22,119 results match your criteria Huntington Disease Dementia


Characterizing the effect of Poast on Chlorella vulgaris, a non-target organism.

Chemosphere 2018 Dec 8;219:704-712. Epub 2018 Dec 8.

Marshall University Department of Chemistry, One John Marshall Dr., Huntington, WV, 25755, USA. Electronic address:

Herbicides may cause unexpected damage to non-target organisms as it is challenging to predict undesirable biotic interactions. Poast is a widely used herbicide formulation that contains sethoxydim and targets the acetyl-CoA carboxylase of perennial grasses. In this study, Chlorella vulgaris, a unicellular green microalga, was exposed to a 0. Read More

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December 2018

Assessment of groundwater quality and remediation in karst aquifers: A review.

Groundw Sustain Dev 2019 Apr 22;8:104-121. Epub 2018 Oct 22.

Department of Civil and Environmental Engineering, Northeastern University, 360 Huntington Ave, Boston, MA 02115, USA.

Karst aquifers, capable of storing and transmitting large amount of water, are the main source of drinking water in many regions worldwide. Their excessive permeability leads to an enhanced vulnerability to retain and spread the contamination accordingly. From sustainability perspective, the environmental, economic and social impacts of karst contamination on water resources management are gaining more attention. Read More

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An investigation into the durability of glycemic control in patients with type II diabetes initiated on canagliflozin or sitagliptin: A real-world analysis of electronic medical records.

J Diabetes Complications 2018 Oct 31. Epub 2018 Oct 31.

Janssen Scientific Affairs, LLC, 1125 Trenton-Harbourton Road, Titusville, NJ 08560, USA. Electronic address:

Aims: The aims of this study were to assess glycemic control, weight loss, and durability of glycemic control in patients initiated on canagliflozin (CANA) versus sitagliptin (SITA).

Methods: Adults with type II diabetes mellitus initiated on CANA or SITA (index date) were identified from IQVIA™ Real-World Data Electronic Medical Records - US database (03/29/2012-04/30/2016). Inverse probability of treatment weighting accounted for baseline differences between cohorts. Read More

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October 2018

Gender Stereotypes and Preconception Health: Men's and Women's Expectations of Responsibility and Intentions to Engage in Preventive Behaviors.

Matern Child Health J 2018 Dec 14. Epub 2018 Dec 14.

Department of Communication, University of Illinois at Urbana-Champaign, Urbana, USA.

Introduction As mounting evidence underscores the importance of both men and women taking steps before pregnancy to improve reproductive outcomes, public health priorities are shifting toward a more gender-inclusive program of promoting preconception health (PCH). This study examined whether prescriptive gender stereotypes, defined as men's and women's beliefs about PCH behavioral norms each gender should uphold, were positively associated with intentions to engage in behaviors to protect a future child's health. Methods Data came from a June 2017 online survey of 609 U. Read More

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December 2018
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Which patients initiate cognitive processing therapy and prolonged exposure in department of veterans affairs PTSD clinics?

J Anxiety Disord 2018 Nov 20;62:53-60. Epub 2018 Nov 20.

Center for Chronic Disease Outcomes Research, Minneapolis VA Health Care System, One Veterans Drive, Minneapolis, MN 55417, USA; Department of Medicine, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455, USA; Department of Psychiatry, University of Minnesota, 2450 Riverside Ave, Minneapolis, MN 55454, USA; Department of Psychology, University of Minnesota, 75 E River Rd, Minneapolis, MN 55455, USA. Electronic address:

The United States Department of Veterans Affairs (VA) provides Cognitive Processing Therapy (CPT) and Prolonged Exposure therapy (PE) for PTSD at all of its facilities, but little is known about systematic differences between patients who do and do not initiate these treatments. VA administrative data were analyzed for 6,251 veterans receiving psychotherapy over one year in posttraumatic stress disorder (PTSD) specialty clinics at nine VA medical centers. CPT and PE were initiated by 2,173 (35%) patients. Read More

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November 2018
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Microfluidic assembly of hydrogel-based immunogenic tumor spheroids for evaluation of anticancer therapies and biomarker release.

J Control Release 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA. Electronic address:

Diffuse large B cell lymphoma (DLBCL), the most common subtype of Non-Hodgkin lymphoma, exhibits pathologic heterogeneity and a dynamic immunogenic tumor microenvironment (TME). However, the lack of preclinical in vitro models of DLBCL TME hinders optimal therapeutic screening. This study describes the development of an integrated droplet microfluidics-based platform for high-throughput generation of immunogenic DLBCL spheroids. Read More

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December 2018
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Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease.

J Mol Cell Cardiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, United States. Electronic address:

Huntington's disease (HD) is a fatal hereditary neurodegenerative disorder, best known for its clinical triad of progressive motor impairment, cognitive deficits and psychiatric disturbances, is caused by CAG-repeat expansion in exon 1 of Huntingtin (HTT). However, in addition to the neurological disease, mutant HTT (mHTT), which is ubiquitously expressed in all tissues, impairs other organ systems. Not surprisingly, cardiovascular dysautonomia as well as the deterioration of circadian rhythms are among the earliest detectable pathophysiological changes in individuals with HD. Read More

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December 2018
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How to Best Predict Fragility Fractures: An Update and Systematic Review.

Isr Med Assoc J 2018 Dec;20(12):773-779

Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: Because fragility fractures have an enormous impact on the practice of medicine and global health systems, effective screening is imperative. Currently, dual-energy X-ray absorptiometry (DXA), which has limited ability to predict fractures, is being used. We evaluated the current literature for a method that may constitute a better screening method to predict fragility fractures. Read More

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December 2018

DNA damage signatures in peripheral blood cells (PBMC) as biomarkers in prodromal Huntington's disease.

Ann Neurol 2018 Dec 14. Epub 2018 Dec 14.

Department of Biology, University of Naples "Federico II", Naples, Italy.

Easily accessible biomarkers in Huntington disease (HD) are actively searched. We investigated telomere length (TL) and DNA double-strand breaks (histone variant pγ-H2AX) as predictive disease biomarkers in peripheral blood mononuclear cells (PBMC) from 25 pre-manifest, 58 HD patients, with similar CAG expansion in the huntingtin gene (HTT) gene and 44 healthy controls (HC). PBMC from PRE-HD and HD groups showed shorter telomeres (p<0. Read More

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December 2018
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27 years of prenatal diagnosis for Huntington disease in the United Kingdom.

Genet Med 2018 Dec 14. Epub 2018 Dec 14.

School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.

Purpose: There is little long-term, population-based data on uptake of prenatal diagnosis for Huntington disease (HD), a late-onset autosomal dominant neurodegenerative disorder, and the effect of the availability of preimplantation genetic diagnosis (PGD) on families' decisions about conventional prenatal diagnosis is not known. We report trends in prenatal diagnosis and preimplantation diagnosis for HD in the United Kingdom since services commenced.

Methods: Long-term UK-wide prospective case record-based service evaluation in 23 UK Regional Genetic Centres 1988-2015, and four UK PGD centers 2002-2015. Read More

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December 2018
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Proteome Profiled in Polymicrobial Urethral Catheter Biofilms.

Proteomes 2018 Dec 9;6(4). Epub 2018 Dec 9.

J. Craig Venter Institute, 9605 Medical Center Drive, Rockville, MD 20850, USA.

, a Gram-positive anaerobic coccoid rod colonizing the human urinary tract, belongs to the taxonomic class of Actinobacteria. We identified as a cohabitant of urethral catheter biofilms (CB). The CBs also harbored more common uropathogens, such as and , supporting the notion that is adapted to a life style in polymicrobial biofilms. Read More

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December 2018

Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors.

Eur J Med Chem 2018 Nov 19;162:810-824. Epub 2018 Nov 19.

Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL, 60612, USA. Electronic address:

Pregnanolone and allopregnanolone-type ligands exert general anesthetic, anticonvulsant and anxiolytic effects due to their positive modulatory interactions with the GABA receptors in the brain. Binding sites for these neurosteroids have been recently identified at subunit interfaces in the transmembrane domain (TMD) of homomeric β3 GABA receptors using photoaffinity labeling techniques, and in homomeric chimeric receptors containing GABA receptor α subunit TMDs by crystallography. Steroid binding sites have yet to be determined in human, heteromeric, functionally reconstituted, full-length, glycosylated GABA receptors. Read More

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November 2018

A Rare Instance of Simultaneous Infection with Disseminated Nocardia and Pulmonary Aspergillus in a Patient Receiving Treatment with Ibrutinib for Chronic Lymphocytic Leukemia.

Cureus 2018 Oct 8;10(10):e3427. Epub 2018 Oct 8.

Infectious Disease, Joan C. Edwards School of Medicine - Marshall University, Huntington, USA.

Disseminated Nocardia infections are a rare occurrence that typically occur in immunocompromised hosts. Chronic lymphocytic leukemia (CLL) is a hematologic malignancy which makes patients susceptible to infections through various mechanisms. The treatments for CLL also target immunologic pathways which can contribute to infections. Read More

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October 2018

NTRK1 is a positive regulator of YAP oncogenic function.

Oncogene 2018 Dec 12. Epub 2018 Dec 12.

Department of Cancer Genetics & Genomics, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA.

Multiple cancer signalling networks take part in regulatory crosstalks with the Hippo tumour suppressor pathway through the transcriptional cofactor Yes-associated protein (YAP). Nevertheless, how YAP is controlled by pathway crosstalks in tumourigenesis remains poorly understood. Here, we performed a targeted kinase inhibitor screen in human cancer cells to identify novel Hippo pathway regulators. Read More

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December 2018

Middle managers' role in implementing evidence-based practices in healthcare: a systematic review.

Implement Sci 2018 Dec 12;13(1):149. Epub 2018 Dec 12.

Center for Healthcare Organization and Implementation Research (CHOIR), VA Boston Healthcare System, 150 South Huntington Avenue (152M), Jamaica Plain Campus, Building 9, Boston, MA, 02130, USA.

Background: Middle managers are in a unique position to promote the implementation of evidence-based practices (EBPs) in healthcare organizations, yet knowledge of middle managers' role in implementation and determinants (e.g., individual-, organizational-, and system-level factors) which influence their role remains fractured, spanning decades and disciplines. Read More

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December 2018

A Modified Partial Likelihood Score Method for Cox Regression with Covariate Error Under the Internal Validation Design.

Biometrics 2018 Dec 7. Epub 2018 Dec 7.

Department of Biostatistics, Yale School of Public Health and Department of Statistics, Yale University, New Haven, CT 06520, USA.

We develop a new method for covariate error correction in the Cox survival regression model, given a modest sample of internal validation data. Unlike most previous methods for this setting, our method can handle covariate error of arbitrary form. Asymptotic properties of the estimator are derived. Read More

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December 2018
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De-Novo Ligand Design against Mutated Huntington Gene by Ligand-Based Pharmacophore Modeling Approach.

Curr Comput Aided Drug Des 2018 Dec 6. Epub 2018 Dec 6.

Department of Mechanical Engineering (SMME), National University of Science and Technology, Islamabad . Pakistan.

Background: Huntington's disease is characterized by three side effects, including motor disturbances, psychiatric elements, and intellectual weakness. The onset for HD has nonlinear converse associations with the number of repeat sequences of the polyglutamine mutations, so that younger patients have a tendency for longer repeats length. This HD variation is because of a development of a polyglutamine (CAG) repeats in the exon 1 of the Huntingtin protein. Read More

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December 2018

ART Denial: Results of a Home-Based Study to Validate Self-reported Antiretroviral Use in Rural South Africa.

AIDS Behav 2018 Dec 6. Epub 2018 Dec 6.

Department of Global Health and Population, Harvard T. H. Chan School of Public Health, 665 Huntington Ave, Boston, MA, 02115, USA.

There is increasing interest in home based testing and treatment of HIV to expand access to treatment in sub-Saharan Africa. Such programs rely on self-reported HIV history and use of antiretroviral therapy (ART). However, the accuracy of self-reported ART use in community settings is not well described. Read More

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December 2018

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.

Science 2018 12;362(6419)

School of Medicine, University of California, San Diego, 9500 Gilman Drive 0760, La Jolla, CA 92093, USA.

To discover leads for next-generation chemoprotective antimalarial drugs, we tested more than 500,000 compounds for their ability to inhibit liver-stage development of luciferase-expressing spp. parasites (681 compounds showed a half-maximal inhibitory concentration of less than 1 micromolar). Cluster analysis identified potent and previously unreported scaffold families as well as other series previously associated with chemoprophylaxis. Read More

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December 2018

Social Determinants of Health and What Mothers Say They Need and Want After Release From Jail.

Prev Chronic Dis 2018 Dec 6;15:E150. Epub 2018 Dec 6.

College of Population Health, Thomas Jefferson University, Philadelphia, Pennsylvania.

Identifying the biopsychosocial needs of mothers who have been released from jail is critical to understanding the best ways to support their health and stability after release. In May through August 2014, we interviewed 15 mothers who had been released from an urban jail about their reentry experiences, and we analyzed transcripts for themes. Eight domains of community reentry emerged through analysis: behavioral health services, education, employment, housing, material resources, medical care, relationships with children, and social support. Read More

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December 2018

Correction to: "His mind will work better with both of us": a qualitative study on fathers' roles and coparenting of young children in rural Pakistan.

BMC Public Health 2018 Dec 6;18(1):1350. Epub 2018 Dec 6.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, 11th floor, Boston, MA, USA.

After publication of the original article [1], the authors wanted to make an amendment in the Acknowledgments section as Muneera Rasheed requested to be removed. This correction article shows the original and revised version of the "Acknowledgments". The original article was not updated. Read More

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December 2018

Total Knee Arthroplasty in Patients with Familial Patellar Absentia Syndrome: A 40-Year Update: A Case Report.

JBJS Case Connect 2018 Dec 12. Epub 2018 Dec 12.

Department of Orthopaedic Surgery, Northwell Health, Huntington Hospital, Huntington, New York.

Case: Isolated patella absentia is an extremely rare phenomenon, with only a few published cases and even fewer follow-up reports. Nearly 40 years after the initial presentation of 2 brothers with bilateral congenital absence of the patella and the publication of a case report, we report the clinical and radiographic findings of their subsequent tibiofemoral osteoarthritis, which was treated with bilateral total knee arthroplasty.

Conclusion: Understanding the biomechanical complications associated with congenital absence of the patella as it relates to a stable knee is vital; in the case of degenerative changes, total knee arthroplasty appears to provide a long-term solution for these patients. Read More

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December 2018
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Integrated photonic platform for quantum information with continuous variables.

Sci Adv 2018 Dec 7;4(12):eaat9331. Epub 2018 Dec 7.

Centre for Quantum Computation and Communication Technology and Centre for Quantum Dynamics, Griffith University, Brisbane, QLD 4111, Australia.

Integrated quantum photonics provides a scalable platform for the generation, manipulation, and detection of optical quantum states by confining light inside miniaturized waveguide circuits. Here, we show the generation, manipulation, and interferometric stage of homodyne detection of nonclassical light on a single device, a key step toward a fully integrated approach to quantum information with continuous variables. We use a dynamically reconfigurable lithium niobate waveguide network to generate and characterize squeezed vacuum and two-mode entangled states, key resources for several quantum communication and computing protocols. Read More

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December 2018
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High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry.

J Biol Chem 2018 Dec 11. Epub 2018 Dec 11.

Biochemsitry and Biomedical Sciences, McMaster University, Canada.

Huntington's disease (HD) is a neurodegenerative, age-onset disorder caused by a CAG DNA expansion in exon 1 of the HTT gene, resulting in a polyglutamine expansion in the huntingtin protein. Nuclear accumulation of mutant huntingtin is a hallmark of HD, resulting in elevated mutant huntingtin levels in cell nuclei. Huntingtin is normally retained at the endoplasmic reticulum via its N17 amphipathic alpha-helix domain but is released by oxidation of methionine eight during reactive oxygen species (ROS) stress. Read More

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December 2018
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Use of predicted vital status to improve survival analysis of multidrug-resistant tuberculosis cohorts.

BMC Med Res Methodol 2018 Dec 11;18(1):166. Epub 2018 Dec 11.

Department of Health Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, USA.

Background: Multidrug-resistant tuberculosis (MDR-TB) cohorts often lack long-term survival data, and are summarized instead by initial treatment outcomes. When using Cox proportional hazards models to analyze these cohorts, this leads to censoring subjects at the time of the initial treatment outcome, instead of them providing full survival data. This may violate the non-informative censoring assumption of the model and may produce biased effect estimates. Read More

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December 2018

Ultrasound-Guided Vascular Access Is an Important Tool to Prevent Catastrophes: Transinferior Epigastric Artery Cardiac Catheterization.

Case Rep Cardiol 2018 8;2018:2041643. Epub 2018 Nov 8.

Department of Cardiovascular Services, Marshall University Joan C. Edwards School of Medicine, Huntington, WV, USA.

We report a case of cardiac catheterization that was done entirely by accidentally accessing the inferior epigastric artery (IEA) through an unintentional puncture of the U-shaped portion of the inferior epigastric artery. Luckily the patient did not have any trauma to the IEA and was d/c home with no complications. A 48-year-old female with history of hypertension and CAD S/P left circumflex stent many years ago who presented to our facility with persistent crescendo angina for which decision was made to proceed with LHC. Read More

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November 2018

Regulation of histone deacetylase 3 by metal cations and 10-hydroxy-2E-decenoic acid: Possible epigenetic mechanisms of queen-worker bee differentiation.

PLoS One 2018 10;13(12):e0204538. Epub 2018 Dec 10.

Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, United States of America.

Histone deacetylases (HDACs) catalyze the hydrolysis of Ɛ-acetyl-lysine residues of histones. Removal of acetyl groups results in condensation of chromatin structure and repression of gene expression. Human class I, II, and IV HDACs are said to be zinc-dependent in that they require divalent zinc ions to catalyze the deacetylase reaction. Read More

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December 2018

Age- and sex-related changes in cortical and striatal nitric oxide synthase in the Q175 mouse model of Huntington's disease.

Nitric Oxide 2018 Dec 5. Epub 2018 Dec 5.

Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.

In Huntington's disease (HD), corticostriatal and striatopallidal projection neurons preferentially degenerate as a result of mutant huntingtin expression. Pathological deficits in nitric oxide (NO) signaling have also been reported in corticostriatal circuits in HD, however, the impact of age and sex on nitrergic transmission is not well characterized. Thus, we utilized NADPH-diaphorase (NADPH-d) histochemistry and qPCR assays to assess neuronal NO synthase (nNOS) activity/expression in aged male and female Q175 heterozygous mice. Read More

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December 2018
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Clinical and genetic characteristics of late-onset Huntington's disease.

Parkinsonism Relat Disord 2018 Nov 29. Epub 2018 Nov 29.

Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands; GROW Research Institute for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands.

Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive.

Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Read More

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November 2018
1 Read

Comparing stuttering attitudes of preschool through 5th grade children and their parents in a predominately rural Appalachian sample.

J Fluency Disord 2018 Nov 15. Epub 2018 Nov 15.

Department of Communication Disorders, 1 John Marshall Drive, Marshall University, Huntington, WV 25755, United States.

Background: Theories relating to young children's social cognitive maturity and their prevailing social groups play important roles in the acquisition of attitudes. Previous research has shown that preschool and kindergarten children's stuttering attitudes are characterized by stronger negative beliefs and self reactions than those of parents. By contrast, 12 year-old children's stuttering attitudes have been shown to be similar to their parents' attitudes. Read More

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November 2018

Single-Neuron Correlates of Error Monitoring and Post-Error Adjustments in Human Medial Frontal Cortex.

Neuron 2018 Dec 1. Epub 2018 Dec 1.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA; Computation and Neural Systems Program, California Institute of Technology, Pasadena, CA, USA; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address:

Humans can self-monitor errors without explicit feedback, resulting in behavioral adjustments on subsequent trials such as post-error slowing (PES). The error-related negativity (ERN) is a well-established macroscopic scalp EEG correlate of error self-monitoring, but its neural origins and relationship to PES remain unknown. We recorded in the frontal cortex of patients performing a Stroop task and found neurons that track self-monitored errors and error history in dorsal anterior cingulate cortex (dACC) and pre-supplementary motor area (pre-SMA). Read More

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December 2018

Implementation of a research capstone course with expanded flexibility.

Curr Pharm Teach Learn 2019 Jan 2;11(1):81-86. Epub 2018 Oct 2.

Department of Pharmacy and Health Systems Sciences, School of Pharmacy, Mail Stop R218 TF Northeastern University, 360 Huntington Avenue, Boston, MA 02115 United States. Electronic address:

Background And Purpose: A research-focused capstone course was designed to improve flexibility in the way pharmacy students meet the university's capstone requirement. The requirement aims to integrate knowledge, skills, and attitudes from didactic coursework and to apply them in a scholarly way to improve critical and evidence-based thinking, communication skills, and professionalism. This report describes the capstone course and faculty and student perceptions after the first year of implementation. Read More

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January 2019
1 Read

Intestinal mucus is capable of stabilizing supersaturation of poorly water-soluble drugs.

J Control Release 2018 Dec 6. Epub 2018 Dec 6.

Department of Chemical Engineering, Northeastern University, 360 Huntington Avenue, Boston, MA 02110, United States. Electronic address:

The utilization of polymers to stabilize drug supersaturation and enhance oral drug absorption has recently garnered considerable interest. The potential role of intestinal mucus in stabilizing drug supersaturation, however, has not been previously explored. The ability for intestinal mucus to stabilize drug supersaturation and delay drug precipitation is potentially useful in enhancing the absorption of orally dosed compounds from drug delivery systems that generate supersaturation within the gastrointestinal tract (e. Read More

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December 2018

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.

Mol Cell 2018 Dec 1. Epub 2018 Dec 1.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

In Parkinson's disease (PD), α-synuclein (αS) pathologically impacts the brain, a highly lipid-rich organ. We investigated how alterations in αS or lipid/fatty acid homeostasis affect each other. Lipidomic profiling of human αS-expressing yeast revealed increases in oleic acid (OA, 18:1), diglycerides, and triglycerides. Read More

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December 2018

Longer schooling but not better off? A quasi-experimental study of the effect of compulsory schooling on biomarkers in France.

Soc Sci Med 2018 Nov 23;220:379-386. Epub 2018 Nov 23.

Department of Social and Behavioral Sciences, Harvard T H Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA; CUNY Graduate School of Public Health and Health Policy, 205 East 42nd Street, New York, NY, 10017, USA.

Less schooling is associated with increased biological risks for chronic disease, but whether increasing years of schooling through policy interventions reduces these risks remains unclear. We examine the effect of a major education reform introduced in 1959 that raised the minimum school leaving age from 14 to 16 years in France, offering a unique natural experiment. We assess the causal impact of increased schooling duration on 16 biomarkers of cardiovascular, metabolic, organ and immune function in a large cohort of men and women born around 1953. Read More

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November 2018
7 Reads

22 kHz and 55 kHz ultrasonic vocalizations differentially influence neural and behavioral outcomes: Implications for modeling anxiety via auditory stimuli in the rat.

Behav Brain Res 2018 Dec 3;360:134-145. Epub 2018 Dec 3.

Developmental Neuropsychobiology Lab, Department of Psychology, Northeastern University, 360 Huntington Ave NI125, Boston, MA, 02115, United States. Electronic address:

The communicative role of ultrasonic vocalizations (USVs) in rats is well established, with distinct USVs indicative of different affective states. USVs in the 22 kHz range are typically emitted by adult rats when in anxiety- or fear-provoking situations (e.g. Read More

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December 2018
2 Reads

A discontinuous Galerkin model for fluorescence loss in photobleaching of intracellular polyglutamine protein aggregates.

BMC Biophys 2018 29;11. Epub 2018 Nov 29.

Department of Biochemistry and Molecular Biology, Campusvej 55, Odense M, 5230 Denmark.

Background: Intracellular phase separation and aggregation of proteins with extended poly-glutamine (polyQ) stretches are hallmarks of various age-associated neurodegenerative diseases. Progress in our understanding of such processes heavily relies on quantitative fluorescence imaging of suitably tagged proteins. Fluorescence loss in photobleaching (FLIP) is particularly well-suited to study the dynamics of protein aggregation in cellular models of Chorea Huntington and other polyQ diseases, as FLIP gives access to the full spatio-temporal profile of intensity changes in the cell geometry. Read More

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November 2018
5 Reads

Insights into GABAergic system alteration in Huntington's disease.

Open Biol 2018 Dec 5;8(12). Epub 2018 Dec 5.

PhD Program for Translational Medicine, China Medical University and Academia Sinica, Taiwan, Republic of China

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disease that is characterized by a triad of motor, psychiatric and cognitive impairments. There is still no effective therapy to delay or halt the disease progress. The striatum and cortex are two particularly affected brain regions that exhibit dense reciprocal excitatory glutamate and inhibitory gamma-amino butyric acid (GABA) connections. Read More

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December 2018
3 Reads

Pharmacological Interventions for Neonatal Abstinence Syndrome.

J Addict Nurs 2018 Oct/Dec;29(4):231-232

Catherine Butcher, PharmD(c), Marshall University School of Pharmacy, Huntington, West Virginia. Leesa Prunty, PharmD, Home Care Services, University Hospitals Rainbow Babies and Children Hospital, Cleveland, Ohio. Omar Attarabeen, PhD, Charles "C. K." Babcock, PharmD, and Isha Patel, PhD, Department of Pharmacy Practice, Research, & Administration, Marshall University School of Pharmacy, Huntington, West Virginia.

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December 2018
1 Read

Neutropenic enterocolitis in patients with FLT3 mutated acute myeloid leukemia undergoing induction chemotherapy with midostaurin.

Int J Hematol 2018 Dec 3. Epub 2018 Dec 3.

Department of Hematology and Oncology, Marshall University, 1400 Hal Greer Blvd, Huntington, WV, 25701, USA.

Neutropenic enterocolitis mostly affects patients with acute myeloid leukemia (AML) who get treated with intensive chemotherapy which is associated with prolonged neutropenia; its pathogenesis is not well understood and the main factors in this life-threatening condition appear to be neutropenia, mucosal injury and a weakened immune system as a consequence of intensive chemotherapeutic agents. Midostaurin in combination with chemotherapy became the standard of care for FLT3 mutant AML since its approval by the United States Food and Drug Administration (FDA) in April 2017. Anecdotally in our institution, we noticed the common occurrence of neutropenic colitis in three out of three patients who were treated with midostaurin as part of induction chemotherapy for AML. Read More

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December 2018
1 Read

Adipocyte OGT governs diet-induced hyperphagia and obesity.

Nat Commun 2018 11 30;9(1):5103. Epub 2018 Nov 30.

Program in Integrative Cell Signaling and Neurobiology of Metabolism and Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.

Palatable foods (fat and sweet) induce hyperphagia, and facilitate the development of obesity. Whether and how overnutrition increases appetite through the adipose-to-brain axis is unclear. O-linked beta-D-N-acetylglucosamine (O-GlcNAc) transferase (OGT) couples nutrient cues to O-GlcNAcylation of intracellular proteins at serine/threonine residues. Read More

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November 2018
1 Read
10.742 Impact Factor

Application of Artificial Intelligence-based Technology in Cancer Management: A Commentary on the Deployment of Artificial Neural Networks.

Anticancer Res 2018 Dec;38(12):6607-6613

School of Engineering, University of Newcastle upon Tyne, Newcastle upon Tyne, U.K.

Artificial intelligence was recognised many years ago as a potential and powerful tool to predict disease outcome in many clinical situations. The conventional approaches using statistical methods have provided much information, but are subject to limitations imposed by the complexity of medical data. The structures of the important variants of the machine learning system artificial neural networks (ANN) are discussed and emphasis is given to the powerful analytical support that could be provided by ANN for the prediction of cancer progression and prognosis. Read More

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December 2018
2 Reads

Comparison of Geriatric Trauma Outcomes When Admitted to a Medical or Surgical Service After a Fall.

J Surg Res 2019 Jan 14;233:391-396. Epub 2018 Sep 14.

Department of Surgery, Marshall University, Huntington, West Virginia.

Background: Blunt trauma in the geriatric population is fraught with poor outcomes, with injury severity and comorbidities impacting morbidity and mortality.

Methods: We retrospectively reviewed 2172 patients aged ≥65 y who fell, requiring hospital admission between January 2012 and December 2016. There were 403 patients in the surgical arm (SA) and 1769 patients in the medical arm (MA). Read More

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January 2019
1 Read

Treatment of psychiatric disturbances in common hyperkinetic movement disorders.

Expert Rev Neurother 2018 Dec 1. Epub 2018 Dec 1.

b Department of Human Neurosciences , Sapienza University of Rome , Rome.

Introduction: This paper reviews studies that have assessed the treatment of psychiatric disturbances in dystonia, tic disorders, Tourette syndrome, Huntington's disease and essential tremor. Areas covered: We searched for papers in English in Pubmed using the following keywords: blepharospasm, cervical dystonia, arm dystonia, laryngeal dystonia, spasmodic dysphonia, tic disorders, Tourette syndrome, Huntington's chorea, essential tremor, depression, anxiety, obsessive compulsive disorders, attention deficit hyperactivity disorders, psychosis, apathy. Expert commentary: Although psychiatric disturbances are frequent in hyperkinetic movement disorders, few controlled studies have assessed the treatment of psychiatric disturbances in such disorders. Read More

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December 2018
4 Reads

Assessment Scales for Patients with Advanced Huntington's Disease: Comparison of the UHDRS and UHDRS-FAP.

Mov Disord Clin Pract 2018 Sep-Oct;5(5):527-533. Epub 2018 Aug 24.

Department of Neurology Leiden University Medical Center Leiden The Netherlands.

Background: The standard clinical assessment tool in Huntington's disease is the Unified Huntington's Disease Rating Scale (UHDRS). In patients with advanced Huntington's disease ceiling and floor effects of the UHDRS hamper the detection of changes. Therefore, the UHDRS-For Advanced Patients (UHDRS-FAP) has been designed for patients with late-stage Huntington's disease. Read More

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August 2018
1 Read

Comparison and assessment of family- and population-based genotype imputation methods in large pedigrees.

Genome Res 2018 Dec 4. Epub 2018 Dec 4.

Qatar Computing Research Institute, Hamad Bin Khalifa University, Doha, Qatar.

Genotype imputation is widely used in genome-wide association studies to boost variant density, allowing increased power in association testing. Many studies currently include pedigree data due to increasing interest in rare variants coupled with the availability of appropriate analysis tools. The performance of population-based (subjects are unrelated) imputation methods is well established. Read More

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December 2018
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African-American sexual minority adolescents and sexual health disparities: An exploratory cross-sectional study.

J Natl Med Assoc 2018 Dec 1. Epub 2018 Dec 1.

Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University Providence, RI, 02912, USA; Centers for Behavioral and Preventive Medicine, The Miriam Hospital, 164 Summit Avenue, Coro East, Suite 309, Providence, RI, 02903, USA; Department of Behavioral and Social Sciences, Brown University, Providence, RI, 02903, USA.

Purpose: To better understand sexual health disparities among African-American sexual minority adolescents.

Methods: African-American adolescents (N = 1120; mean age = 15.24 years) were recruited from 4 cities (Columbia, SC; Macon, GA; Providence, RI; Syracuse, NY) to a larger trial. Read More

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December 2018
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