Neurobiol Dis 2021 Apr 30;155:105374. Epub 2021 Apr 30.
Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Protein Metabolism and Neuroscience Dementia Medical Research Center, College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Neuroscience and dementia Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:
Background: Huntington's disease (HD) starts its pathology long before clinical manifestation, however, there is no therapy to cure it completely and only a few studies have been reported for delaying the progression of HD. Recently, it has been shown that heterochronic parabiosis can modulate the neurodegenerative diseases. Despite the importance of the transportation process of positive factors during heterochronic parabiosis, there were limited understandings because the transportation process is nanoscale, which makes it difficult to identify the messenger unit. Read More