18,208,778 results match your criteria Human reproduction Oxford England[Journal]

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[Application of stretched exponential diffusion-weighted imaging model in quantitative diagnosis of nonalcoholic fatty liver disease: in a rabbit model].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):500-504

Department of Radiology, Northern Jiangsu People's Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, China.

To evaluate the feasibility of diffusion parameters obtained from mono-exponential and stretched exponential diffusion-weighted imaging models in staging of nonalcoholic fatty liver disease and compare the diagnosis ability of nonalcoholic steatohepatitis. Thirty-two 12 -week-old male New Zealand rabbits, about 2.5 kg of each, were randomly divided into five groups. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.005DOI Listing
February 2019

[Establishment of rat model of cardiorenal syndrome by transabdominal subtotal nephrectomy].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):447-452

Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.

To evaluate the changes of rat renal function and cardiac function after transabdominal subtotal nephrectomy (STNx) and provide an ideal animal model for the study of chronic kidney disease (CKD) and cardiorenal syndrome (CRS). The SD rats (male, 5-6 weeks) were randomly divided into Sham group (10) and STNx group (10). The rats from Sham group underwent sham surgery, and the right nephrectomy plus the 2/3 left kidney artery ligation through abdominal incision were performed in the rats from STNx group. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.013DOI Listing
February 2019

[Changes of intestinal mucosal barrier function and effects of early enteral nutrition in patients with severe organophosphorus poisoning].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):442-446

Intensive Care Unit, Bozhou People's Hospital Affiliated to Anhui University of Science and Technology, Bozhou 236800, China.

To observe the changes of intestinal barrier function in patients with acute severe organophosphorus pesticide poisoning (ASOPP) and the effect of early enteral nutrition on them. A single-center, single-sample, prospective, randomized controlled clinical trial was conducted. A total of 50 patients with ASOPP were divided into 24 h enteral nutrition group (group A) and 48 h (48-72 h) enteral nutrition group (B group) according to the order of hospitalization. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.012DOI Listing
February 2019

An International Summit in Human Genetics and Genomics: Empowering clinical practice and research in developing countries.

Mol Genet Genomic Med 2019 Jan;7(1):e00599

National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.

To help fill the knowledge gap in human genetics and genomics, an International Summit (IS) in Human Genetics and Genomics was conceived and organized by the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) as a 5-year initiative, from 2016 to 2020. In its first 3 years, 71 professionals from 34 countries received training. Read More

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http://dx.doi.org/10.1002/mgg3.599DOI Listing
January 2019

Legal and ethical implications of defining an optimum means of achieving unconsciousness in assisted dying.

Anaesthesia 2019 Feb 20. Epub 2019 Feb 20.

Nuffield Department of Anaesthetics, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

A decision by a society to sanction assisted dying in any form should logically go hand-in-hand with defining the acceptable method(s). Assisted dying is legal in several countries and we have reviewed the methods commonly used, contrasting these with an analysis of capital punishment in the USA. We expected that, since a common humane aim is to achieve unconsciousness at the point of death, which then occurs rapidly without pain or distress, there might be a single technique being used. Read More

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http://dx.doi.org/10.1111/anae.14532DOI Listing
February 2019

Effectiveness of Insulin Analogs Compared with Human Insulins in Pregnant Women with Diabetes Mellitus: Systematic Review and Meta-analysis.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):104-115. Epub 2019 Feb 20.

Universidade Federal de Alagoas, Maceió, AL, Brazil.

Diabetes during pregnancy has been linked to unfavorable maternal-fetal outcomes. Human insulins are the first drug of choice because of the proven safety in their use. However, there are still questions about the use of insulin analogs during pregnancy. Read More

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http://dx.doi.org/10.1055/s-0038-1676510DOI Listing
February 2019

Varicella Zoster Virus Induces Differential Cell-Type Specific Responses in Human Corneal Epithelial Cells and Keratocytes.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):704-711

Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, United States.

Purpose: While VZV DNA and antigen have been detected in acute and chronic VZV keratitis, it is unclear whether productive infection of corneal cells is ongoing or whether residual, noninfectious VZV antigens elicit inflammation. Herein, we examined VZV-infected primary human corneal epithelial cells (HCECs) and keratocytes (HKs) to elucidate the pathogenesis of VZV keratitis.

Methods: HCECs and HKs were mock- or VZV infected. Read More

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http://dx.doi.org/10.1167/iovs.18-25801DOI Listing
February 2019

KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):731-740

Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.

Purpose: Krüppel-like factor 4 (KLF4) promotes corneal epithelial (CE) cell fate while suppressing mesenchymal properties. TGF-β plays a crucial role in cell differentiation and development, and if dysregulated, it induces epithelial-mesenchymal transition (EMT). As KLF4 and TGF-β regulate each other in a context-dependent manner, we evaluated the role of the crosstalk between KLF4 and TGF-β-signaling in CE homeostasis. Read More

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http://dx.doi.org/10.1167/iovs.18-26423DOI Listing
February 2019

Circular RNA biogenesis is decreased in postmortem cortical gray matter in schizophrenia and may alter the bioavailability of associated miRNA.

Neuropsychopharmacology 2019 Feb 20. Epub 2019 Feb 20.

School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, 2308, Australia.

Circular RNAs (circRNAs) are a covalently closed subclass of lncRNA molecules formed by back splicing of linear precursor RNA. These molecules are relatively stable and particularly abundant in the mammalian brain and therefore may participate in neural development and function. With the emergence of circRNAs activity in gene regulation, these molecules have been implicated in several biological processes, including synaptic plasticity, and we therefore suspect they may have a role in neurobehavioral disorders. Read More

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http://dx.doi.org/10.1038/s41386-019-0348-1DOI Listing
February 2019

A simple layer-stacking technique to generate biomolecular and mechanical gradients in photocrosslinkable hydrogels.

Biofabrication 2019 Feb 20. Epub 2019 Feb 20.

Center for Minimally Invasive Therapeutics, UCLA, Los Angeles, California, UNITED STATES.

Physicochemical and biological gradients are desirable features for hydrogels to enhance their relevance to biological environments for three-dimensional (3D) cell culture. Therefore, simple and efficient techniques to generate chemical, physical and biological gradients within hydrogels are highly desirable. This work demonstrates a technique to generate biomolecular and mechanical gradients in photocrosslinkable hydrogels by stacking and crosslinking prehydrogel solution in a layer by layer manner. Read More

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http://dx.doi.org/10.1088/1758-5090/ab08b5DOI Listing
February 2019

Cholinergic drugs ameliorate endothelial dysfunction by decreasing O-GlcNAcylation via M3 AChR-AMPK-ER stress signaling.

Life Sci 2019 Feb 17. Epub 2019 Feb 17.

Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, People's Republic of China. Electronic address:

Aims: Obesity is associated with increased cardiovascular morbidity and mortality. It is accompanied by augmented O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins via increasing hexosamine biosynthetic pathway (HBP) flux. However, the changes and regulation of the O-GlcNAc levels induced by obesity are unclear. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.036DOI Listing
February 2019

An industry perspective: a streamlined screening strategy using alternative models for chemical assessment of developmental neurotoxicity.

Neurotoxicology 2019 Feb 17. Epub 2019 Feb 17.

Toxicology & Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan. Electronic address:

Developmental neurotoxicity (DNT) is an important endpoint for the safety assessment of chemicals. However, the current in vivo animal model for DNT assessment is resource-intensive and may not fully capture all mechanisms that may be relevant to DNT in humans. As a result, there is a growing need for more reliable, time- and cost-efficient approaches for DNT evaluation. Read More

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http://dx.doi.org/10.1016/j.neuro.2019.02.010DOI Listing
February 2019

Using A Developmental Ecology Framework to Align Fear Neurobiology Across Species.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychology, Columbia University, New York, NY 10027, USA; email: , , ,

Children's development is largely dependent on caregiving; when caregiving is disrupted, children are at increased risk for numerous poor outcomes, in particular psychopathology. Therefore, determining how caregivers regulate children's affective neurobiology is essential for understanding psychopathology etiology and prevention. Much of the research on affective functioning uses fear learning to map maturation trajectories, with both rodent and human studies contributing knowledge. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095727DOI Listing
February 2019

History of Psychopharmacology.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California 90095-1759, USA; email:

We live in an age of psychopharmacology. One in six persons currently takes a psychotropic drug. These drugs have profoundly shaped our scientific and cultural understanding of psychiatric disease. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095514DOI Listing
February 2019

International Divergence in Gene Patenting.

Annu Rev Genomics Hum Genet 2019 Feb 20. Epub 2019 Feb 20.

Centre for IT and IP Law, KU Leuven, 3000 Leuven, Belgium.

This review explores the recent divergence in international patent law relating to the patenting of genes and related subject matter. This divergence stems primarily from decisions of the highest courts in the United States and Australia on the eligibility of patent claims relating to the BRCA gene sequences. Patent offices, courts, and policy makers have struggled for many years to clearly articulate the bounds of patent claims on isolated and synthetic DNA and related products and processes, including methods for their use in genetic diagnostics. Read More

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http://dx.doi.org/10.1146/annurev-genom-083118-015112DOI Listing
February 2019

Kratom exposures reported to United States poison control centers: 2011-2017.

Clin Toxicol (Phila) 2019 Feb 20:1-8. Epub 2019 Feb 20.

a Center for Injury Research and Policy , The Research Institute at Nationwide Children's Hospital , Columbus , OH , USA.

Context: Kratom, or Mitragyna speciosa, is a plant indigenous to Southeast Asia that has gained national attention in the United States for its increased use in the self-management of opioid withdrawal and pain, as well as for concerns about its safety.

Methods: This study analyzes exposures to kratom reported to poison control centers (PCCs) in the United States during 2011-2017 from the National Poison Data System (NPDS).

Discussion: From 2011 through 2017, 1807 kratom exposures were reported to United States PCCs. Read More

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http://dx.doi.org/10.1080/15563650.2019.1569236DOI Listing
February 2019

High Throughput Complementary Analysis and Quantitation of Metabolites by MALDI- and Silicon Nanopost Array-Laser Desorption Ionization Mass Spectrometry.

Anal Chem 2019 Feb 20. Epub 2019 Feb 20.

Silicon nanopost arrays (NAPA) have been shown to be effective substrates for laser desorption ionization-mass spectrometry (LDI-MS), and have been used to analyze a variety of samples including peptides, metabolites, drugs, explosives, and intact cells, as well as to image lipids and metabolites in tissue sections. However, no direct comparison has yet been conducted between NAPA-MS and the most commonly-used LDI-MS technique, matrix-assisted laser desorption ionization (MALDI)-MS. In this work, we compare the utility of NAPA-MS to that of MALDI-MS using two common matrices for the analysis of metabolites in cellular extracts and human urine. Read More

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http://dx.doi.org/10.1021/acs.analchem.8b05074DOI Listing
February 2019

Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer.

N Engl J Med 2019 Feb;380(8):741-751

From the Massachusetts General Hospital Cancer Center (A.B., S.J.I.) and Dana-Farber Cancer Institute (S.M.T.), Harvard Medical School, Boston; Vanderbilt-Ingram Cancer Center, Nashville (I.A.M., V.G.A.); Weill Cornell Medical College (L.T.V.) and New York-Presbyterian-Columbia University Irving Medical Center (K.K.), New York; University of Colorado Cancer Center, Aurora (J.R.D.); Texas Oncology, Baylor University Medical Center, US Oncology, Dallas (J.O.); Orlando Health University of Florida Health Cancer Center, Orlando (R.L.M., N.C.S.); Yale University School of Medicine, New Haven, CT (A.D.S.); University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco (H.S.R.); Immunomedics, Morris Plains, NJ (D.M.G., R.I., S.W., R.M.S., W.A.W.); and AIS Consulting, Ann Arbor, MI (A.M.S.).

Background: Standard chemotherapy is associated with low response rates and short progression-free survival among patients with pretreated metastatic triple-negative breast cancer. Sacituzumab govitecan-hziy is an antibody-drug conjugate that combines a humanized monoclonal antibody, which targets the human trophoblast cell-surface antigen 2 (Trop-2), with SN-38, which is conjugated to the antibody by a cleavable linker. Sacituzumab govitecan-hziy enables delivery of high concentrations of SN-38 to tumors. Read More

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http://dx.doi.org/10.1056/NEJMoa1814213DOI Listing
February 2019

Design of CK2β-mimicking peptides as tools to study the CK2α/CK2β interaction in cancer cells.

ChemMedChem 2019 Feb 20. Epub 2019 Feb 20.

University of Cologne, Department of Pharmacology, Gleueler Strasse 24, 50931, Cologne, GERMANY.

The ubiquitously expressed Ser/Thr kinase CK2 is a key regulator in a variety of key processes in normal and malignant cells. Due to its distinctive anti-apoptotic and tumor-driving properties, elevated levels of CK2 have frequently been found in tumors of different origin. In recent years, development of CK2 inhibitors has largely been focused on ATP-competitive compounds; however, targeting the CK2α/CK2β interface has emerged as a further concept that might avoid selectivity issues. Read More

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http://dx.doi.org/10.1002/cmdc.201800786DOI Listing
February 2019

Gods associated with male fertility and virility.

Andrology 2019 Feb 20. Epub 2019 Feb 20.

Departamento de Cirurgia, Universidade Federal de Pernambuco, Recife, Brazil.

Background: Human fertility has always been a topic of curiosity and devotion. Many cultures consider fertility to be a necessity for the survival and perpetuation of mankind and since early times, myths were created to explain this fabulous process. Fertility gods were ubiquitous in numerous ancient human cultures and were used both to understand fertility and to cope with infertility by means of rituals and offerings. Read More

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http://dx.doi.org/10.1111/andr.12599DOI Listing
February 2019

Drug Discovery for Pemphigoid Diseases.

Curr Protoc Pharmacol 2019 Feb 20:e55. Epub 2019 Feb 20.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Pemphigoid diseases (PDs) are a group of autoimmune bullous diseases characterized and caused by autoantibodies targeting structural proteins of the skin and mucous membranes. Chronic inflammation, subepidermal blistering, and often scaring are the clinical characteristics of PDs. Itching and, in severe cases, disabilities resulting from scaring (i. Read More

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http://dx.doi.org/10.1002/cpph.55DOI Listing
February 2019

An explicit microFE approach to investigate the post-yield behaviour of trabecular bone under large deformations.

Int J Numer Method Biomed Eng 2019 Feb 20:e3188. Epub 2019 Feb 20.

Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstr. 78, Bern, CH-3014, Switzerland.

Homogenised finite element (FE) analyses are able to predict osteoporosis-related bone fractures and become useful for clinical applications. The predictions of FE analyses depend on the apparent, heterogeneous, anisotropic, elastic and yield material properties, which are typically determined by implicit μFE analyses of trabecular bone. The objective of this study is to explore an explicit μFE approach to determine the apparent post-yield behaviour of trabecular bone, beyond the elastic and yield properties. Read More

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http://dx.doi.org/10.1002/cnm.3188DOI Listing
February 2019

Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full-Thickness Skin Regeneration During Wound Healing.

Small 2019 Feb 20:e1900046. Epub 2019 Feb 20.

Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China.

Developing injectable nanocomposite conductive hydrogel dressings with multifunctions including adhesiveness, antibacterial, and radical scavenging ability and good mechanical property to enhance full-thickness skin wound regeneration is highly desirable in clinical application. Herein, a series of adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid-graft-dopamine and reduced graphene oxide (rGO) using a H O /HPR (horseradish peroxidase) system are prepared for wound dressing. These hydrogels exhibit high swelling, degradability, tunable rheological property, and similar or superior mechanical properties to human skin. Read More

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http://dx.doi.org/10.1002/smll.201900046DOI Listing
February 2019

Validation of an MPC Polymer Coating to Attenuate Surface-Induced Crosstalk between the Complement and Coagulation Systems in Whole Blood in In Vitro and In Vivo Models.

Macromol Biosci 2019 Feb 20:e1800485. Epub 2019 Feb 20.

Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjölds väg 20, SE-751 85, Uppsala, Sweden.

Artificial surfaces that come into contact with blood induce an immediate activation of the cascade systems of the blood, leading to a thrombotic and/or inflammatory response that can eventually cause damage to the biomaterial or the patient, or to both. Heparin coating has been used to improve hemocompatibility, and another approach is 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymer coatings. Here, the aim is to evaluate the hemocompatibility of MPC polymer coating by studying the interactions with coagulation and complement systems using human blood in vitro model and pig in vivo model. Read More

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http://dx.doi.org/10.1002/mabi.201800485DOI Listing
February 2019

Exploring the behavioral and cognitive phenotype of KBG syndrome.

Genes Brain Behav 2019 Feb 20:e12553. Epub 2019 Feb 20.

Centre of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands.

KBG syndrome is a neurodevelopmental disorder, caused by dominant mutations in ANKRD11, that is characterized by developmental delay/intellectual disability, mild craniofacial dysmorphisms, and short stature. Behavior and cognition have hardly been studied, but anecdotal evidence suggests higher frequencies of ADHD-symptoms and social-emotional impairments. In this study, behavioral and cognitive profile of KBG syndrome will be investigated in order to examine if and how cognitive deficits contribute to behavioral difficulties. Read More

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http://dx.doi.org/10.1111/gbb.12553DOI Listing
February 2019

Genetic association of DNMT variants can play a critical role in defining the methylation patterns in autism.

IUBMB Life 2019 Feb 20. Epub 2019 Feb 20.

Human Molecular Genetics Laboratory, Rajiv Gandhi Centre for Biotechnology, Trivandrum, Kerala, India.

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with impairments in social communication, restricted, repetitive and stereotyped behaviors. Both genetic and environmental factors are known to contribute toward pathophysiology of Autism. Environmental influences on gene expression can be mediated by methylation patterns which are established and maintained by DNA methyltransferases. Read More

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http://dx.doi.org/10.1002/iub.2021DOI Listing
February 2019

Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts.

BJOG 2019 Feb 20. Epub 2019 Feb 20.

The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

Objective: To assess the separate and combined associations of maternal pre-pregnancy BMI and gestational weight gain with the risks of pregnancy complications and their population impact.

Design: Individual participant data meta-analysis of 39 cohorts.

Setting: Europe, North America and Oceania. Read More

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http://dx.doi.org/10.1111/1471-0528.15661DOI Listing
February 2019

Evaluation of pulmonary toxicity of benzalkonium chloride and triethylene glycol mixtures using in vitro and in vivo systems.

Environ Toxicol 2019 Feb 20. Epub 2019 Feb 20.

Risk Assessment Division, Environmental Health Research Department, National Institute of Environmental Research, Incheon, Republic of Korea.

Benzalkonium chloride (BAC) is a widely used disinfectant/preservative, and respiratory exposure to this compound has been reported to be highly toxic. Spray-form household products have been known to contain BAC together with triethylene glycol (TEG) in their solutions. The purpose of this study was to estimate the toxicity of BAC and TEG mixtures to pulmonary organs using in vitro and in vivo experiments. Read More

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http://dx.doi.org/10.1002/tox.22722DOI Listing
February 2019

HspBP1 and anti-HspBP1 levels in the serum of HIV-infected individuals are associated to the disease progression.

J Appl Microbiol 2019 Feb 20. Epub 2019 Feb 20.

Laboratory of Cellular and Molecular Immunology - Federal University of Health Sciences of Porto Alegre, Av. Sarmento Leite, 245, Centro Historico, 90050-170, Porto Alegre, RS, Brazil.

Aims: The objective of this research was to quantify the levels of circulating HspBP1 and anti-HspBP1 IgG in HIV-infected individuals and to correlate them with CD4 T cell counts and viral load, as well as to determine the kinetics of those proteins during acute phase.

Methods And Results: Sixty serum samples from HIV-positive outpatients, thirty with high viral load and thirty with low viral load were analyzed. The HspBP1and anti-HspBP1 were quantified by ELISA. Read More

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http://dx.doi.org/10.1111/jam.14230DOI Listing
February 2019

Creating Cell and Animal Models of Human Disease by Genome Editing Using CRISPR/Cas9.

J Gene Med 2019 Feb 20:e3082. Epub 2019 Feb 20.

Department of Genetics, Shiraz University of Medical Science, Shiraz, Iran.

Aims: Set of unique sequences in bacterial genomes, responsible for protecting bacteria against bacteriophages, have been recently used for genetic manipulation of specific points in the genome. These system comprises of one RNA component and one enzyme component, known as CRISPR and Cas9, respectively. The present review focuses on the applications of the CRISPR/Cas9 technology in the development of cellular and animal models of human disease. Read More

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http://dx.doi.org/10.1002/jgm.3082DOI Listing
February 2019

The effect of final irrigation with MTAD, QMix, and EDTA on smear layer removal and mineral content of root canal dentin.

Microsc Res Tech 2019 Feb 20. Epub 2019 Feb 20.

Department of Histology and Embryology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

To compare the smear layer removal ability and mineral content of root canal dentine after initial irrigation with NaOCl and final irrigation with MTAD, QMix, and 17% EDTA. Forty extracted human maxillary incisors before root canal preparation and irrigation with NaOCl were randomly divided into four groups (n = 10) according to the type of final irrigants used: MTAD, QMix, 17% EDTA, and control (sterile distilled water). Scanning electron microscopy (SEM) was used to assess the presence of smear layer. Read More

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http://dx.doi.org/10.1002/jemt.23239DOI Listing
February 2019

Undiagnosed delirium is frequent and difficult to predict: Results from a prevalence survey of a tertiary hospital.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

Department of Medicine and Aged Care, The Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.

Aims And Objectives: To study the prevalence and determinants of undiagnosed delirium in a tertiary hospital.

Background: Delirium is a common inpatient condition. It is frequently undiagnosed in a variety of settings, but determinants of undiagnosed delirium are largely unknown, and the frequency of undiagnosed delirium across all inpatient units is uncertain. Read More

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http://dx.doi.org/10.1111/jocn.14833DOI Listing
February 2019

The use of human and bovine commercial media for oocyte maturation and embryo development in the domestic cat (Felis catus).

Reprod Domest Anim 2019 Feb 20. Epub 2019 Feb 20.

Foundation Municipal Park and the Zoological Garden in Cracow, ul. Kasy Oszczędności Miasta Krakowa 14, 30-232, Kraków.

The aim of this study was to examine the suitability of commercial media designed for humans and cattle for oocyte maturation and embryo culture in the domestic cat. In Exp. I, feline oocytes collected ex vivo were subjected to in vitro maturation in a laboratory-made culture medium (based on M199) or a commercial medium designed for cattle cells (BO-IVM ). Read More

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http://dx.doi.org/10.1111/rda.13418DOI Listing
February 2019

Critical Review of Styrene Genotoxicity Focused on the Mutagenicity/Clastogenicity Literature and Using Current OECD Guidance.

Environ Mol Mutagen 2019 Feb 20. Epub 2019 Feb 20.

Ramboll, 124 West Capitol Avenue, Suite 1605, Little Rock, AR 72201, USA.

Styrene is an important high production volume chemical used to manufacture polymeric products. In 2018, IARC classified styrene as probably carcinogenic to humans; NTP lists styrene as reasonably anticipated to be a human carcinogen. The genotoxicity literature for styrene and its primary metabolite, styrene 7,8-oxide (SO), begins in the 1970s. Read More

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http://dx.doi.org/10.1002/em.22278DOI Listing
February 2019

Evaluation of pay-for-release conservation incentives for unintentionally caught threatened species.

Conserv Biol 2019 Feb 20. Epub 2019 Feb 20.

Biological Sciences, University of Windsor, 401 Sunset Avenue, Windsor, ON, N9B 3P4, Canada.

In the developing world, the exploitation of threatened species jeopardizes their permanence in the wild. Because not all captures are intentional, for instance when capture methods have low selectivity, pressure on these species may be lessened by releasing living incidentally caught animals. However, it is often unrealistic to expect people to voluntarily do so because it means foregoing the benefits of resource extraction. Read More

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http://dx.doi.org/10.1111/cobi.13300DOI Listing
February 2019

Role of ADAM17 as a regulatory checkpoint of CD16A in NK cells and as a potential target for cancer immunotherapy.

J Leukoc Biol 2019 Feb 20. Epub 2019 Feb 20.

Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, USA.

Human NK cell antitumor activities involve Ab-dependent cell-mediated cytotoxicity (ADCC), which is a key mechanism of action for several clinically successful tumor-targeting therapeutic mAbs. Human NK cells exclusively recognize these Abs by the Fcγ receptor CD16A (FcγRIIIA), one of their most potent activating receptors. Unlike other activating receptors on NK cells, CD16A undergoes a rapid down-regulation in expression by a proteolytic process following NK cell activation with various stimuli. Read More

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http://dx.doi.org/10.1002/JLB.2MR1218-501RDOI Listing
February 2019

Riluzole promotes neurological function recovery and inhibits damage extension in rats following spinal cord injury: a meta-analysis and systematic review.

J Neurochem 2019 Feb 20. Epub 2019 Feb 20.

Spine Disease Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

Spinal cord injury (SCI) is a devastating condition that has few treatment options. Riluzole, a sodium channel blocker used to treat amyotrophic lateral sclerosis, has been initially trialed in human SCI. We performed a systematic review to critically assess the efficacy of riluzole in locomotor recovery and damage extension in SCI rat models, and the potential for clinical translation. Read More

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http://dx.doi.org/10.1111/jnc.14686DOI Listing
February 2019

Not only a Hollywood trend: The dermatologic features of villains in classic and contemporary literature.

Br J Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Dermatology Department, University General Hospital of Patras, Greece.

A disproportional number of movie villains have skin dosorders . However, it is not only in Hollywood that this is over-represented, it is seen in other forms of art and human expression, including classic and contemporary literature. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/bjd.17782DOI Listing
February 2019

Human papillomavirus type 8 oncoproteins E6 and E7 cooperate in downregulation of the cellular checkpoint kinase-1.

Int J Cancer 2019 Feb 20. Epub 2019 Feb 20.

Institute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Fürst-Pückler-Str. 56, 50935 Cologne, Germany.

Human papillomavirus 8 (HPV8) is associated with the development of squamous cell carcinomas (SCC) of the skin. HPV-infected keratinocytes are able to over-ride normal checkpoint control mechanisms and sustain cell cycle activity, allowing for synthesis of cellular proteins necessary for viral genome amplification. To study how HPV8 may disrupt cell-cycle control, we analysed the impact of HPV8 early gene expression on one of the key regulators of cell cycle and DNA damage response, checkpoint kinase-1 (CHK1). Read More

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http://dx.doi.org/10.1002/ijc.32223DOI Listing
February 2019

Examining the contribution of surrounding intact skin during cutaneous healing.

J Anat 2019 Feb 20. Epub 2019 Feb 20.

Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada.

Severe cutaneous wounds expose the body to the external environment, which may lead to impairments in bodily functions and increased risk of infection. There is a need to develop skin substitutes which could effectively promote complete skin regeneration following an injury. Murine models are used to test such skin substitutes, but their healing involves contraction of the dermis not found in human wounds. Read More

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http://dx.doi.org/10.1111/joa.12941DOI Listing
February 2019

Thermal Inactivation Kinetics of Tulane Virus in Cell-Culture Medium and Spinach.

J Food Sci 2019 Feb 20. Epub 2019 Feb 20.

Dept. of Food Science, Univ. of Tennessee, 2605 River Drive, Knoxville, TN 37996, U.S.A.

Human noroviruses (HNoVs) cause significant gastrointestinal disease outbreaks worldwide. Tulane virus (TV) is a cultivable HNoV surrogate widely used to determine control measures against HNoVs. The objective of this study was to determine the heat inactivation kinetics (D- and z-values) of TV in cell-culture media and on spiked homogenized spinach using the first-order and Weibull models. Read More

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http://dx.doi.org/10.1111/1750-3841.14461DOI Listing
February 2019

Association of cardiovascular autonomic dysfunction with peripheral arterial stiffness in patients with type 1 diabetes.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Context: Cardiovascular autonomic (CAN) neuropathy appears to contribute to peripheral arterial stiffness (AS) in type 1 diabetes. If CAN in patients with AS is associated to concomitant asymptomatic atherosclerotic disease (aPAD) remains unclear.

Objective: To assess the risk of CAN in patients with type 1 diabetes and AS and its potential association to atherosclerosis. Read More

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http://dx.doi.org/10.1210/jc.2018-02729DOI Listing
February 2019

Adrenal steroids in female hypothyroid neonates: Unraveling an association between thyroid hormones & adrenal remodeling.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Division of Endocrinology, Metabolism and Diabetes, 1st Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Context: The adrenal gland undergoes significant remodeling during the neonatal period, an essential developmental process that still remains incompletely understood. With respect to control over the remodeling process and, specifically, the role of thyroid hormones (TH), no human studies have been published. The effect of both hypo- and hyper-thyroidism has only been evaluated in adults, focusing on the mature adrenal. Read More

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http://dx.doi.org/10.1210/jc.2018-02013DOI Listing
February 2019

DNA Methylation Regulates Corneal Epithelial Wound Healing by Targeting miR-200a and CDKN2B.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):650-660

School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: DNA methylation is a key epigenetic modification involved in various biological processes and diseases. Corneal epithelial wound healing (CEWH) is essential for restoring corneal integrity and transparency after injury. However, the role of DNA methylation in CEWH remains elusive. Read More

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http://dx.doi.org/10.1167/iovs.18-25443DOI Listing
February 2019

[Clinical anthropology: Between the Philosophy of Psychiatry and Human Sciences].

Vertex 2018 Sep;XXIX(141):349-360

Facultad de Psicología, Universidad de Buenos Aires.

The terms "Psycho-logy", "Psycho-patho-logy", "Psychiatry" speaks us, considering Greek etymology, about the Platonic Dualism that distinguishes a rational psyche opposed to a body-jail - tomb of the soul, where a "logic of the separation" will become a "logic of the disjunction", where the "world of ideas" represents the reason while "sensible world" translates the deviation, the madness. Through various oppositions, it shows the need for a globalizing environment that allows joining the social and/or human sciences with the biological sciences. Exactly, the clinical Anthropology constitutes a new disciplinary space that analyzes forms of subjectivation and of the suffering human, in their plurality of dimensions and "directions of sense". Read More

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September 2018

[Sustainable development goals and mental health].

Vertex 2018 Nov;XXIX(142):300-303

Centre for Global Mental Health, King's College London, Institute of Psychiatry.

In 2015, the United Nations Sustainable Development Goals (SDGs) set the course for a more equitable distribution of resources globally. For the first time in history, this collective global commitment explicitly included mental health-related objectives, and manifested them as targets in the health SDG 3. This represents a unique opportunity to increase coverage and quality of services, especially in low- and middle-income countries, in which the current treatment gap surpasses 80% even for the most severe disorders. Read More

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November 2018

[Mental health in general hospitals of the City of Rosario and Great Rosario, Argentina].

Vertex 2018 Nov;XXIX(142):255-262

Facultad de Psicología, Universidad Nacional de Rosario.

Eight years after the enactment of the National Mental Health Law (26.657), we consider it necessary to build spaces for debate on the potentialities and challenges in its practical implementation. This research addresses the mental health practices in the general public hospitals of the city of Rosario and Gran Rosario, Argentina, from the workers' perspective. Read More

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November 2018

Introduction of the YTE mutation into the non-immunogenic HIV bnAb PGT121 induces anti-drug antibodies in macaques.

PLoS One 2019 20;14(2):e0212649. Epub 2019 Feb 20.

PlantVax Corporation, Rockville, Maryland United States of America.

Recombinant antibodies play increasingly important roles as immunotherapeutic treatments for human cancers as well as inflammatory and infectious diseases and have revolutionized their management. In addition, their therapeutic potential may be enhanced by the introduction of defined mutations in the crystallizable fragment (Fc) domains eg YTE (M252Y/S254T/T256E) and LS (M428L/N434S), as a consequence of increased half-lives and prolonged duration of protection. However, the functional properties of any biologic may be compromised by unanticipated immunogenicity in humans, rendering them ineffective. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212649PLOS
February 2019

Supported employment: Meta-analysis and review of randomized controlled trials of individual placement and support.

PLoS One 2019 20;14(2):e0212208. Epub 2019 Feb 20.

Human Flourishing Program, The Institute for Quantitative Social Science, Harvard University, Cambridge, MA, United States of America.

Supported employment is a treatment whereby those with severe mental illness (or other disabilities) receive aid searching for competitive employment and mental health (or other) treatments concurrently. The most popular implementation of supported employment is individual placement and support (IPS). We conducted meta-analytic analyses of the randomized controlled trials of IPS. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212208PLOS
February 2019

A multifactorial approach of nutritional, intellectual, brain development, cardiovascular risk, socio-economic, demographic and educational variables affecting the scholastic achievement in Chilean students: An eight- year follow-up study.

PLoS One 2019 20;14(2):e0212279. Epub 2019 Feb 20.

Laboratory of Nutrition and Neurological Sciences, Human Nutrition Area, Institute of Nutrition and Food Technology Dr. Fernando Monckeberg Barros (INTA), University of Chile, Santiago, Chile.

The aim of this study was to quantitate the relative impact of nutritional, intellectual, brain development, cardiovascular risk, socio-economic, demographic and educational variables on the results of the 2009 Quality Education Measurement System (SIMCE) tests of language and mathematics for scholastic achievement (SA) applying a multifactorial approach, in school-age children of the 2010 5th elementary school grade (5ESG) and of the 1st grade of high school (1HSG). The purposes were: i) to test the hypothesis that intellectual ability, the level of SA of the educational establishments in the 2009 SIMCE tests, sex, parental schooling levels, and head circumference-for-age Z-score are the most relevant parameters associated with 2009 SIMCE outcomes; ii) to determine the predictive ability of the 2009 SIMCE results in determining the 2013 SIMCE outcomes for the 2010 5ESG cohort (when they graduated from elementary school, 8th grade) and for determining the 2013 University Selection Test (PSU) outcomes for the 2010 1HSG group (for university admission, when they graduated from high school, 4th grade); iii) to determine the association between the 2009 SIMCE results with the 2017 PSU outcomes for the 2010 5ESG group (for university admission, when they graduated from high school, 4th grade). A representative, proportional and stratified sample of 33 schools of the Metropolitan Region of Chile was randomly chosen. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212279PLOS
February 2019
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