10,522 results match your criteria Human Pathology [Journal]


MDM2 copy number increase: A poor prognostic, molecular event in esophageal squamous cell carcinoma.

Hum Pathol 2019 Apr 17. Epub 2019 Apr 17.

Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan; Institute of Liver Studies, King's College Hospital, London, UK. Electronic address:

The present study aimed to elucidate the clinicopathological significance of molecular alterations in MDM2 in esophageal squamous cell carcinoma (ESCC). A total of 399 resected cases of ESCC were examined by dual-color in situ hybridization (DISH) for MDM2 and immunohistochemistry for p53 using tissue microarrays. Clinicopathological features were correlated with the MDM2 status. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.04.002DOI Listing

Stromal inflammatory cells are associated with poorer prognosis in primary cutaneous melanoma.

Hum Pathol 2019 Apr 6. Epub 2019 Apr 6.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

We observed that non-tumor infiltrating inflammatory cells are often present in the stroma of melanoma. The role of these stromal inflammatory cells (SIC) in cancer has not been studied. We evaluated the prognostic significance of SIC in 299 patients with vertical growth phase primary melanomas with at least 10years of clinical follow-up. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.03.008DOI Listing
April 2019
1 Read

Gastric hepatoid adenocarcinomas are a genetically heterogenous group; most tumors show ‘chromosomal instability,’ but ‘MSI’ tumors do exist.

Hum Pathol 2019 Apr 1. Epub 2019 Apr 1.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:

The Cancer Genome Atlas Research Network classified gastric adenocarcinoma into four molecular subtypes: (1) Epstein-Barr virus-positive (EBV), (2) microsatellite-instable (MSI), (3) chromosomal instability (CIN), and (4) genomically stable (GS). The molecular subtypes of gastric hepatoid adenocarcinomas are still largely unknown. We analyzed 52 hepatoid adenocarcinomas for the expression of surrogate markers of molecular subtypes (MLH1, p53, and EBER in situ hybridization) and some biomarkers (p21, p16, Rb, cyclin D1, cyclin E, β-catenin, Bcl-2, IMP3, ARID1A and HER2), and mutations of TP53, CTNNB1, KRAS, and BRAF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177193005
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http://dx.doi.org/10.1016/j.humpath.2019.03.006DOI Listing
April 2019
3 Reads

Fibro-osseous Pseudotumor of digits and myositis Ossificans show consistent COL1A1-USP6 rearrangement: a Clinicopathological and genetic study of 27 cases.

Hum Pathol 2019 Apr 1. Epub 2019 Apr 1.

Šikl's Department of Pathology, Charles University in Prague, The Faculty of Medicine and Faculty Hospital in Pilsen, Alej Svobody 80, 304 60 Pilsen, Czech Republic; Bioptická laboratoř s.r.o., Mikulášske nám. 4, 326 00, Pilsen.

Myositis ossificans (MO) and fibro-osseous pseudotumor of digits (FOPD) are localized, self-limiting bone-producing pseudosarcomatous lesions characterized by nodular fasciitis-like proliferation and osteoid and immature woven bone production, which may eventually develop into more mature lamelar bone. Traditionally, MO/FOPD were thought to be of reactive, non-neoplastic nature. USP6 gene rearrangement was recently reported as a consistent finding in MO and FOPD, thus expanding the spectrum of transient, USP6-rearranged neoplasms. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.02.009DOI Listing
April 2019
2 Reads

Follicular cholecystitis: Clinicopathologic associations.

Hum Pathol 2019 Apr 1. Epub 2019 Apr 1.

Department of Pathology and Immunology, School of Medicine, Washington University in St. Louis, 425 S Euclid Ave, Campus Box 8118, St. Louis, MO, USA 63110.. Electronic address:

Follicular cholecystitis (FC) is a relatively rare entity with uncertain causal associations. In this study, we aimed to explore different clinicopathologic associations of FC, and to better characterize the entity. A retrospective review of archival H&E slides and pertinent clinical information was undertaken for all cholecystectomy cases with a rendered diagnosis of "follicular cholecystitis", from 1991 to 2017. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.03.003DOI Listing
April 2019
3 Reads

A comparison of adult rhabdomyosarcoma and high grade neuroendocrine carcinoma of the urinary bladder reveals novel PPP1R12A fusions in rhabdomyosarcoma.

Hum Pathol 2019 Apr 1. Epub 2019 Apr 1.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, US. Electronic address:

Some rhabdomyosarcomas and sarcomatoid carcinomas with heterologous rhabdomyosarcomatous elements resemble high-grade neuroendocrine carcinoma, creating a diagnostic difficulty. The purpose of this study was to characterize the overlap of adult genitourinary rhabdomyosarcomas, excluding those occurring at paratesticular sites, with high-grade neuroendocrine carcinoma and identify features helpful in their separation. Seventeen cases of rhabdomyosarcoma (eleven from the urinary bladder and three each from kidney and prostate) were compared to ten cases of high-grade neuroendocrine carcinoma from the urinary bladder. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177193005
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http://dx.doi.org/10.1016/j.humpath.2019.03.007DOI Listing
April 2019
11 Reads

The repertoire of genetic alterations in salivary duct carcinoma including a novel HNRNPH3-ALK rearrangement.

Hum Pathol 2019 Apr 1. Epub 2019 Apr 1.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Salivary duct carcinoma (SDC) is a rare, aggressive malignancy with limited treatment options and poor outcome. Twenty-nine primary resected SDC, including 15 SDC de novo (SDCDN), and 14 SDC ex pleomorphic adenoma (SDCXPA) were subjected to the massive parallel sequencing assay (MSK-IMPACT™) targeting 287-468 cancer-related genes. TP53 was the most frequently altered gene (69%). Read More

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http://dx.doi.org/10.1016/j.humpath.2019.03.004DOI Listing
April 2019
3 Reads

Frequent loss of heterozygosity of SMAD4 locus and prognostic impacts of SMAD4 immunohistochemistry in gastric adenocarcinoma with enteroblastic differentiation.

Hum Pathol 2019 Apr 1. Epub 2019 Apr 1.

Department of Human Pathology, Juntendo University, Graduate School of Medicine, Tokyo, 113-8421, Japan.

Gastric adenocarcinoma with enteroblastic differentiation (GAED) is a rare variant of gastric adenocarcinoma. Clinicopathologically, GAED is known to be aggressive and is characterized by frequent vascular invasion, lymphatic invasion, and liver metastasis even in early stages. SMAD4 was identified as a frequently deleted gene in GAED by copy number variation analysis in our previous next-generation sequencing study; therefore, we examined the clinicopathological impacts of SMAD4 in 51 cases of GAEDs (early: 17, advanced: 34). Read More

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http://dx.doi.org/10.1016/j.humpath.2019.03.005DOI Listing
April 2019
1 Read

Epstein–Barr virus (EBV) incidental expression in bone marrow cells, a study of 230 consecutive bone marrow biopsy samples.

Hum Pathol 2019 Apr 1. Epub 2019 Apr 1.

Department of Pathology and Laboratory Medicine, University of California Irvine (UCI) Medical Center, Orange. Electronic address:

Epstein-Barr virus (EBV) is associated with many neoplastic hematologic conditions, but scattered EBV positive cells can be detected in lymph nodes of healthy individuals and they usually represent latently infected lymphocytes. The incidence of EBV detection in normal bone marrow samples has not been studied and is largely unknown. The lack of knowledge regarding the true incidence of encountering bystander latent EBV-positive cells in the bone marrow may potentially lead to a diagnostic dilemma when assessing a staging bone marrow for a patient with an EBV-positive B or T/NK-cell lymphoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177193005
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http://dx.doi.org/10.1016/j.humpath.2018.11.034DOI Listing
April 2019
2 Reads

Identification of key challenges in liver pathology: data from a multicenter study of extramural consults.

Hum Pathol 2019 Mar 8. Epub 2019 Mar 8.

Department of Pathology, University of Washington Medical Center, Seattle, WA, USA.

Extramural consultation for challenging pathology cases is an important part of patient care. The specific reasons why liver cases are submitted in consultation are poorly understood. To study patterns in extramural consultation, data were gathered from 1360 liver/GI/pancreatobiliary consults submitted to 7 academic centers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177193003
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http://dx.doi.org/10.1016/j.humpath.2019.03.001DOI Listing
March 2019
5 Reads

Fusion of ALK to the melanophilin gene MLPH in pediatric Spitz nevi.

Hum Pathol 2019 Mar 8. Epub 2019 Mar 8.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

Spitzoid neoplasms typically affect young individuals and include Spitz nevus, atypical Spitz tumor and Spitzoid melanoma. Spitz tumors can exhibit gene fusions involving the receptor tyrosine kinases NTRK1, NTRK3, ALK, ROS1, RET, or MET, or, the serine-threonine kinase BRAF. Since most studies have been based on adult cases, we studied ALK fusions in Spitz nevi occurring in pediatric patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177193003
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http://dx.doi.org/10.1016/j.humpath.2019.03.002DOI Listing
March 2019
6 Reads

TP53 missense mutation is associated with increased tumor-infiltrating T-cells in primary prostate Cancer.

Hum Pathol 2019 Mar 6. Epub 2019 Mar 6.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, United States; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, United States; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, United States.

The makeup of the tumor immune microenvironment may be associated with tumor somatic genomic alterations and plays a key role in tumor progression and response to immunotherapy. We examined the association of tumor-infiltrating T-cell density with TP53 status in surgically treated primary prostate cancer using 3 independent tissue microarray sets, including one set of tumors from grade-matched patients of European-American or African-American ancestry (n=391), a retrospective case-cohort of intermediate and high risk patients enriched for adverse outcomes (n=267), and a set of tumors with primary Gleason pattern 5 (n=77). The presence of TP53 missense mutation, indicated by p53 nuclear accumulation using a genetically validated assay, was significantly associated with increased CD3+ T-cell density (median 341 vs. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.02.006DOI Listing

Targeted next-generation sequencing of well-differentiated rectal, gastric, and appendiceal neuroendocrine tumors to identify potential targets.

Hum Pathol 2019 Mar 6. Epub 2019 Mar 6.

Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Gyeonggi-do, Republic of Korea.

Rectal neuroendocrine tumors (NETs) are the most common gastrointestinal (GI) NETs with an uncertain malignant potential despite their small size. There are limited data about driver mutations in rectal NETs, which may explain the tumors' unexpected behavior or common histologic morphology with other GI-NETs. Here, we investigated the clinically and pathologically relevant mutations of rectal and non-rectal NETs and compared the frequency and clinical significance of detected mutations between them. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.02.007DOI Listing
March 2019
1 Read

Immunohistochemistry for TFE3 lacks specificity and sensitivity in the diagnosis of TFE3-rearranged neoplasms: a comparative, two-laboratory study.

Hum Pathol 2019 Mar 6. Epub 2019 Mar 6.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address:

TFE3 rearrangements are characteristic of alveolar soft part sarcomas (ASPS), Xp11.2 translocation renal cell carcinomas (Xp11-RCC), and other rare tumors. Immunohistochemistry for TFE3 protein has been considered by some to be a reliable surrogate for TFE3 molecular studies, although others disagree. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.02.008DOI Listing
March 2019
2 Reads

Perinephric Myxoid Pseudotumor of Fat: A Distinctive Pseudoneoplasm Most Often Associated with Non-neoplastic Renal Disease.

Hum Pathol 2019 Feb 28. Epub 2019 Feb 28.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. Electronic address:

In 2009, Tanas et al reported unusual changes in the perinephric fat, mimicking well-differentiated liposarcoma. We report 11 perinephric masses showing similar changes but chiefly arising in patients with non-neoplastic renal disease. Tissue from 11 perinephric masses was retrieved, and immunohistochemistry for IgG/IgG4 and fluorescence in situ hybridization (FISH) for MDM2 amplification was performed. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.02.005DOI Listing
February 2019
2 Reads

Acute (gangrenous) esophageal necrosis (black esophagus).: A rare form of injury with specific histologic features and diverse clinical associations with a common pathogenesis.

Hum Pathol 2019 Feb 27. Epub 2019 Feb 27.

Unidad de Patología, Hospital General de Mexico, Mexico City, Mexico.

Acute esophageal necrosis (AEN) also known as black esophagus is a rare form of injury to the esophageal mucosa that complicates a variety of clinical conditions. It is characterized by circumpherential black discoloration of the mucosa. There is little information relating to the histopathologic features and pathogenesis of this condition. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.02.003DOI Listing
February 2019

MDM2 amplification and immunohistochemical expression in sarcomatoid renal cell carcinoma.

Hum Pathol 2019 Feb 27. Epub 2019 Feb 27.

Beth, Israel, Deaconess Medical Center, Department of Pathology, Harvard Medical School, Boston, MA, 02215.

The sarcomatoid variant of renal cell carcinoma is a highly aggressive tumor with propensity for metastasis and limited therapeutic options. Metastases of sarcomatoid renal cell carcinoma can sometimes be mistaken for a variety of spindle cell sarcomas, particularly at soft tissue sites in the absence of a history of a kidney tumor. Immunoreactivity for markers associated with certain types of soft tissue sarcomas can, therefore, pose a pitfall for diagnosis under such circumstances. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177193002
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http://dx.doi.org/10.1016/j.humpath.2019.02.004DOI Listing
February 2019
6 Reads

About concomitant KRAS and other molecular alterations in non-small cell lung cancers.

Hum Pathol 2019 Feb 20. Epub 2019 Feb 20.

CHRU Brest, Service d'anatomie et cytologie pathologiques, Brest, F-29200, France; Inserm U1053 BaRITOn, Bordeaux, F-33076, France. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2019.01.003DOI Listing
February 2019

Co-expression of cytokeratin and vimentin in colorectal Cancer highlights a subset of tumor buds and an atypical Cancer-associated stroma.

Hum Pathol 2019 Feb 19. Epub 2019 Feb 19.

Institute of Pathology, University of Bern, Murtenstrasse 31, Bern, CH-3008. Electronic address:

Tumor buds in colorectal cancer are hypothesized to undergo a (partial) epithelial-mesenchymal transition (EMT). If so, Cytokeratin (CK) and Vimentin (VIM) co-expression is expected. CK+/VIM+ can also be found in some stromal cells, however their origin remains unclear. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.02.002DOI Listing
February 2019

FAM134B promotes esophageal squamous cell carcinoma in vitro and its correlations with clinicopathologic features.

Hum Pathol 2019 Feb 19. Epub 2019 Feb 19.

Department of Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, Australia. Electronic address:

Family with sequence similarity 134, member B (FAM134B) is an autophagy regulator of endoplasmic reticulum first discovered to be involved in the pathogenesis of esophageal squamous cell carcinoma (ESCC). The present study examined the functional behavior of FAM134B in cancer cells and the association of FAM134B expression with clinicopathologic factors in patients with ESCC. Expression at both the mRNA and protein levels was investigated using real-time polymerase chain reaction and immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.033DOI Listing
February 2019
2 Reads

Tumor PD-L1 expression in malignant pleural and peritoneal mesothelioma by Dako PD-L1 22C3 pharmDx and Dako PD-L1 28-8 pharmDx assays.

Hum Pathol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pathology, University of Utah, 1950 Circle of Hope, Salt Lake City, UT 84112; ARUP Laboratories, 500 Chipeta Way, Salt Lake City, UT, 84108.

Malignant mesothelioma (MM) is an aggressive neoplasm with poor prognosis. The Dako PD-L1 22C3 and 28-8 pharmDx assays are approved by the US Food and Drug Administration (FDA) as companion and complementary diagnostics for the anti-PD-1 drugs pembrolizumab and nivolumab, respectively. Data from multiple clinical trials indicate that immunotherapy has anti-tumor activity in advanced malignant pleural (MPM) and peritoneal mesothelioma (MPeM). Read More

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http://dx.doi.org/10.1016/j.humpath.2019.02.001DOI Listing
February 2019
1 Read

TPL2, a therapeutic potential target for cancer.

Hum Pathol 2019 Jan 6;83:224. Epub 2018 Jul 6.

The First Affiliated Hospital of Anhui University of Chinese Medicine, 230031, Hefei, Anhui Province, China.

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http://dx.doi.org/10.1016/j.humpath.2018.05.028DOI Listing
January 2019

TEMPORARY REMOVAL: “Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, Serrated and MSI Colorectal Neoplasia”.

Hum Pathol 2019 Feb 2. Epub 2019 Feb 2.

Department of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2018.11.032DOI Listing
February 2019
4 Reads

Incidental nonneoplastic parenchymal findings in patients undergoing lung resection for mass lesions.

Hum Pathol 2019 Apr 15;86:93-101. Epub 2019 Jan 15.

Department of Pathology, Brigham and Women's Hospital, Boston, MA, 02115. Electronic address:

The prevalence of incidental nonneoplastic lung disease in patients undergoing resection for mass lesions is unknown. We determined the prevalence and characteristics of parenchymal findings in patients with lung nodules, aiming to increase awareness of findings that could potentially impact patient management. A total of 397 patients with benign or malignant mass lesions with available presurgical chest computed tomography scans resected between January 2001 and July 2015 were included. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.01.002DOI Listing
April 2019
14 Reads

Myositis ossificans mimicking metaplastic breast cancer on core needle biopsy.

Hum Pathol 2019 Jan 11. Epub 2019 Jan 11.

Institute of Pathology Recklinghausen, University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.

Myositis ossificans (MO) is an uncommon myofibroblastic proliferation that may closely mimic sarcoma. A 33-year old woman presented with a 2-cm breast mass. A core needle biopsy showed highly cellular spindle cell proliferations with atypia and high proliferation activity. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.12.008DOI Listing
January 2019
2 Reads

GATA6: a new predictor for prognosis in ovarian cancer.

Hum Pathol 2019 Apr 8;86:163-169. Epub 2019 Jan 8.

Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA 77030. Electronic address:

Ovarian cancer (OC) is the main cause of gynecological cancer-associated mortality. Improving the diagnosis is important for guiding clinical treatment. The present study aimed to investigate the relationship between expression of GATA6, a stem cell factor, and its prognosis in OC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177193000
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http://dx.doi.org/10.1016/j.humpath.2019.01.001DOI Listing
April 2019
6 Reads

PD-L1 and CD8 are associated with deficient mismatch repair status in triple-negative and HER2-positive breast cancers.

Hum Pathol 2019 Apr 8;86:108-114. Epub 2019 Jan 8.

Department of Pathology, Wexner Medical Center at The Ohio State University, Columbus, OH 43210. Electronic address:

Triple-negative and HER2-positive breast cancers (BCs) are more aggressive than hormone receptor-positive/HER2-negative BCs and show higher levels of tumor-infiltrating lymphocytes (TILs) and PD-L1 expression. Recently, US Food and Drug Administration approved anti-PD-L1 immunotherapy for solid tumors with deficient mismatch repair (MMR). In this study, we aimed to examine the prevalence of deficient MMR and its association with checkpoint immune markers in BCs. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.12.007DOI Listing
April 2019
11 Reads

New fusion sarcomas: histopathology and clinical significance of selected entities.

Hum Pathol 2019 Apr 8;86:57-65. Epub 2019 Jan 8.

Laboratory of Pathology, National Cancer Institute, Bethesda 20892, MD.

Many sarcomas contain gene fusions that can be pathogenetic mechanisms and diagnostic markers. In this article we review selected fusion sarcomas and techniques for their detection. CIC-DUX4 fusion sarcoma is a round cell tumor now considered an entity separate from Ewing sarcoma with a more aggressive clinical course, occurrence in older age, and predilection to soft tissues. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.12.006DOI Listing
April 2019
18 Reads

Hepatic mast cell concentration directly correlates to stage of fibrosis in NASH.

Hum Pathol 2019 Apr 28;86:129-135. Epub 2018 Dec 28.

Pinnacle Clinical Research, San Antonio, TX.

Mast cells are present throughout the body in low numbers. We know their role in immediate hypersensitivity and the subsequent tissue damage due to release of cytokines, vasoactive amines, and lipid mediators when mast cells are activated. Recent research has found that there is an association between an increased concentration of mast cells in the liver and the severity of hepatic fibrosis in animal models. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.029DOI Listing
April 2019
4 Reads

Steatotic and nonsteatotic scirrhous hepatocellular carcinomas reveal distinct clinicopathological features.

Hum Pathol 2019 Apr 28;86:222-232. Epub 2018 Dec 28.

Department of Pathology, Keio University School of Medicine, Tokyo 160-8582, Japan. Electronic address:

We investigated the clinicopathological and molecular characteristics of scirrhous hepatocellular carcinoma (HCC) to elucidate its uniqueness. Samples from 120 resected HCC cases underwent immunohistochemical analysis. Tumor area containing fibrous stroma and the percentage of steatotic cells within the tumor were evaluated. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.024DOI Listing
April 2019
1 Read

Clinicopathological and molecular features of SF3B1-mutated myeloproliferative neoplasms.

Hum Pathol 2019 Apr 27;86:1-11. Epub 2018 Dec 27.

Department of Pathology, Massachusetts General Hospital, 02114 Boston, MA, USA; Harvard Medical School, 02114 Boston, MA, USA. Electronic address:

The introduction of next-generation sequencing has broadened the genetic landscape of myeloproliferative neoplasms (MPNs) beyond JAK2, MPL, and CALR. However, the biological role and clinical impact of most other mutations are not well defined. We interrogated 101 genes in 143 BCR-ABL1-negative MPNs in chronic phase from 2 large institutions. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.022DOI Listing
April 2019
5 Reads

The presence of Y674/Y675 phosphorylated NTRK1 via TP53 repression of PTPN6 expression as a potential prognostic marker in neuroblastoma.

Hum Pathol 2019 Apr 27;86:182-192. Epub 2018 Dec 27.

Developmental Biology and Cancer Program, UCL, Great Ormond Street Institute of Child Health, London WC1N 1EH, UK. Electronic address:

The tumor suppressor TP53 promotes nerve growth factor receptor (NTRK1) -Y674/Y675 phosphorylation (NTRK1-pY674/pY675) via repression of the NTRK1 phosphatase PTPN6 in a ligand-independent manner, resulting in suppression of breast cancer cell proliferation. Moreover, NTRK1-pY674/pY675 together with low levels of PTPN6 and TP53 expression is associated with favorable disease-free survival of breast cancer patients. We determined whether in neuroblastoma this protein expression pattern impacts relapse-free survival (RFS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183049
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http://dx.doi.org/10.1016/j.humpath.2018.12.003DOI Listing
April 2019
3 Reads

Beyond sequence variation: assessment of copy number variation in adult glioblastoma through targeted tumor somatic profiling.

Hum Pathol 2019 Apr 27;86:170-181. Epub 2018 Dec 27.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110. Electronic address:

Glioblastoma is the most common primary malignancy of the adult central nervous system. Gliomagenesis involves a complex range of alterations, including sequence changes, copy number variations (CNVs), and epigenetic modifications, that have clinical implications for disease classification and prognosis. Thus, multiple testing modalities are required to support a complete diagnostic workup. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.12.004DOI Listing
April 2019
4 Reads

PD-L1 expression and association with malignant behavior in pheochromocytomas/paragangliomas.

Hum Pathol 2019 Apr 27;86:155-162. Epub 2018 Dec 27.

Clinical Biobank, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address:

The immunosuppressive effect of the programmed death (PD)-1/PD-L1 pathway plays an important role in the treatment of a variety of tumors, such as lung and breast cancer, but there is little literature about PD-1/PD-L1 in pheochromocytomas/paragangliomas (PCCs/PGLs). We explored the relationship of PD-L1 and malignant behavior in 77 cases of PCC/PGL using immunohistochemistry (IHC) to assess protein expression and RNAscope to detect mRNA expression in 20 cases. The IHC data showed that 59. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.10.041DOI Listing
April 2019
5 Reads

Cytomegalovirus infective gastritis in an immunocompetent host misdiagnosed as malignancy on upper gastrointestinal endoscopy: a case report and review of literature.

Hum Pathol 2018 Dec 22. Epub 2018 Dec 22.

Department of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine, Xinjiang 832002, China; Department of Pathology, Beijing Chao Yang Hospital, Capital Medical University, Beijing 100020, China. Electronic address:

Primary cytomegalovirus (CMV) infection is rare in immunocompetent hosts and generally asymptomatic. CMV infective gastritis in patients without immunosuppression is very unusual. A 44-year-old man presented with complaints of intermittent epigastric pain. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.12.005DOI Listing
December 2018
2 Reads
2.769 Impact Factor

Molecular testing of borderline cutaneous melanocytic lesions: SNP array is more sensitive and specific than FISH.

Hum Pathol 2019 Apr 18;86:115-123. Epub 2018 Dec 18.

Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA 48109-5602; Department of Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA 48109-5602. Electronic address:

Melanocytic lesions with borderline features are diagnostically challenging. Single-nucleotide polymorphism (SNP) arrays, which detect genomic copy number alterations (CNAs), can be helpful in distinguishing between nevi and melanoma. Fluorescence in situ hybridization (FISH) has been used as a more rapid, less expensive alternative to SNP array, using a panel of probes that are often gained or lost in melanoma. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.12.002DOI Listing
April 2019
4 Reads

Incidence of extramural venous invasion in colorectal carcinoma as determined at the invasive tumor front and its prognostic impact.

Hum Pathol 2019 Apr 18;86:102-107. Epub 2018 Dec 18.

Institute of Pathology, LKH Feldkirch, Carinagasse 47, 6807 Feldkirch, Austria.

Extramural venous invasion (EMVI) is prognostic for colorectal cancer; however, veins are only detected partially by normal perpendicular preparation. Therefore, reported findings are conflicting and standardization is required. A total of 239 resection specimens were examined by tangential preparation of the extramural veins at the invasive tumor front. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183048
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http://dx.doi.org/10.1016/j.humpath.2018.11.031DOI Listing
April 2019
10 Reads

Correlation of melanoma gene expression score with clinical outcomes on a series of melanocytic lesions.

Hum Pathol 2019 Apr 17;86:213-221. Epub 2018 Dec 17.

Department of Pathology, Cleveland Clinic, Cleveland, OH 44106.

A 23-gene expression signature was recently developed as an adjunct to histopathology to differentiate melanocytic nevi from melanoma. The current study correlated the gene expression signature scores to actual clinical outcomes in cases from the first validation study. RNA was extracted from 127 archival formalin-fixed paraffin-embedded tissue sections of melanocytic lesions. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.12.001DOI Listing
April 2019
3 Reads

Clinicopathological and molecular analysis of multinodular and vacuolating neuronal tumors of the cerebrum.

Hum Pathol 2019 Apr 11;86:203-212. Epub 2018 Dec 11.

Department of Pathology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Institute of Neuroscience, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. Electronic address:

Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a recently recognized rare neuronal tumor, and its pathogenesis is unclear. We analyzed 7 cases of histologically typical MVNT: 6 were adults (mean age, 43.0 years [range, 23-56 years]) and 1 was a child (age, 10 years). Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.028DOI Listing
April 2019
1 Read

Immune checkpoint blockade as a potential therapeutic strategy for undifferentiated malignancies.

Hum Pathol 2018 Dec 7;82:39-45. Epub 2018 Jul 7.

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

Undifferentiated malignancies (UMs) encompass a diverse set of aggressive tumors that pose not only a diagnostic challenge but also a challenge for clinical management. Most tumors in this category are currently treated empirically with nonspecific chemotherapeutic agents that yield extremely poor clinical response. Given that UMs are inherently genetically unstable neoplasms with the potential for immune dysregulation and increased neoantigen production, they are likely to be particularly amenable to immune checkpoint inhibitors, which target programmed cell death protein 1 (PD-1) or its ligands, PD-L1 and PD-L2, to promote T-cell antitumor activity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183025
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http://dx.doi.org/10.1016/j.humpath.2018.06.034DOI Listing
December 2018
15 Reads

Eps8, a therapeutic potential target for cancer.

Hum Pathol 2018 Dec 3;82:300-301. Epub 2018 Jul 3.

The First Affiliated Hospital of Anhui University of Chinese Medicine, 230031, Hefei, Anhui Province, China.

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183025
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http://dx.doi.org/10.1016/j.humpath.2018.04.037DOI Listing
December 2018
9 Reads

Conflicting IDH1/IDH2, ATRX, and 1p/19q results in diffuse gliomas: a commentary.

Authors:
Valeria Barresi

Hum Pathol 2018 Dec 3;82:297-298. Epub 2018 Jul 3.

Department of Human Pathology in Adulthood and Evolutive Age "Gaetano Barresi," University of Messina, 98125, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2018.04.034DOI Listing
December 2018
1 Read

Clinical utility and concordance of upper urinary tract cytology and biopsy in predicting clinicopathological features of upper urinary tract urothelial carcinoma.

Hum Pathol 2019 Apr 8;86:76-84. Epub 2018 Dec 8.

Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

Five percent of urothelial carcinoma occurs in the upper urinary tract (UUT), a challenging location to biopsy. We aim to evaluate concordance between biopsy, cytology, and resection specimens in a large upper tract urothelial carcinoma (UTUC) cohort. One hundred seventeen UTUC resections with UUT biopsy and/or cytology specimens from 2000 to 2016 were retrieved; pathologic material was re-reviewed, evaluated for concordance, and correlated with clinical information. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.021DOI Listing
April 2019
6 Reads

Three-gene immunohistochemical panel predicts progression and unfavorable prognosis in esophageal squamous cell carcinoma.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi 832002, China. Electronic address:

Esophageal squamous cell carcinoma (ESCC) is a highly invasive disease with a poor long-term survival rate. Although there has been progress in understanding the pathogenesis of ESCC, there are currently no molecular biomarkers that are used in routine clinical practices to determine prognosis. Therefore, the aim of this study was to determine a small immunohistochemical (IHC) panel that could predict the prognosis of patients with ESCC. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.027DOI Listing
December 2018
4 Reads
2.769 Impact Factor

Molecular characterization of metaplastic breast carcinoma via next-generation sequencing.

Hum Pathol 2019 Apr 8;86:85-92. Epub 2018 Dec 8.

Division of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte 91010, USA.

Metaplastic breast carcinoma (MBC) is a rare subtype of breast cancer with variable morphology. MBC is more often triple negative (ER-, PR-, HER2-) and is associated with poorer clinical outcome when compared with infiltrating ductal carcinoma. The purpose of our study is to identify molecular alterations in MBC using next-generation sequencing (NGS), which may aid chemotherapy selection and use of targeted therapy. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.023DOI Listing
April 2019
5 Reads

Clinicopathological and prognostic significance of MKK4 and MKK7 in resectable pancreatic ductal adenocarcinoma.

Hum Pathol 2019 Apr 9;86:143-154. Epub 2018 Dec 9.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100730, China. Electronic address:

Mitogen-activated protein kinase kinase 4 (MKK4) and mitogen-activated protein kinase kinase 7 (MKK7) were shown to regulate biological behavior in many malignancies. In pancreatic ductal adenocarcinoma (PDAC), it remains controversial whether MKK4 and MKK7 have pro-oncogenic or tumor-suppressive activities. Furthermore, their clinicopathological and prognostic implications are unknown. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.026DOI Listing
April 2019
1 Read

Thymic epithelial neoplasms with sebaceous differentiation: a clinicopathological and immunohistochemical study of 8 cases.

Hum Pathol 2019 Apr 8;86:124-128. Epub 2018 Dec 8.

Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston 77030, TX, USA. Electronic address:

Eight cases of primary thymic epithelial neoplasms corresponding to 7 thymomas and 1 thymic carcinoma with sebaceous differentiation are presented. The patients are 5 men and 3 women between the ages of 45 and 63 years (average, 54 years) who presented with nonspecific symptoms related to their mediastinal mass. All patients underwent complete surgical resection of the mediastinal mass. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.030DOI Listing
April 2019
9 Reads

"The other side of the coin": understanding noninvasive follicular tumor with papillary-like nuclear features in unifocal and multifocal settings.

Hum Pathol 2019 Apr 8;86:136-142. Epub 2018 Dec 8.

IPATIMUP, Institute of Molecular Pathology and Immunology of University of Porto, Porto, 4200-135, Portugal; I3S, Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, 4200-135, Portugal; Department of Pathology, Medical Faculty of Porto University, Porto, 4200-319, Portugal. Electronic address:

The recent description of noninvasive follicular tumor with papillary-like nuclear features (NIFTP) creates several diagnostic and therapeutic challenges for both the pathologist and the attending clinician. Given the concern about overtreatment of these neoplasms, the best way to manage the patients by a surgical procedure and postsurgical follow-up is still under discussion. We aimed to identify predictors of synchronous disease (eg, bilateral cancers) that can influence the appropriate type of surgery and long-term surveillance. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.10.040DOI Listing
April 2019
16 Reads

Variable somatostatin receptor subtype expression in 151 primary pheochromocytomas and paragangliomas.

Hum Pathol 2019 Apr 8;86:66-75. Epub 2018 Dec 8.

Department of Pathology, University of Helsinki and HUSLAB, Helsinki University Hospital, Helsinki FIN-00014, Finland.

Pheochromocytomas (PHEOs) and paragangliomas (PGLs) are neuroendocrine tumors that express somatostatin receptors (SSTRs), a phenomenon that constitutes a basis for tumor imaging and treatment with somatostatin analogues and peptide receptor radionuclide therapy. We studied the immunohistochemical expression of SSTR1-5 in 151 primary tumors, including 14 metastasized and 16 SDHB-deficient tumors. SSTR2 and SSTR3 were most abundantly present in these tumors, whereas the tumors were mostly negative for SSTR1, SSTR4, and SSTR5. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.020DOI Listing
April 2019
4 Reads

Low levels of glycoprotein 96 indicate a worse prognosis in early-stage hepatocellular carcinoma patients after hepatectomy.

Hum Pathol 2019 Apr 8;86:193-202. Epub 2018 Dec 8.

Department of Liver Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China. Electronic address:

Heat shock proteins are a highly conserved group of cellular proteins and are up-expressed in hepatocellular carcinoma (HCC). As a member of the heat shock protein-90 family, glycoprotein 96 (gp96) modulates immunity and tumorigenicity, is increased during the development of HCC from normal liver tissue, and is considered a pro-oncogenic chaperone. However, the prognostic value of gp96 has not been well clarified. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.025DOI Listing
April 2019
2 Reads
2.769 Impact Factor