49,069 results match your criteria Human Papillomavirus


Identification of European-wide clinical priorities for guideline development in the management of pre-invasive cervical disease.

Eur J Obstet Gynecol Reprod Biol 2020 May 19;251:36-41. Epub 2020 May 19.

Department of Gynaecological Oncology, University Hospitals of North Midlands, Newcastle Road, Stoke on Trent, ST4 6QG, UK. Electronic address:

Objective: Addressing management controversies in the treatment of pre-invasive cervical disease is a key priority for the European Federation for Colposcopy/European Society of Gynaecologic Oncology who aim to develop a practical handbook of European centred guidelines to address areas where there is a lack of high-quality evidence or identifiable practice variation. Clinical opinion across the EFC network was sought to identify topics likely to have the most impact on clinical practice for systematic review and development of practice recommendations.

Study Design: A scoping exercise comprising of a three-iteration modified Delphi with representation from each member society of the EFC was conducted in 2018. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.017DOI Listing

Beyond HIV infection: neglected and varied impacts of CCR5 and CCR5Δ32 on viral diseases.

Virus Res 2020 May 29:198040. Epub 2020 May 29.

Laboratório de Imunobiologia e Imunogenética, Departamento de Genética, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, Brazil; Programa de Pós-Graduação em Genética e Biologia Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, Brazil; Núcleo de Bioinformática do Laboratório de Imunobiologia e Imunogenética, Departamento de Genética, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, Brazil. Electronic address:

The interactions between chemokine receptors and their ligands may affect susceptibility to infectious diseases as well as their clinical manifestations. These interactions mediate both the traffic of inflammatory cells and virus-associated immune responses. In the context of viral infections, the human C-C chemokine receptor type 5 (CCR5) receives great attention from the scientific community due to its role as an HIV-1 co-receptor. Read More

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http://dx.doi.org/10.1016/j.virusres.2020.198040DOI Listing

Safety and Efficacy of Pembrolizumab With Chemoradiotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase IB Study.

J Clin Oncol 2020 Jun 1:JCO1903156. Epub 2020 Jun 1.

Sanford Cancer Center, Sanford Health, Sioux Falls, SD.

Purpose: Pembrolizumab is a humanized monoclonal antibody that blocks interaction between programmed death receptor-1 (PD-1) and its ligands (PD-L1, PD-L2). Although pembrolizumab is approved for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC), its role in the management of locally advanced (LA) disease is not defined. We report a phase IB study evaluating the safety and efficacy of adding pembrolizumab to cisplatin-based chemoradiotherapy in patients with LA HNSCC. Read More

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http://dx.doi.org/10.1200/JCO.19.03156DOI Listing

Hypofractionated radiotherapy alone with 2.4 Gy per fraction for head and neck cancer during the COVID-19 pandemic: The Princess Margaret experience and proposal.

Cancer 2020 Jun 1. Epub 2020 Jun 1.

Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada.

Background: The objective of this study was to identify a subgroup of patients with head and neck squamous cell carcinoma (HNSCC) who might be suitable for hypofractionated radiotherapy (RT-hypo) during the COVID-19 pandemic.

Methods: HNSCC cases (oropharynx/larynx/hypopharynx) treated with definitive RT-hypo (60 Gy in 25 fractions over 5 weeks), moderately accelerated radiotherapy (RT-acc) alone (70 Gy in 35 fractions over 6 weeks), or concurrent chemoradiotherapy (CCRT) during 2005-2017 were included. Locoregional control (LRC) and distant control (DC) after RT-hypo, RT-acc, and CCRT were compared for various subgroups. Read More

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http://dx.doi.org/10.1002/cncr.32968DOI Listing

Examining Potential Usability and Health Beliefs Among Young Adults Using a Conversational Agent for HPV Vaccine Counseling.

AMIA Jt Summits Transl Sci Proc 2020 30;2020:43-52. Epub 2020 May 30.

The University of Texas Health Science Center at Houston, Houston, TX.

The human papillomavirus (HPV) vaccine is the most effective way to prevent HPV-related cancers. Integrating provider vaccine counseling is crucial to improving HPV vaccine completion rates. Automating the counseling experience through a conversational agent could help improve HPV vaccine coverage and reduce the burden of vaccine counseling for providers. Read More

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Risk of cervical lesions in high-risk HPV positive women with normal cytology: a retrospective single-center study in China.

Infect Agent Cancer 2020 21;15:34. Epub 2020 May 21.

1Department of Gynecology, Qilu Hospital of Shandong University, Jinan, China.

Background: To investigate high-risk HPV (hr-HPV) genotype distributions and the association between hr-HPV infection with severity of the cervical lesions in women with normal cytology.

Methods: In this cross-sectional study, the result of the hr-HPV test and biopsy of colposcopy of women with normal cytology from January 2012 to January 2019 were analyzed. The detection rate of high-grade squamous intraepithelial lesion (HSIL) and cervical cancer were calculated among different hr-HPV genotypes, viral load group, and age groups. Read More

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http://dx.doi.org/10.1186/s13027-020-00291-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240930PMC

[Viral co-infection with head and neck tumors].

Vestn Otorinolaringol 2020 ;85(2):67-72

Tomsk National Research Medical Center of the Russian Academy of Sciences, Oncology Research Institute, Tomsk, Russia.

The review is devoted to assessing the prevalence of human papillomavirus (HPV) in combination with other viral agents for head and neck tumors (HNT). HPV is recognized as an etiological factor in the development of cervical cancer, but there is evidence that it may be involved in carcinogenesis in other locations, in particular the upper respiratory tract. However, HPV is not the most important factor in tumor growth and progression. Read More

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http://dx.doi.org/10.17116/otorino20208502167DOI Listing
January 2020

HPV detection rates and histopathologic follow-up of patients with HSIL cytology in a large academic women's hospital laboratory.

J Am Soc Cytopathol 2020 May 6. Epub 2020 May 6.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address:

Introduction: High risk (hr) human papillomavirus (HPV) testing has been proposed as a possible replacement for Papanicolaou (Pap) cytology for cervical screening. The aim of the present study was to assess the hrHPV detection rates using 3 available Food and Drug Administration-approved HPV assays in patients with high-grade squamous intraepithelial lesion (HSIL) cytology results and to correlate the cervical screening test results with the immediate histopathologic findings.

Materials And Methods: Cases with positive HSIL ThinPrep cytology findings, concurrent hrHPV testing results, and histopathologic follow-up results obtained within 6 months of the Pap/HPV co-testing were identified from July 2010 to April 2018. Read More

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http://dx.doi.org/10.1016/j.jasc.2020.04.010DOI Listing

Stigma as a Barrier to Care for Human Papillomavirus: A Commentary Summarizing Literature and Presenting Recommendations for Health Care Providers.

J Obstet Gynaecol Can 2020 May 28. Epub 2020 May 28.

Society of Obstetricians and Gynaecologists of Canada, Ottawa, ON; Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON; Department of Obstetrics and Gynaecology, University of Ottawa, Ottawa, ON.

In this commentary, we briefly summarize knowledge on stigma associated with human papillomavirus (HPV). In addition, we provide suggestions for health care providers to de-stigmatize HPV and improve the delivery of care. Read More

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http://dx.doi.org/10.1016/j.jogc.2020.02.116DOI Listing

Molecular and pathological basis of HPV-negative cervical adenocarcinoma seen in a global study.

Int J Cancer 2020 May 31. Epub 2020 May 31.

DDL diagnostic Laboratory, Rijswijk, The Netherlands.

International surveys find HPV-negativity in up to 30% of cervical adenocarcinomas. We investigated the pathological diagnosis by expert consensus with immunohistochemistry and presence of somatic mutations in recognised tumour genes in HPV-positive and negative cervical adenocarcinomas (CADC). A sample was selected of 45 paraffin-embedded cervical blocks diagnosed locally as usual cervical adenocarcinoma from a global study. Read More

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http://dx.doi.org/10.1002/ijc.33124DOI Listing

Post-approval Safety Monitoring of Quadrivalent and Bivalent Human Papillomavirus Vaccines Based on Real-world Data from the Korea Adverse Events Reporting System (KAERS).

Clin Drug Investig 2020 May 30. Epub 2020 May 30.

School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, South Korea.

Background And Objectives: The vaccine adjuvant, AS04, present in bivalent human papilloma virus (bHPV) vaccines, induces greater local immune responses than the aluminum adjuvant in quadrivalent HPV (qHPV) vaccines. These distinctions might also result in disparities in immunogenicity and responsiveness, possibly contributing to differences in adverse events (AEs) between these vaccines. Here we comparatively analyzed AEs between qHPV and bHPV vaccines based on 10-year real-world AE data. Read More

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http://dx.doi.org/10.1007/s40261-020-00930-6DOI Listing

LINC00173.v1 promotes angiogenesis and progression of lung squamous cell carcinoma by sponging miR-511-5p to regulate VEGFA expression.

Mol Cancer 2020 May 30;19(1):98. Epub 2020 May 30.

Clinical Experimental Center, Jiangmen Key Laboratory of Clinical Biobanks and Translational Research, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, 529030, China.

Background: Anti-angiogenic therapy represents a promising strategy for non-small-cell lung cancer (NSCLC) but its application in lung squamous cell carcinoma (SQC) is limited due to the high-risk adverse effects. Accumulating evidence indicates that long noncoding RNAs (lncRNAs) mediate in tumor progression by participating in the regulation of VEGF in NSCLC, which might guide the development of new antiangiogenic strategies.

Methods: Differential lncRNA expression in SQC was analyzed in AE-meta and TCGA datasets, and further confirmed in lung cancer tissues and adjacent normal tissues with RT-qPCR and in-situ hybridization. Read More

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http://dx.doi.org/10.1186/s12943-020-01217-2DOI Listing

Application of 5-aminolevulinic acid photodynamic therapy for vaginal intraepithelial neoplasia, a report of six cases.

Photodiagnosis Photodyn Ther 2020 May 27:101837. Epub 2020 May 27.

Department of Gynecology, Affiliated Hospital of Qingdao University, Qingdao 266003, China. Electronic address:

Background: Vaginal intraepithelial neoplasia (VAIN) has a high-risk for recurrence and may precede genital cancers, such as vaginal cancer and/or other invasive diseases. Human papillomavirus (HPV)-induced VAIN may occur after loop electrosurgical excision procedures (LEEPs) or panhysterectomy. Nonetheless, 5-aminolevulinic acid (ALA) photodynamic therapy (ALA-PDT) has demonstrated utility in preventing the recurrence of cervical intraepithelial neoplasia (CIN); however, evaluation of its effect on VAIN has not been performed. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101837DOI Listing

Social media engagement association with human papillomavirus and vaccine awareness and perceptions: Results from the 2017 US Health Information National Trends Survey.

Prev Med 2020 May 27:106151. Epub 2020 May 27.

Department of Community Health and Prevention, Dornsife School of Public Health, Drexel University, Philadelphia, PA, United States of America.

Due to social media's ability to publicize misinformation about vaccines, there is a need to study associations between social media engagement (SME) with human papillomavirus (HPV) and vaccine-related awareness and beliefs. Therefore, the study objectives were to (1) describe the SME of a nationally representative sample of US adults, and (2) determine the associations between SME and HPV-related awareness, HPV-related knowledge, HPV vaccine-related awareness, and perceived HPV vaccine efficacy. In 2019, we completed a secondary analysis of the 2017 Health Information National Trends Survey (Cycle 5. Read More

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http://dx.doi.org/10.1016/j.ypmed.2020.106151DOI Listing

Acceptability of vaccination against human papillomavirus among women aged 20 to 45 in rural Hunan Province, China: A cross-sectional study.

Vaccine 2020 May 26. Epub 2020 May 26.

Xiangya Nursing School of Central South University, Changsha, PR China. Electronic address:

Objective: This study aimed to examine the intentions of and barriers to vaccination against human papillomavirus (HPV) among women aged 20 to 45 in rural areas, and to determine the popular sources to getting information about HPV vaccine and vaccination.

Methods: This cross-sectional study was conducted in 2018 with a sample of women aged 20 to 45 from rural areas of Hunan Province in China. Anonymous self-administered questionnaires were used to collect sociodemographic information and characteristics related to reproductive health of participants, and intentions of and barriers to HPV vaccination. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.05.017DOI Listing

Evaluation of folate receptor-mediated tumor detection as a triage tool in cervical cancer screening.

Int J Gynaecol Obstet 2020 May 29. Epub 2020 May 29.

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.

Objective: To evaluate the efficacy of folate receptor-mediated tumor detection (FRD) for identifying high-grade intraepithelial squamous lesions (HSIL) in the triage of women who are positive for human papillomavirus (HPV), and those with cytology findings of atypical squamous cells of undetermined significance (ASCUS).

Method: A secondary analysis of prospectively collected data from 1504 women who had abnormal results during primary cervical cancer screening at 13 hospitals in Beijing, China, between November 2014 and August 2015. The detection accuracy of FRD was evaluated among HPV-positive women and women with ASCUS referred for colposcopy examination. Read More

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http://dx.doi.org/10.1002/ijgo.13245DOI Listing

Cervical human papillomavirus DNA detection in women living with HIV and HIV-uninfected women living in Limbe, Cameroon.

J Clin Virol 2020 May 19;128:104445. Epub 2020 May 19.

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address:

Background: There are limited data on cervical HPV prevalence in Cameroon and none from its Anglophone region. We investigated cervical HPV prevalence in HIV-uninfected (HIV[-]) and HIV-infected (WLWH) women living in the region.

Methods: A convenience sample of consecutively recruited HIV[-] women (n = 295) and women living with HIV (WLWH) (n = 560) attending the Limbé Regional Hospital were enrolled into a cervical screening study. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104445DOI Listing

SMFM Patient Safety Guideline: Reducing the risk of transmitting infection by transvaginal ultrasound examination.

Am J Obstet Gynecol 2020 May 26. Epub 2020 May 26.

Recent surveys have shown widespread lapses in the procedures used to reduce the risk of transmitting infection via medical devices. Transvaginal ultrasound examination has the potential to transmit vaginal infections, including human papillomavirus (HPV). Areas of particular concern are the use of probe covers with high rates of leakage, use of disinfectants that are not effective against HPV, and use of coupling gel from multiple-use containers. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.05.043DOI Listing

Development and Validation of a Natural Language Processing Algorithm for Surveillance of Cervical and Anal Cancer and Precancer: A Split-validation Study.

JMIR Med Inform 2020 May 29. Epub 2020 May 29.

Departments of Emergency Medicine, Biostatistics, and Health Informatics, Yale Schools of Medicine and Public Health, New Haven, US.

Background: Accurate identification of new diagnoses of human papillomavirus (HPV) associated cancers and precancers is an important step towards the development of strategies that optimize the use of HPV vaccines. The diagnosis of HPV cancers hinges on a histopathologic report, which is typically stored in the electronic medical records (EMR) as free-form, or unstructured narrative text. Previous efforts to perform surveillance for HPV cancers have relied on the manual review of pathology reports to extract diagnostic information, a process that is both labor- and resource-intensive. Read More

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http://dx.doi.org/10.2196/20826DOI Listing

HPV-associated oropharyngeal cancer: Knowledge and attitude/beliefs among non-clinical staff at community-based HIV/AIDS Service Organizations (ASO) in the south United States (U.S.) census region.

Health Soc Care Community 2020 May 28. Epub 2020 May 28.

College of Education and Human Development, Texas A&M University, College Station, TX, USA.

This study describes knowledge and attitude/beliefs about HPV-associated oropharyngeal cancer among non-clinical staff, at community-based HIV/AIDS Service Organizations (ASOs) located in the Southern U.S. states of South Carolina and Texas. Read More

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http://dx.doi.org/10.1111/hsc.13039DOI Listing

Candidate HPV genotypes not included in the 9-valent vaccine for prevention of CIN 2-3.

Int J Gynecol Cancer 2020 May 28. Epub 2020 May 28.

Obstetrics and Gynecology, Sant Joan de Deu Hospital, Barcelona, Catalunya, Spain.

Objectives: To identify the prevalence of human papillomavirus genotypes - as a single infection or co-infection - not included in the 9-valent (9v) HPV vaccine among women with cervical intraepithelial neoplasia (CIN 2-3).

Methods: Retrospective study of 1700 women referred due to abnormal cytology to Sant Joan de Deu Hospital. We selected 849 patients with CIN 2 or CIN 3 diagnosis confirmed by biopsy. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001069DOI Listing

Human Papillomavirus E6/E7 mRNA detection by in situ hybridization in oral cavity squamous cell carcinoma.

Arch Oral Biol 2020 May 7;116:104746. Epub 2020 May 7.

Programa de Pós-Graduação em Biotecnologia, Centro de Ciências da Saúde, Universidade Federal do Espirito Santo, Vitoria, Espirito Santo, Brazil. Electronic address:

Objective: The aim of this study was to evaluate the application of in situ hybridization using E6/E7 mRNA probes to identify the frequency of high-risk HPV transcriptionally active and the use of HPV status as a prognostic biomarker in oral cavity squamous cell carcinoma (OCSCC).

Methods: Ninety-nine OCSCC samples were evaluated from Hospital Santa Rita de Cassia, Hospital Universitário Cassiano Antônio de Moraes and University Hospitals Coventry and Warwickshire NHS Trust. After tissue microarray construction, the slides were submitted to an in situ hybridization detection method for HPV E6/E7 mRNA. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104746DOI Listing

Oral HPV prevalence assessment by Linear Array vs. SPF PCR-DEIA-LiPA system in the human papillomavirus Infection in Men (HIM) study.

Papillomavirus Res 2020 May 25:100199. Epub 2020 May 25.

Center for Immunization and Infection Research in Cancer (CIIRC), H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA. Electronic address:

Introduction: Oral human papillomavirus (HPV) attributable oropharyngeal cancers are on the rise in many countries. Oral HPV infections among healthy individuals are commonly detected using oral gargle samples. However, the optimal method for HPV genotyping oral gargle specimens in research studies has not been previously evaluated. Read More

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http://dx.doi.org/10.1016/j.pvr.2020.100199DOI Listing

Prevalence, incidence, and natural history of HPV infection in adult women ages 24 to 45 participating in a vaccine trial.

Papillomavirus Res 2020 May 25:100202. Epub 2020 May 25.

Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA. Electronic address:

Objectives: The natural history of human papillomavirus (HPV) infection has been studied extensively in young women; this study investigated HPV infection in adult women.

Methods: Data from 3817 women aged 24-45 years in a global trial of the 4-valent HPV (6/11/16/18) vaccine were used to calculate prevalence of anogenital infections containing 9-valent (9v) HPV vaccine types (6/11/16/18/31/33/45/52/58) and five non-vaccine types (35/39/51/56/59). Incidence of infections and persistent infections was estimated for 989 placebo recipients naive to all 14 HPV types at baseline. Read More

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http://dx.doi.org/10.1016/j.pvr.2020.100202DOI Listing

Viruses and esophageal cancer.

Dis Esophagus 2020 May 28. Epub 2020 May 28.

Case Western Reserve School of Medicine, Cleveland, OH, USA.

Esophageal adenocarcinoma (EAC) has had the fastest increasing incidence of any solid tumor in the United States in the last 30 years. Long standing gastroesophageal reflux disease is a well-established risk factor with strong associations with obesity, alcohol and tobacco. However, there are likely additional contributing factors. Read More

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http://dx.doi.org/10.1093/dote/doaa036DOI Listing

Emerging vaccine manufacturers are innovating for the next decade.

Vaccine X 2020 Aug 29;5:100066. Epub 2020 Apr 29.

DCVMN International, Route de Crassier 7, 1262 Nyon, Switzerland.

The Developing Countries Vaccine Manufacturers Network (DCVMN) is a public health-driven alliance consisting of 43 vaccine manufacturers from 14 countries and territories, operating under the mandate to protect all people against known and emerging infectious diseases, by improving the availability of high-quality vaccines globally. The Network provides a platform for organizations to come together regularly to share technical information, best practices and future prospects. DCVMN members are playing an increasingly important role in public health supplying over 50% of the doses of vaccines procured by UNICEF globally. Read More

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http://dx.doi.org/10.1016/j.jvacx.2020.100066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242873PMC

P16INK4A Immunohistochemistry as a Gold Standard for Cervical Cancer and Precursor Lesions Screening.

Iran J Public Health 2020 Feb;49(2):312-322

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: High-risk (HR) Human papillomaviruses (HPVs) are known as the main factors implicated in the pathogenesis of cervical preinvasive and invasive lesions. Therefore, the presence or absence of HR-HPV can be followed for the prognosis of low-grade and high-grade squamous intraepithelial lesions. Since the overexpression of p16INK4a protein depends on the presence of transcriptionally-active HPV, and due to its availability and simple interpretation, it may be considered as a proper marker to diagnose cervical cancer. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231710PMC
February 2020

Squamous cell anal cancer: Management and therapeutic options.

Ann Med Surg (Lond) 2020 Jul 12;55:36-46. Epub 2020 May 12.

Department of Surgery, Department of Applied Clinical Science and Biotechnology, University of L'Aquila, L'Aquila, Italy.

The incidence of anal cancer has increased during the second half of the 20th century, with an incidence rate over 2.9% greater than in the decade of 1992-2001. Yet, it still constitutes a small percentage, about 4%, of all anorectal tumours. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240186PMC

Invasive squamous cell carcinomas and precursor lesions on UV-exposed epithelia demonstrate concordant genomic complexity in driver genes.

Mod Pathol 2020 May 27. Epub 2020 May 27.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

Although squamous cell carcinomas (SCC) are the most frequent human solid tumor at many anatomic sites, the driving molecular alterations underlying their progression from precursor lesions are poorly understood, especially in the context of photodamage. Therefore, we used high-depth, targeted next-generation sequencing (NGS) of RNA and DNA from routine tissue samples to characterize the progression of both well- (cutaneous) and poorly (ocular) studied SCCs. We assessed 56 formalin-fixed paraffin-embedded (FFPE) cutaneous lesions (n = 8 actinic keratosis, n = 30 carcinoma in situ [CIS], n = 18 invasive) and 43 FFPE ocular surface lesions (n = 2 conjunctival/corneal intraepithelial neoplasia, n = 20 CIS, n = 21 invasive), from institutions in the US and Brazil. Read More

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http://dx.doi.org/10.1038/s41379-020-0571-7DOI Listing

The quadrivalent HPV vaccine is protective against genital warts: a meta-analysis.

BMC Public Health 2020 May 28;20(1):691. Epub 2020 May 28.

Department of Public Health, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, 6720, Hungary.

Background: The quadrivalent human papillomavirus (HPV) vaccine has been assumed to give protection against genital warts (GW) as well as cervical cancer. Our main question was whether HPV vaccine has any effects on the prevention of GW reported in randomised controlled clinical trials (RCTs) and time-trend analyses.

Methods: This meta-analysis was performed according to the PRISMA guidelines using the PICO format. Read More

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http://dx.doi.org/10.1186/s12889-020-08753-yDOI Listing

Molecular epidemiology and socio-demographic risk factors of sexually transmitted infections among women in Lebanon.

BMC Infect Dis 2020 May 27;20(1):375. Epub 2020 May 27.

Faculty of Health Sciences, University of Balamand, P.O.Box 166378 Ashrafieh, Beirut, 1100-2807, Lebanon.

Background: Sexually transmitted infections (STIs) cause a major public health problem that affect both men and women in developing and developed countries. The aim of the study was to estimate the prevalence of 11 STIs among women who voluntarily participated in the study, while seeking gynecological checkup. The existence of an association between the presence of pathogens and symptoms and various sociodemographic risk factors was assessed. Read More

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http://dx.doi.org/10.1186/s12879-020-05066-8DOI Listing

The current epidemic of HPV-associated oropharyngeal cancer: An 18-year Danish population-based study with 2,169 patients.

Eur J Cancer 2020 May 24;134:52-59. Epub 2020 May 24.

Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, 2100, Copenhagen East, Denmark. Electronic address:

Background: The objectives of this study were to investigate the incidence of high-risk genotypes of human papillomavirus (HPV) in tumours of patients with oropharyngeal squamous cell carcinoma (OPSCC) during an 18-year period in Eastern Denmark.

Methods: In this population-based, consecutive, semi-national registry study, all patients diagnosed with OPSCC from 2000 to 2017 in Eastern Denmark were evaluated at head and neck oncological departments at public university hospitals. Analyses included tumour characteristics (HPV-positive [HPV+] versus HPV-negative [HPV-]), age-adjusted incidence rates (AAIRs), average annual percentage change (AAPC) of OPSCC, and patient demographics. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.04.027DOI Listing

A Prospective Randomized Trial to Compare Safety, Acceptability and Efficacy of Thermal Ablation and Cryotherapy in a Screen and Treat Setting.

Asian Pac J Cancer Prev 2020 May 1;21(5):1391-1398. Epub 2020 May 1.

International Agency for Research on Cancer, Lyon, France.

Background: The prospective randomized study aimed to compare the safety, acceptability and efficacy of thermal ablation (TA) to that of cryotherapy in screen and treat setting.

Methods: The participants were recruited prospectively in a community-based screening clinic in India. Women positive on visual inspection with acetic acid (VIA) test and/or Human Papillomavirus (HPV) test were assessed for eligibility for ablative treatment. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1391DOI Listing

Structural dynamic studies on identification of EGCG analogues for the inhibition of Human Papillomavirus E7.

Sci Rep 2020 May 26;10(1):8661. Epub 2020 May 26.

Computer Aided Drug Design and Molecular Modeling Lab, Department of Bioinformatics, Alagappa University, Karaikudi, 630004, India.

High risk human papillomaviruses are highly associated with the cervical carcinoma and the other genital tumors. Development of cervical cancer passes through the multistep process initiated from benign cyst to increasingly severe premalignant dysplastic lesions in an epithelium. Replication of this virus occurs in the fatal differentiating epithelium and involves in the activation of cellular DNA replication proteins. Read More

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http://dx.doi.org/10.1038/s41598-020-65446-7DOI Listing

Mouthwash-Based Highly Sensitive Pyro-Genotyping for Nine Sexually Transmitted Human Papilloma Virus Genotypes.

Int J Mol Sci 2020 May 24;21(10). Epub 2020 May 24.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.

Human papillomavirus (HPV) is a common sexually transmitted infection worldwide, which spreads via contact with infected genital, anal, and oral/pharyngeal areas (oral sex) owing to diverse manners of sexual intercourse. In this study, we devised an oral HPV detection method using mouthwash waste fluids that causes less psychological resistance to visiting the outpatient otolaryngology departments. We successfully detected only the specific unique reverse sequencing probe (using pyro-genotyping) and identified the nine genotypes of HPV targeted for vaccination by pyrosequencing the mouthwash waste fluids of non-head and neck cancer patient volunteers ( = 52). Read More

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http://dx.doi.org/10.3390/ijms21103697DOI Listing

HPV Vaccination as Adjuvant to Conization in Women with Cervical Intraepithelial Neoplasia: A Study under Real-Life Conditions.

Vaccines (Basel) 2020 May 23;8(2). Epub 2020 May 23.

Department of Pathology, Hospital Clínic, University of Barcelona, 08036 Barcelona, Spain.

Recent studies have shown preliminary evidence that vaccination against human papillomavirus (HPV) could decrease the risk of persistent/recurrent HSIL in women treated for high-grade cervical intraepithelial lesion (HSIL). We aimed to determine the benefits of HPV vaccination in patients undergoing conization for HSIL in real-life conditions and evaluate vaccination compliance associated with different funding policies. From January 2013 to July 2018, 265 women underwent conization in our center. Read More

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http://dx.doi.org/10.3390/vaccines8020245DOI Listing

The Relationship between Estrogen-Related Signaling and Human Papillomavirus Positive Cancers.

Pathogens 2020 May 22;9(5). Epub 2020 May 22.

School of Dentistry, Philips Institute for Oral Health Research, Virginia Commonwealth University (VCU), Richmond, VA 23298, USA.

High risk-human papillomaviruses (HPVs) are known carcinogens. Numerous reports have linked the steroid hormone estrogen, and the expression of estrogen receptors (ERs), to HPV-related cancers, although the exact nature of the interactions remains to be fully elucidated. Here we will focus on estrogen signaling and describe both pro and potentially anti-cancer effects of this hormone in HPV-positive cancers. Read More

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http://dx.doi.org/10.3390/pathogens9050403DOI Listing

Impact of Smoking on Survival Outcomes in HPV-Related Oropharyngeal Carcinoma: A Meta-analysis.

Otolaryngol Head Neck Surg 2020 May 26:194599820931803. Epub 2020 May 26.

Department of Otorhinolaryngology-Head and Neck Surgery, Montefiore Medical Center, Bronx, New York, USA.

Objective: Characterize the survival impact of smoking on HPV-related (human papillomavirus) oropharyngeal squamous cell carcinoma.

Data Sources: Articles from 2000 to 2019 in the PubMed, Embase, and Cochrane Library databases were systematically reviewed for content and inclusion/exclusion criteria.

Review Methods: Two reviewers independently analyzed the databases for eligibility and quality of the articles. Read More

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http://dx.doi.org/10.1177/0194599820931803DOI Listing

Do Norms Matter? Examining Norm-Based Messages in HPV Vaccination Promotion.

Health Commun 2020 May 26:1-9. Epub 2020 May 26.

Edward R. Murrow College of Communication, Washington State University.

This research examines the influence of norm-based messages (positively worded descriptive vs. negatively worded descriptive vs. injunctive vs. Read More

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http://dx.doi.org/10.1080/10410236.2020.1770506DOI Listing

Cost-effectiveness analysis of a gender-neutral human papillomavirus vaccination program in the Netherlands.

Vaccine 2020 May 22. Epub 2020 May 22.

Department of Health Sciences, University of Groningen, University Medical Center, Hanzeplein 1, 9713 GZ Groningen, the Netherlands; Unit of Pharmacotherapy, Epidemiology & Economics, University of Groningen, Groningen Research Institute of Pharmacy, A Deusinglaan 1, 9713 AV Groningen, the Netherlands; Department of Economics, Econometrics & Finance, University of Groningen, Faculty of Economics & Business, P.O. Box 800, 9700 AV Groningen, the Netherlands. Electronic address:

Background: Vaccinating girls against human papillomavirus (HPV) infection is a highly effective and cost-effective intervention to provide protection against HPV-induced cancers. Since vaccination coverage rates among girls is modest in the Netherlands, additional strategies should be implemented to improve the protection against HPV-related cancer. Here we assessed the benefits and cost-effectiveness of gender-neutral vaccination. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.05.031DOI Listing

Periodontitis in tonsil cancer patients - a comparative study in accordance with tumour p16 status.

Oral Dis 2020 May 25. Epub 2020 May 25.

Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objectives: We assessed the periodontal situation radiologically according to tumour p16 status.

Materials And Methods: Patients with a diagnosis of tonsillar cancer and availability of a digital panoramic radiograph (DPR) during a 5-year period were included in this retrospective study. The predictor variables were periodontal stability, marginal bone loss, marginal bone loss without periodontal stability, and total number of teeth. Read More

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http://dx.doi.org/10.1111/odi.13437DOI Listing

Academic Affiliation and Surgical Volume Predict Survival in Head and Neck Cancer Patients Receiving Surgery.

Laryngoscope 2020 May 25. Epub 2020 May 25.

Department of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, U.S.A.

Objective: To determine whether the academic affiliation or surgical volume affects the overall survival (OS) of human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) patients receiving surgery.

Methods: A retrospective study of 39 North Carolina Medical Centers was conducted. Treatment centers were classified as academic hospitals, community cancer centers, or community hospitals and were divided into thirds by volume. Read More

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http://dx.doi.org/10.1002/lary.28744DOI Listing

Emotional response to testing positive for human papillomavirus at cervical cancer screening: a mixed method systematic review with meta-analysis.

Health Psychol Rev 2020 May 24:1-35. Epub 2020 May 24.

School of Cancer and Pharmaceutical Sciences, King's College London (KCL), London, UK.

Tens-of-millions of women every year test positive for human papillomavirus (HPV) at routine cervical screening. We performed a mixed-methods systematic review using a results-based convergent design to provide the first comprehensive overview of emotional response to testing positive for HPV (HPV+). We mapped our findings using the cognitive behavioural framework. Read More

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http://dx.doi.org/10.1080/17437199.2020.1762106DOI Listing

Is hysterectomy necessary for the treatment of preinvasive stratified mucin producing intraepithelial lesions of the cervix?

Int J Gynecol Cancer 2020 May 23. Epub 2020 May 23.

Department of Gynecologic Oncology, Weill Cornell Medicine, New York, New York, USA.

Objectives: Stratified mucin producing intraepithelial lesion (SMILE) is an uncommon premalignant cervical intraepithelial lesion, characterized by histopathologic features resembling those observed in high grade squamous intraepithelial lesions and adenocarcinoma in situ of the cervix. Its hybrid morphology poses a pathologic challenge with no specific management guidelines. The goal of this study was to review the natural history of SMILE and treatment based outcomes. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001272DOI Listing

Multicentric study of cervical cancer screening with human papillomavirus testing and assessment of triage methods in Latin America: the ESTAMPA screening study protocol.

BMJ Open 2020 May 24;10(5):e035796. Epub 2020 May 24.

Prevention and Implementation Group, International Agency for Research on Cancer, Lyon, Rhône-Alpes, France.

Introduction: Human papillomavirus (HPV) testing is replacing cytology in primary screening. Its limited specificity demands using a second (triage) test to better identify women at high-risk of cervical disease. Cytology represents the immediate triage but its low sensitivity might hamper HPV testing sensitivity, particularly in low-income and middle-income countries (LMICs), where cytology performance has been suboptimal. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035796DOI Listing

Ultrasonographic Imaging Features of Female Urethral and Peri-urethral Masses: A Retrospective Study of 95 Patients.

Ultrasound Med Biol 2020 May 21. Epub 2020 May 21.

Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, Republic of China. Electronic address:

The aim of this study was to assess the imaging features of urethral and peri-urethral masses on transvaginal or transperineal ultrasound (US) in a cohort of 95 women. In this retrospective study, medical records of 95 female patients with 98 asymptomatic or symptomatic urethral and peri-urethral masses were retrospectively reviewed. Data regarding patient demographic characteristics, symptoms, signs, imaging features on 2-D and 3-D transvaginal or transperineal US, diagnostic tests and physical and intra-operative findings were extracted. Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2020.03.024DOI Listing

Fifteen new nucleotide substitutions in variants of human papillomavirus 18 in Korea : Korean HPV18 variants and clinical manifestation.

Virol J 2020 May 24;17(1):70. Epub 2020 May 24.

Department of Laboratory Medicine, Seoul National University Metropolitan Government Boramae Medical Center, Seoul, South Korea.

High-risk human papillomavirus (HPV) infection is an essential factor for the development of cervical cancer. HPV18 is the second most common carcinogenic HPV type following HPV16, but the lineages of HPV18 have been less well studied than those of HPV 16. The purpose of this study was to analyze the nucleotide variants in the E6, E7, and L1 genes of HPV18, to assess the prevalence of HPV18 variants in Korea and to explore the relationship between HPV18 genetic variants and the risk for cervical cancer. Read More

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http://dx.doi.org/10.1186/s12985-020-01337-7DOI Listing

Vaccine Hesitancy as a Challenge or Vaccine Confidence as an Opportunity for Childhood Immunisation in India.

Infect Dis Ther 2020 May 23. Epub 2020 May 23.

Private Practitioner, 4-Kabir Marg, Lucknow, India.

Vaccines have contributed substantially to decreasing the morbidity and mortality rates of many infectious diseases worldwide. Despite this achievement, an increasing number of parents have adopted hesitant behaviours towards vaccines, delaying or even refusing their administration to children. This has implications not only on individuals but also society in the form of outbreaks for e. Read More

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http://dx.doi.org/10.1007/s40121-020-00302-9DOI Listing

IL-10 c.-592C>A (rs1800872) polymorphism is associated with cervical cancer.

J Cancer Res Clin Oncol 2020 May 23. Epub 2020 May 23.

Department of General Pathology, Biological Sciences Center, State University of Londrina, 86057-970, Londrina, PR, Brazil.

Purpose: Interleukin-10 (IL-10) is an immunoregulatory cytokine and its cervical and serum concentrations have been associated with a poor prognosis of cervical cancer. The rs1800872 polymorphism (c.-592C>A) in the promotor region of the IL-10 gene affects the production and expression of IL-10 and thus is able to determine the immune response profile in the cervix. Read More

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http://dx.doi.org/10.1007/s00432-020-03256-0DOI Listing