13,669 results match your criteria Hyaline Membrane Disease Imaging


Chondrosarcoma of the pelvis - case report.

Rom J Morphol Embryol 2018 ;59(3):927-931

Department of Obstetrics and Gynecology, University Emergency Hospital of Bucharest, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

Chondrosarcoma (CHS) is the third most common primary bone tumor after myeloma and osteosarcoma. Histologically, it is made of pure hyaline cartilage differentiation. The tumor itself may have myxoid modification and calcification. Read More

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January 2018

Osteochondral tissue repair in osteoarthritic joints: clinical challenges and opportunities in tissue engineering.

Biodes Manuf 2018 28;1(2):101-114. Epub 2018 May 28.

1Institute of Orthopaedic and Musculoskeletal Science, Division of Surgery and Interventional Science, University College London, Royal National Orthopaedic Hospital, Stanmore, HA7 4LP UK.

Osteoarthritis (OA), identified as one of the priorities for the Bone and Joint Decade, is one of the most prevalent joint diseases, which causes pain and disability of joints in the adult population. Secondary OA usually stems from repetitive overloading to the osteochondral (OC) unit, which could result in cartilage damage and changes in the subchondral bone, leading to mechanical instability of the joint and loss of joint function. Tissue engineering approaches have emerged for the repair of cartilage defects and damages to the subchondral bone in the early stages of OA and have shown potential in restoring the joint's function. Read More

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Analysis of bone osteometry, mineralization, mechanical and histomorphometrical properties of tibiotarsus in broiler chickens demonstrates a influence of dietary chickpea seeds (Cicer arietinum L.) inclusion as a primary protein source.

PLoS One 2018 11;13(12):e0208921. Epub 2018 Dec 11.

Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Lublin, Poland.

This study was focused on analyzing the effects of dietary inclusion of raw chickpea seed as a replacement of soybean meal as a primary protein source on bone structure in broiler chickens. Broiler chickens (n = 160) received in their diet either soybean meal (SBM) or raw chickpea seeds (CPS) as a primary protein source throughout the whole rearing period (n = 80 in each group). On the 42th day randomly selected chickens from each group (n = 8) were slaughtered. Read More

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December 2018

Morphological and molecular characterization of two new species of the genus Aporcelinus Andrássy, 2009 (Nematoda, Dorylaimida, Aporcelaimidae) from the USA, with new insights on the phylogeny of the genus.

J Helminthol 2018 Dec 11:1-10. Epub 2018 Dec 11.

Departamento de Biología Animal, Biología Vegetal y Ecología,Universidad de Jaén,Campus 'Las Lagunillas' s/n,Edificio B3,23071- Jaén,Spain.

Two new species of the genus Aporcelinus from the USA are described and illustrated. Aporcelinus floridensis sp. n. Read More

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December 2018

IL37 protects stem cell-based cartilage formation in an inflammatory OA-like micro-environment.

Tissue Eng Part A 2018 Dec 10. Epub 2018 Dec 10.

Radboudumc, 6034, Experimental Rheumatology, Nijmegen, Netherlands ;

Introduction Osteoarthritis (OA) is characterized by progressive loss of articular cartilage. Because cartilage has limited regenerative capacity there is need for methods to repair damaged cartilage. Human mesenchymal stem cells (MSCs) have potential to differentiate into chondrocytes and can be used for cartilage tissue engineering in vitro and in vivo. Read More

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December 2018

Chondrosarcoma: biology, genetics, and epigenetics.

Authors:
Warren A Chow

F1000Res 2018 20;7. Epub 2018 Nov 20.

Department of Medical Oncology & Therapeutics Research, City of Hope, 1500 E. Duarte Rd, Duarte, CA, 91010, USA.

Chondrosarcomas constitute a heterogeneous group of primary bone cancers characterized by hyaline cartilaginous neoplastic tissue. They are the second most common primary bone malignancy. The vast majority of chondrosarcomas are conventional chondrosarcomas, and most conventional chondrosarcomas are low- to intermediate-grade tumors (grade 1 or 2) which have indolent clinical behavior and low metastatic potential. Read More

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November 2018
2 Reads

Families and genera of diaporthalean fungi associated with canker and dieback of tree hosts.

Persoonia 2018 Dec 6;40:119-134. Epub 2018 Feb 6.

Westerdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

In this study we accept 25 families in based on phylogenetic analyses using partial ITS, LSU, and gene sequences. Four different families associated with canker and dieback of tree hosts are morphologically treated and phylogenetically compared. These include three new families (, , ), and one new genus, (). Read More

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December 2018

A Mixed Variant of Castleman Disease Detected by Somatostatin Receptor Scintigraphy with 99mTc-HYNIC-TOC and 18F-FDG PET/CT.

Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.

From the Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital; and Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, People's Republic of China.

A 50-year-old woman was found with a hypervascular abdominal mass in the right lower quadrant in contrast-enhanced CT. Somatostatin receptor scintigraphy with Tc-HYNIC-TOC showed positivity of the abdominal mass and detected additional lesion with moderate increased radioactivity in the right axilla. In F-FDG PET/CT, both of the lesions were FDG-avid. Read More

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December 2018

Biomaterials and gene therapy: a smart combination for MSC musculoskeletal engineering.

Curr Stem Cell Res Ther 2018 Dec 5. Epub 2018 Dec 5.

UMR 7365 CNRS-UL IMoPA, Université de Lorraine, Nancy. France.

Musculoskeletal pathologies, especially those affecting bones and joints, remain a challenge for regenerative medicine. The main difficulties affecting bone tissue engineering are the size of the defects, the need for blood vessels and the synthesis of appropriate matrix elements in the engineered tissue. Indeed, the cartilage is an avascular tissue and consequently has limited regenerative abilities. Read More

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December 2018

Localized pancreatic Castleman disease presenting with extrahepatic dilatation of bile ducts: A case report and review of published cases.

Int J Surg Case Rep 2018 Nov 20;54:28-33. Epub 2018 Nov 20.

Universidade Federal do Vale do São Francisco, Av. José de Sá Maniçoba, S/N - Centro, CEP: 56304-917, Petrolina, PE, Brazil. Electronic address:

Introduction: Castleman disease (CD) is a rare polyclonal lymphoproliferative disorder of unknown etiology, which usually develops in the mediastinum. It can also occur in the cervical, retroperitoneal and axillary regions. Localized pancreatic CD is quite rare [1]. Read More

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November 2018
1 Read

Shoulder Anatomy and Normal Variants.

J Belg Soc Radiol 2017 Dec 16;101(Suppl 2). Epub 2017 Dec 16.

University Hospital Brussels, BE.

The shoulder joint is functionally and structurally complex and is composed of bone, hyaline cartilage, labrum, ligaments, capsule, tendons and muscles. It links the trunk to the upper limb and plays an important biomechanical role in daily activities. Indications for imaging of the shoulder have considerably increased in the last few years. Read More

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December 2017
1 Read

Neocucurbitaria keratinophila: An emerging opportunistic fungus causing superficial mycosis in Spain.

Med Mycol 2018 Nov 29. Epub 2018 Nov 29.

Mycology Unit, Medical School and IISPV, University Rovira i Virgili, C/ Sant Llorenç 21, 43201 Reus, Spain.

Although there have been few reports of opportunistic infections (superficial and systemic) caused by coelomycetous fungi, they are becoming more frequent. Neocucurbitaria keratinophila (formerly Pyrenochaeta keratinophila), characterized by producing pycnidial conidiomata and small hyaline conidia, seems to be an emergent opportunistic pathogen in Spain. Since this fungus was first reported from human keratitis, eight strains have been isolates from clinical cases in Spain. Read More

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November 2018
1 Read

A new species of Bryconops Kner (Characiformes: Iguanodectidae) from the Rio Maicuru, lower Amazon basin, Brazil.

Zootaxa 2018 Nov 8;4514(3):372-382. Epub 2018 Nov 8.

Instituto Nacional de Pesquisas da Amazônia, Programa de Pós-Graduação em Biologia de Água Doce e Pesca Interior, Coleção de Peixes. Av. André Araújo, 2936, Caixa Postal 2223, 69060-001 Manaus, Amazonas, Brazil..

A new species of Bryconops is described from the rio Maicuru, a tributary of the left margin of the lower Amazon River, Pará, Brazil. Bryconops chernoffi new species, differs from all its congeners by the presence of an elongated dark patch of pigmentation immediately after the posterodorsal margin of the opercle, running vertically from the supracleithrum to the distal margin of the cleithrum (vs. absence of a similar blotch), and by a dark dorsal fin with a narrow hyaline band at middle portion of dorsal-fin rays (vs. Read More

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November 2018

Clinically Meaningful Improvement After Treatment of Cartilage Defects of the Knee With Osteochondral Grafts.

Am J Sports Med 2018 Nov 27:363546518808030. Epub 2018 Nov 27.

Sports Medicine Service, Hospital for Special Surgery, New York, New York, USA.

Background:: Mosaicplasty and fresh osteochondral allograft transplantation (OCA) are popular cartilage restoration techniques that involve the single-stage implantation of viable, mature hyaline cartilage-bone dowels into chondral lesions of the knee. Recently, there has been greater focus on what represents a clinically relevant change in outcomes reporting, and commonly applied metrics for measuring clinical significance include the minimal clinically important difference (MCID) and substantial clinical benefit (SCB).

Purpose:: To define the MCID and SCB after mosaicplasty or OCA for the International Knee Documentation Committee (IKDC) subjective form and Knee Outcome Survey-Activities of Daily Living (KOS-ADL) and to determine patient factors that are predictive of achieving the MCID and SCB after mosaicplasty or OCA. Read More

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November 2018
2 Reads

Hip involvement in patients with calcium pyrophosphate deposition disease: potential and limits of musculoskeletal ultrasound.

Arthritis Care Res (Hoboken) 2018 Nov 26. Epub 2018 Nov 26.

Polytechnic University of Marche, Rheumatology Unit, Department of Clinical and Molecular Sciences.

Objectives: To preliminarily explore the diagnostic potential of ultrasound (US) in detecting calcium pyrophosphate crystal (CPP) deposits at the hip joint in a cohort of patients with calcium pyrophosphate deposition disease (CPPD) which were previously evaluated by conventional radiography (CR); to assess the sensitivity and specificity as well as the agreement between US and CR in the evaluation of hip CPP crystal deposits.

Design: Fifty consecutive patients with "definite" CPPD and 40 age/sex/body mass index-matched disease controls who had undergone hip CR within the previous six months were enrolled. Bilateral hip US examination was carried out by one of the authors (A. Read More

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November 2018
1 Read
4.713 Impact Factor

Characterization of embryonic cells obtained from multifetal reduction.

Front Biosci (Elite Ed) 2019 01 1;11:79-88. Epub 2019 Jan 1.

Center of Excellence for Stem Cells and Regenerative Medicine (CESC), Zewail City of Science and Technology, Giza, Egypt,

The multifetal reduction (MFR) procedure is usually reserved for high-order multiple pregnancies, and aspirated tissues are typically discarded. In this study, cells obtained from MFR tissue (termed multifetal reduction embryonic cells (MFR-ECs)), were characterized by genotypic and phenotypic analyses and tested by injection under the kidney capsule of nude mice. MFR-ECs were highly proliferative in culture and showed a normal karyotype by microarray CGH. Read More

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January 2019
5 Reads

Severe whipworm (Trichuris spp.) infection in the hamadryas baboon (Papio hamadryas).

J Vet Med Sci 2018 Nov 21. Epub 2018 Nov 21.

College of Veterinary Medicine, Kyungpook National University.

A 3-year-old male hamadryas baboon (Papio hamadryas) at the Seoul Zoo, Korea, died without any previous symptoms. Necropsy revealed severe whipworm infection in the large intestine. The animal weighed 2. Read More

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November 2018
5 Reads

Association of VDR-FokI and VDBP-Thr420Lys polymorphisms with cervical spondylotic myelopathy: A case-control study in the population of China.

J Clin Lab Anal 2018 Nov 21:e22669. Epub 2018 Nov 21.

Department of Pain, the People's Hospital of Mengyin County, Mengyin, China.

Background: Cervical spondylotic myelopathy (CSM), a common degenerative disorder, is characterized by chronic progressive compression of the cervical spinal cord. The present case-control study aimed to explore the potential role of VDR-FokI and VDBP-Thr420Lys polymorphisms in the susceptibility to CSM in the Chinese population.

Methods: The study enrolled 318 CSM patients and 282 healthy individuals whose clinical data were retrospectively analyzed. Read More

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November 2018
9 Reads

First Report of the Yellow Nutsedge Cyst Nematode, , in Georgia, U.S.A.

J Nematol 2018 ;50(3):456-458

California Department of Food and Agriculture, Plant Pest Diagnostic Center, Sacramento, California, 95832.

Soil samples collected during a survey for plant-parasitic nematodes in Tift County GA in summer 2017 were submitted for routine diagnosis of nematodes to the Extension Nematology Lab at the Department of Plant Pathology, University of Georgia, Athens, Georgia. Cyst nematodes recovered by centrifugal flotation technique were discovered in the samples from two research sites in a field with a history of tobacco and vegetable production. Cyst nematodes from tobacco (10 cysts/100 cm 3 of soil) and vegetable (2 cysts/100 cm 3 of soil) sites had similar morphological features. Read More

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January 2018
3 Reads

An injectable continuous stratified structurally and functionally biomimetic construct for enhancing osteochondral regeneration.

Biomaterials 2018 Nov 13;192:149-158. Epub 2018 Nov 13.

Shanghai Jiao Tong University Affiliated Sixth People's Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, 200030, PR China; School of Biomedical Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, 200030, PR China. Electronic address:

Osteochondral regeneration with the formation of hyaline cartilage and subchondral bone as well as the integration between the newly formed tissues with the host tissue still remains a great challenge. In this study, a construct containing an injectable continuous stratified scaffold and multiple cell systems was designed for enhancing osteochondral regeneration. Briefly, an injectable sodium alginate(SA)/bioglass (BG) composite hydrogel containing bone marrow stem cells (BMSCs) (SA/BG + BMSCs) was used for subchondral bone regeneration and an injectable thermosensitive SA/agarose (AG) composite hydrogel with co-culture of BMSCs and articular chondrocytes (ACs) (SA/AG + ACs/BMSCs) was applied for articular cartilage regeneration. Read More

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November 2018
4 Reads

The effect of adipose-derived mesenchymal stem cells and chondrocytes with platelet-rich fibrin releasates augmentation by intra-articular injection on acute osteochondral defects in a rabbit model.

Knee 2018 Dec 9;25(6):1181-1191. Epub 2018 Nov 9.

School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan; Department of Post-Baccalaureate Veterinary Medicine, Asia University, Taichung, Taiwan. Electronic address:

Background: This study aimed to investigate the efficacy of adipose-derived mesenchymal stem cells (ADSCs), platelet-rich fibrin releasates (PRFr), and chondrocyte transplantation in rabbit acute osteochondral defects.

Methods: Thirty rabbits were randomly assigned to five groups: untreated controls; ADSCs alone; PRFr alone; PRFr + ADSCs; and PRFr + chondrocytes. The critical size osteochondral defects in right knee femoral condyles were injected intra-articularly according to the groups, as listed. Read More

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December 2018
4 Reads

The MEK-ERK1/2 signaling pathway regulates hyaline cartilage formation and the redifferentiation of dedifferentiated chondrocytes in vitro.

Am J Transl Res 2018 15;10(10):3068-3085. Epub 2018 Oct 15.

Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.

The aim of this study was to investigate the role of the mitogen-activated protein kinase kinase-extracellular signal-regulated kinases 1/2 (MEK-ERK1/2) signaling pathway in chondrocyte differentiation and cartilage tissue construction . Chondrocytes were stimulated with rat serum (RS) and fetal bovine serum (FBS), and chondrocyte phenotypes were investigated microscopically. Chondrocyte proliferation was analyzed using fluorescence activated cell sorting (FACS) and the CCK8 method. Read More

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October 2018

Human Synovial MSC Good Manufacturing Practices for Articular Cartilage Regeneration.

Tissue Eng Part C Methods 2018 Nov 9. Epub 2018 Nov 9.

Hospital Sirio-Libanes, 42522, Cell Therapy Laboratory, São Paulo, São Paulo, Brazil ;

Background: cartilage restoration is a desperately needed bridge for patients with symptomatic cartilage lesions. Chondral lesion is a pathology with high prevalence, reaching as much as 63% of general population and 36% among athletes. Despite Autologous Chondrocyte Implantation (ACI) versatility, it still fails to fully reproduce hyaline articular cartilage characteristics. Read More

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November 2018
6 Reads

Masked pemphigus among pediatric patients with Castleman's disease.

Int J Rheum Dis 2018 Nov 8. Epub 2018 Nov 8.

Department of Pathology, Taichung Veterans General Hospital, Taichung, Taiwan.

Aim: Paraneoplastic pemphigus (PNP) is a mucocutaneous autoimmune disorder accompanied with a neoplasm. Castleman's disease (CD), although rare, is the most common cause of PNP in children. It can be life-threatening when pulmonary involvement occurs. Read More

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November 2018
5 Reads

Extraskeletal Mesenchymal Chondrosarcoma.

Arch Pathol Lab Med 2018 Nov;142(11):1421-1424

From the Department of Pathology, University of Texas Health Science Center, San Antonio. Dr Arora is now with the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas. Dr Riddle is now with the Department of Pathology, Cunningham Pathology, Birmingham, Alabama.

Extraskeletal mesenchymal chondrosarcoma is a rare soft tissue sarcoma arising from soft tissues, mainly of the lower extremities, meninges, and orbits. It usually presents during the second to third decades of life, and has a slight predominance in females. Histologically, it has a typical biphasic pattern comprising small cells and islands of hyaline cartilage. Read More

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November 2018

Cartilage degradation in osteoarthritis: A process of osteochondral remodeling resembles the endochondral ossification in growth plate?

Med Hypotheses 2018 Dec 27;121:183-187. Epub 2018 Aug 27.

The Department of Spinal Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111, Dade Road, Yuexiu District, Guangzhou 510120, China; Guangzhou University of Chinese Medicine, No. 12, Jichang Road, Baiyun District, Guangzhou 510405, China. Electronic address:

Osteoarthritis (OA) is one of the most common degenerative disease which causes pain and disability of joint and brings heavy socioeconomic burden in the world. However, the pathogenesis of OA has not been fully understood. Articular cartilage degradation or loss was often regarded as the characteristic of osteoarthritis. Read More

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December 2018
7 Reads

Preservation of Knee Articular Cartilage.

Sports Med Arthrosc Rev 2018 Dec;26(4):e23-e30

Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL.

Hyaline articular cartilage is critical for the normal functioning of the knee joint. Untreated focal cartilage defects have the potential to rapidly progress to diffuse osteoarthritis. Over the last several decades, a variety of interventions aiming at preserving articular cartilage and preventing osteoarthritis have been investigated. Read More

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December 2018
5 Reads

Acute renal insufficiency and pancreatitis in a child with atypical Henoch-Schönlein purpura: efficacy of a single dose of cyclophosphamide.

J Int Med Res 2018 Nov 5:300060518800864. Epub 2018 Nov 5.

1 University Department Pro.Sa.M.I. "G. D'Alessandro", University of Palermo, Palermo, Italy.

A 9-year-old boy with petechiae on the legs and abdominal pain was unsuccessfully treated with steroids. He was admitted to our hospital for the onset of fever, ecchymosis, and arthralgia. Skin lesions suggested vasculitis, but they were not typical of Henoch-Schönlein purpura. Read More

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November 2018
5 Reads

Reporting of acute programme variables and exercise descriptors in rehabilitation strength training for tibiofemoral joint soft tissue injury: A systematic review.

Phys Ther Sport 2018 Nov 24;34:227-237. Epub 2018 Oct 24.

Faculty of Sport, Health and Applied Sciences, St Mary's University, Waldegrave Road, Twickenham, TW1 4SX, UK. Electronic address:

Objective: Strength training acute programme variables (APVs) can impact tibiofemoral joint injury outcomes. Exercise descriptors (EDs; e.g. Read More

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November 2018
3 Reads

Agili-C implant promotes the regenerative capacity of articular cartilage defects in an ex vivo model.

Knee Surg Sports Traumatol Arthrosc 2018 Nov 1. Epub 2018 Nov 1.

Department of Biomedical Sciences, Humanitas University, Via Manzoni 113, 20089, Rozzano, Milan, Italy.

Purpose: Osteochondral implants are currently adopted for the treatment of symptomatic full-thickness chondral and osteochondral defects. Agili-C™ is a cell-free aragonite-based scaffold which aims to reproduce the original structure and function of the articular joint while directing the growth and regeneration of both cartilage and its underlying subchondral bone. The goal of the present study was to investigate the ex vivo mechanisms of action (MOA) of the Agili-C™ implant in the repair of full-thickness cartilage defects. Read More

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November 2018
9 Reads

[Current Options and Importance of Imaging of the Hyaline Articular Cartilage of the Knee Prior to the Surgery - a Different Perspective of an Orthopaedic Surgeon and a Radiologist].

Acta Chir Orthop Traumatol Cech 2018 ;85(5):366-369

Klinika radiologie a nukleární medicíny Fakultní nemocnice Brno a Lékařské fakulty Masarykovy univerzity, Brno.

The authors present an overview of the commonly used techniques and new trends of the cartilage imaging, especially postoperatively, and also discuss the potential of MRI imaging of the cartilage from the perspective of an experienced orthopaedic surgeon. In conclusion, the authors propose possible explanations for the potential discrepancies between the MRI and the arthroscopic findings. Hyaline cartilage damage and subsequent reparation of this tissue is one of the topical issues of orthopaedics and traumatology. Read More

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January 2018
1 Read

Articular cartilage regeneration and tissue engineering models: a systematic review.

Arch Orthop Trauma Surg 2018 Oct 31. Epub 2018 Oct 31.

Clinic for Orthopedics and Trauma Surgery, University Hospital Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.

Introduction: Cartilage regeneration and restoration is a major topic in orthopedic research as cartilaginous degeneration and damage is associated with osteoarthritis and joint destruction. This systematic review aims to summarize current research strategies in cartilage regeneration research.

Materials And Methods: A Pubmed search for models investigating single-site cartilage defects as well as chondrogenesis was conducted and articles were evaluated for content by title and abstract. Read More

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October 2018
1 Read

Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing.

Stem Cells 2018 Oct 31. Epub 2018 Oct 31.

Department of Orthopaedic Surgery, Washington University, St. Louis, Missouri, USA.

The differentiation of human induced pluripotent stem cells (hiPSCs) to prescribed cell fates enables the engineering of patient-specific tissue types, such as hyaline cartilage, for applications in regenerative medicine, disease modeling, and drug screening. In many cases, however, these differentiation approaches are poorly controlled and generate heterogeneous cell populations. Here, we demonstrate cartilaginous matrix production in three unique hiPSC lines using a robust and reproducible differentiation protocol. Read More

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October 2018
1 Read

[Demineralized cancellous bone seeded with allogeneic chondrocytes for repairing articular osteochondral defects in rabbits].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Aug;38(9):1039-1044

Xi'an Jiaotong University Health Science Center, Institute of Endemic Diseases, Key Laboratory of Environment and Genes Related to Diseases, Xi'an 710061, China.

Objective: To evaluate the effect of demineralized cancellous bone (DCB) seeded with allogeneic chondrocytes for repairing articular osteochondral defects in rabbits.

Methods: Articular chondrocytes were isolated from a 1-month-old male New Zealand rabbit for primary culture. The passage 1 chondrocytes were seeded onto prepared rabbit DCB scaffold to construct tissue-engineered cartilage and cultured for 2 weeks. Read More

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August 2018
6 Reads

Sizable Scaffold-Free Tissue-Engineered Articular Cartilage Construct for Cartilage Defect Repair.

Artif Organs 2018 Oct 29. Epub 2018 Oct 29.

Cell Therapy Center, Ajou University Medical center, Suwon, Korea.

This study introduces an implantable scaffold-free cartilage tissue construct (SF) that is composed of chondrocytes and their self-produced extracellular matrix (ECM). Chondrocytes were grown in vitro for up to 5 weeks and subjected to various assays at different time points (1, 7, 21, and 35 days). For in vivo implantation, full-thickness defects (n = 5) were manually created on the trochlear groove of the both knees of rabbits (16-week old) and 3 week-cultured SF construct was implanted as an allograft for a month. Read More

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October 2018
1 Read

TET2-Mediated Spatiotemporal Changes of 5-Hydroxymethylcytosine During Organogenesis in the Late Mouse Fetus.

Anat Rec (Hoboken) 2018 Oct 28. Epub 2018 Oct 28.

Department of Anatomy, Guangzhou University of Chinese Medicine, No. 232, Waihuandong Road, Panyu, Guangzhou, 510006, China.

Genomic DNA demethylation is important for mammalian embryonic development and organ function. 5-Hydroxymethylcytosine (5hmC) is considered a novel epigenetic marker. Ten-eleven translocation (TET) enzymes convert 5-methylcytosine (5mC) to 5hmC. Read More

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October 2018
4 Reads

Areas of Cartilaginous and Osseous Metaplasia After Experimental Myocardial Infarction in Rats.

Anat Rec (Hoboken) 2018 Oct 28. Epub 2018 Oct 28.

Histology Department, "Carol Davila" University of Medicine and Pharmacy, 8 Eroilor Sanitari Blvd., 050474, Bucharest, Romania.

The presence of hyaline cartilage has been previously documented in heart tissue of different vertebrates, ranging from birds to superior mammals. However, there is scarce published data regarding the appearance of focal deposits of hyaline-like cartilage within the hearts of laboratory rats. Few mechanisms that could trigger the appearance of this type of cartilage in heart were hypothesized (e. Read More

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October 2018
1 Read

An injectable platelet lysate-hyaluronic acid hydrogel supports cellular activities and induces chondrogenesis of encapsulated mesenchymal stem cells.

Acta Biomater 2018 Oct 24. Epub 2018 Oct 24.

MIRA - Institute for Biomedical Technology and Technical Medicine and Department of Developmental BioEngineering, Faculty of Science and Technology, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands. Electronic address:

Developing scaffolds that can provide cells and biological cues simultaneously in the defect site is of interest in tissue engineering field. In this study, platelet lysate (PL) as an autologous and inexpensive source of growth factors was incorporated into a cell-laden injectable hyaluronic acid-tyramine (HA-TA) hydrogel. Subsequently, the effect of platelet lysate on cell attachment, viability and differentiation of human mesenchymal stem cell (hMSCs) toward chondrocytes was investigated. Read More

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October 2018
2 Reads

Transient enhancement of immune resistance functions in Litopenaeus vannamei through a low-dose octopamine injection.

Fish Shellfish Immunol 2018 Oct 24;84:532-540. Epub 2018 Oct 24.

Department of Aquaculture, National Pingtung University of Science and Technology, Pingtung, 91201, Taiwan, ROC. Electronic address:

Octopamine (OA) is known to play an important role in regulating invertebrate immune responses. In this study, we determined the effects of OA on immunity and physiological regulation in the white shrimp Litopenaeus vannamei. The total haemocyte count (THC), differential haemocyte count (DHC), phenoloxidase (PO) activity, respiratory bursts (RBs), superoxide dismutase (SOD) activity, and lysozyme, glucose, and lactate levels in plasma, and phagocytic activity and clearance efficiency in response to the pathogen, Vibrio alginolyticus, were measured when shrimp (11. Read More

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October 2018
4 Reads

Non-cystic Sclerosing Polycystic Adenosis: Diagnosis of a Hitherto Undescribed Pattern.

Head Neck Pathol 2018 Oct 25. Epub 2018 Oct 25.

Department of Pathology, National University Health System, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore.

A case of sclerosing polycystic adenosis without cysts is described. The lesion occurred as a painless slow growing superficial right parotid lump in a 47 years old woman. The tumor measured 14 × 10 mm and displayed extreme well circumscription, sclerotic stroma with scattered hyaline nodules, sprinkling of mononuclear inflammatory cells and islands of mature fat. Read More

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October 2018
3 Reads

In Situ Articular Cartilage Regeneration through Endogenous Reparative Cell Homing Using a Functional Bone Marrow-Specific Scaffolding System.

ACS Appl Mater Interfaces 2018 Nov 30;10(45):38715-38728. Epub 2018 Oct 30.

Institute of Orthopedics, Chinese PLA General Hospital , Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Lab of Musculoskeletal Trauma & War Injuries , PLA, No. 28 Fuxing Road , Beijing 100853 , P. R. China.

In situ tissue regeneration by homing endogenous reparative cells to the injury site has been extensively researched as a promising alternative strategy to facilitate tissue repair. In this study, a promising scaffolding system DCM-RAD/SKP, which integrated a decellularized cartilage matrix (DCM)-derived scaffold with a functionalized self-assembly Ac-(RADA)-CONH/Ac-(RADA)GGSKPPGTSS-CONH (RAD/SKP) peptide nanofiber hydrogel, was designed for repairing rabbit osteochondral defect. In vitro experiments showed that rabbit bone marrow stem cells migrated into and have higher affinity toward the functional scaffolding system DCM-RAD/SKP than the control scaffolds. Read More

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November 2018
4 Reads

Immunological response to bacterial infection in a pelagic tunicate: Inflammation in the salp Thalia democratica.

J Invertebr Pathol 2018 Nov 22;159:28-40. Epub 2018 Oct 22.

Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Naples, Italy.

Thaliaceans are pelagic tunicates that play a key role in trophic chains of the oceans. In the field of tunicate immunity, a notable gap is the lack of data on their inflammatory response. The common salp, Thalia democratica, possesses scant immunocytes, represented by a phagocytic line (hyaline amebocytes) and a mast cell-like line (granular cells). Read More

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November 2018
8 Reads

Regeneration of osteochondral defects using developmentally inspired cartilaginous templates.

Tissue Eng Part A 2018 Oct 25. Epub 2018 Oct 25.

Trinity College Dublin , Department of Mechanical and Manufacturing Engineering , Dublin , Dublin, Ireland ;

There is increased interest in recapitulating aspects of development when designing new tissue engineering strategies. Long bones and their epiphyses are formed through endochondral ossification, a process by which a cartilage template develops in response to genetic and environmental cues to generate a bone organ. The objective of this study was to evaluate the capacity of engineered cartilage templates to regenerate osteochondral defects created in the femoral condyle of skeletally mature rabbits. Read More

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October 2018

Clinicopathologic study of 10 cases of gastric adenocarcinoma with hepatoid or enteroblastic differentiation.

Pol J Pathol 2018 ;69(2):128-135

Gastric adenocarcinoma with hepatoid or enteroblastic differentiation (GAHED), known also as AFP-producing carcinoma, is a rare neoplasm. Ten cases with GAHED and 209 cases without GAHED were selected. Clinicopathological features of GAHED were investigated. Read More

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January 2018
3 Reads

Numerical study on electromechanics in cartilage tissue with respect to its electrical properties.

Tissue Eng Part B Rev 2018 Oct 23. Epub 2018 Oct 23.

University of Rostock, Institute of General Electrical Engineering, Albert Einstein Str. 2, Faculty of Computer Science and Electrical Engineering, Rostock, Germany.

Hyaline cartilage undergoes many substantial age-related physiochemical and biomechanical changes that reduce its ability to overcome the effects of mechanical stress and injury. In quest of therapeutic options, magnetic stimulation and electrical stimulation have been proposed for improving tissue engineering approaches for the repair of articular cartilage. The aim of the current study is to summarize in silico investigations involving induced electrical properties of cartilage tissue due to various biophysical stimuli along their respective mathematical descriptions. Read More

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October 2018

A heparan sulfate device for the regeneration of osteochondral defects.

Tissue Eng Part A 2018 Oct 23. Epub 2018 Oct 23.

Glycotherapeutics Group, Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #06-06 Immunos, Singapore 138648, Singapore, Singapore.

The regeneration of cartilage is challenging due to its low metabolic rate and avascular nature. An effective treatment for osteochondral defects remains a clinical challenge. Glycosaminoglycans such as heparan sulfate (HS) bind and enhance the activity of pro-chondrogenic growth factors and thus hold potential for targeted tissue regeneration without requiring exogenous growth factors. Read More

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October 2018

Human nasoseptal chondrocytes maintain their differentiated phenotype on PLLA scaffolds produced by thermally induced phase separation and supplemented with bioactive glass 1393.

Connect Tissue Res 2018 Oct 22. Epub 2018 Oct 22.

b Institute of Anatomy , Paracelsus Medical University , Salzburg and Nuremberg , Germany.

Damage of hyaline cartilage such as nasoseptal cartilage requires proper reconstruction, which remains challenging due to its low intrinsic repair capacity. Implantation of autologous chondrocytes in combination with a biomimetic biomaterial represents a promising strategy to support cartilage repair. Despite so far mostly tested for bone tissue engineering, bioactive glass (BG) could exert stimulatory effects on chondrogenesis. Read More

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October 2018
1 Read

Cartilage Regeneration in Preannealed Silk Elastin-Like Co-Recombinamers Injectable Hydrogel Embedded with Mature Chondrocytes in an Ex Vivo Culture Platform.

Biomacromolecules 2018 Nov 22;19(11):4333-4347. Epub 2018 Oct 22.

Technical Proteins Nanobiotechnology S.L. , Paseo Belén 9A , 47001 Valladolid , Spain.

Tissue engineering for cartilage repair requires biomaterials that show rapid gelation and adequate mechanical properties. Although the use of hydrogel is the most promising biomaterial, it often lacks in rigidity and anchorage of cells when they are surrounded by synovial fluid while they are subjected to heavy loads. We developed and produced the Silk Elastin-Like co-Recombinamer (SELR), which contains both the physical interaction from elastin motifs and from silk motifs. Read More

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November 2018
4 Reads

Hyaline Cell-Rich Apocrine Mixed Tumor with Cytologic Atypia.

Authors:
Chika Ohata

Dermatopathology (Basel) 2018 Jul-Sep;5(3):108-112. Epub 2018 Sep 13.

Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.

Hyaline cell-rich apocrine mixed tumor is relatively rare, and it often possesses atypical cells. Despite the presence of atypical cells, other histopathological features such as well circumscription, smooth border, predominance of bland cells, and no mitotic figures lead to classify these tumors as benign. In addition, no recurrence or metastasis has been reported even when cytologic atypia is identified. Read More

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September 2018

Comparison of IgG4-Related Lymphadenopathy and Multicentric Castleman's Disease: a Retrospective Study.

Clin Lab 2018 Oct;64(10):1671-1678

Background: It can be difficult to distinguish between IgG4-related lymphadenopathy and multicentric Castleman's disease (MCD) because these conditions cannot be differentially diagnosed using immunohistochemical staining alone. In this study, we analyzed the clinical features of IgG4-related lymphadenopathy and MCD patients.

Methods: We retrospectively analyzed 27 patients with MCD, including 20 with plasma cell-type (PC-type) and 7 with hyaline vascular (HV) features (mixed-type). Read More

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October 2018
2 Reads