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    Outcomes in Women With Cytology Showing Atypical Squamous Cells of Undetermined Significance With vs Without Human Papillomavirus Testing.
    JAMA Oncol 2017 Jun 22. Epub 2017 Jun 22.
    Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque6Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque.
    Importance: Little is known about the long-term yield of high-grade cervical intraepithelial neoplasia (CIN) and the influence on biopsy and treatment rates of human papillomavirus (HPV) triage of cytology showing atypical squamous cells of undetermined significance (hereafter ASC-US cytology).

    Objective: To examine 5-year outcomes after ASC-US cytology with vs without HPV testing.

    Design, Setting, And Participants: In this observational study, all cervical cytology and HPV testing reports from January 1, 2007, to December 31, 2012, were obtained for women throughout New Mexico and linked to pathology reports. Read More

    Detection of Beta-Human Papillomavirus in a Child With Polyomavirus-Associated Trichodysplasia Spinulosa.
    Am J Dermatopathol 2017 Jun 20. Epub 2017 Jun 20.
    *Dermatology, Phlebology and Fluid Mechanics Laboratory, St Vincent's Centre for Applied Medical Research, Sydney, Australia; †Departments of Dermatology, Microbiology/Medical Genetics, and Internal Medicine, University of Texas Health Science Center, Houston, TX; and ‡Divisions of Dermatology and Dermatopathology, Albany Medical College, Albany, NY.
    Viral associated trichodysplasia spinulosa (VATS) is a rare cutaneous eruption characterized by folliculocentric papules, keratin spicules, and alopecia associated with trichodysplasia spinulosa-associated polyomavirus (TSPyV) infection. We report a case of a 6-year-old male child who presented with a generalized papular eruption during chemotherapy for acute lymphoblastic leukemia. The papules were tested for human papillomavirus (HPV) DNA by nested polymerase chain reaction (PCR) and TSPyV using PCR and gene sequencing studies. Read More

    Toll-like receptor 4 promotes proliferation and apoptosis resistance in human papillomavirus-related cervical cancer cells through the Toll-like receptor 4/nuclear factor-κB pathway.
    Tumour Biol 2017 Jun;39(6):1010428317710586
    1 Medical Center of Diagnosis and Treatment for Cervical Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
    Toll-like receptor 4 is overexpressed in various tumors, including cervical carcinoma. However, the role of Toll-like receptor 4 in cervical cancer remains controversial, and the underlying mechanisms are largely elusive. Therefore, Toll-like receptor 4 in cervical cancer and related mechanisms were investigated in this study. Read More

    Health-related quality of life as measured by the EQ-5D in the prevention, screening and management of cervical disease: A systematic review.
    Qual Life Res 2017 Jun 26. Epub 2017 Jun 26.
    Institute of Health & Society, Newcastle University, Newcastle upon Tyne, UK.
    Purpose: Cost-effectiveness analyses (CEAs) of screening can be highly sensitive to the health-related quality of life (HRQoL) effects of screen tests and subsequent treatment. Accordingly, accurate assessment of HRQoL is essential. We reviewed the literature regarding HRQoL in cervical prevention and management in order to appraise the current evidence regarding this important input to CEA. Read More

    Talking about human papillomavirus and cancer: development of consultation guides through lay and professional stakeholder coproduction using qualitative, quantitative and secondary data.
    BMJ Open 2017 Jun 26;7(6):e015413. Epub 2017 Jun 26.
    North Wales Centre for Primary Care Research, Bangor University, Bangor, UK.
    Background: High-risk human papillomaviruses (HPVs) cause all cervical cancer and the majority of vulvar, vaginal, anal, penile and oropharyngeal cancers. Although HPV is the most common sexually transmitted infection, public awareness of this is poor. In addition, many clinicians lack adequate knowledge or confidence to discuss sexual transmission and related sensitive issues. Read More

    Determinants of human papillomavirus vaccination uptake among adolescent girls: A theory-based longitudinal study among Hong Kong Chinese parents.
    Prev Med 2017 Jun 23. Epub 2017 Jun 23.
    Division of Behavioural Sciences, School of Public Health, University of Hong Kong, Hong Kong. Electronic address:
    Human papillomavirus (HPV) vaccination uptake among Chinese adolescent girls remains extremely low. This two-year longitudinal study examined theoretical predictors of adolescent girls' HPV vaccination uptake using an extended Theory of Planned Behaviour (TPB). Between February and November 2014, a random sample of 1996 (response rate 60%) Hong Kong Chinese parents of 12- to 17-year-old HPV unvaccinated girls completed baseline telephone interviews assessing attitudes and intention towards HPV vaccination. Read More

    Implementation of a human papillomavirus vaccination demonstration project in Malawi: successes and challenges.
    BMC Public Health 2017 Jun 26;17(1):599. Epub 2017 Jun 26.
    Ministry of Health, Reproductive Health Directorate, Lilongwe, Malawi.
    Background: Cervical cancer is a major public health problem in Malawi. The age-standardized incidence and mortality rates are estimated to be 75.9 and 49. Read More

    Evaluation of the impact of tumor HPV status on outcome in patients with locally advanced unresectable head and neck squamous cell carcinoma (HNSCC) receiving cisplatin, 5-fluorouracil with or without docetaxel: A subset analysis of EORTC 24971 study.
    Ann Oncol 2017 Jun 23. Epub 2017 Jun 23.
    Medical Oncology, Antwerp University Hospital, Edegem, Belgium.
    Background: EORTC 24971 was a phase III trial demonstrating superiority of induction regimen TPF over PF, in terms of progression-free (PFS) and overall survival (OS) in locoregionally advanced unresectable HNSCC. We conducted a retrospective analysis of prospectively collected data aiming to evaluate whether only HPV(-) patients (pts) benefit from adding docetaxel to PF, in which case de-intensifying induction treatment in HPV(+) pts could be considered.

    Methods: Pre-therapy tumor biopsies (blocks or slides) were assessed for high-risk HPV by p16 immunohistochemistry, PCR and qPCR. Read More

    The economic burden of human papillomavirus-related precancers and cancers in Sweden.
    PLoS One 2017 26;12(6):e0179520. Epub 2017 Jun 26.
    Department of Obstetrics and Gynecology, Skånes University Hospital, Lund University, Lund, Sweden.
    Background: High-risk (HR) human papillomavirus (HPV) infection is an established cause of malignant disease. We used a societal perspective to estimate the cost of HR HPV-related cervical, vulvar, vaginal, anal, and penile precancer and cancer, and oropharyngeal cancer in Sweden in 2006, 1 year before HPV vaccination became available in the country.

    Materials And Methods: This prevalence-based cost-of-illness study used diagnosis-specific data from national registries to determine the number of HR HPV-related precancers and cancers. Read More

    Distant metastases in head and neck cancer.
    Head Neck 2017 Jun 26. Epub 2017 Jun 26.
    Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
    Background: Most trials in head and neck cancer emphasize locoregional control, as this is the main pattern of therapy failure. However, up to 15% of patients develop distant metastases. The purpose of this study was to present the investigated factors associated with distant metastasis in a single-center patient cohort. Read More

    Urgent need to strengthen and expand screening and other cancer control programs in the CARICOM Caribbean.
    Cancer Causes Control 2017 Jun 26. Epub 2017 Jun 26.
    Faculty of Medical Sciences, University of the West Indies, St. Augustine, Trinidad & Tobago.
    Purpose: With high mortality in breast, cervical, prostate, and colorectal cancers in Caribbean Community (CARICOM) countries, we examined cancer control initiatives including screening as well as the implementation of relevant international and regional mandates.

    Methods: Secondary data were used to examine cancer control initiatives, which included the presence of national policies, programs, and screening services as well as the implementation of international and regional mandates. To identify the data, an on-line search was conducted using Google/Google Scholar. Read More

    Neck metastasis in patients with T1-2 supraglottic cancer.
    Auris Nasus Larynx 2017 Jun 22. Epub 2017 Jun 22.
    Department of Otolaryngology Head and Neck Surgery and Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Kita-Ku, Okayama City, 700-8558 Okayama, Japan; Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama, Japan.
    Objectives: Unlike glottic cancer, supraglottic cancer often presents with neck metastases. This different might be attributable to the location of the primary lesion. This study aimed to clarify the relationships between the sublocation of T1-2 supraglottic cancer, human papillomavirus (HPV) infection, neck metastasis, and prognosis of supraglottic cancer. Read More

    HPV vaccination and risk of chronic fatigue syndrome/myalgic encephalomyelitis: A nationwide register-based study from Norway.
    Vaccine 2017 Jun 22. Epub 2017 Jun 22.
    Department of Infectious Disease Epidemiology and Modelling, Norwegian Institute of Public Health, PO Box 4404 Nydalen, 0403 Oslo, Norway. Electronic address:
    Background: Vaccination has been suggested to be involved in the aetiology of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). HPV vaccine was introduced in the Norwegian Childhood Immunisation Programme and offered 12year old girls from 2009. We studied the association between HPV vaccination and risk of CFS/ME and also assessed medical history in relation to both risk of CFS/ME and HPV vaccine uptake. Read More

    [Human papillomavirus and oropharyngeal cancer].
    Ugeskr Laeger 2017 Jun;179(25)
    The prevalence of oropharyngeal cancer is increasing in the Western world, and human papillomavirus (HPV) is believed to play a role in this development. Patients with HPV-positive oropharyngeal cancer differ significantly from patients with HPV-negative cancer. They may present solely with a small cervical metastasis and thus undergo an extensive diagnostic workup. Read More

    Human papillomavirus infection increases the chemoradiation response of esophageal squamous cell carcinoma based on P53 mutation.
    Radiother Oncol 2017 Jun 21. Epub 2017 Jun 21.
    Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, PR China. Electronic address:
    Background And Purpose: A retrospective study was carried out to analyze multiple prognostic predictors, including human papillomavirus (HPV) infection for chemoradiation treatment of esophageal squamous cell carcinoma (ESCC).

    Materials And Methods: DNA extracted from a total of 192 patients treated with chemoradiation for locally advanced ESCC was examined to determine HPV status by polymerase chain reaction (PCR) and P53 gene mutation by genetic sequencing. The relationships between the chemoradiation response (CRR) and overall survival (OS) rate with HPV status and P53 gene mutation were analyzed. Read More

    Morphological characteristics and HPV genotype predict the treatment response in cutaneous warts.
    Br J Dermatol 2017 Jun 24. Epub 2017 Jun 24.
    Department of Dermatology, Leiden University Medical Centre, Leiden, The Netherlands.
    Background: Cutaneous warts have a cure rate after therapy of no more than approximately 50%. Recently, we developed and validated a standard assessment tool for warts (CWARTS) based on phenotypical characteristics.

    Objectives: To assess whether patient and morphological wart characteristics predict the HPV type in the specific wart and whether these characteristics as well as the HPV type predict a favourable treatment response. Read More

    Genetic variants in microRNA-binding sites of DNA repair genes as predictors of recurrence in patients with squamous cell carcinoma of the oropharynx.
    Int J Cancer 2017 Jun 24. Epub 2017 Jun 24.
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    The incidence of squamous cell carcinoma of the oropharynx (SCCOP) continues to rise because of increasing rates of human papillomavirus (HPV) infection. Inherited polymorphisms in DNA repair pathways may influence the risk of SCCOP development and the prognosis of SCCOP. We sought to determine whether polymorphisms in microRNA (miRNA)-binding sites within 3'-untranslated regions (3'UTRs) of genes in DNA repair pathways modulate the risk of SCCOP recurrence. Read More

    Comparing self- and provider-collected swabbing for HPV DNA testing in female-to-male transgender adult patients: a mixed-methods biobehavioral study protocol.
    BMC Infect Dis 2017 Jun 23;17(1):444. Epub 2017 Jun 23.
    Harvard Medical School, 25 Shattuck St, Boston, MA, 02215, USA.
    Background: Cervical cancer, nearly all cases of which are caused by one of several high-risk strains of the human papillomavirus (hr-HPV), leads to significant morbidity and mortality in individuals with a cervix. Trans masculine (TM) individuals were born with female reproductive organs and identify as male, man, transgender man, or another diverse gender identity different from their female assigned sex at birth. Routine preventive sexual health screening of TM patients is recommended, including screening for cervical cancer and other sexually transmitted infections (STIs); however, as many as one in three TM patients are not up-to-date per recommended U. Read More

    Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus-Positive and Human Papillomavirus-Negative Tumors.
    Arch Pathol Lab Med 2017 Jun 23. Epub 2017 Jun 23.
    Context: - Cervical adenocarcinomas span a diverse group of tumors with several distinct histologic tumor types, which include endocervical, endometrioid, intestinal, villoglandular, gastric, signet ring, serous, clear cell, and mesonephric. Diagnosis of cervical adenocarcinoma, especially early diagnosis, poses a significant challenge.

    Objective: - To review the pathogenesis, diagnostic criteria, immunohistochemical markers, and differential diagnosis of various subtypes of human papillomavirus (HPV)-positive and HPV-negative cervical adenocarcinomas. Read More

    Current understanding of cancer stem cells: Review of their radiobiology and role in head and neck cancers.
    Head Neck 2017 Jun 23. Epub 2017 Jun 23.
    International Centre for Allied Health Evidence and Sansom Institute for Health Research, University of South Australia, Adelaide, Australia.
    Evidence of cancer cells that bear attributes analogous to those of normal stem cells has developed a hierarchical model of cancer's architecture and progression. This subset of cancer stem cells (CSCs) drives the progression and therapy resistance of cancers. Research to identify the phenotypes of these CSCs presents evidence of a subpopulation that is more resistant to therapy and may proliferate in response. Read More

    Prognostic value of HPV DNA status in cervical cancer before treatment: a systematic review and meta-analysis.
    Oncotarget 2017 Jun 16. Epub 2017 Jun 16.
    Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Institute of Radiotherapy and Oncology, Soochow University, Suzhou, Jiangsu 215004, China.
    Background: Human papillomavirus (HPV), has been recognized as an vital preliminary event in the oncogenesis of cervical cancer. But the prognostic value is not well defined, because of past studies showing conflicting results. So we conducted this meta-analysis to evaluate whether HPV DNA status was associated with prognosis in cervical cancer. Read More

    Human Papillomavirus Genotype Distribution Among 18,815 Women in 13 Korean Cities and Relationship With Cervical Cytology Findings.
    Ann Lab Med 2017 Sep;37(5):426-433
    MEDIcheck LAB, Korea Association of Health Promotion, Cheongju, Korea.
    Background: The prevalence and genotype distribution of Human papillomavirus (HPV) infection vary depending on geographical region and the immunity provided by vaccines. This study aimed to clarify the recent prevalence and genotype distribution of HPV according to age and cervical cytology findings in Korea.

    Methods: This study included 18,815 health examinees that underwent cervical cytology and HPV genotyping tests at 16 centers of Korean Association of Health Promotion in 13 cities in Korea, between January 2014 and October 2015. Read More

    Oral cancer screening practices of Canadian dental hygienists.
    Int J Dent Hyg 2017 Jun 23. Epub 2017 Jun 23.
    School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
    Purpose: This study investigates whether dental hygienists are routinely conducting oral cancer screenings (OCSs) as per their professional capability and responsibility. Factors that may mediate provision of OCSs, and ability to discuss sensitive topics with patients, are also examined.

    Methods: A pretested online questionnaire was sent via national and provincial regulatory bodies to target practicing registered dental hygienists across Canada. Read More

    An Interactive, Mobile-Based Tool for Personal Social Network Data Collection and Visualization Among a Geographically Isolated and Socioeconomically Disadvantaged Population: Early-Stage Feasibility Study With Qualitative User Feedback.
    JMIR Res Protoc 2017 Jun 22;6(6):e124. Epub 2017 Jun 22.
    University of Kentucky Rural Cancer Prevention Center, College of Public Health, University of Kentucky, Lexington, KY, United States.
    Background: Personal social networks have a profound impact on our health, yet collecting personal network data for use in health communication, behavior change, or translation and dissemination interventions has proved challenging. Recent advances in social network data collection software have reduced the burden of network studies on researchers and respondents alike, yet little testing has occurred to discover whether these methods are: (1) acceptable to a variety of target populations, including those who may have limited experience with technology or limited literacy; and (2) practical in the field, specifically in areas that are geographically and technologically disconnected, such as rural Appalachian Kentucky.

    Objective: We explored the early-stage feasibility (Acceptability, Demand, Implementation, and Practicality) of using innovative, interactive, tablet-based network data collection and visualization software (OpenEddi) in field collection of personal network data in Appalachian Kentucky. Read More

    Human Papillomavirus Vaccine Dose Effectiveness Against Incident Genital Warts in a Cohort of Insured US Females.
    Am J Epidemiol 2017 Jun 21. Epub 2017 Jun 21.
    We examined effectiveness of HPV vaccination by dose number and interval against incident genital warts in a cohort of 64,517 females in the United States during 8/2006-9/2012. Eligible females were classified into 0, 1-dose, 2-dose < 6 months apart, 2-dose ≥6 months apart, and 3-dose groups and followed until genital wart diagnosis, loss to follow-up, or end of study. Propensity score weights were used to balance baseline differences across groups. Read More

    No additional prognostic value for MRE11 in squamous cell carcinomas of the anus treated with chemo-radiotherapy.
    Br J Cancer 2017 Jun 22. Epub 2017 Jun 22.
    CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford OX3 7DQ, UK.
    Background: The majority of anal cancers (84-95%) are driven by infection with human papillomavirus (HPV). HPV-positive tumours show significantly better responses to chemo-radiotherapy when compared with HPV-negative tumours. HPV infection is linked to alterations in DNA damage response proteins, including MRE11. Read More

    Giving It Our Best Shot? Human Papillomavirus and Hepatitis B Virus Immunization Among Refugees, Massachusetts, 2011-2013.
    Prev Chronic Dis 2017 Jun 22;14:E50. Epub 2017 Jun 22.
    Refugee and Immigrant Health Program, Massachusetts Department of Public Health, Boston, Massachusetts.
    Introduction: The receipt rate of hepatitis B virus vaccine among adolescents in the United States is high, while the receipt rate of human papillomavirus vaccine is low. Rates have not been closely studied among refugees, whose home countries have high rates of disease caused by these viruses.

    Methods: We examined human papillomavirus and hepatitis B virus immunization rates among 2,269 refugees aged 9 to 26 years who resettled in Massachusetts from 2011 through 2013. Read More

    Identification of C/EBPα as a novel target of the HPV8 E6 protein regulating miR-203 in human keratinocytes.
    PLoS Pathog 2017 Jun 22;13(6):e1006406. Epub 2017 Jun 22.
    Institute of Virology, Saarland University, Homburg/Saar, Germany.
    Patients suffering from Epidermodysplasia verruciformis (EV), a rare inherited skin disease, display a particular susceptibility to persistent infection with cutaneous genus beta-human papillomavirus (beta-HPV), such as HPV type 8. They have a high risk to develop non-melanoma skin cancer at sun-exposed sites. In various models evidence is emerging that cutaneous HPV E6 proteins disturb epidermal homeostasis and support carcinogenesis, however, the underlying mechanisms are not fully understood as yet. Read More

    Management of proliferative verrucous leukoplakia: Justification for a conservative approach.
    Head Neck 2017 Jun 22. Epub 2017 Jun 22.
    Mersey Head and Neck Oncology Research Group (MHNORG), Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
    Background: Proliferative verrucous leukoplakia (PVL) is a progressive, multifocal, exophytic form of leukoplakia with high rates of malignant transformation. The purpose of this study was to evaluate a cohort of patients with PVL in a single tertiary referral clinic.

    Method: Cases meeting accepted diagnostic criteria were reviewed with regard to their pathology, demographic characteristics, management, and outcomes. Read More

    Oral and oropharyngeal papillomas are not associated with high-risk human papillomavirus infection.
    Eur Arch Otorhinolaryngol 2017 Jun 21. Epub 2017 Jun 21.
    Department of Laryngology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
    The role of different types of human papillomavirus (HPV) in the development of oral and oropharyngeal papillomas remains unclear. High-risk HPV (HR-HPV) was shown to be involved in the pathogenesis of significant proportion of squamous cell carcinomas of the oropharynx. In this study, we hypothesized that in some oropharyngeal papillomas, low-risk HPV (LR-HPV) and HR-HPV infection could co-exist, similar to what is observed in genital warts, and thus contribute to the elevated risk of malignancy. Read More

    Anogenital warts and other HPV-associated anogenital lesions in the HIV-positive patient: a systematic review and meta-analysis of the efficacy and safety of interventions assessed in controlled clinical trials.
    Sex Transm Infect 2017 Jun 21. Epub 2017 Jun 21.
    Division of Evidence-based Medicine (dEBM), Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Objectives: Anogenital warts (AGW, condylomata acuminata) and intraepithelial neoplasia (IEN) do not only impact health and social well-being, they are also associated with considerable costs for the healthcare systems. Immunocompromised and HIV-positive patients carry the highest epidemiological burden of human papillomavirus (HPV) infection and comprise a population specifically susceptible to treatment failures and recurrences. This systematic review aimed at identifying and appraising the available evidence from controlled studies of interventions for the treatment of AGW and IEN in immunocompromised patients. Read More

    Association between sexual mixing and genital warts in heterosexual men in Australia: the herd protection from the female human papillomavirus vaccination program.
    Sex Health 2016 Oct;13(5):489-490
    Melbourne Sexual Health Centre, Alfred Health, 580 Swanston Street, Carlton, Vic. 3053, Australia.
    Australian-born women aged ≤32 years were eligible for the free female human papillomavirus (HPV) vaccination program introduced in 2007. A total of 1165 heterosexual couples attending the Melbourne Sexual Health Centre between 2011 and 2014 were included in this analysis. Findings showed the odds of having penile warts was 0. Read More

    Experience and psychological impact of anal cancer screening in gay, bisexual and other men who have sex with men: a qualitative study.
    Psychooncology 2017 Jun 20. Epub 2017 Jun 20.
    The Kirby Institute, UNSW, Australia.
    Objective: Human papillomavirus (HPV)-related anal cancer rates are increasing and are particularly high in gay, bisexual and other men who have sex with men (GBM/MSM), especially HIV-positive individuals. Although screening programs for high-risk populations have been advocated, concerns about possible adverse psychological consequences exist. This study aimed to investigate GBM/MSM's experience, understanding and emotional response to screening techniques for anal cancer, to determine how best to minimise psychological distress in future programs. Read More

    Absence of γ-chain in keratinocytes alters chemokine secretion resulting in reduced immune cell recruitment.
    J Invest Dermatol 2017 Jun 17. Epub 2017 Jun 17.
    Institute of Immunity and Transplantation, University College London, London, United Kingdom; Department of Immunology, Royal Free Hospital Foundation Trust, London, United Kingdom. Electronic address:
    Loss of function mutations in the common gamma (γc) chain cytokine receptor subunit give rise to severe combined immunodeficiency (SCID) characterised by lack of T and natural killer cells and infant death from infection. Haematopoietic stem cell transplantation or gene therapy offer cure but despite successful replacement of lymphoid immune lineages a long-term risk of severe cutaneous human papilloma virus (HPV) infections persists, possibly related to persistent γc-deficiency in other cell types. Here we demonstrate that keratinocytes, the only cell type directly infected by HPV, express functional γc and its co-receptors. Read More

    Seropositivity to non-vaccine incorporated genotypes induced by the bivalent and quadrivalent HPV vaccines: A systematic review and meta-analysis.
    Vaccine 2017 Jun 17. Epub 2017 Jun 17.
    Virus Reference Department, Public Health England, London, UK. Electronic address:
    Background: Human papillomavirus vaccines have demonstrated remarkable efficacy against persistent infection and disease associated with vaccine-incorporated genotypes and a degree of efficacy against some genetically related, non-vaccine-incorporated genotypes. The vaccines differ in the extent of cross-protection against these non-vaccine genotypes. Data supporting the role for neutralizing antibodies as a correlate or surrogate of cross-protection are lacking, as is a robust assessment of the seroconversion rates against these non-vaccine genotypes. Read More

    Human papillomavirus related oropharyngeal cancer.
    Ann Oncol 2017 Jun 15. Epub 2017 Jun 15.
    Department of Medical Oncology, Catalan Institute of Oncology (ICO), IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain.
    High-risk (HR) human papillomavirus (HPV) is now recognised as the principal cause of the increasing incidence rates of oropharyngeal squamous cell carcinoma (OPSCC) in some parts of the world.The primary risk factor for developing HPV-related OPSCC is oral HPV-infection and the majority of oral HPV-infections are acquired by oral sex. Progression into a OPSCC includes persistent infection with evasion of immune response in the microenvironment, the activation of viral early genes (E6, E7) in basal epithelial cells, the deregulation of cell cycle and the accumulation of chromosomal instability. Read More

    Peritumoral Cuffing by T cell Tumor Infiltrating Lymphocytes Distinguishes HPV-Related Oropharyngeal Squamous Cell Carcinoma from Oral Cavity Squamous Cell Carcinoma.
    J Oral Pathol Med 2017 Jun 20. Epub 2017 Jun 20.
    Department of Otolaryngology, Northwestern University, Feinberg Medical School, Chicago, IL 60611, USA.
    Background: It is unclear why human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) has improved clinical behavior compared to HPV-negative HNSCC. We sought to better characterize the immune microenvironment of tongue cancers by examining the CD3 and CD8 TIL pattern in HPV-positive and -negative tumors.

    Methods: Histologic sections from 40 oral tongue and oropharyngeal cases were analyzed (n= 21 HPV DNA-positive, n= 19 HPV DNA-negative). Read More

    Acquired epidermodysplasia verruciformis occurring in a renal transplant recipient.
    Cutis 2017 May;99(5):E9-E12
    Department of Dermatology, Geisinger Medical Center, Danville, Pennsylvania, USA.
    Acquired epidermodysplasia verruciformis (EDV) is a rare condition occurring in patients with depressed cellular immunity, particularly individuals with human immunodeficiency virus (HIV). Acquired EDV is less commonly reported in recipients of stem cell or solid organ transplantation. This condition typically manifests within 5 years of initial immunosuppression and can present as multiple hypopigmented to red, tinea versicolor-like macules or as multiple verrucous, flat-topped papules distributed over the trunk, arms, and legs. Read More

    Recalcitrant giant condyloma acuminatum treated successfully with a novel combination of Mycobacterium indicus pranii immunotherapy and acitretin.
    Int J STD AIDS 2017 Jan 1:956462417694805. Epub 2017 Jan 1.
    1 Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Giant condyloma acuminatum occurs infrequently in children and adolescents. It is a challenging condition which is difficult to treat with both surgical and medical modalities. We present a case of a 15-year-old boy with giant condyloma acuminatum of the glans penis refractory to several therapeutic modalities. Read More

    Sexually Transmitted Infections: A Novel Screening Strategy for Improving Women's Health in Vulnerable Populations.
    Int J Mol Sci 2017 Jun 20;18(6). Epub 2017 Jun 20.
    Department of Biomedical Sciences for Health, University of Milan, Via C. Pascal 36, 20133 Milan, Italy.
    Background: Migrant women are one of the most vulnerable population to health problems and well-being. This study aimed at implementing a counseling and preventive strategy for sexually transmitted infections (STIs) in undocumented migrant women in Milan, Italy.

    Methods: Women (ages 18-65) were enrolled at the NAGA Centre (2012-2013) and asked for a urine sample in order to carry out molecular detection of Human papillomavirus (HPV), Chlamydia trachomatis (Ct), Trichomonas vaginalis (Tv), Neisseria gonorrhoeae (Ng)-DNA. Read More

    Self-collected cervicovaginal sampling for site-of-care primary HPV-based cervical cancer screening: a pilot study in a rural underserved Greek population.
    J Obstet Gynaecol 2017 Jun 20:1-6. Epub 2017 Jun 20.
    a 4th Department of Obstetrics and Gynecology , Hippokratio Hospital of Thessaloniki , Thessaloniki , Greece.
    In the present pilot study, the feasibility of a site-of-care cervicovaginal self-sampling methodology for HPV-based screening was tested in 346 women residing in underserved rural areas of Northern Greece. These women provided self-collected cervicovaginal sample along with a study questionnaire. Following molecular testing, using the cobas(®) HPV Test, Roche(®), HPV positive women, were referred to colposcopy and upon abnormal findings, to biopsy and treatment. Read More

    Anti-herpes simplex virus type 1 activity of Houttuynoid A, a new flavonoid from Houttuynia cordata Thunb.
    Antiviral Res 2017 Jun 16. Epub 2017 Jun 16.
    Guangdong South China United Vaccine Institute, Guangzhou, China; Sino-French Hoffmann Institute of Immunology, College of Basic Medical Science, Guangzhou Medical University, Guangzhou, China. Electronic address:
    Early events in herpes simplex virus type 1 (HSV-1) infection reactivate latent human immunodeficiency virus, Epstein-Barr virus, and human papillomavirus in the presence of acyclovir (ACV). The common use of nucleoside analog medications, such as ACV and pencyclovir, has resulted in the emergence of drug-resistant HSV-1 strains in clinical therapy. Therefore, new antiherpetics that can inhibit early events in HSV-1 infection should be developed. Read More

    Human Papillomavirus and Its Testing Assays, Cervical Cancer Screening, and Vaccination.
    Adv Clin Chem 2017 18;81:135-192. Epub 2017 Mar 18.
    Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
    Human papillomavirus (HPV) was found to be the causative agent for cervical cancer in the 1980s with almost 100% of cervical cancer cases testing positive for HPV. Since then, many studies have been conducted to elucidate the molecular basis of HPV, the mechanisms of carcinogenesis of the virus, and the risk factors for HPV infection. Traditionally, the Papanicolaou test was the primary screening method for cervical cancer. Read More

    Characteristics and Distribution of Penile Lesions in Croatian Men with Laboratory-Confirmed Low-Risk and High-Risk Human Papillomavirus (HPV) Infection.
    Clin Lab 2017 May;63(5):971-981
    Background: Studies that compare penoscopic evaluation with the results of molecular human papillomavirus (HPV) testing are scarce. This study assessed and compared both type and distribution of various penile lesions using penoscopy (peniscopy) technique in Croatian men with different, laboratory-confirmed HPV status.

    Methods: From a large cohort of men attending an outpatient STD clinic for HPV testing, a total of 120 patients were randomly selected and grouped into those positive for low-risk HPV, high-risk HPV, both low-risk and highrisk HPV, and those with negative results. Read More

    Human papillomavirus (HPV) in young women in Britain: Population-based evidence of the effectiveness of the bivalent immunisation programme and burden of quadrivalent and 9-valent vaccine types.
    Papillomavirus Res 2017 Jun;3:36-41
    Research Department of Infection & Population Health, University College London, Mortimer Market Centre, London WC1E 6JB, UK.
    Background: In 2008, the UK introduced an HPV immunisation programme in girls. Population-based prevalence estimates of bivalent (HPV-16/18), quadrivalent (HPV-6/11/16/18) and 9-valent (HPV-6/11/16/18/31/33/45/52/58) vaccine types, and comparison over time, are needed to monitor impact, evaluate effectiveness and guide decision-making on vaccination strategies.

    Methods: The third National Survey of Sexual Attitudes and Lifestyles (Natsal-3) in 2010-12, tested urine for HPV from 2569 sexually-experienced women aged 16-44. Read More

    Involvement of the Toll-Like Receptor/Nitric Oxide Signaling Pathway in the Pathogenesis of Cervical Cancer Caused by High-Risk Human Papillomavirus Infection.
    Biomed Res Int 2017 24;2017:7830262. Epub 2017 May 24.
    Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
    Human papillomavirus (HPV) can activate Toll-like receptor (TLR)/nitric oxide (NO) signaling pathways; however, whether the TLR/NO pathway is involved in cervical cancer caused by high-risk HPV (HR-HPV) remains unclear. In this study, 43 HR-HPV-positive patients with cervical cancer (CC group), 39 HR-HPV-positive patients with a healthy cervix (HR-HPV group), and 33 HR-HPV-negative controls were recruited. NO concentration in cervical canal and expression of inducible NO synthase (iNOS) in cervical tissues were detected. Read More

    High-Risk Human Papillomavirus E7 Alters Host DNA Methylome and Represses HLA-E Expression in Human Keratinocytes.
    Sci Rep 2017 Jun 16;7(1):3633. Epub 2017 Jun 16.
    Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
    Human papillomavirus (HPV) infection distinctly alters methylation patterns in HPV-associated cancer. We have recently reported that HPV E7-dependent promoter hypermethylation leads to downregulation of the chemokine CXCL14 and suppression of antitumor immune responses. To investigate the extent of gene expression dysregulated by HPV E7-induced DNA methylation, we analyzed parallel global gene expression and DNA methylation using normal immortalized keratinocyte lines, NIKS, NIKS-16, NIKS-18, and NIKS-16∆E7. Read More

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