Search our Database of Scientific Publications and Authors

I’m looking for a

    1045 results match your criteria Hurthle Cell Carcinoma

    1 OF 21

    THYROID CANCER CONSEQUENCES OF IODINE DEFICIENCY - A PERSISTING WORLDWIDE PROBLEM: CHARACTERISTICS IN DIFFERENT POPULATIONS, PORTUGAL AND SOUTH AFRICA.
    S Afr J Surg 2017 Sep;55(3):69
    University of Beira Interior, and Centro Hospitalar Cova da Beira, Hospital da Covilhã, and CICS-UBI Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior.
    Background: Iodine deficiency (ID) still affects over two billion people worldwide (266 million school aged children). Pathology patterns in ID include: increase in thyroid cancer, higher percentages of follicular and anaplastic cancers and inversion of the papillary/follicular thyroid cancer frequency ratio. China succeeded in eliminating ID through legislation introduced in 1987 aimed at availability of iodized salt countrywide and South Africa through legislation introduced in 1995. Read More

    Impact of Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Features on Adequacy Criteria and Risk of Malignancy of Thyroid Fine-Needle Aspiration.
    Am J Clin Pathol 2017 Sep;148(3):259-263
    Department of Pathology, Baptist Hospital, Miami, FL.
    Objectives: The impact of noninvasive follicular thyroid neoplasm with papillary-like features (NIFTP) on nondiagnostic and benign diagnoses is not well characterized.

    Methods: The results of all thyroid fine-needle aspirates (FNAs) performed from 1997 to June 2016 with corresponding resections were reviewed.

    Results: From 12,764 aspirates, there were 8,106 (64%) benign diagnoses with 412 (5%) resections and 1,888 (14. Read More

    Oncocytic variant of medullary thyroid carcinoma; a rare tumor with numerous diagnostic mimics by fine needle aspiration.
    Diagn Cytopathol 2017 Aug 12. Epub 2017 Aug 12.
    Department of Pathology, University of Colorado at Denver and Health Sciences Center, Aurora, CO, 80045.
    Oncocytic variant of medullary thyroid carcinoma is rare form of thyroid carcinoma that is easily misdiagnosed on fine needle aspiration specimens due to it is low incidence and cytomorphologic overlap with other more common Hurtle cell lesions. A correct initial diagnosis by fine needle aspiration is imperative as the clinical treatment for medullary carcinoma differs significantly from the mimickers. We present a case of this rare variant tumor that on initial fine needle aspiration was described as a Hurthle cell lesion and was subsequently correctly classified on the resection specimen. Read More

    Aggressive differentiated thyroid cancer with multiple metastases and NRAS and TERT promoter mutations: A case report.
    Oncol Lett 2017 Aug 16;14(2):2186-2190. Epub 2017 Jun 16.
    Endocrinology Unit, Department of Medical Sciences 'M. Aresu', University of Cagliari and University Hospital of Cagliari, I-09042 Cagliari, Italy.
    Sorafenib, a tyrosine kinase inhibitor, is approved for the treatment of advanced differentiated thyroid carcinoma (DTC). Resistance to sorafenib may appear under treatment and may be associated with increased aggressiveness of the neoplasia. The present study reports the case of a 65-year-old male who underwent total thyroidectomy for a follicular thyroid carcinoma, Hürthle cell variant, in February 2005. Read More

    Size of thyroid carcinoma by histotype and variants: A population-based study in a mildly iodine-deficient area.
    Head Neck 2017 Oct 24;39(10):2095-2103. Epub 2017 Jul 24.
    Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy.
    Background: Data relating the size of thyroid cancer with histological types and variants are scarce.

    Methods: All incident thyroid cancer diagnosed between 2003 and 2012 in a mildly iodine-deficient area were derived from a population-based tumor registry. Undifferentiated/anaplastic thyroid cancer and incidental cases were excluded. Read More

    Phosphorylated Mechanistic Target of Rapamycin (p-mTOR) and Noncoding RNA Expression in Follicular and Hürthle Cell Thyroid Neoplasm.
    Endocr Pathol 2017 Jun 28. Epub 2017 Jun 28.
    Department of Pathology and Laboratory Medicine, University of Wisconsin, School of Medicine and Public Health, 600 Highland Ave, Box 8550, Madison, WI, 53792, USA.
    Oncocytic (Hürthle cell) and follicular neoplasms are related thyroid tumors with distinct molecular profiles. Diagnostic criteria separating adenomas and carcinomas for these two types of neoplasms are similar, but there may be some differences in the biological behavior of Hürthle cell and follicular carcinomas. Recent studies have shown that noncoding RNAs may have diagnostic and prognostic utility in separating benign and malignant Hürthle cell and follicular neoplasms. Read More

    Evolution of the histologic classification of thyroid neoplasms and its impact on clinical management.
    Eur J Surg Oncol 2017 May 18. Epub 2017 May 18.
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:
    The vast majority of low grade follicular cell derived thyroid carcinomas follows an indolent clinical course and is associated with very low mortality. Risk stratification using multiple clinical and pathologic characteristics has become the standard of care to guide appropriate management and avoid overtreatment. Over the past few decades, the field of thyroid pathology has witnessed several major changes that significantly impacted upon patients' care. Read More

    Survival and prognostic factors for survival, cancer specific survival and disease free interval in 239 patients with Hurthle cell carcinoma: a single center experience.
    BMC Cancer 2017 May 25;17(1):371. Epub 2017 May 25.
    Center for Endocrine Surgery, Clinical Center of Serbia, Pasterova 2, Belgrade, 11000, Serbia.
    Background: Hurthle cell carcinoma makes up 3 to 5% of all thyroid cancers and is considered to be a true rarity. The aim of our study was to analyze clinical characteristics and survival rates of patients with Hurthle cell carcinoma.

    Methods: Clinical data regarding basic demographic characteristics, tumor grade, type of surgical treatment and vital status were collected. Read More

    PSMA Expression in Multinodular Thyroid Neoplasm on Simultaneous Ga-68-PSMA PET/MRI.
    Indian J Nucl Med 2017 Apr-Jun;32(2):159-161
    Department of Molecular Imaging and Nuclear Medicine, Indraprastha Apollo Hospitals, Sarita Vihar, New Delhi, India.
    PSMA PET is increasingly being used in imaging of recurrent prostate carcinoma. A case with suspected recurrent Prostate carcinoma (PCa), raised PSA (Prostate specific antigen) and suspected spinal metastases was referred for whole body Ga-68-PSMA PET/MRI. The study revealed PSMA avid recurrent prostate mass and extensive osseous metastases. Read More

    Hashimoto's thyroiditis associated with thyroid adenoma with Hürthle cells - case report.
    Rom J Morphol Embryol 2017 ;58(1):241-248
    Department of Endocrinology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;
    Chronic thyroiditis may present a focal lesion, often-palpable abnormality, simulating nodular disease. The number and morphology of the Hürthle cells (HC) vary in the thyroid aspirate. Distinguishing between neoplastic and non-neoplastic HC lesions is difficult when using the fine-needle aspiration cytology (FNAC). Read More

    Issues in Managing Hurthle Cell Carcinoma of Thyroid: A Case Report.
    Cureus 2017 Apr 14;9(4):e1167. Epub 2017 Apr 14.
    Oncology, Kingston General Hospital and Hotel Dieu Hospital, Queens University.
    A 61-year-old woman noticed a right neck lump in October 2001. Fine needle aspiration showed follicular neoplasm, adenoma versus carcinoma. The ultrasound scan showed a solid mass of maximum dimension of 3. Read More

    Metastatic Follicular Thyroid Carcinoma and the Primary Thyroid Gross Examination: Institutional Review of Cases from 1990 to 2015.
    Endocr Pathol 2017 Jun;28(2):177-185
    Pathology Service, WRN219, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
    The diagnosis of follicular-patterned carcinomas, including follicular thyroid carcinoma, oncocytic (Hürthle cell) carcinoma, and the encapsulated follicular variant of papillary thyroid carcinoma, requires evidence of capsular and/or vascular invasion. With minimally invasive carcinomas classified often within less than a millimeter of tissue segregating them from adenomas and non-invasive follicular thyroid neoplasms with papillary-like nuclear features, opinions vary internationally over how much of the capsule to submit in order to deem it well enough represented, considering that even if grossly entirely submitted in microcassettes, without leveling through each tissue block, the capsule is truly never entirely examined microscopically. Here, we retrospectively examine submission practices and outcomes at a single, high-volume institution over a 25-year period. Read More

    Aberrant Intrathyroid Tissue: a Report of Intrathyroid Lymph Node Metastasis and a Review of Literature.
    Indian J Surg 2017 Apr 20;79(2):148-152. Epub 2017 Jan 20.
    Department of Surgery, Waikato Hospital, Hamilton, New Zealand.
    Aberrant histological elements have been infrequently reported to exist within the intact thyroid gland. In addition to distant metastases to the thyroid, a number of ectopic tissue rests and unusual cysts have been described within the thyroid gland. In this article, we report the presence of a true intrathyroid lymph node and describe the first reported case of intrathyroid lymph node metastasis of papillary thyroid cancer. Read More

    Parotid gland involvement as an initial presentation of papillary thyroid carcinoma.
    Int J Oral Maxillofac Surg 2017 Aug 22;46(8):965-967. Epub 2017 Apr 22.
    Department of Pathology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
    Papillary thyroid carcinoma (PTC) is the most differentiated malignant thyroid neoplasm. Local metastases of PTC commonly occur in the regional lymph nodes, while distant metastases are mainly to the lung and bone. The case of a patient with PTC who presented with swelling of the parotid gland and neck, mimicking a primary parotid neoplasm, is presented herein. Read More

    Nodular oncocytic hyperplasia: Can cytomorphology allow for the preoperative diagnosis of a nonneoplastic salivary disease?
    Cancer 2017 Aug 14;125(8):627-634. Epub 2017 Apr 14.
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.
    Background: Nodular oncocytic hyperplasia (oncocytosis) of the salivary glands is a benign process that does not inherently require surgical excision. However, cytologic findings in fine-needle aspiration (FNA) of oncocytosis cases have not been well characterized previously, limiting preoperative identification.

    Methods: All available cases of oncocytosis with corresponding FNA specimens were identified from the pathology archives of 3 academic institutions. Read More

    Improving Access to Image-guided Procedures at an Integrated Rural Critical Access Hospital: Ultrasound-guided Thyroid Biopsy Program.
    Curr Probl Diagn Radiol 2017 Feb 16. Epub 2017 Feb 16.
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Electronic address:
    Purpose: Critical access hospitals face difficulty providing all services locally and may need to refer patients off-site for additional care. Providing on-site minimally invasive biopsies, may obviate visits to tertiary or quaternary care centers. This study aims to assess feasibility and outcomes of an ultrasound-guided thyroid biopsy program in a critical access hospital. Read More

    Risk of Malignancy and Risk of Neoplasia in the Bethesda Indeterminate Categories: Study on 4,532 Thyroid Fine-Needle Aspirations from a Single Institution in India.
    Acta Cytol 2017 14;61(2):103-110. Epub 2017 Apr 14.
    Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Objectives: To determine the frequency of category 3 (atypia of undetermined significance [AUS]/follicular lesion of undetermined significance [FLUS]), category 4 (follicular neoplasm), and category 5 (suspicious for malignancy) of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), the risk of malignancy (ROM) and the risk of neoplasia (RON) in these categories.

    Study Design: A retrospective 6-year audit of 4,532 thyroid fine-needle aspirations (FNA) reported as per the TBSRTC from a single institution with cytohistological correlation in 335 cases.

    Results: The frequency of categories 3, 4, and 5 was 2. Read More

    Parathyroid Adenomas in Adults and Adolescents. Critical Appraisal and Surgical Strategy in 18 Cases.
    Chirurgia (Bucur) 2017 Jan-Feb;112(1):18-24
    Background: Our study underline scarcity of isolated case reports or small case series of parathyroid adenoma (PA) published in autochthonous medical literature,their variable clinical expression among the "historic" varieties but also the diagnostic difficulties and delays of diagnosis as well consecration of surgery as the golden therapeutic standard of this disorder.

    Patients And Method: Demographic, clinical presentations, laboratory and imaging data, operative findings and procedures together with pathology account and outcome from the case reports of 18 patients with documented PHP were retrospectively analyzed. Results: The male/female ratio was 1/5, with ages ranging from 16 to 58 (mean 46) years. Read More

    Cytological evaluation by fine needle aspiration biopsy of incidental focal increased fluorodeoxyglucose uptake in thyroid on positron emission tomography scan.
    Diagn Cytopathol 2017 Jun 6;45(6):501-506. Epub 2017 Mar 6.
    Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
    Background: With the increased use of whole body fluorodeoxyglucose positron emission tomography (PET) scan for staging/restaging or primary diagnosis of neoplasia, thyroid incidentalomas have become more common. The limited reports of PET-positive thyroid incidentalomas showed incidence of malignancy ranging from 14 to 66%, and there is discrepancy in terms of the diagnostic significance of the standard uptake value (SUV) value.

    Methods: This is a retrospective study of 20 PET incidentalomas which had cytological evaluation from October 2009 to February 2015 at a tertiary care university medical center, M:F = 8:12. Read More

    Diagnostic utility of CK19 and CD56 in the differentiation of thyroid papillary carcinoma from its mimics.
    Pathol Res Pract 2017 May 22;213(5):509-517. Epub 2017 Jan 22.
    Department of Pathology,Ahmed Maher Teaching Hospital, Cairo, Egypt.
    Background: Papillary Thyroid Carcinoma (PTC) is the most common type of malignant thyroid tumors. The main diagnostic clue of PTC is the presence of its characteristic nuclear features. Yet, the focal presence of these features in other thyroid lesions causes a diagnostic dilemma. Read More

    How "suspicious" is that nodule? Review of "suspicious" Afirma gene expression classifier in high risk thyroid nodules.
    Diagn Cytopathol 2017 Apr 11;45(4):308-311. Epub 2017 Feb 11.
    Department of Pathology, Hofstra Northwell Health School of Medicine, Lake Success, New York.
    Background: The Afirma gene expression classifier (GEC) is being increasingly utilized to confirm the benign nature of indeterminate FNA cytology results thus avoiding unnecessary surgical procedures. However the "suspicious" result of the Afirma GEC does not classify these indeterminate nodules further in determining appropriate management. This study investigated the outcome of the thyroid nodules deemed to be "suspicious" by the Afirma GEC in a high risk population. Read More

    GAUGING THE EXTENT OF THYROIDECTOMY FOR INDETERMINATE THYROID NODULES: AN ONCOLOGIC PERSPECTIVE.
    Endocr Pract 2017 Apr 17;23(4):442-450. Epub 2017 Jan 17.
    Objective: Increasing emphasis is being placed on appropriateness of care and avoidance of over- and under-treatment. Indeterminate thyroid nodules (ITNs) present a particular risk for this problem because cancer found via diagnostic lobectomy (DL) often requires a completion thyroidectomy (CT). However, initial total thyroidectomy (TT) for benign ITN results in lifelong thyroid hormone replacement. Read More

    Primary Thyroid Carcinoma with Low-Risk Histology and Distant Metastases: Clinicopathologic and Molecular Characteristics.
    Thyroid 2017 May 1;27(5):632-640. Epub 2017 Feb 1.
    1 Department of Pathology, Memorial Sloan-Kettering Cancer Center , New York, New York.
    Background: Distant metastases (DM) are a rare occurrence in well-differentiated thyroid carcinoma. The aim of this study was to analyze the clinical, pathologic, and molecular features of primary thyroid carcinoma with low-risk histology that develop DM.

    Methods: A detailed clinicopathologic review and targeted next-generation sequencing were performed on a cohort of well-differentiated thyroid carcinoma lacking gross extrathyroidal extension, extensive vascular invasion, or significant lymph node metastases but exhibiting DM. Read More

    Analysis of malignancy predictors for oxyphile thyroid tumors.
    J BUON 2016 Nov-Dec;21(6):1496-1500
    Surgical Clinic, Clinical Center "Dr Dragisa Misovic-Dedinje", Belgrade, Serbia.
    Purpose: In contrast to other thyroid carcinomas it is difficult to establish a correct preoperative diagnosis for oxyphile carcinoma of the thyroid. In this study we looked for predictive malignancy factors in order to enable surgeons to choose operative treatment and to perform an adequate operation for each patient with an oxyphile neoplasm of the thyroid.

    Methods: In this retrospective study we have analyzed the medical files of all patients with oxyphile tumors of the thyroid operated between 1999 and 2008 in our institution. Read More

    A rare case of cutaneous oncocytic hidradenoma.
    J Cutan Pathol 2017 Mar 2;44(3):289-291. Epub 2017 Feb 2.
    Departments of Dermatology and Pathology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California.
    Oncocytes are epithelial cells characterized by their abundant eosinophilic and finely granular cytoplasm. Their histologic appearance is due to excessive amounts of cytoplasmic mitochondria. Oncocytes generally occur in the setting of benign neoplasms. Read More

    Thyroid FNAC containing hürthle cells and hürthle-like cells: A study of 128 cases.
    J Cytol 2016 Oct-Dec;33(4):214-219
    Department of Pathology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
    Aim: It is a diagnostic challenge to differentiate benign and malignant cytology in the presence of Hürthle cells. In our previous study, it was determined that in fine needle aspirations (FNA), the malignancy outcome of the Hürthle cells containing group tend to be papillary thyroid carcinoma (PTC) in a higher percentage. The most common misinterpretation is caused by PTC cells with large cytoplasm-like Hürthle cells. Read More

    Most Thyroid Cancers Detected by Sonography Lack Intranodular Vascularity on Color Doppler Imaging: Review of the Literature and Sonographic-Pathologic Correlations for 698 Thyroid Neoplasms.
    J Ultrasound Med 2017 Jan 1;36(1):89-94. Epub 2016 Dec 1.
    Lenox Hill Radiology, New York, New York, USA.
    Objectives: This study investigated the controversy of whether hypervascularity on color Doppler sonography correlates with thyroid malignancy by reviewing the literature and sonographic-pathologic correlation.

    Methods: Over a 20-year period, 698 thyroid nodules had color Doppler and histopathologic data. Intranodular vascularity was graded 0 to 3+, and histopathologic findings were recorded. Read More

    Imaging Surveillance in Patients After a Benign Fine-Needle Aspiration Biopsy of the Thyroid: Associated Cost and Incidence of Subsequent Cancer.
    AJR Am J Roentgenol 2017 Feb 8;208(2):358-361. Epub 2016 Dec 8.
    1 Department of Radiology, Thomas Jefferson University, Philadelphia, PA.
    Objective: The objective of our study was to determine patterns and cost of imaging tumor surveillance in patients after a benign fine-needle aspiration (FNA) biopsy of the thyroid in a large teaching hospital as well as the rate of subsequent cancer detection.

    Materials And Methods: This cohort study was approved by the appropriate institutional review board and complied with HIPAA. All patients who had a benign thyroid FNA biopsy between January 1, 1999, and December 31, 2003, were identified from an institutional pathology database. Read More

    Clinicopathological features of thyroid cancer in the elderly compared to younger counterparts: single-center experience.
    J Endocrinol Invest 2017 May 24;40(5):471-479. Epub 2016 Nov 24.
    Department of Endocrinology and Metabolism, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.
    Purpose: The incidence of thyroid cancer is increased in elderly patients. It tends to be larger and have more aggressive characteristics in these patients. Our aim was to compare features of thyroid carcinoma in geriatric and non-geriatric patients. Read More

    Hürthle cell carcinoma: current perspectives.
    Onco Targets Ther 2016 7;9:6873-6884. Epub 2016 Nov 7.
    Section of Endocrine Surgery, Department of Surgery; Duke Cancer Institute; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
    Hürthle cell carcinoma (HCC) can present either as a minimally invasive or as a widely invasive tumor. HCC generally has a more aggressive clinical behavior compared with the other differentiated thyroid cancers, and it is associated with a higher rate of distant metastases. Minimally invasive HCC demonstrates much less aggressive behavior; lesions <4 cm can be treated with thyroid lobectomy alone, and without radioactive iodine (RAI). Read More

    Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy.
    Oncotarget 2016 Nov;7(48):79117-79130
    Research Center for Endocrine and Metabolic Diseases, Division of Endocrinology, Department of Internal Medicine, Chungnam National University School of Medicine, Jung-gu, Daejeon 35015, Republic of Korea.
    Primary cilia are found in the apical membrane of thyrocytes, where they may play a role in the maintenance of follicular homeostasis. In this study, we examined the distribution of primary cilia in the human thyroid cancer to address the involvement of abnormal ciliogenesis in different thyroid cancers. We examined 92 human thyroid tissues, including nodular hyperplasia, Hashimoto's thyroiditis, follicular tumor, Hürthle cell tumor, and papillary carcinoma to observe the distribution of primary cilia. Read More

    Analytical Performance of a Gene Expression Classifier for Medullary Thyroid Carcinoma.
    Thyroid 2016 Nov;26(11):1573-1580
    1 Veracyte, Inc. , South San Francisco, California.
    Background: The aim of this study was to demonstrate the analytical validity of an RNA classifier for medullary thyroid carcinoma (MTC).

    Methods: Fresh-frozen tissue specimens were obtained from commercial sources, and MTC diagnoses were confirmed by histopathology review. De-identified patient fine-needle aspiration biopsies (FNABs) and whole blood from normal donors were obtained. Read More

    Clinicopathologic Features of Fatal Non-Anaplastic Follicular Cell-Derived Thyroid Carcinomas.
    Thyroid 2016 Nov 7;26(11):1588-1597. Epub 2016 Sep 7.
    1 Department of Pathology, Memorial Sloan Kettering Cancer Center , New York, New York.
    Background: The vast majority of thyroid cancers, in particular the non-anaplastic follicular cell-derived thyroid carcinomas (non-ANA FCDC), are considered indolent tumors with very low mortality. Hence, it is crucial to analyze the subgroup of these patients who die of disease (DOD) in order to identify clinicopathologic features predictive of disease-specific mortality.

    Methods: All non-ANA FCDC operated at a tertiary cancer center between 1985 and 2010 who were DOD were identified and submitted to a meticulous clinicopathologic analysis. Read More

    Functional polymorphisms in antioxidant genes in Hurthle cell thyroid neoplasm - an association of GPX1 polymorphism and recurrent Hurthle cell thyroid carcinoma.
    Radiol Oncol 2016 Sep 19;50(3):289-96. Epub 2016 Jul 19.
    Institute of Oncology Ljubljana, Slovenia.
    Background: Hurthle cells of the thyroid gland are very rich in mitochondria and oxidative enzymes. As a high level oxidative metabolism may lead to higher level of oxidative stress and can be associated with an increased risk for cancer, we investigated whether common functional polymorphisms in antioxidant genes (SOD2, CAT, GPX, GSTP1, GSTM1 and GSTT1) are associated with the development or clinical course of Hurthle cell thyroid carcinoma (HCTC).

    Methods: A retrospective study was performed in 139 patients treated by thyroid surgery for a Hurthle cell neoplasm. Read More

    Recurrence rate in regional lymph nodes in 737 patients with follicular or Hürthle cell neoplasms.
    Radiol Oncol 2016 Sep 19;50(3):269-73. Epub 2016 Jul 19.
    Department of Radiology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
    Background: Preoperative ultrasound (US) evaluation of central and lateral neck compartments is recommended for all patients undergoing a thyroidectomy for malignant or suspicious for malignancy cytologic or molecular findings. Our aim was to find out how frequent was recurrence in regional lymph nodes in patients with follicular or Hürthle cell neoplasm and usefulness of preoperative neck US investigation in patients with neoplasm.

    Patients And Methods: Altogether 737 patients were surgically treated because of follicular or Hürthle cell neoplasms from 1995 to 2014 at our cancer comprehensive center, among them 207 patients (163 females, 44 males; mean age 52 years) had thyroid carcinoma. Read More

    Comparison of Ultrasound, Pathologic and Prognostic Characteristics of the Follicular Variant of Papillary Thyroid Cancer According to Fine-Needle Aspiration Cytology.
    Ultrasound Med Biol 2016 Dec 19;42(12):2864-2872. Epub 2016 Sep 19.
    Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. Electronic address:
    The aim of the study described here was to compare ultrasound features, pathologic characteristics and prognoses of the follicular variant of papillary thyroid carcinoma (FVPTC) according to cytology results. Eighty-seven FVPTCs were classified according to the first cytology results as the surgery group (n = 66, follicular neoplasm/Hürthle cell neoplasm, suspicious for malignancy and malignancy) and the indeterminate group (n = 21, non-diagnostic and benign), for whom the management was follow-up. The indeterminate group had a longer mean interval to surgery (p = 0. Read More

    Submandibular oncocytic carcinoma: A case report and literature review.
    Medicine (Baltimore) 2016 Sep;95(37):e4897
    aDepartment of Pathology bCollege of Basic Medical Sciences, Gannan Medical University cDepartment of Stomatology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, P.R. China.
    Background: Oncocytic carcinoma (OC) arising in the submandibular gland is an unusual malignant neoplasm, with <20 cases previously reported. The cancer is characterized by numerous morphologically abnormal mitochondria present in the cytoplasm and marked cellular pleomorphism. At its most severe, the tumor may invade into the surrounding tissues, including intravascular, lymphatic, or perineural invasion, and lead to regional nodal or distant metastasis. Read More

    Expression of miRNA and Occurrence of Distant Metastases in Patients with Hürthle Cell Carcinoma.
    Int J Endocrinol 2016 28;2016:8945247. Epub 2016 Jul 28.
    Department of Surgical Oncology, Institute of Oncology, Zaloska 2, SL-1000, Ljubljana, Slovenia.
    Background. Hürthle cell thyroid carcinoma (HCTC) is a rare type of thyroid carcinoma. In the present study, we investigated whether the expression of miRNAs of interest is associated with the occurrence of metastases in patients with HCTC. Read More

    23 Lung Metastases Treated by Radiofrequency Ablation Over 10 Years in a Single Patient: Successful Oncological Outcome of a Metastatic Cancer Without Altered Respiratory Function.
    Cardiovasc Intervent Radiol 2016 Dec 8;39(12):1779-1784. Epub 2016 Aug 8.
    Department of Radiology, Institut Bergonié, 229 cours de l'Argonne, 33076, Bordeaux Cedex, France.
    An 82-year-old man, who was diagnosed in 2002 with an oncocytic (Hürthle cell) thyroid carcinoma, was initially treated by local surgery and was refractory to radioiodine treatment. The patient had successive secondary recurrences from 2006 onwards. Metastases were suspected due to an elevation of thyroglobulin in serum. Read More

    PVALB diminishes [Ca2+] and alters mitochondrial features in follicular thyroid carcinoma cells through AKT/GSK3β pathway.
    Endocr Relat Cancer 2016 Sep 25;23(9):769-82. Epub 2016 Jul 25.
    Genetic Bases of Thyroid Tumors LaboratoryDivision of Genetics, Department of Morphology and Genetics, Universidade Federal de São Paulo, São Paulo, Brazil
    We have identified previously a panel of markers (C1orf24, ITM1 and PVALB) that can help to discriminate benign from malignant thyroid lesions. C1orf24 and ITM1 are specifically helpful for detecting a wide range of thyroid carcinomas, and PVALB is particularly valuable for detecting the benign Hürthle cell adenoma. Although these markers may ultimately help patient care, the current understanding of their biological functions remains largely unknown. Read More

    A phase II trial of valproic acid in patients with advanced, radioiodine-resistant thyroid cancers of follicular cell origin.
    Clin Endocrinol (Oxf) 2017 Jan 8;86(1):128-133. Epub 2016 Sep 8.
    Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
    Objective: Valproic acid (VA) is a histone deacetylase (HDAC) inhibitor that has antiproliferative effects on several types of cancer, including thyroid cancer. In addition, VA has been reported to upregulate the sodium-iodine symporter in thyroid cancer cells and increases radioiodine uptake in preclinical studies. The aim of this study was to assess the antiproliferative effects of VA and to evaluate if VA can increase the radioiodine uptake in patients with advanced, radioiodine-negative thyroid cancer. Read More

    Malignancy risk of oncocytic changes in thyroid nodules: who should we offer surgery to?
    Acta Chir Belg 2016 Feb;116(1):30-5
    a Department of General Surgery , Sisli Etfal Training and Research Hospital , Istanbul , Turkey ;
    Background Oncocytic (Hürthle) cell in fine-needle aspiration biopsy (FNAB) remains challenging for surgeons. Surgical treatment is recommended for oncocytic change in FNAB, since it can sometimes be a struggle to determine the nature of thyroid nodules. We aimed to investigate the clinical significance of oncocytic changes in FNAB in terms of management of patients. Read More

    [Paratracheal lymph node with suspicion of carcinoma].
    Pathologe 2016 Sep;37(5):473-6
    Dr. Senckenbergisches Institut für Pathologie, Klinikum der J. W. Goethe Universität Frankfurt am Main, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland.
    Three paratracheal lymph nodes of a 20-year-old patient were submitted for examination, of which one showed numerous thyrocytes with large void nuclei and was suspected of being metastatic papillary thyroid carcinoma. The simultaneously resected thyroid gland, which was subsequently submitted showed findings consistent with Hashimoto's autoimmune thyroiditis (AIT). In the context of the resected goiter tissue, the suspected lymph node metastasis was identified as a hyperplastic ectopic (so-called parasitic) goiter nodule with thyrocytic changes typically seen in Hashimoto's AIT, such as oxyphilic cell alterations and a high plasma cell content. Read More

    Impact of specific patterns on the sensitivity for follicular and Hurthle cell carcinoma in thyroid fine-needle aspiration.
    Cancer 2016 Oct 20;124(10):729-736. Epub 2016 Jun 20.
    Department of Pathology, Baptist Hospital, Miami, Florida.
    Background: To the authors' knowledge, the impact of specific cytologic patterns in thyroid fine-needle aspiration (FNA) for follicular and Hurthle cell carcinoma is not known.

    Methods: The results of all thyroid FNAs performed from 1997 through 2015 with corresponding resections of follicular and Hurthle cell carcinomas were reviewed.

    Results: A total of 24 follicular carcinomas and 35 Hurthle cell carcinomas were identified. Read More

    Frequency of thyroid cancer in patients operated at Cantonal Hospital Zenica, Bosnia and Herzegovina, in the period 2007-2014.
    Med Glas (Zenica) 2016 Aug;13(2):113-7
    Ear, Nose and Throat Department, Cantonal Hospital Zenica, Bosnia and Herzegovina.
    Aim To determine frequency and type of thyroid cancer (TC) as well as gender and age distribution of patients operated at the Department of Ear, Nose and Throat (ENT), Cantonal Hospital Zenica, Bosnia and Herzegovina. Methods A retrospective analysis of data obtained from an operating protocol and disease history of patients operated in the eightyear period (2007- 2014) was made according to the frequency and type of thyroid cancer, as well as age and gender of the patients. χ2 test was used for statistical with p<0. Read More

    Implications of oncocytic change in papillary thyroid cancer.
    Clin Endocrinol (Oxf) 2016 Nov 1;85(5):797-804. Epub 2016 Jul 1.
    Research Centre for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon, Korea.
    Objective: Although the presence of oncocytic change in less than 75% of a tumour is not considered to indicate oncocytic variants of papillary thyroid carcinoma (PTC), we frequently observe partial oncocytic change, especially in obese PTC patients. Thus, we sought to investigate the relationship between the presence of oncocytic change of PTC and its prognosis.

    Design, Setting And Participants: We retrospectively studied 142 patients with PTC who had undergone surgery between 2000 and 2005, and re-evaluated their PTC slides to record the proportion of oncocytic change in 10% increments from 0% to 100%. Read More

    Radioactive Iodine Treatment Is Associated with Improved Survival for Patients with Hürthle Cell Carcinoma.
    Thyroid 2016 Jul 6;26(7):959-64. Epub 2016 Jun 6.
    Duke Cancer Institute and Duke Clinical Research Institute, Duke University Medical Center , Durham, North Carolina.
    Background: Hürthle cell carcinoma (HCC) is not typically iodine avid, raising questions regarding postoperative use of radioactive iodine (RAI). The aims of this study were to describe current practice patterns regarding the use of RAI for HCC and to assess its association with survival.

    Methods: The National Cancer Data Base 1998-2006 was queried for all patients with HCC who underwent total thyroidectomy. Read More

    1 OF 21