J Am Coll Cardiol 2018 02;71(5):513-523
British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom; Edinburgh Imaging Facility, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom; National Health Service Lothian, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.
Background: Fluorine-18-sodium fluoride (F-NaF) uptake is a marker of active vascular calcification associated with high-risk atherosclerotic plaque.
Objectives: In patients with abdominal aortic aneurysm (AAA), the authors assessed whether F-NaF positron emission tomography (PET) and computed tomography (CT) predicts AAA growth and clinical outcomes.
Methods: In prospective case-control (n = 20 per group) and longitudinal cohort (n = 72) studies, patients with AAA (aortic diameter >40 mm) and control subjects (aortic diameter <30 mm) underwent abdominal ultrasound, F-NaF PET-CT, CT angiography, and calcium scoring. Read More