45,893 results match your criteria Human Papillomavirus


Sexually transmitted infections among HIV-infected and HIV-uninfected women in the Tapajós region, Amazon, Brazil: Self-collected vs. clinician-collected samples.

PLoS One 2019 23;14(4):e0215001. Epub 2019 Apr 23.

Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

The anogenital prevalence of sexually transmitted infections (STIs) and the use of cervico-vaginal self-collected vs. clinician-collected samples were evaluated for the diagnosis of human immunodeficiency virus (HIV)-infected and HIV-uninfected women in the Tapajós region, Amazon, Brazil. We recruited 153 women for a cross-sectional study (112 HIV-uninfected and 41 HIV-infected) who sought health services. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215001PLOS

Survival outcomes by high-risk human papillomavirus status in nonoropharyngeal head and neck squamous cell carcinomas: A propensity-scored analysis of the National Cancer Data Base.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.

Background: The prognostic relevance of human papillomavirus (HPV) status in patients with nonoropharyngeal (OPX) squamous cell cancer (SCC) of the head and neck is controversial. In the current study, the authors evaluated the impact of high-risk HPV status on overall survival (OS) in patients with non-OPX SCC using a large database approach.

Methods: The National Cancer Data Base was queried to identify patients diagnosed from 2004 through 2014 with SCC of the OPX, hypopharynx (HPX), larynx, and oral cavity (OC) with known HPV status. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32115
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http://dx.doi.org/10.1002/cncr.32115DOI Listing
April 2019
1 Read

Epidemiology of Head and Neck Squamous Cell Carcinomas: Impact on Staging and Prevention Strategies.

Curr Treat Options Oncol 2019 Apr 22;20(5):43. Epub 2019 Apr 22.

Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, 12801 18 E. 17th Ave, MS 8117, Aurora, CO, 80045, USA.

Opinion Statement: The epidemiology of head and neck squamous cell carcinoma (HNSCC) has shifted dramatically over the last 50 years, as smoking-related HNSCCs decrease in incidence while human papillomavirus (HPV)-related cancers rise. The shift in HNSCC risk factors has changed patient demographics, the distribution of affected anatomical subsites, and prognosis of this illness. As such, the medical community has responded by devising novel staging systems and prevention strategies. Read More

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http://dx.doi.org/10.1007/s11864-019-0650-5DOI Listing

Benign epithelial oral lesions - association with human papillomavirus.

Med Oral Patol Oral Cir Bucal 2019 Apr 23. Epub 2019 Apr 23.

Oral Pathology, Piracicaba Dental School University of Campinas (UNICAMP) Av. Limeira 901, P.O. Box 52, 13414-903 Piracicaba, São Paulo, Brazil

Background: The presence of human papilloma virus in benign oral lesions has been studied by different techniques obtaining extremely variable results. The objective of this study was to determine the presence of human papillomavirus in 83 cases of benign hyperplastic epithelial oral lesions.

Material And Methods: Eighty-three oral lesions with clinical or histopathological features suggestive of HPV infection were retrieved from the files of four oral pathology services. Read More

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http://dx.doi.org/10.4317/medoral.22817DOI Listing

Therapeutic efficacy of a human papillomavirus type 16 E7 bacterial exotoxin fusion protein adjuvanted with CpG or GPI-0100 in a preclinical mouse model for HPV-associated disease.

Vaccine 2019 Apr 19. Epub 2019 Apr 19.

TheVax Genetics Vaccine Co., Ltd, Irvine, CA 92618, USA.

Persistent human papillomavirus (HPV) infection is causally linked to the development of several human cancers, including cervical, vulvar, vaginal, anal, penile, and oropharyngeal cancers. To address the need for a therapeutic vaccine against HPV-associated diseases, here we test and compare the immunogenicity and therapeutic efficacy of a bacterial exotoxin fusion protein covalently linked to the HPV16 E7 oncoprotein adjuvanted with CpG or GPI-0100 in the C3.43 preclinical HPV16-transformed tumor model. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.04.043DOI Listing

Oral gargle-tumor biopsy human papillomavirus (HPV) agreement and associated factors among oropharyngeal squamous cell carcinoma (OPSCC) cases.

Oral Oncol 2019 May 3;92:85-91. Epub 2019 Apr 3.

Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, United States. Electronic address:

Objective: Assess oral gargle-tumor human papillomavirus (HPV) agreement among oropharyngeal squamous cell carcinoma (OPSCC) cases by several disease characteristics.

Materials And Methods: 171 treatment naïve OPSCC were enrolled 2014-2017. Tumors were categorized as early or late disease with early disease defined as T1-2 with no nodal involvement or at most a single ipsilateral positive node <3 cm. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.03.019DOI Listing

Significant association of PD-L1 expression with human papillomavirus positivity and its prognostic impact in oropharyngeal cancer.

Oral Oncol 2019 May 18;92:33-39. Epub 2019 Mar 18.

Central Clinical School, Faculty of Medicine and Health, The University of Sydney, NSW, Australia; Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, NSW, Australia; Melanoma Institute Australia, The University of Sydney, NSW, Australia.

Background: The programmed death pathway plays a role in persistent human papillomavirus (HPV) infection as well as in resistance to immune elimination during malignant progression. In this study, we examined PD-L1 expression by immunohistochemistry and tumour infiltrating lymphocytes (TIL) in 214 patients with oropharyngeal squamous cell cancer (OPSCC) to assess its clinical significance.

Results: HPV-positive OPSCC were significantly more likely to express PD-L1 than HPV-negative OPSCC (85. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.03.012DOI Listing

Cross-hybridization between HPV genotypes in the Linear Array Genotyping Test confirmed by Next-Generation Sequencing.

Diagn Pathol 2019 Apr 22;14(1):31. Epub 2019 Apr 22.

División de Inmunología, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Sierra Mojada No. 800, Col. Independencia, 44340, Guadalajara, Jalisco, Mexico.

Background: Linear Array Genotyping Test (LA) is one of the gold standards used for Human Papillomavirus (HPV) genotyping, however, since its launching in 2006, new HPV genotypes are still being characterized with the use of high specificity techniques such as Next-Generation Sequencing (NGS). Derived from a previous study of the IMSS Research Network on HPV, which suggested that there might be cross-reaction of some HPV genotypes in the LA test, the aim of this study was to elucidate this point.

Methods: Double stranded L1 fragments (gBlocks) from different HPVs were used to perform LA test, additionally, 14 HPV83+ and 26 HPV84+ cervical samples determined with LA, were individually genotyped by NGS. Read More

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http://dx.doi.org/10.1186/s13000-019-0808-2DOI Listing

Decorin Expression in Human Vulva Carcinoma: Oncosuppressive Effect of Decorin cDNA Transduction on Carcinoma Cells.

J Histochem Cytochem 2019 Apr 22:22155419845373. Epub 2019 Apr 22.

Medical Biochemistry and Genetics, Institute of Biomedicine, University of Turku, Turku, Finland.

The extracellular matrix proteoglycan decorin is well-known for its oncosuppressive activity. Here, decorin expression was examined in human vulva carcinoma tissue samples and in primary and commercial cell lines representing this malignant disease. Furthermore, the effect of adenovirus-mediated decorin cDNA (Ad-DCN) transduction on the viability, proliferation, and the expression and activity of the epidermal growth factor receptor (ErbB/HER) family members of the cell lines were investigated. Read More

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http://dx.doi.org/10.1369/0022155419845373DOI Listing

Condyloma acuminata on the nipple and coronary sulcus of the penis: A case report.

Medicine (Baltimore) 2019 Apr;98(16):e15109

Infectious Disease Center, Peking University Ditan Teaching Hospital.

Rationale: Condyloma acuminatum (CA) is a benign tumor primarily caused by infection with human papillomavirus (HPV) type-6 or type-11, lesions of which are most frequently found on the genital and perianal squamous mucosa and skin. CA outside the genitals is not common.

Patient Concerns: A 29-year-old male presented with lesions on the left nipple and coronary sulcus after heterosexual contact. Read More

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http://Insights.ovid.com/crossref?an=00005792-201904190-0001
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http://dx.doi.org/10.1097/MD.0000000000015109DOI Listing
April 2019
3 Reads

A History of Innovations in the Diagnosis and Treatment of Oral and Head and Neck Cancer.

J Dent Res 2019 May;98(5):489-497

4 Department of Pathology, University of Chicago, Chicago, IL, USA.

Historical records as far back as 3000 BCE show that oral and head and neck cancer was a disease process well known to Egyptian physicians. Luminaries such as Hippocrates, Galen, Pott, and Virchow were instrumental in shaping our understanding of the etiology and pathogenesis of cancer. During the 20th century, evidence-based medicine catalyzed the development of rigorous science-based diagnostic and treatment protocols. Read More

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http://dx.doi.org/10.1177/0022034519833645DOI Listing
May 2019
2 Reads

[Acceptability of human papilloma virus vaccine: parent survey].

Pan Afr Med J 2018 2;31:71. Epub 2018 Oct 2.

Service de Pédiatrie A, CHU Mohammed VI, Marrakech, Faculté de Médecine et de Pharmacie, Université Cadi Ayyad, Marrakech, Maroc.

This study aims to evaluate the extent of human papilloma virus vaccine awareness among parents of girls in vaccine age group, their acceptability of the vaccine and factors associated with refusal. We conducted a survey among parents of girls aged 8-15 years, followed-up for several diseases in the Department of Pediatrics at the University Hospital Mohamed VI in Marrakech, Morocco, on parents' profile, their awareness of cancer of the cervix, HPV and HPV vaccine, the acceptance of HPV vaccine for their daughters and the arguments related to refusal. Ninety six questionnaires were included in the analysis. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.71.15400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457735PMC
October 2018

Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study.

Infect Agent Cancer 2019 8;14. Epub 2019 Apr 8.

4Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Laboratoire de Virologie, and Faculté de Médecine Paris Descartes, Université Paris V, Paris Sorbonne Cité, Paris, France.

We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Laboratoire National de Biologie Clinique et de Santé Publique of Bangui, the capital city of the Central African Republic. One oropharyngeal squamous cell carcinoma sample was positive for HPV type 16. The overall HPV prevalence in HNC biopsies was 0. Read More

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http://dx.doi.org/10.1186/s13027-019-0225-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454762PMC

Incidence and clinical predictors of cystic squamous cell carcinoma metastases in lateral cervical cysts.

J Laryngol Otol 2019 Apr 22:1-6. Epub 2019 Apr 22.

Department of Otorhinolaryngology - Head and Neck Surgery,Medical Faculty,Comenius University in Bratislava,Slovakia.

Objective: This study aimed to determine the incidence of metastatic squamous cell carcinoma in patients with an isolated cervical cystic mass, and to describe the clinical features that might predict the origin of cystic tumours.

Method: Adult patients with isolated lateral cervical cystic masses who were scheduled for surgery from 1st January 2010 to 31st August 2016 in two tertiary care referral centres in Slovakia were analysed retrospectively.

Results: The incidence of cystic metastases in the whole cohort and in patients aged over 40 years were 9. Read More

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http://dx.doi.org/10.1017/S0022215119000823DOI Listing

[Effects of hnRNP E1 and both early genes E2 and E6 of HPV16 together with their interactions on cervical carcinogenesis].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Apr;40(4):466-470

Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.

To explore the effects of hnRNP E1 and both early genes E2 and E6 of HPV16 as well as their interactions in the progression of cervical carcinogenesis. Subjects of this study included 56 women with normal cervix (NC), 58 patients with low-grade cervical intraepithelial neoplasm (CINⅠ) and 50 patients with high-grade cervical intraepithelial neoplasm (CINⅡ/Ⅲ) who were all recruited from the 'Cervical Lesions Study Cohort Project' in Jiexiu of Shanxi province from June to September, 2014. Another 40 patients with cervical squamous cell carcinoma (SCC) were from the Shanxi Tumor Hospital during the same period. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.04.018DOI Listing

HPV vaccine, Twitter, and gay, bisexual and other men who have sex with men.

Health Promot Int 2019 Apr 21. Epub 2019 Apr 21.

Drexel University Dornsife School of Public Health, 3215 Market St., Philadelphia, PA 19104, USA.

This study aimed to quantify human papillomavirus (HPV) vaccine Twitter messaging addressing gay, bisexual and other men who have sex with men (GB+MSM) and describes messaging by vaccine sentiment (attitudes towards vaccine) and characteristics (topic of messaging). Between August 2014 and July 2015, we collected 193 379 HPV-related tweets and classified them by vaccine sentiment and characteristics. We analysed a subsample of tweets containing the terms 'gay', 'bisexual' and 'MSM' (N = 2306), and analysed distributions of sentiment and characteristics using chi-square. Read More

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http://dx.doi.org/10.1093/heapro/daz030DOI Listing

HPV-specific antibodies at the oral cavity up to 30 months after the start of vaccination with the quadrivalent HPV vaccine among mid-adult aged men.

Vaccine 2019 Apr 17. Epub 2019 Apr 17.

Center for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Background: HPV-16 and HPV-18 cause most oropharyngeal cancers, which are increasing in incidence among males. Although HPV vaccines are highly effective against a number of HPV-associated cancers, efficacy for oropharyngeal cancers has not yet been demonstrated. In addition, the level of antibodies required for protection against oral HPV infection is unknown. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.03.064DOI Listing

Infectious human papillomavirus virions in semen reduce clinical pregnancy rates in women undergoing intrauterine insemination.

Fertil Steril 2019 Apr 17. Epub 2019 Apr 17.

Genk Institute for Fertility Technology, ZOL Hospitals, Genk, Belgium; Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.

Objective: To study the influence of human papillomavirus (HPV) virions present in different sperm fractions of male partners of women undergoing IUI on fertility outcome.

Design: Prospective noninterventional multicenter study.

Setting: Inpatient hospital fertility centers. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2019.02.002DOI Listing

Radiation therapy dose de-escalation compared to standard dose radiation therapy in definitive treatment of HPV-positive oropharyngeal squamous cell carcinoma.

Radiother Oncol 2019 May 4;134:81-88. Epub 2019 Feb 4.

Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, United States. Electronic address:

Background: Despite existing evidence that human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) has a favorable prognosis compared to HPV-negative OPSCC, randomized studies have yet to report the effect of de-escalating radiation therapy (RT) dose for definitive treatment. The aim of this study was to assess the effectiveness of dose de-escalated RT (DDRT) vs. standard dose RT (SDRT) in patients with HPV-positive OPSCC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01678140193002
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http://dx.doi.org/10.1016/j.radonc.2019.01.016DOI Listing
May 2019
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Immunization of mice by the co-administration of codon-optimized HPV16 E7 and lL12 genes against HPV16-associated cervical cancer.

Microb Pathog 2019 Apr 17. Epub 2019 Apr 17.

Infectious Disease Research Center, Golestan University of Medical Sciences, Gorgan, Iran; Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. Electronic address:

Background: Various promising procedures have been used to improve the potency of DNA vaccines for the treatment of human papillomavirus type 16 (HPV16) infections. Interleukin-12 (IL12) is a powerful adjuvant that can contribute to T cell-mediated protection against many pathogens, specifically viruses. Considering the important role of T cell-mediated immunity in tumor clearance, the induction of these responses can help control the progression of tumors in animal models. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.028DOI Listing

Increasing incidence rates of oropharyngeal squamous cell carcinoma in Germany and significance of disease burden attributed to human papillomavirus.

Cancer Prev Res (Phila) 2019 Apr 19. Epub 2019 Apr 19.

Department of Otolaryngology, Head and Neck Surgery, University Hospital Cologne.

Increasing incidences of head and neck cancers and rising proportions of these associated with human papilloma virus (HPV), especially in the oropharynx, have been reported in international studies. So far, the trends and contribution of HPV to the number of newly diagnosed cases of oropharyngeal squamous cell carcinomas (OPSCC) in Germany are uncertain. We investigated HPV association and incidence rates in a cohort of consecutively included patients with OPSCC in Giessen 2000-2017, and compared our results with regional (Giessen and the federal state of Hesse), national (Germany) and international (USA) databases. Read More

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http://cancerpreventionresearch.aacrjournals.org/lookup/doi/
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http://dx.doi.org/10.1158/1940-6207.CAPR-19-0098DOI Listing
April 2019
1 Read

Innervation of cervical carcinoma is mediated by cancer-derived exosomes.

Gynecol Oncol 2019 Apr 16. Epub 2019 Apr 16.

Sanford Research, Cancer Biology and Immunotherapy Group, 2301 East 60th St north, Sioux Falls, SD 57104, USA. Electronic address:

Objective: Recently, our laboratory identified sensory innervation within head and neck squamous cell carcinomas (HNSCCs) and subsequently defined a mechanism whereby HNSCCs promote their own innervation via the release of exosomes that stimulate neurite outgrowth. Interestingly, we noted that exosomes from human papillomavirus (HPV)-positive cell lines were more effective at promoting neurite outgrowth than those from HPV-negative cell lines. As nearly all cervical tumors are HPV-positive, we hypothesized that these findings would extend to cervical cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193114
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http://dx.doi.org/10.1016/j.ygyno.2019.04.651DOI Listing
April 2019
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The maintenance of an oral epithelial barrier.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, No. 14, Sec. 3, Renminnan Road, Chengdu, Sichuan 610041, China. Electronic address:

Oral epithelial barrier consists of closely controlled structure of the stratified squamous epithelium, which is the gateway to human bodies and encounters a huge burden of microbial, airborne and dietary antigens, as well as masticatory damage. Once this barrier is destroyed, it will trigger bone loss, tissue damage and microbial dysbiosis and lead to diseases, such as periodontitis, oral mucosal diseases and oral cancer. Recently, increasing evidences showed that different factors including microorganism, saliva, proteins and immune components have been considered to play a critical role in the disruption of oral epithelial barrier. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193028
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http://dx.doi.org/10.1016/j.lfs.2019.04.029DOI Listing
April 2019
1 Read

What is needed now for successful scale-up of screening?

Papillomavirus Res 2019 Apr 16;7:173-175. Epub 2019 Apr 16.

PATH, Seattle, USA.

Effective screening for pre-cancerous lesions of the cervix is the only protective intervention that can be offered to women that have not had the opportunity to be vaccinated. Elimination goals are being developed so that by 2030, 70% of women aged 35-45 years should have been screened at least once in a lifetime and 90% of all detected lesions should have been treated. These goals focus on a substantial reduction of cervical cancer burden in low- and middle-income countries (LMICs). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058521193003
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http://dx.doi.org/10.1016/j.pvr.2019.04.011DOI Listing
April 2019
1 Read

Trends in cervical cancer incidence rates by age, race/ethnicity, histological subtype, and stage at diagnosis in the United States.

Prev Med 2019 Apr 16. Epub 2019 Apr 16.

Surveillance and Health Services Research, American Cancer Society, Atlanta, GA, United States of America.

Recent trends of cervical cancer incidence by histology and age in the United States (U.S.) have not been reported. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.04.010DOI Listing

E6 proteins from high-risk HPV, low-risk HPV, and animal papillomaviruses activate the Wnt/β-catenin pathway through E6AP-dependent degradation of NHERF1.

PLoS Pathog 2019 Apr 19;15(4):e1007575. Epub 2019 Apr 19.

Department of Pathology, University of Virginia, Charlottesville, Virginia, United States of America.

High-risk human papillomavirus (HPV) E6 proteins associate with the cellular ubiquitin ligase E6-Associated Protein (E6AP), and then recruit both p53 and certain cellular PDZ proteins for ubiquitination and degradation by the proteasome. Low-risk HPV E6 proteins also associate with E6AP, yet fail to recruit p53 or PDZ proteins; their E6AP-dependent targets have so far been uncharacterized. We found a cellular PDZ protein called Na+/H+ Exchanger Regulatory Factor 1 (NHERF1) is targeted for degradation by both high and low-risk HPV E6 proteins as well as E6 proteins from diverse non-primate mammalian species. Read More

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http://dx.plos.org/10.1371/journal.ppat.1007575
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http://dx.doi.org/10.1371/journal.ppat.1007575DOI Listing
April 2019
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The Potential Role of Medicinal Mushrooms in the Prevention and Treatment of Gynecological Cancers: A Review.

Int J Med Mushrooms 2019 ;21(3):225-235

Department of Earth and Marine Sciences, University of Palermo, Bldg. 16, Viale delle Scienze, I-90128 Palermo, Italy.

A review of scientific information about the potential role of medicinal mushrooms in the prevention and treatment of gynecological cancers, human immunodeficiency virus, and human papillomavirus infections is reported here. The results of in vivo and in vitro experiments on 16 different species of Basidiomycetes and three Ascomycetes, which possess chemopreventive potential and are effective in clinical application in combination with chemotherapy, are also discussed. Medicinal mushroom extracts confirm an evident efficacy on the reduction of tumor cell proliferation and side effects in patients with gynecological tumors who are undergoing chemotherapy treatments. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030289DOI Listing
January 2019

Bowenoid papulosis unveiling a rare cause of immunosuppression.

Int J STD AIDS 2019 Apr 4;30(5):522-525. Epub 2019 Feb 4.

Department of Dermatology & Venereology, Govt. Medical College, Thrissur, Kerala.

Bowenoid papulosis (BP) is a premalignant condition usually caused by oncogenic types of human papillomavirus (HPV) presenting clinically as warty genital papules. Adult T-cell leukaemia-lymphoma (ATLL) is a peripheral T-cell leukaemia-lymphoma caused by the retrovirus, human T-cell lymphotropic virus 1 (HTLV-1). We report a case of BP initially mistaken as genital warts; on detailed evaluation the patient had features of chronic immunosuppression. Read More

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http://dx.doi.org/10.1177/0956462418813057DOI Listing
April 2019
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Comparison of urine, self-collected vaginal swab, and cervical swab samples for detecting human papillomavirus (HPV) with Roche Cobas HPV, Anyplex II HPV, and RealTime HR-S HPV assay.

J Virol Methods 2019 Apr 15;269:77-82. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, Korea University Guro Hospital, College of Medicine, Korea University, Seoul, Republic of Korea. Electronic address:

Background: Human papillomavirus (HPV) is well established as the main cause of cervical cancer. Non-invasive self-collected urine and vaginal sampling have the potential advantage of increasing patient compliance with cervical cancer screening.

Methods: Self-collected vaginal and urine samples and clinician-collected cervical samples were collected from 101 patients, including 84 patients with high grade squamous intraepithelial lesion and 17 patients with benign ovarian disease. Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.04.012DOI Listing
April 2019
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1.883 Impact Factor

Unusual prevalence of high-risk genotypes of human papillomavirus in a group of women with neoplastic lesions and cervical cancer from Central Mexico.

PLoS One 2019 18;14(4):e0215222. Epub 2019 Apr 18.

Department of Medicine, Center for Health Sciences, Autonomous University of Aguascalientes, Aguascalientes, México.

Human papillomavirus has been identified as a main etiological agent in the development of cervical cancer. HPV 16 and 18 have been reported the most widely prevalent genotypes worldwide. We conducted a study analyzing the prevalence of high and low risk human papillomavirus viral types in the Mexican state of Aguascalientes and neighboring cities in the states of Jalisco and Zacatecas in central Mexico. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215222PLOS
April 2019
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Estimated Number of Cases of High-Grade Cervical Lesions Diagnosed Among Women - United States, 2008 and 2016.

MMWR Morb Mortal Wkly Rep 2019 Apr 19;68(15):337-343. Epub 2019 Apr 19.

Human papillomavirus (HPV) causes approximately 30,000 cancers in the United States annually (1). HPV vaccination was introduced in 2006 to prevent HPV-associated cancers and diseases (1). Cervical cancer is the most common HPV-associated cancer in women (1). Read More

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http://dx.doi.org/10.15585/mmwr.mm6815a1DOI Listing

Inverted papilloma of the conjunctiva.

BMJ Open Ophthalmol 2019 28;4(1):e000193. Epub 2019 Feb 28.

Department of Pathology, Section for Eye Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Objective: The purpose of the present study is to describe the clinical and histopathological features of conjunctival inverted papilloma, to analyse for the presence of human papillomavirus (HPV), and to determine if HPV infection is associated with this type of tumour and its inverted growth pattern.

Methods And Analysis: Cases of conjunctival inverted papillomas were retrieved from the archives of the Department of Pathology, Rigshospitalet, Denmark. Patient records and pathology reports were reviewed. Read More

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http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2018-000
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http://dx.doi.org/10.1136/bmjophth-2018-000193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440594PMC
February 2019
1 Read

Syphilitic Cervicitis with Cervical Cancer Presenting as Oropharyngeal Syphilis: A Case Report.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of General Internal Medicine, Akashi Medical Center, Japan.

We herein report a patient with syphilitic cervicitis and cervical cancer presenting as oropharyngeal syphilis. A 31-year-old Japanese woman with a history of unprotected vaginal and oral sex visited our hospital with right submandibular adenomas and erythema in the extremities. The fornix uteri was red, with a nodule noted. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.2426-18DOI Listing
April 2019
2 Reads

Phosphorylation of HPV-16 L2 Contributes To Efficient Virus Infectious Entry.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

Tumour Virology Laboratory, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy

The Human Papillomavirus (HPV) capsid comprises two viral proteins, L1 and L2, with the L2 component being essential to ensure efficient endocytic transport of incoming viral genomes. Several studies have previously reported that L1 and L2 are post-translationally modified, but it is uncertain whether these modifications affect HPV infectious entry. Using a proteomic screen, we identified a highly conserved phospho-acceptor site on the HPV-16 and BPV-1 L2 proteins. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.00128-19
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http://dx.doi.org/10.1128/JVI.00128-19DOI Listing
April 2019
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Whole-Genome Analysis of Human Papillomavirus Type 16 Prevalent in Japanese Women with or without Cervical Lesions.

Viruses 2019 Apr 16;11(4). Epub 2019 Apr 16.

Pathogen Genomics Center, National Institute of Infectious Diseases, Musashi-murayama, Tokyo 208-0011, Japan.

Recent large-scale genomics studies of human papillomaviruses (HPVs) have shown a high level of genomic variability of HPV16, the most prevalent genotype in HPV-associated malignancies, and provided new insights into the biological and clinical relevance of its genetic variations in cervical cancer development. Here, we performed deep sequencing analyses of the viral genome to explore genetic variations of HPV16 that are prevalent in Japan. A total of 100 complete genome sequences of HPV16 were determined from cervical specimens collected from Japanese women with cervical intraepithelial neoplasia and invasive cervical cancer, or without cervical malignancies. Read More

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https://www.mdpi.com/1999-4915/11/4/350
Publisher Site
http://dx.doi.org/10.3390/v11040350DOI Listing
April 2019
3 Reads

Trends and Characteristics Associated with HPV Vaccination Uptake Among Men Who Have Sex with Men in the United States, 2014 - 2017.

Sex Transm Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of Epidemiology, Rollins School of Public Health, Emory University; Atlanta, GA.

Background: Human papillomavirus (HPV) and HPV-associated cancer rates are high among men who have sex with men (MSM). The US Advisory Committee on Immunization Practices (ACIP) recommends HPV vaccination for all MSM through age 26. We examined trends in HPV vaccine uptake among young US MSM between 2014-2017. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001008DOI Listing

A Short Report: Parents HPV Vaccine Knowledge in Rural South Florida.

Hum Vaccin Immunother 2019 Apr 17. Epub 2019 Apr 17.

a Nicole Wertheim College of Nursing and Health Sciences , Florida International University , 11200 SW 8th Avenue, AHC 3 520 A, Miami , Florida 33199.

An exploratory pilot descriptive research study was conducted in the rural counties of Hendry and Glades Florida exploring parental knowledge and hesitancy of HPV vaccination. Participants included parents/caregivers with children ages 9 to 13; using quantitative methods, we evaluated knowledge, feelings, and beliefs toward HPV vaccination including vaccination prevalence and correlates among participating parents/caregivers. Our measures included the Parental HPV Survey with a Cronbach alpha of . Read More

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https://www.tandfonline.com/doi/full/10.1080/21645515.2019.1
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http://dx.doi.org/10.1080/21645515.2019.1600986DOI Listing
April 2019
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Feasibility, Acceptability, and Accuracy of vaginal Self-Sampling for Screening Human Papillomavirus Types in Women from Rural Areas in Senegal.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Aix Marseille Université, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France.

Vaginal self-sampling and human papillomavirus (HPV) DNA testing can be useful tools for women with limited access to health care living in sub-Saharan Africa. To assess the feasibility and acceptability of vaginal self-sampling and high-risk HPV prevalence in two villages of central Senegal, women were asked to self-sample vaginal swabs for HPV detection in May, 2016. Vaginal swabs were collected from 133 women and were tested for HPV genotyping. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.19-0045
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http://dx.doi.org/10.4269/ajtmh.19-0045DOI Listing
April 2019
2 Reads

HPV-vaccination and cancer cervical screening in 53 WHO European Countries: An update on prevention programs according to income level.

Cancer Med 2019 Apr 16. Epub 2019 Apr 16.

Local Health Unit, Teramo, Italy.

Human papillomavirus (HPV) is the most common sexually transmitted disease in the world. The aim of our study is to describe the differences in HPV-vaccination coverage and screening programs in WHO European Countries notably according to income levels. Multiple correspondence analysis was applied to examine the association among the following variables: Gross National Income (GNI) levels (Lower-Middle Income, LMI; Upper-Middle Income, UMI; and High Income, HI); type of CC screening program (coverage; opportunistic/organized); vaccination payment policies (free or partial or total charge); mortality rates/100 000 (≤3; >3-6; >6-9; >9); incidence rates/100 000 (≤7; >7-15; >15-21; >21). Read More

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http://dx.doi.org/10.1002/cam4.2048DOI Listing

Transplant Recipients and Anal Neoplasia Study: Design, Methods, and Participant Characteristics of a Prevalence Study.

Transplant Direct 2019 Apr 4;5(4):e434. Epub 2019 Mar 4.

Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Kidney recipients have anal cancer rates 3 times higher than the general population in Australia and New Zealand. High-risk human papillomavirus (HPV) genotypes are implicated in the majority of anal cancers. Establishing the epidemiology of anal HPV infection and precursors of anal cancer in transplant recipient populations is 1 consideration in any potential screening program. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445652PMC

A Comparative Study for Selectivity of Micronuclei in Cervical Exfoliated Cells on Chronic Boron Effects.

J Cytol 2019 Apr-Jun;36(2):75-78

Department of Medical Biology, School of Medicine, Faculty of Health Sciences, Manisa Celal Bayar University, Manisa, Turkey.

Background: Cervical cancer is one of the most frequent malignancies in women. Micronucleus (MN) testing has gained popularity as a biomarker in early diagnosis of many types of cancer.

Aims: This study aims to investigate the role of MN testing on early detection of cervical cancer and the effect of boron exposure on cervical cells. Read More

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http://dx.doi.org/10.4103/JOC.JOC_185_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425774PMC
April 2019
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Supplemental testing is required to maintain control following a transition from Pap smear to HPV DNA testing for cervical screening: a mathematical modelling study.

Sex Transm Infect 2019 Apr 16. Epub 2019 Apr 16.

Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.

Objectives: Using mathematical modelling, we have previously shown that the prevalence of infection with (TV) is likely to increase in the general population in Australia with the transition from Pap smear-based cervical screening to human papillomavirus (HPV) DNA testing. Here we use the existing model to estimate the level of supplemental testing required to maintain TV control.

Methods: A compartmental mathematical model describing the transmission of TV in the general heterosexual population in Australia was used to evaluate the impact of a range of screening scenarios on TV prevalence over time following the transition to HPV DNA testing for cervical screening. Read More

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http://dx.doi.org/10.1136/sextrans-2018-053845DOI Listing

The SILVER Study. Efficacy Of Topical Nitric-Zinc Complex Solution In The Treatment Of Resistant Warts: A Post-Marketing Evaluation.

Dermatol Ther 2019 Apr 16:e12940. Epub 2019 Apr 16.

Department of Dermatology, Venereology and Allergology, Academic Teaching Department of Medical University Innsbruck, Central Hospital Bolzano/Bozen, Bolzano, Italy.

Background: The treatment of cutaneous viral warts caused by human papillomavirus (HPV) infection is often subject to local recurrence and a long clinical and treatment course. Our aim was to analyze real-life data on the treatment of difficult-to-treat warts from a multicenter post-marketing surveillance assessment on the efficacy, tolerability and safety of a commercially available nitric-zinc complex solution (NZCS).

Methods: Dermatologists from 14 Italian centers completed a questionnaire about their clinical experience on treatment of "difficult-to-treat" warts, which included plantar, periungual, anogenital wartsand warts on aesthetically sensitive areas. Read More

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http://dx.doi.org/10.1111/dth.12940DOI Listing
April 2019
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Study on the Significance of Folate Receptor-Mediated Staining Solution (FRD) Staining in Screening High Grade Cervical Lesions.

Med Sci Monit 2019 Apr 16;25:2792-2801. Epub 2019 Apr 16.

Department of Gynecology and Obstetrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland).

BACKGROUND The aim of this study was to investigate the significance of folate receptor-mediated staining solution (FRD) in examination of cervical lesions during gynecological examination. MATERIAL AND METHODS A total of 404 patients participated in this study. FRD staining was applied to screen high grade cervical lesions. Read More

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http://dx.doi.org/10.12659/MSM.911402DOI Listing
April 2019
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REBACIN® as a Non-invasive Clinical Intervention for High-Risk Human Papillomavirus Persistent Infection.

Int J Cancer 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynaecology, Peking Union Medical College Hospital, Beijing, China.

The development of highly sensitive HPV-genotyping tests has opened the possibility of treating HPV-infected women before high-grade lesions appear. The lack of efficient intervention for persistent high risk HPV infection necessitates the need for development of novel therapeutic strategy. Here we demonstrate that REBACIN®, a proprietary anti-viral biologics, has shown potent efficacy in the clearance of persistent HPV infections. Read More

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http://dx.doi.org/10.1002/ijc.32344DOI Listing
April 2019
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Use of community forums to increase knowledge of HPV and cervical cancer in African American communities.

J Community Health 2019 Apr 15. Epub 2019 Apr 15.

Division of Health Equities, Department of Population Sciences, City of Hope Medical Center, Duarte, CA, 91010, USA.

Cervical cancer adversely impacts African American communities. While disparities in incidence remain unclear, communities continue to use forums to increase cervical cancer education. The purpose of this paper is to examine the efficacy of using community forums to increase human papillomavirus vaccine (HPVV) and cervical cancer knowledge in African American communities. Read More

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http://dx.doi.org/10.1007/s10900-019-00665-2DOI Listing
April 2019
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Identification of key pathways and genes in nasopharyngeal carcinoma using bioinformatics analysis.

Oncol Lett 2019 May 8;17(5):4683-4694. Epub 2019 Mar 8.

Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210000, P.R. China.

Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck. The aim of the current study was to identify the key pathways and genes involved in NPC through bioinformatics analysis and to identify potential molecular mechanisms underlying NPC proliferation and progression. Three gene expression profiles (GSE12452, GSE34573 and GSE64634) were downloaded from the Gene Expression Omnibus database. Read More

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http://dx.doi.org/10.3892/ol.2019.10133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447945PMC
May 2019
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Reduction of cervical cancer incidence within a primary HPV screening pilot project (WOLPHSCREEN) in Wolfsburg, Germany.

Br J Cancer 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Klinikum Wolfsburg, Wolfsburg, Germany.

Background: Randomised controlled trials showed human papillomavirus (HPV)-based screening leads to a significant reduction in cervical cancer incidence compared with cytology-based screening only.

Methods: Non-hysterectomised participants ≥30 years underwent co-testing with Papanicolaou (Pap) smear and HR-HPV testing (Hybrid Capture 2; HC2). Women with normal findings had their next screening round after 5 years, and HC2+ and Pap abnormal cases were immediately referred for colposcopy, while cases with discordant findings had repeat testing after 12 months with referral to colposcopy in cases with persistent positive findings. Read More

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http://www.nature.com/articles/s41416-019-0453-2
Publisher Site
http://dx.doi.org/10.1038/s41416-019-0453-2DOI Listing
April 2019
2 Reads

Unlocking the Potential of Saliva-Based Test to Detect HPV-16-Driven Oropharyngeal Cancer.

Cancers (Basel) 2019 Apr 3;11(4). Epub 2019 Apr 3.

The School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology and the Translational Research Institute, Queensland 4059, Australia.

The incidence of human papillomavirus (HPV)-positive oropharyngeal cancer (OPC) is rising in high-income countries, including Australia. Increasing evidence suggests that accurate HPV testing is pivotal for clinical decision making and treatment planning in these patients. Recently, the eighth edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) tumor-node-metastasis (TNM) staging system for OPC (based on the p16INK4a (p16) status) was proposed and has been implemented. Read More

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https://www.mdpi.com/2072-6694/11/4/473
Publisher Site
http://dx.doi.org/10.3390/cancers11040473DOI Listing
April 2019
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Battery Powered Portable Thermal Cycler for Continuous-Flow Polymerase Chain Reaction Diagnosis by Single Thermostatic Thermoelectric Cooler and Open-Loop Controller.

Authors:
Di Wu Wenming Wu

Sensors (Basel) 2019 Apr 3;19(7). Epub 2019 Apr 3.

Changchun Institute of Optics, Fine Mechanics and Physics (CIOMP), Chinese Academy of Sciences, Changchun 130000, China.

Temperature control is the most important and fundamental part of a polymerase chain reaction (PCR). To date, there have been several methods to realize the periodic heating and cooling of the thermal-cycler system for continuous-flow PCR reactions, and three of them were widely used: the thermo-cycled thermoelectric cooler (TEC), the heating block, and the thermostatic heater. In the present study, a new approach called open-loop controlled single thermostatic TEC was introduced to control the thermal cycle during the amplification process. Read More

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http://dx.doi.org/10.3390/s19071609DOI Listing
April 2019
4 Reads