442 results match your criteria Human T-Cell Lymphotrophic Viruses


Human T-cell lymphotropic virus type I and II seroprevalence among volunteer blood donors in Thailand.

Pathog Glob Health 2018 10 14;112(7):343-348. Epub 2018 Nov 14.

d Department of Transfusion Medicine and Clinical Microbiology, Faculty of Allied Health Sciences , Chulalongkorn University , Bangkok , Thailand.

Human T-cell lymphotrophic virus type I and II (HTLV-I/II) are closely related but distinct retroviruses that can infect humans. Both the viruses can be transmitted via transfusion of contaminated blood components. HTLV pre-transfusion screening is not mandatory in Thailand until now. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/20477724.2018.1541576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300747PMC
October 2018
2 Reads

Human T-lymphotropic virus 1 associated with adult T-cell leukemia/lymphoma.

Cutis 2018 Jul;102(1):E4-E7

Integrated Health Associates, Ann Arbor, Michigan, USA.

Adult T-cell leukemia/lymphoma (ATLL) is an uncommon neoplasm of mature T lymphocytes associated with infection by human T-lymphotropic virus 1 (HTLV-1), which is increasing in incidence in areas of the United States with large immigrant populations. Human T-lymphotrophic virus 1 infection is asymptomatic in most patients and has been associated with ATLL as well as tropical spastic paraparesis. Because there is considerable histologic overlap with other cutaneous T-cell lymphomas, high suspicion and clinical features must be present to make the diagnosis of ATLL. Read More

View Article

Download full-text PDF

Source
July 2018
3 Reads

The clinical impact of human T-lymphotrophic virus type 1 (HTLV-1) infection on the development of adult T-cell leukemia-lymphoma (ATL) or HTLV-1-associated myelopathy (HAM) / atypical HAM after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and renal transplantation.

J Clin Exp Hematop 2018 Sep 8;58(3):107-121. Epub 2018 Aug 8.

Because there are limited clinical reports on the impact of human T-lymphotropic virus type 1 (HTLV-1) on organ transplantation, its effects on the development of adult T-cell leukemia-lymphoma (ATL), post-transplantation lymphoproliferative disorder (PTLD) and HTLV-1-associated myelopathy (HAM) or atypical HAM after organ transplantation remain unclear.We retrospectively analyzed the impact of HTLV-1 in 54 allogeneic hematopoietic stem cell transplantation (allo-HSCT) cases and 31 renal transplantation cases between January 2006 and December 2016.Among the 54 allo-HSCT cases, nine recipients with ATL tested positive for HTLV-1, and one was found to be an HTLV-1 carrier. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3960/jslrt.18011DOI Listing
September 2018
5 Reads

Droplet digital PCR for absolute quantification of proviral load of human T-cell lymphotropic virus (HTLV) types 1 and 2.

J Virol Methods 2018 10 10;260:70-74. Epub 2018 Jul 10.

Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Background: Human T-lymphotrophic virus (HTLV) types 1 and 2 cause lifelong infection whereby most infected individuals are asymptomatic whilst a minority develop infection-related disease. These latter patients invariably have been found to have high proviral load (PVL). Therefore, infected patients are monitored by determining the proportion of lymphocytes that are infected with HTLV-1/2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jviromet.2018.07.003DOI Listing
October 2018
7 Reads

The Human T-Cell Leukemia Virus Type 1 Basic Leucine Zipper Factor Attenuates Repair of Double-Stranded DNA Breaks via Nonhomologous End Joining.

J Virol 2018 08 17;92(15). Epub 2018 Jul 17.

Brody School of Medicine, Department of Microbiology and Immunology, East Carolina University, Greenville, North Carolina, USA

Adult T-cell leukemia (ATL) is a fatal malignancy of CD4 T cells infected with human T-cell leukemia virus type 1 (HTLV-1). ATL cells often exhibit random gross chromosomal rearrangements that are associated with the induction and improper repair of double-stranded DNA breaks (DSBs). The viral oncoprotein Tax has been reported to impair DSB repair but has not been shown to be consistently expressed throughout all phases of infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00672-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052317PMC
August 2018
2 Reads

Unexpected donor-derived infectious transmissions by kidney transplantation: A systematic review.

Transpl Infect Dis 2018 Apr 6;20(2):e12851. Epub 2018 Mar 6.

Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, NSW, Australia.

Background: Unexpected donor-derived transmission of infections is rare, but is associated with significant morbidity and mortality. We aimed to provide an overview of published cases on unexpected infectious transmissions.

Methods: We systematically reviewed all published evidence describing any unexpected donor-derived viral, bacterial, fungal, and parasitic infections in kidney transplant recipients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tid.12851DOI Listing
April 2018
10 Reads

HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition.

Nat Commun 2018 01 30;9(1):431. Epub 2018 Jan 30.

Laboratory of Biology and Modelling of the Cell, ENS de Lyon, Univ Claude Bernard Lyon 1, CNRS UMR 5239, INSERM U1210, 46 allée d'Italie, 69364, Lyon, France.

Up-Frameshift Suppressor 1 Homolog (UPF1) is a key factor for nonsense-mediated mRNA decay (NMD), a cellular process that can actively degrade mRNAs. Here, we study NMD inhibition during infection by human T-cell lymphotropic virus type I (HTLV-1) and characterise the influence of the retroviral Tax factor on UPF1 activity. Tax interacts with the central helicase core domain of UPF1 and might plug the RNA channel of UPF1, reducing its affinity for nucleic acids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-017-02793-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789848PMC
January 2018
8 Reads

Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells.

Proc Natl Acad Sci U S A 2018 02 22;115(6):E1269-E1278. Epub 2018 Jan 22.

Laboratory of Virus Control, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan;

Viruses causing chronic infection artfully manipulate infected cells to enable viral persistence in vivo under the pressure of immunity. Human T-cell leukemia virus type 1 (HTLV-1) establishes persistent infection mainly in CD4+ T cells in vivo and induces leukemia in this subset. HTLV-1-encoded Tax is a critical transactivator of viral replication and a potent oncoprotein, but its significance in pathogenesis remains obscure due to its very low level of expression in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1715724115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819419PMC
February 2018
2 Reads

Interference of HTLV-1 Tax Protein with Cell Polarity Regulators: Defining the Subcellular Localization of the Tax-DLG1 Interaction.

Viruses 2017 11 23;9(12). Epub 2017 Nov 23.

Instituto de Biología Molecular y Celular de Rosario-CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina.

Human T cell leukemia virus (HTLV)-1 Tax (Tax) protein is very important in viral replication and cell transformation. Tax localizes in the nucleus and cytoplasm in association with organelles. Some activities of Tax depend on interactions with PDZ (PSD-95/Discs Large/Z0-1) domain-containing proteins such as Discs large protein 1 (DLG1) which is involved in cell polarity and proliferation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v9120355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744130PMC
November 2017
3 Reads

Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphoma.

Leuk Res 2017 10 18;61:18-24. Epub 2017 Aug 18.

Laboratory of Hematoimmunology, Graduate School of Health Sciences, University of the Ryukyus, Nishihara, Japan. Electronic address:

Okinawa, comprising remote islands off the mainland of Japan, is an endemic area of human T-cell leukemia virus type I (HTLV-1), the causative virus of adult T-cell leukemia-lymphoma (ATL) and HTLV-1-associated myelopathy (HAM). We investigated the tax genotype of HTLV-1 among 29 HTLV-1 carriers, 74 ATL patients, and 33 HAM patients in Okinawa. The genotype distribution-60 (44%) taxA cases and 76 (56%) taxB cases-differed from that of a previous report from Kagoshima Prefecture in mainland Japan (taxA, 10%; taxB, 90%). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.leukres.2017.08.006DOI Listing
October 2017
83 Reads

Extrafollicular activities: perspectives on HIV infection, germinal center-independent maturation pathways, and KSHV-mediated lymphoproliferation.

Curr Opin Virol 2017 10 3;26:69-73. Epub 2017 Aug 3.

Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, United States. Electronic address:

Early events in the pathogenesis of KSHV-associated lymphoproliferations in the context of HIV disease remain poorly understood. Recent research indicates that latent HIV infection causes persistent immune dysfunction in B cell follicles. Simultaneously, lack of T cell immune surveillance in the lymph nodes dysregulates the biology of EBV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coviro.2017.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673501PMC
October 2017
1 Read

Hijacking of the O-GlcNAcZYME complex by the HTLV-1 Tax oncoprotein facilitates viral transcription.

PLoS Pathog 2017 Jul 24;13(7):e1006518. Epub 2017 Jul 24.

INSERM, U1016, Institut Cochin, Paris, France.

The viral Tax oncoprotein plays a key role in both Human T-cell lymphotropic virus type 1 (HTLV-1)-replication and HTLV-1-associated pathologies, notably adult T-cell leukemia. Tax governs the transcription from the viral 5'LTR, enhancing thereby its own expression, via the recruitment of dimers of phosphorylated CREB to cAMP-response elements located within the U3 region (vCRE). In addition to phosphorylation, CREB is also the target of O-GlcNAcylation, another reversible post-translational modification involved in a wide range of diseases, including cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1006518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542696PMC
July 2017
18 Reads

A Unique T-Cell Receptor Amino Acid Sequence Selected by Human T-Cell Lymphotropic Virus Type 1 Tax-Specific Cytotoxic T Cells in HLA-A24:02-Positive Asymptomatic Carriers and Adult T-Cell Leukemia/Lymphoma Patients.

J Virol 2017 10 12;91(19). Epub 2017 Sep 12.

Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan

We previously reported that the T-cell receptor (TCR) repertoire of human T-cell lymphotropic virus type 1 (HTLV-1) Tax-specific CD8 cytotoxic T cells (Tax-CTLs) was highly restricted and a particular amino acid sequence motif, the PDR motif, was conserved among HLA-A*24:02-positive (HLA-A*24:02) adult T-cell leukemia/lymphoma (ATL) patients who had undergone allogeneic hematopoietic cell transplantation (allo-HSCT). Furthermore, we found that donor-derived PDR CTLs selectively expanded in ATL long-term HSCT survivors with strong CTL activity against HTLV-1. On the other hand, the TCR repertoires in Tax-CTLs of asymptomatic HTLV-1 carriers (ACs) remain unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00974-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599769PMC
October 2017
22 Reads

HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation.

Nat Commun 2017 06 22;8:15890. Epub 2017 Jun 22.

Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département de Virologie, Institut Pasteur, Paris F-75015, France.

The human T-lymphotropic virus type 1 (HTLV-1) is efficiently transmitted through cellular contacts. While the molecular mechanisms of viral cell-to-cell propagation have been extensively studied in vitro, those facilitating the encounter between infected and target cells remain unknown. In this study, we demonstrate that HTLV-1-infected CD4 T cells secrete a potent chemoattractant, leukotriene B4 (LTB4). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms15890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489682PMC
June 2017
30 Reads

Expression of HTLV-1 Genes in T-Cells Using RNA Electroporation.

Methods Mol Biol 2017 ;1582:155-170

Department of Surgery, Oncology and Gastroenterology, University of Padova, Via Gattamelata 64, Padova, 35128, Italy.

Human T-cell leukemia virus type 1 (HTLV-1) infects about 20 million people world-wide. Around 5% of the infected individuals develop adult T-cell leukemia (ATL) or a neurological disease termed tropical spastic paraparesis (TSP) after a clinical latency of years to decades. Through the use of two promoters and alternative splicing HTLV-1 expresses at least 12 different proteins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-6872-5_12DOI Listing
February 2018
4 Reads

Methods for Identifying and Examining HTLV-1 HBZ Post-translational Modifications.

Methods Mol Biol 2017 ;1582:111-126

Center for Retrovirus Research, The Ohio State University, Columbus, OH, 43210, USA.

Post-translational modifications (PTMs) are chemical alterations to individual amino acids that alter a protein's conformation, stability, and/or function. Several pathogenic viruses have been shown to encode proteins with PTMs, including human T-cell leukemia virus type 1 (HTLV-1) Tax and Rex regulatory proteins. HTLV-1 basic leucine zipper protein (HBZ) was hypothesized to feature PTMs due to its functional activities and interactions with cellular transcription factors and acetyltransferases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-6872-5_9DOI Listing
February 2018
2 Reads

Quantitative Analysis of Human T-Lymphotropic Virus Type 1 (HTLV-1) Infection Using Co-Culture with Jurkat LTR-Luciferase or Jurkat LTR-GFP Reporter Cells.

Methods Mol Biol 2017 ;1582:47-55

Equipe Oncogenèse Rétrovirale, Lyon, 69364 Cedex, 07, France.

Unlike HIV-1, HTLV-1 viral transmission requires cell-to-cell contacts, while cell-free virions are poorly infectious and almost absent from body fluids. Though the virus uses three nonexclusive mechanisms to infect new target cells: (1) MTOC polarization followed by formation of a virological synapse and viral transfer into a synaptic cleft, (2) genesis of a viral biofilm and its transfer of embedded viruses, or (3) HTLV-1 transmission using conduits. The Tax transactivator and the p8 viral proteins are involved in virological synapse and nanotube formation respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-6872-5_4DOI Listing
February 2018
3 Reads

An Autopsy Case Report of Adult T-cell Leukemia Accompanied by Rheumatoid Arthritis Mimicking Diffuse Panbronchiolitis.

J UOEH 2017 ;39(1):55-61

Department of Respiratory Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

A 50-year-old female with a history of chronic sinusitis and rheumatoid arthritis visited our department with repetitive lower respiratory tract infections of Pseudomonas aeruginosa. Her chest CT showed diffuse panbronchiolitis-like pulmonary lesions, her blood examination revealed atypical lymphocytes, and she was serologically positive for anti-human T-lymphotrophic virus type 1 (HTLV-1) antibody. Her rheumatoid arthritis had been well-controlled after biological agent treatment followed by anti-inflammatory analgesic treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7888/juoeh.39.55DOI Listing
June 2017
15 Reads

Effects of expressing human T-cell leukemia virus type 1 (HTLV-I) oncoprotein Tax on DOK1, DOK2 and DOK3 gene expression in mice.

Authors:
Takeo Ohsugi

J Vet Med Sci 2017 May 12;79(5):935-938. Epub 2017 Mar 12.

Department of Laboratory Animal Science, School of Veterinary Medicine, Rakuno-Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan.

Transgenic mice expressing the tax gene from human T-cell leukemia virus type 1 (HTLV-I) genome developed T-cell leukemia or histiocytic sarcoma after at least 12 months. The transgenic mice showed low expression of the downstream of tyrosine kinase (DOK) family members, DOK1, DOK2 and DOK3, which were recently reported to be tumor suppressor genes. Mice showed low DOK2 expression at 5-6 months of age, before disease onset. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1292/jvms.17-0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447985PMC
May 2017
2 Reads

HTLV-1 Tax activates HIV-1 transcription in latency models.

Virology 2017 04 30;504:45-51. Epub 2017 Jan 30.

Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil. Electronic address:

HIV-1 latency is a major obstacle to HIV-1 eradication. Coinfection with HTLV-1 has been associated with faster progression to AIDS. HTLV-1 encodes the transactivator Tax which can activate both HTLV-1 and HIV-1 transcription. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2017.01.014DOI Listing
April 2017
23 Reads

Seroprevalence and geographical distribution of human T-lymphotropic virus type 1 among volunteer blood donors in endemic areas of Iran.

Virol J 2017 01 30;14(1):14. Epub 2017 Jan 30.

Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Hemmat Exp. Way, Next to the Milad Tower, Tehran, Iran.

Background: Human T-cell lymphotrophic virus type 1 (HTLV-1) has a worldwide distribution and it is endemic in some regions of Iran. One of the most important routes of HTLV-1 transmission is via transfusion of contaminated blood components. The risk of transmission through asymptomatic blood donors, particularly in endemic areas should be considered and appropriately managed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12985-017-0693-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282699PMC
January 2017
7 Reads

The sense behind retroviral anti-sense transcription.

Virol J 2017 01 14;14(1). Epub 2017 Jan 14.

Department of Immunology, University of Manitoba, Winnipeg, MB, Canada.

Retroviruses are known to rely extensively on the expression of viral proteins from the sense proviral genomic strand. Yet, the production of regulatory retroviral proteins from antisense-encoded viral genes is gaining research attention, due to their clinical significance. This report will discuss what is known about antisense transcription in Retroviridae, and provide new information about antisense transcriptional regulation through a comparison of Human Immunodeficiency Virus (HIV), Human T-cell Lymphotrophic Virus (HTLV-1) and endogenous retrovirus-K (ERVK) long terminal repeats (LTRs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12985-016-0667-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237517PMC
January 2017
26 Reads

HTLV-1 Tax-Specific CTL Epitope-Pulsed Dendritic Cell Therapy Reduces Proviral Load in Infected Rats with Immune Tolerance against Tax.

J Immunol 2017 02 23;198(3):1210-1219. Epub 2016 Dec 23.

Department of Immunotherapeutics, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.

Adult T cell leukemia/lymphoma (ATL), a CD4 T cell malignancy with a poor prognosis, is caused by human T cell leukemia virus type 1 (HTLV-1) infection. High proviral load (PVL) is a risk factor for the progression to ATL. We previously reported that some asymptomatic carriers had severely reduced functions of CTLs against HTLV-1 Tax, the major target Ag. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1601557DOI Listing
February 2017
7 Reads

Role of the HTLV-1 viral factors in the induction of apoptosis.

Biomed Pharmacother 2017 Jan 23;85:334-347. Epub 2016 Nov 23.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Adult T-cell leukemia (ATL) and HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) are the two main diseases that are caused by the HTLV-1 virus. One of the features of HTLV-1 infection is its resistance against programmed cell death, which maintains the survival of cells to oncogenic transformation and underlies the viruses' therapeutic resistance. Two main genes by which the virus develops cancer are Tax and HBZ; playing an essential role in angiogenesis in regulating viral transcription and modulating multiple host factors as well as apoptosis pathways. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopha.2016.11.034DOI Listing
January 2017
10 Reads

Dysregulation of c-Myb Pathway by Aberrant Expression of Proto-oncogene MYB Provides the Basis for Malignancy in Adult T-cell Leukemia/lymphoma Cells.

Clin Cancer Res 2016 Dec 15;22(23):5915-5928. Epub 2016 Jun 15.

Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.

Purpose: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive human T-cell malignancy induced by human T-lymphotrophic virus-1 (HTLV-1) infection. The genetic alterations in infected cells that lead to transformation have not been completely elucidated, thus hindering the identification of effective therapeutic targets for ATL. Here, we present the first assessment of MYB proto-oncogene dysregulation in ATL and an exploration of its role in the onset of ATL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-15-1739DOI Listing
December 2016
6 Reads

The Tax-Inducible Actin-Bundling Protein Fascin Is Crucial for Release and Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1 (HTLV-1).

PLoS Pathog 2016 Oct 24;12(10):e1005916. Epub 2016 Oct 24.

Institute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

The delta-retrovirus Human T-cell leukemia virus type 1 (HTLV-1) preferentially infects CD4+ T-cells via cell-to-cell transmission. Viruses are transmitted by polarized budding and by transfer of viral biofilms at the virological synapse (VS). Formation of the VS requires the viral Tax protein and polarization of the host cytoskeleton, however, molecular mechanisms of HTLV-1 cell-to-cell transmission remain incompletely understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1005916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077169PMC
October 2016
33 Reads

Not the Usual Viral Suspects: Parvovirus B19, West Nile Virus, and Human T-Cell Lymphotrophic Virus Infections After Kidney Transplantation.

Semin Nephrol 2016 09;36(5):428-434

Division of Infectious Diseases and the William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN. Electronic address:

Kidney transplant recipients are at increased risk of developing clinical disease due to uncommon opportunistic viral pathogens. Refractory anemia is classically associated with parvovirus B19 infection. West Nile virus has the propensity to cause fever and neurologic symptoms, while spastic paresis and lymphoma can be triggered by human T cell lymphotrophic virus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semnephrol.2016.05.019DOI Listing
September 2016
6 Reads

HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma-A Tale of Two Proteins: Tax and HBZ.

Viruses 2016 06 16;8(6). Epub 2016 Jun 16.

Department of Microbiology and Molecular Cell Biology, The Leroy T. Canoles Jr Cancer Research Center, Eastern Virginia Medical School, Norfolk, VA 23501, USA.

HTLV-1 (Human T-cell lymphotropic virus type 1) is a complex human delta retrovirus that currently infects 10-20 million people worldwide. While HTLV-1 infection is generally asymptomatic, 3%-5% of infected individuals develop a highly malignant and intractable T-cell neoplasm known as adult T-cell leukemia/lymphoma (ATL) decades after infection. How HTLV-1 infection progresses to ATL is not well understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v8060161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926181PMC
June 2016
3 Reads

Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells.

Acta Virol 2016 Jun;60(2):211-3

Human T-cell leukemia virus type 1 (HTLV-1) can cause an aggressive malignancy known as adult T-cell leukemia/lymphoma (ATLL). The Tax protein encoded by the pX region of the HTLV-1 genome appears to be a key element in the early stage of ATLL development. In this study, we examined the expression of the downstream of tyrosine kinase (DOK) family members DOK1, DOK2 and DOK3, recently reported to be tumor suppressors, in HTLV-1-transformed T cells (MT-2 and HUT-102) and TL-Om1 cells derived from ATLL leukemic cells. Read More

View Article

Download full-text PDF

Source
June 2016
2 Reads

Human T-Lymphotropic Virus Type 1-Induced Overexpression of Activated Leukocyte Cell Adhesion Molecule (ALCAM) Facilitates Trafficking of Infected Lymphocytes through the Blood-Brain Barrier.

J Virol 2016 08 27;90(16):7303-7312. Epub 2016 Jul 27.

Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département de Virologie, Institut Pasteur, Paris, France

Unlabelled: Human T-lymphotropic virus type 1 (HTLV-1) is the etiological agent of a slowly progressive neurodegenerative disease, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). This disease develops upon infiltration of HTLV-1-infected lymphocytes into the central nervous system, mostly the thoracic spinal cord. The central nervous system is normally protected by a physiological structure called the blood-brain barrier (BBB), which consists primarily of a continuous endothelium with tight junctions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00539-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984663PMC
August 2016
77 Reads

Viral oncomiR spreading between B and T cells is employed by Kaposi's sarcoma herpesvirus to induce non-cell-autonomous target gene regulation.

Oncotarget 2016 Jul;7(27):41870-41884

Sheba Cancer Research Center, Chaim Sheba Academic Medical Center, Tel Hashomer, Ramat Gan 5262100, Israel.

The two human lymphotrophic γ-herpesviruses, Kaposi's sarcoma herpesvirus (KSHV) and Epstein-Barr virus (EBV), are a recognized cause of human cancer, encoding multiple miRs that are major players in carcinogenesis. Previously, we discovered that EBV-encoded miRs transfer between infected B and T lymphocytes. To further explore the biological significance of the spreading of γ-herpesvirus-encoded miRs on carcinogenesis, we focused on KSHV-miR-K12-11 (miR-K12-11) that is unique in having an identical seed sequence with the oncomiR hsa-miR-155, implicated in B cell lymphomas development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.9627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173102PMC
July 2016
47 Reads

Historical review of the causes of cancer.

World J Clin Oncol 2016 Feb;7(1):54-86

Clarke Brian Blackadar, Department of Food Science, Ontario Agricultural College, University of Guelph, Guelph, ON N1G 2W1, Canada.

In the early 1900s, numerous seminal publications reported that high rates of cancer occurred in certain occupations. During this period, work with infectious agents produced only meager results which seemed irrelevant to humans. Then in the 1980s ground breaking evidence began to emerge that a variety of viruses also cause cancer in humans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5306/wjco.v7.i1.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734938PMC
February 2016
2 Reads

The Major Histocompatibility Complex Class II Transactivator CIITA Inhibits the Persistent Activation of NF-κB by the Human T Cell Lymphotropic Virus Type 1 Tax-1 Oncoprotein.

J Virol 2016 Jan 20;90(7):3708-21. Epub 2016 Jan 20.

General Pathology and Immunology Laboratory, Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy

Unlabelled: Human T cell lymphotropic virus type 1 (HTLV-1) Tax-1, a key protein in HTLV-1-induced T cell transformation, deregulates diverse cell signaling pathways. Among them, the NF-κB pathway is constitutively activated by Tax-1, which binds to NF-κB proteins and activates the IκB kinase (IKK). Upon phosphorylation-dependent IκB degradation, NF-κB migrates into the nucleus, mediating Tax-1-stimulated gene expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.03000-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794681PMC
January 2016
4 Reads

Polycomb-dependent epigenetic landscape in adult T-cell leukemia.

Blood 2016 Apr 15;127(14):1790-802. Epub 2016 Jan 15.

Graduate School of Frontier Sciences, Department of Computational Biology and Medical Sciences, and.

Adult T-cell leukemia-lymphoma (ATL) shows global gene expression alterations that confer cellular characteristics and unfavorable prognosis. However, molecular mechanisms of the sustained expression changes are largely unknown, because there is no study addressing the relationship between landscapes of the gene expression and epigenetic modifications. Here, we analyzed ATL epigenome and integrated it with transcriptome from primary ATL cells and those from corresponding normal CD4(+)T cells to decipher ATL-specific "epigenetic code" that was critical for cell identity. Read More

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/content/early/2016/01/15/blood-2
Web Search
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-08-66
Publisher Site
http://dx.doi.org/10.1182/blood-2015-08-662593DOI Listing
April 2016
27 Reads

Retrospective clinic and urodynamic study in the neurogenic bladder dysfunction caused by human T cell lymphotrophic virus type 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP).

Neurourol Urodyn 2017 02 12;36(2):449-452. Epub 2016 Jan 12.

Rehabilitation Unit, University Hospital Martinique, France.

Introduction: HTLV-I associated tropical spastic paraparesis (TSP) and HTLV-I associated myelopathy (HAM) is an endemic disease in Caribbean Island. Bladder-sphincter dysfunctions are almost present. The objectives of the study are to describe clinic and urodynamic characteristics of voiding disorders in Martiniquan population, evaluate if there is a relationship between motor and urinary handicap, and evaluate prognosis factors of urologic complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/nau.22952DOI Listing
February 2017
4 Reads

Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB.

Virus Genes 2016 Feb 6;52(1):4-13. Epub 2016 Jan 6.

Divisions of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-Dori, Niigata, 951-8510, Japan.

Human T-cell leukemia virus type 1 (HTLV-1) is a causative retrovirus of adult T-cell leukemia and HTLV-1-associated myelopathy. Unlike HTLV-1, the same group of retrovirus HTLV-2 has not been found to be associated with these diseases. HTLV-1 and HTLV-2 encode transforming proteins Tax1 and Tax2, and a few distinct activities of Tax1 from those of Tax2 have been proposed to contribute to the HTLV-1-specific pathogenesis of disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11262-015-1277-7DOI Listing
February 2016
21 Reads

Molecular Detection and Clinical Implications of HTLV-1 Infections among Antiretroviral Therapy-Naïve HIV-1-Infected Individuals in Abuja, Nigeria.

Virology (Auckl) 2015 14;6:17-23. Epub 2015 Dec 14.

Department of Medical Microbiology, Abubakar Tafawa Balewa University Teaching Hospital, Bauchi State, Nigeria.

Background: Individuals with human T-cell lymphotrophic virus type-1 (HTLV-1)/HIV-1 coinfection have been demonstrated to undergo CD4+ lymphocytosis even in the face of immunodeficiency and increased vulnerability to opportunistic pathogens that can lead to poor prognosis.

Objective: This study investigated the prevalence as well as the effects of HIV-1/HTLV-1 coinfection on CD4+ cell counts, routine hematology, and biochemical parameters of study participants.

Materials And Methods: This prospective cross-sectional study involved 184 blood samples collected from HIV-1-seropositive individuals attending HIV-special clinic of the University of Abuja Teaching Hospital, Gwagwalada, Nigeria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4137/VRT.S35331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678997PMC
December 2015
31 Reads
3 Citations

Hypomethylation of the Treg-Specific Demethylated Region in FOXP3 Is a Hallmark of the Regulatory T-cell Subtype in Adult T-cell Leukemia.

Cancer Immunol Res 2016 Feb 17;4(2):136-45. Epub 2015 Dec 17.

Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Adult T-cell leukemia (ATL) is an aggressive T-cell malignancy caused by human T-cell leukemia virus type 1. Because of its immunosuppressive property and resistance to treatment, patients with ATL have poor prognoses. ATL cells possess the regulatory T cell (Treg) phenotype, such as CD4 and CD25, and usually express forkhead box P3 (FOXP3). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2326-6066.CIR-15-0148DOI Listing
February 2016
56 Reads
1 Citation

HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors.

J Neurovirol 2016 08 3;22(4):416-30. Epub 2015 Dec 3.

Department of Microbiology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan.

Among human T cell leukemia virus type 1 (HTLV-1)-infected individuals, the risk of developing HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) across lifetime differs between ethnic groups. There is an association between HTLV-1 tax gene subgroups (subgroup-A or subgroup-B) and the risk of HAM/TSP in the Japanese population. In this study, we investigated the full-length proviral genome sequences of various HTLV-1-infected cell lines and patient samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13365-015-0407-2DOI Listing
August 2016
13 Reads

Molecular Pathology of Adult T-Cell Leukemia/Lymphoma.

Authors:
Koichi Ohshima

Oncology 2015 10;89 Suppl 1:7-15. Epub 2015 Nov 10.

Department of Pathology, School of Medicine, Kurume University, Kurume, Japan.

Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell neoplasm of highly pleomorphic lymphoid cells. ATLL is usually widely disseminated, and it is caused by human T-cell leukemia virus type 1 (HTLV-1). It is a disease with a long latency, and affected individuals are usually exposed to the virus very early in life. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/431058
Publisher Site
http://dx.doi.org/10.1159/000431058DOI Listing
February 2016
21 Reads

Low Proviral Load is Associated with Indeterminate Western Blot Patterns in Human T-Cell Lymphotropic Virus Type 1 Infected Individuals: Could Punctual Mutations be Related?

Viruses 2015 Oct 28;7(11):5643-58. Epub 2015 Oct 28.

Instituto de Investigaciones Biomédicas en Retrovirus y SIDA, UBA-CONICET, Paraguay 2155, piso 11, C1121ABG, CABA, Argentina.

Background: indeterminate Western blot (WB) patterns are a major concern for diagnosis of human T-cell lymphotropic virus type 1 (HTLV-1) infection, even in non-endemic areas.

Objectives: (a) to define the prevalence of indeterminate WB among different populations from Argentina; (b) to evaluate if low proviral load (PVL) is associated with indeterminate WB profiles; and (c) to describe mutations in LTR and tax sequence of these cases.

Results: Among 2031 samples, 294 were reactive by screening. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/1999-4915/7/11/2897
Publisher Site
http://dx.doi.org/10.3390/v7112897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664970PMC
October 2015
10 Reads

I-mfa domain proteins specifically interact with HTLV-1 Tax and repress its transactivating functions.

Virology 2015 Dec 27;486:219-27. Epub 2015 Oct 27.

Division of Persistent and Oncogenic Viruses, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan.

The I-mfa domain proteins HIC (also known as MDFIC) and I-mfa (also known as MDFI) are candidate tumor suppressor genes that are involved in cellular and viral transcriptional regulation. Here, we show that HIC and I-mfa directly interact with human T-cell leukemia virus type-1 (HTLV-1) Tax protein in vitro. In addition, HIC and I-mfa repress Tax-dependent transactivation of an HTLV-1 long terminal repeat (LTR) reporter construct in COS-1, Jurkat and high-Tax-producing HTLV-1-infected T cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2015.09.020DOI Listing
December 2015
9 Reads

Integrated molecular analysis of adult T cell leukemia/lymphoma.

Nat Genet 2015 Nov 5;47(11):1304-15. Epub 2015 Oct 5.

Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Adult T cell leukemia/lymphoma (ATL) is a peripheral T cell neoplasm of largely unknown genetic basis, associated with human T cell leukemia virus type-1 (HTLV-1) infection. Here we describe an integrated molecular study in which we performed whole-genome, exome, transcriptome and targeted resequencing, as well as array-based copy number and methylation analyses, in a total of 426 ATL cases. The identified alterations overlap significantly with the HTLV-1 Tax interactome and are highly enriched for T cell receptor-NF-κB signaling, T cell trafficking and other T cell-related pathways as well as immunosurveillance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3415DOI Listing
November 2015
101 Reads

Foxp3-dependent transformation of human primary CD4+ T lymphocytes by the retroviral protein tax.

Biochem Biophys Res Commun 2015 Oct 14;466(3):523-9. Epub 2015 Sep 14.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Departments of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Departments of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

The retroviral Tax proteins of human T cell leukemia virus type 1 and 2 (HTLV-1 and -2) are highly homologous viral transactivators. Both viral proteins can immortalize human primary CD4+ memory T cells, but when expressed alone they rarely transform T cells. In the present study, we found that the Tax proteins displayed a differential ability to immortalize human CD4+Foxp3+ T cells with characteristic expression of CTLA-4 and GITR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2015.09.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617533PMC
October 2015
2 Reads

Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.

J Biol Chem 2015 Oct 31;290(43):26270-81. Epub 2015 Aug 31.

From the Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110 and

Human T-cell leukemia virus (HTLV) type 1, the etiological agent of adult T-cell leukemia, expresses the viral oncoprotein Tax1. In contrast, HTLV-2, which expresses Tax2, is non-leukemogenic. One difference between these homologous proteins is the presence of a C-terminal PDZ domain-binding motif (PBM) in Tax1, previously reported to be important for non-canonical NFκB activation. Read More

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M115.684746
Publisher Site
http://dx.doi.org/10.1074/jbc.M115.684746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646275PMC
October 2015
11 Reads

The autophagy molecule Beclin 1 maintains persistent activity of NF-κB and Stat3 in HTLV-1-transformed T lymphocytes.

Biochem Biophys Res Commun 2015 Oct 25;465(4):739-45. Epub 2015 Aug 25.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

The retroviral oncoprotein Tax from human T cell leukemia virus type 1 (HTLV-1) induces persistent activation of IκB kinase (IKK)/NF-κB signaling, an essential step for initiating HTLV-1 oncogenesis. The regulation of the IKK/NF-κB signaling in HTLV-1-transformed T cells remains incompletely understood. In the present study, we showed that the autophagy molecule Beclin1 not only executed a cytoprotective function through induction of autophagy but also played a pivotal role in maintaining Tax-induced activation of two key survival factors, NF-κB and Stat3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2015.08.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580621PMC
October 2015
1 Read

Viral Co-infection and Leprosy Outcomes: A Cohort Study.

PLoS Negl Trop Dis 2015 12;9(8):e0003865. Epub 2015 Aug 12.

Department of Medicine, Division of Infectious Diseases, Weill Cornell Medical College, New York, New York, United States of America.

Background: The role of the host immunity in determining leprosy clinical forms and complications is well recognized, implying that changes in the immune status may interfere with several aspects of the disease. Therefore, we hypothesized that the presence of viral co-infections and associated immunological changes will have a clinical impact on leprosy outcomes. The aim of our study was to determine the clinical impact of human immunodeficiency virus (HIV), human T cell lymphotrophic virus type 1 (HTLV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infection on the development of reactions, neuritis, neuropathy and relapses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0003865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534371PMC
April 2016
12 Reads

Inducible nitric oxide synthase mediates DNA double strand breaks in Human T-Cell Leukemia Virus Type 1-induced leukemia/lymphoma.

Retrovirology 2015 Aug 12;12:71. Epub 2015 Aug 12.

Division of Molecular Oncology, Department of Medicine Campus, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO, 63110, USA.

Background: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive and fatal malignancy of CD4(+) T-lymphocytes infected by the Human T-Cell Virus Type 1 (HTLV-1). The molecular mechanisms of transformation in ATLL have not been fully elucidated. However, genomic instability and cumulative DNA damage during the long period of latency is believed to be essential for HTLV-1 induced leukemogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12977-015-0196-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534112PMC
August 2015
21 Reads

Hepatitis C virus infection and spontaneous clearance in HTLV-1 and HIV co-infected patients in Salvador, Bahia, Brazil.

Braz J Infect Dis 2015 Sep-Oct;19(5):486-91. Epub 2015 Aug 5.

Department of Infectious Disease, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil. Electronic address:

Background: While 20-40% of patients with hepatitis C virus (HCV) monoinfection will spontaneously clear the virus, less is known regarding clearance with coinfections. HCV, human immunodeficiency virus (HIV), and human T-cell lymphotrophic virus 1 and 2 (HTLV-1/2) coinfection occurs due to shared routes of transmission and is prevalent in Brazil.

Objectives: To compare the proportion of patients who have spontaneously cleared HCV in patients with HCV monoinfection to patients coinfected by HCV/HIV, or HCV/HIV/HTLV-1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bjid.2015.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592833PMC
May 2016
3 Reads

The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis.

Viruses 2015 Jul 20;7(7):4047-74. Epub 2015 Jul 20.

Department of Pathology and Laboratory Medicine, Center for Viral Oncology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.

Human T-cell leukemia virus (HTLV)-1 is a human retrovirus and the etiological agent of adult T-cell leukemia/lymphoma (ATLL), a fatal malignancy of CD4/CD25+ T lymphocytes. In recent years, cellular as well as virus-encoded microRNA (miRNA) have been shown to deregulate signaling pathways to favor virus life cycle. HTLV-1 does not encode miRNA, but several studies have demonstrated that cellular miRNA expression is affected in infected cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v7072805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517134PMC
July 2015
6 Reads