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    1064 results match your criteria Hurthle Cell Carcinoma

    1 OF 22

    Comparison of clinical characteristics of patients with follicular thyroid carcinoma and Hürthle cell carcinoma.
    Endocrinol Diabetes Nutr 2018 Mar 9;65(3):136-142. Epub 2018 Feb 9.
    Facultad de Ciencias de la Salud, Universidad Pública de Navarra, Pamplona, Navarra, España.
    Introduction: Hürthle cell carcinoma (HCC) is an uncommon thyroid cancer historically considered to be a variant of follicular thyroid carcinoma (FTC). The aim of this study was to assess the differences between these groups in terms of clinical factors and prognoses.

    Patients And Methods: A total of 230 patients (153 with FTC and 77 with HCC) with a median follow-up of 13. Read More

    Preoperative Cytologic Diagnosis of Warthin-like Tumor Variant of Papillary Thyroid Carcinoma.
    J Pathol Transl Med 2018 Feb 12. Epub 2018 Feb 12.
    Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Background: Warthin-like variant of papillary thyroid carcinoma (WLV-PTC) is a relatively rare variant of papillary thyroid carcinoma with favorable prognosis. However, preoperative diagnosis using fine-needle aspiration (FNA) specimens is challenging especially with lymphocytic thyroiditis characterized by Hürthle cells and lymphocytic background. To determine a helpful cytological differential point, we compared WLV-PTC FNA findings with conventional papillary thyroid carcinoma with lymphocytic thyroiditis (PTC-LT) and conventional papillary thyroid carcinoma without lymphocytic thyroiditis (PTC) regarding infiltrating inflammatory cells and their distribution. Read More

    HMGA2 Gene Expression in Fine-needle Aspiration Samples of Thyroid Nodules as a Marker for Preoperative Diagnosis of Thyroid Cancer.
    Appl Immunohistochem Mol Morphol 2018 Feb 5. Epub 2018 Feb 5.
    Department of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
    There is a great interest in molecular markers that would help in the preoperative diagnosis of malignant thyroid nodules in cases of indeterminate fine-needle aspiration cytology. The aim of this study was to determine the diagnostic accuracy of HMGA2 gene expression in discriminating benign from malignant thyroid nodules. In this study, 237 preoperative thyroid fine-needle aspiration samples were analyzed prospectively for the expression of the HMGA2 gene by real-time reverse transcription polymerase chain reaction. Read More

    Pioglitazone Therapy of PAX8-PPARγ Fusion Protein Thyroid Carcinoma.
    J Clin Endocrinol Metab 2018 Jan 24. Epub 2018 Jan 24.
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
    Context: A subset of thyroid carcinomas expresses an oncogenic PAX8-PPARγ fusion protein (PPFP). The PPARγ/PPFP ligand pioglitazone is highly therapeutic in a transgenic mouse model of PPFP thyroid carcinoma, but whether pioglitazone is therapeutic in patients with PPFP thyroid carcinoma is unknown.

    Case Description: Tumor blocks from forty patients with progressive thyroid cancer despite standard of care therapy were screened for PPFP, and the tumor from only one patient (2. Read More

    Propensity score matching analysis of the prognosis for the rare oxyphilic subtype of thyroid cancer (Hurthle cell carcinoma).
    Oncotarget 2017 Nov 8;8(60):101362-101371. Epub 2017 Sep 8.
    Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.
    There is controversy regarding the prognosis of patients with oxyphilic thyroid cancer (OXTC). The present study compared the prognoses of OXTC, papillary thyroid cancer (PTC), and follicular thyroid cancer (FTC), in order to provide a new perspective regarding the treatment guidelines for these diseases. We evaluated data from patients with thyroid cancer who were included in the Surveillance, Epidemiology, and End Results database between 2004 and 2013. Read More

    Hemithyroidectomy for low-risk follicular carcinoma of thyroid: results from a regional hospital.
    Singapore Med J 2017 Dec 7. Epub 2017 Dec 7.
    Department of Surgery, United Christian Hospital, Kowloon, Hong Kong.
    Introduction: Excellent outcome after conservative thyroid surgery for low-risk follicular thyroid carcinoma (FTC) has been reported from highly specialised centres. However, it is uncertain whether similar treatment results can be achieved in low-volume hospitals.

    Methods: At our institution, 49 patients with FTC were treated during 1991-2014. Read More

    Cancer Risk Associated with Nuclear Atypia in Cytologically Indeterminate Thyroid Nodules: A Systematic Review and Meta-Analysis.
    Thyroid 2018 Feb 21;28(2):210-219. Epub 2017 Dec 21.
    1 Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute , Tampa, Florida.
    Background: Indeterminate categories of thyroid cytopathology (categories B-III and B-IV of the Bethesda system) are integrated by a heterogeneous spectrum of cytological scenarios that are generally clustered for analysis and management recommendations. It has been suggested that aspirates exhibiting nuclear atypia have a higher risk of malignancy. This study aimed to assess whether cytologically indeterminate thyroid nodules with nuclear atypia have a significantly higher cancer risk than those without nuclear atypia. Read More

    Follicular thyroid cancer and Hürthle cell carcinoma: challenges in diagnosis, treatment, and clinical management.
    Lancet Diabetes Endocrinol 2017 Oct 25. Epub 2017 Oct 25.
    Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address:
    Follicular thyroid cancer is the second most common differentiated thyroid cancer histological type and has been overshadowed by its more common counterpart-papillary thyroid cancer-despite its unique biological behaviour and less favourable outcomes. In this Review, we comprehensively review the literature on follicular thyroid cancer to provide an evidence-based guide to the management of these tumours, to highlight the lack of evidence behind guideline recommendations, and to identify changes and challenges over the past decades in diagnosis, prognosis, and treatment. We highlight that correct identification of cancer in indeterminate cytological samples is challenging and ultrasonographic features can be misleading. Read More

    F-fluorodeoxyglycose-avid thyroid incidentalomas: the importance of contextual interpretation.
    J Nucl Med 2017 Oct 12. Epub 2017 Oct 12.
    Peter MacCallum Cancer Centre, Australia.
    FDG-avid thyroid incidentalomas (TI) are seen in approximately 2.5% of patients imaged for staging or response assessment of malignancy and represent thyroid cancer in approximately 35% of cases. Consequently, the 2015 ATA guidelines strongly recommend investigation of all FDG-avid nodules ≥1cm with US and fine needle aspiration cytology (FNA). Read More

    EIF1AX Mutation in a Patient with Hürthle Cell Carcinoma.
    Endocr Pathol 2018 Mar;29(1):27-29
    Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, 925 Chestnut Street 6th Floor, Philadelphia, PA, 19107, USA.
    The EIF1AX gene is a novel cancer gene that has been reported in the tumorigenesis of papillary thyroid carcinoma, follicular variant papillary thyroid carcinoma, and anaplastic thyroid carcinoma. A 71-year-old woman presented with a right thyroid mass, which was follicular neoplasm on cytology. The fine needle aspirate of the nodule was examined by next-generation sequencing and found to harbor EIF1AX and TP53 mutations. Read More

    Mitochondrial DNA "common deletion" in post-fine needle aspiration infarcted oncocytic thyroid tumors.
    Hum Pathol 2017 11 27;69:23-30. Epub 2017 Sep 27.
    Department of Oncology, University of Torino, Città della Salute e della Scienza Hospital, 10126 Torino, Italy.
    Thyroid fine needle aspiration (FNA) can rarely induce morphological changes potentially hindering the histopathological diagnosis, especially in Hurthle cell tumors (HCTs), which may easily undergo post-FNA infarction or necrosis. HCTs contain mitochondrion (mt)-rich cells that may bear mtDNA mutations, the most frequent being the so-called common deletion (CD). The aim of this study was to determine the presence and extent of the mtDNA CD in a series of thyroid HCTs that underwent extensive infarction following FNA procedure in comparison with a control series of HCTs lacking post-FNA ischemic/hemorrhagic alterations. Read More

    Ultrasonic diagnosis for thyroid Hürthle cell tumor.
    Cancer Biomark 2017 Sep;20(3):235-240
    Department of Ultrasound, Peking University First Hospital, Beijing 100034, China.
    Objective: This study aims to evaluate the diagnostic value of ultrasound in thyroid Hürthle cell tumors.

    Methods: A retrospective analysis was carried out on 27 patients with thyroid Hürthle cell tumors, in terms of the size, shape, boundary, echo, aspect ratio, cystic degeneration, calcification, peripheral halo sign and blood supply of the tumor, through surgical pathological validation. Then, these were compared with postoperative pathological results. Read More

    Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors.
    J Clin Endocrinol Metab 2017 Nov;102(11):4089-4099
    Department of Urology, Faculty of Medicine, UNESP, São Paulo State University, Botucatu 18618-970, SP, Brazil.
    Context: Even though the majority of well-differentiated thyroid carcinoma (WDTC) is indolent, a number of cases display an aggressive behavior. Cumulative evidence suggests that the deregulation of DNA methylation has the potential to point out molecular markers associated with worse prognosis.

    Objective: To identify a prognostic epigenetic signature in thyroid cancer. Read More

    S Afr J Surg 2017 Sep;55(3):69
    University of Beira Interior, and Centro Hospitalar Cova da Beira, Hospital da Covilhã, and CICS-UBI Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior.
    Background: Iodine deficiency (ID) still affects over two billion people worldwide (266 million school aged children). Pathology patterns in ID include: increase in thyroid cancer, higher percentages of follicular and anaplastic cancers and inversion of the papillary/follicular thyroid cancer frequency ratio. China succeeded in eliminating ID through legislation introduced in 1987 aimed at availability of iodized salt countrywide and South Africa through legislation introduced in 1995. Read More

    Impact of Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Features on Adequacy Criteria and Risk of Malignancy of Thyroid Fine-Needle Aspiration.
    Am J Clin Pathol 2017 Sep;148(3):259-263
    Department of Pathology, Baptist Hospital, Miami, FL.
    Objectives: The impact of noninvasive follicular thyroid neoplasm with papillary-like features (NIFTP) on nondiagnostic and benign diagnoses is not well characterized.

    Methods: The results of all thyroid fine-needle aspirates (FNAs) performed from 1997 to June 2016 with corresponding resections were reviewed.

    Results: From 12,764 aspirates, there were 8,106 (64%) benign diagnoses with 412 (5%) resections and 1,888 (14. Read More

    Endocr Pract 2017 Oct 17;23(10):1262-1269. Epub 2017 Aug 17.
    Objective: There has been increasing interest in active surveillance of papillary thyroid microcarcinoma. The objective of this study was to characterize the incidence and outcomes of nonoperatively managed differentiated thyroid cancers (DTCs) in California.

    Methods: Biopsy-proven DTCs from the California Cancer Registry were linked to data from the California Office of Statewide Health Planning and Development (2004-2012). Read More

    Oncocytic variant of medullary thyroid carcinoma; a rare tumor with numerous diagnostic mimics by fine needle aspiration.
    Diagn Cytopathol 2017 Dec 12;45(12):1148-1152. Epub 2017 Aug 12.
    Department of Pathology, University of Colorado at Denver and Health Sciences Center, Aurora, CO, 80045.
    Oncocytic variant of medullary thyroid carcinoma is rare form of thyroid carcinoma that is easily misdiagnosed on fine needle aspiration specimens due to it is low incidence and cytomorphologic overlap with other more common Hurtle cell lesions. A correct initial diagnosis by fine needle aspiration is imperative as the clinical treatment for medullary carcinoma differs significantly from the mimickers. We present a case of this rare variant tumor that on initial fine needle aspiration was described as a Hurthle cell lesion and was subsequently correctly classified on the resection specimen. Read More

    Aggressive differentiated thyroid cancer with multiple metastases and NRAS and TERT promoter mutations: A case report.
    Oncol Lett 2017 Aug 16;14(2):2186-2190. Epub 2017 Jun 16.
    Endocrinology Unit, Department of Medical Sciences 'M. Aresu', University of Cagliari and University Hospital of Cagliari, I-09042 Cagliari, Italy.
    Sorafenib, a tyrosine kinase inhibitor, is approved for the treatment of advanced differentiated thyroid carcinoma (DTC). Resistance to sorafenib may appear under treatment and may be associated with increased aggressiveness of the neoplasia. The present study reports the case of a 65-year-old male who underwent total thyroidectomy for a follicular thyroid carcinoma, Hürthle cell variant, in February 2005. Read More

    Size of thyroid carcinoma by histotype and variants: A population-based study in a mildly iodine-deficient area.
    Head Neck 2017 Oct 24;39(10):2095-2103. Epub 2017 Jul 24.
    Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy.
    Background: Data relating the size of thyroid cancer with histological types and variants are scarce.

    Methods: All incident thyroid cancer diagnosed between 2003 and 2012 in a mildly iodine-deficient area were derived from a population-based tumor registry. Undifferentiated/anaplastic thyroid cancer and incidental cases were excluded. Read More

    Phosphorylated Mechanistic Target of Rapamycin (p-mTOR) and Noncoding RNA Expression in Follicular and Hürthle Cell Thyroid Neoplasm.
    Endocr Pathol 2017 Sep;28(3):207-212
    Department of Pathology and Laboratory Medicine, University of Wisconsin, School of Medicine and Public Health, 600 Highland Ave, Box 8550, Madison, WI, 53792, USA.
    Oncocytic (Hürthle cell) and follicular neoplasms are related thyroid tumors with distinct molecular profiles. Diagnostic criteria separating adenomas and carcinomas for these two types of neoplasms are similar, but there may be some differences in the biological behavior of Hürthle cell and follicular carcinomas. Recent studies have shown that noncoding RNAs may have diagnostic and prognostic utility in separating benign and malignant Hürthle cell and follicular neoplasms. Read More

    Evolution of the histologic classification of thyroid neoplasms and its impact on clinical management.
    Eur J Surg Oncol 2018 Mar 18;44(3):338-347. Epub 2017 May 18.
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:
    The vast majority of low grade follicular cell derived thyroid carcinomas follows an indolent clinical course and is associated with very low mortality. Risk stratification using multiple clinical and pathologic characteristics has become the standard of care to guide appropriate management and avoid overtreatment. Over the past few decades, the field of thyroid pathology has witnessed several major changes that significantly impacted upon patients' care. Read More

    Survival and prognostic factors for survival, cancer specific survival and disease free interval in 239 patients with Hurthle cell carcinoma: a single center experience.
    BMC Cancer 2017 05 25;17(1):371. Epub 2017 May 25.
    Center for Endocrine Surgery, Clinical Center of Serbia, Pasterova 2, Belgrade, 11000, Serbia.
    Background: Hurthle cell carcinoma makes up 3 to 5% of all thyroid cancers and is considered to be a true rarity. The aim of our study was to analyze clinical characteristics and survival rates of patients with Hurthle cell carcinoma.

    Methods: Clinical data regarding basic demographic characteristics, tumor grade, type of surgical treatment and vital status were collected. Read More

    PSMA Expression in Multinodular Thyroid Neoplasm on Simultaneous Ga-68-PSMA PET/MRI.
    Indian J Nucl Med 2017 Apr-Jun;32(2):159-161
    Department of Molecular Imaging and Nuclear Medicine, Indraprastha Apollo Hospitals, Sarita Vihar, New Delhi, India.
    PSMA PET is increasingly being used in imaging of recurrent prostate carcinoma. A case with suspected recurrent Prostate carcinoma (PCa), raised PSA (Prostate specific antigen) and suspected spinal metastases was referred for whole body Ga-68-PSMA PET/MRI. The study revealed PSMA avid recurrent prostate mass and extensive osseous metastases. Read More

    Hashimoto's thyroiditis associated with thyroid adenoma with Hürthle cells - case report.
    Rom J Morphol Embryol 2017 ;58(1):241-248
    Department of Endocrinology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;
    Chronic thyroiditis may present a focal lesion, often-palpable abnormality, simulating nodular disease. The number and morphology of the Hürthle cells (HC) vary in the thyroid aspirate. Distinguishing between neoplastic and non-neoplastic HC lesions is difficult when using the fine-needle aspiration cytology (FNAC). Read More

    Issues in Managing Hurthle Cell Carcinoma of Thyroid: A Case Report.
    Cureus 2017 Apr 14;9(4):e1167. Epub 2017 Apr 14.
    Oncology, Kingston General Hospital and Hotel Dieu Hospital, Queens University.
    A 61-year-old woman noticed a right neck lump in October 2001. Fine needle aspiration showed follicular neoplasm, adenoma versus carcinoma. The ultrasound scan showed a solid mass of maximum dimension of 3. Read More

    Metastatic Follicular Thyroid Carcinoma and the Primary Thyroid Gross Examination: Institutional Review of Cases from 1990 to 2015.
    Endocr Pathol 2017 Jun;28(2):177-185
    Pathology Service, WRN219, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
    The diagnosis of follicular-patterned carcinomas, including follicular thyroid carcinoma, oncocytic (Hürthle cell) carcinoma, and the encapsulated follicular variant of papillary thyroid carcinoma, requires evidence of capsular and/or vascular invasion. With minimally invasive carcinomas classified often within less than a millimeter of tissue segregating them from adenomas and non-invasive follicular thyroid neoplasms with papillary-like nuclear features, opinions vary internationally over how much of the capsule to submit in order to deem it well enough represented, considering that even if grossly entirely submitted in microcassettes, without leveling through each tissue block, the capsule is truly never entirely examined microscopically. Here, we retrospectively examine submission practices and outcomes at a single, high-volume institution over a 25-year period. Read More

    Aberrant Intrathyroid Tissue: a Report of Intrathyroid Lymph Node Metastasis and a Review of Literature.
    Indian J Surg 2017 Apr 20;79(2):148-152. Epub 2017 Jan 20.
    Department of Surgery, Waikato Hospital, Hamilton, New Zealand.
    Aberrant histological elements have been infrequently reported to exist within the intact thyroid gland. In addition to distant metastases to the thyroid, a number of ectopic tissue rests and unusual cysts have been described within the thyroid gland. In this article, we report the presence of a true intrathyroid lymph node and describe the first reported case of intrathyroid lymph node metastasis of papillary thyroid cancer. Read More

    Parotid gland involvement as an initial presentation of papillary thyroid carcinoma.
    Int J Oral Maxillofac Surg 2017 Aug 22;46(8):965-967. Epub 2017 Apr 22.
    Department of Pathology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
    Papillary thyroid carcinoma (PTC) is the most differentiated malignant thyroid neoplasm. Local metastases of PTC commonly occur in the regional lymph nodes, while distant metastases are mainly to the lung and bone. The case of a patient with PTC who presented with swelling of the parotid gland and neck, mimicking a primary parotid neoplasm, is presented herein. Read More

    Nodular oncocytic hyperplasia: Can cytomorphology allow for the preoperative diagnosis of a nonneoplastic salivary disease?
    Cancer Cytopathol 2017 Aug 14;125(8):627-634. Epub 2017 Apr 14.
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.
    Background: Nodular oncocytic hyperplasia (oncocytosis) of the salivary glands is a benign process that does not inherently require surgical excision. However, cytologic findings in fine-needle aspiration (FNA) of oncocytosis cases have not been well characterized previously, limiting preoperative identification.

    Methods: All available cases of oncocytosis with corresponding FNA specimens were identified from the pathology archives of 3 academic institutions. Read More

    Improving Access to Image-guided Procedures at an Integrated Rural Critical Access Hospital: Ultrasound-guided Thyroid Biopsy Program.
    Curr Probl Diagn Radiol 2017 Nov - Dec;46(6):419-422. Epub 2017 Feb 16.
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Electronic address:
    Purpose: Critical access hospitals face difficulty providing all services locally and may need to refer patients off-site for additional care. Providing on-site minimally invasive biopsies, may obviate visits to tertiary or quaternary care centers. This study aims to assess feasibility and outcomes of an ultrasound-guided thyroid biopsy program in a critical access hospital. Read More

    Risk of Malignancy and Risk of Neoplasia in the Bethesda Indeterminate Categories: Study on 4,532 Thyroid Fine-Needle Aspirations from a Single Institution in India.
    Acta Cytol 2017 14;61(2):103-110. Epub 2017 Apr 14.
    Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Objectives: To determine the frequency of category 3 (atypia of undetermined significance [AUS]/follicular lesion of undetermined significance [FLUS]), category 4 (follicular neoplasm), and category 5 (suspicious for malignancy) of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), the risk of malignancy (ROM) and the risk of neoplasia (RON) in these categories.

    Study Design: A retrospective 6-year audit of 4,532 thyroid fine-needle aspirations (FNA) reported as per the TBSRTC from a single institution with cytohistological correlation in 335 cases.

    Results: The frequency of categories 3, 4, and 5 was 2. Read More

    Parathyroid Adenomas in Adults and Adolescents. Critical Appraisal and Surgical Strategy in 18 Cases.
    Chirurgia (Bucur) 2017 Jan-Feb;112(1):18-24
    Our study underline scarcity of isolated case reports or small case series of parathyroid adenoma (PA) published in autochthonous medical literature,their variable clinical expression among the "historic" varieties but also the diagnostic difficulties and delays of diagnosis as well consecration of surgery as the golden therapeutic standard of this disorder.

    Patients And Method: Demographic, clinical presentations, laboratory and imaging data, operative findings and procedures together with pathology account and outcome from the case reports of 18 patients with documented PHP were retrospectively analyzed.The male/female ratio was 1/5, with ages ranging from 16 to 58 (mean 46) years. Read More

    Cytological evaluation by fine needle aspiration biopsy of incidental focal increased fluorodeoxyglucose uptake in thyroid on positron emission tomography scan.
    Diagn Cytopathol 2017 Jun 6;45(6):501-506. Epub 2017 Mar 6.
    Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
    Background: With the increased use of whole body fluorodeoxyglucose positron emission tomography (PET) scan for staging/restaging or primary diagnosis of neoplasia, thyroid incidentalomas have become more common. The limited reports of PET-positive thyroid incidentalomas showed incidence of malignancy ranging from 14 to 66%, and there is discrepancy in terms of the diagnostic significance of the standard uptake value (SUV) value.

    Methods: This is a retrospective study of 20 PET incidentalomas which had cytological evaluation from October 2009 to February 2015 at a tertiary care university medical center, M:F = 8:12. Read More

    Diagnostic utility of CK19 and CD56 in the differentiation of thyroid papillary carcinoma from its mimics.
    Pathol Res Pract 2017 May 22;213(5):509-517. Epub 2017 Jan 22.
    Department of Pathology,Ahmed Maher Teaching Hospital, Cairo, Egypt.
    Background: Papillary Thyroid Carcinoma (PTC) is the most common type of malignant thyroid tumors. The main diagnostic clue of PTC is the presence of its characteristic nuclear features. Yet, the focal presence of these features in other thyroid lesions causes a diagnostic dilemma. Read More

    How "suspicious" is that nodule? Review of "suspicious" Afirma gene expression classifier in high risk thyroid nodules.
    Diagn Cytopathol 2017 Apr 11;45(4):308-311. Epub 2017 Feb 11.
    Department of Pathology, Hofstra Northwell Health School of Medicine, Lake Success, New York.
    Background: The Afirma gene expression classifier (GEC) is being increasingly utilized to confirm the benign nature of indeterminate FNA cytology results thus avoiding unnecessary surgical procedures. However the "suspicious" result of the Afirma GEC does not classify these indeterminate nodules further in determining appropriate management. This study investigated the outcome of the thyroid nodules deemed to be "suspicious" by the Afirma GEC in a high risk population. Read More

    Endocr Pract 2017 Apr 17;23(4):442-450. Epub 2017 Jan 17.
    Objective: Increasing emphasis is being placed on appropriateness of care and avoidance of over- and under-treatment. Indeterminate thyroid nodules (ITNs) present a particular risk for this problem because cancer found via diagnostic lobectomy (DL) often requires a completion thyroidectomy (CT). However, initial total thyroidectomy (TT) for benign ITN results in lifelong thyroid hormone replacement. Read More

    Primary Thyroid Carcinoma with Low-Risk Histology and Distant Metastases: Clinicopathologic and Molecular Characteristics.
    Thyroid 2017 05 1;27(5):632-640. Epub 2017 Feb 1.
    1 Department of Pathology, Memorial Sloan-Kettering Cancer Center , New York, New York.
    Background: Distant metastases (DM) are a rare occurrence in well-differentiated thyroid carcinoma. The aim of this study was to analyze the clinical, pathologic, and molecular features of primary thyroid carcinoma with low-risk histology that develop DM.

    Methods: A detailed clinicopathologic review and targeted next-generation sequencing were performed on a cohort of well-differentiated thyroid carcinoma lacking gross extrathyroidal extension, extensive vascular invasion, or significant lymph node metastases but exhibiting DM. Read More

    Analysis of malignancy predictors for oxyphile thyroid tumors.
    J BUON 2016 Nov-Dec;21(6):1496-1500
    Surgical Clinic, Clinical Center "Dr Dragisa Misovic-Dedinje", Belgrade, Serbia.
    Purpose: In contrast to other thyroid carcinomas it is difficult to establish a correct preoperative diagnosis for oxyphile carcinoma of the thyroid. In this study we looked for predictive malignancy factors in order to enable surgeons to choose operative treatment and to perform an adequate operation for each patient with an oxyphile neoplasm of the thyroid.

    Methods: In this retrospective study we have analyzed the medical files of all patients with oxyphile tumors of the thyroid operated between 1999 and 2008 in our institution. Read More

    A rare case of cutaneous oncocytic hidradenoma.
    J Cutan Pathol 2017 Mar 2;44(3):289-291. Epub 2017 Feb 2.
    Departments of Dermatology and Pathology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California.
    Oncocytes are epithelial cells characterized by their abundant eosinophilic and finely granular cytoplasm. Their histologic appearance is due to excessive amounts of cytoplasmic mitochondria. Oncocytes generally occur in the setting of benign neoplasms. Read More

    Thyroid FNAC containing hürthle cells and hürthle-like cells: A study of 128 cases.
    J Cytol 2016 Oct-Dec;33(4):214-219
    Department of Pathology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
    Aim: It is a diagnostic challenge to differentiate benign and malignant cytology in the presence of Hürthle cells. In our previous study, it was determined that in fine needle aspirations (FNA), the malignancy outcome of the Hürthle cells containing group tend to be papillary thyroid carcinoma (PTC) in a higher percentage. The most common misinterpretation is caused by PTC cells with large cytoplasm-like Hürthle cells. Read More

    Most Thyroid Cancers Detected by Sonography Lack Intranodular Vascularity on Color Doppler Imaging: Review of the Literature and Sonographic-Pathologic Correlations for 698 Thyroid Neoplasms.
    J Ultrasound Med 2017 Jan 1;36(1):89-94. Epub 2016 Dec 1.
    Lenox Hill Radiology, New York, New York, USA.
    Objectives: This study investigated the controversy of whether hypervascularity on color Doppler sonography correlates with thyroid malignancy by reviewing the literature and sonographic-pathologic correlation.

    Methods: Over a 20-year period, 698 thyroid nodules had color Doppler and histopathologic data. Intranodular vascularity was graded 0 to 3+, and histopathologic findings were recorded. Read More

    Imaging Surveillance in Patients After a Benign Fine-Needle Aspiration Biopsy of the Thyroid: Associated Cost and Incidence of Subsequent Cancer.
    AJR Am J Roentgenol 2017 Feb 8;208(2):358-361. Epub 2016 Dec 8.
    1 Department of Radiology, Thomas Jefferson University, Philadelphia, PA.
    Objective: The objective of our study was to determine patterns and cost of imaging tumor surveillance in patients after a benign fine-needle aspiration (FNA) biopsy of the thyroid in a large teaching hospital as well as the rate of subsequent cancer detection.

    Materials And Methods: This cohort study was approved by the appropriate institutional review board and complied with HIPAA. All patients who had a benign thyroid FNA biopsy between January 1, 1999, and December 31, 2003, were identified from an institutional pathology database. Read More

    Clinicopathological features of thyroid cancer in the elderly compared to younger counterparts: single-center experience.
    J Endocrinol Invest 2017 May 24;40(5):471-479. Epub 2016 Nov 24.
    Department of Endocrinology and Metabolism, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.
    Purpose: The incidence of thyroid cancer is increased in elderly patients. It tends to be larger and have more aggressive characteristics in these patients. Our aim was to compare features of thyroid carcinoma in geriatric and non-geriatric patients. Read More

    Hürthle cell carcinoma: current perspectives.
    Onco Targets Ther 2016 7;9:6873-6884. Epub 2016 Nov 7.
    Section of Endocrine Surgery, Department of Surgery; Duke Cancer Institute; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
    Hürthle cell carcinoma (HCC) can present either as a minimally invasive or as a widely invasive tumor. HCC generally has a more aggressive clinical behavior compared with the other differentiated thyroid cancers, and it is associated with a higher rate of distant metastases. Minimally invasive HCC demonstrates much less aggressive behavior; lesions <4 cm can be treated with thyroid lobectomy alone, and without radioactive iodine (RAI). Read More

    Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy.
    Oncotarget 2016 Nov;7(48):79117-79130
    Research Center for Endocrine and Metabolic Diseases, Division of Endocrinology, Department of Internal Medicine, Chungnam National University School of Medicine, Jung-gu, Daejeon 35015, Republic of Korea.
    Primary cilia are found in the apical membrane of thyrocytes, where they may play a role in the maintenance of follicular homeostasis. In this study, we examined the distribution of primary cilia in the human thyroid cancer to address the involvement of abnormal ciliogenesis in different thyroid cancers. We examined 92 human thyroid tissues, including nodular hyperplasia, Hashimoto's thyroiditis, follicular tumor, Hürthle cell tumor, and papillary carcinoma to observe the distribution of primary cilia. Read More

    Analytical Performance of a Gene Expression Classifier for Medullary Thyroid Carcinoma.
    Thyroid 2016 11;26(11):1573-1580
    1 Veracyte, Inc. , South San Francisco, California.
    Background: The aim of this study was to demonstrate the analytical validity of an RNA classifier for medullary thyroid carcinoma (MTC).

    Methods: Fresh-frozen tissue specimens were obtained from commercial sources, and MTC diagnoses were confirmed by histopathology review. De-identified patient fine-needle aspiration biopsies (FNABs) and whole blood from normal donors were obtained. Read More

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