18,084,928 results match your criteria Human Movement Science [Journal]

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Sodium Chloride Aggravates Arthritis via Th17 Polarization.

Yonsei Med J 2019 Jan;60(1):88-97

Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Sodium chloride (NaCl) has been proposed as a driving factor in autoimmune diseases through the induction of pathogenic CD4 T helper cells that produce interleukin-17 (Th17 cells). This study investigated the effects of NaCl on inflammatory arthritis in mice and humans.

Materials And Methods: Collagen-induced arthritis (CIA) mice were fed a normal or high-salt diet , and clinical and histologic features of arthritis were evaluated. Read More

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January 2019

Up-Regulation of MiR-1915 Inhibits Proliferation, Invasion, and Migration of -Infected Gastric Cancer Cells via Targeting RAGE.

Yonsei Med J 2019 Jan;60(1):38-47

Department of Gastrointestinal Tumor, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Purpose: -infected gastric cancer (GC) is known to be a fatal malignant tumor, but the molecular mechanisms underlying its proliferation, invasion, and migration remain far from being completely understood. Our aim in this study was to explore miR-1915 expression and its molecular mechanisms in regulating proliferation, invasion, and migration of -infected GC cells.

Materials And Methods: Quantitative real-time PCR and western blot analysis were performed to determine miR-1915 and receptor for advanced glycation end product (RAGE) expression in -infected GC tissues and gastritis tissues, as well as human gastric mucosal cell line GES-1 and human GC cell lines SGC-7901 and MKN45. Read More

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January 2019
2 Reads

MiR-506 Promotes Natural Killer Cell Cytotoxicity against Human Hepatocellular Carcinoma Cells by Targeting STAT3.

Yonsei Med J 2019 Jan;60(1):22-29

Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Purpose: It is well documented that natural killer (NK) cytotoxicity against hepatocellular carcinoma (HCC) cells is impaired in HCC, which might account for the failure of anti-tumor immune response. miRNAs are considered as important regulators for the development and functions of NK cells. However, the entire role of miR-506 in NK cells remains far from being addressed. Read More

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January 2019

Platelet-derived growth factor stabilises vascularisation in collagen-glycosaminoglycan scaffolds in vitro.

J Tissue Eng Regen Med 2018 Dec 16. Epub 2018 Dec 16.

Kearney Lab, Department of Anatomy, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland.

Collagen-glycosaminoglycan (CG) scaffolds have been widely developed for a range of regenerative medicine applications. To enhance their efficacy, CG scaffolds have previously been pre-vascularised in vitro using human endothelial cells and mesenchymal stromal cells (hMSC); however, at later time-points, a regression of vascularisation is observed. This is undesirable for longer pre-culture periods (e. Read More

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December 2018

Behavioral and Imaging Studies of Infant Artificial Grammar Learning.

Top Cogn Sci 2018 Dec 15. Epub 2018 Dec 15.

Department of Psychology, University of Arizona.

Artificial grammar learning (AGL) paradigms have proven to be productive and useful to investigate how young infants break into the grammar of their native language(s). The question of when infants first show the ability to learn abstract grammatical rules has been central to theoretical debates about the innate vs. learned nature of grammar. Read More

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December 2018
1 Read

Elizabethkingia miricola infection in Chinese spiny frog (Quasipaa spinosa).

Transbound Emerg Dis 2018 Dec 16. Epub 2018 Dec 16.

College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Sichuan, 611130, China.

Elizabethkingia miricola is a Gram-negative rod which has been incriminated in severe infections in humans. Recently, a serious infectious disease was identified in Chinese spiny frogs (Quasipaa spinosa), in the Sichuan Province of China; the disease was characterized by corneal opacity, the presence of ascites, and neurologic symptoms. A Gram-negative bacillus was isolated from the liver, spleen, and kidney of the diseased frogs. Read More

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December 2018

Arousal from hibernation and reactivation of Eptesicus fuscus gammaherpesvirus (EfHV) in big brown bats.

Transbound Emerg Dis 2018 Dec 16. Epub 2018 Dec 16.

Department of Microbiology, Western College of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Many viruses that cause serious and often fatal disease in humans have spilled over from bats. Recent evidence suggests that stress may enhance virus shedding by bats increasing the possibility of transmission to other species. To understand the reasons for spillover it is therefore important to determine the molecular pathways that link stress to virus reactivation and shedding in bats. Read More

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December 2018

Orf virus infection of human keratinocytes and dermal fibroblasts: limited virus detection and interference with intercellular adhesion molecule-1 up-regulation.

Exp Dermatol 2018 Dec 15. Epub 2018 Dec 15.

Institute of Immunology/Molecular Pathogenesis, Center for Biotechnology and Biomedicine, College of Veterinary Medicine, Leipzig University, Leipzig, Germany.

Orf virus (Parapoxvirus ovis, ORFV) is a dermatotropic virus causing pustular dermatitis in small ruminants and humans. We analyzed isolated human primary keratinocytes (KC) and dermal fibroblasts (FB) for cell death and virus replication by infection with a patient-derived ORFV isolate. ORFV infection was associated with rapid induction of cell death in KC allowing for considerable virus removal. Read More

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December 2018
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Origin site-based staging system of sinonasal inverted papilloma for application to endoscopic sinus surgery.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.

Background: We aimed to assess the recurrence risk of sinonasal inverted papillomas (SNIPs), based on a staging system developed according to the originating site of SNIP.

Methods: A total of 200 patients with SNIP were enrolled, and a staging system was developed based on the originating sites and corresponding recurrence rates of tumor in the patients. In the verification phase, 675 patients with SNIPs were enrolled as above, and the originating sites of the SNIPs were confirmed by an endoscopic sinus surgery. Read More

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December 2018

Three-Dimensional Printing in Anatomy Education:Assessing Potential Ethical Dimensions.

Authors:
D Gareth Jones

Anat Sci Educ 2018 Dec 15. Epub 2018 Dec 15.

Department of Anatomy, University of Otago, Dunedin, New Zealand.

New technological developments have frequently had major consequences for anatomy education, and have raised ethical queries for anatomy educators. The advent of three-dimensional (3D) printing of human material is showing considerable promise as an educational tool that fits alongside cadaveric dissection, plastination, computer simulation, and anatomical models and images. At first glance its ethical implications appear minimal, and yet the more extensive ethical implications around clinical bioprinting suggest that a cautious approach to 3D printing in the dissecting room is in order. Read More

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December 2018

Shoulder symptoms and quality of life impact of limited neck dissection after de-intensified chemoradiotherapy: Secondary analysis of two prospective trials.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Radiation Oncology, University of North Carolina Hospitals, Chapel Hill, North Carolina.

Background: We investigated the quality of life (QOL) impact of post-radiation therapy (RT) superselective/selective neck dissection after de-intensified chemoradiation for human papillomavirus-associated oropharynx cancer.

Methods: A total of 147 patients received 60 Gy and weekly low-dose cisplatin on two phase 2 trials with planned post-RT neck dissection or surveillance positron emission tomography with neck dissection reserved for salvage. UW-QOL Shoulder Score, EORTC H&N-35, and EAT-10 were assessed. Read More

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December 2018
1 Read

Thalamic Morphometric Changes Induced by First-Person Action Videogame Training.

Eur J Neurosci 2018 Dec 16. Epub 2018 Dec 16.

Siena Brain Investigation & Neuromodulation Lab (Si-BIN Lab), Department of Medicine, Surgery and Neuroscience, Neurology and Clinical Neurophysiology Section, University of Siena, Italy.

Cross-sectional data suggest videogaming as promoting modifications in perceptual and cognitive skills of players, as well as inducing structural brain changes. However, whether such changes are both possible after a systematic gaming exposure, and last beyond the training period, is not known. Here we originally quantified immediate and long-lasting cognitive and morphometric impact of a systematic gaming experience on a first-person shooter (FPS) game. Read More

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December 2018
1 Read

CXCR4 enhances cisplatin resistance of human tongue squamous cell carcinoma.

J Oral Pathol Med 2018 Dec 16. Epub 2018 Dec 16.

Department of Stomatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.

Background: The chemokine receptor 4 (CXCR4) plays an important role in tumor progression. Overexpressed CXCR4 is associated with a poor prognosis of patient with head and neck squamous cell carcinomas. However, the correlation between CXCR4 and chemotherapy resistance in tongue squamous cell carcinoma (TSCC) remains obscure. Read More

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December 2018

House dust mite drives pro-inflammatory eicosanoid reprogramming and macrophage effector functions.

Allergy 2018 Dec 16. Epub 2018 Dec 16.

Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, member of the German Center for Lung Research, 80802, Munich, Germany.

Background: Eicosanoid lipid mediators play key roles in type 2 immune responses, e.g. in allergy and asthma. Read More

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December 2018

Immunohistochemical study of four fish tumors.

J Aquat Anim Health 2018 Dec 16. Epub 2018 Dec 16.

Dept. of Veterinary Sciences, Polo Universitario dell'Annunziata, University of Messina, 98168, Messina, Italy.

The present study supports the usefulness of ancillary techniques such as immunohistochemistry as a valid diagnostic tool in the field of fish oncology. The immunohistochemical patterns observed in four neoplasms, in four individual teleosts belonging to different species are here described. Cytokeratin, vimentin, actin, S-100, calretinin, and melan A antibodies were used. Read More

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December 2018

Overcoming bioethical, legal, and hereditary barriers to mitochondrial replacement therapy in the USA.

J Assist Reprod Genet 2018 Dec 15. Epub 2018 Dec 15.

Exergen Corporation, Watertown, MA, USA.

The purpose of the paper is to explore novel means to overcome the controversial ban in the USA against mitochondrial replacement therapy, a form of IVF, with the added step of replacing a woman's diseased mutated mitochondria with a donor's healthy mitochondria to prevent debilitating and often fatal mitochondrial diseases. Long proven effective in non-human species, MRT recently performed in Mexico resulted in the birth of a healthy baby boy. We explore the ethics of the ban, the concerns over hereditability of mitochondrial disease and its mathematical basis, the overlooked role of Mitochondrial Eve, the financial burden of mitochondrial diseases for taxpayers, and a woman's reproductive rights. Read More

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December 2018

Lipophilic statins inhibit growth and reduce invasiveness of human endometrial stromal cells.

J Assist Reprod Genet 2018 Dec 15. Epub 2018 Dec 15.

Division of Reproductive Endocrinology and Infertility, Department of Reproductive Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0633, USA.

Purpose: To compare effects of lipid-soluble statins (simvastatin, lovastatin, atorvastatin) and water-soluble statin (pravastatin) on growth and invasiveness of human endometrial stromal (HES) cells.

Methods: Endometrial biopsies were collected during the proliferative phase from five volunteers. HES cells were isolated and cultured in the absence or in the presence of simvastatin, lovastatin, atorvastatin, and pravastatin. Read More

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December 2018

Gut microbiome approaches to treat obesity in humans.

Appl Microbiol Biotechnol 2018 Dec 16. Epub 2018 Dec 16.

Department of Food and Nutrition, School of Pharmaceutical Sciences, State University of São Paulo (UNESP), Araraquara, SP, Brazil.

The rising worldwide prevalence of obesity has become a major concern having many implications for the public health and the economy. It is well known that many factors such as lifestyle, increased intake of foods high in fat and sugar and a host's genetic profile can lead to obesity. Besides these factors, recent studies have pointed to the gut microbiota composition as being responsible for the development of obesity. Read More

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December 2018

Oceanobacillus timonensis sp. nov. and Oceanobacillus senegalensis sp. nov., two new moderately halophilic, Gram-stain positive bacteria isolated from stools sample of healthy young Senegalese.

Antonie Van Leeuwenhoek 2018 Dec 15. Epub 2018 Dec 15.

Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France.

Oceanobacillus timonensis Marseille-P3532 (CSUR P3532, CCUG 70981) and Oceanobacillus senegalensis Marseille-P3587 (CSUR P3587, CCUG 70613), are the type strains of O. timonensis sp. nov. Read More

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December 2018

Tuftsin phosphorylcholine-a novel compound harnessing helminths to fight autoimmunity.

Immunol Res 2018 Dec 15. Epub 2018 Dec 15.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, affiliated with the Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.

The distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such are phosphorylcholine (PC) moieties which are a component of secreted products of helminths. PC has been broadly studied for its attenuating effects on the human immune system. Read More

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December 2018

Adsorption and in vitro release study of curcumin form polyethyleneglycol functionalized multi walled carbon nanotube: kinetic and isotherm study.

Daru 2018 Dec 15. Epub 2018 Dec 15.

Department of Food Science & Technology, Faculty of Food Industry and Agriculture, Standard Research Institute (SRI), Karaj, P.O. Box: 31745-139, Iran.

Polyethylene glycol functionalized with oxygenated multi-walled carbon nanotubes (O-PEG-MWCNTs) as an efficient nanomaterial for the in vitro adsorption/release of curcumin (CUR) anticancer agent. The synthesized material was morphologically characterized using scanning electron microscopy, Fourier transform infrared spectroscopy and transmission electron microscopy. In addition, the CUR adsorption process was assessed with kinetic and isotherm models fitting well with pseudo-second order and Langmuir isotherms. Read More

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December 2018

Voltammetric determination of levofloxacin using silver nanoparticles deposited on a thin nickel oxide porous film.

Mikrochim Acta 2018 Dec 15;186(1):21. Epub 2018 Dec 15.

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, People's Republic of China.

The authors describe a simplified chemical precipitation method and silver mirror reaction to synthesize a nanocomposite consiting of silver nanoparticles on a thin and porous nickel oxide film. Placed on a glassy carbon electrode (GCE), it allows for the determination of levofloxacin (LEV) via square wave voltammetry (SWV). Under optimal detection conditions, the voltammetric signal (typically measured at around 0. Read More

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December 2018

Autism in India: a case-control study to understand the association between socio-economic and environmental risk factors.

Acta Neurol Belg 2018 Dec 15. Epub 2018 Dec 15.

Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, 641 046, India.

Autism spectrum disorder is a neurodevelopmental disorder and the cause of autism is still unclear. The aim of this study was to investigate the association of socioeconomic, environmental, pregnancy and newborn-related risk factors among children with autism spectrum disorders. This was a population-based case-control study. Read More

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December 2018

Impact of large-scale tree planting in Yunnan Province, China, on the water supply balance in Southeast Asia.

Environ Monit Assess 2018 Dec 15;191(1):20. Epub 2018 Dec 15.

Chongqing College of Arts and Sciences, Chongqing, 402160, China.

Along with rapid economic development and population growth, anthropogenic disturbances to natural ecosystems increase the progressively worsening environmental problems in and around water resources, making the potential ecological risks more severe and unpredictable. In order to cope with the increasingly serious issues related to the ecological environment and poverty alleviation, the Government of Yunnan in Southwest China launched a large-scale afforestation campaign (plantation forestry) on the Yunnan-Guizhou Plateau, which is the main source of several major river systems in Southeast Asia. In this study, we use GIS to investigate the impacts of a large-scale afforestation on the water storage balance of Southeast Asia. Read More

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December 2018

TP53 inactivation and expression of methylation-associated proteins in gastric adenocarcinoma with enteroblastic differentiation.

Virchows Arch 2018 Dec 15. Epub 2018 Dec 15.

Department of Human Pathology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan.

Gastric adenocarcinoma with enteroblastic differentiation (GAED) is a rare variant of aggressive adenocarcinoma. We demonstrated previously that GAED is genetically characterized by frequent TP53 mutation. In this study, we aimed to further clarify the mechanism of inactivation of TP53 in GAED in the light of promoter methylation of TP53, and expression of methylation-associated proteins such as Ten-eleven translocation (TET) 1 and 5-hydroxymethylcytosine (5-hmc) in addition to ATM mutations. Read More

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December 2018

Effects of biochar and dicyandiamide combination on nitrous oxide emissions from Camellia oleifera field soil.

Environ Sci Pollut Res Int 2018 Dec 15. Epub 2018 Dec 15.

Ministry of Education and Jiangxi Key Laboratory of Crop Physiology, Ecology and Genetic Breeding, Jiangxi Agricultural University, Nanchang, 330045, China.

Greenhouse gas emissions from agricultural soils contribute substantially to global atmospheric composition. Nitrous oxide (NO) is one important greenhouse gas induces global warming. Nitrification inhibitors (NI) or biochar can be effective soil NO emission mitigation strategies for agricultural soils. Read More

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December 2018

Novel flourescent spiroborate esters: potential therapeutic agents in in vitro cancer models.

Mol Biol Rep 2018 Dec 15. Epub 2018 Dec 15.

Department of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala, India.

The current treatment system in cancer therapy, which includes chemotherapy/radiotherapy is expensive and often deleterious to surrounding healthy tissue. Presently, several medicinal plants and their constituents are in use to manage the development and progression of these diseases.They have been found effective, safe, and less expensive. Read More

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December 2018
2 Reads

Molecular Identification and Antifungal Susceptibility of Clinical Isolates of Sporothrix schenckii Complex in Medellin, Colombia.

Mycopathologia 2018 Dec 15. Epub 2018 Dec 15.

Grupo de Investigación Dermatológica, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia, Carrera 51D No. 62-29, Oficina 303, Edificio Manuel Uribe Angel, Medellín, Colombia.

Background: Sporotrichosis is a subcutaneous mycosis that affects humans and other animals. Infection prevails in tropical and subtropical countries. Until a few years ago, it was considered that two varieties of Sporothrix schenckii caused this mycosis, but by applying molecular taxonomic markers, it has been demonstrated that there are several cryptic species within S. Read More

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December 2018

The maternal reward system in postpartum depression.

Arch Womens Ment Health 2018 Dec 15. Epub 2018 Dec 15.

Department of Psychology, The Ohio State University, 1835 Neil Avenue, Columbus, OH, USA.

The experience of motherhood is most often emotionally positive and rewarding, but for many new mothers suffering from postpartum depression (PPD), this is not the case. Preclinical and clinical research has sought to uncover brain changes underlying PPD in order to gain a better understanding of how this disorder develops. This review focuses on the mesolimbic dopamine system, particularly the ventral tegmental area-nucleus accumbens pathway which has been implicated in the regulation of critical functions disrupted in PPD including mood, motivation, and mothering. Read More

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December 2018

Eating-related distress in advanced cancer patients with cachexia and family members: a survey in palliative and supportive care settings.

Support Care Cancer 2018 Dec 15. Epub 2018 Dec 15.

Department of Palliative Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima-ku, Osaka City, Osaka, 534-0021, Japan.

Purpose: Few studies have investigated nutrition impact symptoms and eating-related distress among advanced cancer patients and their families. This is a questionnaire survey to examine the severity of nutrition impact symptoms and the prevalence of eating-related distress among them in palliative and supportive care settings.

Methods: Questionnaires for patients and their families were preliminarily developed. Read More

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December 2018
1 Read

Official controls regarding artisanal ice cream shops: public health policies and consumer protection in the Italian and European legislative frameworks.

Ann Ig 2019 Jan-Feb;31(1):76-85

Department of Medical and Surgical Sciences and Translational Medicine, Sapienza University of Rome, Rome, Italy.

Ice cream is a widely enjoyed food that is especially popular during summer. To ensure it is safe and ready-to-eat for consumers, legislation imposes a series of obligations for food business operators, and for competent authorities that have to carry out official controls, including official sampling. This article reviews the general and specific requirements applicable to the premises where ice cream is produced, concerning aspects related to health notification obligations and to implementing and maintaining procedures based on the principles of the Hazard Analysis and Critical Control Point system. Read More

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December 2018

A Family with Autosomal Dominant Distal Renal Tubular Acidosis Presents with Atypical Phenotype Caused by a Missence Mutation (R388C) of the Human Kidney Anion Exchanger.

Nephron 2018 Dec 14:1-6. Epub 2018 Dec 14.

Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang,

Hereditary forms of distal renal tubular acidosis (dRTA) are rare and mainly caused by mutations in ATP6V1B1, ATP6V0A4 and SLC4A1. About 20 mutations in SLC4A1 gene have been found that are related to either autosomal dominant (AD) or autosomal recessive dRTA. AD dRTA often manifest as constitutional and can easily be delayed in diagnosis and treatment. Read More

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December 2018

Better Being Single? Omics Improves Kidney Organoids.

Nephron 2018 Dec 14;141(2):1-5. Epub 2018 Dec 14.

Context: Human kidney organoids are complex structures resembling nephron arrays, which can be derived in a variety of ways. Whether all of these differentiation protocols produce qualitatively similar organoid cell types is not yet clear. Subject of Review: A comparative analysis of 2 organoid differentiation protocols is recently reported in Cell Stem Cell [Wu et al. Read More

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December 2018

Clinically applicable delineation of the pallidal sensorimotor region in patients with advanced Parkinson's disease: study of probabilistic and deterministic tractography.

Authors:

J Neurosurg 2018 Dec 14:1-12. Epub 2018 Dec 14.

OBJECTIVEDeep brain stimulation (DBS) is an effective procedure in improving motor symptoms for patients with advanced Parkinson's disease (PD) through the use of high-frequency stimulation. Although one of the most commonly used target sites for DBS, sensorimotor regions of the globus pallidus interna (GPi) have yet to be thoroughly described with advanced neuroimaging analysis in vivo for human subjects. Furthermore, many imaging studies to date have been performed in a research setting and bring into question the feasibility of their applications in a clinical setting, such as for surgical planning. Read More

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December 2018

Evidence for Weak Selective Constraint on Human Gene Expression.

Genetics 2018 Dec 15. Epub 2018 Dec 15.

Stanford University

Gene expression variation is a major contributor to phenotypic variation in human complex traits. Selection on complex traits may therefore be reflected in constraint on gene expression. Here, we explore the effects of stabilizing selection on -regulatory genetic variation in humans. Read More

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December 2018

Work absence due to compensable RTCs in Victoria, Australia.

Inj Prev 2018 Dec 15. Epub 2018 Dec 15.

School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Introduction: RTC burden is commonly measured using fatality or hospitalisation statistics. However, non-fatal and less severe injuries contribute substantial economic and human costs, including work absence. In Victoria, Australia, two major compensation systems provide income support to employed people injured in RTCs; workers' compensation (if RTC occurred during work) and an RTC-specific compensation system. Read More

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December 2018

Role of TLR4 in the gut-brain axis in Parkinson's disease: a translational study from men to mice.

Gut 2018 Dec 15. Epub 2018 Dec 15.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

Objective: Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible role of the gut-brain axis in neurodegenerative diseases. Given the prominence of dysbiosis and colonic dysfunction in patients with Parkinson's disease (PD), we propose that toll-like receptor 4 (TLR4)-mediated intestinal dysfunction could contribute to intestinal and central inflammation in PD-related neurodegeneration.

Design: To test this hypothesis we performed studies in both human tissue and a murine model of PD. Read More

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December 2018

Metformin Affects Heme Function as a Possible Mechanism of Action.

G3 (Bethesda) 2018 Dec 15. Epub 2018 Dec 15.

Stanford University

Metformin elicits pleiotropic effects that are beneficial for treating diabetes, and as well as particular cancers and aging. In spite of its importance, a convincing and unifying mechanism to explain how metformin operates is lacking. Here we describe investigations into the mechanism of metformin action through heme and hemoprotein(s). Read More

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December 2018

Physical activity less than the recommended amount may prevent the onset of major biological risk factors for cardiovascular disease: a cohort study of 198 919 adults.

Br J Sports Med 2018 Dec 15. Epub 2018 Dec 15.

IMDEA Food Institute, CEI UAM+CSIC, Madrid, Spain.

Objectives: We examined the dose-response relationship between physical activity (PA) and incidence of cardiovascular disease (CVD) risk factors in adults in Taiwan.

Methods: This study included 1 98 919 participants, aged 18-97 years, free of CVD, cancer and diabetes at baseline (1997-2013), who were followed until 2016. At baseline, participants were classified into five PA levels: inactive' (0 metabolic equivalent of task (MET)-h/week), 'lower insufficiently active' (0. Read More

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December 2018

A serine in the first transmembrane domain of the human E3 ubiquitin ligase MARCH9 is critical for down-regulation of its protein substrates.

J Biol Chem 2018 Dec 15. Epub 2018 Dec 15.

Structural Biology, The Walter and Eliza Hall Institute of Medical Research, Australia.

The membrane-associated RING-CH (MARCH) family of membrane-bound E3 ubiquitin ligases regulates the levels of cell-surface membrane proteins, many of which are involved in immune responses. Although their role in ubiquitin-dependent endocytosis and degradation of cell-surface proteins is extensively documented, the features of MARCH proteins and their substrates that drive the molecular recognition events leading to ubiquitin transfer remain poorly defined. In this study, we sought to determine the features of human MARCH9 that are required for regulating the surface levels of its substrate proteins. Read More

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December 2018

Yield of peripheral sodium channels gene screening in pure small fibre neuropathy.

J Neurol Neurosurg Psychiatry 2018 Dec 15. Epub 2018 Dec 15.

Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands

Background: Neuropathic pain is common in peripheral neuropathy. Recent genetic studies have linked pathogenic voltage-gated sodium channel (VGSC) variants to human pain disorders. Our aims are to determine the frequency of , and variants in patients with pure small fibre neuropathy (SFN), analyse their clinical features and provide a rationale for genetic screening. Read More

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December 2018

In HPV-Positive HNSCC Cells, Functional Restoration of the p53/p21 Pathway by Proteasome Inhibitor Bortezomib Does Not Affect Radio- or Chemosensitivity.

Transl Oncol 2018 Dec 13;12(3):417-425. Epub 2018 Dec 13.

Department of Radiotherapy and Radiation Oncology, Philipps University of Marburg, University Hospital Gießen and Marburg, Baldingerstrasse, 35043 Marburg, Germany; Department of Radiotherapy and Radiation Oncology, University Hospital Jena, Bachstrasse 18, 07743 Jena, Germany. Electronic address:

Human papillomavirus (HPV) associated squamous cell carcinomas of the head and neck region (HPV+ HNSCCs) harbor diverging biological features as compared to classical noxa-induced (HPV-) HNSCC. One striking difference between subtypes is that the tumor suppressor gene TP53 is usually not mutated in HPV+ HNSCCs. However, p53 is inhibited by viral oncoprotein E6, leading to premature proteasomal degradation. Read More

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December 2018

FMRI correlates of olfactory processing in typically-developing school-aged children.

Psychiatry Res Neuroimaging 2018 Dec 2;283:67-76. Epub 2018 Dec 2.

Department of Radiology, University of Washington, Seattle, WA, United States; Center on Human Development and Disability, University of Washington, Seattle, WA, United States; Department of Biomedical Engineering, University of Washington, Seattle, WA, United States.

Human olfactory processing is understudied relative to other sensory modalities, despite its links to neurodevelopmental and neurodegenerative disorders. To address this limitation, we developed a fast, robust fMRI odor paradigm that is appropriate for all ages and levels of cognitive functioning. To test this approach, thirty-four typically developing children aged 7-12 underwent fMRI during brief, repeated exposure to phenylethyl alcohol, a flower-scented odor. Read More

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December 2018

Cabazitaxel and silibinin co-encapsulated cationic liposomes for CD44 targeted delivery: A new insight into nanomedicine based combinational chemotherapy for prostate cancer.

Biomed Pharmacother 2018 Dec 13;110:803-817. Epub 2018 Dec 13.

Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad 500037, India. Electronic address:

Cancer stem cells (CSCs) are the promising targets for cancer chemotherapy that cannot be eliminated by conventional chemotherapy. In this study cationic liposomes of cabazitaxel (CBX) and silibinin (SIL) were prepared with an aim to kill cancer cells and CSCs for prostate cancer. CBX act as cancer cell inhibitor and SIL as CSC inhibitor. Read More

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December 2018

Therapeutic targeting of angiogenesis molecular pathways in angiogenesis-dependent diseases.

Biomed Pharmacother 2018 Dec 13;110:775-785. Epub 2018 Dec 13.

Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Molecular Medicine Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Angiogenesis is a critical step in the progression of almost all human malignancies and some other life-threatening diseases. Anti-angiogenic therapy is a novel and effective approach for treatment of angiogenesis-dependent diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. In this article, we will review the main strategies developed for anti-angiogenic therapies beside their clinical applications, the major challenges, and the latest advances in the development of anti-angiogenesis-based targeted therapies. Read More

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December 2018
1 Read

Manilkara zapota (L.) P. Royen leaf water extract triggered apoptosis and activated caspase-dependent pathway in HT-29 human colorectal cancer cell line.

Biomed Pharmacother 2018 Dec 13;110:748-757. Epub 2018 Dec 13.

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia; Research Centre of Excellent, Nutrition and Non-Communicable Diseases (NNCD), Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia; Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia. Electronic address:

Manilkara zapota (L.) P. Royen (Family: Sapotaceae), commonly called as sapodilla, has been applied as traditional folk medicine for diarrhea and pulmonary infections. Read More

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December 2018

Simultaneous detection of ATP metabolites in human plasma and urine based on palladium nanoparticle and poly(bromocresol green) composite sensor.

Biosens Bioelectron 2018 Dec 8;126:758-766. Epub 2018 Dec 8.

Department of Chemistry and Institute of BioPhysio Sensor Technology (IBST), Pusan National University, Busan 46241, Republic of Korea. Electronic address:

A sensitive voltammetric sensor based on palladium nanoparticles (PdNPs) and poly-bromocresol green (pBG) composite layer immobilized on amide functionalized single-walled carbon nanotubes (AmSWCNTs) modified pyrolytic graphite (PdNPs:pBG/AmSWCNTs/PG) has been prepared for the simultaneous determination of adenosine triphosphate (ATP) catabolites, inosine (INO), hypoxanthine (HX), xanthine (XT), and uric acid (UA). The modified PdNPs:pBG/AmSWCNTs/PG was characterized by electrochemical experiments and surface analysis, which exhibited exceptional electrocatalytic effects towards the oxidation of INO, HX, XT, and UA with a significant enhanced peak current and well resolved peaks separation for all the analytes. The linear calibration curves were obtained in the concentration range of 0. Read More

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December 2018

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice.

Neurobiol Aging 2018 Nov 17;75:98-108. Epub 2018 Nov 17.

Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. Electronic address:

Type 2 diabetes mellitus (T2DM) increases the risk for Alzheimer's disease (AD). Human AD brains show reduced glucose metabolism as measured by [18F]fluoro-2-deoxy-2-D-glucose positron emission tomography (FDG-PET). Here, we used 14-month-old wild-type (WT) and APP/PS1 (APP/PS1) transgenic mice to investigate how a single dose of intranasal insulin modulates brain glucose metabolism using FDG-PET and affects spatial learning and memory. Read More

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November 2018

Chlamydia trachomatis ct143 stimulates secretion of proinflammatory cytokines via activating the p38/MAPK signal pathway in THP-1 cells.

Mol Immunol 2018 Dec 13;105:233-239. Epub 2018 Dec 13.

Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, 410078, China.

Chlamydia trachomatis (Ct) infections can cause bacterial sexually-transmitted and preventable blindness. The Ct infections induced excessive cytokines generation which attributed to pathologic changes in host cells. However, the precise mechanisms of Ct-induced cytokines production are still unclear. Read More

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December 2018

Regulation of TIM-3 expression in a human T cell line by tumor-conditioned media and cyclic AMP-dependent signaling.

Mol Immunol 2018 Dec 13;105:224-232. Epub 2018 Dec 13.

Department of Microbiology and Ajou University School of Medicine, Youngtongku Worldcupro 206, Suwon, 16499, Republic of Korea; Department of Biomedical Sciences (Graduate Program of Molecular Medicine), Ajou University Graduate School of Medicine, Suwon, 16499, Republic of Korea. Electronic address:

T cell immunoglobulin and mucin domain-3 (TIM-3) expression increases in exhausted T cells, which inhibits T cell function. TIM-3 expression is supposedly up-regulated in tumor-bearing individuals via chronic antigenic stimulation of T cells. Considering the immunosuppressive nature of the tumor microenvironment, we investigated whether tumor-secreted molecules might enhance TIM-3 expression in Jurkat T cells. Read More

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December 2018
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