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    Design and statistical considerations for studies evaluating the efficacy of a single dose of the human papillomavirus (HPV) vaccine.
    Contemp Clin Trials 2018 Feb 20. Epub 2018 Feb 20.
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, 7E594, Rockville, MD 20850, United States. Electronic address:
    Cervical cancer is a leading cause of cancer mortality in women worldwide. Human papillomavirus (HPV) types 16 and 18 cause about 70% of all cervical cancers. Clinical trials have demonstrated that three doses of either commercially available HPV vaccine, Cervarix or Gardasil, prevent most new HPV 16/18 infections and associated precancerous lesions. Read More

    Cross-sectional associations between psychological traits, and HPV vaccine uptake and intentions in young adults from the United States.
    PLoS One 2018 23;13(2):e0193363. Epub 2018 Feb 23.
    Department of Epidemiology, University of Iowa, Iowa City, Iowa, United States of America.
    Human papillomavirus (HPV) is the most prevalent sexually transmitted infection worldwide and can lead to the development of genital warts, and cancers throughout the body. Despite the availability of HPV vaccines for over a decade, uptake in the United States among adolescents and young adults remains well below national targets. While most efforts to improve HPV vaccine uptake have rightly focused on adolescents, there is still a tremendous opportunity to improve vaccination among young adults who have not been vaccinated against HPV. Read More

    De-escalation treatment of human papillomavirus-positive oropharyngeal squamous cell carcinoma: an evidence-based review for the locally advanced disease.
    Curr Opin Oncol 2018 Feb 22. Epub 2018 Feb 22.
    Medical Oncology, Instituto do Cancer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
    Purpose Of Review: Oropharyngeal cancer (OPC) incidence is increasing worldwide, especially in developed countries where it seems to be etiologically related to the elevating rates of high-risk human papillomavirus (HPV) infection. Considered a distinct disease because of its weak correlation with the traditional risk factors (tobacco use and alcohol), it has different patterns of survival outcomes, locoregional and distant failure, generally with better prognosis independently of the treatment. The standard therapeutic approach for locally advanced (LA) OPCs includes radiation therapy with concurrent chemotherapy, resulting in severe toxicities with negative impacts in quality of life (QoL). Read More

    Anticipating the Impact of Human Papillomavirus Vaccination on US Cervical Cancer Prevention Strategies.
    J Low Genit Tract Dis 2018 Feb 23. Epub 2018 Feb 23.
    Washington University School of Medicine, St Louis, MO.
    Cervical cancer prevention guidelines are benchmarked to risk of cervical precancer. In younger age cohorts, vaccination against high-risk types of human papillomavirus (HPV) has reduced HPV 16/18 prevalence and cervical intraepithelial neoplasia. Lower prevalence of precancer will impair the sensitivity of cytology and colposcopy, but negative predictive value will rise. Read More

    High Rates of High-Grade Cervical Dysplasia in High-Risk Young Women With Low-Grade Cervical Cytology.
    J Low Genit Tract Dis 2018 Feb 23. Epub 2018 Feb 23.
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL.
    Objective: The aim of the study was to determine rates of cervical intraepithelial neoplasia (CIN) 2 or greater in high-risk, racially diverse, young women with low-grade cytology.

    Materials And Methods: After institutional review board approval, a cross-sectional study of 21- to 24-year-old women with low-grade cytology (atypical squamous cells of undetermined significance, high-risk human papillomavirus+, low-grade squamous intraepithelial lesion, or human papillomavirus+ only) managed with colposcopy at our university-based clinic between May 2011 and April 2013 were identified. Demographics and pathologic data were collected including age, race, parity, smoking status, screening history, and histology. Read More

    Effect of High-Risk Human Papillomavirus but Normal Cytology at Test of Cure on Achieving Colposcopy Standards.
    J Low Genit Tract Dis 2018 Feb 23. Epub 2018 Feb 23.
    Department of Gynaecologic Oncology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom.
    Objective: In United Kingdom., test of cure after treatment of any grade of cervical intraepithelial neoplasia (CIN) incorporates high-risk human papillomavirus (Hr-HPV) test and cytology at 6-month follow-up. The aims of the study were to determine the rate of recurrent CIN in women who are Hr-HPV positive and cytology negative and to explore possible associated risk factors. Read More

    Health-Related Quality of Life of Patients with HPV-Related Cancers in Indonesia.
    Value Health Reg Issues 2017 Sep 3;15:63-69. Epub 2017 Sep 3.
    Unit of PharmacoEpidemiology & PharmacoEconomics (PE2), Department of Pharmacy, University of Groningen, Groningen, The Netherlands; Institute of Science in Healthy Aging & healthcaRE (SHARE), University Medical Center Groningen, Groningen, The Netherlands.
    Background: Human papillomavirus (HPV)-related cancers are a serious concern in developing countries. Valid estimates of a country-specific health-related quality of life (HRQOL) for patients with HPV-related cancers provide a substantial tool in determining the burden of the disease.

    Objectives: To investigate the HRQOL of patients with HPV-related cancers in Indonesia. Read More

    Resource Use and Cost of Treating Human Papillomavirus-Related Lesions in Japanese Women.
    Value Health Reg Issues 2017 Sep 1;15:56-62. Epub 2017 Sep 1.
    Health Economics, Vaccines Value and Health Science, GSK, Wavre, Belgium.
    Background: Human papillomavirus (HPV) infection is established as a necessary causal factor in several pathologies including cervical cancer (CC), which recorded over 11,000 new cases in 2011 in Japan. Nevertheless, cost burden data of human papillomavirus-related diseases in Japan are lacking.

    Objectives: To evaluate resource use and costs in women with HPV-related lesions. Read More

    Improving Provider Communication about HPV Vaccines for Vaccine-Hesitant Parents Through the Use of Motivational Interviewing.
    J Health Commun 2018 Feb 23:1-8. Epub 2018 Feb 23.
    a Adult and Child Consortium for Health Outcomes Research and Delivery Science , University of Colorado Denver , Aurora , USA.
    Human papillomavirus (HPV) vaccine uptake is below that of other routine adolescent vaccines. This is due in part to the fact that the HPV vaccine is often not routinely recommended by providers to all eligible adolescents. While providers' recommendations are crucial, even a strongly stated recommendation can be insufficient among HPV vaccine-hesitant parents. Read More

    Kansas Provider Report of Adolescent Vaccinations in Their Practice.
    Kans J Med 2017 Nov 30;10(4):1-14. Epub 2017 Nov 30.
    University of Kansas School of Medicine-Wichita, Department of Pediatrics.
    Background: Kansas falls consistently below average for adolescent vaccination of meningococcal (MCV), human papillomavirus (HPV), and influenza.

    Methods: For this study, the members of Kansas Chapter of the American Academy of Pediatrics were emailed a confidential electronic survey soliciting their impressions of vaccination in their practice.

    Results: Of 137 providers emailed, 61 (45%) completed the survey. Read More

    HPV-transformed cells exhibit altered HMGB1-TLR4/MyD88-SARM1 signaling axis.
    Sci Rep 2018 Feb 22;8(1):3476. Epub 2018 Feb 22.
    Department of Microbiology, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo, Brazil.
    Cervical cancer is one of the leading causes of cancer death in women worldwide. Persistent infection with high-risk human papillomavirus (HPV) types is the main risk factor for the development of cervical cancer precursor lesions. HPV persistence and tumor development is usually characterized by innate immune system evasion. Read More

    Oropharyngeal HPV infection: prevalence and sampling methods among HIV-infected men in South Africa.
    Int J STD AIDS 2018 Jan 1:956462418755882. Epub 2018 Jan 1.
    1 Wits RHI, Faculty of Health Sciences, 37707 University of the Witwatersrand , Johannesburg, South Africa.
    Worldwide, 96,000 cases of oropharyngeal cancer (OPC) occurred in 2012. Human papillomavirus (HPV) is a risk factor for OPC. Data on oropharyngeal HPV infection are limited. Read More

    Coaching primary care clinics for HPV vaccination quality improvement: Comparing in-person and webinar implementation.
    Transl Behav Med 2018 Feb 20. Epub 2018 Feb 20.
    Department of Health Behavior, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
    State health departments commonly use quality improvement coaching as an implementation strategy for improving low human papillomavirus (HPV) vaccination coverage, but such coaching can be resource intensive. To explore opportunities for improving efficiency, we compared in-person and webinar delivery of coaching sessions on implementation outcomes, including reach, acceptability, and delivery cost. In 2015, we randomly assigned 148 high-volume primary care clinics in Illinois, Michigan, and Washington State to receive either in-person or webinar coaching. Read More

    Influence of Prior Knowledge of Human Papillomavirus Status on the Performance of Cytology Screening.
    Am J Clin Pathol 2018 Feb 17. Epub 2018 Feb 17.
    Instituto Nacional de Ciência e Tecnologia das Doenças do Papilomavírus Humano, São Paulo, Brazil.
    Objectives: This study aimed to evaluate the influence of prior knowledge of human papillomavirus (HPV) status in cervical cytopathology readings.

    Methods: Participants comprised 2,376 women who underwent parallel cytology and HPV-DNA testing. Smears were read twice by the same team, first with previous knowledge of HPV-DNA status. Read More

    Male Undergraduates' HPV Vaccination Behavior: Implications for Achieving HPV-Associated Cancer Equity.
    J Community Health 2018 Feb 22. Epub 2018 Feb 22.
    HealthPartners Institute, Bloomington, MN, USA.
    Despite the availability of the human papillomavirus (HPV) vaccine for males, uptake of the vaccine has been low, particularly among young adult males. This study aimed to investigate the levels of HPV vaccination and predictors of HPV vaccine completion in college men ages 18-26. We analyzed data from the 2015 College Student Health Survey, which was administered at 17 post-secondary institutions in Midwest areas. Read More

    [Molecular characterization of penile cancer : Literature review of new prognostic markers and potential therapeutic targets].
    Urologe A 2018 Feb 22. Epub 2018 Feb 22.
    Urologische Klinik, Caritas-Krankenhaus St. Josef, Universität Regensburg, Regensburg, Deutschland.
    Squamous cell carcinoma of the penis (SCCP) is a rare cancer type in Western industrialized nations; nevertheless, it shows an aggressive course of disease in advanced tumor stages with accordantly high recurrence and progression rates. While molecular biomarkers are not established in clinical routine for the management of SCCP patients yet, the accordant unmet need is enormous, as adequate biomarkers would be meaningful for prognostic determination, planning of modality and extent of primary therapy, indication for inguinal lymph node resection, adjuvant treatment, and as potential targets for specific systemic treatment. SCCP regularly develops from a precursor lesion. Read More

    Expression of Yin Yang 1 in cervical cancer and its correlation with E-cadherin expression and HPV16 E6.
    PLoS One 2018 22;13(2):e0193340. Epub 2018 Feb 22.
    Center of Reproductive Medicine, the first Affiliated Hospital of Guangxi Medical University, Nanning, China.
    The molecular mechanisms of normal cervical squamous epithelium advancing to cervical intraepithelial neoplasia (CIN) and eventually to cervical squamous cell carcinoma (CSCC) are largely unknown. This study explored abnormal expression of Yin Yang 1 (YY1) in cervical cancer and its correlation with the expression of E-cadherin and human papillomavirus (HPV) 16 E6. YY1, E-cadherin and HPV16 E6 expression were detected by immunohistochemistry in 90 cervical tissue specimens collected from 30 patients with hysteromyoma, 15 patients with CIN I, 15 patients with CIN II-III, and 30 patients with CSCC. Read More

    Is Vulvovaginal Lichen Planus Associated With Squamous Cell Carcinoma?
    J Low Genit Tract Dis 2018 Feb 22. Epub 2018 Feb 22.
    Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia.
    Objective: The aim of the study was to assess for the presence of vulvar lichen planus (LP) in association with human papillomavirus (HPV)-independent squamous cell carcinoma (SCC).

    Materials And Methods: We performed a clinicohistopathologic review of consecutive vulvectomies and wide local excisions for HPV-independent vulvar or vaginal SCC from 2007 to 2017. Data collected included site of SCC, adjacent precursor lesions and dermatoses, dermatologic treatment, and outcome. Read More

    Role of Race/Ethnicity, Language, and Insurance in Use of Cervical Cancer Prevention Services Among Low-Income Hispanic Women, 2009-2013.
    Prev Chronic Dis 2018 Feb 22;15:E25. Epub 2018 Feb 22.
    Oregon Health and Science University, Portland, Oregon.
    Introduction: Hispanic women in the United States have an elevated risk of cervical cancer, but the existing literature does not reveal why this disparity persists.

    Methods: We performed a retrospective cohort analysis of 17,828 low-income women aged 21 to 64 years seeking care at Oregon community health centers served by a hosted, linked electronic health record during 2009 through 2013. We assessed the odds of having had Papanicolaou (Pap) tests and receiving human papillomavirus (HPV) vaccine, by race/ethnicity, insurance status, and language. Read More

    What Drives Health Professionals to Tweet About #HPVvaccine? Identifying Strategies for Effective Communication.
    Prev Chronic Dis 2018 Feb 22;15:E26. Epub 2018 Feb 22.
    Microsoft Research Israel, Herzeliya, Israel.
    Introduction: We conducted this study to quantify how health professionals use Twitter to communicate about the human papillomavirus (HPV) vaccine.

    Methods: We collected 193,379 tweets from August 2014 through July 2015 that contained key words related to HPV vaccine. We classified all tweets on the basis of user, audience, sentiment, content, and vaccine characteristic to examine 3 groups of tweets: 1) those sent by health professionals, 2) those intended for parents, and 3) those sent by health professionals and intended for parents. Read More

    A Qualitative Comparative Analysis of Combined State Health Policies Related to Human Papillomavirus Vaccine Uptake in the United States.
    Am J Public Health 2018 Feb 22:e1-e7. Epub 2018 Feb 22.
    At the time of this work, Megan C. Roberts, Jennifer L. Moss, and Christopher W. Wheldon were with the National Cancer Institute, Rockville, MD. Taylor Murphy was with George Washington University, Washington, DC. Wayne Psek was with the Milken Institute School of Public Health, George Washington University.
    Objectives: To examine how combinations of state policies, rather than single policies, are related to uptake of human papillomavirus (HPV) vaccine.

    Methods: Using publicly available records and the literature, we characterized policies for each US state and Washington, DC, in 2015 (n = 51), including (1) Medicaid expansion, (2) policies permitting HPV vaccination in pharmacies, (3) school-entry requirements, (4) classroom sex education mandates, and (5) parental education mandates. Using qualitative comparative analysis, we identified which existing combinations of these policies were necessary and sufficient for high HPV vaccine initiation among adolescents, with National Immunization Survey-Teen data. Read More

    Diverse papillomaviruses identified in Weddell seals.
    J Gen Virol 2018 Feb 22. Epub 2018 Feb 22.
    8​Structural Biology Research Unit, Department of Clinical Laboratory Sciences, University of Cape Town, Rondebosch, 7701, Cape Town, South Africa.
    Papillomaviridae is a diverse family of circular, double-stranded DNA (dsDNA) viruses that infect a broad range of mammalian, avian and fish hosts. While papillomaviruses have been characterized most extensively in humans, the study of non-human papillomaviruses has contributed greatly to our understanding of their pathogenicity and evolution. Using high-throughput sequencing approaches, we identified 7 novel papillomaviruses from vaginal swabs collected from 81 adult female Weddell seals (Leptonychotes weddellii) in the Ross Sea of Antarctica between 2014-2017. Read More

    Major clinical research advances in gynecologic cancer in 2017.
    J Gynecol Oncol 2018 Mar;29(2):e31
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
    In 2017, 10 topics were selected as major clinical research advances in gynecologic oncology. For cervical cancer, efficacy and safety analysis results of a 9-valent human papillomavirus (HPV) vaccine and long-term impact of reduced dose of quadrivalent vaccine were updated. Brief introduction of KEYNOTE trials of pembrolizumab, a monoclonal antibody that blocks the interaction between programmed death (PD)-1 and its ligands, PD-L1 and PD-L2, followed. Read More

    [Pathology and histopathological evaluation of penile cancer].
    Urologe A 2018 Feb 21. Epub 2018 Feb 21.
    Institut für Pathologie, Universitätsmedizin Rostock, Strempelstraße 14, 18057, Rostock, Deutschland.
    Background: Penile cancer is rare in Germany and in western European countries. Our understanding of the pathogenesis and pathology of this malignancy has increased considerably in recent years.

    Objectives: Clinical management has become more complex, with organ-preserving strategies being increasingly favored. Read More

    [Epidemiology of penile cancer].
    Urologe A 2018 Feb 21. Epub 2018 Feb 21.
    Klinik für Urologie und Kinderurologie, Campus Kiel, Universitätsklinikum Schleswig-Holstein, Arnold-Heller-Straße 3, 24105, Kiel, Deutschland.
    Background: Penile cancer represents a rarity in daily clinical practice.

    Objectives: The aim is to identify global differences concerning the incidence, social and risk factors.

    Methods: The past and current epidemiologic literature is analyzed concerning incidence rates and risk factors. Read More

    [The innate immune system in oropharyngeal squamous cell carcinoma : Immune modulation by HPV].
    HNO 2018 Feb 15. Epub 2018 Feb 15.
    Klinik für HNO-Heilkunde, Kopf‑, Halschirurgie, Universitätsklinikum Gießen, Justus-Liebig-Universität Gießen, Gießen, Deutschland.
    Based on clinical and experimental data, oropharyngeal squamous cell carcinomas (OPSCC) associated with human papillomavirus (HPV) have been recognized as a distinct entity of head and neck cancers. However, outside of clinical trials, HPV status currently has no impact on treatment. The natural replication cycle of HPV takes place in epithelial cells, and is thus spatially separated from cytotoxic immune cells in the epidermis. Read More

    Retinoic acid receptor beta promoter methylation and risk of cervical cancer.
    World J Virol 2018 Feb;7(1):1-9
    Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.
    Cervical cancer is one of the leading causes of death in women worldwide, particularly in developing countries. Human papillomavirus has been reported as one of the key etiologic factors in cervical carcinoma. Likewise, epigenetic aberrations have ability to regulate cancer pathogenesis and progression. Read More

    Toll-like receptor 2 induces adenosine receptor A2a and promotes human squamous carcinoma cell growth via extracellular signal regulated kinases ½.
    Oncotarget 2018 Jan 30;9(6):6814-6829. Epub 2017 Dec 30.
    Dental College of Georgia, Augusta University, Augusta, GA, USA.
    Patient treatment for oral squamous cell carcinoma (OSCC) not associated withremains problematic. OSCC microenvironment is typically inflamed and colonized by microorganisms, providing ligands for toll-like receptors (TLR). In immune cells TLR2 and TLR4 activate NF-kB and extracellular signal regulated kinase (ERK)1/2 pathways, leading to upregulation of inhibitory adenosine receptors A2a and A2b, and reduction in stimulatory A1 and A3. Read More

    Mitochondrial Proteins Coded by Human Tumor Viruses.
    Front Microbiol 2018 6;9:81. Epub 2018 Feb 6.
    Veneto Institute of Oncology IOV-IRRCS, Padova, Italy.
    Viruses must exploit the cellular biosynthetic machinery and evade cellular defense systems to complete their life cycles. Due to their crucial roles in cellular bioenergetics, apoptosis, innate immunity and redox balance, mitochondria are important functional targets of many viruses, including tumor viruses. The present review describes the interactions between mitochondria and proteins coded by the human tumor viruses human T-cell leukemia virus type 1, Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, human hepatitis viruses B and C, and human papillomavirus, and highlights how these interactions contribute to viral replication, persistence and transformation. Read More

    Separate analysis of human papillomavirus E6 and E7 messenger RNAs to predict cervical neoplasia progression.
    PLoS One 2018 21;13(2):e0193061. Epub 2018 Feb 21.
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
    A few studies previously suggested that human papillomavirus (HPV) E6 messenger RNA (mRNA) may exist uniformly in all grades of cervical intraepithelial neoplasia (CIN), whereas the detection rate of E7 mRNA may increase with disease progression from low-grade CIN to invasive carcinoma. The aim of this study was to clarify the different roles of E6 and E7 mRNAs in cervical carcinogenesis. The presence of each E6 and E7 mRNA was analyzed in 171 patients with pathologically-diagnosed CIN or cervical carcinoma. Read More

    Differential Expression of MicroRNAs in Uterine Cervical Cancer and Its Implications in Carcinogenesis; An Integrative Approach.
    Int J Gynecol Cancer 2018 Mar;28(3):553-562
    Objectives: Cervical cancer is the second most common cancer in women in developing countries, including India. Recently, microRNAs (miRNAs) are gaining importance in cancer biology because of their involvement in various cellular processes. The present study aimed to profile miRNA expression pattern in cervical cancer, identify their target genes, and understand their role in carcinogenesis. Read More

    Early evidence of the effectiveness of the human papillomavirus vaccination program against anogenital warts in Manitoba, Canada: A registry cohort study.
    Sex Transm Dis 2017 Oct 10. Epub 2017 Oct 10.
    Department of Community Health Sciences, Rady Faculty of Health Sciences, University of Manitoba, S113-750 Bannatyne Avenue, Winnipeg, Manitoba, Canada R3E 0W3.
    Background: We assessed the effectiveness of the qHPV vaccination program in Manitoba, Canada in reducing incident AGWs, and to what extent effectiveness depends on age at vaccination, and number of doses.

    Methods: Females ≥ 9 years old who received the qHPV in Manitoba between September 2006 and March 2013 (N=31,464) through the publicly-funded school-based program and a high-risk catch-up program were included. They were matched on age and area of residence to unvaccinated females. Read More

    High Baseline Anal HPV and Abnormal Anal Cytology in a Phase 3 Trial of the Quadrivalent HPV Vaccine in HIV-infected individuals over 26 years old: ACTG 5298.
    Sex Transm Dis 2017 Oct 13. Epub 2017 Oct 13.
    Background: The quadrivalent human papillomavirus (HPV) vaccine (qHPV; types 6, 11, 16, 18) is indicated for men and women 9-26 years to prevent HPV associated anogenital high grade squamous intraepithelial lesions (HSIL) and cancer. ACTG 5298 was a randomized placebo controlled Phase 3 study in HIV-infected men who have sex with men (MSM), and women of qHPV to prevent persistent anal HPV infection. Baseline data is presented here. Read More

    Genital Wart and HPV Prevalence in Males in the United States from Penile Swabs: Results from NHANES.
    Sex Transm Dis 2017 Nov 16. Epub 2017 Nov 16.
    Department of Urology, SUNY Upstate Medical University, Syracuse, NY.
    Introduction: Human papillomavirus (HPV) is a common sexually transmitted infection in the US that can lead to both malignant (high risk) and benign (low risk) findings. These low risk findings include both genital condyloma, anal warts, and adult or juvenile papillomatosis, which are directly attributable to subtypes HPV 6 and HPV 11. We aim to estimate the prevalence of genital wart infections in males in the US population using a nationwide sample. Read More

    A prospective study of women with ASCUS or LSIL pap smears at baseline and HPV E6/E7 mRNA positive: a 3-year follow-up.
    Epidemiol Infect 2018 Feb 21:1-7. Epub 2018 Feb 21.
    Department of General Surgery and Medical Surgical Specialties,Gynecological Clinic of the Policlinico universitario,via s.sofia 78, 95124, Catania,Italy.
    Human papillomavirus (HPV) testing is used in the triage of women with a borderline smear result. The efficiency of testing women with a low-grade squamous intraepithelial lesion (LSIL) and atypical squamous cells of undetermined significance (ASCUS) is less clear. For this reason we used a new HPV test that detects E6/E7 messenger RNA (mRNA), which might have a higher specificity. Read More

    Prevalence of potential sexual abuse in adolescents and young adults and feasibility of an assessment and management plan used in three research projects.
    Res Nurs Health 2018 Feb 21. Epub 2018 Feb 21.
    Division of Adolescent and Transition Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
    The aims of this study were to examine the feasibility of a protocol to assess for assessment and response to potential sexual abuse (defined as self-report of sexual initiation before age 13) among adolescent and young adult research participants in human papillomavirus (HPV) vaccination screening; determine the proportion of participants whose survey responses indicated potential sexual abuse and assess whether age, gender, race, and recruitment site were associated with potential abuse. We pooled data from three cross-sectional studies of 13-26 year-old women and men (N = 1541) recruited at a Teen Health Center (THC) and Health Department (HD). Using written and electronic documentation, we demonstrated feasibility by the following outcomes: 100% of participants who indicated early sexual initiation were interviewed by the research staff, 100% of assessments were disclosed to participants' primary care clinicians, and no adverse consequences of the interviews or referrals occurred. Read More

    Human papillomavirus E7 oncoprotein expression by keratinocytes alters the cytotoxic mechanisms used by CD8 T cells.
    Oncotarget 2018 Jan 14;9(5):6015-6027. Epub 2017 Dec 14.
    University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Brisbane, Qld, Australia.
    Cervical cancer is a malignant transformation of keratinocytes initiated by the E7 oncoprotein of human papillomavirus (HPV). These tumors are characterized by keratinocyte hyperproliferation and are often infiltrated with activated CD8 T cells. HPV infection confers changes to gain immunological advantage to promote chronic infection, and these persist with malignant transformation. Read More

    Peptidomic Analysis of Female Reproductive Tract Secretion to Identify Putative Anti-Infection Peptides in the Female Genital System via Nanotechnologies.
    J Biomed Nanotechnol 2018 Jan;14(1):215-226
    The female genital system infections have high-incidence among various gynecological diseases. The role of endogenous peptides in female reproductive tract secretion has been rarely investigated regarding gynecological infections. To identify gynecological infections associated endogenous peptides, a comparative peptidomic profiling of vaginal secretion from sexually mature and perimenopause women was conducted in this study using nanoflow liquid chromatography-tandem mass spectrometer. Read More

    The Impact of Education About Cervical Cancer and Human Papillomavirus on Women's Healthy Lifestyle Behaviors and Beliefs: Using the PRECEDE Educational Model.
    Cancer Nurs 2018 Feb 14. Epub 2018 Feb 14.
    Author Affiliations: Health Science Faculty, Department of Nursing (Dr Koç); Medicine Faculty, Department of Obstetric Gynecology (Mrs Özdeş); Health Science Faculty, Department of Midwifery (Dr Topatan); and Health Services Vocational School (Mrs Çinarli and Dr Şener), Ondokuz Mayis University, Samsun; Ahmet Erdoğan Health Services Vocational School, Bülent Ecevit University, Zonguldak (Mrs Danaci); and Health Services Vocational School, Gümüşhane University (Mrs Palazoğlu), Turkey.
    Background: Early detection of cervical cancer improves the chances of successful treatment.

    Objective: The aim of this study was to determine the effect of education about cervical cancer and human papillomavirus on the healthy lifestyle, behavior, and beliefs of Turkish women who were without cancer, using the PRECEDE education model.

    Methods: This qualitative and quantitative study was conducted as a prospective, randomized, 2-group (intervention and control) trial at a community training center in north Turkey. Read More

    Human papilloma virus in the tonsillar microbiota of an Afghan population group.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):191-196
    CUFS, University of San Marino.
    Cancer of the oral cavity is known to have a diverse aetiology that includes infectious agents. Human papilloma virus has been found to be associated with several types of human cancer, inclusive of cervical, vulvar, vaginal, penile, anal, and cancer of tonsil. The aim of this manuscript is to investigate the presence of human papilloma virus in tonsillar microbiota of an Afghan population group. Read More

    Immediate biopsy of cervical cytology-negative and non-HPV-16/18 oncogenic types positive patients.
    Diagn Cytopathol 2018 Feb 19. Epub 2018 Feb 19.
    Bakırköy Dr. Sadi Konuk Education and Reseach Hospital Obstetrics and Gynecology, İstanbul TR 34147, Turkey.
    Background: According to the American Society of Colposcopy and Cervical Pathology (ASCCP), a co-test is recommended for patients one year after the detection of non-HPV 16/18 viral types in association with a negative cervical cytology. In this study, we used immediate colposcopy to evaluate the risks to the patient during the one year waiting period.

    Methods: We included 544 Hpv-positive/cervical cytology-negative patients who underwent cervical cancer screening from June 2015 to June 2017. Read More

    β-HPV Infection Correlates with Early Stages of Carcinogenesis in Skin Tumors and Patient-Derived Xenografts from a Kidney Transplant Recipient Cohort.
    Front Microbiol 2018 5;9:117. Epub 2018 Feb 5.
    Virology Unit, Department of Translational Medicine, Novara Medical School, University of Eastern Piedmont, Novara, Italy.
    Many malignancies that occur in high excess in kidney transplant recipients (KTRs) are due to viruses that thrive in the setting of immunosuppression. Keratinocyte carcinoma (KC), the most frequently occurring cancer type in KTR, has been associated with skin infection by human papillomavirus (HPV) from the beta genus. In this report, we extend our previous investigation aimed at identifying the presence of active β-HPV infection in skin tumors from KTRs through detection of viral protein expression. Read More

    The role of human papillomavirus vaccines in cervical cancer: Prevention and treatment.
    Crit Rev Oncol Hematol 2018 Feb 28;122:92-97. Epub 2017 Dec 28.
    Gynecologic Oncology, IRCCS National Cancer Institute, Milan, Italy.
    Human papillomavirus (HPV) is the most common sexually transmitted disease, worldwide. Primary prevention thorough vaccination si able to reduce the burden of HPV-related lesions. Ten years ago the Food and drug Administration (FDA) approved the first vaccine against HPV. Read More

    The contribution of SP100 to cottontail rabbit papillomavirus transcription and replication.
    J Gen Virol 2018 Jan 24. Epub 2018 Jan 24.
    Division of Experimental Virology, University Hospital Tuebingen, Institute for Medical Virology and Epidemiology of Viral Diseases, Tuebingen, Germany.
    SP100 proteins are components of nuclear domain 10 structures and have been implicated as inhibitors of human papillomavirus (HPV) replication. In this study, we have addressed the role of SP100 in tumour formation by the cottontail rabbit (Sylvilagus floridanus) papillomavirus (CRPV or SfPV1) in a rabbit model. Tissue culture studies using rabbit keratinocyte lines indicated that rabbit SP100 is an interferon-beta-inducible gene similar to its human counterpart. Read More

    Agreement of self- and physician-collected samples for detection of high-risk human papillomavirus infections in women attending a colposcopy clinic in Thailand.
    BMC Res Notes 2018 Feb 20;11(1):136. Epub 2018 Feb 20.
    Data Management Unit, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand.
    Objective: To study the concordance between vaginal self- and endocervical physician-collected high-risk (hr) HPV testing in Thai women who attended a colposcopy clinic. Vaginal samples were obtained by self-sampling with a dry brush before endocervical samples were obtained by physicians. Both specimens were analyzed for hrHPV by Cobas4800 HPV test. Read More

    Hospitalization Burden Associated with Malignant Neoplasia and In Situ Carcinoma in Vulva and Vagina during a 5-Year Period (2009-2013) in Spain: an Epidemiological Study.
    Papillomavirus Res 2018 Feb 16. Epub 2018 Feb 16.
    Area of Preventive Medicine and Public Health. University Rey Juan Carlos, Madrid, Spain.
    Background: Vulvar and vaginal cancers are considered rare cancers in women. Human Papillomavirus is responsible for 30%-76% of them. The aim of this study was to describe the burden of hospital admissions by malignant neoplasia (MN) and in situ carcinoma (ISC) of vulva and vagina from 2009 to 2013, in Spain METHODS: This observational, descriptive study used discharge information obtained from the national surveillance system for hospital data, Conjunto Mínimo Básico de Datos, CMBD, provided by the Ministry of Health. Read More

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