458 results match your criteria Human T-Cell Lymphotrophic Viruses


Clinical features and treatment outcomes of opportunistic infections among human T-lymphotrophic virus type 1 (HTLV-1) carriers and patients with adult T-cell leukemia-lymphoma (ATL) at a single institution from 2006 to 2016.

J Clin Exp Hematop 2019 ;59(4):156-167

As opportunistic infections among human T-lymphotrophic virus type 1 (HTLV-1) carriers and patients with adult T-cell leukemia/lymphoma (ATL) pose a serious problem, it is necessary to clarify their clinical characteristics and outcomes in these patients. We retrospectively analyzed the clinical features and outcomes of opportunistic infections in 127 HTLV-1 carriers and 153 ATL patients between 2006 and 2016. The cumulative incidence rates of opportunistic infections among HTLV-1 carriers and ATL patients were 1. Read More

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http://dx.doi.org/10.3960/jslrt.18032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954174PMC

EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses.

Virol J 2019 12 19;16(1):160. Epub 2019 Dec 19.

Department of Microbiology, Kawasaki Medical School, 577 Matsushima, Okayama, 701-0192, Japan.

Background: EOS plays an important role in maintaining the suppressive function of regulatory T cells (Tregs), and induces a regulated transformation of Tregs into T helper-like cells, which are capable of secreting proinflammatory cytokines in response to specific inflammatory signals. Meanwhile, significant reduction in Treg activity along with production of proinflammatory cytokines has been reported in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).

Methods: In this study, to examine whether there is an alteration in EOS expression in peripheral blood mononuclear cells (PBMCs) derived from HTLV-1-infected individuals especially HAM/TSP, we investigated the expression of HTLV-1 tax genotype, proviral load (PVL), and the mRNA expression of tax, HBZ and EOS in HTLV-1 infected individuals including adult T-cell leukemia/lymphoma (ATL), HAM/TSP, or asymptomatic carriers. Read More

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http://dx.doi.org/10.1186/s12985-019-1270-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923961PMC
December 2019

The ESCRT-0 Protein HRS Interacts with the Human T Cell Leukemia Virus Type 2 Antisense Protein APH-2 and Suppresses Viral Replication.

J Virol 2019 12 12;94(1). Epub 2019 Dec 12.

Centre for Research in Infectious Diseases, School of Medicine, University College Dublin, Dublin, Ireland

The divergent clinical outcomes of human T cell leukemia virus type 1 (HTLV-1) and HTLV-2 infections have been attributed to functional differences in their antisense proteins. In contrast to HTLV-1 bZIP factor (HBZ), the role of the antisense protein of HTLV-2 (APH-2) in HTLV-2 infection is poorly understood. In previous studies, we identified the endosomal sorting complex required for transport 0 (ESCRT-0) subunit HRS as a novel interaction partner of APH-2 but not HBZ. Read More

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http://dx.doi.org/10.1128/JVI.01311-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912118PMC
December 2019

Flow cytometric methodology for the detection of de novo human T-cell leukemia virus -1 infection in vitro: A tool to study novel infection inhibitors.

J Virol Methods 2019 12 8;274:113728. Epub 2019 Sep 8.

Department of Biology & Hull York Medical School, University of York, UK. Electronic address:

Methodology to detect and study de novo human T-cell leukemia virus (HTLV)-1 infection is required to further our knowledge of the viruses' mechanisms of infection and to study potential therapeutic interventions. Whilst methodology currently exists, utilisation of an anti-Tax antibody to detect de novo Tax expression in permissive cells labelled with cell tracker allowing for the detection by flow cytometry of new infection after co-culture with donor cell lines productively infected with HTLV-1 is an alternative strategy. Using this methodology, we have been able to detect de novo infection of the T cell line HUT78 following co-culture with the productively infected HTLV-1 donor cell line MT-2 and to confirm that infection can be effectively blocked with well characterised infection inhibitors. Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.113728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853161PMC
December 2019

Prevalence of human T-cell lymphotropic virus and the socio-demographic and risk factors associated with the infection among post-natal clinics women in Zaria, Nigeria.

J Immunoassay Immunochem 2019 24;40(5):485-494. Epub 2019 Jul 24.

Department of Microbiology, Ahmadu Bello University , Zaria , Nigeria.

Human T-cell lymphotropic virus has long been associated with Adult T-cell leukemia/lymphoma, HTLV-associated myelopathy/tropical spastic paraparesis, and hairy cell leukemia. The aim was to determine the prevalence of HTLV antibodies as well as the socio-demographic and risk factors associated with HTLV among women attending postnatal clinics in Zaria. A total of 190 samples were collected within the months of January and June 2017 and qualitative determination of antibodies for HTLV in serum was performed by an antigen sandwich enzyme immunoassay method. Read More

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http://dx.doi.org/10.1080/15321819.2019.1636817DOI Listing
October 2019
3 Reads

The human T-cell leukemia virus type-1 tax oncoprotein dissociates NF-κB p65-Stathmin complexes and causes catastrophic mitotic spindle damage and genomic instability.

Virology 2019 09 3;535:83-101. Epub 2019 Jul 3.

Laboratory of Molecular Virology, Department of Biological Sciences, The Dedman College Center for Drug Discovery, Design & Delivery, Southern Methodist University, Dallas, TX, 75275-0376, United States. Electronic address:

Genomic instability is a hallmark of many cancers; however, the molecular etiology of chromosomal dysregulation is not well understood. The human T-cell leukemia virus type-1 (HTLV-1) oncoprotein Tax activates NF-κB-signaling and induces DNA-damage and aberrant chromosomal segregation through diverse mechanisms which contribute to viral carcinogenesis. Intriguingly, Stathmin/oncoprotein-18 (Op-18) depolymerizes tubulin and interacts with the p65 subunit and functions as a cofactor for NF-κB-dependent transactivation. Read More

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http://dx.doi.org/10.1016/j.virol.2019.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940561PMC
September 2019

HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I.

PLoS Pathog 2019 06 28;15(6):e1007922. Epub 2019 Jun 28.

Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America.

Adult T-cell Leukemia (ATL) is a lymphoproliferative disease of CD4+ T-cells infected with Human T-cell Leukemia Virus type I (HTLV-1). With the exception of allogeneic hematopoietic stem cell transplantation, there are no effective treatments to cure ATL, and ATL cells often acquire resistance to conventional chemotherapeutic agents. Accumulating evidence shows that development and maintenance of ATL requires key contributions from the viral protein, HTLV-1 basic leucine zipper factor (HBZ). Read More

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http://dx.doi.org/10.1371/journal.ppat.1007922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6623464PMC
June 2019
4 Reads

Novel Interactions between the Human T-Cell Leukemia Virus Type 1 Antisense Protein HBZ and the SWI/SNF Chromatin Remodeling Family: Implications for Viral Life Cycle.

J Virol 2019 08 30;93(16). Epub 2019 Jul 30.

Centre for Research in Infectious Diseases, School of Medicine, University College Dublin, Dublin, Ireland

The human T-cell leukemia virus type 1 (HTLV-1) regulatory proteins Tax and HBZ play indispensable roles in regulating viral and cellular gene expression. BRG1, the ATPase subunit of the SWI/SNF chromatin remodeling complex, has been demonstrated to be essential not only for Tax transactivation but also for viral replication. We sought to investigate the physical interaction between HBZ and BRG1 and to determine the effect of these interactions on Tax-mediated long terminal repeat (LTR) activation. Read More

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http://dx.doi.org/10.1128/JVI.00412-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675893PMC
August 2019
5 Reads

HTLV-1 Tax-1 interacts with SNX27 to regulate cellular localization of the HTLV-1 receptor molecule, GLUT1.

PLoS One 2019 21;14(3):e0214059. Epub 2019 Mar 21.

Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, United States of America.

An estimated 10-20 million people worldwide are infected with human T cell leukemia virus type 1 (HTLV-1), with endemic areas of infection in Japan, Australia, the Caribbean, and Africa. HTLV-1 is the causative agent of adult T cell leukemia (ATL) and HTLV-1 associated myopathy/tropic spastic paraparesis (HAM/TSP). HTLV-1 expresses several regulatory and accessory genes that function at different stages of the virus life cycle. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214059PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428263PMC
December 2019
12 Reads

[Primary cutaneous localization revealing leukemia/T-cell lymphoma associated with chronic HTLV-1 infection in a adult. A case presentation].

Ann Pathol 2019 Feb 19;39(1):40-46. Epub 2018 Dec 19.

Centre hospitalier universitaire Aristide le Dantec, service d'hématologie, avenue Pasteur, BP 3001, Dakar, Sénégal.

Adult T-cell leukemia/lymphoma (ATLL) is a rare medical condition and a diagnosis that ought to be considered for patients living in an area endemic for the HTLV-1 virus (human T-lymphotrophic virus) where a T-cell lymphoproliferative diagnosis has been made. The cutaneous clinical forms may be the first manifestation of the disease. We report here an observation in a 60-year-old Senegalese woman whose skin lesions were sampled to reveal the ATLL immunophenotypic profile CD4+, CD25+, FoxP3-, and CD7-. Read More

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http://dx.doi.org/10.1016/j.annpat.2018.10.001DOI Listing
February 2019
7 Reads

Diversity of cell phenotypes among MT-2 cell lines affects the growth of U937 cells and cytokine production.

Hum Cell 2019 Apr 17;32(2):185-192. Epub 2018 Dec 17.

Department of Rheumatology, Infectious Diseases and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.

We previously reported the diversity of structure and integration sites of human T-cell leukemia virus type 1 (HTLV-1) provirus among different MT-2 cell lines. This raised the question as to whether cell phenotypes also differed among MT-2 cell lines. The influence of two different MT-2 cell lines (MT-2J and MT-2B) on the growth of the promonocytic leukemia cell line, U937, was investigated. Read More

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http://dx.doi.org/10.1007/s13577-018-00231-3DOI Listing
April 2019
10 Reads

Human T-cell lymphotropic virus type I and II seroprevalence among volunteer blood donors in Thailand.

Pathog Glob Health 2018 10 14;112(7):343-348. Epub 2018 Nov 14.

d Department of Transfusion Medicine and Clinical Microbiology, Faculty of Allied Health Sciences , Chulalongkorn University , Bangkok , Thailand.

Human T-cell lymphotrophic virus type I and II (HTLV-I/II) are closely related but distinct retroviruses that can infect humans. Both the viruses can be transmitted via transfusion of contaminated blood components. HTLV pre-transfusion screening is not mandatory in Thailand until now. Read More

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http://dx.doi.org/10.1080/20477724.2018.1541576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300747PMC
October 2018
12 Reads

[Genetic analysis and its clinical implication in adult T-cell leukemia/lymphoma].

Rinsho Ketsueki 2018;59(10):2127-2135

Division of Molecular Oncology, National Cancer Center Research Institute.

Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell neoplasm with a dismal prognosis. This disease is caused by human T-cell leukemia virus type-1 (HTLV-1) retrovirus. Not only viral proteins, such as Tax and HBZ, but also additional genetic and epigenetic aberrations, including gain-of-function alterations in the components of T-cell receptor/NF-κB pathway or deteriorating alterations responsible for immune surveillance, are essential for ATL development and progression. Read More

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https://www.jstage.jst.go.jp/article/rinketsu/59/10/59_2127/
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http://dx.doi.org/10.11406/rinketsu.59.2127DOI Listing
July 2019
8 Reads

-mRNA-Carrying Exosomes from Human T Cell Lymphotropic Virus Type 1-Infected Cells Can Induce Interferon-Gamma Production .

AIDS Res Hum Retroviruses 2018 12 1;34(12):1075-1082. Epub 2018 Nov 1.

Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

Human T cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukemia/lymphoma. The development of HAM/TSP, a chronic neuroinflammatory disease, is correlated to complex interaction between the host immune response and the infecting virus. Tax expression plays an important role in HAM/TSP pathogenesis by activating various cellular genes, including the cytokines interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α). Read More

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http://dx.doi.org/10.1089/AID.2018.0115DOI Listing
December 2018
5 Reads

Human T-lymphotropic virus 1 associated with adult T-cell leukemia/lymphoma.

Cutis 2018 Jul;102(1):E4-E7

Integrated Health Associates, Ann Arbor, Michigan, USA.

Adult T-cell leukemia/lymphoma (ATLL) is an uncommon neoplasm of mature T lymphocytes associated with infection by human T-lymphotropic virus 1 (HTLV-1), which is increasing in incidence in areas of the United States with large immigrant populations. Human T-lymphotrophic virus 1 infection is asymptomatic in most patients and has been associated with ATLL as well as tropical spastic paraparesis. Because there is considerable histologic overlap with other cutaneous T-cell lymphomas, high suspicion and clinical features must be present to make the diagnosis of ATLL. Read More

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July 2018
8 Reads

The clinical impact of human T-lymphotrophic virus type 1 (HTLV-1) infection on the development of adult T-cell leukemia-lymphoma (ATL) or HTLV-1-associated myelopathy (HAM) / atypical HAM after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and renal transplantation.

J Clin Exp Hematop 2018 Sep 8;58(3):107-121. Epub 2018 Aug 8.

Because there are limited clinical reports on the impact of human T-lymphotropic virus type 1 (HTLV-1) on organ transplantation, its effects on the development of adult T-cell leukemia-lymphoma (ATL), post-transplantation lymphoproliferative disorder (PTLD) and HTLV-1-associated myelopathy (HAM) or atypical HAM after organ transplantation remain unclear.We retrospectively analyzed the impact of HTLV-1 in 54 allogeneic hematopoietic stem cell transplantation (allo-HSCT) cases and 31 renal transplantation cases between January 2006 and December 2016.Among the 54 allo-HSCT cases, nine recipients with ATL tested positive for HTLV-1, and one was found to be an HTLV-1 carrier. Read More

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http://dx.doi.org/10.3960/jslrt.18011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408177PMC
September 2018
44 Reads

Droplet digital PCR for absolute quantification of proviral load of human T-cell lymphotropic virus (HTLV) types 1 and 2.

J Virol Methods 2018 10 10;260:70-74. Epub 2018 Jul 10.

Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Background: Human T-lymphotrophic virus (HTLV) types 1 and 2 cause lifelong infection whereby most infected individuals are asymptomatic whilst a minority develop infection-related disease. These latter patients invariably have been found to have high proviral load (PVL). Therefore, infected patients are monitored by determining the proportion of lymphocytes that are infected with HTLV-1/2. Read More

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http://dx.doi.org/10.1016/j.jviromet.2018.07.003DOI Listing
October 2018
18 Reads

FOXP3-positive T-cell lymphomas in non-HTLV1 carriers include ALK-negative anaplastic large cell lymphoma: expanding the spectrum of T-cell lymphomas with regulatory phenotype.

Hum Pathol 2018 10 10;80:138-144. Epub 2018 Jun 10.

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

Forkhead box P3 (FOXP3) is a specific marker for regulatory T-cells (Tregs). We report 6 cases of T-cell lymphomas with Treg phenotype based on diffuse positivity for FOXP3 in tumor cells. The patients showed a median age of 56 years with a male predominance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183020
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http://dx.doi.org/10.1016/j.humpath.2018.06.001DOI Listing
October 2018
13 Reads

The Human T-Cell Leukemia Virus Type 1 Basic Leucine Zipper Factor Attenuates Repair of Double-Stranded DNA Breaks via Nonhomologous End Joining.

J Virol 2018 08 17;92(15). Epub 2018 Jul 17.

Brody School of Medicine, Department of Microbiology and Immunology, East Carolina University, Greenville, North Carolina, USA

Adult T-cell leukemia (ATL) is a fatal malignancy of CD4 T cells infected with human T-cell leukemia virus type 1 (HTLV-1). ATL cells often exhibit random gross chromosomal rearrangements that are associated with the induction and improper repair of double-stranded DNA breaks (DSBs). The viral oncoprotein Tax has been reported to impair DSB repair but has not been shown to be consistently expressed throughout all phases of infection. Read More

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http://dx.doi.org/10.1128/JVI.00672-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052317PMC
August 2018
9 Reads

Unexpected donor-derived infectious transmissions by kidney transplantation: A systematic review.

Transpl Infect Dis 2018 Apr 6;20(2):e12851. Epub 2018 Mar 6.

Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, NSW, Australia.

Background: Unexpected donor-derived transmission of infections is rare, but is associated with significant morbidity and mortality. We aimed to provide an overview of published cases on unexpected infectious transmissions.

Methods: We systematically reviewed all published evidence describing any unexpected donor-derived viral, bacterial, fungal, and parasitic infections in kidney transplant recipients. Read More

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http://dx.doi.org/10.1111/tid.12851DOI Listing
April 2018
50 Reads

HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition.

Nat Commun 2018 01 30;9(1):431. Epub 2018 Jan 30.

Laboratory of Biology and Modelling of the Cell, ENS de Lyon, Univ Claude Bernard Lyon 1, CNRS UMR 5239, INSERM U1210, 46 allée d'Italie, 69364, Lyon, France.

Up-Frameshift Suppressor 1 Homolog (UPF1) is a key factor for nonsense-mediated mRNA decay (NMD), a cellular process that can actively degrade mRNAs. Here, we study NMD inhibition during infection by human T-cell lymphotropic virus type I (HTLV-1) and characterise the influence of the retroviral Tax factor on UPF1 activity. Tax interacts with the central helicase core domain of UPF1 and might plug the RNA channel of UPF1, reducing its affinity for nucleic acids. Read More

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http://dx.doi.org/10.1038/s41467-017-02793-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789848PMC
January 2018
30 Reads

Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells.

Proc Natl Acad Sci U S A 2018 02 22;115(6):E1269-E1278. Epub 2018 Jan 22.

Laboratory of Virus Control, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan;

Viruses causing chronic infection artfully manipulate infected cells to enable viral persistence in vivo under the pressure of immunity. Human T-cell leukemia virus type 1 (HTLV-1) establishes persistent infection mainly in CD4+ T cells in vivo and induces leukemia in this subset. HTLV-1-encoded Tax is a critical transactivator of viral replication and a potent oncoprotein, but its significance in pathogenesis remains obscure due to its very low level of expression in vivo. Read More

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http://dx.doi.org/10.1073/pnas.1715724115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819419PMC
February 2018
13 Reads

Interference of HTLV-1 Tax Protein with Cell Polarity Regulators: Defining the Subcellular Localization of the Tax-DLG1 Interaction.

Viruses 2017 11 23;9(12). Epub 2017 Nov 23.

Instituto de Biología Molecular y Celular de Rosario-CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina.

Human T cell leukemia virus (HTLV)-1 Tax (Tax) protein is very important in viral replication and cell transformation. Tax localizes in the nucleus and cytoplasm in association with organelles. Some activities of Tax depend on interactions with PDZ (PSD-95/Discs Large/Z0-1) domain-containing proteins such as Discs large protein 1 (DLG1) which is involved in cell polarity and proliferation. Read More

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http://dx.doi.org/10.3390/v9120355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744130PMC
November 2017
10 Reads

Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphoma.

Leuk Res 2017 10 18;61:18-24. Epub 2017 Aug 18.

Laboratory of Hematoimmunology, Graduate School of Health Sciences, University of the Ryukyus, Nishihara, Japan. Electronic address:

Okinawa, comprising remote islands off the mainland of Japan, is an endemic area of human T-cell leukemia virus type I (HTLV-1), the causative virus of adult T-cell leukemia-lymphoma (ATL) and HTLV-1-associated myelopathy (HAM). We investigated the tax genotype of HTLV-1 among 29 HTLV-1 carriers, 74 ATL patients, and 33 HAM patients in Okinawa. The genotype distribution-60 (44%) taxA cases and 76 (56%) taxB cases-differed from that of a previous report from Kagoshima Prefecture in mainland Japan (taxA, 10%; taxB, 90%). Read More

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http://dx.doi.org/10.1016/j.leukres.2017.08.006DOI Listing
October 2017
125 Reads

Extrafollicular activities: perspectives on HIV infection, germinal center-independent maturation pathways, and KSHV-mediated lymphoproliferation.

Curr Opin Virol 2017 10 3;26:69-73. Epub 2017 Aug 3.

Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, United States. Electronic address:

Early events in the pathogenesis of KSHV-associated lymphoproliferations in the context of HIV disease remain poorly understood. Recent research indicates that latent HIV infection causes persistent immune dysfunction in B cell follicles. Simultaneously, lack of T cell immune surveillance in the lymph nodes dysregulates the biology of EBV. Read More

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http://dx.doi.org/10.1016/j.coviro.2017.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673501PMC
October 2017
7 Reads

Effects of Ascorbic Acid on Tax, NF-κB and MMP-9 in Human T-cell Lymphotropic Virus Type 1 Positive Malignant T-Lymphocytes.

Anticancer Agents Med Chem 2018 ;18(2):237-244

Dr. Rath Research Institute, Santa Clara, CA, United States.

Background: HTLV1 is a retrovirus that infects CD4-positive cells and leads to Adult T-cell leukemia by constitutive activation of nuclear factor kappa B. Ascorbic acid (AA) is an essential nutrient that possess anti-proliferative and pro-apoptotic activity against a number of malignant cell lines. This study delineates the effect of AA on Tax protein expression as well as NF-κB and MMP9 activity in two HTLV1-positive leukemia cells (HuT-102 and C91-PL). Read More

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http://dx.doi.org/10.2174/1871520617666170725160628DOI Listing
July 2019
37 Reads

Hijacking of the O-GlcNAcZYME complex by the HTLV-1 Tax oncoprotein facilitates viral transcription.

PLoS Pathog 2017 Jul 24;13(7):e1006518. Epub 2017 Jul 24.

INSERM, U1016, Institut Cochin, Paris, France.

The viral Tax oncoprotein plays a key role in both Human T-cell lymphotropic virus type 1 (HTLV-1)-replication and HTLV-1-associated pathologies, notably adult T-cell leukemia. Tax governs the transcription from the viral 5'LTR, enhancing thereby its own expression, via the recruitment of dimers of phosphorylated CREB to cAMP-response elements located within the U3 region (vCRE). In addition to phosphorylation, CREB is also the target of O-GlcNAcylation, another reversible post-translational modification involved in a wide range of diseases, including cancers. Read More

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http://dx.doi.org/10.1371/journal.ppat.1006518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542696PMC
July 2017
28 Reads

A Unique T-Cell Receptor Amino Acid Sequence Selected by Human T-Cell Lymphotropic Virus Type 1 Tax-Specific Cytotoxic T Cells in HLA-A24:02-Positive Asymptomatic Carriers and Adult T-Cell Leukemia/Lymphoma Patients.

J Virol 2017 10 12;91(19). Epub 2017 Sep 12.

Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan

We previously reported that the T-cell receptor (TCR) repertoire of human T-cell lymphotropic virus type 1 (HTLV-1) Tax-specific CD8 cytotoxic T cells (Tax-CTLs) was highly restricted and a particular amino acid sequence motif, the PDR motif, was conserved among HLA-A*24:02-positive (HLA-A*24:02) adult T-cell leukemia/lymphoma (ATL) patients who had undergone allogeneic hematopoietic cell transplantation (allo-HSCT). Furthermore, we found that donor-derived PDR CTLs selectively expanded in ATL long-term HSCT survivors with strong CTL activity against HTLV-1. On the other hand, the TCR repertoires in Tax-CTLs of asymptomatic HTLV-1 carriers (ACs) remain unclear. Read More

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http://dx.doi.org/10.1128/JVI.00974-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599769PMC
October 2017
37 Reads

HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation.

Nat Commun 2017 06 22;8:15890. Epub 2017 Jun 22.

Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département de Virologie, Institut Pasteur, Paris F-75015, France.

The human T-lymphotropic virus type 1 (HTLV-1) is efficiently transmitted through cellular contacts. While the molecular mechanisms of viral cell-to-cell propagation have been extensively studied in vitro, those facilitating the encounter between infected and target cells remain unknown. In this study, we demonstrate that HTLV-1-infected CD4 T cells secrete a potent chemoattractant, leukotriene B4 (LTB4). Read More

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http://dx.doi.org/10.1038/ncomms15890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489682PMC
June 2017
53 Reads

Expression of HTLV-1 Genes in T-Cells Using RNA Electroporation.

Methods Mol Biol 2017 ;1582:155-170

Department of Surgery, Oncology and Gastroenterology, University of Padova, Via Gattamelata 64, Padova, 35128, Italy.

Human T-cell leukemia virus type 1 (HTLV-1) infects about 20 million people world-wide. Around 5% of the infected individuals develop adult T-cell leukemia (ATL) or a neurological disease termed tropical spastic paraparesis (TSP) after a clinical latency of years to decades. Through the use of two promoters and alternative splicing HTLV-1 expresses at least 12 different proteins. Read More

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http://dx.doi.org/10.1007/978-1-4939-6872-5_12DOI Listing
February 2018
14 Reads

Methods for Identifying and Examining HTLV-1 HBZ Post-translational Modifications.

Methods Mol Biol 2017 ;1582:111-126

Center for Retrovirus Research, The Ohio State University, Columbus, OH, 43210, USA.

Post-translational modifications (PTMs) are chemical alterations to individual amino acids that alter a protein's conformation, stability, and/or function. Several pathogenic viruses have been shown to encode proteins with PTMs, including human T-cell leukemia virus type 1 (HTLV-1) Tax and Rex regulatory proteins. HTLV-1 basic leucine zipper protein (HBZ) was hypothesized to feature PTMs due to its functional activities and interactions with cellular transcription factors and acetyltransferases. Read More

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http://dx.doi.org/10.1007/978-1-4939-6872-5_9DOI Listing
February 2018
24 Reads

Quantitative Analysis of Human T-Lymphotropic Virus Type 1 (HTLV-1) Infection Using Co-Culture with Jurkat LTR-Luciferase or Jurkat LTR-GFP Reporter Cells.

Methods Mol Biol 2017 ;1582:47-55

Equipe Oncogenèse Rétrovirale, Lyon, 69364 Cedex, 07, France.

Unlike HIV-1, HTLV-1 viral transmission requires cell-to-cell contacts, while cell-free virions are poorly infectious and almost absent from body fluids. Though the virus uses three nonexclusive mechanisms to infect new target cells: (1) MTOC polarization followed by formation of a virological synapse and viral transfer into a synaptic cleft, (2) genesis of a viral biofilm and its transfer of embedded viruses, or (3) HTLV-1 transmission using conduits. The Tax transactivator and the p8 viral proteins are involved in virological synapse and nanotube formation respectively. Read More

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http://dx.doi.org/10.1007/978-1-4939-6872-5_4DOI Listing
February 2018
8 Reads

An Autopsy Case Report of Adult T-cell Leukemia Accompanied by Rheumatoid Arthritis Mimicking Diffuse Panbronchiolitis.

J UOEH 2017 ;39(1):55-61

Department of Respiratory Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

A 50-year-old female with a history of chronic sinusitis and rheumatoid arthritis visited our department with repetitive lower respiratory tract infections of Pseudomonas aeruginosa. Her chest CT showed diffuse panbronchiolitis-like pulmonary lesions, her blood examination revealed atypical lymphocytes, and she was serologically positive for anti-human T-lymphotrophic virus type 1 (HTLV-1) antibody. Her rheumatoid arthritis had been well-controlled after biological agent treatment followed by anti-inflammatory analgesic treatment. Read More

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http://dx.doi.org/10.7888/juoeh.39.55DOI Listing
June 2017
27 Reads

Effects of expressing human T-cell leukemia virus type 1 (HTLV-I) oncoprotein Tax on DOK1, DOK2 and DOK3 gene expression in mice.

Authors:
Takeo Ohsugi

J Vet Med Sci 2017 May 12;79(5):935-938. Epub 2017 Mar 12.

Department of Laboratory Animal Science, School of Veterinary Medicine, Rakuno-Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan.

Transgenic mice expressing the tax gene from human T-cell leukemia virus type 1 (HTLV-I) genome developed T-cell leukemia or histiocytic sarcoma after at least 12 months. The transgenic mice showed low expression of the downstream of tyrosine kinase (DOK) family members, DOK1, DOK2 and DOK3, which were recently reported to be tumor suppressor genes. Mice showed low DOK2 expression at 5-6 months of age, before disease onset. Read More

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http://dx.doi.org/10.1292/jvms.17-0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447985PMC
May 2017
6 Reads

HTLV-1 Tax activates HIV-1 transcription in latency models.

Virology 2017 04 30;504:45-51. Epub 2017 Jan 30.

Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil. Electronic address:

HIV-1 latency is a major obstacle to HIV-1 eradication. Coinfection with HTLV-1 has been associated with faster progression to AIDS. HTLV-1 encodes the transactivator Tax which can activate both HTLV-1 and HIV-1 transcription. Read More

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http://dx.doi.org/10.1016/j.virol.2017.01.014DOI Listing
April 2017
43 Reads

Seroprevalence and geographical distribution of human T-lymphotropic virus type 1 among volunteer blood donors in endemic areas of Iran.

Virol J 2017 01 30;14(1):14. Epub 2017 Jan 30.

Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Hemmat Exp. Way, Next to the Milad Tower, Tehran, Iran.

Background: Human T-cell lymphotrophic virus type 1 (HTLV-1) has a worldwide distribution and it is endemic in some regions of Iran. One of the most important routes of HTLV-1 transmission is via transfusion of contaminated blood components. The risk of transmission through asymptomatic blood donors, particularly in endemic areas should be considered and appropriately managed. Read More

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http://dx.doi.org/10.1186/s12985-017-0693-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282699PMC
January 2017
18 Reads

The sense behind retroviral anti-sense transcription.

Virol J 2017 01 14;14(1). Epub 2017 Jan 14.

Department of Immunology, University of Manitoba, Winnipeg, MB, Canada.

Retroviruses are known to rely extensively on the expression of viral proteins from the sense proviral genomic strand. Yet, the production of regulatory retroviral proteins from antisense-encoded viral genes is gaining research attention, due to their clinical significance. This report will discuss what is known about antisense transcription in Retroviridae, and provide new information about antisense transcriptional regulation through a comparison of Human Immunodeficiency Virus (HIV), Human T-cell Lymphotrophic Virus (HTLV-1) and endogenous retrovirus-K (ERVK) long terminal repeats (LTRs). Read More

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http://dx.doi.org/10.1186/s12985-016-0667-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237517PMC
January 2017
46 Reads

An Update on the Global Epidemic of Human T-Cell Lymphotrophic Virus Type-I (HTLV-I).

J Long Term Eff Med Implants 2017 ;27(2-4):355-368

Harvard Medical School, Boston, Massachusetts.

Infection with human T-cell lymphotrophic virus-I (HTLV-I) is now a global epidemic, affecting 10 to 20 million people. This virus has been linked to life-threatening, incurable diseases, adult T-cell leukemia/lymphoma (ATLL), and HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), as well as several chronic illnesses, such as uveitis and dermatitis. The cumulative lifetime risk of developing these incurable diseases is approximately 5% in asymptomatic patients. Read More

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http://dx.doi.org/10.1615/JLongTermEffMedImplants.v27.i2-4.160DOI Listing
July 2019
7 Reads

HTLV-1 Tax-Specific CTL Epitope-Pulsed Dendritic Cell Therapy Reduces Proviral Load in Infected Rats with Immune Tolerance against Tax.

J Immunol 2017 02 23;198(3):1210-1219. Epub 2016 Dec 23.

Department of Immunotherapeutics, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.

Adult T cell leukemia/lymphoma (ATL), a CD4 T cell malignancy with a poor prognosis, is caused by human T cell leukemia virus type 1 (HTLV-1) infection. High proviral load (PVL) is a risk factor for the progression to ATL. We previously reported that some asymptomatic carriers had severely reduced functions of CTLs against HTLV-1 Tax, the major target Ag. Read More

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http://dx.doi.org/10.4049/jimmunol.1601557DOI Listing
February 2017
28 Reads

Role of the HTLV-1 viral factors in the induction of apoptosis.

Biomed Pharmacother 2017 Jan 23;85:334-347. Epub 2016 Nov 23.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Adult T-cell leukemia (ATL) and HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) are the two main diseases that are caused by the HTLV-1 virus. One of the features of HTLV-1 infection is its resistance against programmed cell death, which maintains the survival of cells to oncogenic transformation and underlies the viruses' therapeutic resistance. Two main genes by which the virus develops cancer are Tax and HBZ; playing an essential role in angiogenesis in regulating viral transcription and modulating multiple host factors as well as apoptosis pathways. Read More

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http://dx.doi.org/10.1016/j.biopha.2016.11.034DOI Listing
January 2017
16 Reads

Dysregulation of c-Myb Pathway by Aberrant Expression of Proto-oncogene MYB Provides the Basis for Malignancy in Adult T-cell Leukemia/lymphoma Cells.

Clin Cancer Res 2016 Dec 15;22(23):5915-5928. Epub 2016 Jun 15.

Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.

Purpose: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive human T-cell malignancy induced by human T-lymphotrophic virus-1 (HTLV-1) infection. The genetic alterations in infected cells that lead to transformation have not been completely elucidated, thus hindering the identification of effective therapeutic targets for ATL. Here, we present the first assessment of MYB proto-oncogene dysregulation in ATL and an exploration of its role in the onset of ATL. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1739DOI Listing
December 2016
26 Reads

The Tax-Inducible Actin-Bundling Protein Fascin Is Crucial for Release and Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1 (HTLV-1).

PLoS Pathog 2016 Oct 24;12(10):e1005916. Epub 2016 Oct 24.

Institute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

The delta-retrovirus Human T-cell leukemia virus type 1 (HTLV-1) preferentially infects CD4+ T-cells via cell-to-cell transmission. Viruses are transmitted by polarized budding and by transfer of viral biofilms at the virological synapse (VS). Formation of the VS requires the viral Tax protein and polarization of the host cytoskeleton, however, molecular mechanisms of HTLV-1 cell-to-cell transmission remain incompletely understood. Read More

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http://dx.doi.org/10.1371/journal.ppat.1005916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077169PMC
October 2016
61 Reads

Not the Usual Viral Suspects: Parvovirus B19, West Nile Virus, and Human T-Cell Lymphotrophic Virus Infections After Kidney Transplantation.

Semin Nephrol 2016 09;36(5):428-434

Division of Infectious Diseases and the William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN. Electronic address:

Kidney transplant recipients are at increased risk of developing clinical disease due to uncommon opportunistic viral pathogens. Refractory anemia is classically associated with parvovirus B19 infection. West Nile virus has the propensity to cause fever and neurologic symptoms, while spastic paresis and lymphoma can be triggered by human T cell lymphotrophic virus. Read More

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http://dx.doi.org/10.1016/j.semnephrol.2016.05.019DOI Listing
September 2016
19 Reads

HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma-A Tale of Two Proteins: Tax and HBZ.

Viruses 2016 06 16;8(6). Epub 2016 Jun 16.

Department of Microbiology and Molecular Cell Biology, The Leroy T. Canoles Jr Cancer Research Center, Eastern Virginia Medical School, Norfolk, VA 23501, USA.

HTLV-1 (Human T-cell lymphotropic virus type 1) is a complex human delta retrovirus that currently infects 10-20 million people worldwide. While HTLV-1 infection is generally asymptomatic, 3%-5% of infected individuals develop a highly malignant and intractable T-cell neoplasm known as adult T-cell leukemia/lymphoma (ATL) decades after infection. How HTLV-1 infection progresses to ATL is not well understood. Read More

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http://dx.doi.org/10.3390/v8060161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926181PMC
June 2016
13 Reads

Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells.

Acta Virol 2016 Jun;60(2):211-3

Human T-cell leukemia virus type 1 (HTLV-1) can cause an aggressive malignancy known as adult T-cell leukemia/lymphoma (ATLL). The Tax protein encoded by the pX region of the HTLV-1 genome appears to be a key element in the early stage of ATLL development. In this study, we examined the expression of the downstream of tyrosine kinase (DOK) family members DOK1, DOK2 and DOK3, recently reported to be tumor suppressors, in HTLV-1-transformed T cells (MT-2 and HUT-102) and TL-Om1 cells derived from ATLL leukemic cells. Read More

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http://dx.doi.org/10.4149/av_2016_02_211DOI Listing
June 2016
7 Reads

Human T-Lymphotropic Virus Type 1-Induced Overexpression of Activated Leukocyte Cell Adhesion Molecule (ALCAM) Facilitates Trafficking of Infected Lymphocytes through the Blood-Brain Barrier.

J Virol 2016 08 27;90(16):7303-7312. Epub 2016 Jul 27.

Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département de Virologie, Institut Pasteur, Paris, France

Unlabelled: Human T-lymphotropic virus type 1 (HTLV-1) is the etiological agent of a slowly progressive neurodegenerative disease, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). This disease develops upon infiltration of HTLV-1-infected lymphocytes into the central nervous system, mostly the thoracic spinal cord. The central nervous system is normally protected by a physiological structure called the blood-brain barrier (BBB), which consists primarily of a continuous endothelium with tight junctions. Read More

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http://dx.doi.org/10.1128/JVI.00539-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984663PMC
August 2016
124 Reads

Viral oncomiR spreading between B and T cells is employed by Kaposi's sarcoma herpesvirus to induce non-cell-autonomous target gene regulation.

Oncotarget 2016 Jul;7(27):41870-41884

Sheba Cancer Research Center, Chaim Sheba Academic Medical Center, Tel Hashomer, Ramat Gan 5262100, Israel.

The two human lymphotrophic γ-herpesviruses, Kaposi's sarcoma herpesvirus (KSHV) and Epstein-Barr virus (EBV), are a recognized cause of human cancer, encoding multiple miRs that are major players in carcinogenesis. Previously, we discovered that EBV-encoded miRs transfer between infected B and T lymphocytes. To further explore the biological significance of the spreading of γ-herpesvirus-encoded miRs on carcinogenesis, we focused on KSHV-miR-K12-11 (miR-K12-11) that is unique in having an identical seed sequence with the oncomiR hsa-miR-155, implicated in B cell lymphomas development. Read More

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http://dx.doi.org/10.18632/oncotarget.9627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173102PMC
July 2016
67 Reads

Historical review of the causes of cancer.

World J Clin Oncol 2016 Feb;7(1):54-86

Clarke Brian Blackadar, Department of Food Science, Ontario Agricultural College, University of Guelph, Guelph, ON N1G 2W1, Canada.

In the early 1900s, numerous seminal publications reported that high rates of cancer occurred in certain occupations. During this period, work with infectious agents produced only meager results which seemed irrelevant to humans. Then in the 1980s ground breaking evidence began to emerge that a variety of viruses also cause cancer in humans. Read More

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http://dx.doi.org/10.5306/wjco.v7.i1.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734938PMC
February 2016
8 Reads

The Major Histocompatibility Complex Class II Transactivator CIITA Inhibits the Persistent Activation of NF-κB by the Human T Cell Lymphotropic Virus Type 1 Tax-1 Oncoprotein.

J Virol 2016 Jan 20;90(7):3708-21. Epub 2016 Jan 20.

General Pathology and Immunology Laboratory, Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy

Unlabelled: Human T cell lymphotropic virus type 1 (HTLV-1) Tax-1, a key protein in HTLV-1-induced T cell transformation, deregulates diverse cell signaling pathways. Among them, the NF-κB pathway is constitutively activated by Tax-1, which binds to NF-κB proteins and activates the IκB kinase (IKK). Upon phosphorylation-dependent IκB degradation, NF-κB migrates into the nucleus, mediating Tax-1-stimulated gene expression. Read More

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http://dx.doi.org/10.1128/JVI.03000-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794681PMC
January 2016
12 Reads

Polycomb-dependent epigenetic landscape in adult T-cell leukemia.

Blood 2016 Apr 15;127(14):1790-802. Epub 2016 Jan 15.

Graduate School of Frontier Sciences, Department of Computational Biology and Medical Sciences, and.

Adult T-cell leukemia-lymphoma (ATL) shows global gene expression alterations that confer cellular characteristics and unfavorable prognosis. However, molecular mechanisms of the sustained expression changes are largely unknown, because there is no study addressing the relationship between landscapes of the gene expression and epigenetic modifications. Here, we analyzed ATL epigenome and integrated it with transcriptome from primary ATL cells and those from corresponding normal CD4(+)T cells to decipher ATL-specific "epigenetic code" that was critical for cell identity. Read More

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http://www.bloodjournal.org/content/early/2016/01/15/blood-2
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-08-66
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http://dx.doi.org/10.1182/blood-2015-08-662593DOI Listing
April 2016
54 Reads