305 results match your criteria Hyaline Membrane Disease Imaging


Cutaneous Findings of Sporadic, Adult-Onset Neuronal Intranuclear Inclusion Disease.

Am J Dermatopathol 2022 Jan;44(1):1-6

Professor of Pathology, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Abstract: Neuronal intranuclear inclusion disease is a rare, progressive neurodegenerative disease whose hallmark histopathologic finding is the presence of ubiquitin-positive hyaline intranuclear inclusions in neuronal and non-neuronal cells. We present a case of neuronal intranuclear inclusion disease in a 61-year-old Asian man with a history of repeated episodes of altered mental status, long-standing bladder dysfunction, and cerebrovascular accidents. The patient had characteristic magnetic imaging findings of high signal along the cortico-medullary junction on diffusion-weighted sequences and symmetric T2 hyperintensity in the paravermal area of the cerebellum. Read More

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January 2022

COVID-19 ARDS: a review of imaging features and overview of mechanical ventilation and its complications.

Emerg Radiol 2022 Feb 26;29(1):23-34. Epub 2021 Oct 26.

Department of Radiology & Biomedical Imaging, Yale School of Medicine; Thoracic Imaging section, Yale-New Haven Hospital, Yale New Haven Health, New Haven, CT, USA.

The first cluster of cases of COVID-19 pneumonia was reported on December 31, 2019. Since then, this disease has spread rapidly across the world, and as of September 17, 2021, there are 226,844,344 cases of COVID-19 worldwide with 4,666,334 deaths related to COVID-19. While most COVID-19 cases are mild, some cases are severe with patients developing acute respiratory distress syndrome (ARDS). Read More

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February 2022

Artificial osteochondral interface of bioactive fibrous membranes mediating calcified cartilage reconstruction.

J Mater Chem B 2021 09 29;9(37):7782-7792. Epub 2021 Sep 29.

Bio-nanomaterials and Regenerative Medicine Research Division, Zhejiang-California International Nanosystem Institute, Zhejiang University, Hangzhou 310058, China.

Calcified cartilage is a mineralized osteochondral interface region between the hyaline cartilage and subchondral bone. There are few reported artificial biomaterials that could offer bioactivities for substantial reconstruction of calcified cartilage. Herein we developed new poly(L-lactide--caprolactone) (PLCL)-based trilayered fibrous membranes as a functional interface for calcified cartilage reconstruction and superficial cartilage restoration. Read More

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September 2021

Minimally invasive therapy for the resolution of a subcapsular hepatic hematoma in a newborn.

Andes Pediatr 2021 Feb 22;92(1):99-103. Epub 2021 Feb 22.

Clínica Alemana Santiago, Santiago, Chile.

Objective: To describe an innovative alternative to exploratory laparotomy in a newborn with a sub capsular hepatic hematoma secondary to umbilical vein catheterization.

Clinical Case: A preterm baby with a history of hyaline membrane disease, pulmonary hypertension, and large patent ductus arteriosus, requiring mechanical ventilation and the use of vasoactive drugs. Umbilical catheters were inserted and through an abdomen X-ray, we observed their proper position. Read More

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February 2021

Coalescing expansile skeletal disease: Delineation of an extraordinary osteopathy involving the IFITM5 mutation of osteogenesis imperfecta type V.

Bone 2021 04 24;145:115835. Epub 2020 Dec 24.

Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110, USA; Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, MO 63110, USA. Electronic address:

In 2003, we briefly reported the remarkable osteopathy of a 12-year-old boy who at age two months began fracturing his limbs with subsequent hyperplastic callus formation and expansion and fusion of appendicular bones. By age ten years he had coalesced his lumbosacral spine, pelvis, femurs, and leg and foot bones as a single structure. Computed tomography of expanded bone revealed a thin cortical shell, diminished irregular trabeculae, and cystic areas. Read More

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Comparison of Long Term Follow-up Chest CT Imaging in Adult and Pediatric Patients with Humidifier Disinfectant-related Lung Injury.

J Korean Med Sci 2020 Nov 23;35(45):e377. Epub 2020 Nov 23.

Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.

Background: To compare the chest computed tomography (CT) images of children and adults in families with clusters of humidifier disinfectant-related lung injury (HDLI) after cessation of exposure to humidifier disinfectant (HD).

Methods: We reviewed medical records of 19 families with 43 patients (21 adults, 22 children) among families, which had at least one adult and one child with HDLI. Each family was exposed to the same HD exposure environment. Read More

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November 2020

Radiologic Features of Type II and Type XI Collagenopathies.

Radiographics 2021 Jan-Feb;41(1):192-209. Epub 2020 Nov 13.

From the Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52242 (A.H.); Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet and Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden (G.G.); and Center for Intractable Diseases, Saitama Medical University Hospital, Saitama, Japan (G.N.).

Type II collagen is a major component of the cartilage matrix. Pathogenic variants (ie, disease-causing aberrations) in the type II collagen gene lead to an abnormal structure of type II collagen, causing a large group of skeletal dysplasias termed Because type II collagen is also located in the vitreous body of the eyes and inner ears, type II collagenopathies are commonly associated with vitreoretinal degeneration and hearing impairment. Type II collagenopathies can be radiologically divided into two major groups: the spondyloepiphyseal dysplasia congenita (SEDC) group and the Kniest-Stickler group. Read More

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November 2021

Novel homozygous missense mutation in ABCA3 protein leading to severe respiratory distress in term infant.

BMJ Case Rep 2020 Oct 10;13(10). Epub 2020 Oct 10.

Neonatology, Madhukar Rainbow Children Hospital, Delhi, India.

The term baby presented with respiratory distress with X-ray pictures consistent as hyaline membrane disease (HMD). Baby was ventilated and treated with surfactant. Because of the persistence of high ventilation needs with X-ray pictures consistent with HMD with a transient response to surfactant every time, the possibility of an inherited disorder of surfactant metabolism was kept. Read More

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October 2020

Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies.

Mod Pathol 2020 06 14;33(6):1007-1014. Epub 2020 Apr 14.

Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Data on pathologic changes of the 2019 novel coronavirus disease (COVID-19) are scarce. To gain knowledge about the pathology that may contribute to disease progression and fatality, we performed postmortem needle core biopsies of lung, liver, and heart in four patients who died of COVID-19 pneumonia. The patients' ages ranged from 59 to 81, including three males and one female. Read More

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Plasminogen improves lung lesions and hypoxemia in patients with COVID-19.

QJM 2020 Aug;113(8):539-545

Department of Basic Research, Talengen Institute of Life Sciences, Shenzhen, P.R. China.

Background: Lungs from patients with coronavirus disease 2019 (COVID-19) have shown typical signs of acute respiratory distress syndrome (ARDS), formation of hyaline membrane mainly composed of fibrin and 'ground-glass' opacity. Previously, we showed plasminogen itself is a key regulator in fibrin degradation, wound healing and infection.

Aim: We aimed to investigate whether plasminogen can improve lung lesions and hypoxemia of COVID-19. Read More

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Tension pneumocephalus, an uncommon complication of oxygen therapy in preterm newborns. Presentation of a case and literature review.

Neurocirugia (Astur : Engl Ed) 2021 Mar-Apr;32(2):84-88. Epub 2019 Nov 26.

Servicio de Neurocirugía, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, España.

Tension pneumocephalus is an extremely rare complication of positive-pressure ventilation in neonates, the diagnosis of which requires a high degree of clinical suspicion. We present the case of a preterm newborn, who received high-flow nasal cannula oxygen therapy because of hyaline membrane disease, due to his prematurity, and developed clinical signs of intracranial hypertension. Transfontanellar ultrasound and cranial CT scan revealed significant tension pneumocephalus, which was evacuated with direct needle puncture through the anterior fontanelle. Read More

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Tenosynovial Giant Cell Tumor, Localized Type With Extensive Chondroid Metaplasia: A Case Report With Immunohistochemical and Molecular Genetic Analysis.

Int J Surg Pathol 2020 Jun 26;28(4):447-453. Epub 2019 Nov 26.

Shimane University, Izumo, Shimane, Japan.

Tenosynovial giant cell tumor (TSGCT) of localized type is a common disease occurring mostly in the hands. Diagnosis of this tumor is relatively easy to render with hematoxylin-eosin-stained sections as compared with that of TSGCT of diffuse type. However, very rare cases with chondroid metaplasia that have recently been reported mainly in diffuse type can make pathological differentiation from soft tissue cartilaginous tumors extremely difficult. Read More

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Pulmonary Hyalinising Granuloma: A report of two cases.

Sultan Qaboos Univ Med J 2019 May 8;19(2):e157-e160. Epub 2019 Sep 8.

Department of Radiology, Royal Hospital, Muscat, Oman.

Pulmonary hyalinising granuloma (PHG) is a rare fibrosclerosing inflammatory lung condition of unknown aetiology. It is characterised by solitary or multiple pulmonary nodules that are usually found incidentally while imaging the chest for other reasons. We report two cases of histologically proven PHG diagnosed at the Royal Hospital, Muscat, Oman. Read More

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Spontaneous resolution of pneumopericardium in a preterm infant.

BMJ Case Rep 2019 May 8;12(5). Epub 2019 May 8.

Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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Osteosarcoma in an Adolescent with Kniest Dysplasia: A Case Report.

JBJS Case Connect 2018 Oct-Dec;8(4):e78

Musculoskeletal Research Center, Department of Orthopaedic Surgery, Children's Hospital Colorado, Aurora, Colorado.

Case: A 19-year-old adolescent with Kniest dysplasia was incidentally found to have osteosarcoma of the proximal aspect of the humerus after having a chest radiograph for evaluation of an upper respiratory infection. He underwent chemotherapy and resection of the tumor, and there was no evidence of metastasis at the 16-month follow-up.

Conclusion: Patients with osteochondrodysplasias often have multiple orthopaedic symptoms. Read More

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November 2019

Hardness and Painful Lesion of the Breast.

Acta Dermatovenerol Croat 2017 Dec;25(4):305-306

Alejandro Vilas Sueiro, MD, Department of Dermatology, Naval Hospital, University Hospital Complex of Ferrol, Avenida Residencia SN, 15405 Ferrol (A Coruña), Spain;

Dear Editor, Lupus panniculitis or lupus profundus is a rare inflammatory complication found in patients with systemic lupus erythematosus (SLE), or discoid lupus erythematosus (DLE) (1). When the breast is involved, the term lupus mastitis (LM) is used. This disease involving the breast is rare, and the lesions may precede, coincide with, or occur later than the onset of other lupus lesions. Read More

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December 2017

Pulmonary atelectasis in newborns with clinically treatable diseases who are on mechanical ventilation: clinical and radiological aspects.

Radiol Bras 2018 Jan-Feb;51(1):20-25

Assistant Professor in the Radiology Department of the Faculdade de Ciências Médicas da Universidade Estadual de Campinas (FCM-Unicamp), Campinas, SP, Brazil.

Objective: To analyze the radiological aspects of pulmonary atelectasis in newborns on mechanical ventilation and treated in an intensive care unit, associating the characteristics of atelectasis with the positioning of the head and endotracheal tube seen on the chest X-ray, as well as with the clinical variables.

Materials And Methods: This was a retrospective cross-sectional study of 60 newborns treated between 1985 and 2015. Data were collected from medical records and radiology reports. Read More

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Lung Metabolism and Inflammation during Mechanical Ventilation; An Imaging Approach.

Sci Rep 2018 02 23;8(1):3525. Epub 2018 Feb 23.

Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

Acute respiratory distress syndrome (ARDS) is a major cause of mortality in critically ill patients. Patients are currently managed by protective ventilation and alveolar recruitment using positive-end expiratory pressure (PEEP). However, the PEEP's effect on both pulmonary metabolism and regional inflammation is poorly understood. Read More

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February 2018

A pre-term infant of 32 weeks gestation with congenital tuberculosis treated successfully with antituberculosis chemotherapy.

Paediatr Int Child Health 2018 08 14;38(3):220-222. Epub 2017 Aug 14.

a Department of Neonatology , The First Affiliated Hospital of Shantou University Medical College , Shantou , China.

An infant of 32 weeks gestation was separated from her mother at birth for treatment of hyaline membrane disease and, on recovery, was cared for by adoptive parents. At 25 days, she was treated for pneumonia with immunoglobulins and multiple antibiotics and appeared to respond. Her symptoms recurred at 8 weeks and tuberculosis was confirmed by detection in an acid-fast bacilli smear of gastric aspirate. Read More

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An Unusual Presentation of Acute Fibrinous and Organizing Pneumonia.

Am J Case Rep 2017 May 15;18:532-536. Epub 2017 May 15.

Department of Internal Medicine, Bronx Lebanon Hospital Center, Bronx, NY, USA.

BACKGROUND Acute fibrinous and organizing pneumonia (AFOP) is a newly evolving rare non-infectious lung pathology, characterized by intra-alveolar fibrin balls on histology. It is often difficult to diagnose and is usually mistaken for other lung pathologies. We present an interesting case of AFOP with unusual radiologic findings and disease course. Read More

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Acute fibrinous and organizing pneumonia: A case report and literature review.

Exp Ther Med 2016 Dec 3;12(6):3958-3962. Epub 2016 Nov 3.

Department of Pulmonary and Critical Care Medicine, Nanjing General Hospital of Nanjing Military Command, People's Liberation Army, Nanjing, Jiangsu 210002, P.R. China.

Acute fibrinous and organizing pneumonia (AFOP) is a rare lung disease with distinct histological characteristics that include the diffuse presence of intra-alveolar fibrin, and the absence of eosinophils and hyaline membrane. In the present study, a case of AFOP that was diagnosed by lung biopsy is described. The patient presented with high fever and a cough with expectoration. Read More

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December 2016

Imaging manifestations and pathological analysis of severe pneumonia caused by human infected avian influenza (H7N9).

Radiol Infect Dis 2015 Mar 2;1(2):64-69. Epub 2015 Mar 2.

Third People's Hospital of Shenzhen, 518112 Guangdong, China.

Objective: To investigate the imaging and pathological findings of severe pneumonia caused by human infected avian influenza (H7N9), and therefore to further understand and improve diagnostic accuracy of severe pneumonia caused by human infected avian influenza (H7N9).

Methods: The relevant clinical and imaging data of 19 cases, including 10 males and 9 females, with pneumonia caused by human infected avian influenza (H7N9) was retrospectively analyzed. One of the cases had received percutaneous lung biopsy, with the clinical, imaging and pathological changes possible to be analyzed. Read More

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Alveolar epithelial cells undergo epithelial-mesenchymal transition in acute interstitial pneumonia: a case report.

BMC Pulm Med 2014 Apr 23;14:67. Epub 2014 Apr 23.

Department of Pulmonary medicine, Binzhou Medical University Hospital, Binzhou, P,R, China.

Background: Acute interstitial pneumonia is a rare interstitial lung disease that rapidly progresses to respiratory failure or death. Several studies showed that myofibroblast plays an important role in the evolution of diffuse alveolar damage, which is the typical feature of acute interstitial pneumonia. However, no evidence exists whether alveolar epithelial cells are an additional source of myofibroblasts via epithelial-mesenchymal transition in acute interstitial pneumonia. Read More

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GM1-gangliosidosis in American black bears: clinical, pathological, biochemical and molecular genetic characterization.

Mol Genet Metab 2014 Apr 13;111(4):513-21. Epub 2014 Feb 13.

Section of Pathology, Department of Biomedical Science, Tufts University Cummings School of Veterinary Medicine, Grafton, MA, USA; Department of Pathology, Tufts University School of Medicine, Boston, MA, USA; Tufts Medical Center, Boston, MA, USA.

G(M1)-gangliosidosis is a rare progressive neurodegenerative disorder due to an autosomal recessively inherited deficiency of lysosomal β-galactosidase. We have identified seven American black bears (Ursus americanus) found in the Northeast United States suffering from G(M1)-gangliosidosis. This report describes the clinical features, brain MRI, and morphologic, biochemical and molecular genetic findings in the affected bears. Read More

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[The clinicopathological features of acute fibrinous and organizing pneumonia].

Zhonghua Jie He He Hu Xi Za Zhi 2013 Jun;36(6):425-30

Department of Respiratory Medicine, Department of Pathology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China (Email:

Objective: To improve understanding of the clinical, radiological and pathological characteristics of acute fibrinous and organizing pneumonia (AFOP).

Methods: The clinical data of 5 AFOP patients were retrospectively analyzed. AFOP was diagnosed via percutaneous lung biopsy guided by chest computerized tomography (CT) in the Affiliated Drum Tower Hospital of Nanjing University Medical School during March 2011 to June 2012. Read More

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Role of transabdominal ultrasound of lung bases and follow-up in premature neonates with respiratory distress soon after birth.

Indian J Radiol Imaging 2012 Oct;22(4):279-83

Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Chest radiography has been the traditional method of diagnostic evaluation of patients of hyaline membrane disease (HMD). Lung sonography (USG) has been lately explored as an alternative modality.

Aims: To explore the application of transabdominal USG of lung bases (TASL) in the evaluation of HMD in premature neonates with respiratory distress soon after birth. Read More

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October 2012

Study of intraventricular hemorrhage in VLBW neonates admitted in Al-Zahra Hospital, Tabriz, Iran.

Niger J Med 2012 Jan-Mar;21(1):92-7

Pediatric Health Research Center, Dept. of Pediatrics, Al-Zahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction And Aim: Intra-ventricular hemorrhage (IVH) is an important predictor of adverse neurodevelopmental outcome. IVH risk factor identification may conduct improvement of quality of care in neonatal intensive care units. The aim of the current study was to determine possible risk factors associated with IVH in VLBW neonates admitted in our hospital. Read More

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February 2013

[Clinical features on chromophobe renal cell carcinoma].

Zhonghua Wai Ke Za Zhi 2011 Apr;49(4):320-3

Department of Urology, Tongji Medical College of Hua Zhong University of Science and Technology, Wuhan 430030, China.

Objectives: To explore the clinical, pathological features and prognosis of patients with chromophobe renal cell carcinoma.

Methods: From January 1998 to January 2008, clinical data of 29 patients with chromophobe renal cell carcinoma including clinical manifestations, imaging examinations, treatment models, pTNM stages and follow-up results, were summarized to investigate its features and prognosis.

Results: All cases had no obvious clinical and preoperative imaging presentation. Read More

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Clinical comparisons of the anatomical reconstruction and modified biceps rerouting technique for chronic posterolateral instability combined with posterior cruciate ligament reconstruction.

J Bone Joint Surg Am 2011 May;93(9):809-18

Department of Orthopaedic Surgery, Arthroscopy and Joint Research Institute, Yonsei University Health System, CPO Box 8044, 134, Shinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea.

Background: The purpose of this study was to describe a one-stage operation for posterior cruciate ligament reconstruction with use of an Achilles tendon-bone allograft and a posterolateral corner reconstruction with use of two different methods, with a comparison of clinical outcomes in the two groups.

Methods: Our study included forty-six patients who had undergone posterior cruciate ligament reconstruction with use of an Achilles tendon-bone allograft and posterolateral corner reconstruction with either anatomical reconstruction of the lateral collateral ligament and popliteus tendon with use of a tibialis posterior tendon allograft (twenty-one patients; Group A) or the modified biceps rerouting tenodesis (twenty-five patients; Group B) in an alternating fashion. Patients were assessed for knee instability with use of the dial test at 30° and 90°, together with varus and posterior stress radiography. Read More

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Direct imaging of pH1N1 2009 influenza virus replication in alveolar pneumocytes in fatal cases by transmission electron microscopy.

J Electron Microsc (Tokyo) 2011 21;60(1):89-93. Epub 2011 Jan 21.

National Institute of Virology, 20A Dr Ambedkar Road, Pune 411001, India.

Human influenza virus pandemics constitute a major global public health issue. Although studies on autopsy specimens from the recent pandemic by the 2009 influenza A (H1N1) virus have revealed a broad spectrum of pathologic findings, direct electron microscopic studies of the lung tissue from influenza fatalities are few. In this study, we examined five well-preserved pulmonary necropsy specimens from fatal cases of laboratory-confirmed pH1N1 from India. Read More

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