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Placenta 2019 Feb 5;77:58-64. Epub 2019 Feb 5.

Placental Related Disease Research Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Thailand. Electronic address:

Introduction: Protein expression in cells are associated with oncogenesis. This study aims to explore proteomic profiles and discover potential biomarkers that can predict malignant transformation of hydatidiform mole.

Methods: Retrospective analysis was done in 14 cases of remission hydatidiform mole and 14 cases of hydatidiform mole who later developed malignancy (GTN group). Read More

World J Clin Oncol 2019 Feb;10(2):28-37

Department of Medical Oncology, Charing Cross Gestational Trophoblastic Disease Centre, Charing Cross Hospital, Imperial College London, London W6 8RF, United Kingdom.

Gestational trophoblastic neoplasia (GTN) is a rare tumor that originates from pregnancy that includes invasive mole, choriocarcinoma (CCA), placental site trophoblastic tumor and epithelioid trophoblastic tumor (PSTT/ETT). GTN presents different degrees of proliferation, invasion and dissemination, but, if treated in reference centers, has high cure rates, even in multi-metastatic cases. The diagnosis of GTN following a hydatidiform molar pregnancy is made according to the International Federation of Gynecology and Obstetrics (FIGO) 2000 criteria: four or more plateaued human chorionic gonadotropin (hCG) concentrations over three weeks; rise in hCG for three consecutive weekly measurements over at least a period of 2 weeks or more; and an elevated but falling hCG concentrations six or more months after molar evacuation. Read More

PeerJ 2019 20;7:e6490. Epub 2019 Feb 20.

Department of Obstetrics and Gynecology, College of Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea.

Introduction: We investigated the rate and longitudinal trends of gestational trophoblastic disease (GTD) incidence in the Republic of Korea between 2009 and 2015 using population-based data.

Materials And Methods: Data of patients diagnosed with GTD from 2009 to 2015 were obtained from the Health Insurance Review and Assessment Service/National Inpatient Sample (HIRA-NIS) in the Republic of Korea. The HIRA annually provides the HIRA-NIS, a collection of clinical data from over one million people. Read More

J Gynecol Oncol 2019 Mar 23;30(2):e16. Epub 2018 Nov 23.

Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Objective: To investigate the significance of lung nodule in hydatidiform mole, we retrospectively compared the clinical outcomes of those patients treated with different strategies.

Methods: The patients were divided into three groups: chemotherapy immediately once lung nodule was detected (group 1, n=17), delayed chemotherapy until human chorionic gonadotrophin (hCG) level met the diagnostic criteria for gestational trophoblastic neoplasia (GTN) (group 2, n=18), and hCG surveillance alone until hCG level was normalized spontaneously (group 3, n=18). The clinical parameters of these patients were collected and analyzed. Read More

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):54-60

Department of Pathology, S.C.B. Medical Colllege, Cuttack, Odisha, India.

Background: Gestational trophoblastic disease (GTD) constitutes a spectrum of tumors and tumor-like conditions, characterized by proliferation of pregnancy-associated trophoblastic tissue of progressive malignant potential. It is very difficult to differentiate these complex groups of lesions basing on histomorphology alone. Immunohistochemistry (IHC) with cyclin E, P63, and Ki-67 has a definite role in the identification of different trophoblasts and entities of GTD and also in the determination of biological behavior. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Mar 6;234:117-119. Epub 2019 Jan 6.

Trophoblastic Disease Centre, Charing Cross Hospital, London, UK.

Objective: To determine whether post-pregnancy human chorionic gonadotrophin screening after previous hydatidiform mole identifies patients with recurrent gestational trophoblastic disease.

Study Design: A retrospective evaluation of 9315 patients who underwent post-pregnancy screening from 2000 to 2009, as part of the National Gestational Trophoblastic Disease Service in the UK.

Results: Patients with previous hydatidiform mole, who had human chorionic gonadotrophin screening after one or more subsequent pregnancies, were identified (n = 9315). Read More

JSLS 2019 Jan-Mar;23(1)

Department of Anesthesiology and Pain Medicine, Uijeongbu St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea.

Introduction: Uterine-conservative surgery via laparoscopy is a challengeable and high risk because of heavy intra-operative bleeding events in reproductive women with highly vascular uterine benign disease. There are three reported cases of women with highly vascular uterine benign diseases and high risk of intra-operative heavy bleeding, but were treated successfully to control intra-operative heavy bleeding risk by transient occlusion of the uterine artery (TOUA) through laparoscopy and resulted in safe conservation of the uterus.

Case Presentation: The cases of women with high risk of heavy bleeding during therapeutic procedure included cesarean scar pregnancy, hydatid form mole on cesarean scar, and cervical pregnancy. Read More

Int J Gynecol Cancer 2019 Jan;29(1):108-112

Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, The Netherlands.

Objectives: Because gestational trophoblastic disease is rare, little evidence is available from randomized controlled trials on optimal treatment and follow-up. Treatment protocols vary within Europe, and even between different centers within countries. One of the goals of the European Organization for Treatment of Trophoblastic Diseases (EOTTD) is to harmonize treatment in Europe. Read More

BMC Cancer 2019 Jan 7;19(1):13. Epub 2019 Jan 7.

Department of Obstetrics and Gynecology, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, 310006, Zhejiang Province, China.

Background: The clinical value of total hysterectomy for patients with hydatidiform mole (HM) being at least 40 years old remains highly controversial. Since the practice of hysterectomy has been applied globally for decades, there is an urgent need to perform a systematic review to assess its risks and benefits.

Methods: Six electronic databases, including four English databases and one Chinese database, were searched from the inception of each database till October 6th 2017. Read More

Nuklearmedizin 2018 Dec 18;57(6):N57. Epub 2018 Dec 18.

Pathol Res Pract 2019 Mar 12;215(3):446-452. Epub 2018 Dec 12.

Pathology Department, Farhet Hached Hospital, 4000 Sousse, Tunisia; Medicine Faculty of Sousse, University of Sousse, 4000 Sousse, Tunisia.

Hydatidiform moles (HM) are characterized by an abnormal proliferating trophoblast with a potential for a malignant transformation. Similar to other human tumors, trophoblastic pathogenesis is likely a multistep process involving several molecular and genetic alterations. The study was performed to investigate the expression patterns of c-erbB-2 and Bcl-2 oncoproteins, p53, p21 and p63 tumor suppressor proteins and Ki-67 cell proliferation marker in HM. Read More

Twin Res Hum Genet 2018 12 7;21(6):563-569. Epub 2018 Dec 7.

Department of Psychology,California State University,Fullerton,California,USA.

Twin research has found genetic influence underlying vocational interests, work values, and job satisfaction. In addition, numerous studies have shown that monozygotic (MZ) twins generally display greater within-pair cooperation and social closeness than dizygotic (DZ) twins. These findings are illuminated by exploring the occupational histories of two female twin pairs, one set MZ and the other set DZ. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13439

Interdisciplinary Department of Medicine, Gynecology and Obstetrics Clinic, University of Bari.

Rationale: Placental site trophoblastic tumor (PSTT) is a very rare malignant tumor, belonging to a family of pregnancy-related illnesses, called gestational trophoblastic diseases (GTD). Less than 300 cases of PSTT have been reported in literature, with an incidence of ≈ 1/50,000-100,000 pregnancies representing only 0.23% to 3. Read More

Arch Pathol Lab Med 2018 Dec;142(12):1485-1502

From the Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.

Context.—: Distinction of hydatidiform moles from nonmolar specimens and subclassification of hydatidiform moles as complete hydatidiform mole versus partial hydatidiform mole are important for clinical practice and investigational studies. Risk of persistent gestational trophoblastic disease and clinical management differ for these entities. Read More

Oncol Lett 2018 Nov 20;16(5):6458-6464. Epub 2018 Sep 20.

Jiangxi Provincial Key Laboratory of Reproductive Physiology and Pathology, Department of Physiology, School of Medicine, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Uterine natural killer (uNK) cells have been hypothesized to serve a role in controlling trophoblast invasion and proliferation. The aim of the present study was to identify the distribution and number of uNK cells in normal pregnancy (NP), partial mole (PM), complete mole (CM) and invasive mole (IM). uNK cells were detected using dolichos biflorus agglutinin lectin immunohistochemistry in decidual and villous tissues from early NP (n=15), late NP (n=15), PM (n=22), CM (n=20) and IM (n=10). Read More

Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Radboud University Medical Centre Nijmegen, Nijmegen, Netherlands.

Gestational trophoblastic disease (GTD) arises from abnormal placenta and is composed of a spectrum of premalignant to malignant disorders. Changes in epidemiology of GTD have been noted in various countries. In addition to histology, molecular genetic studies can help in the diagnostic pathway. Read More

Abdom Radiol (NY) 2018 Oct 4. Epub 2018 Oct 4.

Imaging Department, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627, São Paulo, 05652-901, Brazil.

The original version of this article contained a mistake in the co-author's first name. The co-author name should read as "Mariana Athaniel Silva Rodrigues" instead of "Marina Athaniel Silva Rodrigues". It is now corrected with this erratum. Read More

Kobe J Med Sci 2018 May 28;64(1):E1-E5. Epub 2018 May 28.

Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Both twin pregnancies with complete hydatidiform mole and coexisting normal fetus (CHMCF) and partial hydatidiform mole can be found in association with a live fetus and a placenta displaying a molar degeneration. Two cases of CHMCF using magnetic resonance imaging (MRI) for a diagnosis are reported.

Case: In the first, CHMCF was suspected at 12 weeks of gestation. Read More

Clin Epidemiol 2018 18;10:1223-1231. Epub 2018 Sep 18.

Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.

Purpose: To examine the validity of registration of hydatidiform mole (HM) in the Danish National Patient Registry (NPR), the Danish Cancer Registry (DCR), and the Danish Pathology Registry (DPR).

Patients And Methods: We selected women registered with a first-time HM code in NPR, DCR, and DPR from 1999 to 2009. We found most women registered in DPR. Read More

BMJ Case Rep 2018 Sep 27;2018. Epub 2018 Sep 27.

Department of Obstetrics and Gynaecology, Our Lady of Lourdes Hospital, Drogheda, Ireland.

The classic features of molar pregnancy are irregular vaginal bleeding, hyperemesis, enlarged uterus for gestational age and early failed pregnancy. Less common presentations include hyperthyroidism, early onset pre-eclampsia or abdominal distension due to theca lutein cysts. Here, we present a case of molar pregnancy where a woman presented to the emergency department with symptoms of acute abdomen and was treated as ruptured ectopic pregnancy. Read More

Medicine (Baltimore) 2018 Sep;97(38):e12424

Department of Obstetrics and Gynecology, West China Second Hospital of Sichuan University.

Rationale: Familial hydatidiform mole is extremely rare while familial gestational trophoblastic neoplasia (GTN) has never been reported. Inspired by 2 biological sisters with postmolar GTN and liver toxicity, we reviewed susceptible maternal-effect genes and explored the role of possible drug transporter genes in the development of GTN.

Patient Concerns: We reported one Chinese family where the two sisters developed postmolar GTN while experiencing fast remission and significant hepatic toxicity from actinomycin D chemotherapy. Read More

Placenta 2018 Sep 6;69:64-70. Epub 2018 Jul 6.

Hacettepe University, Faculty of Medicine Department of Obstetrics and Gynecology, 06100, Sihhiye, Ankara, Turkey.

Introduction: Leukemia inhibitory factor (LIF) and insulin like growth factor-1 (IGF-1) are two of the most important growth factors mediating trophoblast actions. We hypothesized that the localization and expression patterns of LIF and IGF-1 in partial and complete hydatidiform moles (HM) compared with normal first trimester placentas may provide an understanding of the proliferative processes in HMs.

Methods: The study population included curettage material of women diagnosed as complete or partial HM as a result of histopathological and immunohistochemical examination (complete HM group, n = 8; partial HM group, n = 8) and women undergoing dilatation&curettage for unwanted pregnancies (control group, n = 8). Read More

J Zoo Wildl Med 2018 Sep;49(3):828-832

A 47-yr-old multiparous female bonobo ( Pan paniscus) tested positive for pregnancy on a routine urine test. Because this geriatric animal was considered postreproductive, oral contraception had been discontinued. Sequential transabdominal ultrasound evaluations were performed under voluntary behavior and revealed that the uterus contained a mass of heterogenous tissue which was rapidly increasing in size. Read More

Case Rep Womens Health 2018 Jul 31;19:e00072. Epub 2018 Jul 31.

Department of Obstetrics and Gynecology, SBH Health System, 4422 Third Ave, Bronx, NY 10457, USA.

Background: Gestational trophoblastic disease (GTD) is a rare developmental form of proliferative trophoblastic tissue. Sparse literature exists regarding the optimal management of patients with advanced GTD, but the definitive treatment is urgent surgical intervention.

Case: A 48-year-old woman presented advanced GTD. Read More

Ultrasound 2018 Aug 2;26(3):153-159. Epub 2018 Mar 2.

Kings College Hospital, London, UK.

Introduction: The primary aims of this study were to establish what proportion of ultrasonically suspected molar pregnancies were proven on histological examination and what proportion of histologically diagnosed molar pregnancies were identified by ultrasound pre-operatively. The secondary aim was to review the features of these scans to help identify criteria that may improve ultrasound diagnosis.

Methods: This was a retrospective observational study conducted in the Early Pregnancy Unit at King's College Hospital London over an 11-year period. Read More

Biochem Biophys Res Commun 2018 09 21;503(4):3155-3161. Epub 2018 Aug 21.

Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea. Electronic address:

The trophoblast cells which form the placenta, have a high potential for invading other tissues. Owing to certain mechanisms, trophoblast cells may lose their ability to control cell proliferation, and develop into pregnancy-related tumors, known as choriocarcinomas. Choriocarcinomas mostly develop from the hydatidiform mole, which is frequently found in pregnant women. Read More

Pathologe 2018 Sep;39(5):431-444

Klinik und Poliklinik für Frauenheilkunde, Klinikums rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, München, Deutschland.

Ectopic pregnancies are the main sources of pregnancy-related morbidity and mortality in the first trimester. They are usually located in the ampullary part of the fallopian tube and the incidence increases in the setting of assisted reproductive techniques, older age at the time of the first pregnancy, and prior adnexal procedures. The clinical aspects and diagnostic challenges of an ectopic pregnancy for the pathologist are to be outlined. Read More

APMIS 2018 Jul;126(7):647-654

Department of Pathology & Laboratory Medicine, Rutgers-New Jersey Medical School, Newark, NJ, USA.

Gestational trophoblastic disease can be a challenging area for pathologic evaluation. An update with a focus on pathologic challenges is presented. Read More

Taiwan J Obstet Gynecol 2018 Aug;57(4):588-593

Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, Kashihara-City, Nara-Prefecture, 634-8522, Japan.

Objective: Twin pregnancy with complete hydatidiform mole and coexisting fetus (CHMCF) is rare and associated with severe complications during pregnancy and subsequent gestational trophoblastic disease (GTD). We encountered a case of multiple metastatic GTD after a twin pregnancy with CHMCF, following conventional in vitro fertilization (IVF). Only one case of metastatic GTD after CHMCF due to assisted reproductive technology (ART) has been reported. Read More

Thyroid Res 2018 10;11:12. Epub 2018 Aug 10.

Nature Coast Healthcare Center, Tallahassee, FL USA.

Background: The hallmark of gestational trophoblastic disease is the production of human chorionic gonadotropin (hCG) due to the hyperproliferation of extraembryonic trophoblast cells. Previous studies show hCG has thyrotropic action due to its structural similarity with thyroid stimulating hormone (TSH) molecules. Germ cell tumors represent 15-20% of all ovarian tumors and can be malignant or benign. Read More

Zhonghua Bing Li Xue Za Zhi 2018 Aug;47(8):609-615

Department of Pathology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100006, China.

To investigate the value of short tandem repeat (STR) genotyping in the diagnostic workup of molar and non-molar gestations with correlation of histological characteristics. Six hundred and fifty-six cases were selected based on clinically suspected hydropic abortion and/or molar pregnancy from July 2015 to September 2017 at Beijing Obstetrics and Gynecology Hospital. DNA was extracted from dissected chorionic villi and paired maternal endometrial FFPE tissue samples by Simplex OUP™ FFPE DNA Tissue Kit. Read More

Med Humanit 2019 Mar 7;45(1):2-9. Epub 2018 Aug 7.

Department of Human Genetics and Genomics Medicine, Faculty of Medicine, University of Southampton, Southampton, UK.

The medieval English romance gives an account of a birth of a lump of flesh. This has been considered as fantastic and monstrous in past literature, the horrific union of a Christian and Saracen. However, while the text certainly speaks to miscegenation, we propose that this lump of flesh is actually a hydatidiform mole. Read More

Med Sci Law 2018 Jul 3;58(3):189-193. Epub 2018 Jul 3.

3 Department of Forensic Medicine, Maulana Azad Medical College, New Delhi, India.

Pulmonary metastasis is a well-known complication of an invasive mole. However, sudden death due to haemoptysis resulting from a metastatic invasive mole is extremely rare. We report the sudden unexpected death of an 18-year-old primigravida following a molar pregnancy. Read More

Zhonghua Fu Chan Ke Za Zhi 2018 Jun;53(6):390-395

Department of Gynecology Oncology, Dalian Maternal and Child Health Care Hospital, Dalian Obstetrics and Gynecology Hospital Affiliated to Dalian Medical University, Dalian 116033, China.

To explore the clinical significance of centralized surveillance of hydatidiform mole. From Feb. 2013 to Feb. Read More

J Obstet Gynaecol Res 2018 Aug 28;44(8):1482-1486. Epub 2018 Jun 28.

Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.

Retained products of conception with marked vascularity can cause massive postabortal or post-partum bleeding. Uterine artery embolization is effective for uterus preservation but does not assure fertility preservation. Thus, the optimal treatment for retained products of conception with marked vascularity is uncertain. Read More

Medicine (Baltimore) 2018 06;97(26):e11312

Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China.

Rationale: The incidence of molar pregnancy in the cesarean scar is exceedingly low, however, the disease may carry a high risk of uncontrolled hemorrhage or uterine rupture. So far managements of this disease were rarely reported in literature.

Patient Concerns: We reported a 28-year-old woman presented to our hospital with a complaint of amenorrhea for 48 days and vaginal bleeding for 3 days. Read More

Placenta 2018 05 7;65:29-36. Epub 2018 Apr 7.

University Paris Saclay Saint-Aubin, France; INSERM U1197 Stem Cell-Niches Interactions: Physiology, Tumors and Tissular Repair, Hospital Paul Brousse, Bâtiment Lavoisier, Villejuif, France. Electronic address:

Introduction: Hydatidiform mole (HM) is an aberrant human pregnancy with abnormal trophoblastic development, migration/invasion of the extravillous trophoblast in the decidua. These abnormalities are established in a hypoxic environment during the first trimester of gestation.

Methods: Using text mining, we identified 72 unique genes that are linked to HM (HM-linked genes) that we studied by bioinformatic analysis in publicly available transcriptomes of primary chorionic villous cells (cytotrophoblast, syncytiotrophoblast, extravillous trophoblast, and arterial and venous endothelial) isolated from normal placentas or established trophoblastic cell lines cultured under different oxygen concentrations. Read More

BJOG 2018 09 18;125(10):1234. Epub 2018 Jul 18.

Great Ormond Street Hospital, London, WC1N 3JH, UK.

Gynecol Oncol 2018 08 8;150(2):282-287. Epub 2018 Jun 8.

University of Lyon 1, University Hospital Lyon Sud, Department of Gynecological Surgery and Oncology, Obstetrics, Pierre Bénite, France; French Center for Trophoblastic Diseases, University Hospital Lyon Sud, Pierre Bénite, France. Electronic address:

Background: Low-risk gestational trophoblastic neoplasia (GTN) patients (FIGO score ≤6) are generally treated with single agent chemotherapy (methotrexate or dactinomycin) resulting in a 5-year mortality rate of 0.3%. However, despite these encouraging survival rates, chemotherapy is associated with significant adverse events in most patients. Read More

Ultrasound Obstet Gynecol 2018 10;52(4):552-554

Department of Perinatology and Gynecology, Kagawa University Graduate School of Medicine, Miki, Kagawa, Japan.

Pan Afr Med J 2018;29:27. Epub 2018 Jan 12.

Centre Hospitalier Universitaire Ibn Rochd, Faculté de Médecine et Pharmacie, Hassan II University of Casablanca, Casablanca, Maroc.

J Assist Reprod Genet 2018 Aug 2;35(8):1533-1536. Epub 2018 Jun 2.

Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

J Obstet Gynaecol Res 2018 Aug 29;44(8):1476-1481. Epub 2018 May 29.

Department of Obstetrics and Gynecology, Kobe City Medical Center General Hospital, Kobe, Japan.

Gestational trophoblastic neoplasm (GTN) is a serious morbidity of complete hydatidiform mole with coexistent fetus (CHMCF) and usually develops after termination of pregnancy. Here we report a case of choriocarcinoma derived from CHMCF during pregnancy. A 33-year-old multiparous woman with suspected CHMCF was admitted with a severe cough. Read More

Obstet Gynecol Int 2018 1;2018:9561413. Epub 2018 Apr 1.

Makerere University, Kampala, Uganda.

Objective: We sought to determine the prevalence of and factors associated with hydatidiform molar gestations amongst patients undergoing uterine evacuation at Mbarara Regional Referral Hospital (MRRH), Mbarara, Uganda.

Methods: This was a cross-sectional study carried out from November 2016 to February 2017. All patients admitted for uterine evacuation for nonviable pregnancy were included. Read More

BMC Cancer 2018 May 23;18(1):585. Epub 2018 May 23.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Shuaifuyuan No.1, Dongcheng District, Beijing, 100730, China.

Background: Little data exists predicting the resistance to actinomycin D (Act-D) single-agent for gestational trophoblastic neoplasia (GTN). The objective was to determine the overall success of pulse Act-D and the factors predictive of resistance to pulse Act-D in the treatment of low-risk, non-choriocarcinoma post-molar GTN.

Methods: From January 2013 to October 2016, according to the FIGO criteria for the diagnosis of post-molar disease and the FIGO risk-factor scoring system for GTN, a total of 135 patients with post-molar non-choriocarcinoma GTN who were chemotherapy-naive with a FIGO score < 7 were treated with single-agent pulse Act-D as a first-line regimen, in Peking Union Medical College Hospital. Read More

J Exp Ther Oncol 2018 May;12(3):207-210

Department of Obstetrics and Gynecology, Dr. Zekai Tahir Burak Women's Health Research and Practice Center, University of Health Sciences, Ankara, Turkey.

Objective: Incidence of molar pregnancy is 1-3/1000 pregnancies. Invasive mole is a local invasive form of gestational trophoblastic neoplasias which is mostly seen in reproductive age and usually follows a molar pregnancy and rarely has an initial presentation. Ectopic pregnancy in rudimentary uterine horn is extremely rare and is seen in 1/100,000 - 140,000 pregnancies. Read More

BJOG 2018 Sep 15;125(10):1226-1233. Epub 2018 Jun 15.

Department of Public Health, Federal University of Health Science - UFCSPA, Porto Alegre, Brazil.

Background: Distinguishing hydatidiform moles (HMs) from nonmolar specimens and the subclassification of HM are important because complete hydatidiform mole (CHM) is associated with an increased risk of development of gestational trophoblastic neoplasia. However, diagnosis based solely on morphology has poor inter-observer reproducibility. Recent studies have demonstrated that the use of p57 immunostaining improves diagnostic accuracy for CHM. Read More

J Med Case Rep 2018 May 21;12(1):140. Epub 2018 May 21.

Department of Obstetrics & Gynecology Miri General Hospital, Sarawak, Malaysia.

Background: While gestational trophoblastic disease is not rare, hydatidiform mole with a coexistent live fetus is a very rare condition occurring in 0.005 to 0.01% of all pregnancies. Read More

Rev Bras Ginecol Obstet 2018 May 16;40(5):294-299. Epub 2018 May 16.

Department of Pathology, Universidade Federal Fluminense, Niterói, RJ, Brazil.

This report presents the case of a patient with gestational trophoblastic neoplasia after a partial hydatidiform mole formed in the Fallopian tube. Ectopic molar pregnancy is a rare condition, with an estimated incidence of 1 in every 20,000 to 100,000 pregnancies; less than 300 cases of it have been reported in the Western literature. The present report is important because it presents current diagnostic criteria for this rare condition, which has been incorrectly diagnosed in the past, not only morphologically but also immunohistochemically. Read More

J Assist Reprod Genet 2018 Jun 8;35(6):967-973. Epub 2018 May 8.

3rd Department of Obstetrics and Gynaecology, Hippokration General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Benign hydatidiform mole, complete or partial, is the most common type of gestational trophoblastic disease (GTD) characterised by excessive trophoblastic proliferation and abnormal embryonic development. Although most complete hydatidiform moles (CHMs) are diploid androgenetic, a few cases of CHMs are biparental, characterised by recurrence and familial clustering. In these rare cases, mutations in NLRP7 or KHDC3L genes, associated with maternal imprinting defects, have been implicated. Read More