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    Corrigendum to "Prevalence of human papillomavirus genotypes, and mucosal IgA anti-viral responses in women with cervical ectopy" [J. Clin. Virol. 47 (2010) 43-48].
    J Clin Virol 2017 Feb 20;89:38. Epub 2017 Feb 20.
    Departamento de Biologia Molecular y Biotecnología, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Circuito Escolar s/n Ciudad Universitaria, Mexico D.F., C.P. 04510, Mexico. Electronic address:

    Exploring Human Papillomavirus Vaccination Refusal Among Ethnic Minorities in England: A Comparative Qualitative Study.
    Psychooncology 2017 Feb 23. Epub 2017 Feb 23.
    Behavioural Science and Health, UCL, London, United Kingdom.
    Objectives: In England, uptake of human papillomavirus (HPV) vaccination to prevent HPV-related cancer is lower among girls from ethnic minority backgrounds. We aimed to explore the factors that prevented ethnic minority parents from vaccinating, compared to White British non-vaccinating parents and vaccinating ethnic minority parents.

    Methods: Interviews with 33 parents (n = 14 ethnic minority non-vaccinating, n = 10 White British non-vaccinating, n = 9 ethnic minority vaccinating) explored parents' reasons for giving or withholding consent for HPV vaccination. Read More

    Prevalence of HPV 16 and 18 and attitudes toward HPV vaccination trials in patients with cervical cancer in Mali.
    PLoS One 2017 23;12(2):e0172661. Epub 2017 Feb 23.
    Laboratory of Applied Molecular Biology (LBMA), Science and Technologies Faculty (FST), University of Science Techniques and Technologies of Bamako (USTTB), Bamako, Mali.
    Background: Cervical cancer is one of the most common and lethal cancers in West Africa. Even though vaccines that protect against the most common Human papillomavirus (HPV) strains, 16 and 18, are currently in use in developed countries, the implementation of these vaccines in developing countries has been painfully slow, considering the pre-eminence of HPV-associated cervical cancer among women in those countries.

    Aim: We performed serological and PCR-based assessment of blood and tissue specimens obtained from women undergoing cervical cancer-related surgery at a major urban hospital in Bamako. Read More

    Investigation of p16 status, chemotherapy regimen, and other nutrition markers for predicting gastrostomy in patients with head and neck cancer.
    Head Neck 2017 Feb 23. Epub 2017 Feb 23.
    Centre for Dietetic Research (C-DIET-R), School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Australia.
    Background: The purpose of this study was to determine if p16 status, chemotherapy regimen, or other nutrition markers could improve protocol accuracy in predicting proactive gastrostomy in patients with head and neck cancer.

    Methods: Patients who received curative treatment from July 2010 to June 2011 were included (n = 269). Associations among dependent variables (age, sex, tumor site, staging, treatment, p16 status, albumin, and Malnutrition Screening Tool [MST] score), the protocol risk rating, and requirement for proactive gastrostomy were examined. Read More

    Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain.
    Rev Esp Enferm Dig 2017 Feb 23. Epub 2017 Feb 23.
    Department of Medicine, Owen Clinic. University of California at San Diego, Estados Unidos.
    Background: Men who have sex with men (MSM) infected with human immunodeficiency virus (HIV) have the highest risk of developing anal cancer (AC). The objective of this study was to describe our screening implementation program in this population, and report the prevalence of human papillomavirus (HPV) anal infection, and cytological and histological findings in a Spanish medium-size community (Vigo, Spain).

    Method: Prospective cohort analysis of 240 HIV-infected MSM. Read More

    Effects of a non-thermal plasma needle device on HPV-16 positive cervical cancer cell viability in vitro.
    Conf Proc IEEE Eng Med Biol Soc 2016 Aug;2016:537-540
    Non-thermal atmospheric pressure plasma has been demonstrated to inactivate a wide range of surface-dwelling pathogenic microorganisms including airborne viral particles, vegetative bacteria and bacterial spores. This shows the promise of plasma-based decontamination procedures for broad-spectrum sterilization and disinfection and promotes the in-depth and systematic study of how plasma treatment conditions relate to pathogen inactivation efficiency. A wide knowledge gap nonetheless exists regarding whether certain plasma parameters and exposure conditions can alter the resistance of virus-linked cancer cells to treatment. Read More

    Betel nut chewing, oral premalignant lesions, and the oral microbiome.
    PLoS One 2017 22;12(2):e0172196. Epub 2017 Feb 22.
    University of Guam Cancer Research Center, Mangilao, Guam, United States of America.
    Oral cancers are attributed to a number of causal agents including tobacco, alcohol, human papillomavirus (HPV), and areca (betel) nut. Although betel nut chewing has been established as an independent cause of oral cancer, the mechanisms of carcinogenesis are poorly understood. An investigation was undertaken to evaluate the influence of betel nut chewing on the oral microbiome and oral premalignant lesions. Read More

    Immunostaining for High-Risk Human Papillomavirus in Condyloma Lesions in Immunocompromised Patients.
    Am J Clin Dermatol 2017 Feb 21. Epub 2017 Feb 21.
    Department of Dermatology, University of Pennsylvania, 3600 Spruce Street, 2 Maloney Building, Philadelphia, PA, 19104, USA.
    Background: Human papillomavirus (HPV) is the underlying infectious cause of condyloma acuminata (CA) and high-risk types of HPV can cause cancer. Condyloma may undergo malignant degeneration, particularly in immunosuppressed patients. The presence of high-risk HPV in CA is a risk factor for developing malignancy; however, determining which patients with condyloma are clinically at risk can be difficult. Read More

    Performance and Diagnostic Accuracy of a Urine-Based Human Papillomavirus Assay in a Referral Population.
    Cancer Epidemiol Biomarkers Prev 2017 Feb 21. Epub 2017 Feb 21.
    Trovagene, Inc.
    Background HPV testing from clinician-collected cervical and self-collected cervico-vaginal samples is more sensitive for detecting CIN2+/CIN3+ than cytology-based screening, stimulating interest in HPV testing from urine. The objective was to determine the performance of the Trovagene HPV test for the detection of CIN2+ from urine and PreservCyt cervical samples. Methods Women referred for colposcopy at St Mary's Hospital London, following abnormal cytology, were recruited to this diagnostic accuracy study by convenience sampling (September 2011 and April 2013). Read More

    Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
    Lancet Oncol 2017 Feb 17. Epub 2017 Feb 17.
    The University of Texas-MD Anderson Cancer Center, Houston, TX, USA. Electronic address:
    Background: Squamous cell carcinoma of the anal canal (SCCA) is a rare malignancy associated with infection by human papillomavirus (HPV). No consensus treatment approach exists for the treatment of metastatic disease. Because intratumoral HPV oncoproteins upregulate immune checkpoint proteins such as PD-1 to evade immune-mediated cytotoxicity, we did a trial of the anti-PD-1 antibody nivolumab for patients with metastatic SCCA. Read More

    A longitudinal study on determinants of HPV vaccination uptake in parents/guardians from different ethnic backgrounds in Amsterdam, the Netherlands.
    BMC Public Health 2017 Feb 21;17(1):220. Epub 2017 Feb 21.
    TNO (Netherlands Organization for Applied Scientific Research), Expertise Centre Child Health, Leiden, The Netherlands.
    Background: Human papillomavirus (HPV) vaccination coverage in the Netherlands is low (~60%) compared to other childhood vaccinations (>90%), and even lower among ethnic minorities. The aim of this study was to explore the possible impact of ethnicity on the determinants of both HPV vaccination intention and HPV vaccination uptake among parents/guardians having a daughter that is invited for the HPV vaccination.

    Methods: In February 2014, parents/guardians living in Amsterdam were invited to complete a questionnaire about social-psychological determinants of their decision making process regarding the HPV vaccination of their daughter and socio-demographic characteristics. Read More

    HIV-Infected Young Men Demonstrate Appropriate Risk Perceptions and Beliefs about Safer Sexual Behaviors after Human Papillomavirus Vaccination.
    AIDS Behav 2017 Feb 20. Epub 2017 Feb 20.
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
    The aim of this study was to identify risk perceptions after human papillomavirus (HPV) vaccination among HIV-infected young men who have sex with men. On average, participants appropriately perceived themselves to be at lower than neutral risk for HPV (mean subscale score 4.2/10), at higher than neutral risk for other sexually transmitted infections (7. Read More

    FKBP51 Immunohistochemical Expression: A New Prognostic Biomarker for OSCC?
    Int J Mol Sci 2017 Feb 18;18(2). Epub 2017 Feb 18.
    Department of Advanced Biomedical Sciences, University "Federico II", 80131 Naples, Italy.
    Up-to-date, several molecular markers of prognosis have been studied in Oral Squamous Cell Carcinoma (OSCC), but none entered in the clinical setting. Therapy of OSCC tumors mainly relies on surgery, radiotherapy and partially on chemotherapy; there is an urgent need for biomarkers able to better stratify OSCC patients' risk to address targeted therapeutic strategies. The role of immune response in the pathogenesis and biological behavior of OSCC has been investigated by several authors, and promising results have been obtained with immune checkpoint inhibitors. Read More

    Cytology of the neovagina in transgender women and individuals with congenital or acquired absence of a natural vagina.
    Cytopathology 2017 Feb 20. Epub 2017 Feb 20.
    Institute of Clinical Pathology, University Hospital Zurich, Zurich, Switzerland.
    Objective: The primary objective of this study was to describe the cytological findings of bowel and (penile) skin-lined neovaginas in patients with gender dysphoria (GD) and individuals with a congenital or acquired absence of a natural vagina. The secondary objective was to correlate the cytological findings with clinical characteristics such as oestrogen replacement therapy (ERT).

    Methods: A retrospective review of an institutional pathology archive over a 15-year-period was performed to identify cytological samples of neovaginal vaults. Read More

    Dendritic cells infected by Ad-sh-SOCS1 enhance cytokine-induced killer (CIK) cell immunotherapeutic efficacy in cervical cancer models.
    Cytotherapy 2017 Feb 15. Epub 2017 Feb 15.
    Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address:
    Background Aims: Cervical cancer constitutes a major problem in women's health worldwide, but the efficacy of the standard therapy is unsatisfactory. Cytokine-induced killer (CIK) cells exhibit antitumor activity against a variety of malignancies in preclinical models and have proven safe and effective in clinical trials. However, current CIK therapy has limitations and needs to be improved to meet the clinical requirements. Read More

    Impact of the Cancer Prevention and Control Research Network: Accelerating the Translation of Research Into Practice.
    Am J Prev Med 2017 Mar;52(3S3):S233-S240
    Department of Health Policy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
    The Cancer Prevention and Control Research Network (CPCRN) is a thematic network dedicated to accelerating the adoption of evidence-based cancer prevention and control practices in communities by advancing dissemination and implementation science. Funded by the Centers for Disease Control and Prevention and National Cancer Institute, CPCRN has operated at two levels: Each participating network center conducts research projects with primarily local partners as well as multicenter collaborative research projects with state and national partners. Through multicenter collaboration, thematic networks leverage the expertise, resources, and partnerships of participating centers to conduct research projects collectively that might not be feasible individually. Read More

    Racial disparities in preventable risk factors for head and neck cancer.
    Laryngoscope 2017 Feb 19. Epub 2017 Feb 19.
    Harvard University, Brigham and Women's Hospital, Boston, Massachusetts, U.S.A.
    Objectives/hypothesis: To demonstrate racial differences in preventable risk behaviors/practices that contribute to head and neck cancer (HNCA).

    Study Design: Cross-sectional analysis of large national risk factor survey.

    Methods: The Behavioral Risk Factor Surveillance System for 2013 was analyzed. Read More

    Synchronous carcinosarcoma of the uterine cervix with adenoid basal carcinoma and cervical intraepithelial neoplasia III: A case report and literature review.
    Pathol Res Pract 2017 Feb 7. Epub 2017 Feb 7.
    Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:
    Carcinosarcoma and adenoid basal carcinoma (ABC) are both rare lesions in uterine cervix. There were only 5 cases of cervical carcinosarcoma combined with ABC and/without cervical intraepithelial neoplasia (CIN) reported in English literature. These limited studies showed that there was a strong association between HPV, carcinosarcoma, ABC and CIN, suggesting a common etiology for these lesions. Read More

    Prevalence of human papillomavirus infection among 71,435 women in Jiangxi Province, China.
    J Infect Public Health 2017 Feb 14. Epub 2017 Feb 14.
    Department of Anesthesiology, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, People's Republic of China. Electronic address:
    Cervical cancer is the third most common cancer in women worldwide. Human papillomavirus (HPV) has been identified as an etiological factor for cervical cancer. Data on the prevalence and subtype distribution of HPV infection in Jiangxi Province are incomplete. Read More

    Disease burden of human papillomavirus infection in the Netherlands, 1989-2014: the gap between females and males is diminishing.
    Cancer Causes Control 2017 Feb 17. Epub 2017 Feb 17.
    Centre for Infectious Disease Control, National Institute for Public Health and the Environment, PO Box 1, 3720 BA, Bilthoven, The Netherlands.
    Purpose: Besides cervical cancer, HPV infection is linked to a multitude of diseases in both males and females, suggesting that vaccination programmes should be re-evaluated, with a judicious assessment made of the disease burden stratified by sex, age, and genotype. Projections of burden into the near future are also needed to provide a benchmark for evaluating the impact of vaccination programmes, and to assess the need for scaling-up preventive measures.

    Methods: Using the disability-adjusted life-years (DALY) measure, we estimated the total HPV-associated disease burden in the Netherlands. Read More

    Cytokeratin7 and cytokeratin19 expression in high grade cervical intraepithelial neoplasm and squamous cell carcinoma and their possible association in cervical carcinogenesis.
    Diagn Pathol 2017 Feb 17;12(1):18. Epub 2017 Feb 17.
    Department of Internal Medicine, Division of Infectious Diseases, Gachon University Gil Medical Center, 1198 Guwol-dong, Namdong-gu, Incheon, 405-760, Korea.
    Background: High risk human papillomavirus (HR HPV) infects cells at the squamocolumnar junction (SCJ) of the cervix, causing cancer. Cytokeratin (CK)7 is an SCJ marker, and stains cervical neoplasia. CK19 is a binding partner of CK7 and expressed in cervical cancer. Read More

    [Five-year survival analysis in patients with penile cancer].
    Rev Med Inst Mex Seguro Soc 2017 ;55 Suppl 1:S34-S43
    División de Investigación en Salud, Hospital de Traumatología y Ortopedia, Centro Médico Nacional "Manuel Ávila Camacho", Instituto Mexicano del Seguro Social, Puebla, Puebla, México.
    Background: Short-term survival of penile cancer is poor. The objective was to describe the 5-years penile cancer survival.

    Methods: Retrospective cohort study. Read More

    Cutaneous squamous cell carcinoma: an epidemiological review.
    Br J Dermatol 2017 Feb 16. Epub 2017 Feb 16.
    Cancer Control Group, QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital, QLD 4029, Brisbane, Australia.
    Cutaneous squamous cell carcinoma (SCC) is a common cancer in white populations and its disease burden is often substantially underestimated. SCC occurs more often in men than women and increases dramatically with age; those affected often develop multiple primaries over time, which increases the burden. The main external cause is solar ultraviolet radiation (UVR), with immunosuppression being the other established risk factor, shown by the high SCC rates in organ transplant recipients. Read More

    Human Papillomavirus (HPV) virion induced cancer and subfertility, two sides of the same coin.
    Facts Views Vis Obgyn 2016 Dec;8(4):211-222
    Department of Clinical and Molecular Pathology, AML, Sonic Healthcare, Antwerp, Belgium.
    In the natural history of HPV infections, the HPV virions can induce two different pathways, namely the infec- tious virion producing pathway and the clonal transforming pathway. An overview is given of the burden that is associated with HPV infections that can both lead to cervical cancer and/or temporal subfertility. That HPV infections cause serious global health burden due to HPV-associated cancers is common knowledge, but that it is also responsible for a substantial part of idiopathic subfertility is greatly underestimated. Read More

    Treatment of Carcinoma In Situ of the Glans Penis With Topical Imiquimod Followed by Carbon Dioxide Laser Excision.
    Clin Genitourin Cancer 2017 Jan 18. Epub 2017 Jan 18.
    Department of Urology, IRCCS Fondazione, Istituto Nazionale dei Tumori, Milan, Italy.
    Background: Different approaches have been described in published studies for carcinoma in situ (CIS) of the glans penis (erythroplasia of Queyrat), including topical chemotherapy or immunotherapy and laser or surgical excision. We evaluated the efficacy of topical imiquimod (IQ) followed by carbon dioxide laser ablation of the lesion.

    Patients And Methods: From 2010 to 2015, 10 patients affected by CIS of the glans were treated by IQ, followed by carbon dioxide laser ablation. Read More

    Splicing and Polyadenylation of Human Papillomavirus Type 16 mRNAs.
    Int J Mol Sci 2017 Feb 9;18(2). Epub 2017 Feb 9.
    Department of Laboratory Medicine, Lund university, 223 62 Lund, Sweden.
    The human papillomavirus type 16 (HPV16) life cycle can be divided into an early stage in which the HPV16 genomic DNA is replicated, and a late stage in which the HPV16 structural proteins are synthesized and virions are produced. A strong coupling between the viral life cycle and the differentiation state of the infected cell is highly characteristic of all HPVs. The switch from the HPV16 early gene expression program to the late requires a promoter switch, a polyadenylation signal switch and a shift in alternative splicing. Read More

    Mexican American College Men's (Mis)Understandings About HPV and Cervical Cancer.
    Fam Community Health 2017 Apr/Jun;40(2):150-159
    Independent Consultant, Orlando, Florida (Dr Schiffner); and University of Miami, Coral Gables, Florida (Dr Buki and Ms Sabet).
    Latinas have disproportionally high rates of cervical cancer in part due to their reliance on Latino partners to make sexual health decisions, their limited knowledge about human papillomavirus (HPV), and inconsistent Pap smear screening behaviors. In this qualitative study, we examined the sexual health beliefs of Latino college men regarding HPV. Participants included 6 Mexican American college students from a large Midwestern university. Read More

    Predictors of Human Papillomavirus Vaccine Initiation and Completion Among Latino Mothers of 11- to 17-Year-Old Daughters Living Along the Texas-Mexico Border.
    Fam Community Health 2017 Apr/Jun;40(2):139-149
    Latino Research Initiative, University of Texas at Austin.
    Few Texas Latino girls initiate and complete the human papillomavirus (HPV) vaccine series, but few studies have examined predictors of initiation and completion in this group. Mothers are crucial to vaccine uptake. Using self-reported data from mothers of unvaccinated girls (n = 317), we examined the association between predictors (HPV and HPV vaccine knowledge, vaccine self-efficacy) and outcomes (initiation and completion). Read More

    Comparison of AdvanSure HPV GenoBlot and Hybrid Capture 2 assays for detection of HPV infection.
    J Clin Lab Anal 2017 Feb 15. Epub 2017 Feb 15.
    Department of Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Background: We sought to compare the performance of the AdvanSure assay to the Hybrid Capture (HC) 2 for the detection of high-risk human papillomavirus (HR HPV).

    Methods: A total of 855 cervical swab specimens were obtained. We submitted all specimens for HR HPV detection with HC2 and the AdvanSure assay. Read More

    A review of screening strategies for cervical cancer in human immunodeficiency virus-positive women in sub-Saharan Africa.
    Int J Womens Health 2017 2;9:69-79. Epub 2017 Feb 2.
    Gynecology Division, Geneva University Hospitals, Geneva, Switzerland.
    Cervical cancer (CC) is a leading cause of cancer-related death and a major public health issue in sub-Saharan Africa. This heavy burden parallels that of the human immunodeficiency virus (HIV) infection, which increases the risk of developing CC. Despite the progressive reduction of HIV prevalence in the past decade, the CC incidence and mortality rates in sub-Saharan Africa remain high. Read More

    Low prevalence of human papillomavirus in head and neck squamous cell carcinoma in the northwest region of the Philippines.
    PLoS One 2017 15;12(2):e0172240. Epub 2017 Feb 15.
    Division of Molecular Diagnostics of Oncogenic Infections, Research Program Infection and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Background: Geographic heterogeneity of human papillomavirus (HPV) involvement in head and neck squamous cell carcinoma (HNSCC) has been observed over the last few years. This trend has not been evaluated in the Philippines. Hence, this study aims to provide for the first time a data on the prevalence of HPV in HNSCC in the northwestern region of the Philippines. Read More

    High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil.
    J Appl Oral Sci 2017 Jan-Feb;25(1):69-74
    Universidade Federal de Sergipe, Laboratório de Entomologia e Parasitologia Tropical, Departamento de Morfologia, São Cristóvão, SE, Brasil.
    Objective: The aim of this study was to evaluate the frequency of HPV infection and its genotypes in patients with oral lesions at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Brazil.

    Material And Methods: We conducted a molecular study with 21 patients (15 females) aged from two to 83 years with clinically detectable oral lesions. Samples were collected through exfoliation of lesions and HPV-DNA was identified using MY09/11 and GP5+/6+ primers. Read More

    FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication.
    MBio 2017 Feb 14;8(1). Epub 2017 Feb 14.
    Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    The life cycle of human papillomavirus (HPV) is dependent on the differentiation state of its host cell. HPV genomes are maintained as low-copy episomes in basal epithelial cells and amplified to thousands of copies per cell in differentiated layers. Replication of high-risk HPVs requires the activation of the ataxia telangiectasia-mutated (ATM) and ATM and Rad3-related (ATR) DNA repair pathways. Read More

    GTL001 and bivalent CyaA-based therapeutic vaccine strategies against human papillomavirus and other tumor-associated antigens induce effector and memory T-cell responses that inhibit tumor growth.
    Vaccine 2017 Feb 10. Epub 2017 Feb 10.
    Genticel, 5 rue Tronchet, 75008 Paris, France.
    GTL001 is a bivalent therapeutic vaccine containing human papillomavirus (HPV) 16 and HPV18 E7 proteins inserted in the Bordetella pertussis adenylate cyclase (CyaA) vector intended to prevent cervical cancer in HPV-infected women with normal cervical cytology or mild abnormalities. To be effective, therapeutic cervical cancer vaccines should induce both a T cell-mediated effector response against HPV-infected cells and a robust CD8(+) T-cell memory response to prevent potential later infection. We examined the ability of GTL001 and related bivalent CyaA-based vaccines to induce, in parallel, effector and memory CD8(+) T-cell responses to both vaccine antigens. Read More

    Mean direct medical care costs associated with cervical cancer for commercially insured patients in Texas.
    Gynecol Oncol 2017 Feb 10. Epub 2017 Feb 10.
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA. Electronic address:
    Objective: To determine the mean cervical cancer medical care costs for patients enrolled in commercial insurance in Texas. Cost is represented by insurer and patient payments for care.

    Methods: We estimated the mean medical care costs during the first 2years after the index diagnosis date for patients with cervical cancer (cases). Read More

    Re-evaluation of epidermodysplasia verruciformis: Reconciling more than 90 years of debate.
    J Am Acad Dermatol 2017 Feb 10. Epub 2017 Feb 10.
    Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem. Electronic address:
    Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by abnormal susceptibility to cutaneous human beta-papillomavirus infections causing persistent flat warts or pityriasis versicolor-like lesions. This generalized verrucous skin disorder resembles generalized verrucosis, but these 2 conditions are distinguished by differences in clinical manifestation and the human papillomavirus types involved. A breakthrough in our understanding of EV was the discovery that homozygous inactivating mutations in TMC6 (EVER1) and TMC8 (EVER2) determine susceptibility to this disorder; however, they have not solved all EV cases fully. Read More

    Association of Human Papillomavirus Vaccine With the Development of Keratinocyte Carcinomas.
    JAMA Dermatol 2017 Feb 8. Epub 2017 Feb 8.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida4Treasure Coast Dermatology, Port St Lucie, Florida.
    Importance: Keratinocyte carcinomas (KCs), consisting of squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs), are the most common human malignant neoplasms. Several risk factors have been implicated in KC development. For some SCCs, particularly those in immunocompromised patients, human papillomavirus (HPV) may be an important factor. Read More

    Notch1 Overexpression Correlates to Improved Survival in Cancer of the Oropharynx.
    Otolaryngol Head Neck Surg 2017 Feb 1:194599816688178. Epub 2017 Feb 1.
    1 Department of Otolaryngology, Division of Head and Neck Surgery and The James Cancer Hospital and Solove Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
    Objectives The Notch1 signaling pathway has recently been shown to be highly dysregulated in head and neck squamous cell carcinoma, but the value of Notch1 as a predictive biomarker is yet to be elucidated in oropharyngeal squamous cell carcinoma (OPSCC). The objective of this study is to evaluate Notch1 expression in surgical OPSCC specimens and determine clinicopathologic correlates. Study Design Case series with planned data collection. Read More

    Significant changes in sexual behavior after a diagnosis of human papillomavirus-positive and human papillomavirus-negative oral cancer.
    Cancer 2017 Feb 14. Epub 2017 Feb 14.
    Department of Medicine, The Ohio State University, Columbus, Ohio.
    Background: Sexual behavior and oral human papillomavirus (HPV) infection are risk factors for oral squamous cell carcinoma (OSCC). The effects of OSCC diagnosis and treatment on subsequent relationship stress and sexual behavior are unknown.

    Methods: Incident cases of HPV-positive or HPV-negative OSCC in patients who had a partnered relationship and partners of patients with oropharyngeal cancer were eligible for a study in which surveys were administered at diagnosis and at the 6-month follow-up time point to assess relationship distress, HPV transmission and concerns about health consequences, and sexual behavior. Read More

    Human papillomavirus self-sampling for screening non-attenders: Opt-in pilot implementation with electronic communication platforms.
    Int J Cancer 2017 Feb 13. Epub 2017 Feb 13.
    Department of Pathology, Copenhagen University Hospital, Hvidovre, Denmark.
    In organized cervical screening programs, typically 25% of the invited women do not attend. The Copenhagen Self-sampling Initiative (CSi) aimed to gain experiences on participation among screening non-attenders in the Capital Region of Denmark. Here, we report on the effectiveness of different communication platforms used in the pilot with suggestions for strategies prior to a full-implementation. Read More

    Diagnostic role of detecting HPV in a FNAC of metastatic laterocervical lymph node in a case of occult HPV-related head and neck squamous cell carcinoma.
    Pathologica 2016 Jun;108(2):87-88
    Cytopathology Unit, "Azienda Ospedaliera Universitaria Senese", Siena, Italy.
    Human papillomavirus (HPV)-related head and neck squamous cell carcinomas (HNSCC) are radiosensitive tumors and have a better prognosis than the conventional keratinizing HNSCC. Despite extensive radiographic and clinical evaluation in approximately 3% to 5% of patients who present with cervical lymph node metastases, the primary tumor remains occult. The lack of a clinically identifiable primary tumor usually leads to more aggressive therapy, which can result in higher morbidity. Read More

    Unsupervised exercise in survivors of human papillomavirus related head and neck cancer: how many can go it alone?
    J Cancer Surviv 2017 Feb 13. Epub 2017 Feb 13.
    Penn State College of Medicine, Hershey, PA, USA.
    Purpose: Patients with human papillomavirus (HPV)-related head and neck cancer (HNC) have a better prognosis relative to other types of HNC, making survivorship an emerging and critical issue. Exercise is a core component of survivorship care, but little is known about how many survivors of HPV-related HNC can safely be advised to start exercising on their own, as opposed to needing further evaluation or supervised exercise.

    Methods: We utilized guidelines to identify health issues that would indicate value of further evaluation prior to being safely prescribed unsupervised exercise. Read More

    Evolutionary and functional implications of hypervariable loci within the skin virome.
    PeerJ 2017 7;5:e2959. Epub 2017 Feb 7.
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA; Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA.
    Localized genomic variability is crucial for the ongoing conflicts between infectious microbes and their hosts. An understanding of evolutionary and adaptive patterns associated with genomic variability will help guide development of vaccines and antimicrobial agents. While most analyses of the human microbiome have focused on taxonomic classification and gene annotation, we investigated genomic variation of skin-associated viral communities. Read More

    Quality of life of young patients with recurrent respiratory papillomatosis.
    J Laryngol Otol 2017 Feb 14:1-4. Epub 2017 Feb 14.
    Medical Research Unit in Otoneurology,Centro Médico Nacional SXXI,Instituto Mexicano del Seguro Social,Mexico City,Mexico.
    Objective: To assess quality of life of children and teenagers with recurrent respiratory papillomatosis, according to the evidence of infection by human papillomavirus types 6 and 11, compared with healthy volunteers and patients with chronic otitis media.

    Method: Participants and their parents completed the Pediatric Quality of Life Inventory 4.0. Read More

    Factors associated with parental reasons for "no-intent" to vaccinate female adolescents with human papillomavirus vaccine: National Immunization Survey - Teen 2008-2012.
    BMC Pediatr 2017 Feb 13;17(1):52. Epub 2017 Feb 13.
    Department of Biostatistics, Environmental Health Sciences, and Epidemiology, College of Public Health, Kent State University, Hilltop Drive, 320 Lowry Hall, Kent, 44242, OH, USA.
    Background: 1) To identify socio-demographic factors associated with parental "no-intent" for their 13-17 year old unvaccinated daughter to receive the human papillomavirus (HPV) vaccine series within the next twelve months, 2) to describe patterns in "no-intent" by socio-demographic factors, and 3) to identify socio-demographic factors associated with parental reasons for "no-intent".

    Methods: Data from 2008-2012 National Immunization Survey - Teen (NIS - Teen) were examined in this study. Parents with "no-intent" to vaccinate their daughters were asked to identify reasons for their decision. Read More

    Perceptions of HPV and attitudes towards HPV vaccination amongst men who have sex with men: A qualitative analysis.
    Br J Health Psychol 2017 Feb 13. Epub 2017 Feb 13.
    Brighton and Sussex Medical School, UK.
    Objectives: Men who have sex with men (MSM) are at risk of genital warts and anal cancer due to human papillomavirus (HPV) infection. This study explores MSMs' perceptions of HPV and HPV vaccination prior to the introduction of this programme.

    Design: Focus groups and one-to-one interviews with self-identified MSM were conducted between November 2014 and March 2015 in Brighton, UK. Read More

    Presence of cutaneous human papillomavirus DNA in squamous cell carcinoma of the scalp: a case series.
    J Eur Acad Dermatol Venereol 2017 Feb 13. Epub 2017 Feb 13.
    Dermatology Division, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
    Various hypotheses have been put forward on the pathogenesis of squamous cell carcinoma (SCC), including chronic sun damage and exposure to ultraviolet radiation (UVR), chemicals, smoking, immunosuppressive medications and human papillomavirus (HPV)(1) . It is well known that alpha (mucosal) HPV types, in particular HPV-16 and HPV-18, are etiologically correlated to cervical cancer and other types of anogenital carcinoma and oropharyngeal papillomatosis(1) . On the contrary, the pathogenesis of squamous cell carcinoma (SCC) outside the mucosae remains obscure, and the link with HPVs has been demonstrated only in the epidermodysplasia verruciformis context(2-3) . Read More

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