Sci Rep 2022 Jun 20;12(1):10373. Epub 2022 Jun 20.
Department of Neurology, Vanderbilt University Medical Center, 1611 21st Avenue South, Suite 1532, Nashville, TN, 37232, USA.
The importance of metal biology in neurodegenerative diseases such as Huntingtin Disease is well documented with evidence of direct interactions between metals such as copper, zinc, iron and manganese and mutant Huntingtin pathobiology. To date, it is unclear whether these interactions are observed in humans, how this impacts other metals, and how mutant Huntington alters homeostatic mechanisms governing levels of copper, zinc, iron and manganese in cerebrospinal fluid and blood in HD patients. Plasma and cerebrospinal fluid from control, pre-manifest, manifest and late manifest HD participants were collected as part of HD-Clarity. Read More