- Karim Harhouri,
- Diane Frankel,
- Catherine Bartoli,
- Patrice Roll,
- Annachiara De Sandre-Giovannoli,
- Nicolas Lévy
Nucleus 2018 Apr 5:1-27. Epub 2018 Apr 5.
a Aix Marseille Univ, INSERM , MMG - U1251 , Marseille , France.
Hutchinson-Gilford progeria syndrome (HGPS) is a sporadic, autosomal dominant disorder characterized by premature and accelerated aging symptoms leading to death at the mean age of 14.6 years usually due to cardiovascular complications. HGPS is caused by a de novo point mutation in the LMNA gene encoding the intermediate filament proteins lamins A and C which are structural components of the nuclear lamina. Read More