5,768 results match your criteria Hydatidiform Mole

A Rare Case of Early Transformation of Gestational Trophoblastic Neoplasia Following Molar Pregnancy.

Am J Case Rep 2021 May 11;22:e930789. Epub 2021 May 11.

Department of Obstetrics and Gynecology, Faculty of Medicine, Padjadjaran University - Dr. Hasan Sadikin Hospital, Bandung, Indonesia.

BACKGROUND Gestational trophoblastic disease (GTD) encompasses a group of disorders that arise from abnormal growth of trophoblastic tissue. The spectrum of GTD includes 2 major groups: benign and malignant. The benign form is a hydatidiform mole, either complete or partial; the malignant forms, referred to as gestational trophoblastic neoplasia (GTN), consist of invasive moles, choriocarcinomas, placental site trophoblastic tumors, and epithelioid trophoblastic tumors. Read More

View Article and Full-Text PDF

Cytological features of a complete hydatidiform mole in a cervicovaginal smear: A case report.

Diagn Cytopathol 2021 May 7. Epub 2021 May 7.

Department of Histopathology, The Indus Hospital, Karachi, Pakistan.

Exfoliated trophoblastic cells can be seen in a cervicovaginal smear in cases of normal pregnancy or gestational trophoblastic disease (GTD) and can mimic high-grade squamous intraepithelial lesion (HSIL) or malignancy. Although they appear highly anaplastic, cytological features such as high nuclear to cytoplasmic ratio, irregular nuclear contours and scanty basophilic cytoplasm admixed with cytologically benign squamoid and endocervical cells can aid in differentiating them from malignant cells. We present a case of a 37-year-old woman with abnormal uterine bleeding for 3-months. Read More

View Article and Full-Text PDF

Rare Complete Hydatidiform Mole With p57 Expression in Villous Mesenchyme: Case Report and Review of Discordant p57 Expression in Hydatidiform Moles.

Int J Gynecol Pathol 2021 Apr 23. Epub 2021 Apr 23.

ProPath (K.M.M.) Department of Obstetrics and Gynecology (V.R. and D.H.C.) Department of Pathology, Division of Cytogenetics (P.K.) Department of Pathology, Division of Gynecologic Pathology (K.C., K.G., and D.H.C.), UT Southwestern Medical Center, Dallas, Texas Departments of Pathology and Gynecology & Obstetrics, The Johns Hopkins Medical Institutions, Baltimore, Maryland (B.M.R.).

Complete hydatidiform mole (CHM) is a premalignant proliferative disease of the placenta characterized by misexpression of imprinted gene products, most notably p57. The majority of CHM exhibit immunohistochemical absence of p57 protein in villous mesenchyme (VM) and cytotrophoblast (CT) and are thus p57 VM/CT concordant. However, some gestations show loss of p57 in only VM or CT, either in all chorionic villi or a subset thereof (VM/CT discordant). Read More

View Article and Full-Text PDF

Trajectory clustering using mixed classification models.

Stat Med 2021 Apr 7. Epub 2021 Apr 7.

Université de Lyon, Lyon, France.

Trajectory classification has become frequent in clinical research to understand the heterogeneity of individual trajectories. The standard classification model for trajectories assumes no between-individual variance within groups. However, this assumption is often not appropriate, which may overestimate the error variance of the model, leading to a biased classification. Read More

View Article and Full-Text PDF

Normalisation of human chorionic gonadotrophin (hCG) levels in a patient with partial molar pregnancy with a uterine mass without chemotherapy: impact of using herbal remedies.

J Complement Integr Med 2021 Apr 2. Epub 2021 Apr 2.

School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia.

Objectives: Level of βhCG and the presence of any uterine mass of hydatidiform mole need a careful review or monitoring in order to prevent metastasis, provide an early treatment and avoid unnecessary chemotherapy.

Case Presentation: A 36-year old fifth gravida patient who had a missed abortion was diagnosed as having a molar pregnancy with beta human chorionic gonadotrophin (βhCG) level of 509,921 IU/L. Her lung field was clear and she underwent suction and curettage (S & C) procedure. Read More

View Article and Full-Text PDF

A unique case of recurrent fetal cystic hygroma: first fetus with an inherited heteromorphism of chromosome 1 (1qh+) and the second fetus with 69XXX triploidy.

Rom J Morphol Embryol 2020 Jul-Sep;61(3):935-940

Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania; Department of Internal Medicine, Faculty of Medicine, Ovidius University of Constanţa, Romania;

The authors report a unique recurrent septated cystic hygroma (CH), on two successive pregnancies, at five years interval. The chromosome analysis of the first fetus showed an increase in length of heterochromatin on the long arm of chromosome 1 - 1qh+, a chromosomal polymorphism inherited from mother, 46XX,1qh+,14ps+,21ps+. The karyotype of the second CH, with more severe ultrasound (US) imaging, showed a 69XXX triploidy. Read More

View Article and Full-Text PDF

Association of Placental Mesenchymal Dysplasia With a Live Female Fetus and Complete Hydatidiform Mole: Report of a Challenging Case Confirmed by Molecular Genotyping Analysis.

Int J Gynecol Pathol 2021 Apr 1. Epub 2021 Apr 1.

Departments of Pathology (A. Hamard, A. Heitzmann) Gynecology and Obstetrics (C.C., C.D.), Orleans Regional Hospital, Orléans Department of Pathology (C.M., L.G.-D., F.A.) French Reference Center for Gestational Trophoblastic Diseases, Hospices Civils de Lyon, Lyon Sud University Hospital, Pierre-Bénite (L.G.-D., T.H., J.M., F.A.) Department of Gynecology and Obstetrics, Hospices Civils de Lyon, Femme Mère Enfant University Hospital, Bron (J.M.) Perinatality Center, Pithiviers General Hospital, Pithiviers (C.C., R.V.), France.

Placental mesenchymal dysplasia (PMD) and complete hydatidiform mole (CHM) with a coexisting fetus are 2 rare placental abnormalities characterized by lacunar placenta and presence of an embryo on ultrasound examination. We report the case of a 34-yr-old woman referred at 32.6 weeks of gestation because of a multicystic placenta. Read More

View Article and Full-Text PDF

First-trimester miscarriage: A histopathological classification proposal.

Heliyon 2021 Mar 8;7(3):e06359. Epub 2021 Mar 8.

School of Medicine, University of Minho, Surgical Sciences Domain Research, Campus de Gualtar, 4710-057, Braga, Portugal.

Background: Histopathology of first-trimester abortion products may be useful in document an intrauterine pregnancy, identifying an important pathology affecting the mother or the embryo and diagnosing conditions that are likely to recur in future pregnancies or that explain the adverse fetal outcome. Relevant information provided by histology is essential to determine the cause and to guide the patients with early pregnancy failure.

Aims: Histopathological classification proposal in first-trimester miscarriage. Read More

View Article and Full-Text PDF

"While there is p57, there is hope." The past and the present of diagnosis in first trimester abortions: Diagnostic dilemmas and algorithmic approaches. A review.

Placenta 2021 Feb 25. Epub 2021 Feb 25.

Department of Medicine - Pathology & Cytopathology Unit, Padua University Hospital, Via Giustiniani, 2 - 35121 Padua, Italy. Electronic address:

Distinction of hydatidiform moles (HM) from non-molar (NM) specimens and subclassification of HM as complete hydatidiform mole (CHM) versus partial hydatidiform mole (PHM) are important for clinical practice and investigational studies. The issue of diagnostic reproducibility is still unsolved, the lack of diagnostic accuracy based on morphology is substantial with an important interobserver variability, even between experienced gynecologic pathologists. Many ancillary techniques have been investigated in the last years to refine HM diagnosis. Read More

View Article and Full-Text PDF
February 2021

A possible association between hydatidiform mole and the COVID-19 pandemic: A retrospective cohort study.

Gynecol Oncol 2021 05 5;161(2):454-457. Epub 2021 Mar 5.

Department of Obstetrics and Gynecology, Galilee Medical Centre, Nahariya, Israel; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel. Electronic address:

Objective: To confirm an increase in the number of women with molar pregnancy during the COVID-19 pandemic.

Methods: In this retrospective cohort study, all patients with complete or partial mole diagnosed at our institution between January 1, 2010 and October 31, 2020, were included. To verify whether there was an increase in the incidence of hydatidiform mole (HM) and deliveries in 2020, the incidences for each year from January 2010 to October 2020 were recorded. Read More

View Article and Full-Text PDF

An integrated model of preeclampsia: a multifaceted syndrome of the maternal cardiovascular-placental-fetal array.

Am J Obstet Gynecol 2021 Mar 9. Epub 2021 Mar 9.

Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Maternal tolerance of the semiallogenic fetus necessitates conciliation of competing interests. Viviparity evolved with a placenta to mediate the needs of the fetus and maternal adaptation to the demands of pregnancy and to ensure optimal survival for both entities. The maternal-fetal interface is imagined as a 2-dimensional porous barrier between the mother and fetus, when in fact it is an intricate multidimensional array of tissues and resident and circulating factors at play, encompassing the developing fetus, the growing placenta, the changing decidua, and the dynamic maternal cardiovascular system. Read More

View Article and Full-Text PDF

Spermatogonium-Derived Complete Hydatidiform Mole.

N Engl J Med 2021 03;384(10):936-943

From the Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.

A complete hydatidiform mole (CHM) is a conceptus with only sperm-derived chromosomes. Here, we report on a CHM with genomic DNA identical to that of the paternal somatic cells. The CHM developed in a woman who had undergone intrauterine implantation of a blastocyst obtained through in vitro injection of a presumed round spermatid into one of her oocytes. Read More

View Article and Full-Text PDF

Genetics of gestational trophoblastic disease.

Best Pract Res Clin Obstet Gynaecol 2021 Feb 2. Epub 2021 Feb 2.

Trophoblastic Tumour Screening and Treatment Centre, Faculty of Medicine, Imperial College London, Charing Cross Campus, Fulham Palace Road, London, W6 8RF, UK.

The abnormal pregnancies complete and partial hydatidiform mole are genetically unusual, being associated with two copies of the paternal genome. Typical complete hydatidiform moles (CHMs) are diploid and androgenetic, while partial hydatidiform moles (PHMs) are diandric triploids. While diagnosis can usually be made on the basis of morphology, ancillary techniques that exploit their unusual genetic origin can be used to facilitate diagnosis. Read More

View Article and Full-Text PDF
February 2021

Fertility and pregnancy outcome in gestational trophoblastic disease.

Int J Gynecol Cancer 2021 Mar;31(3):399-411

Department of Gynecologic Oncology, Netherlands Cancer Institute, Amsterdam, Noord-Holland, The Netherlands.

The aim of this review is to provide an overview of existing literature and current knowledge on fertility rates and reproductive outcomes after gestational trophoblastic disease. A systematic literature search was performed to retrieve all available studies on fertility rates and reproductive outcomes after hydatidiform mole pregnancy, low-risk gestational trophoblastic neoplasia, high- and ultra-high-risk gestational trophoblastic neoplasia, and the rare placental site trophoblastic tumor and epithelioid trophoblastic tumor forms of gestational trophoblastic neoplasia. The effects of single-agent chemotherapy, multi-agent including high-dose chemotherapy, and immunotherapy on fertility, pregnancy wish, and pregnancy outcomes were evaluated and summarized. Read More

View Article and Full-Text PDF

KH domain containing 3 like (KHDC3L) frame-shift mutation causes both recurrent pregnancy loss and hydatidiform mole.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 10;259:100-104. Epub 2021 Feb 10.

Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Electronic address:

Objective: Recurrent pregnancy loss (RPL) is a common infertility-related complication that affects approximately 1-3 % of women worldwide. Known causes of etiology are found in approximately half the cases but the other half remain unexplained. It is estimated that several thousands of genes contribute to reproductive success in mammals and the genetic causes of RPL cannot be fully addressed through targeted genetic tests. Read More

View Article and Full-Text PDF

Molar Changes With a Normal Viable Fetus: A Case Report.

J Family Reprod Health 2020 Sep;14(3):205-208

Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

The presence of a normal fetus with normal karyotype accompanied by molar changes in the placenta is a rare condition, which carries a significant risk to the mother and fetus. There is a controversy regarding the proper management of this condition. Here, we present the case of a singleton pregnancy that showed molar changes in the pathological study of the placenta, but ended up with a normal viable neonate. Read More

View Article and Full-Text PDF
September 2020

Educational Case: Hydatidiform Molar Pregnancy.

Acad Pathol 2021 Jan-Dec;8:2374289520987256. Epub 2021 Jan 28.

Eastern Virginia Medical School, Norfolk, VA, USA.

http://journals.sagepub.com/doi/10. Read More

View Article and Full-Text PDF
January 2021

Importance of the genetics in the diagnostics of hydatidiform mole.

Ceska Gynekol 2020 ;85(4):275-281

Objective: To summarize the possibilities of the genetic analysis of hydatidiform moles and point out its perspectives in the diagnostics of this disease.

Design: Review.

Setting: Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University in Bratislava, Slovak Republic. Read More

View Article and Full-Text PDF
February 2021

Video Hysteroscopy in the Diagnosis of Molar Pregnancy in two Challenging Situations: Complete Mole with Normal hCG and Partial Mole with Early Gestational Age.

J Minim Invasive Gynecol 2021 Feb 6. Epub 2021 Feb 6.

New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (Drs. Elias, Horowitz, and Berkowitz).

Study Objective: To present the first hysteroscopic findings of 2 cases of complete hydatidiform mole (CHM) and partial hydatidiform mole (PHM) within the context of the patients' clinical histories.

Design: Presentation of 2 hysteroscopic videos with narration of the intrauterine findings of molar pregnancy (MP) from Rio de Janeiro Gestational Trophoblastic Disease Reference Center.

Setting: MP is characterized by abnormal fertilization that generates 2 clinical syndromes: CHM and PHM [1]. Read More

View Article and Full-Text PDF
February 2021

Obstetrics outcomes after complete and partial molar pregnancy: Review of the literature and meta-analysis.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 29;259:18-25. Epub 2021 Jan 29.

Department of Gynecology and Obstetrics, University of Parma, Via Gramsci, 43125, Parma, Italy.

The hydatidiform mole is a rare gynecological disease rising from the trophoblastic. Post-molar pregnancies have an extremely variable course, varying from repeated abortions, stillbirths, preterm births, live births, or recurring in further molar pregnancies. Literature on obstetric outcomes following molar pregnancy is poor, often including monocentric studies, and with data collected from national databases. Read More

View Article and Full-Text PDF

Incidental diagnosis of sad fetus syndrome in triplets.

BMJ Case Rep 2021 Feb 4;14(2). Epub 2021 Feb 4.

Pathology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka, India.

An unusual presentation of gestational trophoblastic disease is twin molar pregnancy, rarest in triplets with differentials being partial/complete mole, placental mesenchymal dysplasia (PMD), placental cysts or chorioangioma each with different complications. Counselling to continue pregnancy depends on diagnosis. A 37-year-old GPL, donor oocyte In vitro fertlisation (IVF) twin pregnancy was referred at 24 weeks with cystic areas in placenta. Read More

View Article and Full-Text PDF
February 2021

Emergency craniotomy in patient with intracranial metastatic choriocarcinoma: a case report.

J Int Med Res 2021 Feb;49(2):300060520987725

Department of Obstetrics and Gynaecology, The First Affiliated Hospital of University of Science & Technology of China, Anhui Provincial Hospital, Hefei, Anhui Province, China.

Choriocarcinoma is a highly malignant gynaecological tumour. This disease becomes life-threatening once brain haemorrhage or brain herniation occurs. Timely and accurate brain surgery can gain treatment time for patients that have a large number of cerebral haemorrhages and/or brain herniation. Read More

View Article and Full-Text PDF
February 2021

A New Stepwise Molecular Work-Up After Chorionic Villi Sampling in Women With an Early Pregnancy Loss.

Front Genet 2020 14;11:561720. Epub 2021 Jan 14.

BCNatal Department of Maternal-Fetal Medicine, Institute Gynecology, Obstetrics and Neonatology, Hospital Clínic de Barcelona, Barcelona, Spain.

To explore the use of a new molecular work-up based on the stepwise use of Quantitative Fluorescence PCR (QF-PCR) extended to eight chromosomes and single nucleotide polymorphism array (SNP-array) in chorionic villi obtained by chorionic villi sampling (CVS) offered to women experiencing an early pregnancy loss. During a 3-year period (January 2016-December 2018), CVS was offered to women experiencing an early pregnancy loss before the evacuation of the products of conception (POC) to retrieve chorionic villi, irrespective of the number of previous losses. A new molecular work-up was prospectively assayed encompassing a first QF-PCR round (with the 21, 18, 13, 7, X, and Y chromosomes), a second QF-PCR round (with the 15, 16, and 22 chromosomes), and a high resolution SNP-array in those cases with normal QF-PCR results. Read More

View Article and Full-Text PDF
January 2021

[Persistent gestational trophoblastic disease following ectopic molar pregnancy].

Arkh Patol 2021 ;83(1):44-48

Moscow Regional Research Institute of Obstetrics and Gynecology of the Ministry of Health of the Moscow Region, Moscow, Russia.

A case of persistent gestational trophoblastic disease that developed after ectopic (cervical) pregnancy with complete hydatidiform mole (CHM) in a 56-year-old patient is presented. The diagnosis of CHM was made retrospectively based on immunohistochemical analysis of archival material using p57 and Ki67 antibodies. Observation shows the difficulty of objective diagnosis of hydatidiform mole in early pregnancy due to the lack of typical cystic transformation of the stroma of villi, focal proliferation of villous trophoblast. Read More

View Article and Full-Text PDF
February 2021

Management of a complete hydatidiform mole with a coexisting live fetus followed by successful treatment of maternal metastatic gestational trophoblastic disease: learning points.

BMJ Case Rep 2021 Jan 18;14(1). Epub 2021 Jan 18.

Division of Obstetrics and Gynaecology, Department of Obstetrics and Gynaecology, KK Women's and Children's Hospital, Singapore.

A 34-year-old patient had her first trimester Down syndrome scan followed by serial ultrasound scans which showed a single intrauterine pregnancy with multiple cystic areas in the anterior placenta. She presented in preterm labour with a breech presentation at 32 weeks and underwent an emergency caesarean section. She delivered a male infant weighing 1750 g. Read More

View Article and Full-Text PDF
January 2021

Psychological factors influencing emotional reactions to gestational trophoblastic disease: The role of coping mechanisms and illness perception.

Eur J Cancer Care (Engl) 2021 Jan 18:e13404. Epub 2021 Jan 18.

Obstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Objective: Referring to Leventhal's common-sense model, this observational cross-sectional study aimed at investigating the relationship between illness mental representations, coping mechanisms and psychological distress in a sample of women with gestational trophoblastic disease (GTD).

Methods: Thirty-eight women diagnosed with GTD (18 with hydatidiform mole; 20 with gestational trophoblastic neoplasia) were asked to complete the Illness Perception Questionnaire-Revised, the Coping Orientation to the Problems Experienced, the State-Trait Anxiety Inventory-Form Y and the Beck Depression Inventory-Short Form. Demographic and clinical information was collected through a self-report questionnaire. Read More

View Article and Full-Text PDF
January 2021

An invasive mole with pulmonary metastases in a 55-year-old postmenopausal Syrian woman: a case report and review of the literature.

J Med Case Rep 2021 Jan 18;15(1):13. Epub 2021 Jan 18.

Department of Pathology, Cancer Research Centre, Faculty of Medicine, Tishreen University, Lattakia, Syria.

Background: Invasive mole is a subtype of gestational trophoblastic neoplasms (GTNs) that usually develops from the malignant transformation of trophoblastic tissue after molar evacuation. Invasive moles mostly occur in women of reproductive age, while they are extremely rare in postmenopausal women.

Case Presentation: We present the case of a 55-year-old postmenopausal Syrian woman who was admitted to the emergency department at our hospital due to massive vaginal bleeding for 10 days accompanied by constant abdominal pain with diarrhea and vomiting. Read More

View Article and Full-Text PDF
January 2021

Recurrent GTD and GTD coexisting with normal twin pregnancy.

Neil J Sebire

Best Pract Res Clin Obstet Gynaecol 2020 Dec 21. Epub 2020 Dec 21.

Trophoblastic Disease Unit, Department of Histopathology, Charing Cross Hospital Imperial Nhs Trust, London, UK. Electronic address:

Hydatidiform mole (HM) affects around 1/1000 pregnancies, and in such cases the recurrence risk is around 1%, being greater for those with complete HM (CHM). Whilst most cases appear sporadic with unknown mechanisms, there is a distinct subgroup of patients who suffer recurrent pregnancy loss, including multiple recurrent CHM (familial recurrent biparental HM syndrome). The majority of these cases are related to maternal genetic mutations in genes related to the control of imprinting, specifically NALP7 and KHDC3L. Read More

View Article and Full-Text PDF
December 2020