307 results match your criteria Hydroa Vacciniforme


Novel mutations of STXBP2 and LYST associated with adult haemophagocytic lymphohistiocytosis with Epstein-Barr virus infection: a case report.

BMC Med Genet 2019 Feb 19;20(1):34. Epub 2019 Feb 19.

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.

Background: Haemophagocytic lymphohistiocytosis is a life-threatening disease resulting from primary or secondary hyper-inflammatory disorders. The typical symptoms include persistent fever, splenomegaly, cytopenia and significant elevation of serum ferritin.

Case Presentation: We report a 30-year-old Chinese female patient who was diagnosed with chronic active Epstein-Barr virus infection more than 9 months prior and has since been presenting with cutaneous lymphoproliferative disorders mimicking hydroa vacciniforme and subsequent haemophagocytic lymphohistiocytosis. Read More

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http://dx.doi.org/10.1186/s12881-019-0765-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379998PMC
February 2019
1 Read
2.083 Impact Factor

Overview of EBV-Associated T/NK-Cell Lymphoproliferative Diseases.

Front Pediatr 2018 4;6:417. Epub 2019 Jan 4.

Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.

Epstein-Barr virus-associated T/natural killer-cell lymphoproliferative diseases (EBV-T/NK-LPDs) are a group of rare diseases resulting from ectopic infection of T or natural killer (NK) lymphocytes with Epstein-Barr virus (EBV). EBV-T/NK-LPDs include chronic active EBV infection, EBV-associated hemophagocytic lymphohistiocytosis, hydroa vacciniforme-like lymphoproliferative disease, and severe mosquito bite allergy. Extra-nodal NK/T-cell lymphoma-nasal type and aggressive NK-cell leukemia can also be included in this broad spectrum. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00417/
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http://dx.doi.org/10.3389/fped.2018.00417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328478PMC
January 2019
5 Reads

Hydroa vacciniforme-like lymphoproliferative disorder: Clinicopathologic study of 41 cases.

J Am Acad Dermatol 2019 Jan 14. Epub 2019 Jan 14.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 15 of Changlexi Road, Xian 710032, China. Electronic address:

Background: Hydroa vacciniforme-like lymphoproliferative disorder (HVLLPD) is a rare Epstein-Barr virus (EBV)-related disease usually found in East Asians and Latin Americans.

Objective: To report the characteristics of HVLLPD in Chinese patients.

Methods: Retrospective analysis of HVLLPD patients from a single institute. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622193008
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http://dx.doi.org/10.1016/j.jaad.2019.01.011DOI Listing
January 2019
5 Reads

Ocular manifestations of hydroa vacciniforme in a Black child.

Eur J Ophthalmol 2018 Dec 26:1120672118820518. Epub 2018 Dec 26.

1 University of the Witwatersrand, Johannesburg, Johannesburg, South Africa.

Purpose:: To report the clinical presentation (systemic and ocular) of hydroa vacciniforme in a Black South African child.

Methods:: Case report.

Results:: A 14-year-old Black boy was seen at the corneal service with cutaneous erosions, varioliform scarring, corneal scarring, cicatricial conjunctivitis and central crystalline corneal opacity. Read More

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http://journals.sagepub.com/doi/10.1177/1120672118820518
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http://dx.doi.org/10.1177/1120672118820518DOI Listing
December 2018
2 Reads

Clinicopathological analysis of the hydroa vacciniforme-like lymphoproliferative disorder with natural killer cell phenotype compared with cutaneous natural killer T-cell lymphoma.

Exp Ther Med 2018 Dec 19;16(6):4772-4778. Epub 2018 Sep 19.

Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) is defined as a distinctive clinicopathological type of cutaneous lymphoma and a subset of patients with this disease exhibit the natural killer (NK)-cell phenotype. The HVLPD-NK cell phenotype may be difficult to distinguish from cutaneous natural killer T-cell lymphoma (CNKTL), as these two diseases share similar immunophenotypic markers. Therefore, the aim of the present study was to analyze the clinicopathological features of this rare disease and compare these features with those of CNKTL. Read More

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http://dx.doi.org/10.3892/etm.2018.6768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257548PMC
December 2018

Cytologic Analysis of Epstein-Barr Virus-Associated T/Natural Killer-Cell Lymphoproliferative Diseases.

Authors:
Akihiro Yachie

Front Pediatr 2018 16;6:327. Epub 2018 Nov 16.

Department of Pediatrics, School of Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.

Rapid, precise diagnosis of Epstein-Barr virus-associated T lymphocyte or natural killer cell lymphoproliferative diseases is clinically important to prevent disease progression and avoid fatal outcomes for patients. In addition to detecting increased copy numbers of Epstein-Barr virus, identification of the lymphocyte subpopulation targeted by the virus infection is crucial to reaching the final diagnosis. However, these procedures are laborious and require large amounts of sample. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00327/
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http://dx.doi.org/10.3389/fped.2018.00327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250743PMC
November 2018
10 Reads

Epstein-Barr virus and skin.

An Bras Dermatol 2018 Nov/Dec;93(6):786-799

Hospital Cayetano Heredia, Lima, Peru.

Epstein-Barr virus is a DNA virus infecting human beings and could affect 90% of human population. It is crucial to take in account that in Latin America, unlike what happens in developed countries, the exposure to the virus is very early and therefore people have a much longer interaction with the virus. The virus is related to many diseases, mainly the oncological ones, and when the onset is in cutaneous tissue, it can present many clinical variants, as well acute as chronic ones. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20187021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256212PMC
February 2019
10 Reads

Haemorrhagic vesicles and varioliform scarring: consider photosensitivity.

Arch Dis Child 2018 Nov 13. Epub 2018 Nov 13.

Department of Dermatology, Salford Royal NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1136/archdischild-2018-316272DOI Listing
November 2018

Epstein-Barr Virus-Positive T/NK-Cell Lymphoproliferative Diseases in Chinese Mainland.

Front Pediatr 2018 9;6:289. Epub 2018 Oct 9.

Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders (EBV T/NK LPD) encompass a heterogeneous group of disorders, including chronic active Epstein-Barr virus infection (CAEBV), Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH), systemic EBV T-cell lymphoma of childhood and hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) and so on, predominantly affecting children and young adults with high mortality. Patients with EBV T/NK LPD have overlapping clinical symptoms as well as histologic and immunophenotypic features. In this review, we summarized the clinical features of EBV T/NK LPD in Chinese patients from the published articles. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00289/
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http://dx.doi.org/10.3389/fped.2018.00289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189562PMC
October 2018
7 Reads

[Clinical and pathological features of 13 children with Epstein-Barr virus-positive lymphoproliferative disease].

Zhonghua Er Ke Za Zhi 2018 Oct;56(10):759-764

Department of Infectious Disease, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China.

To summarize the clinical characteristics, virological and histopathological features, clinical outcome of Epstein-Barr virus-positive lymphoproliferative disease (EBV(+)LPD) in children. The clinical and follow-up data of 13 children histopathologically diagnosed as EBV(+)LPD in the Department of Infectious Disease of Beijing Children's Hospital between January 2011 and December 2016 were summarized. Of the 13 patients, 5 were males and 8 females. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.10.008DOI Listing
October 2018
1 Read

Cutaneous Lymphoproliferative Disorders: What's New in the Revised 4th Edition of the World Health Organization (WHO) Classification of Lymphoid Neoplasms.

Authors:
Uma Sundram

Adv Anat Pathol 2019 Mar;26(2):93-113

Department of Anatomic Pathology, Oakland University William Beaumont School of Medicine and Beaumont Health Systems, Royal Oak, MI.

Cutaneous lymphoproliferative disorders remain a challenging aspect of dermatopathology, in part due to the rarity of the entities and extreme variability in clinical outcomes. Although many of the entities remain unchanged, the approach to some of them has changed in the new 2016 classification scheme of the World Health Organization. Chief among these are Epstein-Barr virus-associated lymphoproliferative disorders such as Epstein-Barr virus-associated mucocutaneous ulcer and hydroa vacciniforme-like lymphoproliferative disorder, primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma, primary cutaneous acral CD8+ T-cell lymphoma, primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder, and breast implant-associated anaplastic large cell lymphoma. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000208DOI Listing
March 2019
19 Reads

Comparative Study of the Clinical Pathology, Immunophenotype, Epstein-Barr Virus Infection Status, and Gene Rearrangements in Adult and Child Patients With Hydroa Vacciniforme-Like Lymphoproliferative Disorder.

Am J Dermatopathol 2019 Jan;41(1):7-15

Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) is a rare Epstein-Barr virus (EBV)-associated lymphoma that mainly affects children.

Objectives: To examine the similarities and differences in the clinical pathological features, EBV infection status, and gene rearrangements in adults and children patients with HVLPD.

Methods: We compared the clinical manifestations, histopathology, immunophenotypical features, EBV infection status, and T-cell receptor gene rearrangements in the adult and children HVLPD groups. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001229DOI Listing
January 2019
4 Reads

Photocontact Dermatitis and Its Clinical Mimics: an Overview for the Allergist.

Clin Rev Allergy Immunol 2019 Feb;56(1):32-40

Department of Dermatology, The University of Texas Southwestern, 5323 Harry Hines Blvd, Dallas, TX, 75390-9069, USA.

Photo-contact dermatitis (PCD) describes the adverse cutaneous reaction that occurs in some patients as a result of simultaneous exposure to a contactant and to light. PCD can be subdivided into photo-allergic and photo-irritant dermatitis depending on whether the contactant respectively invokes an allergic or irritant reaction. Photo-irritant reactions are commonly caused by plants, psoralens, and medications taken internally, whereas photo-allergic reactions are commonly caused by sunscreens and topical nonsteroidal anti-inflammatory medications. Read More

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http://dx.doi.org/10.1007/s12016-018-8696-xDOI Listing
February 2019
26 Reads

Hydroa vacciniforme-like lymphoproliferative disorder in an elderly Chinese patient and a literature review of adult cases.

Int J Dermatol 2018 Nov 21;57(11):1283-1292. Epub 2018 Jun 21.

National Skin Centre, Singapore, Singapore.

Hydroa vaccinforme-like lymphoproliferative disorder (HVLPD) is a rare T-cell lymphoproliferative disorder driven by the Epstein-Barr Virus (EBV). It was initially designated under the 2008 WHO classification of tumors of hematopoietic and lymphoid tissues as a distinct entity but has been recently reclassified as a lymphoproliferative disorder under the 2016 revision of the 2008 WHO classification of lymphoid malignancies. HVLPD mainly affects Asian, Central, and South American children. Read More

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http://dx.doi.org/10.1111/ijd.14050DOI Listing
November 2018
2 Reads

Adult-onset hydroa vacciniforme-like lymphoma in a long-term resident of the United States.

JAAD Case Rep 2018 May 31;4(4):314-317. Epub 2018 Mar 31.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1016/j.jdcr.2017.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911818PMC
May 2018
1 Read

Hydroa vacciniforme-like cutaneous T-cell lymphoma in a child: A case report.

Medicine (Baltimore) 2018 04;97(15):e0319

Department of Pediatrics, West China Second University Hospital.

Rationale: Hydroa vacciniforme (HV)-like T-cell lymphoma is a rare malignancy in childhood associated with Epstein-Barr virus infection.

Patient Concerns: A 6-year old girl presented with complaint of 3-year history of recurrent skin lesions, 3 months of fever accompanied by cough for 8 days.

Diagnoses: Skin biopsy revealed a HV-like lymphoma presentation and positive signals of EBER were detected by in situ hybridization. Read More

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http://dx.doi.org/10.1097/MD.0000000000010319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908608PMC
April 2018
8 Reads

Hydroa Vacciniforme-Like Cutaneous T-Cell Lymphoma in an Adult Presenting With Facial Edema and Recurrent Oral Ulceration.

Am J Dermatopathol 2018 03;40(3):227-229

Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.

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http://dx.doi.org/10.1097/DAD.0000000000000845DOI Listing
March 2018
3 Reads

GATA2 Deficiency and Epstein-Barr Virus Disease.

Authors:
Jeffrey I Cohen

Front Immunol 2017 22;8:1869. Epub 2017 Dec 22.

Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

GATA2 is a transcription factor that binds to the promoter of hematopoietic genes. Mutations in one copy of the gene are associated with haploinsufficiency and reduced levels of protein. This results in reduced numbers of several cell types important for immune surveillance including dendritic cells, monocytes, CD4, and NK cells, as well as impaired NK cell function. Read More

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http://dx.doi.org/10.3389/fimmu.2017.01869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770745PMC
December 2017
4 Reads

Characterization of skin blister fluids from children with Epstein-Barr virus-associated lymphoproliferative disease.

J Dermatol 2018 Apr 20;45(4):444-449. Epub 2018 Jan 20.

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

Epstein-Barr virus (EBV)-associated T- or natural killer (NK)-cell lymphoproliferative disease (LPD) is a heterogeneous group of disorders characterized by chronic proliferation of EBV-infected lymphocytes. Patients may present with severe skin manifestations, including hypersensitivity to mosquito bites (HMB) and hydroa vacciniforme (HV)-like eruption, which are characterized by blister formation and necrotic ulceration. Skin biopsy specimens show inflammatory reactions comprising EBV-infected lymphocytes. Read More

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http://dx.doi.org/10.1111/1346-8138.14226DOI Listing
April 2018
8 Reads

A distinct subtype of Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorder: adult patients with chronic active Epstein-Barr virus infection-like features.

Haematologica 2018 Jun 14;103(6):1018-1028. Epub 2017 Dec 14.

Department of Pathology, Kurume University School of Medicine, Niigata University, Japan.

The characteristics of adult patients with chronic active Epstein-Barr virus infection are poorly recognized, hindering early diagnosis and an improved prognosis. We studied 54 patients with adult-onset chronic active Epstein-Barr virus infection diagnosed between 2005 and 2015. Adult onset was defined as an estimated age of onset of 15 years or older. Read More

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http://dx.doi.org/10.3324/haematol.2017.174177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058795PMC
June 2018
26 Reads

Adult-onset Hydroa Vacciniforme: A Rare Occurrence or a Lymphoma Premonition?

Indian Dermatol Online J 2017 Nov-Dec;8(6):490-491

Department of Dermatology, Pt BD Sharma PGIMS, University of Health Sciences, Rohtak, Haryana, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_286_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707847PMC
December 2017
7 Reads

Primary cutaneous T-cell lymphoma: experience from the Peruvian National Cancer Institute.

An Bras Dermatol 2017 Sep-Oct;92(5):649-654

Medical Oncology Service, Instituto Nacional de Enfermedades Neoplásicas (INEN) - Surquillo, Peru.

Background: Primary cutaneous T-cell lymphomas constitute a heterogeneous and rare group of diseases with regional particularities in Latin America.

Objective: To determine the clinicopathological features, relative frequency and survival among patients from a Peruvian institution.

Methods: Primary cutaneous T-cell lymphomas were defined based on the absence of extracutaneous disease at diagnosis. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20176825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674697PMC
February 2018
39 Reads

Epstein-Barr Virus-Associated Vesiculopapular Eruption on the Face of a Patient with Natural Killer T Cell Lymphoma.

Ann Dermatol 2017 Oct 25;29(5):618-620. Epub 2017 Aug 25.

Department of Dermatology, Seoul National University Hospital, Seoul, Korea.

Unlike typical hydroa vacciniforme (HV), Epstein-Barr virus (EBV)-associated HV-like eruption is more variable in its clinical manifestations. In some patients, progression to lymphoma or leukemia has been reported, which are characterized by the T-cell immunophenotype. Here, we report the first Korean case of EBV-associated vesiculopapular eruption on the face of a patient with natural killer (NK)/T cell lymphoma. Read More

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http://dx.doi.org/10.5021/ad.2017.29.5.618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597657PMC
October 2017
28 Reads

Recurrent scarring papulovesicular lesions on sun-exposed skin in a 22-year-old man.

J Am Acad Dermatol 2018 03 28;78(3):637-642. Epub 2017 Sep 28.

Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:

KEY TEACHING POINTS. Read More

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http://dx.doi.org/10.1016/j.jaad.2017.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815928PMC
March 2018
20 Reads
4.450 Impact Factor

Two cases of hydroa vacciniforme-like lymphoproliferative disease controlled by anti-inflammatory agents.

Photodermatol Photoimmunol Photomed 2017 09 20;33(5):287-290. Epub 2017 Jun 20.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1111/phpp.12318DOI Listing
September 2017
35 Reads

Epstein-Barr Virus-associated Lymphoproliferative Disorders in the Skin.

Authors:
John R Goodlad

Surg Pathol Clin 2017 Jun 18;10(2):429-453. Epub 2017 Mar 18.

Haematological Malignancy Diagnostic Services (HMDS), Level 3, Bexley Wing, St James's University Hospital, Leeds LS9 7TF, UK. Electronic address:

Epstein-Barr virus (EBV)-associated lymphoproliferations involving the skin are a rare but important group of diseases with a broad spectrum of behavior, ranging from self-limiting spontaneously resolving disorders to highly aggressive malignancies. They may be of B, T, or natural killer (NK) cell type and include EBV-positive mucocutaneous ulcer, lymphomatoid granulomatosis, EBV-positive diffuse large B-cell lymphoma, hydroa vacciniforme-like lymphoproliferative disorder, and extranodal NK/T-cell lymphoma of nasal type. Recognition and distinction of these entities is important in view of their differing prognoses and treatments. Read More

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http://dx.doi.org/10.1016/j.path.2017.01.001DOI Listing
June 2017
29 Reads

Hydroa Vacciniforme-Like Lymphoma in Tibetan Children: 2 Cases and a Literature Review.

Am J Dermatopathol 2018 May;40(5):358-361

Department of Dermatovenereology, West China Hospital, Sichuan University, Sichuan, China.

Hydroa vacciniforme-like lymphoma shows a marked predilection for the pediatric population, especially in Latin America and Asia. Here, we present 2 pediatric patients from Tibet of China, which is the first report from this area. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000880DOI Listing
May 2018
12 Reads

Hydroa Vacciniforme-Like T-Cell Lymphoma: A Further Brazilian Case.

Am J Dermatopathol 2018 Mar;40(3):201-204

Hydroa vacciniforme (HV)-like lymphoma is a rare, usually fatal Epstein-Barr virus-driven lymphoproliferative disease affecting children from Asia, Mexico, and South America. Cutaneous manifestations imitate HV, a benign photodermatosis in which systemic symptoms are not observed, and spontaneous regression occurs later in adolescence or young adulthood. We report a case of HV-like lymphoma in a 12-year-old girl, descendent from an ancient Amazon indigenous tribe that, as far as we know, represents the second Brazilian case ever reported in the medical literature. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000846DOI Listing
March 2018
17 Reads

How we treat chronic active Epstein-Barr virus infection.

Int J Hematol 2017 Apr 16;105(4):406-418. Epub 2017 Feb 16.

Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo, Izumi City, Osaka, 594-1101, Japan.

Chronic active Epstein-Barr virus infection (CAEBV) is a prototype of the EBV-associated T- or NK-cell lymphoproliferative diseases, which also include hypersensitivity to mosquito bites and severe-type hydroavacciniforme. The manifestations of CAEBV are often self-limiting with minimum supportive care or only prednisolone and cyclosporine A with or without etoposide. However, allogeneic hematopoietic stem cell transplantation (HSCT) is the only cure, without which patients with CAEBV die within several years. Read More

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http://dx.doi.org/10.1007/s12185-017-2192-6DOI Listing
April 2017
45 Reads

[The understanding of Epstein-Barr virus associated lymphoproliferative disorder].

Zhonghua Bing Li Xue Za Zhi 2016 Dec;45(12):817-821

Department of Pathology, Beijing Friendship Hospital Capital Medical University, Beijing 100050, China.

In recent years, there are increasing articles concerning Epstein-Barr virus associated lymphoproliferative disorder (EBV+ LPD), and the name of EBV+ LPD is used widely. However, the meaning of EBV+ LPD used is not the same, which triggered confusion of the understanding and obstacles of the communication. In order to solve this problem. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2016.12.001DOI Listing
December 2016
6 Reads

Cutaneous EBV-related lymphoproliferative disorders.

Semin Diagn Pathol 2017 Jan 7;34(1):60-75. Epub 2016 Dec 7.

Hematopathology, National Cancer Institute (NCI), Bethesda, MD, USA.

This article will focus on the cutaneous lymphoproliferative disorders associated with EBV, with an emphasis on the upcoming changes in the revised 4th Edition of the WHO classification of tumors of the hematopoietic system, many of which deal with cutaneous disorders derived from NK-cells or T-cells. Extranodal NK/T-cell lymphoma usually presents in the upper aerodigestive tract, but can involve the skin secondarily. EBV-associated T- and NK-cell lymphoproliferative disorders (LPD) in the pediatric age group include the systemic diseases, chronic active EBV infection (CAEBV) and systemic EBV+ T-cell lymphoma of childhood. Read More

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http://dx.doi.org/10.1053/j.semdp.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340146PMC
January 2017
35 Reads

Photodermatoses: Kids are not just little people.

Clin Dermatol 2016 Nov - Dec;34(6):724-735. Epub 2016 Jul 12.

University of Connecticut School of Medicine, Department of Dermatology, Farmington, CT.

Photodermatoses are a group of skin disorders caused by abnormal reaction to ultraviolet radiation. Photodermatoses are divided into four groups: (1) immunologically mediated photodermatoses; (2) chemical- and drug-induced photodermatoses; (3) photoaggravated dermatoses; and (4) hereditary photodermatoses. This contribution discusses differences in the approach and diagnosis of pediatric and adult patients with suspected photodermatoses, focusing on immunologically mediated photodermatoses and chemical- and drug-induced photodermatoses. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2016.07.007DOI Listing
June 2017
12 Reads

Hydroa vacciniforme-like lymphoma.

Authors:
J Qiao H Fang

QJM 2016 Oct 9;109(10):697-698. Epub 2016 Aug 9.

Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou 310003, Zhejiang, People's Republic of China. email:

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http://dx.doi.org/10.1093/qjmed/hcw137DOI Listing
October 2016
6 Reads

Differential diagnosis of herpetiform vesicles by a non-invasive, molecular method using crusts or blister roofs: Sensitivity, specificity and likelihood ratio.

J Dermatol Sci 2016 Dec 3;84(3):358-359. Epub 2016 Oct 3.

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 700-8558, Okayama, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2016.10.002DOI Listing
December 2016
13 Reads

Hydroa vacciniforme and hydroa vacciniforme-like T-cell lymphoma: an uncommon event for transformation.

J Cutan Pathol 2016 Dec 9;43(12):1102-1111. Epub 2016 Sep 9.

Department of Dermatology, College of Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan.

Background: Hydroa vacciniforme (HV) is associated with Epstein-Barr virus (EBV) infection and a risk of transformation to lymphoma.

Methods: We retrospectively analyzed six HV cases for EBV association and transformation to HV-like T-cell lymphoma. Clinicopathologic features were reviewed and cases were assessed for EBV-encoded RNA (EBER) by in situ hybridization, double staining with immunohistochemistry and EBER and for T-cell clonality. Read More

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http://dx.doi.org/10.1111/cup.12801DOI Listing
December 2016
38 Reads

Hydroavacciniforme on a dark skin with mucosal involvement.

Pan Afr Med J 2016 9;23:71. Epub 2016 Mar 9.

Hospital University Hassan II, Department of Dermatology, Faculty of Medicine, Fez, Morocco.

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http://dx.doi.org/10.11604/pamj.2016.23.71.9199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862798PMC
February 2017
14 Reads

Association of GATA2 Deficiency With Severe Primary Epstein-Barr Virus (EBV) Infection and EBV-associated Cancers.

Clin Infect Dis 2016 07 11;63(1):41-7. Epub 2016 May 11.

Laboratorie of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases.

Background: Most patients infected with Epstein-Barr virus (EBV) are asymptomatic, have nonspecific symptoms, or have self-limiting infectious mononucleosis. EBV, however, may result in severe primary disease or cancer.

Methods: We report EBV diseases associated with GATA2 deficiency at one institution and describe the hematology, virology, and cytokine findings. Read More

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http://dx.doi.org/10.1093/cid/ciw160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901862PMC
July 2016
19 Reads

Clinicopathological categorization of Epstein-Barr virus-positive T/NK-cell lymphoproliferative disease: an analysis of 42 cases with an emphasis on prognostic implications.

Leuk Lymphoma 2017 01 9;58(1):53-63. Epub 2016 May 9.

a Department of Pathology , Seoul National University Hospital, Seoul National University College of Medicine , Seoul , South Korea.

Epstein-Barr virus-positive T/NK-cell lymphoproliferative diseases (EBV-T/NK-LPDs) include several overlapping EBV-related conditions with variably aggressive courses. For prognostic categorization, we retrospectively analyzed 42 EBV-T/NK-LPD cases. Male (79% [33/42]), young (≤40 years; 83% [35/42]) patients and T-cell lineage (81% [34/42]; CD8/CD4 = 1. Read More

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http://dx.doi.org/10.1080/10428194.2016.1179297DOI Listing
January 2017
32 Reads

Atypical hydroa vacciniforme mimicking dermatomyositis: A case report in a Lebanese girl.

JAAD Case Rep 2015 Mar 6;1(2):63-5. Epub 2015 Feb 6.

Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.

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http://dx.doi.org/10.1016/j.jdcr.2015.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802539PMC
March 2015
22 Reads

Epstein-Barr virus reactivation is induced, but abortive, in cutaneous lesions of systemic hydroa vacciniforme and hypersensitivity to mosquito bites.

J Dermatol Sci 2016 Jun 5;82(3):153-9. Epub 2016 Mar 5.

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. Electronic address:

Background: Epstein-Barr virus (EBV)-associated T/natural killer (NK)-lymphoproliferative disorders (LPDs) include hydroa vacciniforme (HV) and hypersensitivity to mosquito bites (HMB). The pathomechanisms of these diseases are still unclear.

Objective: To understand the inflammatory process, we examined EBV reactivation markers, BZLF1 and BDRF1 mRNA in the tissue and blood from patients with EBV-associated T/NK-LPDs. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2016.03.001DOI Listing
June 2016
20 Reads

Mature T- and NK-cell non-Hodgkin lymphoma in children and young adolescents.

Br J Haematol 2016 05 15;173(4):573-81. Epub 2016 Mar 15.

Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, USA.

Mature T/Natural killer (NK)-cell neoplasms of children and the young adolescent population exhibit higher prevalence in Central and South American and Asian populations and many are associated with Epstein-Barr virus (EBV). They are represented in large part by extranodal T/NK cell lymphomas- nasal-type or extra nasal-type, chronic lymphoproliferative disorders of T/NK cells or chronic active EBV disease, systemic EBV-positive lymphoproliferative disorders of childhood, hydroa vacciniforme-like lymphoma, hepatosplenic T-cell lymphoma and primary cutaneous gamma/delta T-cell lymphoma among others. Many T/NK cell neoplasms in this age group are derived from cells of the innate immune system, in contrast to adults where they are predominantly from the adaptive immune system. Read More

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http://dx.doi.org/10.1111/bjh.14044DOI Listing
May 2016
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Marked Increase of Circulating Double-Negative γδ T Cells in a Patient With Hydroa Vacciniforme-Like Lymphoma.

Ann Lab Med 2016 May;36(3):268-70

Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3343/alm.2016.36.3.268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773271PMC
May 2016
3 Reads

Hydroa Vacciniforme-Like EBV-Positive Cutaneous T-Cell Lymphoma, First Report of 2 Cases in Ecuador.

Am J Dermatopathol 2016 May;38(5):e57-9

Servicio de Patología, Hospital Metropolitano, Quito, Ecuador.

Hydroa vacciniforme-like cutaneous lymphoma is a very rare Epstein-Barr virus positive peripheral T-cell lymphoma affecting Asian and Hispanic children and young adults with a defective cytotoxic immune response to EBV predisposing to the development of the disease. We report on 2 Ecuadorian patients with papulovesicular and ulcerated crusted lesions on the face, upper and lower extremities and abdomen, with aggressive clinical course and, in one case, a fatal outcome. The histological and molecular profiles (immunohistochemistry and in situ hybridization) established a diagnosis of hydroa vacciniforme-like Epstein-Barr virus-encoded small RNAs + cutaneous T-cell lymphoma in both cases. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000485DOI Listing
May 2016
9 Reads

Progressive scarring facial lesions in a boy.

Clin Case Rep 2016 Feb 6;4(2):120-2. Epub 2015 Dec 6.

Dermatology Service KK Women's & Children's Hospital Singapore Singapore.

Hydroa vacciniforme is a photosensitivity disorder characterized by the childhood onset of necrotic vesiculopapules on exposed areas. We present a case of a 10-year-old boy with a 1-year history of papular lesions over his face. In this report, we discuss the in-depth histology of hydroa vacciniforme, and the management options. Read More

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http://dx.doi.org/10.1002/ccr3.443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736522PMC
February 2016
4 Reads

Hydroa Vacciniforme-Like Eruption Associated with Epstein-Barr Virus Infection in an Older Adult.

Ann Dermatol 2015 Dec 7;27(6):789-91. Epub 2015 Dec 7.

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.5021/ad.2015.27.6.789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695445PMC
December 2015
4 Reads

Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea.

Bol Med Hosp Infant Mex 2016 Jan - Feb;73(1):10-17. Epub 2016 Feb 1.

Department of Pathology, Samsung Medical Center, Sungkyunkwan University, Seoul, Korea. Electronic address:

Background: Chronic active EBV infection (CAEBV) of T-cell or NK-cell type is an EBV+ polyclonal, oligoclonal or often monoclonal lymphoproliferative disorder (LPD) recognized as representing the spectrum of EBV-associated T-cell and NK-cell LPD with different clinical presentations; one systemic and two cutaneous disorders including hydroa vacciniforme-like T-cell LPD and mosquito bite hypersensitivity. The systemic form of the disease is characterized by fever, persistent hepatitis, hepatosplenomegaly and lymphadenopathy, which shows varying degrees of clinical severity depending on the immune response of the host and the EBV viral load.

Case Reports: We described the clinicopathological findings of two children with CAEBV with a brief review of the literature. Read More

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http://dx.doi.org/10.1016/j.bmhimx.2015.12.003DOI Listing
February 2016
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Clinicopathologic Features of Hydroa Vacciniforme-Like Lymphoma: A Series of 9 Patients.

Am J Dermatopathol 2016 Jan;38(1):20-5

*Centre for Dermatology & Dermatopathology and School of Medicine, Universidad Nacional Autónoma de México/Hospital General de México "Eduardo Liceaga," México, DF, Mexico; and †Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria.

Hydroa vacciniforme-like lymphoma is a recently recognized cutaneous T-cell lymphoma associated with Epstein-Barr virus. The disease is observed in children of Latin American or Asian ethnicity. The authors report the clinical, histopathological, and immunophenotypical features of 9 new Mexican patients (M:F = 2:1; mean age, 14. Read More

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http://pdfs.journals.lww.com/amjdermatopathology/9000/00000/
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http://dx.doi.org/10.1097/DAD.0000000000000385DOI Listing
January 2016
10 Reads

Chronic active Epstein-Barr virus infection with cutaneous and sinus lymphoproliferation in a white female patient with 25 years' follow-up: an original case report.

Br J Dermatol 2015 Nov 8;173(5):1266-70. Epub 2015 Sep 8.

Department of Dermatology, CHU Caen, Université de Caen Basse Normandie, 14000, Caen, France.

Chronic active Epstein-Barr virus infection (CAEBV) is characterized by chronic infectious mononucleosis-like symptoms associated with very high viral load, as assessed by quantitative polymerase chain reaction. We present an unusual case in a French woman who was followed up over 25 years with cutaneous and sinus lymphoproliferation. This white woman presented with a long history of recurrent cutaneous necrotic papules of the skin, which started during childhood and healed spontaneously with depressed scars. Read More

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http://dx.doi.org/10.1111/bjd.14014DOI Listing
November 2015
3 Reads