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    Relationship between the risk factors for human papillomavirus infection and lower genital tract precursor lesion and cancer development in female transplant recipients.
    Transpl Infect Dis 2017 Apr 29. Epub 2017 Apr 29.
    Statistics Department, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.
    Background: This study aimed to analyze the relationship between the several risk factors for human papillomavirus (HPV) infection and its persistence and to assess the prevalence of the lower genital tract precursor lesions, cancer, and HPV infection in female transplant recipients, besides the most prevalent HPV types.

    Methods: The methodology adopted was a cross-sectional study with a random sample of 61 patients.

    Results: The results indicated 10 cases (16. Read More

    Two-dose schedules for human papillomavirus vaccine: Systematic review and meta-analysis.
    Vaccine 2017 Apr 25. Epub 2017 Apr 25.
    Institute of Social and Preventive Medicine (ISPM), University of Bern, Finkenhubelweg 11, 3012 Bern, Switzerland. Electronic address:
    Simpler schedules for human papillomavirus (HPV) vaccine delivery could improve vaccine coverage and the effectiveness of cervical cancer prevention. The objective of this study was to systematically review evidence about the effects of two-dose compared with three-dose schedules for human papillomavirus (HPV) vaccine and to describe the uptake of two-dose HPV vaccination schedules globally. We searched PubMed, the Cochrane Central Registry of Controlled Trials, trials registers, and manufacturers' databases from their earliest date to February 2016. Read More

    Pediatrician-Parent Conversations About Human Papillomavirus Vaccination: An Analysis of Audio Recordings.
    J Adolesc Health 2017 Apr 18. Epub 2017 Apr 18.
    Department of Pediatrics, Section of Adolescent Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
    Purpose: We sought to establish which human papillomavirus (HPV) vaccine communication approaches by pediatricians were associated with same-day HPV vaccination of 11- to 12-year-olds by evaluating audio recordings of visits.

    Methods: Verilogue, a market research company maintaining a panel of primary care pediatricians, provided audio recordings and transcriptions of well-child visits for 11- to 12-year-old patients from January through June 2013. Seventy-five transcripts from 19 pediatricians were coded for use of presumptive language (i. Read More

    Prevalence of human papillomavirus infection of the anal canal in women: A prospective analysis of high-risk populations.
    Oncol Lett 2017 Apr 10;13(4):2495-2501. Epub 2017 Feb 10.
    Department of Gynecology and Obstetrics, Ludwig-Maximilian University of Munich, D-80337 Munich, Germany.
    Infection with certain types of human papillomavirus (HPV) has been associated with the development of cervical and anal cancer. Worldwide, the incidence of anal cancer has increased markedly. The present study aimed to evaluate the prevalence of HPV infection of the uterine cervix and anal canal in human immunodeficiency virus (HIV)- and non-HIV-infected risk populations. Read More

    Notch is a critical regulator in cervical cancer by regulating Numb splicing.
    Oncol Lett 2017 Apr 7;13(4):2465-2470. Epub 2017 Feb 7.
    Department of Gynaecology and Obstetrics, The Affiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu 214000, P.R. China.
    Cervical cancer, which is the second most common female malignancy, is characterized by the consistent presence of human papillomavirus. Inappropriate activation of Notch signaling has been associated with various types of cancer; however, the role of Notch in cervical cancer remains unclear. The present study aimed to investigate the role of Notch in cervical cancer. Read More

    Characterization of topoisomerase II α and minichromosome maintenance protein 2 expression in anal carcinoma.
    Oncol Lett 2017 Mar 25;13(3):1891-1898. Epub 2017 Jan 25.
    Molecular Oncology Research Center, Barretos Cancer Hospital, Pio XII Foundation, Barretos, São Paulo, SP 14784-400, Brazil.
    The present study aimed to ascertain the significance of topoisomerase II α (TOP2A) and minichromosome maintenance protein (MCM) 2 expression in anal carcinoma. A total of 75 anal lesions were retrieved from the files of the Department of Pathology of Barretos Cancer Hospital (Barretos, Brazil) in order to verify the human papillomavirus (HPV) statuses of these lesions and characterize the immunohistochemical expression levels of TOP2A and MCM2 in anal carcinoma, as these are important markers for cervical HPV-induced lesions; their expression was also compared with respect to p16 and Ki-67. The vast majority of the cases tested positive for HPV16 (84%); 1 case tested positive for both HPV16 and HPV18. Read More

    DNA vaccine encoding human papillomavirus antigens flanked by a signal peptide and a KDEL sequence induces a potent therapeutic antitumor effect.
    Oncol Lett 2017 Mar 23;13(3):1569-1574. Epub 2017 Jan 23.
    Department of Histology, Faculty of Medicine, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon 64460, México.
    Cellular immune responses play a critical role in the eradication of intracellular infections and malignant cells through the recognition and subsequent removal of the infection or malignant cells. Effective antigen presentation is crucial for stimulating the immune system against malignant cells. Calreticulin (CRT) has been used to improve antigen presentation. Read More

    High-risk human papillomavirus in anal squamous cell carcinoma: a 'conservative' leading role.
    Ann Oncol 2017 May;28(5):1160
    Unit of Gastrointestinal and Neuroendocrine Tumors; 2Division of Pathology; 3Unit of Viral Control of Cellular Pathways and Biology of Tumorigenesis; 4Divisions of Radiotherapy; 5Endoscopy; 6General Surgery; 7Hepatobiliary and Pancreatic Surgery, European Institute of Oncology (IEO), Milan, Italy.

    The synergic effect of HPV infection and epigenetic anomaly of the p16 gene in the development of cervical cancer.
    Cancer Biomark 2017 Apr 14. Epub 2017 Apr 14.
    Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India.
    Background: Cervical cancer is the most common cancer in Indian women. Infection with a high-risk human papillomavirus (HR-HPV) is the greatest risk factor for developing cervical cancer. The genetic and epigenetic changes in the tumor suppressor p16 gene is play an important role in the development of cervical cancer. Read More

    Prevalence of human papillomavirus, Chlamydia trachomatis, and Trichomonas vaginalis infections in Amazonian women with normal and abnormal cytology.
    Genet Mol Res 2017 Apr 28;16(2). Epub 2017 Apr 28.
    Laboratório de Diagnóstico Molecular, Centro de Apoio Multidisciplinar, , , Brasil.
    Sexually transmitted infections are an important cause of morbidity among sexually active women worldwide, and have been implicated as cofactors in the pathogenesis of cervical cancer. We investigated the prevalence of human papillomavirus (HPV), Chlamydia trachomatis (CT), and Trichomonas vaginalis (TV), and accessed the diversity of HPV in women with normal and abnormal cytology in Manaus, Brazil. We used polymerase chain reaction and HPV genotyping by direct sequencing. Read More

    Predictors for recurrent/persistent high-grade intraepithelial lesions and cervical stenosis after therapeutic conization: a retrospective analysis of 522 cases.
    Int J Clin Oncol 2017 Apr 27. Epub 2017 Apr 27.
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
    Objective: The objective of the study is to identify the risk factors associated with recurrent/persistent disease and cervical stenosis after conization.

    Methods: Five hundred twenty-two (522) cases of high-grade intraepithelial lesions treated by conization were retrospectively reviewed. Risk factors associated with recurrent/persistent disease were analyzed by univariate and multivariate analysis using a Cox hazard regression model. Read More

    Solid Lymph Nodes as an Imaging Biomarker for Risk Stratification in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma.
    AJNR Am J Neuroradiol 2017 Apr 27. Epub 2017 Apr 27.
    From the Departments of Radiology (T.J.R., M.A.H., B.F.B.), Otolaryngology (T.J.R., M.A.H., R.L.F., B.F.B.), and Pathology (S.I.C.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and Department of Radiology (S.N.), Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
    Background And Purpose: Human papillomavirus-related oropharyngeal squamous cell carcinoma is associated with cystic lymph nodes on CT and has a favorable prognosis. A subset of patients with aggressive disease experience treatment failure. Our aim was to determine whether the extent of cystic lymph node burden on staging CT can serve as an imaging biomarker to predict treatment failure in human papillomavirus-related oropharyngeal squamous cell carcinoma. Read More

    Perturbation of DROSHA and DICER expression by human papillomavirus 16 oncoproteins.
    Virology 2017 Apr 24;507:192-198. Epub 2017 Apr 24.
    Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA. Electronic address:
    Many tumors, including cervical carcinoma, show dysregulated expression of the microRNA processing machinery, specifically DROSHA and DICER. Some cervical cancers exhibit chromosome 5p amplifications and DROSHA is the most significantly upregulated transcript and is observed in all tumors with 5p gain. DROSHA and DICER mRNA levels, however, are higher in HPV positive cancer lines than in an HPV negative cervical carcinoma line. Read More

    Regulation of the human papillomavirus type 16 late promoter by transcriptional elongation.
    Virology 2017 Apr 24;507:179-191. Epub 2017 Apr 24.
    Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, and Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA, USA. Electronic address:
    Transcripts from the late promoter of human papillomavirus type 16 (HPV16) are upregulated upon host cell differentiation. Differentiation-dependent transcript regulation is thought to sequester viral antigens in the uppermost epithelial layers, facilitating immune evasion. The mechanisms regulating late promoter upregulation during differentiation are poorly characterized. Read More

    Human papillomavirus 9-valent vaccine for cancer prevention: a systematic review of the available evidence.
    Epidemiol Infect 2017 Apr 27:1-21. Epub 2017 Apr 27.
    Giovanni Lorenzini Medical Science Foundation,Houston, TX,USA.
    In 2014, the Food and Drug Administration approved a new human papillomavirus 9-valent vaccine (9vHPV), targeting nine HPV types: HPV types 6, 11, 16, and 18, which are also targeted by the quadrivalent HPV vaccine (qHPV), plus five additional high cancer risk HPV types (HPV types 31, 33, 45, 52, and 58). The aim of the current study was to systematically retrieve, qualitatively and quantitatively pool, as well as critically appraise all available evidence on 9vHPV from randomized controlled trials (RCTs). We conducted a systematic review of the literature on 9vHPV efficacy, immunogenicity and safety, as well as a systematic search of registered, completed, and ongoing RCTs. Read More

    Pooled analysis on the necessity of random 4-quadrant cervical biopsies and endocervical curettage in women with positive screening but negative colposcopy.
    Medicine (Baltimore) 2017 Apr;96(17):e6689
    aDepartment of Cancer Epidemiology bDepartment of Gynecological Oncology cDepartment of Cytology dDepartment of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Controversy remains over whether random cervical biopsies and endocervical curettage (ECC) should be used in women with positive screening but negative colposcopy. Our paper aims to determine the indications for random biopsies and ECC among these screened positive women.Three thousand two hundred thirteen women with any positive screening test result but negative colposcopy, who received random 4-quadrant biopsies, were pooled from 17 population-based cervical cancer screening studies done in China from 1999 to 2008. Read More

    Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection.
    Tumour Biol 2017 Apr;39(4):1010428317697547
    1 Key Laboratory of Chinese Ministry of Education and Xinjiang Uighur Autonomous Region for High-Incident Diseases in Uighur Ethnic Population, Xinjiang Medical University, Urumqi, P.R. China.
    It is known that high-risk human papillomavirus infection is the main etiological factor in cervical carcinogenesis. However, human papillomavirus screening is not sufficient for early diagnosis. In this study, we aimed to identify potential biomarkers common to cervical carcinoma and human papillomavirus infection by proteomics for human papillomavirus-based early diagnosis and prognosis. Read More

    Codon Usage Optimization and Construction of Plasmid Encoding Iranian Human Papillomavirus Type 16 E7 Oncogene for Lactococcus Lactis Subsp. Cremoris MG1363
    Asian Pac J Cancer Prev 2017 03 1;18(3):783-788. Epub 2017 Mar 1.
    Department of Microbiology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, IR Iran. Email:
    HPV 16 intratypic sequence variations has been recognized in association with oncogenic potential diverge and geographic distribution. This study aimed to investigate nucleotide modifications and optimization of HPV 16 E7 regions from Iranian infected women. Cervical biopsies from 79/163 HPV 16 positive cancer patients detected in our study were analyzed by PCR in a couple of cloning of a complete ORF of the E7 gene, and sequencing. Read More

    Hepatocyte Growth Factor/c-Met Signaling in Head and Neck Cancer and Implications for Treatment.
    Cancers (Basel) 2017 Apr 24;9(4). Epub 2017 Apr 24.
    Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
    Aberrant signaling of the hepatocyte growth factor (HGF)/c-Met pathway has been identified as a promoter of tumorigenesis in several tumor types including head and neck squamous cell carcinoma (HNSCC). Despite a relatively low c-Met mutation frequency, overexpression of HGF and its receptor c-Met has been observed in more than 80% of HNSCC tumors, with preclinical and clinical studies linking overexpression with cellular proliferation, invasion, migration, and poor prognosis. c-Met is activated by HGF through a paracrine mechanism to promote cellular morphogenesis enabling cells to acquire mesenchymal phenotypes in part through the epithelial-mesenchymal transition, contributing to metastasis. Read More

    Long-term nitrite inhalant exposure and cancer risk in MSM.
    AIDS 2017 May;31(8):1169-1180
    aDepartment of Cancer Immunology and Virology bCenter for Population Science, Dana-Farber Cancer Institute, Boston, Massachusetts cDivision of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
    Objectives: Nitrite inhalants (poppers) are commonly used recreational drugs among MSM and were previously associated with elevated rates of high-risk sexual behavior, HIV and human herpesvirus type 8 (HHV-8) seroconversion, and transient immunosuppressive effects in experimental models. Whether long-term popper use is associated with cancer risk among MSM in the HAART era is unclear.

    Design: Prospective cohort study of cancer risk in 3223 HIV-infected and uninfected MSM in the Multicenter AIDS Cohort Study from 1996-2010. Read More

    Methylation Status of P16Ink4a in Human Papillomavirus-Associated Cancer of Oral Cavity and Oropharynx in Northeastern Thailand
    Asian Pac J Cancer Prev 2017 03 1;18(3):699-705. Epub 2017 Mar 1.
    Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. Email:
    Background: Over-expression of p16INK4a protein is a biomarker for human papillomavirus (HPV)-associated cervical cancer. However, absence of p16INK4a protein expression in HPV-associated cancer of the oral cavity and oropharynx has been reported. Among a number of possible reasons for this is methylation, which is frequently noted in the promoter region of p16INK4a and is associated with silencing of the gene and disease severity. Read More

    Diagnostic Value of the CareTM HPV Test in Screening for Cervical Intraepithelial Neoplasia Grade 2 or Worse
    Asian Pac J Cancer Prev 2017 03 1;18(3):687-693. Epub 2017 Mar 1.
    Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Sadooghi University of Medical Science, Yazd. Email:
    Background: Cervical cancer is the fourth leading cause of cancer death in women worldwide. Persistent infection with a high risk human papillomavirus (HR-HPV) is the main etiological factor, so that early early detection of HR-HPV is very important. The aim of this study was to investigate the efficacy of CareTM HPV, a new method, as compared with Pap smear, PCR, and biopsy for screening purposes. Read More

    Roles of the PDZ-binding motif of HPV 16 E6 protein in oncogenic transformation of human cervical keratinocytes.
    Cancer Sci 2017 Apr 25. Epub 2017 Apr 25.
    Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045.
    The high-risk human papillomavirus E6 proteins have been shown to interact with and lead degradation of PDZ-domain-containing proteins through its carboxy-terminal motif. This PDZ-binding motif plays important roles in transformation of cultured cells and carcinogenesis of E6-transgenic mice. However, its biological effects on the natural host cells have not been elucidated. Read More

    Cervical cancer in sub-Saharan Africa: a preventable noncommunicable disease.
    Expert Rev Anti Infect Ther 2017 Apr 25. Epub 2017 Apr 25.
    a Laboratoire de virologie, hôpital Européen Georges Pompidou , Assistance Publique-Hôpitaux de Paris.
    Introduction: Infections caused by high-risk human papillomavirus (HPV) are responsible for 7.7% of cancers in developing countries, mainly cervical cancer. This disease is steadily increasing in sub-Saharan Africa, with more than 75,000 new cases and 50,000 deaths yearly, further increased by HIV infection. Read More

    The presence and prognostic significance of human papillomavirus in squamous cell carcinoma of the larynx.
    Eur Arch Otorhinolaryngol 2017 Apr 21. Epub 2017 Apr 21.
    Department of Pathology, University of Health Sciences, Sultan Abdulhamid Han Training Hospital, Istanbul, Turkey.
    The aim of the present study was to evaluate the role of HPV in laryngeal squamous cell carcinoma and correlate it with patients' clinicopathological data. In total, 78 laryngeal squamous cell carcinoma patients enrolled in this study. The presence of genotype-specific HPV DNA was evaluated using Genotyping Assay in formalin-fixed paraffin-embedded tissue which was diagnosed between 2005 and 2015. Read More

    Association between stage at diagnosis and knowledge on cervical cancer among patients in a Kenyan tertiary hospital: a cross-sectional study.
    Pan Afr Med J 2016 26;25(Suppl 2):15. Epub 2016 Nov 26.
    AMREF Health Africa, Kenya.
    Introduction: In Kenya, cervical cancer is the second most common cancer among women; almost half of all women with invasive cervical cancer are diagnosed at a late stage. Few women are aware of the symptoms and risk factors of cervical cancer and that its precursor lesions are detectable through screening thus most women seek treatment when the cancer is at an advanced stage. The study explored the influence of cervical cancer awareness on stage at diagnosis in patients attending Kenyatta National Hospital. Read More

    Can gene editing and silencing technologies play a role in the treatment of head and neck cancer?
    Oral Oncol 2017 May 10;68:9-19. Epub 2017 Mar 10.
    School of Medical Science, Griffith University, Gold Coast Campus, Southport 4222, Queensland, Australia; Understanding Chronic Conditions Program, Menzies Health Institute Queensland, Australia. Electronic address:
    Conventional treatment strategies have done little to improve the prognosis or disease-free survival in head and neck cancer (HNC) patients. Recent progress in our understanding of molecular aspects of head and neck squamous cell carcinoma (HNSCC) has provided insights into the potential use of molecular targeted therapies in combination with current treatment strategies. Here we review the current understanding of treatment modalities for both HPV-positive and HPV-negative HNSCCs with the potential to use gene editing and silencing technologies therapeutically. Read More

    Discussing HPV with oropharyngeal cancer patients: A cross-sectional survey of attitudes in health professionals.
    Oral Oncol 2017 May 1;68:67-73. Epub 2017 Apr 1.
    Cancer Communication & Screening Group, Research Department of Behavioural Science and Health, UCL, Gower Street, WC1E6BT, United Kingdom.
    Background: Human papillomavirus (HPV) is now known to cause a significant proportion of head and neck cancers (HNC). Qualitative research has shown that some health professionals find it difficult to discuss HPV with patients due to its sexually transmitted nature, and have concerns about their own knowledge of the virus. We used a survey to quantify attitudes towards discussing HPV among HNC health professionals. Read More

    A model using concomitant markers for predicting outcome in human papillomavirus positive oropharyngeal cancer.
    Oral Oncol 2017 May 23;68:53-59. Epub 2017 Mar 23.
    Dept. of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden. Electronic address:
    Objective: Head-neck cancer therapy has become intensified. With radiotherapy alone, 3-year disease-free survival (DFS) is 80% for HPV-positive TSCC/BOTSCC and better for patients with favorable characteristics, suggesting therapy could be tapered for some, decreasing side-effects. Therefore, we built a model to predict progression-free survival for patients with HPV-positive TSCC and BOTSCC. Read More

    Primary, secondary and tertiary prevention of human papillomavirus-driven head and neck cancers.
    Eur J Cancer 2017 Apr 19;78:105-115. Epub 2017 Apr 19.
    Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
    Human papillomavirus (HPV)-driven oropharyngeal cancers (OPCs) represent an increasing proportion of head and neck cancers that could become, in the next few decades, a public health problem in certain western countries. This significant epidemiological change strongly calls for preventive measures. Prophylactic HPV vaccination and screening programmes for early identification and treatment of premalignant lesions are currently being used to reduce the incidence of uterine cervical cancer, which is the paradigm of HPV-driven malignancy. Read More

    Primary HPV testing verification: A retrospective ad-hoc analysis of screening algorithms on women doubly tested for cytology and HPV.
    Diagn Cytopathol 2017 Apr 23. Epub 2017 Apr 23.
    Department of Pathology, the University of Alabama at Birmingham School of Medicine, Birmingham, Alabama.
    Background: To evaluate human papillomavirus (HPV) testing as a primary screening tool, we retrospectively analyzed data comparing (1) HPV testing to the algorithms of the ATHENA Study: (2) cytology alone, (3) cytology with ASCUS triage in women 25-29 and (4) cotesting ≥ 30 or (5) cotesting ≥ 25.

    Methods: We retrospectively analyzed data from women tested with both cytology and HPV testing from 2010 to 2013. Cumulative risk (CR) for CIN3+ was calculated. Read More

    The vaginal microbiome and gynaecological cancer: exercise caution when considering causation.
    BJOG 2017 Apr 24. Epub 2017 Apr 24.
    Department of Obstetrics and Gynaecology, St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
    Genital infection with high-risk human papillomavirus (HPV) is extremely common in young, sexually active women, but most infections are transient and clear without ever causing disease. Persistent infection causes premalignant cervical intraepithelial neoplasia (CIN), which, if left untreated, can undergo malignant transformation and become invasive cancer. Cervical cancer is thus considered a late, rare consequence of persistent high-risk HPV infection (Crosbie et al. Read More

    The changing landscape of cervical screening-What does the future hold for primary care?
    Eur J Cancer Care (Engl) 2017 Apr 23. Epub 2017 Apr 23.
    Department of Behavioural Science and Health, Institute of Epidemiology & Health Care, UCL, London, UK.
    The landscape of cervical cancer prevention is changing in many countries thanks to the introduction of vaccination against high-risk types of human papillomavirus (HPV) and the incorporation of HPV DNA testing into cervical screening algorithms. In addition to this, uptake of screening is falling year on year in the UK and elsewhere. These factors present challenges and opportunities for health professionals working in primary care-in terms of communicating programmatic changes to women; responding to questions about the meaning and implications of HPV test results; and delivering interventions to increase screening uptake. Read More

    Impact of a brief intervention on cervical health literacy: A waitlist control study with jailed women.
    Prev Med Rep 2017 Jun 5;6:314-321. Epub 2017 Apr 5.
    School of Nursing, University of Missouri Kansas City, Kansas City, MO, United States.
    Jailed women are four-five times more likely to have had cervical cancer compared to women without criminal justice histories. Previous research has shown that an important contributor to cervical cancer risk, and perhaps lack of follow-up, is incarcerated women's low health literacy about broader reproductive health issues. Little work has been done to address this disparity. Read More

    A Multiple Streams analysis of the decisions to fund gender-neutral HPV vaccination in Canada.
    Prev Med 2017 Apr 20;100:123-131. Epub 2017 Apr 20.
    Department of Psychology, McGill University, 1205 Dr. Penfield Avenue, Montreal H3A 1B1, Quebec, Canada; Lady Davis Institute for Medical Research, Jewish General Hospital, 4333 Côte St-Catherine Road, Montreal H3T 1E4, Quebec, Canada; Louise Granofsky Psychosocial Oncology Program, Jewish General Hospital, 4333 Côte St-Catherine Road, Montreal H3T 1E4, Quebec, Canada; Departments of Psychiatry and Oncology, McGill University, 1205 Dr. Penfield Avenue, Montreal H3A 1B1, Quebec, Canada.
    In Canada, the human papillomavirus (HPV) vaccine is licensed and recommended for females and males. Although all Canadian jurisdictions fund school-based HPV vaccine programs for girls, only six jurisdictions fund school-based HPV vaccination for boys. The research aimed to analyze the factors that underpin government decisions to fund HPV vaccine for boys using a theoretical policy model, Kingdon's Multiple Streams framework. Read More

    Reduced-dose radiotherapy for human papillomavirus-associated squamous-cell carcinoma of the oropharynx: a single-arm, phase 2 study.
    Lancet Oncol 2017 Apr 20. Epub 2017 Apr 20.
    Department of Radiation Oncology, University of California, Davis, School of Medicine, Sacramento, CA, USA.
    Background: Head and neck cancers positive for human papillomavirus (HPV) are exquisitely radiosensitive. We investigated whether chemoradiotherapy with reduced-dose radiation would maintain survival outcomes while improving tolerability for patients with HPV-positive oropharyngeal carcinoma.

    Methods: We did a single-arm, phase 2 trial at two academic hospitals in the USA, enrolling patients with newly diagnosed, biopsy-proven stage III or IV squamous-cell carcinoma of the oropharynx, positive for HPV by p16 testing, and with Zubrod performance status scores of 0 or 1. Read More

    Description of a novel multiplex avidity assay for evaluating HPV antibodies.
    J Immunol Methods 2017 Apr 19. Epub 2017 Apr 19.
    Chronic Viral Diseases Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, USA. Electronic address:
    Limited data exists regarding antibody avidity for human papillomavirus (HPV). We describe development of a multiplex electrochemiluminescent avidity ELISA for four HPV types (HPV 6, 11, 16, 18) by adding a dissociating step to our established multiplex HPV VLP ELISA. Initial experiments exploring ammonium thiocyanate, sodium thiocyanate and guanidine hydrochloride (GuHCl) as dissociating agents identified GuHCl as most promising. Read More

    Unique LCR variations among lineages of HPV16, 18 and 45 isolates from women with normal cervical cytology in Ghana.
    Virol J 2017 Apr 21;14(1):85. Epub 2017 Apr 21.
    National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
    Background: In addition to being useful for classification, sequence variations of human Papillomavirus (HPV) genotypes have been implicated in differential oncogenic potential and a differential association with the different histological forms of invasive cervical cancer. These associations have also been indicated for HPV genotype lineages and sub-lineages. In order to better understand the potential implications of lineage variation in the occurrence of cervical cancers in Ghana, we studied the lineages of the three most prevalent HPV genotypes among women with normal cytology as baseline to further studies. Read More

    Epidemiology and genotype distribution of human papillomavirus (HPV) in Southwest China: a cross-sectional five years study in non-vaccinated women.
    Virol J 2017 Apr 21;14(1):84. Epub 2017 Apr 21.
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, 400016, Chongqing, People's Republic of China.
    Background: Large-size data on type-specific HPV prevalence in Southwest China are required to estimate the cervical cancer burden in the country and to prepare for HPV-based cervical screening program and further HPV vaccination of China. This HPV study is a pooled analysis of data from five years in Chongqing of China, which is cross-sectional in design using data collecting.

    Results: The positivity of HPV was 26. Read More

    Quality of life in survivors of oropharyngeal cancer: A systematic review and meta-analysis of 1366 patients.
    Eur J Cancer 2017 Apr 18;78:91-102. Epub 2017 Apr 18.
    Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark. Electronic address:
    Human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) is rapidly increasing in incidence and has a favourable prognosis compared with HPV-negative disease. Current combined therapies include significant risks of morbidity for the growing group of survivors. This systematic review and meta-analysis investigates how treatment affects quality of life (QoL) in survivors of oropharyngeal cancer. Read More

    Cervicovaginal Levels of Human β-Defensin 1, 2, 3, and 4 of Reproductive-Aged Women With Chlamydia trachomatis Infection.
    J Low Genit Tract Dis 2017 Apr 21. Epub 2017 Apr 21.
    1Department of Pathology, Botucatu Medical School, UNESP, Universidade Estadual Paulista, São Paulo, Brazil; 2Department of Basic Pathology, Setor de Ciências Biológicas, UFPR, Universidade Federal do Paraná, Curitiba, Brazil; and 3The University of Western São Paulo (UNOESTE), Presidente Prudente, São Paulo, Brazil.
    Objective: This study included women attending primary health care units in Botucatu, São Paulo, Brazil, to assess the cervicovaginal levels of human β-defensin (hBD) 1, 2, 3, and 4 during Chlamydia trachomatis infection.

    Patients And Methods: Cervicovaginal samples were collected for Pap testing and assessing the presence of infection by C. trachomatis, human papillomavirus, Neisseria gonorrhoeae, and Trichomonas vaginalis. Read More

    TAK1 inhibitor 5Z-7-oxozeaenol sensitizes cervical cancer to doxorubicin-induced apoptosis.
    Oncotarget 2017 Apr 6. Epub 2017 Apr 6.
    Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, Xinjiang 830046, China.
    Aberrant activation of nuclear factor-κB (NF-κB) allows cancer cells to escape chemotherapy-induced cell death and acts as one of the major mechanisms of acquired chemoresistance in cervical cancer. TAK1, a crucial mediator that upregulates NF-κB activation in response to cellular genotoxic stress, is required for tumor cell viability and survival. Herein, we examined whether TAK1 inhibition is a potential therapeutic strategy for treating cervical cancer. Read More

    [HPV vaccination: active offer in an Italian region].
    Ig Sanita Pubbl 2017 Jan-Feb;73(1):77-94
    Dipartimento di Biomedicina e Prevenzione, Università degli Studi di Roma Tor Vergata, Roma, Italia.
    Human Papillomavirus is responsible for 4.8% of cancers, and is the main cause of cervical cancer. Cervical cancer can be reduced by mean of secondary prevention (PAP-test, HPV-DNA test), while through primary prevention (anti-HPV vaccine) the incidence of other HPV-attributable cancers can also be reduced. Read More

    Texting and Mobile Phone App Interventions for Improving Adherence to Preventive Behavior in Adolescents: A Systematic Review.
    JMIR Mhealth Uhealth 2017 Apr 19;5(4):e50. Epub 2017 Apr 19.
    Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Division of Adolescent Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
    Background: Many preventable behaviors contribute to adolescent mortality and morbidity. Non-adherence to preventive measures represents a challenge and has been associated with worse health outcomes in this population. The widespread use of electronic communication technologies by adolescents, particularly the use of text messaging (short message service, SMS) and mobile phones, presents new opportunities to intervene on risk and preventive risk behavior, but little is known about their efficacy. Read More

    Recurrent respiratory papillomatosis: A state-of-the-art review.
    Respir Med 2017 May 1;126:116-121. Epub 2017 Apr 1.
    Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:
    Recurrent respiratory papillomatosis (RRP) is a benign disease of the upper aero-digestive tract caused by human papillomavirus (HPV) infection, which affects children and young adults. The aim of this review is to describe the main etiological, epidemiological, clinical, diagnostic, and treatment aspects of RRP. Most infections in children occur at birth, during passage through the birth canals of contaminated mothers. Read More

    Human papillomavirus infection as a prognostic marker for lung adenocarcinoma: a systematic review and meta-analysis.
    Oncotarget 2017 Feb 24. Epub 2017 Feb 24.
    Department of Cancer Epidemiology, Henan Office for Cancer Control and Research, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.
    Although a number of studies have investigated the association between human papillomavirus (HPV) and lung cancer prognosis, the results remain inconsistent. We therefore conducted a meta-analysis of epidemiologic studies to address this issue. Searches of the MEDLINE and EMBASE electronic databases from their inception until June 30, 2016 yielded nine studies involving a total of 1,205 lung cancer cases that were used to conduct the meta-analysis. Read More

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