343 results match your criteria Hydroa Vacciniforme


Hydroa vacciniforme-like lymphoproliferative disorder: A clinicopathological, immunohistochemical, and prognostic study of 24 cases in China.

J Dermatol 2021 May 13. Epub 2021 May 13.

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Hydroa vacciniforme-like lymphoproliferative disorder (HV-LPD) is a rare cutaneous disease associated with Epstein-Barr virus infection. We retrospectively analyzed the clinical presentation, histopathological characteristics, and prognostic study of HV-LPD in 24 Chinese patients. All patients presented with recurrent papulovesicular and necrotic eruptions on the face, neck, and extremities, with 11 showing systemic symptoms. Read More

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Hydroa vacciniforme-like lymphoproliferative disorder in Ecuadorian children: A case series.

Indian J Dermatol Venereol Leprol 2021 Apr 12:1-5. Epub 2021 Apr 12.

Department of Dermatologic Surgery, Dermatologic Institute of Jalisco Dr. José Barba Rubio, Guadalajara, Mexico.

We report the clinical and histopathological features of hydroa vacciniforme-like lymphoproliferative disorder in five indigenous and Mestizo children. All the children resided at higher altitudes, experiencing maximal solar exposure. All cases presented with prurigo along with Epstein-Barr virus infection. Read More

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Hydroa Vacciniforme-like Lymphoproliferative disorder in an adult invades the liver and bone marrow with clear pathological evidence: a case report and literature review.

BMC Infect Dis 2021 Jan 6;21(1):17. Epub 2021 Jan 6.

Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, 8 Jingshun East Street, Chaoyang District, Beijing, 100015, China.

Background: Hydroa Vacciniforme-like Lymphoproliferative Disorder (HV-LPD) is the name given to a group of Epstein-Barr virus (EBV)-associated diseases. It resembles hydroa vacciniforme (HV), the rarest form of photosensitivity, and is a T-cell disorder associated with an Epstein-Barr virus infection. The majority of diagnosed cases occur in East Asia and South America. Read More

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January 2021

Hydroa Vacciniforme and Hydroa Vacciniforme-Like Lymphoproliferative Disorder: A Spectrum of Disease Phenotypes Associated with Ultraviolet Irradiation and Chronic Epstein-Barr Virus Infection.

Int J Mol Sci 2020 Dec 7;21(23). Epub 2020 Dec 7.

Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.

Hydroa vacciniforme (HV) is a rare form of photosensitivity disorder in children and is frequently associated with Epstein-Barr virus (EBV) infection, whereas HV-like lymphoproliferative disorders (HVLPD) describe a spectrum of EBV-associated T-cell or natural killer (NK)-cell lymphoproliferations with HV-like cutaneous manifestations, including EBV-positive HV, atypical HV, and HV-like lymphoma. Classic HV occurs in childhood with papulovesicules on sun-exposed areas, which is usually induced by sunlight and ultraviolet irradiation, and mostly resolves by early adult life. Unlike classic HV, atypical or severe HV manifests itself as recurrent papulovesicular eruptions in sun-exposed and sun-protected areas associated occasionally with facial edema, fever, lymphadenopathy, oculomucosal lesions, gastrointestinal involvement, and hepatosplenomegaly. Read More

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December 2020

A case of hydroa vacciniforme in an adult patient.

Photodermatol Photoimmunol Photomed 2021 May 8;37(3):195-197. Epub 2020 Dec 8.

Photodermatosis Service and Laser Unit, Division of Dermatology, Rabin Medical Center, Petah-Tikva, Israel.

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Hydroa vacciniforme-like lymphoproliferative disorder in Korea.

Sci Rep 2020 11 9;10(1):19294. Epub 2020 Nov 9.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) is a rare Epstein-Barr virus (EBV)-associated lymphoproliferative disease. The disease course of HVLPD varies from an indolent course to progression to aggressive lymphoma. We investigated the characteristics of HVLPD in Korean patients. Read More

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November 2020

Chronic Active Epstein-Barr Virus Infection: Is It Immunodeficiency, Malignancy, or Both?

Cancers (Basel) 2020 Oct 30;12(11). Epub 2020 Oct 30.

Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.

Chronic active Epstein-Barr virus (EBV) infection (CAEBV) is a rare syndrome characterized by prolonged infectious mononucleosis-like symptoms and elevated peripheral blood EBV DNA load in apparently immunocompetent persons. CAEBV has been primarily reported in East Asia and Latin America, suggesting a genetic predisposition in its pathogenesis. In most cases of CAEBV, EBV induces proliferation of its unusual host cells, T or natural killer (NK) cells. Read More

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October 2020

Ocular Involvement Preceded the Onset of Cutaneous Lesions in Hydroa Vacciniforme-Like Lymphoproliferative Disorder: A Case Report.

Ocul Immunol Inflamm 2020 Oct 6:1-4. Epub 2020 Oct 6.

Department of Ophthalmology, Sichuan Provincial Corps Hospital, Chinese People's Armed Police Forces, Leshan, China.

Purpose: To report a case of ocular involvement associated with hydroa vacciniforme-like lymphoproliferative disorder (HVLPD).

Case Report: A 10-year-old HVLPD boy suffered conjunctivitis, interstitial keratitis, and anterior uveitis sequentially during the whole course. Interestingly, this case manifested initially only with ocular findings, which preceded 1 year earlier than the onset of cutaneous lesions. Read More

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October 2020

Epstein-Barr virus-associated hydroa vacciniforme-like lymphoproliferative syndrome: excellent response to antiviral therapy.

Int J Dermatol 2020 Dec 17;59(12):e452-e454. Epub 2020 Aug 17.

Department of Dermatology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.

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December 2020

Hydroa vacciniforme-like lymphoproliferative disorder: A study of clinicopathology and whole-exome sequencing in Chinese patients.

J Dermatol Sci 2020 Aug 9;99(2):128-134. Epub 2020 Jul 9.

Department of Dermatovenerology, West China Hospital, Sichuan University Chengdu, China. Electronic address:

Background: Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) encompasses a rare group of Epstein-Barr virus (EBV)-associated lymphoproliferative diseases.

Objective: To define the clinical and pathologic characteristics of HVLPD and to identify mutant genes that may be related to the development of HVLPD.

Methods: Clinical data and archived formalin-fixed, paraffin-embedded tissue were obtained from 19 patients. Read More

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Hydroa vacciniforme-like lymphoproliferative disorder: a retrospective cohort study of seven pediatric cases.

Int J Dermatol 2020 Aug 13;59(8):e290-e292. Epub 2020 May 13.

Department of Dermatology & Dermatological Surgery, Medical University of South Carolina, Charleston, SC, USA.

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The aim of the measurement of Epstein-Barr virus DNA in hydroa vacciniforme and hypersensitivity to mosquito bites.

J Med Virol 2020 Apr 7. Epub 2020 Apr 7.

Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Epstein-Barr virus (EBV) DNA load in the blood increases in posttransplant lymphoproliferative disorders and chronic active EBV infection. In this report, we analyzed the EBV DNA load in the peripheral blood mononuclear cells (PBMCs) and plasma of patients with hydroa vacciniforme (HV) and/or hypersensitivity to mosquito bites (HMB) to understand the clinical significance of EBV DNA load. All 30 patients showed high DNA loads in the PBMCs over the cut-off level. Read More

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Comparison of racial distribution of photodermatoses in USA academic dermatology clinics: A multicenter retrospective analysis of 1080 patients over a 10-year period.

Photodermatol Photoimmunol Photomed 2020 May 12;36(3):233-240. Epub 2020 Mar 12.

Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.

Background: Previous studies at single academic institutions have identified variations in the prevalence of photodermatoses among racial groups. The purpose of the study was to compare the distribution of photodermatoses between Whites and Blacks at four academic medical centers in the USA.

Methods: A retrospective chart review was performed at four institutions' general dermatology clinics using diagnoses consistent with the International Classification of Disease (ICD), Ninth and Tenth Revisions, codes related to photodermatoses between August 2006 and August 2016. Read More

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Hydroa Vacciniforme-Like Lymphoma with Systemic Symptoms: Two Case Reports.

Indian J Dermatol 2019 Nov-Dec;64(6):493-496

Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China.

Two Chinese children presented with relapsing papules, vesicles, ulcers on the face and limbs with systemic symptoms being caused by mosquito bite. Lesion biopsy revealed atypical lymphocyte in the dermis and subcutis. Immunohistochemistry identified cells as positive for CD3, CD45RO, TIA-1 and EBER. Read More

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January 2020

Epstein - Barr virus positive T and NK-cell lymphoproliferations: Morphological features and differential diagnosis.

Semin Diagn Pathol 2020 Jan 17;37(1):32-46. Epub 2019 Dec 17.

Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tübingen, University Hospital Tübingen, Eberhard-Karls-University, Tübingen, Germany. Electronic address:

The spectrum of Epstein-Barr virus (EBV)-positive T and NK-cell lymphoproliferations is broad and ranges from reactive self-limited disorders to neoplastic processes with a fulminant clinical course. EBV plays an important role promoting lymphomagenesis, although the precise mechanisms remain elusive. EBV-positive lymphoproliferative disorders (LPD) are more common in East Asia (China, Japan, Korea and Taiwan), and Latin America suggesting a strong genetic predisposition. Read More

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January 2020

Epstein-Barr virus NK and T cell lymphoproliferative disease: report of a 2018 international meeting.

Leuk Lymphoma 2020 04 13;61(4):808-819. Epub 2019 Dec 13.

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Epstein-Barr virus (EBV) normally infects B cells, but in some persons the virus infects T or NK cells. Infection of B cells can result in infectious mononucleosis, and the virus is associated with several B cell malignancies including Hodgkin lymphoma, Burkitt lymphoma, and diffuse large B cell lymphoma. Infection of T or NK cells with EBV is associated with extranodal NK/T cell lymphoma, aggressive NK-cell leukemia, systemic EBV-associated T-cell lymphoma, and chronic active EBV disease, which in some cases can include hydroa vacciniforme-like lymphoproliferative disease and severe mosquito bite allergy. Read More

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Epstein-Barr virus-associated T- and NK-cell lymphoproliferative diseases: an update and diagnostic approach.

Pathology 2020 Jan 22;52(1):111-127. Epub 2019 Nov 22.

Department of Pathology, National University Hospital, National University Health System, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

Epstein-Barr virus (EBV)-positive T-cell and natural killer (NK)-cell lymphoproliferative diseases (EBV-TNKLPD) are a group of uncommon disorders characterised by EBV infection of T- and NK-cells. As a group, EBV-TNKLPD are more commonly encountered in Asians and Native Americans from Central and South America compared to Western populations. They encompass a spectrum of entities that range from non-neoplastic lesions such as EBV-associated haemophagocytic lymphohistiocytosis (EBV-HLH) to more chronic conditions with variable outcomes such as chronic active EBV infections (CAEBV) of T- and NK-cell type (cutaneous and systemic forms) and malignant diseases such as systemic EBV-positive T-cell lymphoma of childhood, aggressive NK-cell leukaemia, extranodal NK/T-cell lymphoma, nasal-type, and primary EBV-positive nodal T/NK-cell lymphoma. Read More

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January 2020

Hydroa vacciniforme-like lymphoma: clinicopathological description, treatment and outcome.

J Am Acad Dermatol 2019 Nov 20. Epub 2019 Nov 20.

Department of Dermatology & Dermatological Surgery, Medical University of South Carolina, Charleston, USA.

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November 2019

Diagnosis of T-cell lymphoid proliferations of the skin: putting all the pieces together.

Mod Pathol 2020 01 29;33(Suppl 1):83-95. Epub 2019 Oct 29.

Departments of Pathology and Dermatology, The University of Texas - MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 85, Houston, TX, 77030, USA.

The spectrum of T-cell lymphoid proliferations of the skin varies from indolent to highly aggressive diseases and therefore an accurate pathological diagnosis is paramount. Integration of clinical, histopathological, immunohistochemical, and molecular findings is of crucial importance in the evaluation of these processes. In this article, we discuss selected situations where difficulty may arise for the pathologist evaluating this type of skin biopsies, such as: the diagnosis of early (patch stage) mycosis fungoides, the distinction of mycosis fungoides with large cell transformation from primary cutaneous anaplastic large cell lymphoma, the recognition of new histopathological patterns of lymphomatoid papulosis and the entities they mimic, the evaluation of primary cutaneous anaplastic large cell lymphoma with expression of markers suggestive of systemic origin (such as ALK), the awareness of the wide range of clinical and pathological presentations of hydroa vacciniforme-like EBV-positive T-cell lymphoproliferative disorders, the evaluation of cases of primary cutaneous γδ T-cell lymphoma showing predominantly epidermotropic pattern of growth, and the correct interpretation of findings seen in indolent proliferations such as primary cutaneous acral CD8-positive T-cell lymphoma and primary cutaneous small/medium size CD4 + T-cell lymphoproliferative disorder. Read More

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January 2020

Necrotic papulovesicular lesions mainly on sun-exposed areas.

Clin Exp Dermatol 2020 Jun 22;45(4):485-489. Epub 2019 Sep 22.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

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Shift in Epstein-Barr virus (EBV)-infected cells in chronic active EBV disease.

Pediatr Int 2019 Aug 21;61(8):825-826. Epub 2019 Aug 21.

Division of Hematology, National Center for Child Health and Development, Tokyo, Japan.

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The face of CD4 Hydroa Vacciniforme-Like Lymphoproliferative Diseases: The Shadow of Systemic T-Cell Lymphoma.

Ann Dermatol 2019 Aug 1;31(Suppl):S17-S19. Epub 2019 Jul 1.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

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Editorial: Epstein-Barr Virus-Associated T/NK-Cell Lymphoproliferative Diseases.

Front Pediatr 2019 10;7:285. Epub 2019 Jul 10.

Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

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Recent Advances in Cutaneous T-cell Lymphoma: Diagnostic and Prognostic Considerations.

Surg Pathol Clin 2019 Sep;12(3):783-803

Department of Pathology, University of Virginia, PO Box 800214, 1215 Lee Street, Hospital Expansion Building Room 3018, Charlottesville, VA 22908, USA. Electronic address:

This review describes the latest advances in the diagnosis of cutaneous T-cell lymphoma focusing on the most clinically useful features introduced since the publication of the World Health Organization revision in 2017. Clinical entities described include mycosis fungoides, Sézary syndrome, lymphomatoid papulosis, primary cutaneous anaplastic large cell lymphoma, primary cutaneous gamma delta T-cell lymphoma, primary cutaneous acral CD8 T-cell lymphoma, primary cutaneous CD4 small/medium T-cell lymphoproliferative disorder, and hydroa-vacciniforme-like lymphoproliferative disorder. Distinguishing histologic clues to diagnosis are discussed, and important molecular advances are described. Read More

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September 2019

EBV-Associated Lymphoproliferative Disorders: Update in Classification.

Surg Pathol Clin 2019 Sep;12(3):745-770

Department of Pathology and Laboratory Medicine, University of California Irvine (UCI) Medical Center, 101 The City Drive, Orange, CA 92868, USA; NeoGenomics Laboratories, 31 Columbia, Aliso Viejo, CA 92656, USA. Electronic address:

Although about 90% of the world's population is infected by EBV only a small subset of the related infections result in neoplastic transformation. EBV is a versatile oncogenic agent involved in a multitude of hematopoietic, epithelial, and mesenchymal neoplasms, but the precise role of EBV in the pathogenesis of many of the associated lymphoid/histiocytic proliferations remains hypothetical or not completely understood. Additional studies and use of evolving technologies such as high-throughput next-generation sequencing may help address this knowledge gap and may lead to enhanced diagnostic assessment and the development of potential therapeutic interventions. Read More

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September 2019

Clinicopathological categorization of hydroa vacciniforme-like lymphoproliferative disorder: an analysis of prognostic implications and treatment based on 19 cases.

Diagn Pathol 2019 Jul 17;14(1):82. Epub 2019 Jul 17.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, People's Republic of China.

Background: Hydroa vacciniforme-like lymphoproliferative disorder (HV-LPD) is a cutaneous form of chronic active Epstein-Barr virus (EBV) infection, which occurs mainly in children in Latin America and Asia. It can progress to systemic lymphoma. However, prognostic factors and treatment remain unclear. Read More

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