1,356 results match your criteria Hurthle Cell Carcinoma
Pathol Oncol Res 2018 Dec 11. Epub 2018 Dec 11.
Department of Pathology, the First People's Hospital of Jingmen, Jingmen, 448000, Hubei Province, China.
To observe the expression of P53, CyclinD1, Ki-67, Galectin-3, COX-2, Bcl-2 and approach their contribution on assessing the invasive potential for Hurthle cell tumors. Seventy-three cases of Hurthle cell tumor were collected for immunohistochemistry staining. The patients were followed up with 8 months to 5 years. Read More
Case Rep Ophthalmol Med 2018 30;2018:1656131. Epub 2018 Sep 30.
Eye Institute, West Virginia University, Morgantown, WV, USA.
Acute posterior multifocal placoid pigment epitheliopathy (APMPEE) is a chorioretinal inflammatory disease of unknown origin. Patients usually present with a rapid loss of central/paracentral vision over the course of a week in both eyes. The fundus exhibits rapid appearance of multiple deep subretinal yellow-white, flat lesions at the RPE/choriocapillaris level. Read More
Int J Surg Pathol 2018 Oct 29:1066896918809490. Epub 2018 Oct 29.
1 Department of Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
Follicular neoplasms of the thyroid gland are most often characterized by follicular-patterned thyrocytes with a neutrally stained cytoplasm, while a minority of cases present with oncocytic differentiation (Hürthle cell tumors). Exceedingly rare variants with a clear cell phenotype have also been reported, both as clear cell follicular thyroid adenomas (ccFTAs) and clear cell follicular carcinomas (ccFTCs). We present a patient with a 30-mm lesion in the thyroid isthmus in which the preoperative cytology proposed a follicular tumor. Read More
Appl Immunohistochem Mol Morphol 2018 Oct 24. Epub 2018 Oct 24.
Division of Anatomic Pathology and Histology, Catholic University of Sacred Heart, Foundation "A. Gemelli" University Hospital.
It is a diagnostic challenge to differentiate benign and malignant thyroid neoplasms made up of Hürthle (or oncocytic) cells on cytologic material. They are large, polygonal cells with marked eosinophilic, granular cytoplasm reflective of overly abundant mitochondria. These cells commonly occur in nodular goiters and dominant adenomatous or hyperplastic nodules though they may also be the predominant component of neoplastic lesions. Read More
Diagn Cytopathol 2018 Nov 23;46(11):901-907. Epub 2018 Oct 23.
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Background: Molecular tests are increasingly used to triage cytologically indeterminate thyroid nodules for surgery and/or follow-up. We retrospectively compared the performance of the Afirma Gene Expression Classifier (AGEC) with that of the more recently developed RosettaGX Reveal™ miRNA Classifier (Reveal) in a cohort of Bethesda III-V thyroid FNAs with surgical follow-up.
Design: Eighty-one samples (54 Bethesda III, 26 Bethesda IV, 1 Bethesda V) with available AGEC (74 AGEC-SUSP and 7 AGEC-BENIGN) and surgical pathology results were studied from three academic centers. Read More
Nucl Med Mol Imaging 2018 Oct 27;52(5):389-393. Epub 2018 Aug 27.
1Department of Nuclear Medicine, All India Institute of Medical Sciences, E-81, Ansari Nagar (East), AIIMS Campus, New Delhi, 110029 India.
Thyroid carcinoma is the most common neoplasm of endocrine malignancies. Differentiated thyroid carcinoma (DTC) constitutes 90% of the thyroid carcinomas, rest being medullary thyroid carcinoma (MTC), and anaplastic thyroid carcinoma (ATC). Distant metastases occur in up to 10% of patients with DTC. Read More
J Surg Oncol 2018 Nov 12;118(6):1042-1049. Epub 2018 Oct 12.
Department of Surgery, New York Presbyterian Hospital-Weill Cornell Medical College, New York, New York.
Background And Objectives: Hürthle cell carcinoma (HCC) is an unusual and relatively rare type of differentiated thyroid cancer. Currently, cytologic analysis of fine-needle aspiration biopsy is limited in distinguishing benign Hürthle cell neoplasms from malignant ones. The aim of this study was to determine whether differences in the expression of specific genes could differentiate HCC from benign Hürthle cell nodules by evaluating differential gene expression in Hürthle cell disease. Read More
Ann Surg Oncol 2018 Dec 9;25(13):3913-3918. Epub 2018 Oct 9.
Department of Surgery, University of California, Davis Medical Center, Sacramento, CA, USA.
Background: The optimal management of thyroid nodules that undergo fine-needle aspiration (FNA) with findings of atypia of undetermined significance (AUS) is unclear. Categorizing nodules by AUS subtype and ultrasound characteristics may improve risk stratification. Therefore, the purpose of this study is to evaluate the association between AUS subtype and ultrasound features on risk of malignancy (ROM). Read More
Ann Saudi Med 2018 Sep-Oct;38(5):336-343
Dr. Khalid S. Aljabri, Department of Endocrinology,, King Fahd Armed Forces Hospital,, PO Box 6572, Jeddah 24361,, Saudi Arabia, T: +966-555-544919, khalidsaljabri@ yahoo.com, ORCID: http://orcid. org/0000-0001-5831-5935.
Background: Thyroid carcinoma (TC) is the ninth most common site of all cancers in women in the world and the second most common malignancy in Saudi Arabia. This reports updates data on the epidemiology of the disease in Saudi Arabia.
Objective: Describe and interpret changes in the frequency of TC to compare with other populations and determine proportions of certain histological types of TC. Read More
S Afr J Surg 2018 Sep;56(3):20-23
Department of Surgery, Chris Hani Baragwanath Academic Hospital, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand.
Background: Report of Hurthle cells following fine needle aspiration cytology from a thyroid nodule raises possibility of Hurthle cell carcinoma (HCC), which is a distinct entity and accounts for 3-10% of thyroid malignancies.
Aim: To determine if there are demographic and histopathological features which may be used to differentiate HCC from Hurthle cell adenoma (HCA).
Method: Histopathology records of patients who had thyroidectomy from January 2001 to October 2015 were reviewed. Read More
Endocr Pathol 2018 Dec;29(4):357-364
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Although differentiated thyroid carcinomas typically pursue an indolent clinical course, it is important to identify the subset of tumors that are most likely to behave aggressively so that patients with these tumors are counseled and treated appropriately. Extent of disease is fundamental to the prognostication for differentiated thyroid carcinoma; however, there are additional histologic features of the tumor separate from extent of disease that have been shown to affect clinical course. This review will start with a discussion of aggressive variants of papillary thyroid carcinoma, move to the prognostic significance of vascular invasion in follicular thyroid carcinoma, and finish with a discussion of Hürthle cell carcinoma, with an emphasis on why it is not considered a subtype of follicular thyroid carcinoma in the 2017 WHO Classification of Tumors of Endocrine Organs. Read More
Thyroid 2018 Oct 16. Epub 2018 Oct 16.
2 Department of Surgery, Division of Endocrine Surgery, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.
Background: Since its introduction nine years ago, gasless transaxillary thyroidectomy with robotic assistance (RT) has achieved a relatively limited application in North America. This study aimed to assess the outcomes of RT in a recent large, diverse North American population.
Methods: Consenting patients were selected for the RT approach from November 2010 to July 2015 based on patient preference, and their perioperative data were retrospectively reviewed. Read More
Curr Oncol Rep 2018 Sep 11;20(10):82. Epub 2018 Sep 11.
Sylvester Comprehensive Cancer Center, University of Miami - Miller School of Medicine, Miami, FL, USA.
Most common thyroid cancers are differentiated thyroid cancers (DTCs) and have papillary, follicular, or Hürthle cell morphology. Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the thyroid gland. The incidence of DTC increases with age. Read More
Histol Histopathol 2018 Sep 7:18036. Epub 2018 Sep 7.
Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea.
Purpose: We evaluated the expression of glutaminolysis-related proteins in Hurthle cell neoplasms (HCN) and follicular neoplasms (FN) of the thyroid, and investigated its clinical implication.
Methods: Tissue microarrays were constructed from 264 FNs (112 follicular carcinomas [FCs] and 152 follicular adenomas [FAs]) and 108 HCNs (27 Hurthle cell carcinomas [HCCs] and 81 Hurthle cell adenomas [HCAs]. The immunohistochemical staining result of 3 glutaminolysis-related proteins (Glutaminase 1 [GLS1], glutaminate dehydrogenase [GDH] and alanine- serine, cysteine-preferring transporter 2 [ASCT2]) was analyzed. Read More
Gland Surg 2018 Aug;7(Suppl 1):S77-S79
Division of Head and Neck Endocrine Surgery, Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
The safety and efficacy of the transoral endoscopic thyroidectomy vestibular approach (TOETVA) continues to be verified with the growing literature in regards to the procedure. While early cases were thyroid lobectomies performed for benign disease, the indications for TOETVA have now expanded to include total thyroidectomy for select small well-differentiated thyroid cancers (DTCs). Oncologic efficacy of this procedure remains unproven at this time, as the procedure was described only recently. Read More
Cancer Discov 2018 Oct 24;8(10):1207. Epub 2018 Aug 24.
Hürthle cell carcinomas (HCC) harbor recurrent somatic DNA mutations and mtDNA mutations. Read More
Cancer Cell 2018 Aug;34(2):256-270.e5
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:
The molecular foundations of Hürthle cell carcinoma (HCC) are poorly understood. Here we describe a comprehensive genomic characterization of 56 primary HCC tumors that span the spectrum of tumor behavior. We elucidate the mutational profile and driver mutations and show that these tumors exhibit a wide range of recurrent mutations. Read More
Cancer Cell 2018 Aug;34(2):242-255.e5
Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Thyroid Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Internal Medicine, Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:
Hürthle cell carcinoma of the thyroid (HCC) is a form of thyroid cancer recalcitrant to radioiodine therapy that exhibits an accumulation of mitochondria. We performed whole-exome sequencing on a cohort of primary, recurrent, and metastatic tumors, and identified recurrent mutations in DAXX, TP53, NRAS, NF1, CDKN1A, ARHGAP35, and the TERT promoter. Parallel analysis of mtDNA revealed recurrent homoplasmic mutations in subunits of complex I of the electron transport chain. Read More
Endocr Pract 2018 08 14;24(8):740-745. Epub 2018 Aug 14.
Objective: The accurate diagnosis of thyroid follicular/Hürthle cell tumors is challenging and a matter of controversy. We present a series of patients in whom a misclassification of follicular/Hürthle cell thyroid lesions as benign has led to devastating clinical outcomes.
Methods: The Thyroid Cancer Registry of Rabin Medical Center was screened for patients with metastatic differentiated thyroid carcinoma (DTC) who had been initially diagnosed with benign follicular lesion between 1974 and 2015 and treated with hemithyroidectomy. Read More
Thyroid 2018 Sep;28(9):1174-1179
8 Service de Médecine Nucléaire et de Cancérologie Endocrinienne, Institut Gustave Roussy , Villejuif et Université Paris Saclay, France .
Background: Dysregulation of the phosphatidylinositol 3-kinase (PI3K) pathway is frequent in advanced follicular (FTC) and poorly differentiated thyroid (PDTC) carcinomas and has been implicated in oncogenesis and tumor progression. This study investigated the efficacy and safety of buparlisib, a pan-PI3K inhibitor in radioiodine refractory FTC and PDTC.
Methods: The primary endpoint of this open-label, multicenter, phase 2 pilot study was progression-free survival (PFS) at 6 months. Read More
Case Rep Endocrinol 2018 16;2018:9329035. Epub 2018 Jul 16.
New York Head & Neck Institute, Lenox Hill Hospital, New York, NY, USA.
Hürthle cell predominant thyroid nodules often confound the diagnostic utility of fine needle aspiration biopsy (FNAB) with cytology often interpreted as a Hürthle cell lesion with an indeterminate risk of malignancy, Bethesda category (BC) III or IV. Molecular diagnostics for Hürthle cell predominant nodules has also been disappointing in further defining the risk of malignancy. We present a case of a slowly enlarging nodule within a goiter initially reported as benign on FNAB, BC II but on subsequent FNAB suspicious for a Hürthle cell neoplasm, BC IV. Read More
J Cytol 2018 Jul-Sep;35(3):131-138
Department of Pathology, Faculty of Medicine, Kuwait University, and Cytology Unit, Mubarak Al-Kabeer Hospital, Kuwait.
Synthesis and storage of thyroglobulin as well as synthesis of thyroid hormones and their release into the circulation are important functions of thyroid, which were studied in fine needle aspiration (FNA) smears from thyroid lesions. Evidence of thyroglobulin synthesis was demonstrated in neoplastic and nonneoplastic follicular cells, especially in Hürthle cells, in the form of colloid inclusions. Whereas the pinocytic vesicles containing colloid at the luminal end of in nonneoplastic and neoplastic follicular cells indicated engulfment of colloid for synthesis of thyroid hormones (T and T), the marginal vacuoles (MVs) (fire-flare appearance) at the basal aspects of follicular cells suggested their release on way to the interfollicular capillaries. Read More
Clin Nucl Med 2018 Oct;43(10):e352-e354
From the Departments of Nuclear Medicine.
Differentiated thyroid cancer (DTC) with thyroglobulin elevation and negative I scintigraphy (TENIS) syndrome is a diagnostic and therapeutic dilemma. Treatment of differentiated thyroid cancer has an excellent outcome, but treatment options in TENIS are limited with the exception of surgically amenable disease. We present a case of TENIS syndrome with incidental detection of tumor thrombus in right pulmonary vein extending to the left atrium on F-FDG PET/CT and subsequently complicating as an occipital bleed. Read More
Neurol India 2018 Jul-Aug;66(4):1191-1193
Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Turk J Obstet Gynecol 2018 Jun 21;15(2):99-104. Epub 2018 Jun 21.
Süleyman Demirel University Faculty of Medicine, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Isparta, Turkey.
Objective: There is scarce information about axillary lymph node involvement in gynecologic cancers. We analyzed the incidence of suspicious axillary lymph nodes in gynecologic cancers.
Materials And Methods: We retrospectively analyzed the positron emission tomography/computed tomography findings of 251 patients with endometrial, cervical, and ovarian cancer. Read More
Endocrine 2018 09 15;61(3):489-498. Epub 2018 Jun 15.
Programa de Pós Graduação em Endocrinologia da Faculdade de Medicina da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Purpose: Evaluate the impact of TERTp mutation on the outcomes after initial treatment of 45 patients with thyroid carcinomas derived from follicular cells (TCDFC) with aggressive histology, in which the role of this mutation is not yet well defined.
Methods: Analysis of the presence of TERTp (-124C > T and -146C > T), BRAF (V600E), and NRAS (Q 61R) mutations by Sanger sequencing and analysis of their correlation with the patient's outcomes.
Results: Forty-five patients with aggressive histopathologic variants were included in the study. Read More
Med Princ Pract 2018 13;27(5):489-492. Epub 2018 Jun 13.
Department of Oral Surgery, BRS Dental College, Panchkula, India.
Objective: To present a case of lingual thyroid Hürthle cell carcinoma (HCC).
Clinical Presentation And Intervention: A 37-year-old female presented with dysphagia and recurrent haemorrhage. Histopathology was suggestive of HCC; the tumour was excised by the trans-glossal approach which provided adequate exposure and helped avert external scarring or mandibular osteotomy. Read More
Mol Imaging Radionucl Ther 2018 Jun;27(2):96-98
Shaukat Khanum Memorial Cancer Hospital and Research Centre, Department of Pathology, Lahore, Pakistan.
Thyroid incidentalomas are frequently reported on F-FDG PET/CT scan. High risk of malignancy is thought to be associated with increased metabolic activity and high standardized uptake value. Likewise, thyroid nodules with focal FDG avidity have a higher potential to be malignant. Read More
Head Neck Pathol 2018 May 31. Epub 2018 May 31.
Division of Pathology, Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.
IgG4-related disease of the thyroid gland is a recently recognized subtype of thyroiditis, often with rapid progression requiring surgical treatment. It is considered as a spectrum of disease varying from early IgG4-related Hashimoto's thyroiditis (HT) pattern to late fibrosing HT or Riedel's thyroiditis patterns. Here, we report a 47-year-old Malay woman presenting with progressively painless neck swelling over 3 years and subclinical hypothyroidism. Read More
Endocrine 2018 08 23;61(2):293-302. Epub 2018 May 23.
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Purpose: Preoperative distinction of follicular thyroid carcinoma (FTC) from follicular thyroid adenoma (FTA) is a diagnostic challenge. Our aim was to investigate whether the Ki-67 proliferation index in fine needle aspiration material can contribute to the diagnosis of FTC.
Methods: We analyzed retrospectively cytological Ki-67 index determined in routine clinical setting and clinical data for 61 patients with FTC, 158 patients with FTA and 15 patients with follicular tumor of uncertain malignant potential (FT-UMP) surgically treated and diagnosed by histopathology at Karolinska University Hospital 2006-2017 (Cohort A). Read More
Acta Cytol 2018 3;62(3):193-203. Epub 2018 May 3.
Objective: We aimed to review all cytological specimens with Hürthle cells (HC) diagnosed in our institution, identify cytological features related to neoplastic (adenoma or carcinoma) and malignant histology, and discuss the role of clinicopathological findings and clinical management in these cases.
Study Design: We included 359 thyroid fine-needle aspiration cytology cases in our study. We reviewed the clinical and cytological features of surgical cases and correlated them with histological diagnosis. Read More
Hum Pathol 2018 Nov 1;81:9-17. Epub 2018 May 1.
Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Follicular-patterned tumors of the thyroid gland are characterized by a predominantly follicular growth pattern. They frequently harbor RAS mutations, not BRAF mutations. Technological advances in molecular testing have discovered novel RAS-type mutations. Read More
Int J Endocrinol Metab 2018 Jan 31;16(1):e57897. Epub 2017 Oct 31.
MD, Endocrine Section, MedStar Washington Hospital Center, Washington, DC, 20010.
Background: The number of studies on venous thromboembolism (VTE) and thyroid cancer is very scarce and existing data are contradictory. This paper reviews VTE in thyroid cancer.
Methods: The following words were used for a comprehensive literature review using MEDLINE database: Blood coagulation factors; thyroid hormones; blood coagulation tests; venous thromboembolism; receptors thyroid hormone; hemostasis; fibrinolysis; bleeding; blood coagulation disorders; thyroid neoplasms; Thyroid cancer, papillary; Thyroid cancer, follicular; Thyroid carcinoma, anaplastic; Thyroid cancer, Hurthle cell; Familial medullary thyroid carcinoma; venous thrombosis; Pulmonary embolism; Blood coagulation factors. Read More
Mol Cancer Ther 2018 Jul 25;17(7):1575-1584. Epub 2018 Apr 25.
Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Next-generation sequencing (NGS) for molecular diagnostics allows simultaneous testing of activating oncogenes and tumor suppressor mutations in multiple signal pathways. Extended mutational profiling of advanced thyroid cancers may enhance considerations for targeted therapies. We analyzed clinically derived molecular profiling of 216 patients with advanced thyroid carcinoma using NGS (Ion Torrent Personal Genome Machine) from April 2012 to February 2014. Read More
J Thyroid Res 2018 1;2018:5246516. Epub 2018 Mar 1.
Department of Pathology, Dr. D. Y. Patil Medical College, Pimpri, Pune 411018, India.
Introduction: Different types of thyroiditis may share some parallel clinical and biochemical features. Timely intervention can significantly reduce morbidity and mortality.
Aim: Aim of this study is to find the frequency of various thyroiditis, study the cytomorphological features and correlate with clinical findings including radiological findings, thyroid function test, and anti-thyroid peroxidase antibodies (Anti-TPO antibodies). Read More
J Thyroid Res 2018 25;2018:6516035. Epub 2018 Feb 25.
Department of Pathology, Korle-Bu Teaching Hospital, P.O. Box 77, Korle-Bu, Accra, Ghana.
Background: Follicular thyroid cancer (FTC) has historically been linked to iodine deficiency. Although Ghana is among the iodine deficient regions of the world, the proportions, trends, and the clinical features of FTCs have not been studied as a single disease entity. The aim of this study was to determine the relative frequencies, trends, and the clinicopathological characteristics of FTCs among all thyroid malignancies in our institution. Read More
Oncotarget 2018 Mar 23;9(22):16273. Epub 2018 Mar 23.
Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
[This corrects the article DOI: 10.18632/oncotarget.20732. Read More
Int J Surg Pathol 2018 Sep 4;26(6):521-524. Epub 2018 Apr 4.
1 The Royal Marsden NHS Foundation Trust, London, UK.
We illustrate a case of synchronous malignant solitary fibrous tumor of the thoracic cavity, and widely invasive thyroid Hurthle cell carcinoma. The Hurthle cell carcinoma was found to harbor distinct areas of malignant solitary fibrous tumor. This is a unique case of tumor-to-tumor metastasis that, to the best of our knowledge, has not been previously reported. Read More
Gulf J Oncolog 2018 Jan;1(26):6-10
Department of Pathology, Regional Cancer Centre, Thiruvananthapuram, India.
Introduction: Lesions of the thyroid gland composed of Hurthle cells constitute a wide spectrum of pathological entities ranging from benign hyperplastic nodules with Hurthle cell metaplasia at one end to malignancies like Hurthle cell carcinomas. The cytological distinction of these entities is not only diagnostically challenging but are also critical since they influence treatment decisions.
Aim: To critically analyze the cytomorphology of cases of Hurthle cell lesions in FNACs and to characterize cytological features shown to be statistically signific ant in predicting Hurthle cell neoplasm (HCN). Read More
North Clin Istanb 2018 10;5(1):67-71. Epub 2018 Jan 10.
Department of General Surgery, Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey.
A 22-year-old patient underwent fine needle aspiration of a nodule at the outer center of the right lobe of the thyroid, and it was reported to be Bethesda system category IV, Hurthle cell follicular neoplasia. The patient, who persented to Onsekiz Mart University Research and Application Hospital, underwent surgery. During right total thyroidectomy, an almost totally infarcted nodule and papillary structures around these infarcted areas were detected. Read More
Cancer Cytopathol 2018 Jun 26;126(6):406-413. Epub 2018 Mar 26.
Division of Pathology and Laboratory Medicine, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Background: The identification of BRAF mutations in thyroid cancer has prognostic and therapeutic implications. Although the gold standard for identifying BRAF mutations is molecular testing, the ability to perform BRAF p.V600E immunostaining on fine-needle aspiration (FNA) samples can facilitate the rapid triaging of patients to treatment options. Read More
Oncol Lett 2018 Apr 17;15(4):4511-4516. Epub 2018 Jan 17.
Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
HRas proto-oncogene () is one of the most commonly mutated genes in thyroid cancer, with mutations frequently occurring in the follicular and Hurthle cell subtypes. However, the contribution of mutations in to papillary thyroid carcinoma (PTC) progression and the tall-cell variant (TCV) is poorly understood. The aim of the present study was to investigate the somatic genetic variants present in in patients with PTC, and to investigate the association of these mutations with PTC. Read More
Endocr Pract 2018 May 2;24(5):453-459. Epub 2018 Mar 2.
Objective: Circulating tumor DNA (ctDNA), a subset of cell-free DNA (cfDNA), is a potential biomarker for thyroid cancer. We determined the performance of a ctDNA panel for detecting thyroid malignancy in patients with thyroid nodules.
Methods: Sixty-six patients with thyroid nodules without a prior history of cancer enrolled in a prospective, 1-year study in which blood was drawn for ctDNA analysis prior to undergoing fine-needle aspiration biopsy (FNAB) of thyroid nodules. Read More
Ann R Coll Surg Engl 2018 May 27;100(5):357-365. Epub 2018 Feb 27.
First Department of General Surgery and Transplantation, 'Evangelismos' General Hospital , Athens , Greece.
Introduction The purpose of this study was to evaluate the incidence of incidental differentiated thyroid carcinoma in thyroid operations for a benign preoperative diagnosis, to identify the risk factors involved and to risk stratify the cancer patients according to the 2015 American Thyroid Association (ATA) guidelines. Materials and methods The study was a retrospective review of all thyroidectomy operations performed in a single institution (January 2004 to January 2009). We excluded patients with a preoperative diagnosis of thyroid malignancy. Read More
Cancer Cytopathol 2018 May 22;126(5):317-325. Epub 2018 Feb 22.
Department of Public Health, Federico II University of Naples, Naples, Italy.
Background: The Bethesda System for Reporting Thyroid Cytopathology category of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) includes fine-needle aspiration (FNA) specimens that cannot straightforwardly be classified as benign or malignant. To determine whether morphological subcategorization based on atypia qualifiers and molecular testing could improve malignancy risk stratification of AUS/FLUS patients, this study assessed the correlation between these qualifiers and the molecular alterations commonly harbored by thyroid neoplasms.
Methods: A total of 162 AUS/FLUS cases were subcategorized by atypia qualifiers (Hürthle cell changes, architectural atypia, and cytologic atypia [CyA]) and were tested for BRAF, N-H-KRAS, RET/PTC, and paired box 8 (PAX8)/peroxisome proliferator activated receptor γ (PPARg) mutations. Read More
Endocrinol Diabetes Nutr 2018 Mar 9;65(3):136-142. Epub 2018 Feb 9.
Facultad de Ciencias de la Salud, Universidad Pública de Navarra, Pamplona, Navarra, España.
Introduction: Hürthle cell carcinoma (HCC) is an uncommon thyroid cancer historically considered to be a variant of follicular thyroid carcinoma (FTC). The aim of this study was to assess the differences between these groups in terms of clinical factors and prognoses.
Patients And Methods: A total of 230 patients (153 with FTC and 77 with HCC) with a median follow-up of 13. Read More
J Pathol Transl Med 2018 Mar 12;52(2):105-109. Epub 2018 Feb 12.
Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Background: Warthin-like variant of papillary thyroid carcinoma (WLV-PTC) is a relatively rare variant of papillary thyroid carcinoma with favorable prognosis. However, preoperative diagnosis using fine-needle aspiration (FNA) specimens is challenging especially with lymphocytic thyroiditis characterized by Hürthle cells and lymphocytic background. To determine a helpful cytological differential point, we compared WLV-PTC FNA findings with conventional papillary thyroid carcinoma with lymphocytic thyroiditis (PTC-LT) and conventional papillary thyroid carcinoma without lymphocytic thyroiditis (PTC) regarding infiltrating inflammatory cells and their distribution. Read More
Cancer Cytopathol 2018 May 9;126(5):309-316. Epub 2018 Feb 9.
Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.
Background: The recent revision in terminology, with noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) replacing noninvasive follicular variant of papillary thyroid carcinoma, has reclassified the clinically indolent tumor as nonmalignant. The objective of this study was to evaluate the impact of this change on the rate of malignancy (ROM) for subcategories of an atypia of undetermined significance (AUS) diagnosis on fine-needle aspiration (FNA) cytology.
Methods: Consecutive thyroid FNAs interpreted as AUS over a period of 4 years were retrospectively analyzed. Read More
Appl Immunohistochem Mol Morphol 2018 Feb 5. Epub 2018 Feb 5.
Department of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
There is a great interest in molecular markers that would help in the preoperative diagnosis of malignant thyroid nodules in cases of indeterminate fine-needle aspiration cytology. The aim of this study was to determine the diagnostic accuracy of HMGA2 gene expression in discriminating benign from malignant thyroid nodules. In this study, 237 preoperative thyroid fine-needle aspiration samples were analyzed prospectively for the expression of the HMGA2 gene by real-time reverse transcription polymerase chain reaction. Read More
Endocrinol Diabetes Nutr 2018 03 7;65(3):133-135. Epub 2018 Feb 7.
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal; Department of Pathology, Hospital São João, Porto, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal; i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal.