10,501 results match your criteria Human Pathology [Journal]


TPL2, a therapeutic potential target for cancer.

Hum Pathol 2019 Jan 6;83:224. Epub 2018 Jul 6.

The First Affiliated Hospital of Anhui University of Chinese Medicine, 230031, Hefei, Anhui Province, China.

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http://dx.doi.org/10.1016/j.humpath.2018.05.028DOI Listing
January 2019

Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, serrated and MSI colorectal neoplasia.

Hum Pathol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pharmacology & Experimental Therapeutics, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA, United States. Electronic address:

Colorectal cancers (CRCs) initiate through distinct mutations, including in APC pathway components leading to tubular adenomas (TAs); in BRAF, with epigenetic silencing of CDX2, leading to serrated adenomas (SAs); and in the DNA mismatch repair machinery driving microsatellite instability (MSI). Transformation through the APC pathway involves loss of the hormone GUCA2A that silences the tumor suppressing receptor GUCY2C. Indeed, oral hormone replacement is an emerging strategy to reactivate GUCY2C and prevent CRC initiation and progression. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.032DOI Listing
February 2019
1 Read

Incidental non-neoplastic parenchymal findings in patients undergoing lung resection for mass lesions.

Hum Pathol 2019 Jan 15. Epub 2019 Jan 15.

Department of Pathology, 75 Francis Street, Brigham and Women's Hospital, Boston, MA, 02115. Electronic address:

The prevalence of incidental non-neoplastic lung disease in patients undergoing resection for mass lesions is unknown. We determined the prevalence and characteristics of parenchymal findings in patients with lung nodules, aiming to increase awareness of findings that could potentially impact patient management. 397 patients with benign or malignant mass lesions with available pre-surgical chest computed tomography scans resected between January 2001 and July 2015 were included. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.01.002DOI Listing
January 2019
5 Reads

Myositis ossificans mimicking metaplastic breast cancer on core needle biopsy.

Hum Pathol 2019 Jan 11. Epub 2019 Jan 11.

Institute of Pathology, University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.

Myositis ossificans (MO) is an uncommon myofibroblastic proliferation that may closely mimic sarcoma. A 33-year old woman presented with a 2cm breast mass. A core needle biopsy showed highly cellular spindle cell proliferations with atypia and high proliferation activity. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.12.008DOI Listing
January 2019
1 Read

GATA6: a new predictor for prognosis in ovarian Cancer.

Hum Pathol 2019 Jan 8. Epub 2019 Jan 8.

Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA,TX 77030. Electronic address:

Ovarian cancer (OC) is the main cause of gynecological cancer-associated mortality. Improving the diagnosis is important for guiding clinical treatment. The present study aimed to investigate the relationship between expression of GATA6, a stem cell factor, and its prognosis in OC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177193000
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http://dx.doi.org/10.1016/j.humpath.2019.01.001DOI Listing
January 2019
3 Reads

PD-L1 and CD8 are associated with deficient mismatch repair status in triple-negative and HER2-positive breast cancers.

Hum Pathol 2019 Jan 8. Epub 2019 Jan 8.

Department of Pathology, Wexner Medical Center at The Ohio State University, 410 W. 10th Ave, Columbus, OH 43210. Electronic address:

Triple-negative and HER2-positive breast cancers (BCs) are more aggressive than hormone receptor-positive/HER2-negative BCs and show higher levels of tumor infiltrating lymphocytes (TILs) and PD-L1 expression. Recently, US Food and Drug Administration approved anti-PD-L1 immunotherapy for solid tumors with deficient mismatch repair (MMR). In this study, we aimed to examine the prevalence of deficient MMR and its association with checkpoint immune markers in BCs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177193000
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http://dx.doi.org/10.1016/j.humpath.2018.12.007DOI Listing
January 2019
5 Reads

New fusion sarcomas histopathology and clinical significance of selected entities.

Hum Pathol 2019 Jan 8. Epub 2019 Jan 8.

Laboratory of Pathology, National Cancer Institute, Bethesda, MD.

Many sarcomas contain gene fusions that can be pathogenetic mechanisms and diagnostic markers. In this article we review selected fusion sarcomas and techniques for their detection. CIC-DUX4 fusion sarcoma is a round-cell tumor now considered an entity separate from Ewing sarcoma with a more aggressive clinical course, occurrence in older age, and predilection to soft tissues. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.12.006DOI Listing
January 2019
9 Reads

Hepatic mast cell concentration directly correlates to stage of fibrosis in NASH.

Hum Pathol 2018 Dec 28. Epub 2018 Dec 28.

Pinnacle Clinical Research, San Antonio, TX.

Mast cells are present throughout the body in low numbers. We know their role in immediate hypersensitivity and the subsequent tissue damage due to release of cytokines, vasoactive amines, and lipid mediators when mast cells are activated. Recent research has found that there is an association between an increased concentration of mast cells in the liver and the severity of hepatic fibrosis in animal models. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.029DOI Listing
December 2018
2 Reads

Steatotic and Nonsteatotic Scirrhous hepatocellular carcinomas reveal distinct Clinicopathological features.

Hum Pathol 2018 Dec 28. Epub 2018 Dec 28.

Department of Pathology, Keio University School of Medicine, Tokyo 160-8582, Japan. Electronic address:

We investigated the clinicopathological and molecular characteristics of scirrhous hepatocellular carcinoma (HCC) to elucidate its uniqueness. Samples from 120 resected HCC cases underwent immunohistochemical analysis. Tumor area containing fibrous stroma and the percentage of steatotic cells within the tumor were evaluated. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.024DOI Listing
December 2018

Clinicopathological and molecular features of SF3B1-mutated myeloproliferative neoplasms.

Hum Pathol 2018 Dec 27. Epub 2018 Dec 27.

Department of Pathology, Massachusetts General Hospital, 02114, Boston, MA, USA; Harvard Medical School, 02114, Boston, MA, USA. Electronic address:

The introduction of next-generation sequencing has broadened the genetic landscape of myeloproliferative neoplasms (MPNs) beyond JAK2, MPL and CALR. However, the biological role and clinical impact of most other mutations is not well defined. We interrogated 101 genes in 143 BCR-ABL1-negative MPNs in chronic phase from two large institutions. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.022DOI Listing
December 2018
1 Read

The presence of Y674/Y675 phosphorylated NTRK1 via TP53 repression of PTPN6 expression as a potential prognostic marker in neuroblastoma.

Hum Pathol 2018 Dec 27. Epub 2018 Dec 27.

Developmental Biology and Cancer Program, UCL, Great Ormond Street Institute of Child Health, 30 Guildford Street, London WC1N 1EH, UK. Electronic address:

The tumor suppressor TP53, promotes nerve growth factor receptor (NTRK1) Y674/Y675-phosphorylation (NTRK1-pY674/pY675), via repression of the NTRK1-phosphatase PTPN6, in a ligand independent manner, resulting in suppression of breast-cancer cell proliferation. Moreover, NTRK1-pY674/pY675 together with low levels of PTPN6 and TP53 expression is associated with favorable disease-free survival of breast-cancer patients. We determined whether in neuroblastoma this protein expression pattern impacts on relapse-free-survival (RFS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183049
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http://dx.doi.org/10.1016/j.humpath.2018.12.003DOI Listing
December 2018
1 Read

Beyond sequence variation: assessment of copy number variation in adult glioblastoma through targeted tumor somatic profiling.

Hum Pathol 2018 Dec 27. Epub 2018 Dec 27.

Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO. Electronic address:

Glioblastoma is the most common primary malignancy of the adult central nervous system. Gliomagenesis involves a complex range of alterations, including sequence changes, copy number variations (CNVs), and epigenetic modifications, that have clinical implications for disease classification and prognosis. Thus, multiple testing modalities are required to support a complete diagnostic workup. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.12.004DOI Listing
December 2018
1 Read

PD-L1 expression and association with malignant behavior in pheochromocytomas/paragangliomas.

Hum Pathol 2018 Dec 27. Epub 2018 Dec 27.

Central Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address:

The immunosuppressive effect of the programmed death (PD)-1/PD-L1 pathway plays an important role in the treatment of a variety of tumors, such as lung and breast cancer, but there is little literature about PD-1/PD-L1 in pheochromocytomas/paragangliomas (PCC/PGLs). We explored the relationship of PD-L1 and malignant behavior in 77 cases of PCC/PGL using immunohistochemistry (IHC) to assess protein expression and RNAscope to detect mRNA expression in 20 cases. The IHC data showed that 59. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.10.041DOI Listing
December 2018
2 Reads

Cytomegalovirus infective gastritis in an immunocompetent host misdiagnosed as malignancy on upper gastrointestinal endoscopy: a case report and review of literature.

Hum Pathol 2018 Dec 22. Epub 2018 Dec 22.

Department of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine, Xinjiang 832002, China; Department of Pathology, Beijing Chao Yang Hospital, Capital Medical University,Beijing 100020, China. Electronic address:

Primary cytomegalovirus (CMV) infection is rare in immunocompetent hosts and generally asymptomatic. CMV infective gastritis in patients without immunosuppression is very unusual. A 44-year-old man presented with complaints of intermittent epigastric pain. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.12.005DOI Listing
December 2018
2.769 Impact Factor

Molecular testing of borderline cutaneous melanocytic lesions: SNP Array is more sensitive and specific than FISH.

Hum Pathol 2018 Dec 18. Epub 2018 Dec 18.

Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA; Department of Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Melanocytic lesions with borderline features are diagnostically challenging. Single nucleotide polymorphism (SNP) arrays, which detect genomic copy number alterations (CNAs), can be helpful in distinguishing between nevi and melanoma. Fluorescence in situ hybridization (FISH) has been used as a more rapid, less expensive alternative to SNP array, employing a panel of probes that are often gained or lost in melanoma. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.12.002DOI Listing
December 2018
2 Reads

Incidence of extramural venous invasion in colorectal carcinoma as determined at the invasive tumor front and its prognostic impact.

Hum Pathol 2018 Dec 17. Epub 2018 Dec 17.

Institute of Pathology, LKH Feldkirch, Carinagasse 47, 6807 Feldkirch, Austria.

Extramural venous invasion (EMVI) is prognostic for colorectal cancer, however veins are only detected partially by normal perpendicular preparation. Therefore reported findings are conflicting and standardization is required. 239 resection specimens were examined by tangential preparation of the extramural veins at the invasive tumor front. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183048
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http://dx.doi.org/10.1016/j.humpath.2018.11.031DOI Listing
December 2018
4 Reads

Correlation of melanoma gene expression score with clinical outcomes on a series of melanocytic lesions.

Hum Pathol 2018 Dec 16. Epub 2018 Dec 16.

Department of Pathology, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH 44106.

A 23-gene expression signature was recently developed as an adjunct to histopathology to differentiate melanocytic nevi from melanoma. The current study correlated the gene expression signature scores to actual clinical outcomes in cases from the first validation study. RNA was extracted from 127 archival formalin-fixed paraffin-embedded tissue sections of melanocytic lesions. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.12.001DOI Listing
December 2018
1 Read

Clinicopathological and molecular analysis of multinodular and vacuolating neuronal tumors of the cerebrum.

Hum Pathol 2018 Dec 11. Epub 2018 Dec 11.

Department of Pathology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Neuroscience, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a recently recognized rare neuronal tumor, and its pathogenesis is unclear. We analyzed 7 cases of histologically typical MVNT: six were adults [mean age: 43.0years (range: 23-56)] and one was a child (10-year-old). Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.028DOI Listing
December 2018

Immune checkpoint blockade as a potential therapeutic strategy for undifferentiated malignancies.

Hum Pathol 2018 Dec 7;82:39-45. Epub 2018 Jul 7.

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

Undifferentiated malignancies (UMs) encompass a diverse set of aggressive tumors that pose not only a diagnostic challenge but also a challenge for clinical management. Most tumors in this category are currently treated empirically with nonspecific chemotherapeutic agents that yield extremely poor clinical response. Given that UMs are inherently genetically unstable neoplasms with the potential for immune dysregulation and increased neoantigen production, they are likely to be particularly amenable to immune checkpoint inhibitors, which target programmed cell death protein 1 (PD-1) or its ligands, PD-L1 and PD-L2, to promote T-cell antitumor activity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183025
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http://dx.doi.org/10.1016/j.humpath.2018.06.034DOI Listing
December 2018
9 Reads

Eps8, a therapeutic potential target for cancer.

Hum Pathol 2018 Dec 3;82:300-301. Epub 2018 Jul 3.

The First Affiliated Hospital of Anhui University of Chinese Medicine, 230031, Hefei, Anhui Province, China.

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183025
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http://dx.doi.org/10.1016/j.humpath.2018.04.037DOI Listing
December 2018
6 Reads

Conflicting IDH1/IDH2, ATRX, and 1p/19q results in diffuse gliomas: a commentary.

Authors:
Valeria Barresi

Hum Pathol 2018 Dec 3;82:297-298. Epub 2018 Jul 3.

Department of Human Pathology in Adulthood and Evolutive Age "Gaetano Barresi," University of Messina, 98125, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2018.04.034DOI Listing
December 2018

Clinical utility and concordance of upper urinary tract cytology and biopsy in predicting Clinicopathologic features of upper urinary tract urothelial carcinoma.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology, University of Michigan, 2800 Plymouth Road, Building 35, Ann Arbor, MI 48109, USA; Michigan Center for Translational Pathology, 5309 CCC 5940, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, 1500 E Medical Center Drive, Ann Arbor, MI, 48109, USA. Electronic address:

5% of urothelial carcinoma occurs in the upper urinary tract (UUT), a challenging location to biopsy. We aim to evaluate concordance between biopsy, cytology, and resection specimens in a large upper tract urothelial carcinoma (UTUC) cohort.117 UTUC resections with UUT biopsy and/or cytology specimens from 2000-2016 were retrieved; pathologic material was re-reviewed, evaluated for concordance, and correlated with clinical information. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.021DOI Listing
December 2018
4 Reads

Three-gene immunohistochemical panel predicts progression and unfavorable prognosis in esophageal squamous cell carcinoma.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi 832002, China. Electronic address:

Esophageal squamous cell carcinoma (ESCC) is a highly invasive disease with a poor long-term survival rate. Although there has been progress in understanding the pathogenesis of ESCC, there are currently no molecular biomarkers that are used in routine clinical practices to determine prognosis. Therefore, the aim of this study was to determine a small immunohistochemical (IHC) panel that could predict the prognosis of patients with ESCC. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.027DOI Listing
December 2018
2 Reads
2.769 Impact Factor

Molecular characterization of metaplastic breast carcinoma via next generation sequencing.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Division of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte 91010, USA.

Metaplastic breast carcinoma (MBC) is a rare subtype of breast cancer with variable morphology. MBC is more often triple negative (ER-, PR-, HER2-) and is associated with poorer clinical outcome when compared to infiltrating ductal carcinoma. The purpose of our study is to identify molecular alterations in MBC using next generation sequencing (NGS) which may aid chemotherapy selection and use of targeted therapy. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.023DOI Listing
December 2018
3 Reads

Clinicopathologic and prognostic significance of MKK4 and MKK7 in resectable pancreatic ductal adenocarcinoma.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100730, China. Electronic address:

Mitogen-activated protein kinase kinase 4 (MKK4) and mitogen-activated protein kinase kinase 7 (MKK7) were shown to regulate biological behavior in many malignancies. In pancreatic ductal adenocarcinoma (PDAC), it remains controversial whether MKK4 and MKK7 have pro-oncogenic or tumor-suppressive activities. Furthermore, their clinicopathologic and prognostic implications are unknown. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.026DOI Listing
December 2018

Thymic epithelial neoplasms with sebaceous differentiation: a clinicopathological and Immunohistochemical study of 8 cases.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology, The university of Texas, M D Anderson Cancer Center, Houston, TX. Electronic address:

Eight cases of primary thymic epithelial neoplasms corresponding to seven thymomas and one thymic carcinoma with sebaceous differentiation are presented. The patients are five men and three women between the ages of 45 and 63years (average: 54years) who presented with non-specific symptomatology related to their mediastinal mass. All patients underwent complete surgical resection of the mediastinal mass. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.030DOI Listing
December 2018
7 Reads

"The other side of the coin": understanding noninvasive follicular tumor with papillary-like nuclear features in Unifocal and multifocal settings.

Hum Pathol 2018 Dec 7. Epub 2018 Dec 7.

IPATIMUP, Institute of Molecular Pathology and Immunology of University of Porto, Porto, Portugal; I3S, Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal; Department of Pathology, Medical Faculty of Porto University, Porto, Portugal. Electronic address:

The recent description of noninvasive follicular tumor with papillary-like nuclear features (NIFTP) creates several diagnostic and therapeutic challenges for both the pathologist and the attending clinician. Given the concern about overtreatment of these neoplasms, the best way to manage the patients by a surgical procedure and post-surgical follow-up is still under discussion. We aimed to identify predictors of synchronous disease (eg, bilateral cancers) that can influence the appropriate type of surgery and long-term surveillance. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.10.040DOI Listing
December 2018
5 Reads

Variable somatostatin receptor subtype expression in 151 primary pheochromocytomas and paragangliomas.

Hum Pathol 2018 Dec 7. Epub 2018 Dec 7.

Department of Pathology, University of Helsinki and HUSLAB, Helsinki University Hospital, Haartmaninkatu 3, (P.O. Box 21, ), FIN-00014 University of Helsinki, Helsinki, Finland.

Pheochromocytomas (PHEOs) and paragangliomas (PGLs) are neuroendocrine tumors (NETs) that express somatostatin receptors (SSTRs), a phenomenon that constitutes a basis for tumor imaging and treatment with somatostatin analogues and Peptide Receptor Radionuclide Therapy (PRRT). We studied the immunohistochemical expression of SSTR1-5 in 151 primary tumors, including 14 metastasized and 16 SDHB-deficient tumors. SSTR2 and SSTR3 were most abundantly present in these tumors, whereas the tumors were mostly negative for SSTR1, SSTR4 and SSTR5. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.020DOI Listing
December 2018

Low levels of gp96 indicate a worse prognosis in early-stage HCC patients after hepatectomy.

Hum Pathol 2018 Dec 7. Epub 2018 Dec 7.

Department of Liver Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China. Electronic address:

Heat shock proteins (HSP) are a highly conserved group of cellular proteins, and are up-expressed in hepatocellular carcinoma (HCC). As a member of the HSP90 family, gp96 modulates immunity and tumorigenicity, is increased during the development of HCC from normal liver tissue, and is considered a pro-oncogenic chaperone. However, the prognostic value of gp96 has not been well clarified. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.025DOI Listing
December 2018
1 Read
2.769 Impact Factor

Insulinoma-associated protein 1 immunostaining on cytology specimens: an institutional experience.

Hum Pathol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pathology, Division of Cytopathology, The Johns Hopkins Hospital, Baltimore, USA.

Neuroendocrine tumors (NET) are epithelial neoplasms with prominent neuroendocrine differentiation. Cytologic examination and utilization of immunohistochemical (IHC) markers are important diagnostic tools for the evaluation of these tumors. Herein we report our experience with the application of INSM1 in cytology samples. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.10.035DOI Listing
November 2018
2 Reads

Histone deacetylase-1 as a prognostic factor and mediator of gastric cancer progression by enhancing glycolysis.

Hum Pathol 2018 Nov 27. Epub 2018 Nov 27.

Department of Gastroenterology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006,China. Electronic address:

Histone deacetylase 1 (HDAC1) has been shown to be closely associated with tumor development. We investigated its effects on survival and biological behavior in gastric cancer (GC). HDAC1 expression and glycolysis activity were analyzed in a cohort of 252 samples of primary GC tumors and in vitro study. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.10.031DOI Listing
November 2018

Management of Patients with renal mass lesions based on renal biopsy cytology results.

Hum Pathol 2018 Nov 27. Epub 2018 Nov 27.

Northwestern University, Chicago, IL. Electronic address:

The benefit of renal biopsy, especially in patients with a history of malignancy (HOM), has not been well-studied. We studied the clinical management of 339 renal masses following fine needle aspirate (FNA) and/or core needle biopsy (CNB) with touch preparation. 41% of patients had HOM, which did not increase the incidence of renal malignancy. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.010DOI Listing
November 2018
8 Reads

Overexpression of serum response factor is correlated with poor prognosis in patients with gastric cancer.

Hum Pathol 2018 Nov 27. Epub 2018 Nov 27.

State key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Military Medical University/ Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, PR China. Electronic address:

Serum response factor (SRF) is highly expressed in many tumors, including gastric cancer. However, the exact prognostic utility of SRF in patients with gastric cancer remains unclear. Therefore, in this study, we investigated the expression and prognostic value of SRF in patients with gastric cancer. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.10.018DOI Listing
November 2018
2.769 Impact Factor

p53 expression in large B-cell lymphomas with MYC extra copies and CD99 expression in large B-cell lymphomas in relation to MYC status.

Hum Pathol 2018 Nov 26. Epub 2018 Nov 26.

Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA. Electronic address:

p53 expression and MYC-extra copies (MYC-EC) have been reported to serve as independent adverse prognostic markers in patients with diffuse large B-cell lymphoma (DLBCL). However, the impact of p53 expression in MYC-EC lymphomas has not been delineated. Conversely, CD99 expression has been shown to have a positive impact on survival in patients with germinal center-type DLBCL, yet nothing is reported about the impact of CD99 expression and MYC status. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.015DOI Listing
November 2018

"Contribution of the clinical information to the accuracy of the minimally invasive and the complete diagnostic autopsy".

Hum Pathol 2018 Nov 26. Epub 2018 Nov 26.

Department of Pathology, Maputo, Central Hospital, 1100 Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, 1100 Maputo, Mozambique.

Although autopsy diagnosis includes routinely, a thorough evaluation of all available pathological results and also of any available clinical data, the contribution of this clinical information to the diagnostic yield of the autopsy has not been analyzed. We aimed to determine to which degree the use of clinical data improves the diagnostic accuracy of the complete diagnostic autopsy (CDA) and the minimally invasive autopsy (MIA), a simplified pathological postmortem procedure designed for low-income sites. 264 coupled MIA and CDA procedures (112 adults, 57 maternal deaths, 54 children and 41 neonates) were performed at the Maputo hospital, Mozambique. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.10.037DOI Listing
November 2018
2 Reads
2.769 Impact Factor

High-grade squamous cell carcinoma arising in a Tibial Adamantinoma.

Hum Pathol 2018 Nov 26. Epub 2018 Nov 26.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester MN. Electronic address:

Adamantinoma of the long bones is a rare, typically low-grade malignant tumor that frequently involves the tibia. Radiographically, adamantinoma is characteristically a lytic, intracortical and expansile lesion with variable margins. Histologically, adamantinoma is a bimorphic neoplasm, composed of epithelial and osteofibrous elements. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.018DOI Listing
November 2018
2 Reads

PIK3CA hotspot mutations and cyclooxygenase-2 expression in ovarian clear cell carcinomas: a close association with stromal features.

Hum Pathol 2018 Nov 26. Epub 2018 Nov 26.

Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki.

Ovarian clear cell carcinomas (CCCs) have 2 distinct stromas: a hyalinized/mucoid stroma and a plasma cell-rich inflammatory stroma. Clinically, CCC is the most common ovarian cancer associated with thromboembolism. Recent studies suggested a potential role of PIK3CA mutation in the cyclooxygenase (COX) pathway, which mediates inflammation or hemostasis. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.013DOI Listing
November 2018
1 Read

High expression of ALPPL2 is associated with poor prognosis in gastric cancer.

Hum Pathol 2018 Nov 26. Epub 2018 Nov 26.

Department of Education and Training Office, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China. Electronic address:

Alkaline phosphatase placental-like 2 (ALPPL2) is a member of the ALPP alkaline phosphatase family and is reported to be associated with the growth of some tumors. Gastric cancer is one of the most common cancers worldwide. We previously identified a distinct expression pattern of ALPPL2 between gastric cancer and adjacent normal tissues. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183047
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http://dx.doi.org/10.1016/j.humpath.2018.11.019DOI Listing
November 2018

Paip1 predicts poor prognosis and promotes tumor progression through AKT/GSK-3β pathway in lung adenocarcinoma.

Hum Pathol 2018 Nov 26. Epub 2018 Nov 26.

Department of Pathology & Cancer Research Center, Yanbian University Medical College, Yanji 133002, China; Key laboratory of the Science and Technology Department of Jilin Province, Yanji 133002, China. Electronic address:

The expression and biological function of Paip1 remains poorly understood in most human cancers. The objective of this research is to investigate its clinical significance and roles in lung adenocarcinoma (LADC). Immunohistochemistry was used to determine Paip1 expression in 58 cases of LADC patients with strict follow-up and 60 cases of adjacent normal lung tissues. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.017DOI Listing
November 2018
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Molecular features of pleomorphic xanthoastrocytoma.

Hum Pathol 2018 Nov 26. Epub 2018 Nov 26.

Department of Pathology, Xiangya Hospital, Central South University, Changsha, China; Department of Pathology, Xiangya Medical School, Central South University, Changsha; Department of Pathology, Institute of Basic Medicine, Xinjiang Medical University, Urumqi, China. Electronic address:

Pleomorphic xanthoastrocytoma (PXA) is a rare central nervous system tumor occurring mostly in children and young adults. Next-generation sequencing of 295 cancer-related genes was used to investigate the molecular profiles of 13 cases of PXA. We found that BRAF V600E (5/13; 38%), FANCA/D2/I/M (5/13; 38%), PRKDC (4/13; 31%), NF1 (3/13; 23%), and NOTCH2/3/4 (3/13; 23%) alterations were the most frequent somatic gene mutations. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.08.038DOI Listing
November 2018
8 Reads

Evolving concepts in prostatic neuroendocrine manifestations: from focal divergent differentiation to AMPHICRINE carcinoma.

Hum Pathol 2018 Nov 24. Epub 2018 Nov 24.

Department of Pathology, University Health Network, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Endocrine Oncology, The Princess Margaret Cancer Centre, Toronto, ON, Canada. Electronic address:

Prostatic neuroendocrine manifestations encompass a heterogeneous spectrum of morphological entities. In the era of evidence-based and precision-led treatment, distinction of biologically relevant clinical manifestations expanded the evolving clinical role of pathologists. Recent observations on the occurrence of hormone-therapy induced aggressive prostatic cancers with neuroendocrine features have triggered the need to refine the spectrum and nomenclature of prostatic neuroendocrine manifestations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183046
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http://dx.doi.org/10.1016/j.humpath.2018.11.016DOI Listing
November 2018
11 Reads

Clinical validation of coexisting driver mutations in colorectal cancers.

Hum Pathol 2018 Nov 24. Epub 2018 Nov 24.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Mutational profiling is recommended for selecting targeted therapy and predicting prognosis of metastatic colorectal cancer (CRC). Detection of coexisting mutations within the same pathway, which are usually mutually exclusive, raises the concern for potential laboratory errors. In this retrospective study for quality assessment of a next generation sequencing assay, we examined BRAF, KRAS and NRAS genes within the mitogen-activated protein kinase (MAPK) pathway and the PIK3CA gene within the phosphatidylinositol 3-kinase (mTOR) pathway in 744 CRC specimens submitted to our clinical diagnostics laboratory. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183046
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http://dx.doi.org/10.1016/j.humpath.2018.11.014DOI Listing
November 2018
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Greetings from the new Editor-in-Chief of Human Pathology.

Authors:

Hum Pathol 2019 Jan 23;83. Epub 2018 Nov 23.

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http://dx.doi.org/10.1016/j.humpath.2018.11.012DOI Listing
January 2019

HuC/D expression in small round cell tumors and neuroendocrine tumors: a useful tool for distinguishing neuroblastoma from childhood small round cell tumors.

Hum Pathol 2018 Nov 20. Epub 2018 Nov 20.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address:

The RNA-binding protein HuC/D displays a neuron-specific expression and is involved in neuronal differentiation and the maintenance of the nervous system. Here we investigated the diagnostic value of HuC/D in neuroblastomas. We evaluated 85 neuroblastic tumors: 81 neuroblastomas; three ganglioneuroblastomas, intermixed; one ganglioneuroma, maturing, and 101 other tumors consisting of 34 Ewing sarcomas, 14 nephroblastomas, 11 rhabdomyosarcomas, 15 pulmonary small cell carcinomas, 18 pancreatic neuroendocrine tumors, and nine pheochromocytomas. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.004DOI Listing
November 2018
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A combination of GATA3 and SOX10 is useful for the diagnosis of metastatic triple negative breast Cancer.

Hum Pathol 2018 Nov 20. Epub 2018 Nov 20.

The Ohio State University Wexner Medical Center Department of Pathology.

In metastatic breast cancer (MBC), it can be difficult to establish the origin if the primary tumor is triple negative or if there is a loss of biomarker expression. SOX10 expression has been reported in primary triple negative breast cancer but is poorly studied in metastatic lesions. In this study, the diagnostic utility of a panel of SOX10, GATA3, and androgen receptor (AR) in MBC negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) was evaluated and compared to the expression of these markers in the matched primary breast cancer (PBC). Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.005DOI Listing
November 2018
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Prognostic importance of mitochondrial markers in mucosal and cutaneous head and neck melanomas.

Hum Pathol 2018 Nov 20. Epub 2018 Nov 20.

Department of Oral Diagnosis, Area of Pathology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.

Mitochondrial dysfunction is caused by an imbalance in the fission and fusion processes, and it has been implicated in the pathogenesis of several human cancers. However, the role of mitochondrial markers in melanomas still remain poorly understood. In this study, the authors assessed the expression of three mitochondrial markers [antimitochondrial (AMT), fission protein 1 (FIS1) and mitofusin 2 (MFN2)] in a series of head and neck mucosal and cutaneous melanomas. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.009DOI Listing
November 2018
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Driver mutation profiles and clinicopathological correlation in pulmonary adenocarcinoma with a micropapillary component.

Hum Pathol 2018 Nov 19. Epub 2018 Nov 19.

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China. Electronic address:

Pulmonary adenocarcinoma (PA) with a micropapillary component (PA-MPC) is considered a highly aggressive neoplasm. The molecular profile of PA-MPC has not yet been clearly elucidated. Based on these, we performed next-generation sequencing and quantitative real-time polymerase chain reaction to detect the driver mutation profiles of fifty PA-MPC cases and confirmed the results by Sanger sequencing. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.008DOI Listing
November 2018
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Evaluation of miR-16 as an internal control in the patients with breast cancer.

Hum Pathol 2018 Nov 17. Epub 2018 Nov 17.

Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2018.10.034DOI Listing
November 2018
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Heterogeneous mutational profile and prognosis conferred by TP53 mutations in Appendiceal mucinous neoplasms.

Hum Pathol 2018 Nov 17. Epub 2018 Nov 17.

Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA, USA. Electronic address:

The 8th edition of American Joint Committee on Cancer (AJCC) advocates a three-tier grading system for appendiceal mucinous tumors. The mutational profile for each tumor grade and the impact of TP53 mutation on survival is unknown.We classified appendiceal mucinous tumors into 3 grades based on the 8th edition of AJCC: 21G1 low-grade mucinous neoplasms, 21G2 appendiceal adenocarcinomas, and 26G3 signet ring cell carcinomas (SRC). Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.011DOI Listing
November 2018
17 Reads