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    p16/Ki-67 dual staining has a better accuracy than human papillomavirus (HPV) testing in women under 30 years old.
    Bosn J Basic Med Sci 2018 Jun 20. Epub 2018 Jun 20.
    Department of Obstetrics and Gynecology, University of Medicine and Pharmacy "Victor Babeş" Timişoara, Timișoara, Romania.
    Due to a high rate of transient human papillomavirus (HPV) infection, HPV genotyping has a low specificity for high-grade cervical lesions, especially in young women. p16/Ki-67 dual immunohistochemical staining can also be used for the detection of oncogenic changes in cervical cells. Our aim was to compare the performance of p16/Ki-67 dual staining and HPV genotyping in the detection of high-grade cervical lesions in patients with atypical squamous cells of undetermined significance (ASCUS)/low-grade squamous intraepithelial lesion (LSIL) on Pap smear. Read More

    The impact of environmental and behavioural cofactors on the development of cervical disorders in HR-HPV-infected women in Serbia.
    Epidemiol Infect 2018 Jun 20:1-10. Epub 2018 Jun 20.
    Institute of Microbiology and Immunology,Faculty of Medicine,University of Belgrade,Belgrade,Serbia.
    Persistent infection with one or more highly oncogenic human papillomaviruses (HPVs) or high-risk-HPV (HR-HPV) is necessary but not a sufficient aetiological agent for the development of cervical neoplasia. A number of viral, host, environmental and behavioural factors are suggested to be associated with the progression of cervical disorder. This study aimed to evaluate the impact of environmental and behavioural cofactors on the development of cervical disorders in HR-HPV-infected women in Serbia. Read More

    HPV Misconceptions Among College Students: The Role of Health Literacy.
    J Community Health 2018 Jun 19. Epub 2018 Jun 19.
    Alabama Research Institute on Aging, The University of Alabama, 207 Osband Hall, Tuscaloosa, AL, 35487-0315, USA.
    Human papillomavirus (HPV) is currently the most common sexually transmitted disease in the United States, with potentially serious health consequences, including cervical cancer. Young adults are particularly at risk of infection, but many remain unvaccinated. Low health literacy may contribute to poor knowledge of HPV and lack of vaccine uptake, and women living in the Southeastern United States are particularly at risk for lower vaccination rates and cervical cancer screening adherence. Read More

    PERFORMANCE OF SMARTPHONE-BASED DIGITAL IMAGES FOR CERVICAL CANCER SCREENING IN A LOW-RESOURCE CONTEXT.
    Int J Technol Assess Health Care 2018 Jun 20:1-6. Epub 2018 Jun 20.
    Geneva Foundation for Medical Education and Research.
    Objectives: Colposcopes are expensive, heavy, and need specialized technical service, which may outreach the capacity of low-resource settings. Our aim was to assess the performance of smartphone-based digital images for the detection of cervical intraepithelial neoplasia grade 2 or worse (CIN2+).

    Methods: Human papillomavirus (HPV)-positive women recruited through a cervical cancer screening campaign had VIA/VILI assessment (visual inspection after application of acetic acid/lugol's iodine). Read More

    [The relationship between viral infection and nasal polyps:A Meta-analysis].
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jun;32(12):910-916
    China Medical University,Liaoning Provincial Education Department, Shenyang,110001,China.
    The relationship between viral infection and the occurrence of nasal polyps was explored to help us understand the etiology and pathogenesis of nasal polyps, and to provide scientific basis for the prevention and treatment of nasal polyps through a Meta-analysis. By searching Pubmed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang Database, and VIP Database, time starts from database building until January 1, 2018, a comprehensive case-control study on the relationship between human papillomavirus, Epstein-Barr virus (EBV), respiratory virus infection and nasal polyps published at home and abroad has been conducted. At the same time, relevant literature references have been included and the full texts have been obtained. Read More

    Genital basal cell carcinoma, a different pathogenesis from sun-exposed basal cell carcinoma? A case-control study of 30 cases.
    J Cutan Pathol 2018 Jun 19. Epub 2018 Jun 19.
    Department of Dermatology, MacKay Memorial Hospital, Taipei, Taiwan.
    Background: Genital basal cell carcinoma (BCC) accounts for <1% of all BCCs. We aimed to elucidate the pathogenesis of genital BCC.

    Methods: We retrospectively evaluated cases of pathologically diagnosed genital BCC between 1990 and 2016 in an Asian tertiary referral center. Read More

    An Update on Cellular MicroRNA Expression in Human Papillomavirus-Associated Head and Neck Squamous Cell Carcinoma.
    Oncology 2018 Jun 19:1-9. Epub 2018 Jun 19.
    Department of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
    Squamous cell carcinoma of mucosal sites in the head and neck (HNSCC) is the sixth most common cause of cancer worldwide, and despite advances in conventional management, it still has significant morbidity and mortality associated with both diagnosis and treatment. Advances in our understanding of the biological mechanisms underlying this disease have demonstrated a significant difference between human papillomavirus (HPV)-associated, HPV and tobacco associated, and HPV-negative disease. It remains important to further elucidate the biologic and genetic differences between HPV-associated and tobacco-associated disease, with the aim of earlier diagnosis through screening, and advances in management including the development of novel therapeutic agents. Read More

    The Impact of the National HPV Vaccination Program in England Using the Bivalent HPV Vaccine: Surveillance of Type-Specific HPV in Young Females, 2010-2016.
    J Infect Dis 2018 Jun 18. Epub 2018 Jun 18.
    HIV and STI Department, Centre for Infectious Disease Surveillance and Control, London, United Kingdom.
    Background: The national human papillomavirus (HPV) immunization program was introduced in England in September 2008 using the bivalent vaccine.

    Methods: We collected residual vulva-vaginal swab specimens from 16 to 24-year-old women attending for chlamydia screening between 2010 and 2016 and tested for HPV DNA. We compared changes in type-specific (vaccine and nonvaccine) HPV prevalence over time and association with vaccination coverage. Read More

    Cost-effectiveness of cervical cancer screening in women living with HIV in South Africa: A mathematical modeling study.
    J Acquir Immune Defic Syndr 2018 Jun 15. Epub 2018 Jun 15.
    Harvard T.H. Chan School of Public Health, 718 Huntington Avenue, Boston, Massachusetts, USA.
    Background: Women with HIV face an increased risk of human papillomavirus (HPV) acquisition and persistence, cervical intraepithelial neoplasia, and invasive cervical cancer. Our objective was to determine the cost-effectiveness of different cervical cancer screening strategies among women with HIV in South Africa.

    Methods: We modified a mathematical model of HPV infection and cervical disease to reflect co-infection with HIV. Read More

    Progress in Vaccine-Preventable and Respiratory Infectious Diseases-First 10 Years of the CDC National Center for Immunization and Respiratory Diseases, 2006-2015.
    Emerg Infect Dis 2018 Jul;24(7):1178-1187
    The need for closer linkages between scientific and programmatic areas focused on addressing vaccine-preventable and acute respiratory infections led to establishment of the National Center for Immunization and Respiratory Diseases (NCIRD) at the Centers for Disease Control and Prevention. During its first 10 years (2006-2015), NCIRD worked with partners to improve preparedness and response to pandemic influenza and other emergent respiratory infections, provide an evidence base for addition of 7 newly recommended vaccines, and modernize vaccine distribution. Clinical tools were developed for improved conversations with parents, which helped sustain childhood immunization as a social norm. Read More

    Human papillomavirus genotypes in Pacific Islander cervical cancer patients.
    Gynecol Oncol Rep 2018 May 18;24:83-86. Epub 2018 Apr 18.
    Dept OBGYN, Tripler Army Medical Center, United States.
    Objective: The role of human papillomavirus (HPV) in the development of invasive cervical cancers is widely known. Few HPV studies have targeted geographically isolated regions. The objective of this study was to determine the HPV genotypes in cervical cancer patients from the Pacific Islands referred to Tripler Army Medical Center (TAMC). Read More

    Adenovirus based HPV L2 vaccine induces broad cross-reactive humoral immune responses.
    Vaccine 2018 Jun 15. Epub 2018 Jun 15.
    Janssen Vaccines and Prevention, Pharmaceutical Companies of Johnson and Johnson, Leiden, The Netherlands. Electronic address:
    Oncogenic high-risk human papillomavirus (HPV) infections cause a substantial number of genital and non-genital cancers worldwide. Approximately 70% of all cervical cancers are caused by the high-risk HPV16 and 18 types. The remaining 30% can be attributed to twelve other high-risk HPV-types. Read More

    Validation of a New Low-Cost, Methanol-Based Fixative for Cervical Cytology and Human Papillomavirus Detection.
    Acta Cytol 2018 Jun 18:1-4. Epub 2018 Jun 18.
    Laboratorio Genoa/LPCM, São Paulo, Brazil.
    Objective: To test the performance of a new fixative for pap smear collection for liquid-based cervical cytology, CellPreserv® and compare it with the commercially available, PreservCyt® used in the diagnosis and detection of human papillomavirus (HPV).

    Methods: Seven hundred twenty five women participated in this study after signing an informed consent. The specimens were collected using a traditional device, agitated in PBS, and equally divided in both fixatives. Read More

    Non-human papillomaviruses for gene delivery in vitro and in vivo.
    PLoS One 2018 18;13(6):e0198996. Epub 2018 Jun 18.
    Department of Immunology, Fraunhofer-Institute for Cell Therapy and Immunology IZI, Leipzig, Germany.
    Papillomavirus capsids are known to have the ability to package DNA plasmids and deliver them both in vitro and in vivo. Of all known papillomavirus types, human papillomaviruses (HPVs) are by far the most intensely studied. Although HPVs work well as gene transfer vectors, their use is limited as most individuals are exposed to this virus either through a HPV vaccination or natural infection. Read More

    Is self-sampling to test for high-risk papillomavirus an acceptable option among women who have been treated for high-grade cervical intraepithelial neoplasia?
    PLoS One 2018 18;13(6):e0199038. Epub 2018 Jun 18.
    Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
    Objective: Self-sampling to test for high risk human papilloma virus (HPV) is becoming an increasingly important component of cervical cancer screening. The aim of this observational study is to examine how women treated for high-grade cervical intraepithelial neoplasia (CIN) view HPV self-sampling.

    Methods: Invited to participate in the present study were patients who had undergone treatment of high-grade CIN (grade 2 or higher) and were followed-up at 6-months at the Karolinska University Hospital, Stockholm. Read More

    Acceptability of HPV vaccines and associations with perceptions related to HPV and HPV vaccines among male baccalaureate students in Hong Kong.
    PLoS One 2018 18;13(6):e0198615. Epub 2018 Jun 18.
    School of Nursing, Hong Kong Polytechnic University, Hong Kong, China.
    Objectives: The highly infectious human papillomavirus (HPV) causes both genital warts and cervical cancer in women. In 2009, the prevalence of genital warts in Hong Kong was 203.7 per 100,000 person-years. Read More

    It's hard to reach the "hard-to-reach": the challenges of recruiting people who do not access preventative healthcare services into interview studies.
    Int J Qual Stud Health Well-being 2018 Dec;13(1):1479582
    a Research Department of Behavioural Science and Health , UCL , London , UK.
    In this article, we discuss the challenges faced in recruiting "hard-to-reach" groups for interview studies, specifically those who do not access preventative healthcare services. We do this by reflecting on the varying success of different recruitment methods we have used in two recent studies; one investigating ethnic disparities in human papillomavirus vaccination uptake and another exploring difference in cervical screening non-participation. Engaging new community groups to help with recruitment proved particularly difficult, as did recruiting online. Read More

    Topical therapies for the treatment of anal high-grade squamous intraepithelial lesions.
    Semin Colon Rectal Surg 2017 Jun 26;28(2):86-90. Epub 2017 Apr 26.
    Division of Infectious Diseases, Weill Cornell Medicine 53 W. 23 St. 6 Floor, New York, NY 10010, 212-746-7204 (phone), 212-746-7203 (fax).
    Anal cancer may be prevented by treating anal high-grade squamous intraepithelial lesions (HSIL). Ablative therapies are the most commonly used treatments, but they may not be appropriate for all patients including those with extensive HSIL or bleeding diastheses. Researchers have studied topical therapies for human papillomavirus related lesions including anal HSIL. Read More

    The epidemiology of oral human papillomavirus infection in healthy populations: A systematic review and meta-analysis.
    Oral Oncol 2018 Jul 21;82:91-99. Epub 2018 May 21.
    Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1445, Houston, TX 77030, USA. Electronic address:
    Human papillomavirus (HPV) is a potentially oncogenic sexually transmitted infection. As the incidence of oropharyngeal cancer (OPC) caused by oral HPV infections is rising, further investigation into the natural history of such infections is needed. This systematic review and meta-analysis aimed to synthesize data on the prevalence, incidence, clearance, and persistence of oral HPV infections in healthy individuals. Read More

    MicroRNA-155, -185 and -193b as biomarkers in human papillomavirus positive and negative tonsillar and base of tongue squamous cell carcinoma.
    Oral Oncol 2018 Jul 4;82:8-16. Epub 2018 May 4.
    Dept. of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden. Electronic address:
    Objective: Three-year disease-free survival (DFS) is 80% for human papillomavirus (HPV) positive tonsillar and base of tongue cancer (TSCC/BOTSCC) treated with radiotherapy alone, and today's intensified therapy does not improve prognosis. More markers are therefore needed to more accurately identify patients with good prognosis or in need of alternative therapy. Here, microRNAs (miRs) 155, 185 and 193b were examined as potential prognostic markers in TSCC/BOTSCC. Read More

    Dysfunction of HPV16-specific CD8+ T cells derived from oropharyngeal tumors is related to the expression of Tim-3 but not PD-1.
    Oral Oncol 2018 Jul 26;82:75-82. Epub 2018 May 26.
    Sotio, Jankovcova 1518/2, 170 00 Prague, Czech Republic. Electronic address:
    Background: Human papillomavirus (HPV) type 16 infection is one of the most important etiological agents of oropharyngeal squamous cell carcinoma. Patients with HPV-associated carcinomas of the head and neck were reported to have a better clinical outcome than patients with HPV-negative tumors. Because HPV16 E6 and E7 oncoproteins are highly immunogenic and constitutively expressed, HPV-specific T cell immunity may play the key role in improving the prognosis of these patients. Read More

    Human papillomavirus detection in gargles, tonsil brushings, and frozen tissues in cancer-free patients.
    Oral Oncol 2018 Jul 11;82:34-36. Epub 2018 May 11.
    Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine-Pierre et Marie Curie University-Paris VI and Tenon Hospital, Assistance Publique Hôpitaux De Paris, France. Electronic address:

    AJCC-8ed nodal staging does not predict outcomes in surgically managed HPV-associated oropharyngeal cancer.
    Oral Oncol 2018 Jul 28;82:138-143. Epub 2018 May 28.
    Department of Otolaryngology-Head and Neck Surgery, Philadelphia, PA, United States.
    Objective: To assess the pathological outcomes of surgically-managed human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (OPSCC) using the 8th Edition of the American Joint Committee on Cancer Staging Manual (AJCC-8ed).

    Materials And Methods: A retrospective review was conducted of 156 patients with previously untreated OPSCC who underwent primary TORS between March 2010 and February 2015 to evaluate the impact of the new AJCC-8ed pathologic staging system. Only patients who had complete pathologic staging with neck dissection and at least 2 years of follow-up records or disease recurrence within 2 years were included for analysis. Read More

    Smoking impact on HPV driven head and neck cancer's oncological outcomes?
    Oral Oncol 2018 Jul 26;82:131-137. Epub 2018 May 26.
    Department of Radiation Oncology, Gustave Roussy Cancer Campus, 114 rue Edouard Vaillant, Villejuif, France.
    Introduction: HPV-driven oropharyngeal cancer (OPC) patients have a better prognosis than their HPV-negative counterparts but several studies have suggested that among HPV-positive patients those with a smoking history had worse oncological outcomes. The aim of our study is to characterize the interplay between tobacco consumption, patient and disease characteristics, and disease control.

    Materials And Methods: All patients diagnosed with HPV-driven OPC and treated with curative intent between 2007 and 2009 and 2011-2016 at Gustave Roussy cancer center were included (n = 282). Read More

    Biomarkers for early identification of recurrences in HPV-driven oropharyngeal cancer.
    Oral Oncol 2018 Jul 21;82:108-114. Epub 2018 May 21.
    Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    One of the major concerns in oncology lies in the ability to detect recurrences at their earliest stage to increase the likelihood of cure following second line, or salvage, therapy. Although human papillomavirus (HPV)-driven oropharyngeal cancers have a good prognosis, 20-25% of patients will recur within 5 years of treatment and a significant portion will die from their disease. In recent years, great effort has been put toward evaluating the potential clinical utility of HPV-related biomarkers for early diagnosis of recurrent disease. Read More

    Determinants of human papillomavirus vaccine attitudes: an interview of Wisconsin parents.
    BMC Public Health 2018 Jun 15;18(1):746. Epub 2018 Jun 15.
    National Farm Medicine Center, Marshfield Clinic Research Institute, 1000 North Oak Ave, Marshfield, WI, 54449, USA.
    Background: Parental attitudes play a key role in their decisions to vaccinate adolescents against the human papillomavirus (HPV). Little is known, however, about the formative experiences that shape parents' attitudes about the HPV vaccine.

    Methods: We conducted semi-structured interviews with 25 parents of 11-17 year old adolescents in Wisconsin who changed their HPV vaccine attitudes (per prior surveys) over one year. Read More

    Prevalence of cervical, oral, and anal human papillomavirus infection in women living with HIV in Denmark - The SHADE cohort study.
    J Clin Virol 2018 May 25;105:64-71. Epub 2018 May 25.
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark.
    Background: Women living with HIV (WLWH) have elevated risk of human papillomavirus (HPV) related cancers.

    Objectives: To assess prevalence, distribution and concordance of cervical, oral, and anal HPV infection, and predictors of oral and anal HPV in WLWH in Denmark.

    Study Design: WLWH followed in the Study on HIV, cervical Abnormalities and infections in women in Denmark (SHADE) were enrolled and examined for cervical, oral, and anal HPV infection. Read More

    Evaluation of self-collected vaginal specimens for the detection of high-risk HPV infection and the prediction of high-grade cervical intraepithelial lesions in a high-burden, low-resource setting.
    Clin Microbiol Infect 2018 Jun 12. Epub 2018 Jun 12.
    Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia; Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia.
    Objectives: To compare the performance of self-collected vaginal (V) specimens with clinician-collected cervical (C) specimens for detection of high-risk human papillomavirus (hrHPV) and cervical disease using the Cepheid Xpert HPV, Roche Cobas 4800 HPV, and Hologic Aptima HPV assays.

    Methods: Women aged 30-59 years (N=1005) were recruited at two clinics in Papua New Guinea, and provided specimens for testing at point-of-care using the Xpert HPV Test, and for subsequent testing using the Cobas HPV (n=981) and Aptima HPV (n=983) assays. Liquid-based cytology was performed on C specimens to predict underlying high-grade squamous intraepithelial lesions (HSIL). Read More

    Impact of Naturally Occurring Variation in the Human Papillomavirus (HPV) 58 Capsid Proteins on Recognition by Type-Specific Neutralizing Antibodies.
    J Infect Dis 2018 Jun 13. Epub 2018 Jun 13.
    Virus Reference Department, Public Health England, London, U.K.
    Background: Naturally-occurring variants of Human papillomavirus (HPV) 58 have been defined as lineages and sublineages but little is known about the impact of this diversity on protein function. We investigate the impact of variation within the major (L1) and minor (L2) capsid proteins of HPV58 on susceptibility to neutralizing antibodies.

    Methods: Pseudovirus (PsV) representing A1, A2, A3, B1, B2, C, D1 and D2 variants were evaluated for their susceptibility to antibodies elicited during natural infection, preclinical antisera generated against virus-like particles and monoclonal antibodies (MAbs). Read More

    [HPV - A different view on Head and Neck Cancer].
    Laryngorhinootologie 2018 Mar 22;97(S 01):S48-S113. Epub 2018 Mar 22.
    Klinik für HNO-Heilkunde, Kopf-/Halschirurgie, Plastische Operationen, Universitätsklinikum Gießen und Marburg GmbH, Standort Gießen.
    Head and neck cancer is the sixth most common cancer with over 500000 annually reported incident cases worldwide. Besides major risk factors tobacco and alcohol, oropharyngeal squamous cell carcinomas (OSCC) show increased association with human papillomavirus (HPV). HPV-associated and HPV-negative OSCC are 2 different entities regarding biological characteristics, therapeutic response, and patient prognosis. Read More

    Prevalence and Risk Factors for Genital Human Papillomavirus Infections Among Women in Southwest Nigeria.
    Arch Basic Appl Med 2018 Feb 4;6(1):105-112. Epub 2018 May 4.
    Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
    There is a great variation in the prevalence of cervical HPV infection worldwide with some of the highest rates being found in African women. Early onset of sexual activity (≤ 15 age), multiparity and sexual promiscuity have been recognized as some of the significant risk factors for HPV infection. In Nigeria, there is scarcity of data on the degree of relationship between these factors and the prevalence of HPV infection. Read More

    Barriers to HPV Vaccination Among Unvaccinated, Haitian American College Women.
    Health Equity 2018 1;2(1):90-97. Epub 2018 Jun 1.
    Florida International University, Miami, Florida.
    Haitian women residing in the United States are disproportionately affected by cervical cancer. Human papillomavirus (HPV) vaccine has been licensed in the United States since 2006. Vaccination rates are less than optimal overall, and the rates are particularly low among young black women. Read More

    Parents' Views on the Best and Worst Reasons for Guideline-Consistent HPV Vaccination.
    Cancer Epidemiol Biomarkers Prev 2018 Jun 14. Epub 2018 Jun 14.
    Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
    Human papillomavirus (HPV) vaccination could prevent most HPV-associated cancers, but few U.S. adolescents are vaccinated according to guidelines. Read More

    TOPical Imiquimod treatment of residual or recurrent cervical intraepithelial neoplasia (TOPIC-2 trial): a study protocol for a randomized controlled trial.
    BMC Cancer 2018 Jun 15;18(1):655. Epub 2018 Jun 15.
    Department of Obstetrics and Gynecology, Erasmus Medical Center Cancer Institute, Post box 2040, 3000, CA, Rotterdam, The Netherlands.
    Background: Cervical dysplasia (cervical intraepithelial neoplasia (CIN)) is caused by Human Papillomavirus (HPV) and is most common in women of reproductive age. Current treatment of moderate to severe CIN is surgical. This procedure has potential complications, such as haemorrhage, infection and preterm birth in subsequent pregnancies. Read More

    The Association between Sexually Transmitted Infections, Human Papillomavirus and Cervical Cytology Abnormalities among Women in Greece.
    Int J Infect Dis 2018 Jun 11. Epub 2018 Jun 11.
    4th Department of Internal Medicine, 'Attikon' University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece. Electronic address:
    Objectives: To investigate STIs diagnosis with HPV infection and the presence of cytological changes of the cervix in a cohort of sexually active women in Greece.

    Methods: Cervical cytology testing, molecular typing of HPV and other STIs was performed in 345 sexually active women aged between 18 and 45 years (33.2±7. Read More

    Development of a Vaginal Fast-Dissolving Insert Combining Griffithsin and Carrageenan for Potential Use Against Sexually Transmitted Infections.
    J Pharm Sci 2018 Jun 11. Epub 2018 Jun 11.
    Population Council, Center for Biomedical Research, New York, NY, USA.
    Precoital, on-demand topical microbicides to reduce a woman's risk of sexually transmitted infections have been in development for nearly three decades, but no product has been approved due to acceptability issues and poor adherence in clinical trials. We set out to develop a self-administered vaginal fast-dissolving insert (FDI) produced by freeze-drying that would deliver safe and effective amounts of the antiviral agents griffithsin (GRFT) and carrageenan (CG) and would have properties women and their partners find acceptable. We evaluated FDI physical criteria, attributes of the gel produced upon dissolving, and GRFT stability. Read More

    Expression of Markers of Müllerian Clear Cell Carcinoma in Primary Cervical and Vaginal Gastric-type Adenocarcinomas.
    Int J Gynecol Pathol 2018 Jun 12. Epub 2018 Jun 12.
    Department of Pathology, Box Hill Hospital, Melbourne, Vic., Australia (K.L.T.) Department of Clinical Pathology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China (R.W.-C.W.) Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK (W.G.M.).
    The incidence of cervical adenocarcinoma, both absolute and relative to squamous cell carcinoma, is increasing. Most cervical adenocarcinomas are human papillomavirus associated, although non-human papillomavirus-associated neoplasms exist; the latter include gastric-type adenocarcinoma (GAS) and clear cell carcinoma (CCC). Histologically, these 2 tumors may superficially resemble one other and although morphologic evaluation usually permits a correct diagnosis, immunohistochemistry may be required to resolve diagnostic uncertainty, especially in a small biopsy specimen. Read More

    A comparative study of two techniques in the treatment of condyloma acuminata.
    Ann Ital Chir 2018 Jun 14;7. Epub 2018 Jun 14.
    Objectives: Condyloma acuminata (CA) is mainly caused by human papillomavirus (HPV) types 6 and 11. Clinicians use many different methods to treat analcondyloma acuminate ( CA). In this study, we aimed to compare electrocautery ablation (ECA) and argon plasma coagulation (APC) techniques in terms of postoperative bleeding, pain, scar development, loss of sexual sensation, and recurrence rates. Read More

    Early synergistic interactions between the HPV16‑E7 oncoprotein and 17β-oestradiol for repressing the expression of Granzyme B in a cervical cancer model.
    Int J Oncol 2018 Jun 6. Epub 2018 Jun 6.
    Department of Genetics and Molecular Biology, Centre for Research and Advanced Studies of the National Polytechnic Institute, México City 07360, México.
    Although high-risk human papillomavirus (HR‑HPV) infection has a prominent role in the aetiology of cervical cancer (CC), sex steroid hormones may also be involved in this process; however, the cooperation between oestrogen and HR‑HPV in the early stages of cervical carcinogenesis is poorly understood. Since 17β-oestradiol (E2) and the HPV type 16‑E7 oncoprotein induce CC in transgenic mice, a microarray analysis was performed in the present study to generate global gene expression profiles from 2‑month‑old FVB (non‑transgenic) and K14E7 (transgenic) mice who were left untreated or were treated for 1 month with E2. Upregulation of cancer-related genes that have not been previously reported in the context of CC, including glycerophosphodiester phosphodiesterase domain containing 3, interleukin 1 receptor type II, natriuretic peptide type C, MGAT4 family member C, lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) and glucoside xylosyltransferase 2, was observed. Read More

    High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines.
    Oncotarget 2018 May 25;9(40):26064-26071. Epub 2018 May 25.
    Department of Otolaryngology - Head and Neck Surgery, London Health Sciences Centre, London, Ontario, Canada.
    Head and neck squamous cell carcinoma (HNSCC) is a common cancer diagnosis worldwide. Despite advances in treatment, HNSCC has very poor survival outcomes, emphasizing an ongoing need for development of improved therapeutic options. The distinct tumor characteristics of human papillomavirus (HPV)-positive . Read More

    Atypical Squamous Cells: Cytopathological Findings and Correlation with HPV Genotype and Histopathology.
    Acta Cytol 2018 Jun 13:1-7. Epub 2018 Jun 13.
    Department of Pathology, Federal University of Ceará, Fortaleza, Brazil.
    Objective: We aimed to assess potential associations between atypical squamous cell (ASC) subgroups: ASC-US (undetermined significance) and ASC-H (cannot exclude high-grade squamous intraepithelial lesion), regarding cytomorphological features, high-risk (HR) human papillomavirus (HPV) testing, and histological outcomes in a sample of Brazilian women.

    Study Design: Cross-sectional study which evaluated 1,346 liquid-based cytologies between January 2010 and July 2016 with ASC results. ASC-US and ASC-H were analyzed for frequency, diagnostic criteria, and cytological findings and compared with HR-HPV tests and histological outcomes. Read More

    Electrochemotherapy with cisplatin or bleomycin in head and neck squamous cell carcinoma: Improved effectiveness of cisplatin in HPV-positive tumors.
    Bioelectrochemistry 2018 Jun 6;123:248-254. Epub 2018 Jun 6.
    Department of Experimental Oncology, Institute of Oncology, Ljubljana, Zaloska 2, SI-1000 Ljubljana, Slovenia; Faculty of Health Sciences, University of Ljubljana, Zdravstvena pot 5, SI-1000 Ljubljana, Slovenia. Electronic address:
    Human papillomavirus (HPV) is an important etiological factor in head and neck squamous cell carcinomas (SCCs). Standard treatment of HPV-positive tumors with platinum-based radio(chemo)therapy results in a better outcome than in HPV-negative tumors. Electrochemotherapy is becoming an increasingly recognized mode of treatment in different cancers; thus, its use in the management of head and neck SCC is of considerable interest. Read More

    Ultrahigh-resolution optical coherence microscopy accurately classifies precancerous and cancerous human cervix free of labeling.
    Theranostics 2018 30;8(11):3099-3110. Epub 2018 Apr 30.
    Department of Electrical and Computer Engineering, Lehigh University, Bethlehem PA 18015, USA.
    Cervical cancer remains the fourth most common cause of cancer worldwide and the third leading cause of cancer deaths for women in developing countries. Traditional screening tools, such as human papillomavirus and Pap tests, cannot provide results in real-time and cannot localize suspicious regions. Colposcopy-directed biopsies are invasive in nature and only a few sites of the cervix may be chosen for investigation. Read More

    Role of the DNA Damage Response in Human Papillomavirus RNA Splicing and Polyadenylation.
    Int J Mol Sci 2018 Jun 12;19(6). Epub 2018 Jun 12.
    Department of Laboratory Medicine, Lund University, 221 84 Lund, Sweden.
    Human papillomaviruses (HPVs) have evolved to use the DNA repair machinery to replicate its DNA genome in differentiated cells. HPV activates the DNA damage response (DDR) in infected cells. Cellular DDR factors are recruited to the HPV DNA genome and position the cellular DNA polymerase on the HPV DNA and progeny genomes are synthesized. Read More

    The HPV E2 Transcriptional Transactivation Protein Stimulates Cellular DNA Polymerase Epsilon.
    Viruses 2018 06 12;10(6). Epub 2018 Jun 12.
    Departments of Microbiology & Immunology and Biochemistry, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA.
    The papillomavirus (PV) protein E2 is one of only two proteins required for viral DNA replication. E2 is the viral transcriptional regulator/activation protein as well as the initiator of viral DNA replication. E2 is known to interact with various cellular DNA replication proteins, including the PV E1 protein, the cellular ssDNA binding complex (RPA), and topoisomerase I. Read More

    Community-based HPV self-collection versus visual inspection with acetic acid in Uganda: a cost-effectiveness analysis of the ASPIRE trial.
    BMJ Open 2018 Jun 12;8(6):e020484. Epub 2018 Jun 12.
    Department of Health Policy and Management, Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    Background: Cervical cancer is the leading cause of cancer death for women in Uganda, despite the potential for prevention through organised screening. Community-based self-collected human papillomavirus (HPV) testing has been proposed to reduce barriers to screening.

    Objective: Our objective was to evaluate the cost-effectiveness of the Advances in Screening and Prevention of Reproductive Cancers (ASPIRE) trial, conducted in Kisenyi, Uganda in April 2014 (n=500). Read More

    Characterization of a new genotype of Betapapillomavirus HPV 17 through L1, E7, E7 and LCR sequences.
    Acta Virol 2018 ;62(2):172-178
    Human papillomavirus (HPV) exhibits epithelial and mucosal tropism. HPV type 17 belongs to the Betapapillomavirus genus and molecular cloning experiments have identified two subtypes (17a and 17b) isolated from epidermodysplasia verruciformis (EV). HPV subtypes are characterized by dissimilarities from 2 to 10% at the nucleotide level from their referenced HPV. Read More

    A compact, low-cost, quantitative and multiplexed fluorescence detection platform for point-of-care applications.
    Biosens Bioelectron 2018 Apr 4;117:153-160. Epub 2018 Apr 4.
    School of Electrical, Computer and Energy Engineering at Arizona State University, Suite 334, Goldwater Center, Tempe, AZ 85287, USA. Electronic address:
    An effective method of combating infectious diseases is the deployment of hand-held devices at the point-of-care (POC) for screening or self-monitoring applications. There is a need for very sensitive, low-cost and quantitative diagnostic devices. In this study, we present a low-cost, multiplexed fluorescence detection platform that has a high sensitivity and wide dynamic range. Read More

    Papillomavirus Infection in Humans and Dromedary Camels in Eastern Sudan.
    Vector Borne Zoonotic Dis 2018 Jun 12. Epub 2018 Jun 12.
    4 Department of Pathology, Faculty of Veterinary Medicine, University of Khartoum , Khartoum North, Sudan .
    Cases of wart-like lesions in humans and dromedary camels occurred in eastern Sudan in 2015 were described. Involvement of papillomavirus (PV) in causing these cases was affirmed by PCR and immunoperoxidase test. Mostly, the lesions were observed on the skin of the chest and forearms in addition to lips and mandible. Read More

    CIP2A facilitates the G1/S cell cycle transition via B-Myb in human papillomavirus 16 oncoprotein E6-expressing cells.
    J Cell Mol Med 2018 Jun 12. Epub 2018 Jun 12.
    Department of Microbiology and Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
    Infection with high-risk human papillomaviruses (HR-HPVs, including HPV-16, HPV-18, HPV-31) plays a central aetiologic role in the development of cervical carcinoma. The transforming properties of HR-HPVs mainly reside in viral oncoproteins E6 and E7. E6 protein degrades the tumour suppressor p53 and abrogates cell cycle checkpoints. Read More

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