45,375 results match your criteria Human Papillomavirus


Human Papillomavirus Infection in Senegalese Female Sex Workers.

Papillomavirus Res 2019 Feb 13. Epub 2019 Feb 13.

Bacteriology-Virology Laboratory, CHU Aristide le Dantec, Dakar, Senegal.

Objectives: Several studies have documented the HPV genotypes in the Senegalese general population. The objective was to explore the HPV genotype distribution in Senegalese FSWs in order to assess the potential relevance of currently-available vaccines.

Methods: Vaginal swabs samples collected as part of the National Integrated Biological and Behavioral Survey in 14 regions throughout the country were randomly selected for HPV testing using bead-based multiplex genotyping (TS-MPG). Read More

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http://dx.doi.org/10.1016/j.pvr.2019.02.003DOI Listing
February 2019

Postoperative Treatment of Oropharyngeal Cancer in the Era of Human Papillomavirus.

Curr Treat Options Oncol 2019 Feb 15;20(3):20. Epub 2019 Feb 15.

Department of Head and Neck Oncologic Surgery, Head and Neck Institute, Cleveland Clinic, 9500 Euclid Avenue, A-71, Cleveland, OH, 44195, USA.

Opinion Statement: Despite an overall decline in the incidence of tobacco-related cancers, human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) of the oropharynx is on the rise. The prognosis of HPV-related oropharynx cancer (HPV-OPC) is generally favorable even in locoregionally advanced disease, and a variety of treatment options are available. Though the primary treatment modality of choice remains definitive radiation (RT), surgical resection followed by appropriate adjuvant therapy remains an option, especially in those patients who may not be favorable candidates for definitive radiotherapy, particularly when concurrent chemotherapy is warranted. Read More

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http://dx.doi.org/10.1007/s11864-019-0620-yDOI Listing
February 2019

High-risk human papilloma virus testing improves diagnostic performance to predict moderate-to-high grade anal intraepithelial neoplasia in HIV-infected men who have sex with men in low-to-absent cytological abnormalities.

Clin Infect Dis 2019 Feb 16. Epub 2019 Feb 16.

Unidad Clínica de Enfermedades Infecciosas y Medicina Preventiva (UCEIMP). Hospital Universitario Virgen del Rocío. Seville, Spain.

Background: Screening methods for anal intraepithelial neoplasia (AIN) are suboptimal. This study aimed to determine the diagnostic performance of a composite endpoint comprising anal liquid-based cytology (aLBC) and high-risk human papillomavirus (HR-HPV) testing to predict histological high-grade squamous intraepithelial lesions (HSIL).

Methods: From a cohort of HIV-infected men who have sex with men (MSM) seen at a Spanish University hospital, all individuals who had an aLBC with concomitant HR-HPV testing were included. Read More

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http://dx.doi.org/10.1093/cid/ciz144DOI Listing
February 2019

Toward a Model of HPV Vaccine Series Completion in Adolescent Hispanic Males: Identifying Mothers' Salient Behavioral, Normative, and Control Beliefs.

Fam Community Health 2019 Apr/Jun;42(2):161-169

Department of Social Sciences, University of Houston-Downtown, Texas (Dr Roncancio); Psychological Health and Learning Sciences, University of Houston, Texas (Dr Carmack); Texas Oncology, Sugar Land (Dr Ward); Center for Health Promotion and Prevention Research, The University of Texas School of Public Health, Houston (Dr Vernon and Ms Cribbs); Department of Psychology, Mount St Mary's University, Emmitsburg, Maryland (Dr Muñoz); and Department of Epidemiology, Florida International University, Miami (Dr Cano).

Human papillomavirus (HPV) vaccine series completion among adolescent Hispanic males (35%) is lower than the Healthy People 2020 80% goal. This directed qualitative content analysis identified mothers' beliefs about their sons completing the series. We found that mothers (N = 19) (1) express positive feelings; (2) believe the vaccine has positive effects; (3) identify the father and doctors as supporters and friends as nonsupporters; (4) list health insurance, transportation, and clinic reminders as facilitators; and (5) mention affordability as a barrier to vaccine completion. Read More

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http://dx.doi.org/10.1097/FCH.0000000000000221DOI Listing
February 2019

Does Male Circumcision Reduce Women's Risk of Sexually Transmitted Infections, Cervical Cancer, and Associated Conditions?

Front Public Health 2019 31;7. Epub 2019 Jan 31.

Department of Urology, University of Washington School of Medicine, Seattle, WA, United States.

Male circumcision (MC) is proven to substantially reduce men's risk of a number of sexually transmitted infections (STIs). We conducted a detailed systematic review of the scientific literature to determine the relationship between MC and risk of STIs and associated conditions in women. Database searches by "circumcision women" and "circumcision female" identified 68 relevant articles for inclusion. Read More

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http://dx.doi.org/10.3389/fpubh.2019.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365441PMC
January 2019

Positivity Rates in Oropharyngeal and Nonoropharyngeal Head and Neck Cancer in the VA.

Fed Pract 2018 Aug;35(Suppl 5):S44-S47

and are Attending Physicians; is the Section Chief of the Hematology/Oncology Division; and is the Section Chief of Radiation Oncology, all at Kansas City VAMC in Missouri. is a Nurse Practitioner, and is an Attending Physician, both at the VA Eastern Kansas Health Care System Topeka campus. Dr. Park is a Clinical Assistant Professor, and Dr. Reddy is a Clinical Professor, both in the Department of Radiology at the University of Missouri, Kansas City. Dr. Huang and Dr. Kambhampati are Associate Professors, Medical Oncology at the University of Kansas School of Medicine in Kansas City.

The rates of human papillomavirus positivity of the p16 biomarker in veterans were similar to those of patients with oropharyngeal head and neck tumors in the general population, but differed from general population patients with nonoropharyngeal squamous cell carcinoma. Read More

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Imaging Review of New and Emerging Sinonasal Tumors and Tumor-like Entities from the Fourth Edition of the .

AJNR Am J Neuroradiol 2019 Feb 14. Epub 2019 Feb 14.

From the Department of Radiology (K.E.D., C.D.P.), NewYork-Presbyterian/Weill Cornell Medical Center, New York, New York.

The sinonasal tract is an environment diverse with neoplasia. Given the continued discovery of entities generally specific to the sinonasal tract, the fourth edition of the was released in 2017. It describes 3 new, well-defined entities and several less-defined, emerging entities. Read More

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http://dx.doi.org/10.3174/ajnr.A5978DOI Listing
February 2019

Effect of Tumor Size and p16 Status on Treatment Outcomes - Achievement of Complete Remission in Prospectively Followed Patients with Oropharyngeal Tumors.

Klin Onkol 2019 ;32(1):58-65

Background: Oropharyngeal squamous cell tumors associated with human papillomavirus infection (p16 positive tumors) have better prognosis than p16 negative tumors regardless of the more advanced stage of the disease. Tumor volume (GTVt+n) is generally an important factor affecting treatment results of ionizing radiation. The aim of this prospective non-randomized study is to evaluate the effect of tumor volume on the (chemo)radiation treatment results in a group of patients with p16 negative and p16 positive oropharyngeal tumors. Read More

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January 2019
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Malignant Tumors of the Penis - Dia-gnostics and Therapy.

Klin Onkol 2019 ;32(1):31-39

Background: Penile cancer belongs to group of relatively rare malignancies. It represents, on average, 0.5-1% of all tumours in males globally and occurs predominantly in older individuals (> 65 years). Read More

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http://dx.doi.org/10.14735/amko201931DOI Listing
January 2019

Vaccination against HPV and view of new possibilities.

Ceska Gynekol 2018 ;83(3):218-225

Objective: Overview of available information on current vaccination options against HPV and possibilities for further development.

Design: Review article.

Settings: Clinic of Gynecology and Obstetrics, University Hospital in Ostrava; Clinic of Gynecology and Obstetrics, General University Hospital in Prague. Read More

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January 2018
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Reprogramming of Energy Metabolism in Response to Radiotherapy in Head and Neck Squamous Cell Carcinoma.

Cancers (Basel) 2019 Feb 5;11(2). Epub 2019 Feb 5.

Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología, México/Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, San Fernando No. 22, Col. Sección XVI, Tlalpan, Ciudad de México 14080, México.

Head and neck cancer (HNC) is the sixth cause of cancer-related death worldwide. Head and neck squamous cells carcinoma (HNSCC) is the most frequent subtype of HNC. The development of HNSCC is associated to alcohol consumption, smoking or infection by high-risk human Papillomavirus (HR-HPV). Read More

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http://dx.doi.org/10.3390/cancers11020182DOI Listing
February 2019

The association between human papillomavirus infection and head and neck cancer: A population-based cohort study.

Medicine (Baltimore) 2019 Feb;98(7):e14436

School of Medicine, Chung Shan Medical University.

Human papillomavirus (HPV) has been linked with development of oropharyngeal squamous cell carcinoma, a subset of head and neck cancer (HNC). This study aimed to evaluate the association between HPV infection and subsequent development of HNC and to report epidemiological information in Taiwan.This population-based cohort study retrieved patient data from the longitudinal health insurance database (LHID) of Taiwan's National Health Insurance Research Database (NHIRD) from 2005 to 2010 and analyzed it retrospectively. Read More

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http://dx.doi.org/10.1097/MD.0000000000014436DOI Listing
February 2019

A first case of primary gastric verrucous carcinoma with isolated squamous epithelium in the stomach.

Virchows Arch 2019 Feb 13. Epub 2019 Feb 13.

Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.

Primary gastric squamous cell carcinoma (SCC) is a rare histological subtype of gastric cancer. Here, we report the first case of primary gastric verrucous carcinoma (VC), a well-differentiated variant of SCC. Gastroscopy revealed a papillary polypoid lesion at the posterior wall of the upper gastric body and isolated squamous epithelium at the greater curvature of the fornix in a 78-year-old woman. Read More

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http://link.springer.com/10.1007/s00428-019-02542-8
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http://dx.doi.org/10.1007/s00428-019-02542-8DOI Listing
February 2019
1 Read

Risk Factors and Clinical Outcomes of Head and Neck Cancer in Inflammatory Bowel Disease: A Nationwide Cohort Study.

Inflamm Bowel Dis 2018 Aug;24(9):2015-2026

Inflammatory Bowel Disease Centre, Department of Gastroenterology and Hepatology.

Background: Immunosuppressed inflammatory bowel disease (IBD) patients are at increased risk to develop extra-intestinal malignancies. Immunosuppressed transplant patients show increased incidence of head and neck cancer with impaired survival. This study aims to identify risk factors for oral cavity (OCC) and pharyngeal carcinoma (PC) development in IBD, to compare clinical characteristics in IBD with the general population, and to assess the influence of immunosuppressive medication on survival. Read More

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https://academic.oup.com/ibdjournal/article/24/9/2015/499994
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http://dx.doi.org/10.1093/ibd/izy096DOI Listing
August 2018
1 Read

Repression of Human Papillomavirus Oncogene Expression under Hypoxia Is Mediated by PI3K/mTORC2/AKT Signaling.

MBio 2019 Feb 12;10(1). Epub 2019 Feb 12.

Molecular Therapy of Virus-Associated Cancers, German Cancer Research Center (DKFZ), Heidelberg, Germany

Hypoxia is linked to therapeutic resistance and poor clinical prognosis for many tumor entities, including human papillomavirus (HPV)-positive cancers. Notably, HPV-positive cancer cells can induce a dormant state under hypoxia, characterized by a reversible growth arrest and strong repression of viral E6/E7 oncogene expression, which could contribute to therapy resistance, immune evasion and tumor recurrence. The present work aimed to gain mechanistic insights into the pathway(s) underlying HPV oncogene repression under hypoxia. Read More

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http://dx.doi.org/10.1128/mBio.02323-18DOI Listing
February 2019

Combined Aurora kinase A (AURKA) and WEE1 inhibition demonstrates synergistic antitumor effect in squamous cell carcinoma of the head and neck.

Clin Cancer Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine and Yale Cancer Center, Yale University School of Medicine

Purpose: Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC) commonly bear disruptive mutations in TP53, resulting in treatment resistance. In these patients, direct targeting of p53 has not been successful, but synthetic lethal approaches have promise. Although Aurora A kinase (AURKA) is overexpressed and an oncogenic driver, its inhibition has only modest clinical effects in HPV-negative HNSCC. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-0440DOI Listing
February 2019
2 Reads

Significance of serum antibodies against HPV E7, Hsp27, Hsp20 and Hp91 in Iranian HPV-exposed women.

BMC Infect Dis 2019 Feb 12;19(1):142. Epub 2019 Feb 12.

Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.

Background: Among different types of human papillomavirus (HPV), types 16 and 18 were known to be high-risk agents causing mainly cervical cancer. Up to now, the potential of HPV E7 protein has been proved as a diagnostic marker of cervical cancer. Moreover, the levels of anti-heat shock protein (Hsp) and anti-high mobility group box-1 (HMGB1) antibodies in cancer patients have been useful in tumor diagnosis. Read More

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http://dx.doi.org/10.1186/s12879-019-3780-2DOI Listing
February 2019

Salvage of Recurrence after Surgery and Adjuvant Therapy: A Multi-institutional Study.

Otolaryngol Head Neck Surg 2019 Feb 12:194599819830664. Epub 2019 Feb 12.

9 Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, Saint Louis, Missouri, USA.

Objectives: To determine the oncologic outcomes of patients undergoing salvage surgery for recurrent oral cavity squamous cell carcinoma (OCSCC) and oropharyngeal squamous cell carcinoma (OPSCC) after initial treatment with surgery and adjuvant therapy.

Study Design: Retrospective case series with chart review.

Setting: Five academic tertiary care centers. Read More

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http://dx.doi.org/10.1177/0194599819830664DOI Listing
February 2019
1.721 Impact Factor

Human Papillomavirus Risk Perceptions Among Young Adult Sexual Minority Cisgender Women and Nonbinary Individuals Assigned Female at Birth.

Perspect Sex Reprod Health 2019 Feb 12. Epub 2019 Feb 12.

Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston.

Context: Some sexual minority women may be less likely than other women to engage in human papillomavirus (HPV) prevention behaviors. Although risk perceptions have been found to be associated with health behaviors, HPV risk perceptions among U.S. Read More

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http://dx.doi.org/10.1363/psrh.12087DOI Listing
February 2019

The distribution and prevalence of human papillomavirus in women in mainland China.

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.

We conducted a systematic review of the epidemiology of high-risk human papillomavirus (HPV) infections in mainland Chinese women to provide a general profile for the application and subsequent effectiveness evaluation of HPV vaccines. The PubMed, Web of Science, Medline (Ovid), China National Knowledge Infrastructure, and Wanfang databases were used for the literature search. The epidemiological studies published from January 2000 to June 2018 on high-risk HPVs in mainland Chinese women were investigated to systematically evaluate their epidemiological status. Read More

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http://doi.wiley.com/10.1002/cncr.32003
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http://dx.doi.org/10.1002/cncr.32003DOI Listing
February 2019
2 Reads

HPV Vaccine in Adolescents.

Pediatr Ann 2019 Feb;48(2):e71-e77

Human papillomavirus (HPV), the most common sexually transmitted viral infection worldwide, is the causative agent for cervical cancer and attributed to anogenital cancers as well as oropharyngeal cancer. Three effective, safe, prophylactic HPV vaccines have been licensed, and studies have demonstrated decreases in HPV prevalence and HPV-related disease endpoints without evidence of waning protection to date. In the United States, only the 9-valent vaccine, which covers 90% of the cancers attributed to HPV in US registries, is available. Read More

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http://dx.doi.org/10.3928/19382359-20190118-02DOI Listing
February 2019
1 Read

HPV as a marker for molecular characterization in head and neck oncology: Looking for a standardization of clinical use and of detection method(s) in clinical practice.

Head Neck 2019 Feb 12. Epub 2019 Feb 12.

Infections and Cancer Biology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.

Background: A consensus about the most appropriate diagnostic method(s) for head and neck human papillomavirus (HPV)-induced carcinogenesis is still lacking because most of the commercially available assays have been designed for the cervix.

Methods: This article summarizes current data and trends concerning HPV diagnostic strategies in oropharyngeal squamous cell carcinoma (OPSCC). Six main approaches are described. Read More

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http://dx.doi.org/10.1002/hed.25591DOI Listing
February 2019

Inhibition of Heme Oxygenase-1 enhances hyperthermia-induced autophagy and antiviral effect.

Int J Biol Sci 2019 1;15(3):568-578. Epub 2019 Jan 1.

Key Laboratory of Medical Cell Biology, China Medical University, Shenyang, 110122, China.

Hyperthermia has been clinically utilized as an adjuvant therapy in the treatment of cervical carcinoma. However, thermotolerance induced by heme oxygenase-1 (HO-1), a stress-inducible cytoprotective protein, limits the efficacy of hyperthermic therapy, for which the exact mechanism remains unknown. In the present study, we found that heat treatment induced HO-1 expression and decreased copy number of HPV16 in cervical cancer cells and tissues from cervical cancer and precursor lesions. Read More

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http://dx.doi.org/10.7150/ijbs.29759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367586PMC
January 2019
1 Read

Hand-to-genital and genital-to-genital transmission of human papillomaviruses between male and female sexual partners (HITCH): a prospective cohort study.

Lancet Infect Dis 2019 Feb 8. Epub 2019 Feb 8.

Division of Cancer Epidemiology, Department of Oncology, McGill University, Montreal, QC, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada.

Background: Hand-to-genital contact is hypothesised to be a transmission mode of human papillomavirus (HPV) of the Alphapapillomavirus genus. We compared the relative importance of hand-to-genital and genital-to-genital HPV transmission between sexual partners.

Methods: In this prospective cohort study, we recruited and followed up female university students aged 18-24 years and their male sexual partners in Montreal, QC, Canada (2005-11). Read More

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http://dx.doi.org/10.1016/S1473-3099(18)30655-8DOI Listing
February 2019
1 Read

Some clear answers regarding transmission of genital human papillomavirus.

Authors:
Joakim Dillner

Lancet Infect Dis 2019 Feb 8. Epub 2019 Feb 8.

Laboratory of Medicine, Karolinska Institutet, 17177 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(19)30048-9DOI Listing
February 2019

Prevalence of human papillomavirus infection of 65,613 women in East China.

BMC Public Health 2019 Feb 11;19(1):178. Epub 2019 Feb 11.

Laboratory of gene amplification, Kingmed Diagnostics, Nanjing, 210043, China.

Background: The infection with human papillomavirus (HPV) is the major cause of genital disease. This study assessed the prevalence and genotype of HPV among outpatient women and healthy women in Jiangsu, East China.

Methods: A total of 65,613 women aged 16-85 years were recruited from Nanjing Kingmed Diagnostics, including 45,736 outpatients and 19,877 healthy women. Read More

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https://bmcpublichealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12889-019-6487-9DOI Listing
February 2019
3 Reads

Role of polycyclic aromatic hydrocarbons as a co-factor in human papillomavirus-mediated carcinogenesis.

BMC Cancer 2019 Feb 11;19(1):138. Epub 2019 Feb 11.

Departments of Microbiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.

Background: Human papillomavirus (HPV) is an etiological agent of cervical cancer. Yet co-factors are believed to be involved in HPV-mediated carcinogenesis. Polycyclic aromatic hydrocarbons (PAHs) are considered as one of these co-factors. Read More

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http://dx.doi.org/10.1186/s12885-019-5347-4DOI Listing
February 2019
1 Read
3.362 Impact Factor

Loss of CD169 Subcapsular Macrophages during Metastatic Spread of Head and Neck Squamous Cell Carcinoma.

Otolaryngol Head Neck Surg 2019 Feb 12:194599819829741. Epub 2019 Feb 12.

1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Objective: The purpose of this study is to assess CD169 expression in metastatic and nearby tumor-free lymph nodes of patients with head and neck squamous cell carcinoma (SCC).

Study Design: Retrospective analysis based on immunohistochemistry.

Setting: Tertiary care center. Read More

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http://dx.doi.org/10.1177/0194599819829741DOI Listing
February 2019

[Rush poppers use and risks of human papillomavirus infection among men who have sex with men in Urumqi: mediation effect through high-risk sexual behaviors].

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Feb;53(2):202-205

Department of Epidemiology and Health Statistics, College of Public Health, Xinjiang Medica, Urumqi 830011, China.

To study the prevalence of rush poppers use among men who have sex with men (MSM) in Urumqi and to analyze the mediating effect of high-risk sexual behavior between the use of rush poppers and human papillomavirus (HPV) infection. From January to June 2018, 651 MSM were recruited through network and publicity. Data was collected by using online questionnaire and anal swab were collected from them for HPV genotyping. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.02.015DOI Listing
February 2019
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Prevention and treatment of cervical cancer by a single administration of human papillomavirus peptide vaccine with CpG oligodeoxynucleotides as an adjuvant in vivo.

Int Immunopharmacol 2019 Feb 8;69:279-288. Epub 2019 Feb 8.

Department of Microbiology and Parasitology, College of Basic Medical Sciences, China Medical University, Shenyang, China. Electronic address:

No licensed therapeutic human papillomavirus (HPV) vaccine is currently available, so it remains a high priority to develop a therapeutic HPV vaccine or prophylactic/therapeutic HPV vaccine for cervical cancer. In this current study, we designed an HPV vaccine including CpG oligodeoxynucleotides 1826 as an adjuvant and HPV16 E7 43-77 peptide as antigen, which contains a CD8 T cell epitope (E7 49-57), and two CD4 T cell epitopes (E7 43-77 and E7 50-62). The prophylactic and therapeutic effect on cervical cancer induced by a single administration of vaccine, were comprehensively evaluated by examining the tumor size and the percentage of tumor-free/bearing mice. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.024DOI Listing
February 2019
1 Read

Low-Cost Instructional Apparatus to Improve Training for Cervical Cancer Screening and Prevention.

Obstet Gynecol 2019 Feb 4. Epub 2019 Feb 4.

Rice University, and the University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Cervical cancer remains one of the leading causes of cancer for women in medically underserved areas. This is in part due to a lack of trained clinicians to provide the necessary diagnosis and treatment of precancerous lesions to prevent cervical cancer. Increasing medical provider knowledge and skills is important for the early detection and prevention of cervical precancer and cancer in medically underserved areas of the United States and globally. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003140DOI Listing
February 2019
2 Reads

Clinical guideline for 9-valent HPV vaccine: Korean Society of Gynecologic Oncology Guideline.

J Gynecol Oncol 2019 Jan 9. Epub 2019 Jan 9.

Department of Obstetrics and Gynecology, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea.

In 2016, 9-valent human papillomavirus (HPV) vaccine has been newly introduced in Korea, thus the need to develop recommendations for the vaccine has raised. Until we decide to develop a guideline, no further studies on the bi-valent or quadri-valent HPV vaccine have been announced. We searched and reviewed the literatures focused on the efficacy of 9-valent HPV vaccine, the ideal age of 3-dose schedule vaccination, the efficacy of 9-valent HPV vaccine in middle-aged women, the efficacy of the 2-dose schedule vaccination, the safety of 9-valent HPV vaccine, the possibility of additional 9-valent HPV vaccination, and cross-vaccination of 9-valent HPV vaccine. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e31DOI Listing
January 2019

Cost effectiveness analysis of HPV primary screening and dual stain cytology triage compared with cervical cytology.

J Gynecol Oncol 2018 Nov 8. Epub 2018 Nov 8.

Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Objectives: To assess the clinical and cost-effectiveness of human papillomavirus (HPV) primary screening triage with p16/Ki-67 dual stain cytology compared to cytology.

Methods: We conducted an Excel®-based budget impact model to estimate the preinvasive and invasive cervical cancer cases identified, mortality rate, direct medical costs, quality-adjusted life years (QALYs) and the incremental cost-effectiveness analysis of two strategies from the healthcare payer perspective. The study population is a cohort of women 30-65 years of age presenting for cervical screening. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e17DOI Listing
November 2018
1 Read

Association between human papillomavirus infection and prostate cancer: A global systematic review and meta-analysis.

Asia Pac J Clin Oncol 2019 Feb 10. Epub 2019 Feb 10.

Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Although an increasing number of studies have been conducted to evaluate the association between human papillomavirus (HPV) infections and distribution of HPV types worldwide with the risk of prostate cancer (PC), the results remain inadequate. Hence, we investigated the association between HPV infection and PC risk using a meta-analysis. Relevant studies from January 1990 to December 2016 were searched in PubMed, Web of sciences, and Scopus databases. Read More

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http://dx.doi.org/10.1111/ajco.13124DOI Listing
February 2019

Detection of adenovirus, papillomavirus and parvovirus in Brazilian bats of the species Artibeus lituratus and Sturnira lilium.

Arch Virol 2019 Feb 10. Epub 2019 Feb 10.

Instituto Pasteur, Secretaria da Saúde do Governo do estado de São Paulo, Avenida Paulista, 393, Bairro Cerqueira César, São Paulo, São Paulo, 01311-000, Brazil.

Bats play a significant role in maintaining their ecosystems through pollination, dispersal of seeds, and control of insect populations, but they are also known to host many microorganisms and have been described as natural reservoirs for viruses with zoonotic potential. The diversity of viruses in these animals remains largely unknown, however, because studies are limited by species, location, virus target, or sample type. Therefore, the aim of this study was to detect fragments of viral genomes in bat samples. Read More

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http://dx.doi.org/10.1007/s00705-018-04129-1DOI Listing
February 2019

Epidermodysplasia verruciformis in a young adult with activated PI3Kδ syndrome.

JAAD Case Rep 2019 Feb 31;5(2):195-197. Epub 2019 Jan 31.

Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.1016/j.jdcr.2018.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357544PMC
February 2019

Post-hoc analysis from phase iii trials of human papillomavirus vaccines: considerations on impact on non-vaccine types.

Expert Rev Vaccines 2019 Feb 11. Epub 2019 Feb 11.

c GSK , Rixensart , Belgium.

Background: Substantial heterogeneity has been reported in efficacy against high-grade cervical intraepithelial neoplasia (CIN) irrespective of type in phase III results for bivalent and quadrivalent human papillomavirus virus (HPV) vaccines (AS04-HPV and qHPV). Real-world data recently confirmed very high overall impact of AS04-HPV, supporting the validity of the observed heterogeneity. To explore the reasons for heterogeneous efficacy, we assessed vaccine impact on high-grade lesions not caused by vaccine types. Read More

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http://dx.doi.org/10.1080/14760584.2019.1579647DOI Listing
February 2019
1 Read

Evaluation of p16/Ki-67 dual staining in the detection of cervical precancer and cancer in China.

Cancer Epidemiol 2019 Feb 7;59:123-128. Epub 2019 Feb 7.

Department of Cancer Epidemiology, Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450008, China. Electronic address:

Background This study aimed to evaluate the clinical performance of p16/Ki-67 dual staining in the detection of cervical intraepithelial neoplasia grade 2 or 3 or worse (CIN2+/CIN3+) in Chinese women. Methods Cervical exfoliated cells were collected from 537 eligible women and were used for liquid-based cytology (LBC), p16/Ki-67 dual staining, and human papillomavirus (HPV) DNA testing. All women received colposcopy with biopsies taken at abnormal sites. Read More

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http://dx.doi.org/10.1016/j.canep.2018.12.013DOI Listing
February 2019
2 Reads

Human papillomavirus DNA detection-guided ALA-photodynamic therapy for anogenital condyloma acuminata: a report of two cases.

Photodiagnosis Photodyn Ther 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

5-aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) is a highly effective, safe, and promising treatment for human papillomavirus (HPV)-induced anogenital condyloma acuminata (CA). Specific HPV subtypes are responsible for the pathogenesis of CA and dynamic changes in viral loads may reflect the efficiency of PDT. Here we present two cases of anogenital CA successfully treated by ALA-PDT under the guidance of HPV DNA detection including genotype identification and viral load measurement, which provided clues for unexpected intra-anal infection. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.003DOI Listing
February 2019
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Human papillomavirus 16 sub-lineage dispersal and cervical cancer risk worldwide: Whole viral genome sequences from 7116 HPV16-positive women.

Papillomavirus Res 2019 Feb 6;7:67-74. Epub 2019 Feb 6.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA. Electronic address:

Background: Human papillomavirus (HPV)16 can be separated into genetic sub-lineages (A1-4, B1-4, C1-4, D1-4) which may have differential cervical cancer risk.

Methods: A next-generation sequencing assay was used to whole-genome sequence 7116 HPV16-positive cervical samples from well-characterised international epidemiological studies, including 2076 controls, 1878 squamous cell carcinoma (SCC) and 186 adenocarcinoma/adenosquamous cell carcinoma (ADC), and to assign HPV16 sub-lineage. Logistic regression was used to estimate region-stratified country-adjusted odds ratios (OR) and 95%CI. Read More

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http://dx.doi.org/10.1016/j.pvr.2019.02.001DOI Listing
February 2019
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Examining adjuvant radiation dose in head and neck squamous cell carcinoma.

Head Neck 2019 Feb 9. Epub 2019 Feb 9.

Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

Background: Compare adjuvant radiation dose trends and outcomes in head and neck squamous cell carcinoma (HNSCC).

Methods: Nonmetastatic HNSCCs treated between 2004 and 2014 with primary site surgery, lymph node dissection, and adjuvant radiation were identified in the National Cancer Database. Standard dose radiation (SD-RT) was defined as an equivalent dose in 2 Gy (EQD2) ≥56. Read More

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http://dx.doi.org/10.1002/hed.25680DOI Listing
February 2019
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Genotype distribution and prevalence of human papillomavirus among women with cervical cytological abnormalities in Xinjiang, China.

Hum Vaccin Immunother 2019 Feb 8. Epub 2019 Feb 8.

a Department of Gynecology , First Affiliated Hospital of Xinjiang Medical University , Urumqi , Xinjiang , China.

Background: Genotype distribution and prevalence of human papillomavirus (HPV) among women vary from different regions and crowds, prophylactic HPV vaccin could prevent some diseases related to HPV, which include cervical precancerous lesions and cancer. Baseline surveys prior to mass HPV vaccination are critical to determine vaccine efficacy and detect changes in HPV type after vaccination.

Objective: The aim of this study is to study the HPV type-specific prevalence in 698 women with cytological abnormalities, aging from 18 to 77 years old. Read More

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http://dx.doi.org/10.1080/21645515.2019.1578598DOI Listing
February 2019
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Dental opinion leaders' perspectives on barriers and facilitators to HPV-related prevention.

Hum Vaccin Immunother 2019 Feb 8. Epub 2019 Feb 8.

a College of Public Health , University of South Florida , Tampa , FL , USA.

Evidence suggests a causal connection between the Human Papillomavirus (HPV) and oropharyngeal cancers. HPV-related oropharyngeal cancers are increasing and are the most common HPV-associated cancer. Previous research suggests that dental professionals recognize a role in the prevention of HPV and oropharyngeal cancers. Read More

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http://dx.doi.org/10.1080/21645515.2019.1565261DOI Listing
February 2019
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Improving HPV vaccine delivery at school-based health centers.

Hum Vaccin Immunother 2019 Feb 8. Epub 2019 Feb 8.

a New York City Department of Health and Mental Hygiene , Bureau of Immunization , Queens , NY , USA.

Objective: To identify characteristics associated with human papilloma virus (HPV) vaccination rates, describe barriers and facilitators to vaccine uptake and the potential role for clinician-to-clinician Assessment, Feedback, Incentives, and eXchange (AFIX) visits in school-based health centers (SBHCs).

Methods: We conducted clinician-to-clinician AFIX visits at 24 New York City (NYC) high-school and middle-school SBHCs with up-to-date adolescent vaccination rates below 40%. Using NYC's immunization information system, we assessed HPV initiation and series completion rates at the time of AFIX visit and follow-up three to five months later. Read More

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http://dx.doi.org/10.1080/21645515.2019.1578596DOI Listing
February 2019

Provider-level rates of HEDIS-consistent HPV vaccination in a regional health plan.

Hum Vaccin Immunother 2019 Feb 8. Epub 2019 Feb 8.

a Department of Population Medicine , Harvard Medical School & Harvard Pilgrim Health Care Institute , Boston , MA , USA.

Background: Health insurers are well-positioned to address low HPV vaccination coverage in the US through initiatives such as provider assessment and feedback. However, little is known about the feasibility of using administrative claims data to assess provider performance on vaccine delivery.

Methods: We used administrative claims data from a regional health plan to estimate provider performance on the 2013-2015 Healthcare Effectiveness Data and Information Set (HEDIS) measure for HPV vaccine. Read More

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http://dx.doi.org/10.1080/21645515.2019.1574150DOI Listing
February 2019

Nativity status and genital HPV infection among adults in the U.S.

Hum Vaccin Immunother 2019 Feb 8. Epub 2019 Feb 8.

d Division of General Pediatrics and Adolescent Health , University of Minnesota Medical School , Minneapolis , MN.

Over 43 million immigrants live in the United States (U.S.). Read More

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http://dx.doi.org/10.1080/21645515.2019.1578592DOI Listing
February 2019

Mass psychogenic illness following HPV immunization in Carmen de Bolivar, Colombia (2014): more uncertainty is required.

Hum Vaccin Immunother 2019 Feb 8. Epub 2019 Feb 8.

a Public Health Department , School of Medicine, Universidad Industrial de Santander , Bucaramanga , Colombia.

The interesting article by Simas et. al. describes an outbreak case with over 600 individuals who exhibited neurological symptoms and which occurred in a town located at the northern region of Colombia in 2014. Read More

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http://dx.doi.org/10.1080/21645515.2019.1577676DOI Listing
February 2019

Using the precaution adoption process model to clarify human papillomavirus vaccine hesitancy in canadian parents of girls and parents of boys.

Hum Vaccin Immunother 2019 Feb 8. Epub 2019 Feb 8.

a Lady Davis Institute for Medical Research , Jewish General Hospital , Montreal , Quebec , Canada.

Background: Achieving optimal human papillomavirus (HPV) vaccine uptake can be delayed by parents' HPV vaccine hesitancy, which is as a multi-stage intention process rather than a dichotomous (vaccinated/not vaccinated) outcome. Our objective was to longitudinally explore HPV related attitudes, beliefs and knowledge and to estimate the effect of psychosocial factors on HPV vaccine acceptability in HPV vaccine hesitant parents of boys and girls.

Methods: We used an online survey to collect data from a nationally representative sample of Canadian parents of 9-16 years old boys and girls in September 2016 and July 2017. Read More

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http://dx.doi.org/10.1080/21645515.2019.1575711DOI Listing
February 2019

Self-digitization chip for quantitative detection of human papillomavirus gene using digital LAMP.

Lab Chip 2019 Feb 8. Epub 2019 Feb 8.

Department of Chemistry, University of Washington, Seattle, Washington 98195, USA.

Digital nucleic acid amplification and detection methods provide excellent sensitivity and specificity and allow absolute quantification of target nucleic acids. Isothermal methods such as digital loop-mediated isothermal amplification (digital LAMP) have potential for use in rapid disease diagnosis in low-resource settings due to their speed and lack of thermal cycling. We previously developed a self-digitization (SD) chip, a simple microfluidics device that automatically digitizes a sample into an array of nanoliter wells, for use in digital LAMP. Read More

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http://dx.doi.org/10.1039/c8lc01223gDOI Listing
February 2019

Tumor stromal desmoplasia and inflammatory response uniquely predict survival with and without stratification for HPV tumor infection in OPSCC patients.

Acta Otolaryngol 2019 Feb 8:1-8. Epub 2019 Feb 8.

f Department of Clinical Medicine , University of Bergen, Haukeland University Hospital , Bergen , Norway.

Background: Oropharyngeal squamous cell carcinoma (OPSCC) positive for human papillomavirus (HPV) increases wolrd wide.

Aims/objectives: The objective for this study has been to evaluate tumor phenotypes and tumor host responses with respect to five-year disease-specific survival (DSS) in HPV(+) and HPV(-) patients.

Material And Methods: Two hundred patients with OPSCC have been treated between 1992 and 2010. Read More

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http://dx.doi.org/10.1080/00016489.2018.1497809DOI Listing
February 2019
2 Reads