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    Prevalence of Human Papillomavirus Genotypes and Abnormal Pap Smears Among Women in the Military Health System.
    J Community Health 2017 Nov 22. Epub 2017 Nov 22.
    Adolescent Medicine, Joint Base San Antonio/Lackland AFB, San Antonio, TX, USA.
    Human papillomavirus infection (HPV) is the most common sexually transmitted infection among United States Military Servicemembers, and present in the majority of cervical cancers. Many of these infections are preventable, but HPV immunization is not mandatory during military service. The objective of this study was to examine the prevalence of vaccine-preventable cervical disease among women enrolled in the San Antonio Military Health System. Read More

    4-Valent Human Papillomavirus (4vHPV) Vaccine in Preadolescents and Adolescents After 10 Years.
    Pediatrics 2017 Nov 22. Epub 2017 Nov 22.
    Merck & Company Inc, Kenilworth, New Jersey
    Objectives: We describe the final 10-year data for the long-term follow-up study of the 4-valent human papillomavirus (4vHPV) vaccine in preadolescents and adolescents.

    Methods: In the base study (V501-018), 1661 sexually inactive boys and girls received the 4vHPV vaccine (early vaccination group [EVG], managed for 9.9 years) or a placebo at day 1, month 2, and month 6. Read More

    Clinical, laboratory and epidemiological aspects of HPV infection in a low-income population from South Bahia, Brazil.
    Epidemiol Infect 2017 Nov 23:1-7. Epub 2017 Nov 23.
    Laboratório de Farmacogenômica e Epidemiologia Molecular,Departamento de Ciências Biológicas,Universidade Estadual de Santa Cruz,Ilhéus,Bahia,Brazil.
    The aim of this study was to determine the prevalence and risk factors for human papillomavirus (HPV) infection in the Southern region of the State of Bahia, evaluating the performance of alternative complementary methods for cervical lesion detection. Cervical samples from women who attended healthcare units were collected and diagnosed by visual inspection, cervical cytology and nested polymerase chain reaction (PCR). Moreover, hemi-nested PCR was performed to detect different HPV genotypes. Read More

    Pigmented Bowen's disease associated with high-risk HPV simulating melanoma of the hand.
    An Bras Dermatol 2017 Sep-Oct;92(5):686-688
    Private clinic - Piracicaba (SP), Brazil.
    Bowen's disease is an in situ squamous cell carcinoma of the skin with only 2% of pigmented cases reported. It is clinically characterized by papules and plaques of blackened surface that may be caused either by sun damage - usually in photoexposed areas in elderly individuals - or by human papillomavirus infection - usually in the anogenital region of young adults. Dermoscopic aspects of Bowen's disease are discussed for over a decade, but with no definitive criteria that would lead to a definitive diagnosis. Read More

    Anogenital warts in pediatric population.
    An Bras Dermatol 2017 Sep-Oct;92(5):675-681
    Department of Dermatology and Venereology, Centro Hospitalar São João, EPE, Faculdade de Medicina da Universidade do Porto - Porto, Portugal.
    The approach to children with anogenital warts in the context of sexual abuse is a challenge in clinical practice. This study aims to review the current knowledge of anogenital warts in children, the forms of transmission, and the association with sexual abuse and to propose a cross-sectional approach involving all medical specialties. A systematic review of the literature was conducted in Portuguese and English from January 2000 to June 2016 using the ISI Web of Knowledge and PubMed databases. Read More

    Acquisition, Persistence, and Clearance of Human Papillomavirus Infection among Male Virgins Residing in Brazil, Mexico, and the United States.
    J Infect Dis 2017 Nov 18. Epub 2017 Nov 18.
    Center for Infection Research in Cancer, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
    Background: Little is known about the natural history of HPV infection in male virgins. This study estimated incidence and clearance of genital HPV, and factors associated with HPV, among men who deny ever engaging in penetrative sex at baseline.

    Methods: A cohort of 4123 men residing in Brazil, Mexico, and the USA were followed every 6 months for up to 10 visits. Read More

    Delineation of the HPV11E6 and HPV18E6 Pathways in Initiating Cellular Transformation.
    Front Oncol 2017 1;7:258. Epub 2017 Nov 1.
    Faculty of Health Sciences, Division of Medical Biochemistry and Structural Biology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
    Although high-risk human papillomaviruses (HPVs) are the major risk factors for cervical cancer they have been associated with several other cancers, such as head and neck and oral cancers. Since integration of low-risk HPV11 DNA has been demonstrated in esophageal tumor genomes, this study compared the effects of low-risk HPV11E6 and high-risk HPV18E6 on cellular gene expression. The HPV11E6 and HPV18E6 genes were cloned into an adenoviral vector and expressed in human keratinocytes (HaCaT) in order to investigate early events and to eliminate possible artifacts introduced by selective survival of fast growing cells in stable transfection experiments. Read More

    Hypoxia-inducible factor-1α activation in HPV-positive head and neck squamous cell carcinoma cell lines.
    Oncotarget 2017 Oct 11;8(52):89681-89691. Epub 2017 Sep 11.
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, Giessen, Germany.
    Purpose: Human papillomavirus (HPV) is a causative agent for a rising number of head and neck squamous cell carcinomas (HNSCC), which are characterized by distinct tumor biology. Hypoxia inducible-factor (HIF) signaling influences initiation and progression of carcinogenesis and HPV oncoproteins have evolved to highjack cellular pathways for viral reproduction. Therefore, we investigated whether HPV activates HIF-1α expression in HNSCC. Read More

    Persistence of an Oncogenic Papillomavirus Genome Requires cis Elements from the Viral Transcriptional Enhancer.
    MBio 2017 Nov 21;8(6). Epub 2017 Nov 21.
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Human papillomavirus (HPV) genomes are replicated and maintained as extrachromosomal plasmids during persistent infection. The viral E2 proteins are thought to promote stable maintenance replication by tethering the viral DNA to host chromatin. However, this has been very difficult to prove genetically, as the E2 protein is involved in transcriptional regulation and initiation of replication, as well as its assumed role in genome maintenance. Read More

    Text messages to increase attendance to follow-up cervical cancer screening appointments among HPV-positive Tanzanian women (Connected2Care): study protocol for a randomised controlled trial.
    Trials 2017 Nov 21;18(1):555. Epub 2017 Nov 21.
    Department of Obstetrics and Gynaecology, Odense University Hospital, Odense, Denmark.
    Background: Cervical cancer is a major health concern in Tanzania, caused by poor attendance for cervical cancer screening and follow-up of women at risk. Mobile telephone health interventions are proven effective tools to improve health behaviour in African countries. So far, no knowledge exists on how such interventions may perform in relation to cervical cancer screening in low-income settings. Read More

    Presenting symptoms and clinical findings in HPV-positive and HPV-negative oropharyngeal cancer patients.
    Acta Otolaryngol 2017 Nov 21:1-6. Epub 2017 Nov 21.
    a Department of Otorhinolaryngology - Head and Neck Surgery , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
    Objectives: Oropharyngeal squamous cell carcinoma (OPSCC) is divided in two different disease entities depending on HPV involvement. We investigated differences in presenting symptoms and clinical findings in patients with HPV-positive and -negative OPSCC tumors.

    Methods: Altogether 118 consecutive patients diagnosed with primary OPSCC between 2012 and 2014 at the Helsinki University Hospital were included. Read More

    The Uptake of Human Papillomavirus Vaccination and Its Associated Factors Among Adolescents: A Systematic Review.
    J Prim Care Community Health 2017 Nov 1:2150131917742299. Epub 2017 Nov 1.
    1 The Hong Kong Polytechnic University, Kowloon, Hung Hom, Hong Kong SAR.
    Background: The purpose of this review was to explore the uptake of the human papillomavirus (HPV) vaccination, its associated factors, and the facilitators of and barriers to HPV vaccination among adolescents.

    Methods: A comprehensive literature search was conducted through 5 electronic databases, including PubMed, CINAHL, Cochrane Library, Medline, and PsycInfo from January 2006 to March 2015 for studies examining the uptake, awareness, knowledge, acceptability, and intention of adolescents with regard to HPV vaccination.

    Results: Twenty-eight studies were identified and included. Read More

    Anogenital Human Papillomavirus Infection and HIV Infection Outcomes Among Peruvian Transgender Women: Results from a Cohort Study.
    Transgend Health 2016 1;1(1):94-98. Epub 2016 May 1.
    Medicine Infectious Diseases, University of California, Los Angeles, California.
    Latin American transgender women are highly vulnerable to HIV infection, and although much is known about factors associated with HIV infection in this population, little is known about the association of human papilloma virus (HPV) with HIV infection. We investigated anogenital HPV and cumulative HIV incidence among 68, initially HIV uninfected, Peruvian transgender women enrolled into a 2-year, prospective cohort study: 95.6% had at least one anogenital HPV genotype at baseline, 19. Read More

    Developing a Serious Videogame for Preteens to Motivate HPV Vaccination Decision Making: Land of Secret Gardens.
    Games Health J 2017 Nov 21. Epub 2017 Nov 21.
    3 NC Child Health Research Network, Division of General Pediatrics and Adolescent Medicine, University of North Carolina , Chapel Hill, North Carolina.
    Introduction: Vaccination against human papillomavirus (HPV) is routinely recommended for ages 11-12, yet in 2016 only 49.5% of women and 37.5% of men had completed the three-dose series in the United States. Read More

    Imbalance Between Clinical and Pathologic Staging in the Updated American Joint Commission Cancer Staging System for Human Papillomavirus-Positive Oropharyngeal Cancer.
    J Clin Oncol 2017 Nov 21:JCO2017752063. Epub 2017 Nov 21.
    Carole Fakhry, Johns Hopkins Medicine, Baltimore, MD; Jose P. Zevallos, Washington University School of Medicine in St Louis, St Louis, MO; and David W. Eisele, Johns Hopkins Medicine, Baltimore, MD.

    A systematic review of factors influencing human papillomavirus vaccination among immigrant parents in the United States.
    Health Care Women Int 2017 Nov 21. Epub 2017 Nov 21.
    a University of Connecticut School of Nursing , Storrs , CT , USA.
    To critically appraise factors influencing human papillomavirus (HPV) vaccination among immigrant parents in the United States, a comprehensive search of electronic databases and reference lists was conducted. The findings from 22 articles were ordered based on a socio-ecological model. About 30% of children initiated and 14% completed a 3-dose series. Read More

    Declines in Anogenital Warts Among Age Groups Most Likely to Be Impacted by Human Papillomavirus Vaccination, United States, 2006-2014.
    Am J Public Health 2017 Nov 21:e1-e8. Epub 2017 Nov 21.
    Both authors are with the Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
    Objectives: To detect decreases in anogenital warts (AGW) among sex and age groups likely to be affected by human papillomavirus vaccination.

    Methods: We estimated annual AGW prevalence during 2006 to 2014 using health care claims among US private health insurance enrollees aged 15 to 39 years. We derived AGW diagnoses using 1 of the following: (1) condylomata acuminata diagnosis, (2) viral wart diagnosis combined with a benign anogenital neoplasm diagnosis or destruction or excision of an anogenital lesion, or (3) AGW medication combined with a benign anogenital neoplasm diagnosis or destruction or excision of an anogenital lesion. Read More

    Do Infection Patterns of Human Papillomavirus Affect the Cytologic Detection of High-Grade Cervical Lesions on Papanicolaou Tests?
    Arch Pathol Lab Med 2017 Nov 21. Epub 2017 Nov 21.
    Context: - Persistent infection with high-risk human papillomavirus (hrHPV) is the major cause of cervical cancer. The effect of HPV infection patterns on cytologic detection of cervical lesions is unknown.

    Objective: - To determine the effect of HPV infection patterns on the sensitivity of cytologic detection of high-grade cervical lesions. Read More

    Antibodies against human papillomaviruses as diagnostic and prognostic biomarker in patients with neck squamous cell carcinoma from unknown primary.
    Int J Cancer 2017 Nov 21. Epub 2017 Nov 21.
    Division of Molecular Diagnostics of Oncogenic Infections, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Treatment of patients with neck lymph node metastasis of squamous cell carcinoma (SCC) from unknown primary tumor (NSCCUP) is challenging due to the risk of missing occult tumors or inducing toxicity to unaffected sites. Human papillomavirus (HPV) is a promising biomarker given its causal link to oropharyngeal SCC and superior survival of patients with HPV-driven oropharyngeal SCC and NSCCUP. Identification of HPV-driven NSCCUP could focus diagnostic work-up and treatment on the oropharynx. Read More

    General health-related quality of life scores from head and neck squamous cell carcinoma patients obtained throughout the first year following diagnosis predicted up to 10-year overall survival.
    Eur Arch Otorhinolaryngol 2017 Nov 20. Epub 2017 Nov 20.
    Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Bergen, Norway.
    Objectives: To evaluate the 5- and 10-year survival prediction of health-related quality of life (HRQoL) scores obtained at diagnosis and at 6, 9 and 12 months after diagnosis in a cohort of curable head and neck squamous cell carcinoma (HNSCC) patients.

    Materials And Methods: HNSCC patients (n = 109) reported their HRQoL measured by the EORTC Quality of Life Questionnaire (QLQ) general (C30) questionnaire. At diagnosis, the included patients were below 78 years of age and at diagnosis planned treated with curative intent. Read More

    Synchronous HPV-Related Cancer of Bilateral Tonsils Detected Using Transoral Endoscopic Examination with Narrow-Band Imaging.
    Case Rep Otolaryngol 2017 12;2017:9647010. Epub 2017 Oct 12.
    Department of Otolaryngology-Head and Neck Surgery, Tokai University, Isehara, Japan.
    Background: The incidence of human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) has been rapidly increasing worldwide. HPV is reported in approximately 50% cases of OPSCC in Japan. However, there are few reports of synchronous bilateral HPV-positive tonsillar carcinoma, and, in almost all those cases, carcinoma was detected using positron emission tomography/computed tomography and/or bilateral tonsillectomy. Read More

    Herpes Simplex Virus and Human Papillomavirus Coinfections in Hyperimmunoglobulin E Syndrome Presenting as a Conjunctival Mass Lesion.
    Case Rep Med 2017 12;2017:1650841. Epub 2017 Oct 12.
    Legal Medicine Organization, Rasht, Guilan, Iran.
    Hyperimmunoglobulin E syndrome (HIES) or Job's syndrome is a rare immunodeficiency disease with less than 200 cases reported worldwide, among which few cases are reported with lesions due to herpes simplex virus (HSV) or human papillomavirus (HPV). This case study presents a rare case of HIES with coinfection of HSV and HPV. A 12-year-old boy, previously diagnosed with HIES, presented with a large conjunctival mass lesion. Read More

    Human papillomavirus types from infection to cancer in the anus, according to sex and HIV status: a systematic review and meta-analysis.
    Lancet Infect Dis 2017 Nov 17. Epub 2017 Nov 17.
    International Agency for Research on Cancer, Lyon, France. Electronic address:
    Background: Data on carcinogenicity of human papillomavirus (HPV) types in the anus are needed to inform anal cancer prevention through vaccination and screening. This is particularly the case for people infected with HIV, who are at an increased risk of anal cancer.

    Methods: We did a systematic review of studies published from January, 1986, to July, 2017, in MEDLINE, Embase, and the Cochrane Library on anal HPV infection, without any language restrictions. Read More

    Development of a goat model for evaluation of withaferin A: Cervical implants for the treatment of cervical intraepithelial neoplasia.
    Exp Mol Pathol 2017 Nov 17. Epub 2017 Nov 17.
    James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, United States; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, United States. Electronic address:
    Cervical cancer is caused by human papillomavirus (HPV). The disease develops over many years through a series of precancerous lesions. Cervical cancer can be prevented by HPV-vaccination, screening and treatment of precancer before development of cervical cancer. Read More

    Unequal interactions: Examining the role of patient-centered care in the inequitable diffusion of a medical innovation, the human papillomavirus (HPV) vaccine.
    Soc Sci Med 2017 Oct 9. Epub 2017 Oct 9.
    Division of General Pediatrics, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Enders, 300 Longwood Avenue, Boston, MA 02115, USA; Kaiser Permanente School of Medicine, 100 South Los Robles Avenue, Pasadena, CA 91106, USA. Electronic address:
    Rationale: Studies of inequities in diffusion of medical innovations rarely consider the role of patient-centered care.

    Objective: We used uptake of the human papillomavirus (HPV) vaccine shortly after its licensing to explore the role of patient-centered care.

    Methods: Using a longitudinal multi-site survey of US parents and adolescents, we assessed whether patient-centered care ratings might shape racial/ethnic and socioeconomic gaps at two decision points in the HPV vaccination process: (1) Whether a medical provider recommends the vaccine and (2) whether a parent decides to vaccinate. Read More

    Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador.
    Rev Argent Microbiol 2017 Nov 17. Epub 2017 Nov 17.
    Investigador Asistente CONICET, Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Rivadavia 1917, (C1033AAJ) Caba, Argentina; Laboratorio de Biología Molecular Aplicada, FCEQyN, Universidad Nacional de Misiones, Av. Mariano Moreno 1375, 3300 Posadas, Misiones, Argentina; Yachay EP, Secretaría de Educación Superior, Ciencia, Tecnología e Innovación, 9 de Octubre N22-64 y Ramírez Dávalos, Casa Patrimonial, Ecuador.
    The aim of the present study was to gather information regarding the molecular epidemiology of Human papillomavirus (HPV) and related risk factors in a group of women with low- and high-grade cervical lesions and cancer from the coastal region of Ecuador. In addition, we studied the evolution of HPV variants from the most prevalent types and provided a temporal framework for their emergence, which may help to trace the source of dissemination within the region. We analyzed 166 samples, including 57 CIN1, 95 CIN2/3 and 14 cancer cases. Read More

    Long-term persistence of human papillomavirus in the skin of the glans penis of elderly men above 80 years of age.
    Int J STD AIDS 2017 Jan 1:956462417742319. Epub 2017 Jan 1.
    5 Faculty of Medicine, Department of Urology, Kanazawa University, Kanazawa, Japan.
    Investigations of human papillomavirus (HPV) in the glans penis are scarce, especially with regard to its natural history. To elucidate HPV prevalence among Japanese men attending urological clinics, 798 adult participants were recruited consecutively and stratified into groups by age based on 10-year intervals. The overall HPV prevalence among the participants was 24. Read More

    UHRF1 epigenetically down-regulates UbcH8 to inhibit apoptosis in cervical cancer cells.
    Cell Cycle 2017 Nov 20:1-22. Epub 2017 Nov 20.
    a Cancer Research Center , Shandong University School of Basic Medical Sciences , Jinan , Shandong 250012 , China.
    UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is an important epigenetic regulator that plays a part in DNA methylation, protein methylation and ubiquitination. It is also frequently overexpressed in many types of cancers, including cervical cancer, which is caused by human papillomavirus (HPV). In this study, we showed that UHRF1 was up-regulated in HPV oncogene E7 expressing cells and HPV-positive cervical cancer cells. Read More

    MDM4 genetic variants predict HPV16-positive tumors of patients with squamous cell carcinoma of the oropharynx.
    Oncotarget 2017 Oct 30;8(49):86710-86717. Epub 2017 Sep 30.
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
    The increasing incidence of squamous cell carcinoma of the oropharynx (SCCOP) is majorly attributed to the human papillomavirus (HPV) infection. Both HPV and MDM4 play a critical role in inhibition of p53 activity, thus affecting HPV tumor status of SCCOP. Three polymorphisms in MDM4 were genotyped from blood genomic DNA samples and HPV16 status in tumor specimens was examined. Read More

    Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
    Oncotarget 2017 Oct 21;8(49):86369-86383. Epub 2017 Sep 21.
    Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Human cancer cell lines are the most frequently used preclinical models in the study of cancer biology and the development of therapeutics. Although anatomically diverse, human papillomavirus (HPV)-driven cancers have a common etiology and similar mutations that overlap with but are distinct from those found in HPV-negative cancers. Building on prior studies that have characterized subsets of head and neck squamous cell carcinoma (HNSCC) and cervical squamous cell carcinoma (CESC) cell lines separately, we performed genomic, viral gene expression, and viral integration analyses on 74 cell lines that include all readily-available HPV-positive (9 HNSCC, 8 CESC) and CESC (8 HPV-positive, 2 HPV-negative) cell lines and 55 HPV-negative HNSCC cell lines. Read More

    Methylation of CpG sites in the upstream regulatory region, physical status and mRNA expression of HPV-6 in adult-onset laryngeal papilloma.
    Oncotarget 2017 Oct 3;8(49):85368-85377. Epub 2017 Aug 3.
    Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
    The methylation status of HPV-6 upstream regulatory region (URR) in adult-onset laryngeal papillomatosis (AO-LP) remains unclear. The purpose of this study was to investigate the methylation status of URR and the physical status of HPV-6, as well as the dynamic variations of viral load and mRNA expression in AO-LP. We examined 18 specimens from 11 patients with AO-LP by real-time polymerase chain reaction (PCR), bisulfite-sequencing PCR, and amplification of papilloma oncogene transcripts. Read More

    The human papillomavirus DNA helicase E1 binds, stimulates, and confers processivity to cellular DNA polymerase epsilon.
    Nucleic Acids Res 2017 Nov 16. Epub 2017 Nov 16.
    Departments of Microbiology & Immunology and Biochemistry, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA.
    The papillomavirus (PV) helicase protein E1 recruits components of the cellular DNA replication machinery to the PV replication fork, such as Replication Protein A (RPA), DNA polymerase α-primase (pol α) and topoisomerase I (topo I). Here we show that E1 binds to DNA polymerase ϵ (pol ϵ) and dramatically stimulates the DNA synthesis activity of pol ϵ. This stimulation of pol ϵ by E1 is highly specific and occurs even in the absence of the known pol ϵ cofactors Replication Factor C (RFC), Proliferating Cell Nuclear Antigen (PCNA) and RPA. Read More

    Supraglottic squamous cell carcinomas have distinctive clinical features and prognosis based on subregion.
    PLoS One 2017 20;12(11):e0188322. Epub 2017 Nov 20.
    Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
    Objective: To analyze the clinicopathologic characteristics and prognosis of patients with squamous cell carcinoma localized to different supraglottic subregions.

    Methods: Clinicopathologic data were reviewed retrospectively for 111 patients with supraglottic squamous cell carcinoma who were diagnosed between January 1, 1995 and December 31, 2005 and were initially treated with surgery. DNA from human papillomavirus (HPV) 16 and (or /and) HPV 18 were detected in all the 111 supraglottic carcinoma specimens using in situ hybridization. Read More

    CDC Activities for Improving Implementation of Human Papillomavirus Vaccination, Cervical Cancer Screening, and Surveillance Worldwide.
    Emerg Infect Dis 2017 Dec;23(13)
    Cervical cancer incidence and mortality rates are high, particularly in developing countries. Most cervical cancers can be prevented by human papillomavirus (HPV) vaccination, screening, and timely treatment. The US Centers for Disease Control and Prevention (CDC) provides global technical assistance for implementation and evaluation of HPV vaccination pilot projects and programs and laboratory-related HPV activities to assess HPV vaccines. Read More

    Dynamics of HPV Viral Loads Reflect the Treatment Effect of Photodynamic Therapy in Genital Warts.
    Photodiagnosis Photodyn Ther 2017 Nov 15. Epub 2017 Nov 15.
    Department of Dermatology and Venereology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:
    Background: Photodynamic therapy (PDT) has demonstrated good clinical cure rates and low recurrence rates in the treatment of genital warts. Human papillomavirus (HPV) genotypes and viral load assays can reflect the status of persistent or latent infection and serve as a predictor of infection clearance.

    Methods: Specimens from 41 patients with HPV infection were obtained, and the HPV genotypes and viral load were analyzed using real-time polymerase chain reaction (PCR) assays. Read More

    Significance of bizarre cells in cervical screening liquid-based cytology: A prospective study of 15 cases.
    Cytopathology 2017 Nov 20. Epub 2017 Nov 20.
    Charles University, Medical Faculty and Charles University Hospital Pilsen, Pilsen, Czech Republic.
    Objective: The aim of this study was to assess the significance of bizarre cells (cells of squamous origin with a superficial squamous cell-type cytoplasm and characterised by multinucleation that produces bizarre nuclear shapes) in liquid-based cytology (LBC) Papanicoaou (pap) smears with clinical and histological follow-up correlation.

    Methods: Fifteen patients, all with LBC samples containing bizarre cells, were identified in routine ThinPrep(®) LBC workload. HPV testing was performed in each case using residual LBC material. Read More

    Screening for cervical cancer among HIV-positive and HIV-negative women in Cameroon using simultaneous co-testing with careHPV DNA testing and visual inspection enhanced by digital cervicography: Findings of initial screening and one-year follow-up.
    Gynecol Oncol 2017 Nov 15. Epub 2017 Nov 15.
    University of Massachusetts Medical School, 55 N Lake Avenue, Worcester, MA 01655, United States; Beckman Research Institute of City of Hope, 1500 E Duarte Road, Duarte, CA 91010, United States. Electronic address:
    Objective: The World Health Organization (WHO)'s cervical cancer screening guidelines for limited-resource settings recommend sequential screening followed by same-day treatment under a "screen-and-treat" approach. We aimed to (1) assess feasibility and clinical outcomes of screening HIV-positive and HIV-negative Cameroonian women by pairing visual inspection with acetic acid and Lugol's iodine enhanced by digital cervicography (VIA/VILI-DC) with careHPV, a high-risk human papillomavirus (HR-HPV) nucleic acid test designed for low-resource settings; and (2) determine persistence of HR-HPV infection after one-year follow-up to inform optimal screening, treatment, and follow-up algorithms.

    Methods: We co-tested 913 previously unscreened women aged ≥30years and applied WHO-recommended treatment for all VIA/VILI-DC-positive women. Read More

    Human papillomavirus-associated cutaneous disease burden in human immunodeficiency virus (HIV)-positive patients: the role of human papillomavirus vaccination and a review of the literature.
    Int J Dermatol 2017 Nov 20. Epub 2017 Nov 20.
    Department of Dermatology, Ohio State University, Columbus, OH, USA.
    Human papillomavirus (HPV) infection is related to the development of cutaneous squamous cell carcinoma, oropharyngeal carcinoma, and anogenital malignancies. Patients infected with human immunodeficiency virus (HIV) have impaired cell-mediated immunity, placing them at risk for more prolonged infection with a greater likelihood of disease expression. This presents important implications for screening and treatment of HPV in the HIV patient population. Read More

    Clinical Significance of CD163+ and CD68+ Tumor-associated Macrophages in High-risk HPV-related Cervical Cancer.
    J Cancer 2017 17;8(18):3868-3875. Epub 2017 Oct 17.
    Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University/The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, People's Republic of China.
    Objective. To explore the influence of M2-polarized tumor-associated macrophages (TAMs) on high-risk human papillomavirus (hr-HPV)-related cervical carcinogenesis and metastasis. Methods. Read More

    Role and importance of the expression of transcription factor FOXC2 in cervical cancer.
    Oncol Lett 2017 Dec 20;14(6):6627-6631. Epub 2017 Sep 20.
    Department of Obstetrics, Linyi Hospital of Τraditional Chinese Medicine, Linyi, Shandong 276000, P.R. China.
    The aim of the present study was to investigate the relationship between the expression of transcription factor forkhead box C2 (FOXC2) and the clinical features of cervical cancer. A total of 66 patients with cervical cancer, 42 patients with cervical intraepithelial neoplasia (CIN) and 25 patients with cervical inflammation were enrolled. The positive expression rates and expression levels of mRNA of FOXC2, E-cadherin, N-cadherin, vascular endothelial growth factor (VEGF), stromal cell-derived factor-1 (SDF-1), Notch protein and lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) in cervical tissues were detected using immunohistochemistry and RT-PCR. Read More

    Detection of CTCs in cervical cancer using a conditionally replicative adenovirus targeting telomerase-positive cells.
    Cancer Sci 2017 Nov 19. Epub 2017 Nov 19.
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medicine, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8641, Japan.
    Circulating tumor cells (CTCs) are newly discovered biomarkers of cancers. Although many systems detect CTCs, a gold standard has not yet been established. We analyzed CTCs in uterine cervical cancer patients using an advanced version of conditionally replicative adenovirus targeting telomerase-positive cells, which was enabled to infect coxsackievirus-adenovirus receptor-negative cells and to reduce false-positive signals in myeloid cells. Read More

    Using Facebook to Recruit Young Australian Men Into a Cross-Sectional Human Papillomavirus Study.
    J Med Internet Res 2017 Nov 17;19(11):e389. Epub 2017 Nov 17.
    Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Australia.
    Background: Young men can be difficult to engage in health research using traditional methods of recruitment. Social networking sites are increasingly being used to recruit participants into health research, due to their cost effectiveness, overall generalizability, and wide reach.

    Objective: The aim of this study was to determine the feasibility of using Facebook to recruit young Australian men into a human papillomavirus (HPV) prevalence study. Read More

    Mapping evidence on the distribution of human papillomavirus-related cancers in sub-Saharan Africa: scoping review protocol.
    Syst Rev 2017 Nov 17;6(1):229. Epub 2017 Nov 17.
    Discipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Mazisi Kunene Road, Durban, 4041, South Africa.
    Background: Despite the introduction of HPV vaccines, the incidence of HPV-related cancers (cervical, penile, anal, vulvar, vagina, head, and neck) in sub-Saharan Africa has been rising. The increasing incidence of these HPV-related cancers has been attributed to changes in lifestyle-related risk factors, most notably sexual behavior. The main objective of this study is to map evidence on the distribution of HIV-related cancers in sub-Saharan Africa (SSA). Read More

    Enhancement of therapeutic DNA vaccine potency by melatonin through inhibiting VEGF expression and induction of antitumor immunity mediated by CD8+ T cells.
    Arch Virol 2017 Nov 17. Epub 2017 Nov 17.
    Department of Virology, Pasteur Institute of Iran, P.O. Box: 1316943551, Tehran, Iran.
    To be effective, therapeutic cancer vaccines should stimulate both an effective cell-mediated and a robust cytotoxic CD8+ T-cell response against human papillomavirus (HPV)-infected cells to treat the pre-existing tumors and prevent potential future tumors. In this study, the therapeutic experiments were designed in order to evaluate antitumor effect against the syngeneic TC-1 tumor model. The anti-tumor efficacy of a HPV-16 E7 DNA vaccine adjuvanted with melatonin (MLT) was evaluated in a C57BL/6 mouse tumor model by measuring tumor growth post vaccination and the survival rate of tumor-bearing mice, analyzing the specific lymphocyte proliferation responses in control and vaccinated mice by MTT assay. Read More

    Relative Performance of HPV and Cytology Components of Cotesting in Cervical Screening.
    J Natl Cancer Inst 2017 Nov 14. Epub 2017 Nov 14.
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD; Regional Laboratory, The Permanente Medical Group, Oakland, CA; Information Management Services, Calverton, MD; Albert Einstein College of Medicine, Bronx, NY.
    Background: The main goal of cervical screening programs is to detect and treat precancer before cancer develops. Human papillomavirus (HPV) testing is more sensitive than cytology for detecting precancer. However, reports of rare HPV-negative, cytology-positive cancers are motivating continued use of both tests (cotesting) despite increased testing costs. Read More

    Human papillomavirus (HPV) and somatic EGFR mutations are essential, mutually exclusive oncogenic mechanisms for inverted sinonasal papillomas and associated sinonasal squamous cell carcinomas.
    Ann Oncol 2017 Nov 14. Epub 2017 Nov 14.
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
    Background: Inverted sinonasal papilloma (ISP) is a locally aggressive neoplasm often associated with sinonasal squamous cell carcinoma (SNSCC). While the etiology of ISP is not well understood, human papillomavirus (HPV) has been detected in a subset of cases. Our group recently identified activating somatic EGFR mutations in the majority of ISP and ISP-associated SNSCC. Read More

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