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    Acute kidney injury due to multiple Hymenoptera stings-a clinicopathological study.
    Clin Kidney J 2017 Aug 28;10(4):532-538. Epub 2017 Mar 28.
    Community Medicine, Indira Gandhi Medial College, Shimla, Himachal Pradesh, India.
    Background: Acute kidney injury (AKI) after multiple Hymenoptera stings is well known but still a rare phenomenon.

    Methods: We conducted a retrospective study of the clinicopathological spectrum of AKI due to multiple Hymenoptera stings over 13 years (July 2003-June 2016).

    Results: A total of 35 patients were diagnosed with AKI due to multiple Hymenoptera stings. Read More

    Component-resolved diagnostics to direct in venom immunotherapy: important steps towards precision medicine.
    Clin Exp Allergy 2018 Jan 13. Epub 2018 Jan 13.
    Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
    Stings of Hymenoptera can induce IgE-mediated systemic and even fatal allergic reactions. Venom-specific immunotherapy (VIT) is the only disease-modifying and curative treatment of venom allergy. However, choosing the correct venom for VIT represents a necessary prerequisite for efficient protection against further anaphylactic sting reactions after VIT. Read More

    Anti-Inflammatory Activity of Crude Venom Isolated from Parasitoid Wasp, Bracon hebetor Say.
    Mediators Inflamm 2017 29;2017:6978194. Epub 2017 Oct 29.
    Laboratory of Veterinary Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
    Pest control in the agricultural fields, a major concern globally, is currently achieved through chemical or biological methods. Chemical methods, which leave toxic residue in the produce, are less preferred than biological methods. Venoms injected by stings of various wasps that kill the pest is considered as the examples of the biological method. Read More

    Venom immunotherapy in patients with allergic reactions to insect stings.
    Expert Rev Clin Immunol 2018 Jan 8;14(1):53-59. Epub 2017 Dec 8.
    c Allergy Unit , Sant'Anna Hospital, ASST Lariana , Como , Italy.
    Introduction: Allergy to Hymenoptera (Apis mellifera, Vespula species, Polistes species, Vespa crabro) venom can be safely and effectively treated by venom immunotherapy (VIT), which in the 40 years since its introduction has been able to prevent reactions to stings, and to treatment as well, though systemic reactions, occasionally severe, are possible. Areas covered: We reviewed the recent literature on VIT by searching in PubMed for the terms 'venom immunotherapy' and 'Hymenoptera venom immunotherapy' to highlight the current status of VIT and the likely development in the coming years. Expert commentary: VIT, provided the correct choice of the venom and adequate venom preparations and maintenance doses are used, is a treatment of great value in preventing systemic reactions to Hymenoptera stings. Read More

    Immunological differences between insect venom-allergic patients with and without immunotherapy and asymptomatically sensitized subjects.
    Allergy 2017 Nov 23. Epub 2017 Nov 23.
    Department of Dermatology and Venerology, Medical University of Graz, Graz, Austria.
    Background: Currently available tests are unable to distinguish between asymptomatic sensitization and clinically relevant Hymenoptera venom allergy. A reliable serological marker to monitor venom immunotherapy (VIT) does also not exist. Our aim was to find reliable serological markers to predict tolerance to bee and vespid stings. Read More

    The sting of a honey bee: An unusual subconjunctival foreign body.
    Indian J Ophthalmol 2017 Nov;65(11):1226-1228
    Tej Kohli Cornea Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India.
    Ocular foreign bodies (FBs) are often encountered in clinical practices. However, there are cases in which the presence of the FB is difficult to diagnose based on mere history taking and/or clinical examination. We herein present a case of unusual subconjunctival foreign body in the form of the sting of a honey bee in a 63-year-old farmer. Read More

    Skin Test Reactivity to Hymenoptera Venom after Venom Immunotherapy Correlates Inversely with the IgG/IgE Ratio.
    Int Arch Allergy Immunol 2017 9;174(3-4):190-199. Epub 2017 Nov 9.
    Allergy Unit, Department of Dermatology, University and University Hospital of Zurich, Zurich, Switzerland.
    Background: Skin test reactivity to hymenoptera venom and venom-specific IgE are important for diagnosing venom allergy and deciding on the appropriate allergen for venom immunotherapy (VIT). Longitudinal data on skin test reactivity during VIT and their correlation with venom-specific immunoglobulin (Ig)E and IgG are scarce.

    Methods: We retrospectively analyzed shifts in skin test reactivity and serum levels of venom-specific IgE and IgG in patients allergic to hymenoptera venom before the initiation of VIT with ultrarush therapy and after ≥3 years of VIT. Read More

    Bee or Wasp Sting.
    Wounds 2017 Sep;29(9):E70-E72
    University of Calgary, Calgary, Alberta, Canada; and Alberta Children's Hospital, Calgary, Alberta, Canada.
    While jogging in a local park in Hong Kong, a 55-year-old, previously healthy man was stung on the ventral aspect of his right wrist. The tiny stinger was gently removed with nail cutters and examined under a microscope at 80x magni cation; plucking the stinger is ill- advised as this may inject more venom into the wounded site. Two days after stinging, the microscopic appearance of the stinger con rmed the diagnosis to be from a bee instead of a wasp or other insect. Read More

    Stings of the Ant Wasmannia auropunctata (Hymenoptera: Formicidae) as Cause of Punctate Corneal Lesions in Humans and Other Animals.
    J Med Entomol 2017 Nov;54(6):1783-1785
    Wilkes Honors College, Florida Atlantic University, 5353 Parkside Drive, Jupiter, FL 33458.
    Numerous researchers have observed a form of punctate corneal lesions causing leukomas (corneal opacities) in humans, domestic animals, and wild animals in different parts of the world. This condition has been reported under different names, including West Indian (or Caribbean) punctate keratopathy, West Indian dots, tropical punctate keratopathy, Rice's keratopathy, Florida keratopathy, and Florida spots. Many of these cases, appear to have a common cause, the stings of a small red ant, Wasmannia auropunctata (Hymenoptera: Formicidae), originally from the Neotropics, but spread to other parts of the world through human commerce. Read More

    ABO blood groups, Rhesus factor, and anaphylactic reactions due to Hymenoptera stings.
    Ann Agric Environ Med 2017 Sep 5;24(3):428-430. Epub 2017 Jun 5.
    Department of Allergology, Clinical Immunology and Internal Diseases, L. Rydygier Collegium Medicum, Bydgoszcz, Poland.
    Introduction: Numerous publications indicate that the prevalence of some infectious, neoplastic and immunological diseases are associated with ABO blood groups.

    Objective: The aim of this study was to verify whether ABO and Rh blood groups are associated with severe anaphylactic reactions after Hymenoptera stings.

    Material And Methods: A study was undertaken of 71,441 Caucasian subjects living in the same geographic area. Read More

    Wasp sting induced STEMI with complete coronary artery occlusion: a case of Kounis syndrome.
    BMJ Case Rep 2017 Sep 7;2017. Epub 2017 Sep 7.
    Lancashire Cardiac Centre, Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool, UK.
    A 45-year-old previously healthy man with minimal coronary artery disease on imaging presented with an acute MI after sustaining a wasp sting following previous non-eventful exposures throughout his life. This is the first case of Kounis syndrome with optical coherence tomography imaging and proven IgE wasp venom hypersensitivity. The Hymenoptera venom is composed of allergenic proteins and vasoactive amines which are responsible for venom toxicity. Read More

    Component-resolved diagnosis in hymenoptera allergy.
    Allergol Immunopathol (Madr) 2017 Jul 21. Epub 2017 Jul 21.
    Servicio de Alergología, Hospital Universitario de Guadalajara, Guadalajara, Spain.
    Component-resolved diagnosis based on the use of well-defined, properly characterised and purified natural and recombinant allergens constitutes a new approach in the diagnosis of venom allergy. Prospective readers may benefit from an up-to-date review on the allergens. The best characterised venom is that of Apis mellifera, whose main allergens are phospholipase A2 (Api m1), hyaluronidase (Api m2) and melittin (Api m4). Read More

    Two Cases of Acute Kidney Injury Due to Multiple Wasp Stings.
    Wilderness Environ Med 2017 Sep 18;28(3):249-252. Epub 2017 Jul 18.
    Departments of Nephrology (Dr Vikrant) and Community Medicine (Dr Parashar), Indira Gandhi Medical College, Shimla, India.
    Acute kidney injury (AKI) is an unusual complication of wasp stings. Treatment of established AKI is largely supportive but the preventive strategies are not well documented. This is a report of 2 human cases that developed AKI after multiple wasp stings (Vespa magnifica). Read More


    Which immunotherapy product is better for patients allergic to Polistes venom? A laboratory and clinical study.
    PLoS One 2017 7;12(7):e0180270. Epub 2017 Jul 7.
    Department of Medicine and Surgery, University of Parma, Parma, Italy.
    Background: Venom immunotherapy (VIT) is highly effective in preventing allergic reactions to insect stings, but the appropriate venom must be used to achieve clinical protection. In patients with multiple positive results to venoms, molecular allergy diagnostics or CAP-inhibition may identify the causative venom. Concerning allergy to venom from Polistes spp. Read More

    Individual perception of bees: Between perceived danger and willingness to protect.
    PLoS One 2017 29;12(6):e0180168. Epub 2017 Jun 29.
    Department of Biology Education, University of Bayreuth, Bayreuth, Germany.
    The current loss of biodiversity has found its way into the media. Especially the loss of bees as pollinators has recently received much attention aiming to increase public awareness about the consequence of pollinator loss and strategies for protection. However, pollinating insects like bees often prompt considerable anxiety. Read More

    Preventive actions of allergen immunotherapy: the facts and the effects in search of evidence.
    Clin Mol Allergy 2017 15;15:13. Epub 2017 Jun 15.
    Medicine and Surgery Department, University of Parma, via Gramsci n.14, 43126 Parma, Italy.
    Allergen immunotherapy (AIT) is the only treatment that works on the causes of allergy. Available AIT nowadays are subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) for allergic rhinitis and asthma, while for allergy to Hymenoptera venom only subcutaneous route is recommended. A bulk of trials and meta-analyses demonstrated that efficacy and safety of AIT in decreasing allergic clinical symptoms and use of rescue medications, while its preventive capacity is yet under investigation. Read More

    A distinct biomolecular profile identifies monoclonal mast cell disorders in patients with idiopathic anaphylaxis.
    J Allergy Clin Immunol 2018 Jan 16;141(1):180-188.e3. Epub 2017 Jun 16.
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
    Background: Clonal mast cell disorders are known to occur in a subset of patients with systemic reactions to Hymenoptera stings. This observation has prompted the question of whether clonal mast cell disorders also occur in patients with idiopathic anaphylaxis (IA).

    Objective: We sought to determine the prevalence of clonal mast cell disorders among patients with IA, criteria to identify those patients who require a bone marrow biopsy, and whether the pathogenesis of IA involves a hyperresponsive mast cell compartment. Read More

    Clinical Characteristics of Allergy to Hymenoptera Stings.
    Pediatr Emerg Care 2017 Jun 13. Epub 2017 Jun 13.
    From the Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Objective: The purpose of this study was to evaluate the clinical characteristics of allergy to stings from the Hymenoptera order of insects in a hospital in Thailand.

    Methods: A descriptive retrospective analytical study was carried out in inpatients and outpatients suffering from Hymenoptera stings from 2009 to 2013 in Siriraj Hospital.

    Results: Medical records of 386 patients with an allergy to Hymenoptera stings were evaluated. Read More

    Allergen-specific immunotherapy of Hymenoptera venom allergy - also a matter of diagnosis.
    Hum Vaccin Immunother 2017 Oct 12;13(10):2467-2481. Epub 2017 Jun 12.
    a Center of Allergy and Environment (ZAUM) , Technical University of Munich and Helmholtz Center Munich, Member of the German Center of Lung Research (DZL) , Munich , Germany.
    Stings of hymenoptera can induce IgE-mediated hypersensitivity reactions in venom-allergic patients, ranging from local up to severe systemic reactions and even fatal anaphylaxis. Allergic patients' quality of life can be mainly improved by altering their immune response to tolerate the venoms by injecting increasing venom doses over years. This venom-specific immunotherapy is highly effective and well tolerated. Read More

    Acute kidney injury complicating bee stings - a review.
    Rev Inst Med Trop Sao Paulo 2017 Jun 1;59:e25. Epub 2017 Jun 1.
    Universidade Federal do Ceará, Faculdade de Medicina, Departamento de Medicina Clínica, Fortaleza, Ceará, Brazil.
    Bee stings can cause severe reactions and have caused many victims in the last years. Allergic reactions can be triggered by a single sting and the greater the number of stings, the worse the prognosis. The poisoning effects can be systemic and can eventually cause death. Read More

    Safety and efficacy of venom immunotherapy: a real life study.
    Postepy Dermatol Alergol 2017 Apr 13;34(2):159-167. Epub 2017 Apr 13.
    Clinical Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Lodz, Poland.
    Introduction: Venom immunotherapy (VIT) is recommended as the first-line treatment for patients allergic to Hymenoptera venom.

    Aim: To analyze the safety and efficacy of VIT in a real life setting.

    Material And Methods: One hundred and eighty patients undergoing VIT were studied to evaluate the safety, efficacy, incidence and nature of symptoms after field stings and adverse reactions to VIT. Read More

    Component Resolved Diagnosis in Hymenoptera Anaphylaxis.
    Curr Allergy Asthma Rep 2017 Jun;17(6):38
    Department of Dermatology and Allergy Biederstein, Technische Universität München, Biedersteiner Straße 29, 80802, Munich, Germany.
    Purpose Of Review: Hymenoptera anaphylaxis is one of the leading causes of severe allergic reactions and can be fatal. Venom-specific immunotherapy (VIT) can prevent a life-threatening reaction; however, confirmation of an allergy to a Hymenoptera venom is a prerequisite before starting such a treatment. Component resolved diagnostics (CRD) have helped to better identify the responsible allergen. Read More

    Fatal Anaphylaxis to Yellow Jacket Stings in Mastocytosis: Options for Identification and Treatment of At-Risk Patients.
    J Allergy Clin Immunol Pract 2017 Sep - Oct;5(5):1264-1271. Epub 2017 May 10.
    Department of Allergology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
    Background: Patients with indolent systemic mastocytosis (ISM) are at risk for severe anaphylactic reactions to yellow jacket (YJ) stings while demonstration of sensitization can be challenging because specific IgE (sIgE) levels are regularly below 0.35 kUA/L. The implication of missing YJ allergy is illustrated by a case of fatal anaphylaxis. Read More

    Arthropod Envenomation in North America.
    Emerg Med Clin North Am 2017 May;35(2):355-375
    Section of Emergency Medicine, University of Chicago, Chicago, IL, USA.
    Arthropods (phylum Arthopoda) account for a higher percentage of morbidity and mortality to humans than do mammalian bites, snake bites, or marine envenomation. They are ubiquitous in domestic dwellings, caves, and campsites and in wilderness settings such as deserts, forests, and lakes. Although arthropods are most intrusive during warmer months, many are active throughout the winter, particularly indoors. Read More

    Long-Term Follow-Up of Children after Venom Immunotherapy: Low Adherence to Anaphylaxis Guidelines.
    Int Arch Allergy Immunol 2017 6;172(3):167-172. Epub 2017 Apr 6.
    Division of Pediatric Pneumology and Allergy, University Hospital for Children and Adolescents, Leipzig, Germany.
    Background: Data on the long-term outcome of children after specific venom immunotherapy (VIT) are limited. Therefore, we assessed sting recurrence and anaphylaxis relapse rates as well as adherence to anaphylaxis guidelines with regard to the availability of emergency equipment and education status.

    Methods: For this long-term survey, data of 311 children with a history of anaphylactic reactions to hymenoptera stings were collected by chart review. Read More

    Decontamination Work and the Long-term Increase in Hospital Visits for Hymenoptera Stings Following the Fukushima Nuclear Disaster.
    Disaster Med Public Health Prep 2017 Oct 8;11(5):545-551. Epub 2017 Mar 8.
    1Department of Surgery,Minamisoma Municipal General Hospital,Minamisoma,Fukushima,Japan.
    Objective: Animals, including arthropods, are one health threat that can be affected by disasters. This institution-based study aimed to assess trends in Hymenoptera stings following the 2011 Fukushima nuclear disaster.

    Methods: We reviewed the medical records of patients with hymenopteran stings who visited Minamisoma Municipal General Hospital, located 23 km from Fukushima Daiichi Nuclear Power Plant, from March 2005 to March 2016. Read More

    Public Medical Preparedness at the "Swiss Wrestling and Alpine Games 2013": Descriptive Analysis of 1,533 Patients Treated at the Largest 3-Day Sporting Event in Switzerland.
    Emerg Med Int 2017 6;2017:9162095. Epub 2017 Feb 6.
    Department for Visceral Surgery and Medicine, Division of Acute Care Surgery, Bern University Hospital, Bern, Switzerland.
    Introduction. Medical preparedness at mass gatherings is challenging, as little is known about the optimal planning. Most studies and case reports are based on mass casualty incidents, so the results cannot be extrapolated to mass gatherings. Read More

    Kidney injury in a dog following bee sting-associated anaphylaxis.
    Can Vet J 2017 Mar;58(3):265-269
    University of Florida College of Veterinary Medicine - Small Animal Clinical Sciences, Gainesville, Florida, USA (Buckley, Corrie, Schaer); Canada West Veterinary Specialists - Emergency & Critical Care, Vancouver, British Columbia (Bandt).
    This report describes a case of honeybee envenomation in a dog that developed anaphylaxis after being stung by approximately 10 bees. The dog subsequently developed acute kidney injury. The dog had a previous mild increase in blood urea nitrogen with normal creatinine, possibly indicating an insidious chronic renal degenerative process that went into acute decompensation at the time of bee envenomation. Read More

    American Academy of Asthma, Allergy & Immunology membership experience with venom immunotherapy in chronic medical conditions and pregnancy, and in young children.
    Allergy Asthma Proc 2017 Mar;38(2):121-129
    Background: Few data exist regarding the use of venom immunotherapy (VIT) in specific high-risk chronic medical conditions and pregnancy, and in young children.

    Methods: A Web-based survey was sent to American Academy of Asthma Allergy & Immunology members to explore their VIT experience in potential high-risk medical conditions and pregnancy, and in young children. Major problems were defined as "activation of underlying disease and/or VIT not well tolerated (systemic adverse events) and/or VIT discontinued for medical reasons. Read More

    Key Issues in Hymenoptera Venom Allergy: An Update.
    J Investig Allergol Clin Immunol 2017;27(1):19-31
    Hospital Universitario Clínico San Carlos, Madrid, Spain.
    In this review, the Hymenoptera Allergy Committee of the SEAIC analyzes the most recent scientific literature addressing problems related to the diagnosis of hymenoptera allergy and to management of venom immunotherapy. Molecular diagnosis and molecular risk profiles are the key areas addressed. The appearance of new species of hymenoptera that are potentially allergenic in Spain and the associated diagnostic and therapeutic problems are also described. Read More

    Effect of honeybee stinger and its microstructured barbs on insertion and pull force.
    J Mech Behav Biomed Mater 2017 Apr 25;68:173-179. Epub 2017 Jan 25.
    Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, Sun Yat-Sen University, Guangzhou 510006, PR China. Electronic address:
    Worker honeybee is well-known for its stinger with microscopic backward-facing barbs for self-defense. The natural geometry of the stinger enables painless penetration and adhesion in the human skin to deliver poison. In this study, Apis cerana worker honeybee stinger and acupuncture microneedle (as a barbless stinger) were characterized by Scanning Electron Microscope (SEM). Read More

    Longitudinal Study of Pediatric Urticaria Pigmentosa.
    Pediatr Dermatol 2017 Mar 30;34(2):144-149. Epub 2017 Jan 30.
    Department of Dermatology, Mayo Clinic Health System, Eau Claire, Wisconsin.
    Background/objectives: Urticaria pigmentosa (UP) is the most common form of mastocytosis in children and is associated with systemic signs, symptoms, and triggers. To our knowledge, the effect of UP on children's quality of life has not been studied. The objective of the current study was to characterize the natural history, triggers, and complications of pediatric UP, identify prognostic indicators, and determine its effect on quality of life. Read More

    Hymenoptera Venom Allergy. A closer collaboration is needed between allergists and emergency physicians.
    Eur Ann Allergy Clin Immunol 2017 Jan;49(1):15-17
    Allergy Unit, Loreto Crispi Hospital, ASL Napoli 1 - Centro, Naples, Italy. E-mail:
    Background. Hymenoptera stings are sometimes fatal in venom-allergic patients. Fatalities mostly occur in previously stung subjects, especially those with a history of systemic reactions, and could be avoided if patients were properly informed of the existence of a prevention strategy for insect stings, referred to an allergy follow-up and prescribed auto-injectable epinephrine and/or venom-specific immunotherapy (VIT). Read More

    Allergen immunotherapy for insect venom allergy: a systematic review and meta-analysis.
    Allergy 2017 Mar 25;72(3):342-365. Epub 2017 Jan 25.
    Allergy and Respiratory Research Group, The University of Edinburgh, Edinburgh, UK.
    Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines on Allergen Immunotherapy (AIT) for the management of insect venom allergy. To inform this process, we sought to assess the effectiveness, cost-effectiveness and safety of AIT in the management of insect venom allergy.

    Methods: We undertook a systematic review, which involved searching 15 international biomedical databases for published and unpublished evidence. Read More

    Pre-hospital treatment of bee and wasp induced anaphylactic reactions: a retrospective study.
    Scand J Trauma Resusc Emerg Med 2017 Jan 14;25(1). Epub 2017 Jan 14.
    Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital, Sdr. Boulevard 29, Odense, DK-5000, Denmark.
    Background: Bee and wasp stings are among the most common triggers of anaphylaxis in adults representing around 20% of fatal anaphylaxis from any cause. Data of pre-hospital treatment of bee and wasp induced anaphylactic reactions are sparse. This study aimed to estimate the incidence of bee and wasp induced anaphylactic reactions, the severity of the reactions and to correlate the pre-hospital treatment with the severity of the anaphylactic reaction. Read More

    Do Quiescence and Wasp Venom-Induced Lethargy Share Common Neuronal Mechanisms in Cockroaches?
    PLoS One 2017 3;12(1):e0168032. Epub 2017 Jan 3.
    Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    The escape behavior of a cockroach may not occur when it is either in a quiescent state or after being stung by the jewel wasp (Ampulex compressa). In the present paper, we show that quiescence is an innate lethargic state during which the cockroach is less responsive to external stimuli. The neuronal mechanism of such a state is poorly understood. Read More

    Mechanisms Underlying the Nonconsumptive Effects of Parasitoid Wasps on Aphids.
    Environ Entomol 2017 02;46(1):75-83
    Division of Plant Sciences, University of Missouri, 1-31 Agriculture Bldg., Columbia, MO 65211
    Natural enemies need not consume herbivores to suppress herbivore populations. Behavioral interactions can adversely impact herbivore fitness from reduced time feeding, investment in defense, or injury from failed attacks. The importance of such "nonconsumptive effects" for herbivore suppression may vary across species based on the specificity and intensity of the herbivore defensive response. Read More

    Transient Coagulopathy Due to Wasp Sting: A Case Report.
    J Emerg Med 2017 Apr 18;52(4):e115-e116. Epub 2016 Dec 18.
    Emergency Department, Tan Tock Seng Hospital, Singapore.
    Background: Insect venom anaphylaxis is a potentially life-threatening disorder. Transient coagulopathy in insect venom anaphylaxis is a rare phenomenon.

    Case Report: A 41-year-old man presented to the Emergency Department (ED) with hypotension after a run in a park. Read More

    Insect Venom Immunotherapy: Analysis of the Safety and Tolerance of 3 Buildup Protocols Frequently Used in Spain.
    J Investig Allergol Clin Immunol 2016 ;26(6):366-373
    Hymenoptera Allergy Committee of the SEAIC
    Introduction: Hymenoptera venom immunotherapy (VIT) is an effective treatment but not one devoid of risk, as both local and systemic adverse reactions may occur, especially in the initial phases. We compared the tolerance to 3 VIT buildup protocols and analyzed risk factors associated with adverse reactions during this phase.

    Materials And Methods: We enrolled 165 patients divided into 3 groups based on the buildup protocol used (3, 4, and 9 weeks). Read More

    IgE-Api m 4 Is Useful for Identifying a Particular Phenotype of Bee Venom Allergy.
    J Investig Allergol Clin Immunol 2016;26(6):355-361
    Maimonides Biomedical Research Institute of Cordoba (IMIBIC).
    Background And Objective: Different clinical behaviors have been identified in patients allergic to bee venom. Compound-resolved diagnosis could be an appropriate tool for investigating these differences. The aims of this study were to analyze whether specific IgE to Api m 4 (sIgE-Api m 4) can identify a particular kind of bee venom allergy and to describe response to bee venom immunotherapy (bVIT). Read More

    [Mastocytosis : Clinical aspects, diagnostics, therapy].
    Hautarzt 2017 Jan;68(1):67-75
    Mastozytosezentrum der Klinik für Dermatologie, Venerologie, Allergologie, Universitätsmedizin Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Deutschland.
    Mastocytosis is a rare, almost exclusively sporadically occurring disease involving an increase in clonal tissue mast cells. The disease spectrum is heterogenous, ranging from isolated skin lesions with a normal life expectancy to rare, aggressive forms with very poor prognosis. Children are often affected. Read More

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