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    Evaluating Global Health Partnerships: A Case Study of a Gavi HPV Vaccine Application Process in Uganda.
    Int J Health Policy Manag 2016 Oct 26;6(6):327-338. Epub 2016 Oct 26.
    Management Sciences for Health, Arlington, VA, USA.
    Background: Global health partnerships have grown rapidly in number and scope, yet there has been less emphasis on their evaluation. Gavi, the Vaccine Alliance, is one such public-private partnership; in Gavi-eligible countries partnerships are dynamic networks of immunization actors who work together to support all stages and aspects of Gavi support. This paper describes a conceptual framework - the partnership framework - and analytic approach for evaluating the perceptions of partnerships' added value as well as the results from an application to one case in Uganda. Read More

    The role of human papillomavirus on the prognosis and treatment of oropharyngeal carcinoma.
    Cancer Metastasis Rev 2017 Aug 15. Epub 2017 Aug 15.
    Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, 601 N. Caroline Street, Sixth Floor, Baltimore, MD, 21287, USA.
    Human papillomavirus positive oropharyngeal cancer (HPV-positive OPC) is a distinct subtype of head and neck carcinoma (HNC) distinguished from HPV-negative HNC by its risk factor profile, clinical behavior, and molecular biology. Compared to HPV-negative HNC, HPV-positive OPC exhibits significantly better prognosis and an enhanced response to treatment. Recognition of the survival benefit of HPV-positive tumors has led to therapeutic de-intensification strategies aiming to mitigate treatment-related toxicities while maintaining high response rates. Read More

    Safety of Human Papillomavirus 9-Valent Vaccine: A Meta-Analysis of Randomized Trials.
    J Immunol Res 2017 24;2017:3736201. Epub 2017 Jul 24.
    Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
    Vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries for approximately 10 years. In order to increase the protection of the vaccines, a 9-valent vaccine (HPV9) was developed, which provides protection against nine types of the virus. Studies evaluating its safety are rare. Read More

    Influence of Human Papillomavirus Infection on the Natural History of Cervical Intraepithelial Neoplasia 1: A Meta-Analysis.
    Biomed Res Int 2017 24;2017:8971059. Epub 2017 Jul 24.
    Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
    Objective: To provide a scientific basis for the prevention and treatment of cervical intraepithelial neoplasia grade 1 (CIN1). This study evaluated the impact of human papillomavirus (HPV) infection on the natural history of CIN1.

    Methods: Electronic databases of Cochrane Library, EMBASE, PubMed, CNKI, CBM, and Wanfang were searched in April 2016. Read More

    ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism.
    Oncoimmunology 2017 20;6(7):e1336594. Epub 2017 Jun 20.
    Immunotherapy & Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Immune evasion of tumors poses a major challenge for immunotherapy. For human papillomavirus (HPV)-induced malignancies, multiple immune evasion mechanisms have been described, including altered expression of antigen processing machinery (APM) components. These changes can directly influence epitope presentation and thus T-cell responses against tumor cells. Read More

    SLPI and AnxA2 expression in neoplasm-free palatine tonsils is associated with smoking habit of individuals.
    Mol Clin Oncol 2017 Sep 24;7(3):427-434. Epub 2017 Jul 24.
    Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts University, D-24105 Kiel, Germany.
    In order to confirm the inverse correlation between secretory leucocyte protease inhibitor (SLPI) expression, and human papillomavirus (HPV) infection previously observed in head and neck squamous-cell carcinoma, the present study retrospectively investigated the association between SLPI and Annexin A2 (AnxA2) expression, and HPV status in non-neoplastic chronic tonsillitis (n=118), and tonsillar hyperplasia (n=96) tissue. We hypothesised that smoking induces the upregulation of SLPI, resulting in reduced binding of HPV to AnxA2, a known modulator of HPV entry into the cell. SLPI and cyclin-dependent kinase inhibitor 2A (p16(INK4A)) protein expression was measured using immunohistochemistry in 214 specimens; SLPI and AnxA2 gene expression was measured using reverse transcription-quantitative polymerase chain reaction in 213 cases; and DNA was isolated from all the specimens to determine HPV status. Read More

    The cytotoxic mechanism of epigallocatechin gallate on proliferative HaCaT keratinocytes.
    J Biomed Sci 2017 Aug 15;24(1):55. Epub 2017 Aug 15.
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, 114, Taiwan, Republic of China.
    Background: Epigallocatechin gallate (EGCG) is the major ingredient of sinecatechins ointment, approved for the treatment of external genital and perianal warts. However, the molecular mechanism for EGCG's effect on warts resulting from the human papillomavirus (HPV) infection of keratinocytes is not well understood. HPV may survive in proliferative keratinocytes and may be involved in cell cycle regulation and progression. Read More

    Human papillomavirus vaccine information, motivation, and behavioral skills among young adult US women.
    J Health Psychol 2016 Oct 1:1359105316672924. Epub 2016 Oct 1.
    1 Department of Community and Family Health, College of Public Health, University of South Florida,USA.
    This study elicited the information needs, motivations, and behavioral skills related to human papillomavirus vaccine decision-making among young adult women. Interviews were conducted with college women, aged 18-26 years, and stratified by recently vaccinated ( N = 25) and unvaccinated ( N = 25). Comparative thematic analysis using the Information, Motivation, and Behavioral Skills Model was conducted. Read More

    Transoral Resection of Human Papillomavirus (HPV)-Positive Squamous Cell Carcinoma of the Oropharynx: Outcomes with and Without Adjuvant Therapy.
    Ann Surg Oncol 2017 Aug 14. Epub 2017 Aug 14.
    Head and Neck Surgery Center of Florida, Florida Hospital Celebration Health and Florida Hospital Cancer Institute, Celebration, FL, USA.
    Background: With the rise of oropharyngeal squamous cell carcinoma associated with human papillomavirus (HPV), appropriate treatment strategies continue to be tailored toward minimizing treatment while preserving oncologic outcomes. This study aimed to compare the outcomes for those undergoing transoral resection with or without adjuvant therapy for HPV-related oropharyngeal carcinoma.

    Methods: A case-match cohort analysis was performed at two institutions on patients with HPV-related oropharyngeal squamous cell carcinoma. Read More

    Racial Disparities in HPV-related Knowledge, Attitudes, and Beliefs Among African American and White Women in the USA.
    J Cancer Educ 2017 Aug 14. Epub 2017 Aug 14.
    Morehouse School of Medicine, Atlanta, Georgia, 660 Ralph McGill Blvd Apt 3318, Atlanta, GA, 30312, USA.
    The objective of this study was to assess the differences in HPV-related knowledge, attitudes, and beliefs among African American and non-Hispanic white women and to determine their communication preferences for cancer-related information. Data was obtained from the National Cancer Institute's (NCI) 2014 Health Interview National Trends Survey (HINTS), a cross-sectional survey of US adults 18 years of age or older. Descriptive statistics, bivariate, and multivariate logistic regression were used to identify differences in awareness and knowledge. Read More

    A comparison of concurrent cisplatin versus cetuximab with radiotherapy in locally-advanced head and neck cancer: A bi-institutional analysis.
    Rep Pract Oncol Radiother 2017 Sep-Oct;22(5):389-395. Epub 2017 Aug 2.
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO, USA.
    Aim: To present our experience comparing cisplatin- and cetuximab-based radiotherapy for locally-advanced head and neck squamous cell carcinoma.

    Background: The comparative effectiveness of cisplatin-based chemoradiotherapy (CRT) versus cetuximab-based bioradiotherapy (BRT) for locally-advanced head and neck squamous cell carcinoma (LAHNSCC) continues to be explored.

    Materials And Methods: Outcomes of LAHNSCC patients treated with CRT (125) or BRT (34) at two institutions were compared retrospectively, with attention to overall survival (OS), cancer-specific survival (CSS), locoregional control (LRC), and distant control (DC). Read More

    Human papillomavirus in oropharyngeal cancer in Canada: analysis of 5 comprehensive cancer centres using multiple imputation.
    CMAJ 2017 Aug;189(32):E1030-E1040
    Ontario Cancer Institute (Habbous, O'Sullivan, Huang, Liu) and Department of Biostatistics (Xu), Princess Margaret Cancer Centre, Toronto, Ont.; Radiation Oncology (Chu, Belayneh, Parliament), Cross Cancer Institute, Edmonton, Alta.; Department of Oncology (Lau, Hao), University of Calgary, Alberta Health Services, Calgary, Alta.; Department of Oncology (Schorr, Hao), Division of Medical Oncology, Tom Baker Cancer Centre, Calgary, Alta.; Division of Medical Oncology (Ha, Murray, Snow), Nova Scotia Cancer Centre, Dalhousie University, Halifax, NS; Department of Radiation Oncology (O'Sullivan, Huang), Department of Medicine (Liu) and Department of Epidemiology, Dalla Lana School of Public Health (Liu), University of Toronto, Toronto, Ont.; Medical Oncology (Cheung), BC Cancer Agency, Vancouver, BC
    Background: The incidence of oropharyngeal cancer has risen over the past 2 decades. This rise has been attributed to human papillomavirus (HPV), but information on temporal trends in incidence of HPV-associated cancers across Canada is limited.

    Methods: We collected social, clinical and demographic characteristics and p16 protein status (p16-positive or p16-negative, using this immunohistochemistry variable as a surrogate marker of HPV status) for 3643 patients with oropharyngeal cancer diagnosed between 2000 and 2012 at comprehensive cancer centres in British Columbia (6 centres), Edmonton, Calgary, Toronto and Halifax. Read More

    Emerging role of HPV self-sampling in cervical cancer screening for hard-to-reach women: Focused literature review.
    Can Fam Physician 2017 Aug;63(8):597-601
    Assistant Professor in the Department of Family and Community Medicine at the University of Toronto, a scientist at the Centre for Urban Health Solutions at St Michael's Hospital, and a staff physician for St Michael's Hospital Academic Family Health Team in Toronto.
    Objective: To provide a focused critical review of the literature on the acceptability, feasibility, and uptake of human papillomavirus (HPV) self-sampling among hard-to-reach women.

    Quality Of Evidence: A focused search to obtain relevant literature published in English between 1997 and 2015 was done using PubMed and EMBASE using search terms including HPV self-test or HPV self-sample or HPV kit in combination with acceptability or feasibility. Only studies that focused on never-screened or underscreened populations were included in this review. Read More

    Adjuvant HPV vaccination for anal cancer prevention in HIV-positive men who have sex with men: The time is now.
    Vaccine 2017 Aug 11. Epub 2017 Aug 11.
    Institute for Technology Assessment, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Importance: Outcomes of treating high-grade squamous intraepithelial lesions (HSIL), a precursor to anal cancer, remain uncertain. Emerging evidence shows that post HSIL treatment adjuvant quadrivalent human papillomavirus (qHPV) vaccination improves the effectiveness of treatment. However, no recommendations exist regarding the use of qHPV vaccine as an adjuvant form of therapy. Read More

    Computed Tomography Radiomics Predicts HPV Status and Local Tumor Control After Definitive Radiochemotherapy in Head and Neck Squamous Cell Carcinoma.
    Int J Radiat Oncol Biol Phys 2017 Jun 15. Epub 2017 Jun 15.
    Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
    Purpose: This study aimed to predict local tumor control (LC) after radiochemotherapy of head and neck squamous cell carcinoma (HNSCC) and human papillomavirus (HPV) status using computed tomography (CT) radiomics.

    Methods And Materials: HNSCC patients treated with definitive radiochemotherapy were included in the retrospective study approved by the local ethical commission (93 and 56 patients in the training and validation cohorts, respectively). Three hundred seventeen CT radiomic features, including those based on shape, intensity, texture, and wavelet transform, were calculated in the primary tumor region. Read More

    Evaluation of vaccination herd immunity effects for anogenital warts in a low coverage setting with human papillomavirus vaccine-an interrupted time series analysis from 2005 to 2010 using health insurance data.
    BMC Infect Dis 2017 Aug 14;17(1):564. Epub 2017 Aug 14.
    Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig, Germany.
    Background: Shortly after the human papillomavirus (HPV) vaccine recommendation and hence the reimbursement of vaccination costs for the respective age groups in Germany in 2007, changes in the incidence of anogenital warts (AGWs) were observed, but it was not clear at what level the incidence would stabilize and to what extent herd immunity would be present. Given the relatively low HPV vaccination coverage in Germany, we aimed to assess potential vaccination herd immunity effects in the German setting.

    Methods: A retrospective open cohort study with data from more than nine million statutory health insurance members from 2005 to 2010 was conducted. Read More

    Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study.
    PLoS Genet 2017 Aug 14;13(8):e1006866. Epub 2017 Aug 14.
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Australia.
    A small percentage of women with cervical HPV infection progress to cervical neoplasia, and the risk factors determining progression are incompletely understood. We sought to define the genetic loci involved in cervical neoplasia and to assess its heritability using unbiased unrelated case/control statistical approaches. We demonstrated strong association of cervical neoplasia with risk and protective HLA haplotypes that are determined by the amino-acids carried at positions 13 and 71 in pocket 4 of HLA-DRB1 and position 156 in HLA-B. Read More

    Risk of cancer in patients with genital warts: A nationwide, population-based cohort study in Taiwan.
    PLoS One 2017 14;12(8):e0183183. Epub 2017 Aug 14.
    Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.
    Background: Condyloma acuminata currently affects around 1% of sexually active adults, and its incidence is increasing. The coexistence of genital warts (GW) and certain cancers and an association between human papillomavirus (HPV) and various malignancies have been reported. Therefore, we conducted this large national study to analyze the risk of malignancies among men and women with GW in Taiwan. Read More

    On the association between human papillomavirus vaccine and sleep disorders: Evaluation based on vaccine adverse events reporting systems.
    J Neurol Sci 2017 Aug 4. Epub 2017 Aug 4.
    Scientific Institute, IRCCS E. Medea, Bosisio Parini, Lecco, Italy; Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, Consiglio Nazionale delle Ricerche Institute of Neuroscience, L. Sacco University Hospital, Università di Milano, Milan, Italy.

    Health Care Providers' Knowledge of HPV Vaccination, Barriers, and Strategies in a State With Low HPV Vaccine Receipt: Mixed-Methods Study.
    JMIR Cancer 2017 Aug 11;3(2):e12. Epub 2017 Aug 11.
    Cancer Control and Population Sciences Department, Huntsman Cancer Institute, Salt Lake City, UT, United States.
    Background: Human papillomavirus (HPV) vaccination is below national goals in the United States. Health care providers are at the forefront of improving vaccination in the United States, given their close interactions with patients and parents.

    Objective: The objective of this study was to assess the associations between demographic and practice characteristics of the health care providers with the knowledge of HPV vaccination and HPV vaccine guidelines. Read More

    Progress in prophylactic human papillomavirus (HPV) vaccination in 2016: A literature review.
    Vaccine 2017 Aug 8. Epub 2017 Aug 8.
    Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000 Ljubljana, Slovenia. Electronic address:
    Prophylactic human papillomavirus (HPV) vaccine represents a revolutionary step forward in preventing HPV-related cancers, especially cervical carcinoma. Alongside appropriate screening, it has the potential to dramatically reduce cervical cancer incidence and even eradicate it. Following extensive evaluations in clinical trials, the first decade of routine HPV vaccine use provides overwhelming evidence of the vaccines' safety and their real-life effectiveness. Read More

    Expression optimization of a cell membrane-penetrating human papillomavirus type 16 therapeutic vaccine candidate in Nicotiana benthamiana.
    PLoS One 2017 11;12(8):e0183177. Epub 2017 Aug 11.
    Biopharming Research Unit, Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, Cape Town, South Africa.
    High-risk human papillomaviruses (hr-HPVs) cause cervical cancer, the fourth most common cancer in women worldwide. A HPV-16 candidate therapeutic vaccine, LALF32-51-E7, was developed by fusing a modified E7 protein to a bacterial cell-penetrating peptide (LALF): this elicited both tumour protection and regression in pre-clinical immunization studies. In the current study, we investigated the potential for producing LALF32-51-E7 in a plant expression system by evaluating the effect of subcellular localization and usage of different expression vectors and gene silencing suppressors. Read More

    HPV-16 in a distinct subset of oral epithelial dysplasia.
    Mod Pathol 2017 Aug 11. Epub 2017 Aug 11.
    Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
    Human papillomavirus (HPV) 16 is the most common high-risk HPV type identified in oropharyngeal and cervical neoplasia. Recently, HPV-associated oral epithelial dysplasia with specific histopathologic features and demographics similar to HPV-oropharyngeal carcinoma has been identified. The objective of this study was to evaluate histopathologically all cases of HPV-oral epithelial dysplasia seen in one center and identify HPV types in a subset of cases. Read More

    Unusually high incidence of multifocal epithelial hyperplasia in children of the Nahuatl population of Mexico.
    Indian J Dermatol Venereol Leprol 2017 Aug 9. Epub 2017 Aug 9.
    Division Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, Mexico.
    Background: Multifocal epithelial hyperplasia is an uncommon disease of the oral mucosa caused by the human papilloma virus.

    Aim: To study the clinical and pathological findings of multifocal epithelial hyperplasia detected during an oral examination of 343 Mexican Nahuatl children from a single primary school in El Paso de Cupilco, Mexico.

    Methods: A thorough oral examination was performed in all children and clinical data (age, gender, location and number of lesions) were documented and analyzed. Read More

    Vulvar cancer in Germany: increase in incidence and change in tumour biological characteristics from 1974 to 2013.
    Acta Oncol 2017 Aug 11:1-7. Epub 2017 Aug 11.
    b Charité, Campus Benjamin Franklin, Clinic for Gynecology and Senology , Berlin , Germany.
    Background: The incidence of vulvar cancer in Germany is increasing. Moreover, gynaecological oncologists reported observing increasing numbers of women presenting with small tumours. The aim of the present study is to validate this observation on a population level and to extend available incidence data. Read More

    The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review.
    Clin Sci (Lond) 2017 Sep 10;131(17):2201-2221. Epub 2017 Aug 10.
    MRC-University of Glasgow Centre for Virus Research; Institute of Infection, Immunity and Inflammation; College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Glasgow G61 1QH, Scotland, U.K.
    HPVs (human papillomaviruses) infect epithelial cells and their replication cycle is intimately linked to epithelial differentiation. There are over 200 different HPV genotypes identified to date and each displays a strict tissue specificity for infection. HPV infection can result in a range of benign lesions, for example verrucas on the feet, common warts on the hands, or genital warts. Read More

    nab-Paclitaxel-based induction chemotherapy with or without cetuximab for locally advanced head and neck squamous cell carcinoma.
    Oral Oncol 2017 Sep 8;72:26-31. Epub 2017 Jul 8.
    Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, United States; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, United States.
    Objectives: To explore the effect of incorporating cetuximab into induction chemotherapy in locally advanced head and neck squamous cell carcinoma (HNSCC).

    Materials And Methods: Retrospective comparative analysis of two consecutive prospective phase II trials was performed: trial 1 with nab-paclitaxel/cisplatin/5-FU and cetuximab (APF-C; n=30) and trial 2 with APF (n=30). Patients were scheduled to receive chemoradiation therapy (CRT) with cisplatin. Read More

    Evaluation of the Xpert® HPV assay in the detection of Human Papillomavirus in formalin-fixed paraffin-embedded oropharyngeal carcinomas.
    Oral Oncol 2017 Sep;72:117-122
    Pathology Department, Regina Elena National Cancer Institute, IRCCS, Via Elio Chianesi 53, 00144 Rome, Italy. Electronic address:
    Objectives: The increasing incidence of HPV-related Oropharyngeal Squamous Cell Carcinoma (OPSCC) and the improved survival of HPV-positive OPSCC highlight the need for effective tools in evaluating HPV status on formalin-fixed paraffin-embedded (FFPE) cancers. To date, there is no agreement regarding the most appropriate method for HPV testing on FFPE materials. We aimed to investigate the performance of the Xpert® HPV assay (Cepheid) on crude lysates from OPSCC FFPE tissues. Read More

    Health care providers' perceptions of use and influence of clinical decision support reminders: qualitative study following a randomized trial to improve HPV vaccination rates.
    BMC Med Inform Decis Mak 2017 Aug 10;17(1):119. Epub 2017 Aug 10.
    Regenstrief Institute, Inc., Center for Biomedical Informatics, 1101 W. 10th St, Indianapolis, IN, 46202, USA.
    Background: Human Papillomavirus (HPV) leads to serious health issues and remains the most common sexually transmitted infection. Despite availability of effective vaccines, HPV vaccination rates are suboptimal. Furthermore, providers recommend the HPV vaccine less than half the time for eligible patients. Read More

    Facilitators and barriers to the acceptance of human papillomavirus (HPV) vaccination among adolescent girls: a comparison between mothers and their adolescent daughters in Hong Kong.
    BMC Res Notes 2017 Aug 10;10(1):390. Epub 2017 Aug 10.
    School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
    Background: The aim of this study is to examine knowledge and attitude as facilitators and barriers to the acceptance of HPV vaccination for adolescent girls by mothers and adolescent girls.

    Methods: A cross-sectional survey conducted in Hong Kong in January 2010. Adolescent girls aged 12-18, together with their mothers, were recruited to complete two separate questionnaires with similar questions. Read More

    [To analyse the histopathological results of patients with HPV16/18 positive and colposcopic suspicious lesions].
    Zhonghua Fu Chan Ke Za Zhi 2017 Jul;52(7):467-472
    Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China.
    Objective: To explore the value of histopathologic diagnosis after colposcopy for high-risk HPV16/18 positive patients with negative cytology or atypical squamous cells of undetermined significance (ASCUS) for early screening of cervical lesions. Methods: A retrospective study of cervical histopathologic diagnosis in the HPV16/18 positive patients received colposcopy evaluation before got the histology was carried out between January 2014 and January 2016. The cytology of the patients should be negative or ASCUS. Read More

    Epithelial-to-mesenchymal transition contributes to invasion in squamous cell carcinomas originated from actinic keratosis through the differentiated pathway whereas proliferation plays a more significant role in the classical pathway.
    J Eur Acad Dermatol Venereol 2017 Aug 10. Epub 2017 Aug 10.
    Universitat Autònoma de Barcelona.
    Background: Every actinic keratosis (AK) starts with atypia at the basal layers of the epidermis (AK I). Progression into invasive squamous cell carcinoma (iSCC) may occur following two main pathways, classical and differentiated. In the former, iSCC only occurs after involvement of the upper epidermal layers by atypical cells (AK III), while in the latter iSCC develops directly from AK I. Read More

    Cytology versus HPV testing for cervical cancer screening in the general population.
    Cochrane Database Syst Rev 2017 Aug 10;8:CD008587. Epub 2017 Aug 10.
    Department of Obstetrics and Gynaecology, Elena Venizelou Maternity Hospital, 1 Elena Venizelou Square, Athens, Greece, 11521.
    Background: Cervical cancer screening has traditionally been based on cervical cytology. Given the aetiological relationship between human papillomavirus (HPV) infection and cervical carcinogenesis, HPV testing has been proposed as an alternative screening test.

    Objectives: To determine the diagnostic accuracy of HPV testing for detecting histologically confirmed cervical intraepithelial neoplasias (CIN) of grade 2 or worse (CIN 2+), including adenocarcinoma in situ, in women participating in primary cervical cancer screening; and how it compares to the accuracy of cytological testing (liquid-based and conventional) at various thresholds. Read More

    Maternal and Infant Outcomes After Human Papillomavirus Vaccination in the Periconceptional Period or During Pregnancy.
    Obstet Gynecol 2017 Aug 4. Epub 2017 Aug 4.
    Department of Obstetrics, Gynecology, & Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut; HealthPartners Institute, Minneapolis, Minnesota; the Department of Epidemiology, University of Iowa, Iowa City, Iowa; the Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon; the Vaccine Study Center, Kaiser Permanente Northern California, Oakland, California; the Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California; Group Health Research Institute, Seattle, Washington; the Institute for Health Research, Kaiser Permanente Colorado and Ambulatory Care Services, Denver Health, Denver, Colorado; Harvard Pilgrim Health Care Institute & Harvard Medical School, Boston, Massachusetts; and the Centers for Disease Control and Prevention, Atlanta, Georgia.
    Objective: To evaluate whether quadrivalent human papillomavirus (HPV) vaccine administered during the periconceptional period or during pregnancy was associated with increased risks for adverse obstetric events, adverse birth outcomes, or selected major structural birth defects.

    Methods: We conducted a retrospective, observational cohort study using administrative and health care data from the Vaccine Safety Datalink. Insured women 13-27 years old with singleton pregnancies and a live birth from January 1, 2007, through September 1, 2013, who received quadrivalent HPV vaccine during the periconceptional period (2 weeks before to 2 weeks after their last menstrual period), during pregnancy, or during both periods combined were compared with women who had a live birth during the same time period and received quadrivalent HPV vaccine 4-18 months before their last menstrual period. Read More

    Review of the current medical literature and assessment of current utilization patterns regarding human papillomavirus in situ hybridization and immunohistochemistry in dermatopathology.
    J Cutan Pathol 2017 Aug 10. Epub 2017 Aug 10.
    Departments of Dermatology and Pathology, Saint Louis University School of Medicine, 1755 South Grand Blvd., St. Louis, MO, 63104.
    Human papillomaviruses have been implicated in many cutaneous diseases. Practicing dermatopathologists often consider using immunohistochemistry and in situ hybridization to help clarify the histologic diagnosis, particularly in cases with borderline or non-diagnostic features. We reviewed the current evidence behind the use of these two techniques in dermatopathology. Read More

    Papillomavirus genotyping on formaldehyde fixed paraffin-embedded tissues in vulvar intraepithelial neoplasia.
    Arch Gynecol Obstet 2017 Aug 9. Epub 2017 Aug 9.
    Laboratoire Central d'Anatomie et Cytologie Pathologique, Centre Hospitalier Universitaire de Nice, Hôpital Pasteur 1, pavillon L, 30 Avenue de la Voie Romaine, 06000, Nice, France.
    Purpose: Few studies have described the epidemiology of human papillomavirus (HPV) in vulvar intraepithelial neoplasia (VIN). The aim of this study was to genotype HPV on formalin fixed paraffin-embedded tissues in VIN lesions.

    Methods: A 5-year retrospective study was conducted by including all patients attending the teaching hospital of Nice with a diagnosis of VIN between 1st January 2010 and 31st December 2014. Read More

    Human papillomavirus-driven immune deviation: challenge and novel opportunity for immunotherapy.
    Ther Adv Vaccines 2017 Jun 5;5(3):69-82. Epub 2017 Jul 5.
    Division of Molecular and Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Paterson Building, Wilmslow Road, Manchester, M20 4BX, UK.
    It is now recognized that the immune system can be a key component of restraint and control during the neoplastic process. Human papillomavirus (HPV)-associated cancers of the anogenital tract and oropharynx represent a significant clinical problem but there is a clear opportunity for immune targeting of the viral oncogene expression that drives cancer development. However, high-risk HPV infection of the target epithelium and the expression of the E6/E7 oncogenes can lead to early compromise of the innate immune system (loss of antigen-presenting cells) facilitating viral persistence and increased risk of cancer. Read More

    Ancient Evolution and Dispersion of Human Papillomavirus Type 58 Variants.
    J Virol 2017 Aug 9. Epub 2017 Aug 9.
    Department of Microbiology and Stanley Ho Center for Emerging Infectious Diseases, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    Human papillomavirus type 58 is found in 10-18% of cervical cancers in East Asia but rather uncommon elsewhere. The distribution and oncogenic potential of HPV58 variants appear to be heterogeneous since the E7 T20I/G63S variant is more prevalent in East Asia and confers 7-9 fold higher risk for cervical precancer and cancer. However, the underlying genomic mechanisms that explain the geographic and carcinogenic diversity of HPV58 variants are still poorly understood. Read More

    Human Papillomavirus and the Stroma: Bidirectional Crosstalk during the Virus Life Cycle and Carcinogenesis.
    Viruses 2017 Aug 9;9(8). Epub 2017 Aug 9.
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, WI 53705, USA.
    Human papillomaviruses (HPVs) are double-stranded DNA (dsDNA) tumor viruses that are causally associated with human cancers of the anogenital tract, skin, and oral cavity. Despite the availability of prophylactic vaccines, HPVs remain a major global health issue due to inadequate vaccine availability and vaccination coverage. The HPV life cycle is established and completed in the terminally differentiating stratified epithelia, and decades of research using in vitro organotypic raft cultures and in vivo genetically engineered mouse models have contributed to our understanding of the interactions between HPVs and the epithelium. Read More

    The role of human papillomavirus in oncogenic transformation and its contribution to the etiology of precancerous lesions and cancer of the larynx: A review.
    Adv Clin Exp Med 2017 May-Jun;26(3):539-547
    Departament of Histology and Embriology, Wroclaw Medical University, Poland.
    Human papillomavirus (HPV) belongs to the Papillomaviridae family and infects squamous cells and mucous membranes of humans. Various studies conducted over the last years have shown a correlation between HPV infection and carcinogenesis process. The DNA of the virus is detected in approximately 20% of cancers of the upper respiratory tract. Read More

    Atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion triage in Korean women: Revisiting the 2012 American Society of Colposcopy and Cervical Pathology screening guidelines.
    Obstet Gynecol Sci 2017 Jul 14;60(4):357-361. Epub 2017 Jul 14.
    Department of Obstetrics and Gynecology, Guro Hospital, Korea University College of Medicine, Seoul, Korea.
    Objective: To determine whether triage for atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL) from the updated American Society for Colposcopy and Cervical Pathology cervical cancer screening guidelines is applicable in Korean women.

    Methods: We investigated women with ASC-US or LSIL including referred from local hospitals visited for cervical cancer screening at Korea University Guro Hospital from February 2004 to December 2014. Detailed information on the results of Papanicolaou (Pap) smears, human papillomavirus (HPV) DNA tests, and cervical biopsies were collected through chart review. Read More

    Cervical cancer screening in low-resource settings: a smartphone image application as an alternative to colposcopy.
    Int J Womens Health 2017 22;9:455-461. Epub 2017 Jun 22.
    Department of Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.
    Background: Visual inspection after application of acetic acid (VIA) and Lugol's iodine (VILI) is a cervical cancer (CC) screening approach that has recently been adopted in low- and middle-income countries (LMIC). Innovative technologies allow the acquisition of consecutive cervical images of VIA and VILI using a smartphone application. The aim of this study was to evaluate the quality of smartphone images in order to assess the feasibility and usability of a mobile application for CC screening in LMIC. Read More

    Targeted human papillomavirus vaccination for young men who have sex with men in Australia yields significant population benefits and is cost-effective.
    Vaccine 2017 Aug 5. Epub 2017 Aug 5.
    Melbourne Sexual Health Centre, Alfred Health, Melbourne, Australia; Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
    Background: We investigated the effectiveness and cost-effectiveness of a targeted human papillomavirus (HPV) vaccination program for young (15-26) men who have sex with men (MSM).

    Methods: We developed a compartmental model to project HPV epidemic trajectories in MSM for three vaccination scenarios: a boys program, a targeted program for young MSM only and the combination of the two over 2017-2036. We assessed the gain in quality-adjusted-life-years (QALY) in 190,000 Australian MSM. Read More

    Antibody persistence and evidence of immune memory at 5years following administration of the 9-valent HPV vaccine.
    Vaccine 2017 Aug 5. Epub 2017 Aug 5.
    Merck & Co., Inc., Kenilworth, NJ, USA. Electronic address:
    Background: The 9-valent HPV (9vHPV) vaccine was developed to prevent infection and disease related to 9 HPV types (HPV6/11/16/18/31/33/45/52/58) which cause approximately 90% of cervical cancers, HPV-related vulvar, vaginal and anal cancers, and genital warts worldwide. In a pivotal efficacy study, the 9vHPV vaccine prevented infection and disease due to the 9 vaccine types. Duration of protection remains to be determined. Read More

    High prevalence of co-infection between human papillomavirus (HPV) 51 and 52 in Mexican population.
    BMC Cancer 2017 Aug 8;17(1):531. Epub 2017 Aug 8.
    Departamento de Investigación Clínica, Grupo Diagnóstico Médico Proa, 06400, CDMX, Mexico.
    Background: Human papillomavirus (HPV) is associated with the genesis of cervical carcinoma. The co-infection among HPV genotypes is frequent, but the clinical significance is controversial; in Mexico, the prevalence and pattern of co-infection differ depending on the geographic area of study. We analyzed the mono- and co-infection prevalence of multiple HPV genotypes, as well as preferential interactions among them in a Mexico City sample population. Read More

    Association between human papillomavirus and prostate cancer: A meta-analysis.
    Oncol Lett 2017 Aug 9;14(2):1855-1865. Epub 2017 Jun 9.
    Department of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.
    Observational studies have suggested an association between human papillomavirus (HPV) infection and the risk of prostate cancer (PCa). However, the association between HPV infection and the risk of PCa remains unclear. The aim of the present meta-analysis study was to investigate whether HPV serves a role in increasing the risk of PCa. Read More

    IMP3 and p16 expression in squamous cell carcinoma of the head and neck: A comparative immunohistochemical analysis.
    Oncol Lett 2017 Aug 8;14(2):1665-1670. Epub 2017 Jun 8.
    Institute of Pathology, University Hospital, Friedrich-Alexander University Erlangen-Nuremberg, D-91054 Erlangen, Germany.
    Expression of p16 has been established as a good surrogate marker for high-risk human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) patients, and it has been associated with an improved prognosis, irrespective of the actual HPV status. Conversely, the human insulin-like growth factor II mRNA binding protein 3 (IMP3) has been related to aggressiveness in several types of tumors. The aim of the present study was to investigate and compare p16 and IMP3 as markers of favorable and unfavorable behavior, respectively, in head and neck SCC (HNSCC), with particular reference to the HPV status. Read More

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