5,687 results match your criteria Hydatidiform Mole


Management of placental site trophoblastic tumor: Two case reports.

Medicine (Baltimore) 2018 Nov;97(48):e13439

Interdisciplinary Department of Medicine, Gynecology and Obstetrics Clinic, University of Bari.

Rationale: Placental site trophoblastic tumor (PSTT) is a very rare malignant tumor, belonging to a family of pregnancy-related illnesses, called gestational trophoblastic diseases (GTD). Less than 300 cases of PSTT have been reported in literature, with an incidence of ≈ 1/50,000-100,000 pregnancies representing only 0.23% to 3. Read More

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November 2018
2 Reads

Hydatidiform Moles: Ancillary Techniques to Refine Diagnosis.

Arch Pathol Lab Med 2018 Dec;142(12):1485-1502

From the Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.

Context.—: Distinction of hydatidiform moles from nonmolar specimens and subclassification of hydatidiform moles as complete hydatidiform mole versus partial hydatidiform mole are important for clinical practice and investigational studies. Risk of persistent gestational trophoblastic disease and clinical management differ for these entities. Read More

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December 2018
2 Reads

Lectin histochemical analysis of uterine natural killer cells in normal, hydatidiform molar and invasive molar pregnancy.

Oncol Lett 2018 Nov 20;16(5):6458-6464. Epub 2018 Sep 20.

Jiangxi Provincial Key Laboratory of Reproductive Physiology and Pathology, Department of Physiology, School of Medicine, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Uterine natural killer (uNK) cells have been hypothesized to serve a role in controlling trophoblast invasion and proliferation. The aim of the present study was to identify the distribution and number of uNK cells in normal pregnancy (NP), partial mole (PM), complete mole (CM) and invasive mole (IM). uNK cells were detected using dolichos biflorus agglutinin lectin immunohistochemistry in decidual and villous tissues from early NP (n=15), late NP (n=15), PM (n=22), CM (n=20) and IM (n=10). Read More

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November 2018
3 Reads

Causative Mutations and Mechanism of Androgenetic Hydatidiform Moles.

Am J Hum Genet 2018 Nov;103(5):740-751

Department of Human Genetics, McGill University Health Centre, Montréal, QC H4A 3J1, Canada; Department of Obstetrics and Gynecology, McGill University Health Centre, Montréal, QC H4A 3J1, Canada. Electronic address:

Androgenetic complete hydatidiform moles are human pregnancies with no embryos and affect 1 in every 1,400 pregnancies. They have mostly androgenetic monospermic genomes with all the chromosomes originating from a haploid sperm and no maternal chromosomes. Androgenetic complete hydatidiform moles were described in 1977, but how they occur has remained an open question. Read More

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November 2018

Gestational Trophoblastic Neoplasia From Genetically Confirmed Hydatidiform Moles: Prospective Observational Cohort Study.

Int J Gynecol Cancer 2018 Nov;28(9):1772-1780

Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.

Objective: The aim of this study was to evaluate the incidence and risk factors of gestational trophoblastic neoplasia (GTN) from hydatidiform moles (HMs) cytogenetically diagnosed in a prospective cohort setting.

Methods: The prospective observational cohort study included cases of cytogenetically defined molar pregnancies, which were diagnosed by a multiplex short tandem repeat polymorphism analysis. Cases were classified as androgenetic complete HMs (CHMs), diandric monogynic triploid partial HMs (PHMs), or biparental abortion. Read More

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November 2018
1 Read

Analysis of PD-L1 expression in trophoblastic tissues and tumors.

Hum Pathol 2018 Oct 16. Epub 2018 Oct 16.

Center for Uterine Cancer Diagnosis & Therapy of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang Province 310006, China; The Institute of Translational Medicine, School of Medicine, Zhejiang University, Zhejiang Province 310006, China. Electronic address:

The immune checkpoint proteins, Programmed Death Receptor 1 (PD-1) and Programmed Death Ligand -1 (PD-L1), are crucial for maintaining fetomaternal immune tolerance and immune escape in cancers. In this study, we performed a comprehensive immunohistochemical study of PD-L1 expression in a large cohort of trophoblastic tissues and tumors. We found that normal villi and hydatidiform moles showed a heterogeneous PD-L1 staining among trophoblast (strong in syncytiotrophoblast, moderate in intermediate trophoblast, and weak/negative in cytotrophoblast). Read More

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October 2018
4 Reads

Genome amplification and cellular senescence are hallmarks of human placenta development.

PLoS Genet 2018 Oct 12;14(10):e1007698. Epub 2018 Oct 12.

Department of Obstetrics and Gynaecology, Reproductive Biology Unit, Medical University of Vienna, Vienna, Austria.

Genome amplification and cellular senescence are commonly associated with pathological processes. While physiological roles for polyploidization and senescence have been described in mouse development, controversy exists over their significance in humans. Here, we describe tetraploidization and senescence as phenomena of normal human placenta development. Read More

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October 2018
9 Reads

Versican silencing in BeWo cells and its implication in gestational trophoblastic diseases.

Histochem Cell Biol 2018 Oct 8. Epub 2018 Oct 8.

Cell Biology Laboratory, Institute of Health and Biological Sciences, Federal University of Alagoas, Campus A.C. Simões. Av. Lourival Melo Mota, s/n, 57072-970, Maceio, Alagoas, Brazil.

Versican is a proteoglycan known to interact with cells to influence their ability to proliferate, differentiate, migrate, invade and assemble extracellular matrix, with all of these cell functions present during placentation. In the placenta, cytotrophoblast cells have the ability to differentiate into the syncytiotrophoblast, a mechanism that is greatly increased in gestational trophoblastic diseases (GTD). Nevertheless, the molecular signaling underlying the increased syncytiotrophoblast differentiation are still being unveiled and may result in novel therapeutic targets for GTD. Read More

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October 2018
7 Reads

Correction to: ''Bunch of grapes'' in complete hydatidiform mole.

Abdom Radiol (NY) 2018 Oct 4. Epub 2018 Oct 4.

Imaging Department, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627, São Paulo, 05652-901, Brazil.

The original version of this article contained a mistake in the co-author's first name. The co-author name should read as "Mariana Athaniel Silva Rodrigues" instead of "Marina Athaniel Silva Rodrigues". It is now corrected with this erratum. Read More

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October 2018
2 Reads

Ultrasound and MRI Findings of Twin Pregnancies with Complete Hydatidiform Mole and Coexisting Normal Fetus: Two Case Reports.

Kobe J Med Sci 2018 May 28;64(1):E1-E5. Epub 2018 May 28.

Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Both twin pregnancies with complete hydatidiform mole and coexisting normal fetus (CHMCF) and partial hydatidiform mole can be found in association with a live fetus and a placenta displaying a molar degeneration. Two cases of CHMCF using magnetic resonance imaging (MRI) for a diagnosis are reported.

Case: In the first, CHMCF was suspected at 12 weeks of gestation. Read More

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May 2018
4 Reads

Hydatidiform mole: validity of the registration in the Danish National Patient Registry, the Danish Cancer Registry, and the Danish Pathology Registry 1999-2009.

Clin Epidemiol 2018 18;10:1223-1231. Epub 2018 Sep 18.

Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.

Purpose: To examine the validity of registration of hydatidiform mole (HM) in the Danish National Patient Registry (NPR), the Danish Cancer Registry (DCR), and the Danish Pathology Registry (DPR).

Patients And Methods: We selected women registered with a first-time HM code in NPR, DCR, and DPR from 1999 to 2009. We found most women registered in DPR. Read More

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September 2018
2 Reads

Atypical presentation of molar pregnancy.

BMJ Case Rep 2018 Sep 27;2018. Epub 2018 Sep 27.

Department of Obstetrics and Gynaecology, Our Lady of Lourdes Hospital, Drogheda, Ireland.

The classic features of molar pregnancy are irregular vaginal bleeding, hyperemesis, enlarged uterus for gestational age and early failed pregnancy. Less common presentations include hyperthyroidism, early onset pre-eclampsia or abdominal distension due to theca lutein cysts. Here, we present a case of molar pregnancy where a woman presented to the emergency department with symptoms of acute abdomen and was treated as ruptured ectopic pregnancy. Read More

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September 2018
2 Reads

Hepatic toxicity following actinomycin D chemotherapy in treatment of familial gestational trophoblastic neoplasia: A case report.

Medicine (Baltimore) 2018 Sep;97(38):e12424

Department of Obstetrics and Gynecology, West China Second Hospital of Sichuan University.

Rationale: Familial hydatidiform mole is extremely rare while familial gestational trophoblastic neoplasia (GTN) has never been reported. Inspired by 2 biological sisters with postmolar GTN and liver toxicity, we reviewed susceptible maternal-effect genes and explored the role of possible drug transporter genes in the development of GTN.

Patient Concerns: We reported one Chinese family where the two sisters developed postmolar GTN while experiencing fast remission and significant hepatic toxicity from actinomycin D chemotherapy. Read More

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September 2018
6 Reads

Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles.

Placenta 2018 Sep 6;69:64-70. Epub 2018 Jul 6.

Hacettepe University, Faculty of Medicine Department of Obstetrics and Gynecology, 06100, Sihhiye, Ankara, Turkey.

Introduction: Leukemia inhibitory factor (LIF) and insulin like growth factor-1 (IGF-1) are two of the most important growth factors mediating trophoblast actions. We hypothesized that the localization and expression patterns of LIF and IGF-1 in partial and complete hydatidiform moles (HM) compared with normal first trimester placentas may provide an understanding of the proliferative processes in HMs.

Methods: The study population included curettage material of women diagnosed as complete or partial HM as a result of histopathological and immunohistochemical examination (complete HM group, n = 8; partial HM group, n = 8) and women undergoing dilatation&curettage for unwanted pregnancies (control group, n = 8). Read More

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September 2018
5 Reads

ANTEMORTEM DIAGNOSIS AND SUCCESSFUL TREATMENT OF A COMPLETE MOLAR PREGNANCY IN A GERIATRIC BONOBO ( PAN PANISCUS).

J Zoo Wildl Med 2018 Sep;49(3):828-832

A 47-yr-old multiparous female bonobo ( Pan paniscus) tested positive for pregnancy on a routine urine test. Because this geriatric animal was considered postreproductive, oral contraception had been discontinued. Sequential transabdominal ultrasound evaluations were performed under voluntary behavior and revealed that the uterus contained a mass of heterogenous tissue which was rapidly increasing in size. Read More

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September 2018
9 Reads

Advanced gestational trophoblastic disease: A case report of medical management prior to surgical intervention.

Case Rep Womens Health 2018 Jul 31;19:e00072. Epub 2018 Jul 31.

Department of Obstetrics and Gynecology, SBH Health System, 4422 Third Ave, Bronx, NY 10457, USA.

Background: Gestational trophoblastic disease (GTD) is a rare developmental form of proliferative trophoblastic tissue. Sparse literature exists regarding the optimal management of patients with advanced GTD, but the definitive treatment is urgent surgical intervention.

Case: A 48-year-old woman presented advanced GTD. Read More

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July 2018
3 Reads

Ultrasound diagnosis of molar pregnancy.

Ultrasound 2018 Aug 2;26(3):153-159. Epub 2018 Mar 2.

Kings College Hospital, London, UK.

Introduction: The primary aims of this study were to establish what proportion of ultrasonically suspected molar pregnancies were proven on histological examination and what proportion of histologically diagnosed molar pregnancies were identified by ultrasound pre-operatively. The secondary aim was to review the features of these scans to help identify criteria that may improve ultrasound diagnosis.

Methods: This was a retrospective observational study conducted in the Early Pregnancy Unit at King's College Hospital London over an 11-year period. Read More

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August 2018
3 Reads

Chrysin disrupts intracellular homeostasis through mitochondria-mediated cell death in human choriocarcinoma cells.

Biochem Biophys Res Commun 2018 Sep 21;503(4):3155-3161. Epub 2018 Aug 21.

Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea. Electronic address:

The trophoblast cells which form the placenta, have a high potential for invading other tissues. Owing to certain mechanisms, trophoblast cells may lose their ability to control cell proliferation, and develop into pregnancy-related tumors, known as choriocarcinomas. Choriocarcinomas mostly develop from the hydatidiform mole, which is frequently found in pregnant women. Read More

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September 2018
2 Reads

[Histopathology and clinical aspects of extrauterine pregnancy].

Pathologe 2018 Sep;39(5):431-444

Klinik und Poliklinik für Frauenheilkunde, Klinikums rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, München, Deutschland.

Ectopic pregnancies are the main sources of pregnancy-related morbidity and mortality in the first trimester. They are usually located in the ampullary part of the fallopian tube and the incidence increases in the setting of assisted reproductive techniques, older age at the time of the first pregnancy, and prior adnexal procedures. The clinical aspects and diagnostic challenges of an ectopic pregnancy for the pathologist are to be outlined. Read More

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September 2018
8 Reads

Update on the pathology of gestational trophoblastic disease.

Authors:
Debra S Heller

APMIS 2018 Jul;126(7):647-654

Department of Pathology & Laboratory Medicine, Rutgers-New Jersey Medical School, Newark, NJ, USA.

Gestational trophoblastic disease can be a challenging area for pathologic evaluation. An update with a focus on pathologic challenges is presented. Read More

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July 2018
17 Reads

Multiple metastatic gestational trophoblastic disease after a twin pregnancy with complete hydatidiform mole and coexisting fetus, following assisted reproductive technology: Case report and literature review.

Taiwan J Obstet Gynecol 2018 Aug;57(4):588-593

Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, Kashihara-City, Nara-Prefecture, 634-8522, Japan.

Objective: Twin pregnancy with complete hydatidiform mole and coexisting fetus (CHMCF) is rare and associated with severe complications during pregnancy and subsequent gestational trophoblastic disease (GTD). We encountered a case of multiple metastatic GTD after a twin pregnancy with CHMCF, following conventional in vitro fertilization (IVF). Only one case of metastatic GTD after CHMCF due to assisted reproductive technology (ART) has been reported. Read More

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August 2018
8 Reads

Hyperthyroidism in a complete molar pregnancy with a mature cystic ovarian teratoma.

Thyroid Res 2018 10;11:12. Epub 2018 Aug 10.

Nature Coast Healthcare Center, Tallahassee, FL USA.

Background: The hallmark of gestational trophoblastic disease is the production of human chorionic gonadotropin (hCG) due to the hyperproliferation of extraembryonic trophoblast cells. Previous studies show hCG has thyrotropic action due to its structural similarity with thyroid stimulating hormone (TSH) molecules. Germ cell tumors represent 15-20% of all ovarian tumors and can be malignant or benign. Read More

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August 2018
13 Reads

[Clinical application of STR genotyping diagnosis for hydatidiform mole and nonmolar gestation].

Zhonghua Bing Li Xue Za Zhi 2018 Aug;47(8):609-615

Department of Pathology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100006, China.

To investigate the value of short tandem repeat (STR) genotyping in the diagnostic workup of molar and non-molar gestations with correlation of histological characteristics. Six hundred and fifty-six cases were selected based on clinically suspected hydropic abortion and/or molar pregnancy from July 2015 to September 2017 at Beijing Obstetrics and Gynecology Hospital. DNA was extracted from dissected chorionic villi and paired maternal endometrial FFPE tissue samples by Simplex OUP™ FFPE DNA Tissue Kit. Read More

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August 2018
2 Reads

Genetics, molar pregnancies and medieval ideas of monstrous births: the lump of flesh in .

Med Humanit 2018 Aug 7. Epub 2018 Aug 7.

Department of Human Genetics and Genomics Medicine, Faculty of Medicine, University of Southampton, Southampton, UK.

The medieval English romance gives an account of a birth of a lump of flesh. This has been considered as fantastic and monstrous in past literature, the horrific union of a Christian and Saracen. However, while the text certainly speaks to miscegenation, we propose that this lump of flesh is actually a hydatidiform mole. Read More

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August 2018
2 Reads

Sudden death due to an invasive mole in a young primigravida: Precipitous presentation masquerading the natural manner.

Med Sci Law 2018 Jul 3;58(3):189-193. Epub 2018 Jul 3.

3 Department of Forensic Medicine, Maulana Azad Medical College, New Delhi, India.

Pulmonary metastasis is a well-known complication of an invasive mole. However, sudden death due to haemoptysis resulting from a metastatic invasive mole is extremely rare. We report the sudden unexpected death of an 18-year-old primigravida following a molar pregnancy. Read More

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July 2018
35 Reads
0.760 Impact Factor

[Clinical significance of centralized surveillance of hydatidiform mole].

Zhonghua Fu Chan Ke Za Zhi 2018 Jun;53(6):390-395

Department of Gynecology Oncology, Dalian Maternal and Child Health Care Hospital, Dalian Obstetrics and Gynecology Hospital Affiliated to Dalian Medical University, Dalian 116033, China.

To explore the clinical significance of centralized surveillance of hydatidiform mole. From Feb. 2013 to Feb. Read More

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June 2018
13 Reads

Removal of retained products of conception showing marked vascularity without uterine artery embolization: Two case reports.

J Obstet Gynaecol Res 2018 Aug 28;44(8):1482-1486. Epub 2018 Jun 28.

Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.

Retained products of conception with marked vascularity can cause massive postabortal or post-partum bleeding. Uterine artery embolization is effective for uterus preservation but does not assure fertility preservation. Thus, the optimal treatment for retained products of conception with marked vascularity is uncertain. Read More

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August 2018
10 Reads

Partial molar pregnancy in the cesarean scar: A case report and literature review.

Medicine (Baltimore) 2018 06;97(26):e11312

Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China.

Rationale: The incidence of molar pregnancy in the cesarean scar is exceedingly low, however, the disease may carry a high risk of uncontrolled hemorrhage or uterine rupture. So far managements of this disease were rarely reported in literature.

Patient Concerns: We reported a 28-year-old woman presented to our hospital with a complaint of amenorrhea for 48 days and vaginal bleeding for 3 days. Read More

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June 2018
7 Reads

A bioinformatics transcriptome meta-analysis highlights the importance of trophoblast differentiation in the pathology of hydatidiform moles.

Placenta 2018 May 7;65:29-36. Epub 2018 Apr 7.

University Paris Saclay Saint-Aubin, France; INSERM U1197 Stem Cell-Niches Interactions: Physiology, Tumors and Tissular Repair, Hospital Paul Brousse, Bâtiment Lavoisier, Villejuif, France. Electronic address:

Introduction: Hydatidiform mole (HM) is an aberrant human pregnancy with abnormal trophoblastic development, migration/invasion of the extravillous trophoblast in the decidua. These abnormalities are established in a hypoxic environment during the first trimester of gestation.

Methods: Using text mining, we identified 72 unique genes that are linked to HM (HM-linked genes) that we studied by bioinformatic analysis in publicly available transcriptomes of primary chorionic villous cells (cytotrophoblast, syncytiotrophoblast, extravillous trophoblast, and arterial and venous endothelial) isolated from normal placentas or established trophoblastic cell lines cultured under different oxygen concentrations. Read More

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May 2018
11 Reads

p57 immunostaining for diagnosis of hydatidiform mole.

Authors:
B Kaur N J Sebire

BJOG 2018 Sep 18;125(10):1234. Epub 2018 Jul 18.

Great Ormond Street Hospital, London, WC1N 3JH, UK.

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September 2018
9 Reads

First-line hysterectomy for women with low-risk non-metastatic gestational trophoblastic neoplasia no longer wishing to conceive.

Gynecol Oncol 2018 08 8;150(2):282-287. Epub 2018 Jun 8.

University of Lyon 1, University Hospital Lyon Sud, Department of Gynecological Surgery and Oncology, Obstetrics, Pierre Bénite, France; French Center for Trophoblastic Diseases, University Hospital Lyon Sud, Pierre Bénite, France. Electronic address:

Background: Low-risk gestational trophoblastic neoplasia (GTN) patients (FIGO score ≤6) are generally treated with single agent chemotherapy (methotrexate or dactinomycin) resulting in a 5-year mortality rate of 0.3%. However, despite these encouraging survival rates, chemotherapy is associated with significant adverse events in most patients. Read More

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August 2018
11 Reads

Invasive hydatidiform mole in the cervix.

Pan Afr Med J 2018;29:27. Epub 2018 Jan 12.

Centre Hospitalier Universitaire Ibn Rochd, Faculté de Médecine et Pharmacie, Hassan II University of Casablanca, Casablanca, Maroc.

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January 2018
2 Reads

Live euploid birth and complete hydatid mole, followed by partial hydatid mole after ICSI.

J Assist Reprod Genet 2018 Aug 2;35(8):1533-1536. Epub 2018 Jun 2.

Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

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August 2018
1 Read

Choriocarcinoma with multiple lung metastases from complete hydatidiform mole with coexistent fetus during pregnancy.

J Obstet Gynaecol Res 2018 Aug 29;44(8):1476-1481. Epub 2018 May 29.

Department of Obstetrics and Gynecology, Kobe City Medical Center General Hospital, Kobe, Japan.

Gestational trophoblastic neoplasm (GTN) is a serious morbidity of complete hydatidiform mole with coexistent fetus (CHMCF) and usually develops after termination of pregnancy. Here we report a case of choriocarcinoma derived from CHMCF during pregnancy. A 33-year-old multiparous woman with suspected CHMCF was admitted with a severe cough. Read More

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August 2018
5 Reads

Prevalence and Factors Associated with Hydatidiform Mole among Patients Undergoing Uterine Evacuation at Mbarara Regional Referral Hospital.

Obstet Gynecol Int 2018 1;2018:9561413. Epub 2018 Apr 1.

Makerere University, Kampala, Uganda.

Objective: We sought to determine the prevalence of and factors associated with hydatidiform molar gestations amongst patients undergoing uterine evacuation at Mbarara Regional Referral Hospital (MRRH), Mbarara, Uganda.

Methods: This was a cross-sectional study carried out from November 2016 to February 2017. All patients admitted for uterine evacuation for nonviable pregnancy were included. Read More

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April 2018
13 Reads

Invasive molar pregnancy in rudimentary uterine horn.

J Exp Ther Oncol 2018 May;12(3):207-210

Department of Obstetrics and Gynecology, Dr. Zekai Tahir Burak Women's Health Research and Practice Center, University of Health Sciences, Ankara, Turkey.

Objective: Incidence of molar pregnancy is 1-3/1000 pregnancies. Invasive mole is a local invasive form of gestational trophoblastic neoplasias which is mostly seen in reproductive age and usually follows a molar pregnancy and rarely has an initial presentation. Ectopic pregnancy in rudimentary uterine horn is extremely rare and is seen in 1/100,000 - 140,000 pregnancies. Read More

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May 2018
3 Reads

Accuracy of p57 compared with genotyping to diagnose complete hydatidiform mole: a systematic review and meta-analysis.

BJOG 2018 Sep 15;125(10):1226-1233. Epub 2018 Jun 15.

Department of Public Health, Federal University of Health Science - UFCSPA, Porto Alegre, Brazil.

Background: Distinguishing hydatidiform moles (HMs) from nonmolar specimens and the subclassification of HM are important because complete hydatidiform mole (CHM) is associated with an increased risk of development of gestational trophoblastic neoplasia. However, diagnosis based solely on morphology has poor inter-observer reproducibility. Recent studies have demonstrated that the use of p57 immunostaining improves diagnostic accuracy for CHM. Read More

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September 2018
3 Reads

Molar pregnancy with normal viable fetus presenting with severe pre-eclampsia: a case report.

J Med Case Rep 2018 May 21;12(1):140. Epub 2018 May 21.

Department of Obstetrics & Gynecology Miri General Hospital, Sarawak, Malaysia.

Background: While gestational trophoblastic disease is not rare, hydatidiform mole with a coexistent live fetus is a very rare condition occurring in 0.005 to 0.01% of all pregnancies. Read More

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May 2018
3 Reads

Gestational Trophoblastic Neoplasia after Ectopic Molar Pregnancy: Clinical, Diagnostic, and Therapeutic Aspects.

Rev Bras Ginecol Obstet 2018 May 16;40(5):294-299. Epub 2018 May 16.

Department of Pathology, Universidade Federal Fluminense, Niterói, RJ, Brazil.

This report presents the case of a patient with gestational trophoblastic neoplasia after a partial hydatidiform mole formed in the Fallopian tube. Ectopic molar pregnancy is a rare condition, with an estimated incidence of 1 in every 20,000 to 100,000 pregnancies; less than 300 cases of it have been reported in the Western literature. The present report is important because it presents current diagnostic criteria for this rare condition, which has been incorrectly diagnosed in the past, not only morphologically but also immunohistochemically. Read More

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May 2018
5 Reads

Recurrent complete hydatidiform mole: where we are, is there a safe gestational horizon? Opinion and mini-review.

J Assist Reprod Genet 2018 Jun 8;35(6):967-973. Epub 2018 May 8.

3rd Department of Obstetrics and Gynaecology, Hippokration General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Benign hydatidiform mole, complete or partial, is the most common type of gestational trophoblastic disease (GTD) characterised by excessive trophoblastic proliferation and abnormal embryonic development. Although most complete hydatidiform moles (CHMs) are diploid androgenetic, a few cases of CHMs are biparental, characterised by recurrence and familial clustering. In these rare cases, mutations in NLRP7 or KHDC3L genes, associated with maternal imprinting defects, have been implicated. Read More

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June 2018
2 Reads

Biallelic PADI6 variants linking infertility, miscarriages, and hydatidiform moles.

Eur J Hum Genet 2018 Jul 25;26(7):1007-1013. Epub 2018 Apr 25.

Department of Human Genetics, McGill University Health Centre, Montreal, QC, Canada.

Recurrent hydatidiform moles (RHM) are aberrant human pregnancies characterized by absence of, or abnormal, embryonic development, hydropic degeneration of chorionic villi, and hyperproliferation of the trophoblast. Biallelic mutations in two maternal-effect genes, NLRP7 and KHDC3L, underlie the causation of RHM in 60% of patients. We performed exome sequencing on a patient with six pregnancy losses, two miscarriages and four HM, and found no variants that affect the functions of the known genes. Read More

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July 2018
5 Reads

A 34-Week Size Uterus with a Complete Hydatidiform Mole: Hook Effect and Severe Anemia with No Vaginal Bleeding.

Case Rep Obstet Gynecol 2018 13;2018:8201949. Epub 2018 Feb 13.

Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical Center, New York, NY 10021, USA.

Complete hydatidiform mole is an abnormal pregnancy that usually presents with vaginal bleeding and markedly elevated serum ß-hCG levels. We report a rare case of complete hydatidiform mole occurring in a 16-year-old nulligravid who presented with a 34-week size uterus and a relatively low serum ß-hCG level (722 IU/L)-likely related to the "hook effect"-and severe anemia (hemoglobin: 6.1 g/dL) despite the absence of vaginal bleeding. Read More

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February 2018

Identification of nonsynonymous TP53 mutations in hydatidiform moles.

Mutat Res 2018 May 29;809:20-23. Epub 2018 Mar 29.

Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China. Electronic address:

Hydatidiform mole (HM), an unusual pregnancy with pure or predominant paternal genetic contribution, is the most common form of gestational trophoblastic disease. Most HM regress after uterine evacuation but some will develop into persistent disease or even frank malignancy. Although p53 is highly expressed in HM, TP53 mutations have rarely been detected in previous studies. Read More

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May 2018
6 Reads

Hysteroscopic Management of Partial Hydatidiform Mole: A Novel Approach to an Old Disease.

J Minim Invasive Gynecol 2018 Apr 6. Epub 2018 Apr 6.

University of Miami, Miami, Florida. Electronic address:

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April 2018
5 Reads

[Clinical and radiological features of gestational trophoblastic tumors].

Pan Afr Med J 2017 14;28:228. Epub 2017 Nov 14.

Service de Gynécologie Obstétrique I, Hôpital Mère Enfant, CHU Hassan II, Fès, Université sidi Mohamed ben Abdellah, Maroc.

Gestational trophoblastic disease incorporates a group of diseases which differ from each other by their regressive evolution, their evolution to metastasis and to recurrence. It is a severe disease that affects women of childbearing age. Gestational trophoblastic tumors (GTT) are the malignant forms of gestational trophoblastic diseases. Read More

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May 2018
3 Reads

Diagnostic Utility of Twist1, Ki-67, and E-Cadherin in Diagnosing Molar Gestations and Hydropic Abortions.

Am J Clin Pathol 2018 Mar;149(5):442-455

Department of Obstetrics & Gynecology, Faculty of Medicine, Minia University, Minia, Egypt.

Objectives: This study aims to assess whether the expression of Twist1, Ki-67, and E-cadherin can guide the differential diagnosis of complete hydatidiform mole (CHM), partial hydatidiform mole (PHM), and hydropic abortion (HA).

Methods: Differential expression of Twist1, Ki-67, and E-cadherin was analyzed in gestational products from 55 cases of CHM, PHM, and HA using immunohistochemistry. Prior to analysis, the studied cases were confirmed for their diagnosis by flow cytometric assessment of DNA ploidy and p57 immunostaining. Read More

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March 2018
6 Reads

Does a human chorionic gonadotropin level of over 20,000 IU/L four weeks after uterine evacuation for complete hydatidiform mole constitute an indication for chemotherapy for gestational trophoblastic neoplasia?

Eur J Obstet Gynecol Reprod Biol 2018 Apr 15;223:50-55. Epub 2018 Feb 15.

Charing Cross Gestational Trophoblastic Disease Centre, Charing Cross Hospital, Imperial College of London, London, UK.

Objective: To evaluate whether a human chorionic gonadotropin (hCG) level ≥20,000 IU/L four weeks after uterine evacuation for complete hydatidiform mole (CHM) is an appropriate indicator for initiating chemotherapy for the treatment of gestational trophoblastic neoplasia (GTN).

Study Design: Historical database review of 1228 women with CHM who received treatment and follow-up between January 2000 and June 2013 at four Brazilian trophoblastic disease centers. The primary outcome measure was the progression from CHM to GTN. Read More

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April 2018
6 Reads

The genetics of recurrent hydatidiform moles: new insights and lessons from a comprehensive analysis of 113 patients.

Mod Pathol 2018 Jul 20;31(7):1116-1130. Epub 2018 Feb 20.

Departments of Human Genetics, McGill University Health Centre, Montreal, Quebec, Canada.

Hydatidiform mole is an aberrant human pregnancy characterized by early embryonic arrest and excessive trophoblastic proliferation. Recurrent hydatidiform moles are defined by the occurrence of at least two hydatidiform moles in the same patient. Fifty to eighty percent of patients with recurrent hydatidiform moles have biallelic pathogenic variants in NLRP7 or KHDC3L. Read More

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July 2018
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Clinical and genetic-epignetic aspects of recurrent hydatidiform mole: A review of literature.

Taiwan J Obstet Gynecol 2018 Feb;57(1):1-6

Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Hydatidiform Mole (HM) is the most common form of Gestational Trophoblastic Disease (GTD), defined by hyper-proliferation of trophoblastic cells. HM is typified as abnormal proliferation of extraembryonic trophoblastic (placental) tissues and failure of embryonic tissues development and is the only GTD with Mendelian inheritance, which can reoccur in different pregnancies. Moles are categorized into Complete Hydatidiform Moles (CHM) or Partial Hydatidiform Moles (PHM) and a rare familial trait, which forms a CHM and despite having androgenetic pattern, shows normal biparental inheritance, conceived from one sperm and egg. Read More

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February 2018
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Temporal trends in incidence and outcome of hydatidiform mole: a retrospective cohort study.

Acta Oncol 2018 Aug 16;57(8):1094-1099. Epub 2018 Feb 16.

e Department of Clinical Science and Education, Division of Obstetrics and Gynaecology , Karolinska Institutet Södersjukhuset , Stockholm , Sweden.

Background: Reported incidence rates of hydatidiform mole (HM) show wide geographic and temporal variations, making reliable international comparisons difficult. The aim of the current study was to examine temporal trends in the incidence of HM and post-molar gestational trophoblastic neoplasia (GTN) in Stockholm County.

Material And Methods: Data of all women with a diagnosis of HM in Stockholm County 1991-2010 was collected. Read More

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August 2018
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