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    Towards quality and order in human papillomavirus research.
    Virology 2018 Apr 18;519:74-76. Epub 2018 Apr 18.
    International HPV Reference Center, Department of Laboratory Medicine, Karolinska Institutet, and Karolinska University Laboratory, Karolinska University Hospital, SE-141 86 Stockholm, Sweden.
    The International Human Papillomavirus (HPV) Reference Center supports quality and order in HPV research and diagnostics. Notably, the center assigns HPV type numbers to novel HPV types, maintains a reference clone repository, and issues international proficiency panels for HPV genotyping. The established HPV types, currently up to HPV225, belong to 5 different genera: alpha (65 types), beta (54 types), gamma (98 types), mu (3 types) and nu (1 type). Read More

    Molecular progression to cervical precancer, epigenetic switch or sequential model?
    Int J Cancer 2018 Apr 21. Epub 2018 Apr 21.
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Bart's and the London School of Medicine, Charterhouse Square, London EC1M 6BQ, UK.
    The evolution of precancerous cervical lesions is poorly understood. A widely held model of cervical intraepithelial neoplasia grade 3 (CIN3) development is sequential progression from normal through CIN1 and CIN2 to CIN3. Another hypothesis, the "molecular switch" model, postulates that CIN3 can evolve directly from human papillomavirus (HPV)-infected normal epithelium without progressing through CIN1 and CIN2. Read More

    Cost Effectiveness of Human Papillomavirus Vaccination for Men Who have Sex with Men; Reviewing the Available Evidence.
    Pharmacoeconomics 2018 Apr 20. Epub 2018 Apr 20.
    Unit of PharmacoTherapy, -Epidemiology & -Economics (PTE2), Department of Pharmacy, University of Groningen, Antonius Deusinglaan 1, Building 3214, 9713 AV, Groningen, The Netherlands.
    Background: Men who have sex with men require special attention for human papillomavirus vaccination given elevated infection risks and the development of, in particular, anal cancer.

    Objective: Our purpose was to review the cost effectiveness of human papillomavirus vaccination for both currently vaccine-eligible and non-eligible individuals, particularly the men-who-have-sex-with-men population, and synthesize the available evidence.

    Methods: We systematically searched for published articles in two main databases (PubMed and EMBASE). Read More

    Parents' uptake of human papillomavirus vaccines for their children: a systematic review and meta-analysis of observational studies.
    BMJ Open 2018 Apr 20;8(4):e019206. Epub 2018 Apr 20.
    Centre for Applied Social Research, Factor-Inwentash Faculty of Social Work, University of Toronto, Toronto, Ontario, Canada.
    Objective: To examine factors associated with parents' uptake of human papillomavirus (HPV) vaccines for their children.

    Design: Systematic review and meta-analysis.

    Data Sources: Cochrane Library, AIDSLINE, CINAHL, EMBASE, PsycINFO, Social Sciences Abstracts, Ovid MEDLINE, Scholars Portal, Social Sciences Citation Index and Dissertation Abstracts International from inception through November 2017. Read More

    Safety and Efficacy of Mesenchymal Stem Cells for Radiation-Induced Xerostomia: A Randomized, Placebo-Controlled Phase 1/2 Trial (MESRIX).
    Int J Radiat Oncol Biol Phys 2018 Mar 6. Epub 2018 Mar 6.
    Department of Otorhinolaryngology-Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
    Background: Salivary gland hypofunction and xerostomia are major complications to head and neck radiotherapy. This trial assessed the safety and efficacy of adipose tissue-derived mesenchymal stem cell (ASC) therapy for radiation-induced xerostomia.

    Patient And Methods: This randomized, placebo-controlled phase 1/2 trial included 30 patients, randomized in a 1:1 ratio to receive ultrasound-guided transplantation of ASCs or placebo to the submandibular glands. Read More

    Validation of a new HPV self-sampling device for cervical cancer screening: The Cervical and Self-Sample In Screening (CASSIS) study.
    Gynecol Oncol 2018 Apr 17. Epub 2018 Apr 17.
    Department of Microbiology, McGill University Health Centre, Montreal, Canada.
    Objective: We compared the self-sampling performance of the newly designed HerSwab™ device with a physician-collected cervical sample and another self-sample using the cobas® PCR Female swab for the detection of cervical intraepithelial neoplasia (CIN) and cancer.

    Methods: Women referred for colposcopy at McGill University affiliated hospital clinics collected two consecutive self-samples, one with HerSwab™ and one with cobas® swab, after receiving instructions. The order of sampling was randomized. Read More

    Viral induced oxidative and inflammatory response in Alzheimer's disease pathogenesis with identification of potential drug candidates: A systematic review using systems biology approach.
    Curr Neuropharmacol 2018 Apr 19. Epub 2018 Apr 19.
    Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Delhi. India.
    Alzheimer's disease (AD) is genetically complex with multifactorial etiology. Here, we aim to identify the potential viral pathogens leading to aberrant inflammatory and oxidative stress response in AD along with potential drug candidates using systems biology approach. We retrieved protein interactions of amyloid precursor protein (APP) and tau protein (MAPT) from NCBI and genes for oxidative stress from NetAge, for inflammation from NetAge and InnateDB databases. Read More

    Streptococcus endopeptidases promote HPV infection in vitro.
    Microbiologyopen 2018 Apr 19:e00628. Epub 2018 Apr 19.
    Department of Oral Biology, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA.
    Both cervical and throat cancers are associated with human papillomavirus (HPV). HPV infection requires cleavage of the minor capsid protein L2 by furin. While furin is present in the vaginal epithelium, it is absent in oral epithelial basal cells where HPV infection occurs. Read More

    Conjunctival papilloma: Clinical features, outcome, and factors related to recurrence.
    Taiwan J Ophthalmol 2018 Jan-Mar;8(1):15-18
    Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.
    Purpose: The purpose of the study was to evaluate the clinical features, treatment, and outcome of patients with conjunctival papilloma.

    Materials And Methods: Twenty-two patients (22 eyes) with biopsy-proven conjunctival papilloma between January 2005 and January 2015 in a tertiary medical center were retrospectively reviewed. Clinical profiles, treatment, outcome, and factors related to recurrence were evaluated. Read More

    Why is announcement training more effective than conversation training for introducing HPV vaccination? A theory-based investigation.
    Implement Sci 2018 Apr 19;13(1):57. Epub 2018 Apr 19.
    Department of Health Behavior, Gillings School of Global Pubic Health, University of North Carolina, CB7440, Chapel Hill, NC, 27599, USA.
    Background: Improving healthcare providers' communication about HPV vaccination is critical to increasing uptake. We previously demonstrated that training providers to use presumptive announcements to introduce HPV vaccination improved uptake, whereas training them to use participatory conversations had no effect. To understand how communication training changed provider perceptions and communication practices, we evaluated intermediate outcomes and process measures from our randomized clinical trial, with a particular focus on identifying mechanisms that might explain the announcement training's impact. Read More

    The Role of miRNAs in Virus-Mediated Oncogenesis.
    Int J Mol Sci 2018 Apr 17;19(4). Epub 2018 Apr 17.
    Department of Genetics and Microbiology, Faculty of Science, Charles University, Průmyslová 595, Vestec, CZ-25250, 128 44 Prague, Czech Republic.
    To date, viruses are reported to be responsible for more than 15% of all tumors worldwide. The oncogenesis could be influenced directly by the activity of viral oncoproteins or by the chronic infection or inflammation. The group of human oncoviruses includes Epstein–Barr virus (EBV), human papillomavirus (HPV), hepatitis B virus (HBV), hepatitis C virus (HCV), human herpesvirus 8 (HHV-8) or polyomaviruses, and transregulating retroviruses such as HIV or HTLV-1. Read More

    Factors Associated with HPV Vaccine Refusal among Young Adult Women after Ten Years of Vaccine Implementation.
    Int J Environ Res Public Health 2018 Apr 17;15(4). Epub 2018 Apr 17.
    Department of Science for Health Promotion and Mother Child Care "G. D'Alessandro", University of Palermo, Via del Vespro 133, 90127 Palermo, Italy.
    In Italy, the Human Papillomavirus (HPV) vaccination was implemented for twelve years old girls in 2007, but its coverage was lower than the recommended level. Sicily is one of the Italian administrative regions with lower vaccination coverage, with a value of 59% for those born in 1996 increasing to 62% coverage for those born in 1999. The aim of the study was to investigate factors associated with the refusal of HPV vaccination among young adult women of Palermo, Italy. Read More

    Comparative Study on Detection and Typing of Human Papillomavirus (HPV) Infection with Microarray Using Paraffin-Embedded Specimens from Squamous Cell Carcinoma and Cervical Precursor Lesions.
    J Nanosci Nanotechnol 2017 Feb;17(2):990-97
    Prevalence and type distribution of human papillomavirus (HPV) in squamous cell carcinoma (SCC) and cervical intraepithelial neoplasia (CIN) were investigated in Jiangsu Province, China. A total of 344 tissue sample cases with cervical squamous-cell carcinoma (SCC) and 135 with CIN I, 117 with CIN II, and 220 with CIN III were obtained from women undergoing biopsy or surgery. 33 samples of normal cervical tissue were collected with biopsy in inspected women. Read More

    Effects of Human Papillomavirus Awareness and Knowledge on Psychological State of Women Referred to Cervical Cancer Screening.
    J Low Genit Tract Dis 2018 Apr 19. Epub 2018 Apr 19.
    Clinical Center of Serbia, Department of Obstetrics and Gynecology, University of Belgrade, Faculty of Medicine, Belgrade, Serbia.
    Objective: The aim of the study was to assess the impact of human papillomavirus (HPV) awareness and knowledge on physiological state and quality of life of women referred to colposcopy and/or HPV testing.

    Materials And Methods: A cross-sectional study was carried out at University Hospital, Belgrade, Serbia. The women with abnormal Pap test results obtained at the primary care centers requiring colposcopy and/or HPV testing were included. Read More

    Cervical Cancer Screening.
    Am Fam Physician 2018 Apr;97(7):441-448
    Carl R. Darnall Army Medical Center, Fort Hood, TX, USA.
    Screening in women has decreased the incidence and mortality of cervical cancer. Precancerous cervical lesions (cervical intraepithelial neoplasias) and cervical carcinomas are strongly associated with sexually-transmitted high-risk human papillomavirus (HPV) infection, which causes more than 99% of cervical cancers. Screening methods include cytology (Papanicolaou test) and HPV testing, alone or in combination. Read More

    Cervical Cancer: Evaluation and Management.
    Am Fam Physician 2018 Apr;97(7):449-454
    University of Kansas School of Medicine-Wichita, Wichita, KS, USA.
    Human papillomavirus infection is the precursor for the development of cervical cancer and is detectable in 99.7% of squamous cell carcinoma and adenocarcinoma cases. Early detection of precancerous lesions with Papanicolaou testing remains the primary mechanism for cancer prevention. Read More

    Vaccinations in pediatric kidney transplant recipients.
    Pediatr Nephrol 2018 Apr 18. Epub 2018 Apr 18.
    Department of Pediatrics, Division of Pediatric Nephrology and Hypertension, Indiana University School of Medicine, 699 Riley Hospital Drive, Riley Research 230, Indianapolis, IN, 46202, USA.
    Pediatric kidney transplant (KT) candidates should be fully immunized according to routine childhood schedules using age-appropriate guidelines. Unfortunately, vaccination rates in KT candidates remain suboptimal. With the exception of influenza vaccine, vaccination after transplantation should be delayed 3-6 months to maximize immunogenicity. Read More

    Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model.
    JCI Insight 2018 Apr 19;3(8). Epub 2018 Apr 19.
    Experimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA.
    T cell receptor (TCR) T cell therapy is a promising cancer treatment modality. However, its successful development for epithelial cancers may depend on the identification of high-avidity TCRs directed against tumor-restricted target antigens. The human papillomavirus (HPV) E7 antigen is an attractive therapeutic target that is constitutively expressed by HPV+ cancers but not by healthy tissues. Read More

    Clearance of human papillomavirus related anal condylomas after oral and endorectal multistrain probiotic supplementation in an HIV positive male: A case report.
    Medicine (Baltimore) 2018 Apr;97(16):e0329
    Department of Public Health and Infectious Diseases.
    Introduction: Here we present the case of a 56-year-old human immunodeficiency virus (HIV)-infected man with multiple anal condylomas and positivity for human papilloma virus (HPV) 18 on anal brushing. Biopsies of the anal mucosa led to the diagnosis of Bowen's disease and a subsequent pelvic magnetic resonance imaging (MRI) scan evidenced multiple reactive lymphoadenopathies and large intra-anal condylomas. The patient was treated with a complete excision of Bowen's lesion and with a 4 months course of supplementation with a high concentration multistrain probiotic formulation administered orally and by rectal instillation with the purpose to reduce local inflammation and to enhance local mucosal immunity. Read More

    Correlation of hTERT Expression with Cervical Cytological Abnormalities and Human Papillomavirus Infection.
    Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):143-151
    Department of Molecular Biology, Genetics and Microbiology, Institute of Biology, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia.
    Telomerase Reverse Transcriptase (TERT) is the main catalytic sub-unit of telomerase, a reverse transcriptase enzyme. Telomerase expression is regulated at many levels, with numerous studies suggesting that up-regulation of human TERT gene (hTERT) at transcriptional level results in immortal cell phenotype associated with cancer. The aim of this study is to determine the correlation between hTERT expression and different cervical precursor lesions, as well as with cervical cancer in patients with confirmed Human papillomavirus (HPV) infection. Read More

    Human papillomavirus: An unlikely etiologic factor in sinonasal inverted papilloma.
    Laryngoscope 2018 Apr 18. Epub 2018 Apr 18.
    Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
    Objectives/hypothesis: Tenuous evidence has supported the hypothesis that sinonasal inverted papilloma (SNIP) arise from human papillomavirus (HPV) infection. To clarify the role of HPV in SNIP, all known HPV sub-types were evaluated by employing a robust polymerase chain reaction-based method in a wide variety of SNIPs from a single institution.

    Study Design: Retrospective surgical specimen tumor sample analysis. Read More

    Cervical cancer - State of the science: From angiogenesis blockade to checkpoint inhibition.
    Gynecol Oncol 2018 Mar 3;148(3):609-621. Epub 2018 Feb 3.
    The Division of Gynecologic Oncology, University of California, Irvine, United States. Electronic address:
    Vascular endothelial growth factor (VEGF) has emerged as a therapeutic target in several malignancies, including cervical cancer. Chemotherapy doublets combined with the fully humanized monoclonal antibody, bevacizumab, now constitute first-line therapy for women struggling with recurrent/metastatic cervical carcinoma. Regulatory approval for this indication was based on the phase III randomized trial, GOG 240, which demonstrated a statistically significant and clinically meaningful improvement in overall survival when bevacizumab was added to chemotherapy: 17. Read More

    Awareness of cervical cancer and willingness to be vaccinated against human papillomavirus in Mozambican adolescent girls.
    Papillomavirus Res 2018 Apr 14. Epub 2018 Apr 14.
    Centro de Investigação em Saúde de Manhiça (CISM). Rua 12, Cambeve CP 1929 Maputo, Mozambique; Faculdade de Medicina, Universidade Eduardo Mondlane. AV. Salvador Allende 702 Maputo, Mozambique.
    Sub-Saharan Africa concentrates the largest burden of cervical cancer worldwide. The introduction of the HPV vaccination in this region is urgent and strategic to meet global health targets. This was a cross-sectional study conducted in Mozambique prior to the first round of the HPV vaccine demonstration programme. Read More

    Human papillomavirus vaccine and demyelinating diseases-A systematic review and meta-analysis.
    Pharmacol Res 2018 Apr 14. Epub 2018 Apr 14.
    University Bordeaux, Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology, UMR 1219, F-33000 Bordeaux, France.
    Background: Approved in 2006, human papillomavirus (HPV) vaccines were initially targeted for girls aged 9-14 years. Although the safety of these vaccines has been monitored through post-licensure surveillance programmes, cases of neurological events have been reported worldwide.

    Purpose: The present study aimed to assess the risk of developing demyelination after HPV immunization by meta-analysing risk estimates from pharmacoepidemiologic studies. Read More

    HPV-relatedness definitions for classifying HPV-related oropharyngeal cancer patient do impact on TNM classification and patients' survival.
    PLoS One 2018 17;13(4):e0194107. Epub 2018 Apr 17.
    University of Barcelona, Barcelona, Spain.
    Background: Given the different nature and better outcomes of oropharyngeal carcinoma (OPC) associated with human papillomavirus (HPV) infection, a novel clinical stage classification for HPV-related OPC has been accepted for the 8th edition AJCC TNM (ICON-S model). However, it is still unclear the HPV-relatedness definition with best diagnostic accuracy and prognostic value.

    Material And Methods: The aim of this study was to compare different staging system models proposed for HPV-related OPC patients: 7th edition AJCC TNM, RPA stage with non-anatomic factors (Princess Margaret), RPA with N categories for nasopharyngeal cancer (MD-Anderson) and AHR-new (ICON-S), according to different HPV-relatedness definitions: HPV-DNA detection plus an additional positive marker (p16INK4a or HPV-mRNA), p16INK4a positivity alone or the combination of HPV-DNA/p16INK4a positivity as diagnostic tests. Read More

    Epstein-Barr virus, high-risk human papillomavirus and abnormal cervical cytology in a prospective cohort of African female sex workers.
    Sex Transm Dis 2018 Apr 17. Epub 2018 Apr 17.
    Lineberger Comprehensive Cancer Center, Chapel Hill, NC.
    Background: High oncogenic-risk human papillomavirus (hrHPV) is necessary, although insufficient, to promote cervical cancer. Like HPV, Epstein-Barr virus (EBV) is a common pathogen with the capacity to promote epithelial neoplasms. We examined the association between cervical EBV, hrHPV, and cytology in female sex workers in Nairobi, Kenya. Read More

    Limited Role of Promoter Methylation of and in Triage of Low-Grade Squamous Intraepithelial Lesion.
    Chin Med J (Engl) 2018 Apr;131(8):939-944
    Department of Gynecological Oncology, International Peace Maternity and Child Health Hospital of China Welfare Institute, Shanghai 200030, China.
    Background: Promoter methylation of MGMT and C13ORF18 has been confirmed as a potential biomarker for early diagnosis of cervical cancer. The aim of this study was to evaluate the performance of MGMT and C13ORF18 promoter methylation for triage of cytology screening samples and explore the potential mechanism.

    Methods: Methylation-sensitive high-resolution melting was used to detect promoter methylation of MGMT and C13ORF18 in 124 cervical samples. Read More

    HPV16 increases the number of migratory cancer stem cells and modulates their miRNA expression profile in oropharyngeal cancer.
    Int J Cancer 2018 Apr 16. Epub 2018 Apr 16.
    Institute of Virology, University of Cologne, Cologne, Germany.
    Human papillomavirus type 16 (HPV16) is a major risk for development of oropharyngeal squamous-cell-carcinoma (OPSCC). Although HPV OPSCC metastasize faster than HPV tumors, they have a better prognosis. The molecular and cellular alterations underlying this pathobiology of HPV OPSCC remain elusive. Read More

    WNT ligands control initiation and progression of human papillomavirus-driven squamous cell carcinoma.
    Oncogene 2018 Apr 17. Epub 2018 Apr 17.
    Institute of Experimental Immunology, University of Zürich, 8057, Zurich, Switzerland.
    Human papillomavirus (HPV)-driven cutaneous squamous cell carcinoma (cSCC) is the most common cancer in immunosuppressed patients. Despite indications suggesting that HPV promotes genomic instability during cSCC development, the molecular pathways underpinning HPV-driven cSCC development remain unknown. We compared the transcriptome of HPV-driven mouse cSCC with normal skin and observed higher amounts of transcripts for Porcupine and WNT ligands in cSCC, suggesting a role for WNT signaling in cSCC progression. Read More

    A quantitative LumiFluo assay to test inhibitory compounds blocking p53 degradation induced by human papillomavirus oncoprotein E6 in living cells.
    Sci Rep 2018 Apr 16;8(1):6020. Epub 2018 Apr 16.
    Department of Molecular Medicine, University of Padua, Padua, Italy.
    High-risk human papillomaviruses (HR-HPVs) are the causative agents for the onset of several epithelial cancers in humans. The deregulated expression of the viral oncoproteins E6 and E7 is the driving force sustaining the progression of malignant transformation in pre-neoplastic lesions. Targeting the viral E6 oncoprotein through inhibitory compounds can counteract the survival of cancer cells due to the reactivation of p53-mediated pathways and represents an intriguing strategy to treat HPV-associated neoplasias. Read More

    Importin-β and exportin-5 are indicators of acute viral infection: Correlation of their detection with commercially available detection kits.
    Ann Diagn Pathol 2018 Jan 10;34:36-41. Epub 2018 Jan 10.
    Evandro Chagas National Institute of Infectious Diseases, and Laboratory of Interdisciplinary Medical Research (LIPMED), IOC, Rio de Janeiro, Brazil.
    This work focused on immunohistochemistry markers of acute viral infections. Viral infected cells were detected by in situ based methods (reovirus, rabies virus) or cytologic changes (human papillomavirus, molloscum contagiosum virus, herpes simplex virus). Two proteins involved in nuclear trafficking, importin-β and exportin-5, were detected in the infected cells for each virus and not in the control tissues. Read More

    Comparison of HPV genotyping and cytology triage, COMPACT-Study: Design, methods and baseline results in 14,642 women.
    Cancer Sci 2018 Apr 16. Epub 2018 Apr 16.
    Department of Women's Health Medicine, Hokkaido University, Faculty of Medicine, Sapporo, Japan.
    While cytology-based screening programs have significantly reduced mortality and morbidity from cervical cancer, the global consensus is that primary human papillomavirus (HPV) testing for cervical screening increases detection of high-grade cervical intraepithelial neoplasia (CIN) and invasive cancer. However, the optimal triage strategy for HPV-positive women to avoid over-referral to colposcopy may be setting specific. Since Japan requires data that has been generated domestically to modify screening guidelines, we conducted a 3-year prospective study COMparison of HPV genotyping And Cytology Triage (COMPACT) to evaluate the potential role of HPV16/18 partial genotyping and cytology for primary HPV screening, Totally, 14,642 women aged 20-69yrs undergoing routine screening at three centers in Hokkaido were enrolled. Read More

    Prevalence of mucosal and cutaneous human papillomavirus in Moroccan breast cancer.
    Papillomavirus Res 2018 Apr 13;5:150-155. Epub 2018 Apr 13.
    Oncovirology Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco. Electronic address:
    Background: Due to recent technical improvements and some encouraging new results, there has been a resurgence of interest in the possibility that a substantial proportion of breast cancers (BCs) may be caused by viral infections, including Human papillomavirus (HPV). The aim of this study was to determine the prevalence of mucosal and cutaneous HPV in tumours from Moroccan BC patients.

    Materials And Methods: Frozen tumours from 76 BC cases and 12 controls were evaluated for the presence of 62 HPV-types using highly sensitive assays that combine multiplex polymerase chain reaction and bead-based Luminex technology. Read More

    Automated Cervical Screening and Triage, Based on HPV Testing and Computer-Interpreted Cytology.
    J Natl Cancer Inst 2018 Apr 11. Epub 2018 Apr 11.
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.
    Background: State-of-the-art cervical cancer prevention includes human papillomavirus (HPV) vaccination among adolescents and screening/treatment of cervical precancer (CIN3/AIS and, less strictly, CIN2) among adults. HPV testing provides sensitive detection of precancer but, to reduce overtreatment, secondary "triage" is needed to predict women at highest risk. Those with the highest-risk HPV types or abnormal cytology are commonly referred to colposcopy; however, expert cytology services are critically lacking in many regions. Read More

    Performance of Anal Cytology Compared With High-Resolution Anoscopy and Histology in Women With Lower Anogenital Tract Neoplasia.
    Clin Infect Dis 2018 Apr 5. Epub 2018 Apr 5.
    Homerton Anal Neoplasia Service (HANS), Homerton University Hospital, London, UK.
    Background: Information on the performance of anal cytology in women who are high-risk for human papillomavirus-related lesions and the factors that might influence it are largely lacking.

    Aims: Evaluate the performance of anal cytology in women with lower anogenital tract neoplasia.

    Methods: retrospective study including all new referrals of women with a previous history of anogenital neoplasia, from January 2012 to July 2017, with concomitant anal cytology and high-resolution anoscopy with or without biopsies. Read More

    A randomized, placebo-controlled trial of the quadrivalent HPV vaccine in HIV-infected adults age 27 years or older: AIDS Clinical Trials Group protocol A5298.
    Clin Infect Dis 2018 Apr 5. Epub 2018 Apr 5.
    Department of Medicine University of Pittsburgh Pittsburgh, Pennsylvania, United States.
    Background: Adults living with HIV are at increased risk for anal and oropharyngeal cancer caused by human papillomavirus (HPV). The efficacy of HPV vaccines in this population is unknown.

    Methods: Phase 3, double-blind, randomized controlled trial. Read More

    The clinical value of HPV E6/E7 and STAT3 mRNA detection in cervical cancer screening.
    Pathol Res Pract 2018 Feb 11. Epub 2018 Feb 11.
    Department of Obstetrics and Gynecology, The Fifth Clinical Medical College of Yangzhou University, The Second People's Hospital of Changshu City, Suzhou 215006, China. Electronic address:
    Objective: To explore the value of human papillomavirus (HPV) E6/E7 and signal transducer and activator of transcription 3 (STAT3) mRNA detection in the screening of cervical lesions.

    Methods: 192 patients with abnormal ThinPrep cytology test (TCT) results and/or high-risk HPV infection were screened to identify possible cervical lesions in cases. Diagnoses were confirmed by histopathology. Read More

    Optical techniques for the diagnosis and treatment of lesions induced by the human papillomavirus - A resource letter.
    Photodiagnosis Photodyn Ther 2018 Apr 11. Epub 2018 Apr 11.
    São Carlos Institute of Physics, University of São Paulo, PO Box 369, 13566-970, São Carlos, SP, Brazil; Federal Institute of Alagoas, Campus Piranhas, Av. Sergipe S/N, 57460-000, Piranhas, AL, Brazil; Institute of Geosciences and Exact Sciences, São Paulo State University "Julio de Mesquita Filho", Av. 24-A 1515, 13506-900, Rio Claro, SP, Brazil.
    Human papillomaviruses (HPV) are the most common sexually-transmitted virus, and carcinogenic HPV strains are reported to be responsible for virtually all cases of cervical cancer and its precursor, the cervical intraepithelial neoplasia (CIN). About 30% of the sexually active population are considered to be affected by HPV. Around 600 million people are estimated to be infected worldwide. Read More

    100 years of STIs in the UK: a review of national surveillance data.
    Sex Transm Infect 2018 Apr 13. Epub 2018 Apr 13.
    Public Health England, London, UK.
    Objectives: The 1916 Royal Commission on Venereal Diseases was established in response to epidemics of syphilis and gonorrhoea in the UK. In the 100 years since the Venereal Diseases Act (1917), the UK has experienced substantial scientific, economic and demographic changes. We describe historical and recent trends in STIs in the UK. Read More

    BET bromodomain inhibitors show anti-papillomavirus activity in vitro and block CRPV wart growth in vivo.
    Antiviral Res 2018 Apr 10. Epub 2018 Apr 10.
    The Jake Gittlen Cancer Research Foundation, H069, Department of Pathology, C7800, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033-0850, USA.
    The DNA papillomaviruses infect squamous epithelium and can cause persistent, benign and sometimes malignant hyperproliferative lesions. Effective antiviral drugs to treat human papillomavirus (HPV) infection are lacking and here we investigate the anti-papillomavirus activity of novel epigenetic targeting drugs, BET bromodomain inhibitors. Bromodomain and Extra-Terminal domain (BET) proteins are host proteins which regulate gene transcription, they bind acetylated lysine residues in histones and non-histone proteins via bromodomains, functioning as scaffold proteins in the formation of transcriptional complexes at gene regulatory regions. Read More

    [HPV vaccine implementation in Chile: an appraisal from the social determinants of health model].
    Rev Med Chil 2017 Dec;145(12):1605-1609
    Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.
    Cervical cancer is the fourth most common neoplasm in women worldwide and its incidence is associated with profound social inequities. In Chile, it is the second cause of death in women of reproductive age. The Chilean clinical guideline identifies the vaccine against Human Papillomavirus (HPV) as the main preventive measure. Read More

    Dose-Modifying Factor of Radiation Therapy with Concurrent Cisplatin Treatment in HPV-Positive Squamous Cell Carcinoma: A Preclinical Study.
    Radiat Res 2018 Apr 13. Epub 2018 Apr 13.
    Department of a   Experimental Oncology, Institute of Oncology Ljubljana, 1000 Ljubljana, Slovenia.
    Human papillomavirus (HPV) is an important etiological factor in oropharyngeal squamous cell carcinoma (SCC). Compared to HPV-negative tumors, HPV-positive oropharyngeal SCC has shown a better response to nonsurgical treatments. In this study, we determined the dose-modifying factors for HPV-positive tumors with single-dose irradiation, with or without low radiosensitizing doses of cisplatin. Read More

    HPV Screening and Vaccination Strategies in an Unscreened Population: A Mathematical Modeling Study.
    Bull Math Biol 2018 Apr 12. Epub 2018 Apr 12.
    Centre for Disease Modelling, Department of Mathematics and Statistics, York University, Toronto, Canada.
    Human papillomavirus (HPV), a sexually transmitted infection, is the necessary cause of cervical cancer, the third most common cancer affecting women worldwide. Prevention and control strategies include vaccination, screening, and treatment. While HPV prevention and control efforts are important worldwide, they are especially important in low-income areas with a high infection rate or high rate of cervical cancer. Read More

    [The Combination of Molecular Targeted Agents with Radiotherapy in Head and Neck Cancer].
    Gan To Kagaku Ryoho 2018 Mar;45(3):419-423
    Division of Gastrointestinal Oncology, Shizuoka Cancer Center.
    Concurrent cisplatin based chemoradiotherapy(CRT)is the standard of care for patients with locoregionally advanced squamous cell carcinoma of the head and neck(LA-SCCHN). Based on the Bonner trial showing the superiority of cetuximab plus radiotherapy to radiotherapy alone, cetuximab based bioradiotherapy(BRT)is considered as an alternative for patients with LA-SCCHN. However, the non-inferiority of BRT compared to CRT has not yet been demonstrated. Read More

    Human papillomavirus vaccination coverage among females and males, National Health and Nutrition Examination Survey, United States, 2007-2016.
    Vaccine 2018 Apr 9. Epub 2018 Apr 9.
    Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30329-4027, USA.
    Background: Human papillomavirus (HPV) vaccination has been routinely recommended at age 11-12 years in the United States for females since 2006 and males since 2011. Coverage can be estimated using self/parent-reported HPV vaccination collected in the National Health and Nutrition Examination Survey (NHANES) for a wider age range than other national surveys. We assessed vaccination coverage in 2015-2016, temporal trends by age, and the validity of self/parent-reported vaccination status. Read More

    Women's knowledge, beliefs, and behaviors toward the prevention of human papillomavirus transmission.
    Enferm Clin 2018 Feb;28 Suppl 1:191-194
    Faculty of Nursing, Universitas Indonesia, Depok, Jawa Barat, Indonesia.
    Objective: To identify the relationship between women's knowledge, beliefs, and behaviors and human papillomavirus (HPV) transmission prevention.

    Method: This was a cross-sectional study with a convenience sampling technique. The samples were from 649 women of reproductive age who either were married or who had once been married. Read More

    Barriers to cervical screening and interest in self-sampling among women who actively decline screening.
    J Med Screen 2018 Jan 1:969141318767471. Epub 2018 Jan 1.
    1 Cancer Communication and Screening Group, Department of Behavioural Science and Health, 4919 UCL , London, UK.
    Objectives Understanding why some women actively decline cervical screening could contribute to tailored intervention development. We explored reasons for non-participation in cervical screening among women who had made an active decision not to attend in the future. We also explored interest in human papillomavirus self-sampling. Read More

    Human papillomavirus infection prevalence in female university students in Novi Sad, Serbia.
    Srp Arh Celok Lek 2016 May-Jun;144(5-6):300-6
    Introduction: Cervical cancer, attributed to human papillomavirus (HPV) infection, represents the fourth most common and lethal cancer in Serbian women, and the second most common cancer in women aged 15–44.

    Objective: The aim of the study was to determine the presence of high-risk and low-risk HPV types in population of unvaccinated female university students in Novi Sad, Serbia, and to evaluate possible risk factors for HPV infection.

    Methods: Sample consisted of 250 young women (19–26 years of age) attending outpatient clinics for screening gynecological examination. Read More

    CHAPTER 8 HPV vaccines.
    Int J Gynaecol Obstet 2006 Nov;94 Suppl 1:S81-S88
    Vaccines to prevent infection with high-risk human papillomaviruses (HPV) will help protect women against cervical cancer, and some are likely to be available within the next year. One vaccine, a quadrivalent vaccine against HPV types 6, 11, 16 and 18 and known as Garadsil ©(Merck &Co., Inc), was approved by the Federal Drug Administration (FDA) for the prevention of cervical cancer, cervical cancer precursors and vulval and vaginal cancer precursors associated with HPV 16 and 18 in June 2006. Read More

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