical and medical treatments for patients with primary aldosteronism.
    Endocr J 2017 Apr 29. Epub 2017 Apr 29.
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
    Patients with aldosterone-producing adenomas are treated using surgery, and patients with idiopathic hyperaldosteronism receive medical treatment using mineralocorticoid receptor antagonists (MRAs). However, the outcomes of surgical and medical treatment for primary aldosteronism (PA) remain unclear. Therefore, we compared the outcomes of surgical and medical treatment for PA and aimed to identify a specific subgroup that might benefit from medical treatment. Read More

    Familial hyperaldosteronism type III.
    J Hum Hypertens 2017 Apr 27. Epub 2017 Apr 27.
    Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Torino, Torino, Italy.
    Primary aldosteronism is the most common form of endocrine hypertension. This disorder comprises both sporadic and familial forms. Four familial forms of primary aldosteronism (FH-I to FH-IV) have been described. Read More

    Somatic and inherited mutations in primary aldosteronism.
    J Mol Endocrinol 2017 Jul 11;59(1):R47-R63. Epub 2017 Apr 11.
    INSERMUMRS_970, Paris Cardiovascular Research Center, Paris, France.
    Primary aldosteronism (PA), the most common form of secondary hypertension, is caused in the majority of cases by unilateral aldosterone-producing adenoma (APA) or bilateral adrenal hyperplasia. Over the past few years, somatic mutations in KCNJ5, CACNA1D, ATP1A1 and ATP2B3 have been proven to be associated with APA development, representing more than 50% of sporadic APA. The identification of these mutations has allowed the development of a model for APA involving modification on the intracellular ionic equilibrium and regulation of cell membrane potential, leading to autonomous aldosterone overproduction. Read More

    Adrenal venous sampling in a patient with left inferior vena cava.
    Clin Case Rep 2017 Apr 2;5(4):482-485. Epub 2017 Mar 2.
    Department of Cardiovascular Medicine JR Hiroshima Hospital 3-1-36 Futabanosato Higashi-ku Hiroshima 732-0057 Japan.
    Adrenal venous sampling (AVS), although difficult, is recommended for patients with primary aldosteronism (PA) to diagnose the subtype. Recognizing anatomical variation is key to a successful AVS. We report on a patient with PA and left inferior vena cava (IVC) whose left adrenal vein drained directly into the IVC. Read More

    Histopathological Classification of Cross-Sectional Image-Negative Hyperaldosteronism.
    J Clin Endocrinol Metab 2017 Apr;102(4):1182-1192
    Department of Pathology, and.
    Context: Approximately half of patients with primary aldosteronism (PA) have clinically evident disease according to clinical (hypertension) and/or laboratory (aldosterone and renin levels) findings but do not have nodules detectable in routine cross-sectional imaging. However, the detailed histopathologic, steroidogenic, and pathobiological features of cross-sectional image-negative PA are controversial.

    Objective: To examine histopathology, steroidogenic enzyme expression, and aldosterone-driver gene somatic mutation status in cross-sectional image-negative hyperaldosteronism. Read More

    How to Escape from Primary Aldosteronism? News and Views on an Adrenal Disorder of Salt Retention.
    Horm Metab Res 2017 Mar 28;49(3):151-163. Epub 2017 Mar 28.
    Division of Endocrinology and Metabolism, Rostock University Medical Center, Rostock, Germany.
    The last years have seen substantial progress in primary aldosteronism (PA), which is the most common cause of secondary hypertension. Many programs have been established around the world to meet the needs in healthcare and the management of patients with PA according to published guidelines and clinical protocols. Systematic analysis of emerging data and meticulous scientific work have informed us on the molecular basis of the disease and helped to characterize hereditary forms of PA. Read More

    PENTRAXIN 3 AS A NEW CARDIOVASCULAR MARKER IN ADRENAL ADENOMAS.
    Endocr Pract 2017 Mar 23. Epub 2017 Mar 23.
    From: 1Department of Endocrinology and Metabolism, Diskapi Teaching and Research Hospital, Ankara, Turkey.
    Background: Pentraxin 3 (PTX3) is an acute-phase glycoprotein, which is increased in patients with cardiovascular disease (CVD) and considered as a predictor of CVD in the general population. Both functional and nonfunctional adrenal tumors are associated with a higher risk of cardiovascular events and mortality. We aimed to investigate plasma PTX3 levels in patients with functioning and nonfunctioning adrenal tumors and to determine its relationship with cardiovascular risk factors. Read More

    Renin angiotensin aldosterone system altered in resistant hypertension in Sub-Saharan African diabetes patients without evidence of primary hyperaldosteronism.
    JRSM Cardiovasc Dis 2017 Jan-Dec;6:2048004017695006. Epub 2017 Feb 1.
    Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; National Obesity Centre, Diabetes and Metabolic Diseases Unit, Yaoundé Central Hospital, Yaoundé, Cameroon.
    Background: The renin-angiotensin-aldosterone system may be altered in patients with resistant hypertension. This study aimed to evaluate the relation between renin-angiotensin-aldosterone system activity and resistant hypertension in Cameroonian diabetes patients with resistant hypertension.

    Methods: We carried out a case-control study including 19 diabetes patients with resistant hypertension and 19 diabetes patients with controlled hypertension matched to cases according to age, sex and duration of hypertension since diagnosis. Read More

    A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases.
    J Mol Biol 2017 Apr 11;429(8):1114-1142. Epub 2017 Mar 11.
    Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA. Electronic address:
    Melanoma antigen (MAGE) genes are conserved in all eukaryotes and encode for proteins sharing a common MAGE homology domain. Although only a single MAGE gene exists in lower eukaryotes, the MAGE family rapidly expanded in eutherians and consists of more than 50 highly conserved genes in humans. A subset of MAGEs initially garnered interest as cancer biomarkers and immunotherapeutic targets due to their antigenic properties and unique expression pattern that is primary restricted to germ cells and aberrantly reactivated in various cancers. Read More

    Acid-base disturbances in nephrotic syndrome: analysis using the CO2/HCO3 method (traditional Boston model) and the physicochemical method (Stewart model).
    Clin Exp Nephrol 2017 Mar 13. Epub 2017 Mar 13.
    Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan.
    Background: The Stewart model for analyzing acid-base disturbances emphasizes serum albumin levels, which are ignored in the traditional Boston model. We compared data derived using the Stewart model to those using the Boston model in patients with nephrotic syndrome.

    Methods: Twenty-nine patients with nephrotic syndrome and six patients without urinary protein or acid-base disturbances provided blood and urine samples for analysis that included routine biochemical and arterial blood gas tests, plasma renin activity, and aldosterone. Read More

    Continuum of Renin-Independent Aldosteronism in Normotension.
    Hypertension 2017 May 13;69(5):950-956. Epub 2017 Mar 13.
    From the Program for Adrenal Disorders and Endocrine Hypertension, Department of Endocrinology, School of Medicine, Pontificia Universidad Catolica De Chile, Santiago (R.B., F.J.G., C.F.); and Division of Renal Medicine (G.H.) and Center for Adrenal Disorders, Division of Endocrinology, Diabetes and Hypertension (J.B., G.W., A.V.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
    Primary aldosteronism is a severe form of autonomous aldosteronism. Milder forms of autonomous and renin-independent aldosteronism may be common, even in normotension. We characterized aldosterone secretion in 210 normotensives who had suppressed plasma renin activity (<1. Read More

    Hypokalemia and Pendrin Induction by Aldosterone.
    Hypertension 2017 May 13;69(5):855-862. Epub 2017 Mar 13.
    From the Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan (N.X., K.I., S.U., S.S.); Department of Nephrology, Tianjin First Central Hospital, China (N.X., W.X.C.); and Division of Clinical Epigenetics, Research Center for Advanced Science and Technology (D.H., T.F., S.S.) and Department of Clinical Laboratory, School of Medicine (T.S.), The University of Tokyo, Japan.
    Aldosterone plays an important role in regulating Na-Cl reabsorption and blood pressure. Epithelial Na(+) channel, Na(+)-Cl(-) cotransporter, and Cl(-)/HCO3(-) exchanger pendrin are the major mediators of Na-Cl transport in the aldosterone-sensitive distal nephron. Existing evidence also suggests that plasma K(+) concentration affects renal Na-Cl handling. Read More

    Licorice-induced hypertension: a case of pseudohyperaldosteronism due to jelly bean ingestion.
    Postgrad Med 2017 Apr 15;129(3):329-331. Epub 2017 Feb 15.
    d Division of Endocrinology and Metabolism , St. Joseph's Health Care , London , Canada.
    Hypertension is one of the most common problems encountered in the primary care setting. Numerous secondary causes of hypertension exist and are potentially reversible. The ability to screen for such causes and manage them effectively may spare patients from prolonged medical therapy and hypertensive complications. Read More

    [Long-term blood pressure outcome after unilateral adrenalectomy for primary hyperaldosteronism].
    Prog Urol 2017 May 1;27(6):389-394. Epub 2017 Mar 1.
    Service d'endocrinologie, maladies métaboliques, diabétologie et nutrition, université de Picardie Jules-Verne, CHU d'Amiens, 80000 Amiens, France.
    Objectives: To evaluate long-term results of adrenalectomy for primary aldosteronism (PA) and to identify prognostic factors associated.

    Methods: Exhaustive retrospective review of all consecutive patients undergoing adrenalectomy for PA between 2002 and 2013 in our department. All patients underwent preoperative: clinical evaluation (age, sex, height, weight, systolic and diastolic BP under treatment, identification of anti-hypertension treatment), biological evaluation (potassium, renin, aldosterone) and radiological evaluation (CT and/or MRI). Read More

    Radiofrequency ablation treatment for aldosterone-producing adenomas.
    Curr Opin Endocrinol Diabetes Obes 2017 Jun;24(3):169-173
    Division of Interventional Radiology, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States.
    Purpose Of Review: To review the current status of radiofrequency ablation as a primary treatment for hyperfunctioning adrenal nodules, predominantly aldosterone-producing adenomas (APAs).

    Recent Findings: Radiofrequency ablation is an established treatment for focal benign and malignant lesions, including metastatic disease to the adrenal gland. Hyperaldosteronism is the leading cause of secondary hypertension with up to 80% due to APA, statistically the most common functioning adrenal nodule. Read More

    Transarterial embolization of a hyperfunctioning aldosteronoma in a patient with bilateral adrenal nodules.
    Radiol Case Rep 2017 Mar 29;12(1):87-91. Epub 2016 Nov 29.
    Department of Vascular and Interventional Radiology, University of Miami Miller School of Medicine, 1611 NW 12th Ave, Miami, FL 33136-1005, USA.
    Primary hyperaldosteronism often results in resistant hypertension and hypokalemia, which may lead to cardiovascular and cerebrovascular complications. Although surgery is first line treatment for unilateral functioning aldosteronomas, minimally invasive therapies may be first line for certain patients such as those who cannot tolerate surgery. We present a case of transarterial embolization (TAE) of an aldosteronoma. Read More

    NP-59 test for preoperative localization of primary hyperaldosteronism.
    Langenbecks Arch Surg 2017 Mar 21;402(2):303-308. Epub 2017 Feb 21.
    University Hospital La Princesa, Madrid, Spain.
    Purpose: Adrenal venous sampling is generally considered the gold standard to identify unilateral hormone production in cases of primary hyperaldosteronism. The aim of this study is to evaluate whether the iodine-131-6-β-iodomethyl-19-norcholesterol (NP-59) test may represent an alternative in selected cases.

    Methods: Patients submitted to laparoscopic adrenalectomy for suspected primary hyperaldosteronism (n = 27) were retrospectively reviewed. Read More

    Low dose-eplerenone treatment decreases aortic stiffness in patients with resistant hypertension.
    J Clin Hypertens (Greenwich) 2017 Feb 17. Epub 2017 Feb 17.
    Divisions of Nephrology and Intensive Care Medicine, Department of Internal Medicine, University Hospital Würzburg, and Comprehensive Heart Failure Center, Würzburg, Germany.
    Vascular damage is aggravated in animal models of hypertension with mineralocorticoid (MR) excess and in hypertensive patients with primary hyperaldosteronism. MR antagonism has shown to provide effective blood pressure (BP)-control in patients with treatment resistant hypertension (TRH), but the concurrent effects on the vasculature have not been examined. In a randomized, double-blinded, placebo-controlled parallel-group study, 51 patients with TRH received either eplerenone 50 mg or placebo for 6 months together with additional antihypertensives titrated to achieve a BP target of <140/90 mm Hg. Read More

    Increased Aldosterone Release During Head-Up Tilt in Early Primary Hypertension.
    Am J Hypertens 2017 May;30(5):484-489
    Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.
    Background: Hyperaldosteronism is well known cause of secondary hypertension. However, the importance of aldosterone for the much larger group of patients with primary hypertension is less clear. We hypothesized that in young subjects with primary hypertension, the rise of plasma aldosterone levels in response to head-up tilt testing as a stress stimulus is exaggerated. Read More

    Primary Aldosteronism as a Risk Factor for Vertebral Fracture.
    J Clin Endocrinol Metab 2017 Apr;102(4):1237-1243
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Shimane 693-8501, Japan, and.
    Context: Some observational studies have revealed an association between excessive aldosterone levels and reduced bone mineral density (BMD). However, whether patients with primary aldosteronism (PA) are at higher risk of fracture than healthy individuals remains unclear.

    Objective: This study aimed to clarify whether PA represents a risk factor for vertebral fracture (VF). Read More

    Stroke disclosing primary aldosteronism: Report on three cases and review of the literature.
    Ann Endocrinol (Paris) 2017 Feb 4;78(1):9-13. Epub 2017 Feb 4.
    Department of Neurology, Military Hospital, 1008, Montfleury, 1089 Tunis, Tunisia.
    Objectives: There is a growing evidence of increased risk of cerebrovascular events in primary aldosteronism (PA). Nevertheless, acute neurologic ailment as presenting feature of PA is uncommon. Our aim is to highlight the diagnosis challenges in stroke unmasking PA and to discuss the underlying physiopathology and management dilemmas. Read More

    Anatomical Variations of the Right Adrenal Vein: Concordance Between Multidetector Computed Tomography and Catheter Venography.
    Hypertension 2017 Mar 30;69(3):428-434. Epub 2017 Jan 30.
    From the Department of Diagnostic Radiology (K.O., H.O., Y.T., T.M., K.S., K.T.), Department of Urology (Y.A.), and Division of Nephrology, Endocrinology, and Vascular Medicine (R.M., F.S.), Tohoku University Hospital, Sendai, Japan.
    Adrenal venous sampling is the most reliable diagnostic procedure to determine surgical indications in primary aldosteronism. Because guidelines recommend multidetector computed tomography (CT) to evaluate the adrenal gland, some past reports used multidetector CT as a guide for adrenal venous sampling. However, the detailed anatomy of the right adrenal vein and its relationship with an accessory hepatic vein remains uncertain. Read More

    Novel Approach to Establishing an Aldosterone: Renin Ratio Cutoff for Primary Aldosteronism.
    Hypertension 2017 Mar 9;69(3):450-456. Epub 2017 Jan 9.
    From the Division of Endocrinology and Metabolism, Department of Medicine (A.A.L., G.A.K.) and Calgary Laboratory Services, Department of Pathology and Laboratory Medicine, Section of Clinical Biochemistry (D.J.O., A.C., H.S.), University of Calgary, Alberta, Canada.
    Direct renin concentration is replacing plasma renin activity in many laboratories for the investigation of primary aldosteronism, which may have a significant impact on the resulting aldosterone:renin ratios. We sought to develop a population-based approach to establishing an aldosterone:renin ratio cutoff when transitioning between assays. A population-based study was performed in Calgary, Alberta, Canada of 4301 individuals who received testing from January 2012 to November 2015. Read More

    Hypokalemic Paralysis Complicated by Concurrent Hyperthyroidism and Hyperaldosternoism: A Case Report.
    Am J Case Rep 2017 Jan 4;18:12-16. Epub 2017 Jan 4.
    Department of Medicine, Fu-Jen Catholic University School of Medicine, Taipei, Taiwan.
    BACKGROUND Thyrotoxic periodic paralysis (TPP) is commonly observed in patients with acute paralysis and hyperthyroidism. However, there is a possibility of secondary causes of hypokalemia in such a setting. CASE REPORT Herein, we present the case of a 38-year-old woman with untreated hypertension and hyperthyroidism. Read More

    Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives.
    Steroids 2017 Feb 29;118:76-92. Epub 2016 Dec 29.
    Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
    Spironolactone is a well-known multi-target drug and is specifically used for the treatment of high blood pressure and heart failure. It is also used for the treatment of edema, cirrhosis of the liver, malignant, pediatric, nephrosis and primary hyperaldosteronism. Spironolactone in association with thiazide diuretics treats hypertension and in association with furosemide treats bronchopulmonary dyspepsia. Read More

    Digenic mutations involving both the BSND and GJB2 genes detected in Bartter syndrome type IV.
    Int J Pediatr Otorhinolaryngol 2017 Jan 26;92:17-20. Epub 2016 Oct 26.
    Department of Otolaryngology, Head & Neck Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. Electronic address:
    Bartter syndrome type IV, characterized by salt-losing nephropathies and sensorineural deafness, is caused by mutations of BSND or simultaneous mutations of both CLCNKA and CLCNKB. GJB2 is the primary causative gene for non-syndromic sensorineural deafness and associated with several syndromic sensorineural deafness. Owing to the rarity of Bartter syndrome, only a few mutations have been reported in the abovementioned causative genes. Read More

    Improvement of Bone Turnover Markers and Bone Mineral Density following treatment of Primary Aldosteronism.
    Minerva Endocrinol 2016 Dec 20. Epub 2016 Dec 20.
    Endocrine Unit, Department of Medicine, University Kebangsaan Malaysia Medical Center, Cheras, Kuala Lumpur, Malaysia -
    Background: Recent studies showed association between hyperaldosteronism and low bone density among patients with primary aldosteronism (PA) due to secondary hyperparathyroidism. Our objective is to assess bone turnover markers (BTM) and bone mineral density (BMD) of PA patients compared to essential hypertension.

    Methods: This was an open-label, prospective, case-controlled study, conducted over 12 months. Read More

    Genetic characterization of a mouse line with primary aldosteronism.
    J Mol Endocrinol 2017 Feb 13;58(2):67-78. Epub 2016 Dec 13.
    Medizinische Klinik und Poliklinik IVEndocrine Research Unit, Klinikum der Universität München, LMU, Munich, Germany.
    In an attempt to define novel genetic loci involved in the pathophysiology of primary aldosteronism, a mutagenesis screen after treatment with the alkylating agent N-ethyl-N-nitrosourea was established for the parameter aldosterone. One of the generated mouse lines with hyperaldosteronism was phenotypically and genetically characterized. This mouse line had high aldosterone levels but normal creatinine and urea values. Read More

    A Novel Method of Adrenal Venous Sampling via an Antecubital Approach.
    Cardiovasc Intervent Radiol 2017 Mar 8;40(3):388-393. Epub 2016 Dec 8.
    Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishilu, Xicheng District, Beijing, 100037, China.
    Purpose: Currently, almost all adrenal venous sampling (AVS) procedures are performed by femoral vein access. The purpose of this study was to establish the technique of AVS via an antecubital approach and evaluate its safety and feasibility.

    Materials And Methods: From January 2012 to June 2015, 194 consecutive patients diagnosed as primary aldosteronism underwent AVS via an antecubital approach without ACTH simulation. Read More

    Plasma adrenocorticotropic hormone but not aldosterone is correlated with blood pressure in patients with aldosterone-producing adenomas.
    J Clin Hypertens (Greenwich) 2017 Mar 5;19(3):280-286. Epub 2016 Dec 5.
    Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
    Although plasma aldosterone concentration (PAC) varies depending on primary aldosteronism (PA) subtypes, patients with different subtypes may have similar blood pressure (BP). The authors hypothesized that hormones other than aldosterone might influence BP in PA patients. A total of 73 PA cases, including 30 cases of aldosterone-producing adenomas (APAs), 29 cases of bilateral hyperaldosteronism, and 24 control cases of essential hypertension were enrolled retrospectively. Read More

    Hypertension Cure Following Laparoscopic Adrenalectomy for Hyperaldosteronism is not Universal: Trends Over Two Decades.
    World J Surg 2017 Apr;41(4):986-990
    Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan.
    Background: Laparoscopic adrenalectomy has been established as a standard surgical method for unilateral primary aldosteronism. Meanwhile, the background characteristics of the patients undergoing adrenalectomy have changed over the last 20 years. The aim of this study was to investigate the changes in hypertension cure rates after laparoscopic adrenalectomy during the last two decades. Read More

    Preclinical and Early Clinical Profile of a Highly Selective and Potent Oral Inhibitor of Aldosterone Synthase (CYP11B2).
    Hypertension 2017 Jan 21;69(1):189-196. Epub 2016 Nov 21.
    From the Clinical Pharmacology (K.B., D.S., M.-L.D.), Biostatistics (G.P.), Discovery (K.A.), Pharmaceutical Sciences (S.M., M.C.D.V.M.), and Translational Medicine, Cardiovascular Diseases (P.F.), Pharma Research and Early Development, Roche Innovation Center Basel, Switzerland; and Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, United Kingdom (M.J.B).
    Primary hyperaldosteronism is a common cause of resistant hypertension. Aldosterone is produced in the adrenal by aldosterone synthase (AS, encoded by the gene CYP11B2). AS shares 93% homology to 11β-hydroxylase (encoded by the gene CYP11B1), responsible for cortisol production. Read More

    Scoring system for the diagnosis of bilateral primary aldosteronism in the outpatient setting before adrenal venous sampling.
    Clin Endocrinol (Oxf) 2017 Apr 19;86(4):467-472. Epub 2016 Dec 19.
    Division of General Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
    Objective: The only reliable method for subtyping primary aldosteronism (PA) is adrenal venous sampling (AVS), which is costly and time-consuming. Considering the limited availability of AVS, it would be helpful to obtain information on the diagnosis of bilateral hyperaldosteronism (BHA) from routine tests. We aimed to establish new, simple criteria for outpatients to diagnose BHA from PA before AVS. Read More

    Adrenal vein sampling in primary aldosteronism: concordance of simultaneous vs sequential sampling.
    Eur J Endocrinol 2017 Feb 11;176(2):159-167. Epub 2016 Nov 11.
    Department of RadiologyCentre Hospitalier de l'Université de Montréal (CHUM), Montréal, Quebec, Canada
    Objective: Many investigators believe that basal adrenal venous sampling (AVS) should be done simultaneously, whereas others opt for sequential AVS for simplicity and reduced cost. This study aimed to evaluate the concordance of sequential and simultaneous AVS methods.

    Design And Methods: Between 1989 and 2015, bilateral simultaneous sets of basal AVS were obtained twice within 5 min, in 188 consecutive patients (59 women and 129 men; mean age: 53. Read More

    Cardiac Dysfunction in Association with Increased Inflammatory Markers in Primary Aldosteronism.
    Endocrinol Metab (Seoul) 2016 Dec 3;31(4):567-576. Epub 2016 Nov 3.
    Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea.
    Background: Oxidative stress in primary aldosteronism (PA) is thought to worsen aldosterone-induced damage by activating proinflammatory processes. Therefore, we investigated whether inflammatory markers associated with oxidative stress is increased with negative impacts on heart function as evaluated by echocardiography in patients with PA.

    Methods: Thirty-two subjects (mean age, 50. Read More

    Abnormal gel flotation caused by contrast media during adrenal vein sampling.
    Biochem Med (Zagreb) 2016 Oct;26(3):444-450
    Laboratory of Clinical Biochemistry, Department of Life and Reproduction Sciences, University of Verona, Italy.
    Introduction: During adrenal venous sampling (AVS) procedure, radiologists administer a contrast agent via the catheter to visualize the proper catheter position.

    Materials And Methods: A patient with primary aldosteronism diagnostic-hypothesis was admitted for AVS. A venogram was performed to
confirm the catheter's position with 2mL of Iopamidol 300 mg/mL. Read More

    A Novel Phenotype of Familial Hyperaldosteronism Type III: Concurrence of Aldosteronism and Cushing's Syndrome.
    J Clin Endocrinol Metab 2016 Nov 12;101(11):4290-4297. Epub 2016 Jul 12.
    Department of Endocrinology (A.T., F.W.), Key Laboratory of Endocrinology, Ministry of Health, and Departments of Urology (G.L., Y.Z.) and Clinical Laboratory (D.Z.), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China; The Key Laboratory of Genome Sciences and Information (J.J.), Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; Department of Endocrinology (Z.Y.), Affiliated Hospital of the Inner Mongolia Medical University, Hohhot 010050, China; and Hypertension Center (J.C.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
    Context: To date, all the familial hyperaldosteronism type III (FH-III) patients reported presenting with typical primary aldosteronism (PA), without showing other adrenal hormone abnormalities.

    Objective: This study characterized a novel phenotype of FH-III and explored the possible pathogenesis.

    Patients And Methods: A male patient presented with severe hypertension and hypokalemia at the age of 2 years and developed Cushing's syndrome at 20 years. Read More

    Disordered zonal and cellular CYP11B2 enzyme expression in familial hyperaldosteronism type 3.
    Mol Cell Endocrinol 2017 Jan 25;439:74-80. Epub 2016 Oct 25.
    Division of Endocrinology, Henry Ford Health System, Detroit, MI, United States.
    Three forms of familial primary aldosteronism have been recognized. Familial Hyperaldosteronism type 1 (FH1) or dexamethasone suppressible hyperaldosteronism, FH2, the most common form of as yet unknown cause(s), and FH3. FH3 is due to activating mutations of the potassium channel gene KCNJ5 that increase constitutive and angiotensin II-induced aldosterone synthesis. Read More

    CACNA1H Mutations Are Associated With Different Forms of Primary Aldosteronism.
    EBioMedicine 2016 Nov 4;13:225-236. Epub 2016 Oct 4.
    INSERM, UMRS_970, Paris Cardiovascular Research Center, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Génétique, Paris, France. Electronic address:
    Primary aldosteronism (PA) is the most common form of secondary hypertension. Mutations in KCNJ5, ATP1A1, ATP2B3 and CACNA1D are found in aldosterone producing adenoma (APA) and familial hyperaldosteronism (FH). A recurrent mutation in CACNA1H (coding for Cav3. Read More

    Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues.
    Hypertension 2016 Dec 24;68(6):1424-1431. Epub 2016 Oct 24.
    From the Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.); Clinical Pharmacology Unit, Department of Medicine, University of Cambridge (J.Z.), University of Cambridge Metabolic Research Laboratories, Wellcome Trust MRC Institute of Metabolic Science (B.L., G.S.H.Y.), Cambridge University Hospitals NHS Foundation Trust (S.G.N.), Addenbrooke's Hospital, United Kingdom; and Department of Medicine, Faculty of Medicine, The National University of Malaysia (UKM) Medical Centre, Kuala Lumpur (E.A.B.A.).
    Primary aldosteronism is present in ≈10% of hypertensives. We previously performed a microarray assay on aldosterone-producing adenomas and their paired zona glomerulosa and fasciculata. Confirmation of top genes validated the study design and functional experiments of zona glomerulosa selective genes established the role of the encoded proteins in aldosterone regulation. Read More

    Primary Aldosteronism: Diagnosis and Management.
    Am J Med Sci 2016 Oct 1;352(4):391-398. Epub 2016 Jul 1.
    Department of Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.
    Primary aldosteronism (PA) is an important and commonly unrecognized cause of secondary hypertension. Idiopathic hyperaldosteronism and aldosterone-producing adenomas account for more than 95% of PA and are characterized, respectively, by bilateral or unilateral involvement of the adrenal glands. When there is suspicion for the presence of PA, a plasma aldosterone to renin ratio should be obtained initially. Read More

    [Primary hyperaldosteronism due to unilateral adrenal hyperplasia with surgical resolution].
    Hipertens Riesgo Vasc 2016 Oct - Dec;33(4):155-158. Epub 2016 Apr 15.
    Servicio de Endocrinología y Nutrición, Hospital Universitario Doctor Peset, Valencia, España; Departamento de Medicina, Universidad de Valencia, Valencia, España; Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, España.
    Unilateral adrenal hyperplasia is a rare cause of primary hyperaldosteronism (around a 3%) that has surgical treatment. A case of a patient with hypertension resistant to conventional therapy in treatment with 7 drugs who presented with primary hyperaldosteronism due to unilateral adrenal hyperplasia is presented. A left adrenalectomy was performed, and the patient had a good clinical response, with no need of any drug after 2 years of surgery. Read More

    Risk factors for renal impairment revealed after unilateral adrenalectomy in patients with primary aldosteronism.
    Medicine (Baltimore) 2016 Jul;95(27):e3930
    aDepartment of Medicine, Division of Nephrology bBiostatistics and Clinical Epidemiology Center cDepartment of Surgery dDepartment of Medicine, Division of Endocrinology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Primary aldosteronism (PA) may induce significant decline of renal function and structural damage of kidney. However, it is difficult to evaluate accurate renal function in patients with PA, because glomerular hyperfiltration and aldosterone escape can conceal renal impairment. In this retrospective cohort study, we compared changes in renal function after unilateral adrenalectomy between patients with PA and patients with other adrenal diseases. Read More

    OS 35-09 LONG-TERM OUTCOME OF SURGICALLY- AND MEDICALLY-TREATED PATIENTS OF THE PRIMARY ALDOSTERONISM PREVALENCE IN HYPERTENSIVES (PAPY) STUDY.
    J Hypertens 2016 Sep;34 Suppl 1 - ISH 2016 Abstract Book:e401
    Department of Medicine, University of Padova, Italy.
    Objective: PA causes excess cardiovascular (CV) damage, but whether it worsens prognosis remained uncertain as there are no prospective studies. To compare long-term outcome of the 1125 patients recruited in the PAPY study.

    Design And Method: 11. Read More

    SY 14-3 PRIMARY ALDOSTERONISM IN RESISTANT HYPERTENSION.
    J Hypertens 2016 Sep;34 Suppl 1 - ISH 2016 Abstract Book:e369
    University of Alabama at Birmingham, U.S.A.
    : Resistant hypertension refers to patients with difficult-to-treat hypertension, generally defined as needing three or more medications of different classes, including, if tolerated, a diuretic. Observational studies indicate that the prevalence of resistant hypertension based on the preceding definition of needing 3 or medications for blood pressure (BP) control is approximately 15-20% of patients being treated for hypertension. However, causes of pseudoresistance are common, including poor BP technique, poor adherence, white coat effects, and under-treatment, all of which must be identified in order to distinguish apparent resistance from true treatment resistance. Read More

    BR 04-1MANAGEMENT OF TREATMENT-RESISTANT HYPERTENSION.
    J Hypertens 2016 Sep;34 Suppl 1 - ISH 2016 Abstract Book:e198
    University of Edinburgh, United Kingdom.
    Treatment-resistant hypertension (TRH) is defined as the failure to achieve an office BP target of <140/90 mmHg (<130/80 mmHg in patients with chronic kidney disease (CKD) or diabetes) in patients with hypertension (HT), despite adherence to at least 3 antihypertensive medications at optimal tolerated doses, ideally including a diuretic (Calhoun et al., Circulation 2008). TRH identifies patients with hard-to-treat HT, who might benefit from specialist investigation and treatment. Read More

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