5,071 results match your criteria Human Immunology [Journal]


MicroRNA layer of MHC in infectious diseases.

Hum Immunol 2019 Feb 12. Epub 2019 Feb 12.

Human and Medical Genetics Laboratory, Federal University of Pará, Brazil; Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Brazil.

The Major Histocompatibility Complex (MHC) harbors key genes of the immune response that are likely useful as biomarkers for infectious diseases. However, little is known about their microRNAs and what role they play in infections. The present study aimed to describe the miRNA genes in the MHC (MHC-miRNA), their variability and associations with infectious diseases. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.02.006DOI Listing
February 2019

IgMCD27 B cells possessed regulatory function and represented the main source of B cell-derived IL-10 in the synovial fluid of osteoarthritis patients.

Hum Immunol 2019 Feb 12. Epub 2019 Feb 12.

Department of Orthopedics, Shandong Qianfoshan Hospital, Shandong University, Jinan, Shandong, China. Electronic address:

Synovial inflammation is observed in patients with osteoathritis (OA) and likely contributed to its exacerbation. Regulatory B (Breg) cells are shown to suppress inflammation in various diseases, including rheumatoid arthritis (RA). To examine whether Breg cells also participated in OA, we examined the synovial fluid from OA patients, and compared with that in RA patients. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.02.007DOI Listing
February 2019

A Multiepitopic theoretical fusion construct based on in-silico epitope screening of known vaccine candidates for protection against wide range of enterobacterial pathogens.

Hum Immunol 2019 Feb 12. Epub 2019 Feb 12.

Department of Microbiology, Panjab University, Chandigarh, India. Electronic address:

Enterobacterial pathogens that have acquired antibiotic resistance genes are a leading cause of community and hospital acquired infections. In such a situation vaccination is considered as a better option to prevent such infections. In the current study reverse vaccinology approach has been used to select peptides from already known immunogenic proteins to design a chimeric construct. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.02.008DOI Listing
February 2019

High-resolution characterization of allelic and haplotypic HLA frequency distribution in a Spanish population using high-throughput next-generation sequencing.

Hum Immunol 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

Next-generation sequencing (NGS) at the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1 and -DRB3/4/5 loci was performed on 282 healthy unrelated individuals from different major regions of Spain. High-resolution HLA genotypes defined by full sequencing of class I loci and extended coverage of class II loci were obtained to determine allele frequencies and also to estimate extended haplotype frequencies. HLA alleles were typed at the highest resolution level (4-field level, 4FL); with exception of a minor deviation in HLA-DPA1, no statistically significant deviations from expected Hardy Weinberg Equilibrium (HWE) proportions were observed for all other HLA loci. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.02.005DOI Listing
February 2019

Genotyping of Italian patients with Behçet syndrome identified two novel ERAP1 polymorphisms using sequencing-based approach.

Hum Immunol 2019 Feb 8. Epub 2019 Feb 8.

Rheumatology Institute of Lucania (IReL) and Rheumatology Department of Lucania, San Carlo Hospital of Potenza, via Potito Petrone, Potenza, 85100, Italy; Basilicata Ricerca Biomedica (BRB) Foundation, Matera, 75100, Italy. Electronic address:

The endoplasmic reticulum aminopeptidase protein 1 gene (ERAP1) is related to several human diseases, including Behçet syndrome (BS), a multisystemic disorder with unknown etiology. ERAP1 is involved in immune response and its role can be influenced by gene single nucleotide variations (SNVs). We genotyped the ERAP1 whole structure in 50 consecutive BS patients and 50 ethnically-matched healthy controls using both bioinformatics and molecular methodologies. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.02.003DOI Listing
February 2019
1 Read

Quality control project of NGS HLA genotyping for the 17th International HLA and Immunogenetics Workshop.

Hum Immunol 2019 Feb 6. Epub 2019 Feb 6.

Histocompatibility, Immunogenetics, and Disease Profiling Laboratory, Stanford Blood Center, Palo Alto, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

The 17th International HLA and Immunogenetics Workshop (IHIW) organizers conducted a Pilot Study (PS) in which 13 laboratories (15 groups) participated to assess the performance of the various sequencing library preparation protocols, NGS platforms and software in use prior to the workshop. The organizers sent 50 cell lines to each of the 15 groups, scored the 15 independently generated sets of NGS HLA genotyping data, and generated "consensus" HLA genotypes for each of the 50 cell lines. Proficiency Testing (PT) was subsequently organized using four sets of 24 cell lines, selected from 48 of 50 PS cell lines, to validate the quality of NGS HLA typing data from the 34 participating IHIW laboratories. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.01.009DOI Listing
February 2019
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Towards the identification of the relative immunogenicity of individual HLA antibody epitopes.

Hum Immunol 2019 Feb 5. Epub 2019 Feb 5.

Leiden University Medical Center, Dept. Immunohaematology and Blood Transfusion, Albinusdreef 2, 2333 ZA Leiden, the Netherlands. Electronic address:

Recent data suggest that HLA epitope matching is more predictive for the formation of donor specific antibodies (DSA) after transplantation than classical HLA antigen matching. A proper definition of the epitopes and their immunogenicity is crucial for a broad clinical application of epitope matching in solid organ transplantation. For that purpose, a novel epitope component was started during the 17th International Histocompatibility and Immunogenetics Workshop. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.02.002DOI Listing
February 2019

Tools for Building, Analyzing and Evaluating HLA Haplotypes from Families.

Hum Immunol 2019 Feb 5. Epub 2019 Feb 5.

Histocompatibility, Immunogenetics & Disease Profiling Laboratory, Stanford Blood Center, Palo Alto, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

The highly polymorphic classical human leukocyte antigen (HLA) genes display strong linkage disequilibrium (LD) that results in conserved multi-locus haplotypes. For unrelated individuals in defined populations, HLA haplotype frequencies can be estimated using the expectation-maximization (EM) method. Haplotypes can also be constructed using HLA allele segregation from nuclear families. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.01.010DOI Listing
February 2019

Strategies for the measurements of expression levels and half-lives of HLA class I allotypes.

Hum Immunol 2019 Feb 5. Epub 2019 Feb 5.

Department of Laboratory Medicine and Pathology, Mayo Clinic, 5777 E. Mayo Blvd, Phoenix, AZ 85054, USA.

HLA class I molecules are highly polymorphic cell surface proteins that trigger immune responses by CD8 T cells and natural killer (NK) cells. Most humans express six different HLA class I proteins encoded by the HLA-A, HLA-B and HLA-C genes. HLA class I molecules bind to peptide antigens and present these antigens to T cell receptors (TCR) of CD8 T cells. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.02.001DOI Listing
February 2019

Immunotherapy in pediatric B-cell acute lymphoblastic leukemia.

Hum Immunol 2019 Feb 1. Epub 2019 Feb 1.

Division of Pediatric Hematology/Oncology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, United States; Department of Immunology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, United States. Electronic address:

Advances in multi-agent chemotherapy and supportive care have dramatically improved survival of children with B-cell acute lymphoblastic leukemia (B-ALL); however, patients with relapsed and refractory disease continue to represent a therapeutic challenge. Hematopoietic stem cell transplant was the first immunotherapeutic approach to be used in the treatment of patients with relapsed or refractory disease. However, novel therapies such as bispecific antibodies that engage T-cells and chimeric antigen receptor T-cells (CAR-T) therapy have emerged as novel FDA-approved options that have the potential to become the new standard of care for these difficult-to-treat leukemias. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01988859183118
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http://dx.doi.org/10.1016/j.humimm.2019.01.011DOI Listing
February 2019
1 Read
2.138 Impact Factor

Molecular events contributing to successful pediatric cardiac transplantation in HLA sensitized recipients.

Hum Immunol 2019 Jan 30. Epub 2019 Jan 30.

Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States. Electronic address:

Antibodies to HLA resulting in positive cytotoxicity crossmatch are generally considered a contraindication for cardiac transplantation. However, cardiac transplantations have been performed in children by reducing the Abs and modifying immunosuppression. To identify mechanisms leading to allograft acceptance in the presence of Abs to donor HLA, we analyzed priming events in endothelial cells (EC) by incubating with sera containing low levels of anti-HLA followed by saturating concentration of anti-HLA. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.01.008DOI Listing
January 2019

Exploring the ancestry and admixture of Mexican Oaxaca Mestizos from Southeast Mexico using next-generation sequencing of 11 HLA loci.

Hum Immunol 2019 Jan 29. Epub 2019 Jan 29.

Dept. of Immunology & Immunogenetics, InDRE, Secretary of Health, Mexico City, Mexico; Fundación Comparte Vida, A.C., Mexico City, Mexico. Electronic address:

The Mestizos of Oaxaca resulted from the admixture of Zapotecan Natives with Spaniards and Africans. We selected 112 donors from Oaxaca and applied next-generation sequencing to characterize exon and intron variants in complete or extended HLA genes. Some alleles found, are unique to Mexican Natives and most likely will be absent in most major ethnicities, namely: Caucasians, Africans or Asians. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.01.004DOI Listing
January 2019

Genetic diversity of HLA system in three populations from Zacatecas, Mexico: Zacatecas city, Fresnillo and rural Zacatecas.

Hum Immunol 2019 Jan 24. Epub 2019 Jan 24.

Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" (INCMNSZ), Mexico City, Mexico. Electronic address: http://www.innsz.mx.

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 453 Mexicans from the state of Zacatecas living in Zacatecas city (N = 84), Fresnillo (N = 103) and rural communities (N = 266) to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We find that the most frequent haplotypes for the state of Zacatecas include seven Native American most probable ancestry (A*02 ∼ B*39 ∼ DRB1*04 ∼ DQB1*03:02; A*02 ∼ B*35 ∼ DRB1*08 ∼ DQB1*04; A*24 ∼ B*39 ∼ DRB1*14 ∼ DQB1*03:01; A*02 ∼ B*35 ∼ DRB1*04 ∼ DQB1*03:02; A*24 ∼ B*35 ∼ DRB1*04 ∼ DQB1*03:02; A*68 ∼ B*35 ∼ DRB1*04 ∼ DQB1*03:02 and A*24 ∼ B*35 ∼ DRB1*08 ∼ DQB1*04) and two European MPA haplotypes (HLA ∼ A*01 ∼ B*08 ∼ DRB1*03:01 ∼ DQB1*02 and A*29 ∼ B*44 ∼ DRB1*07 ∼ DQB1*02). Admixture estimates revealed that the main genetic components in the state of Zacatecas are European (47. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.01.007DOI Listing
January 2019
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Distribution of HLA-DRB1, DPB1 and DQB1 alleles and haplotypes in Mongolian Minority in China.

Hum Immunol 2019 Jan 24. Epub 2019 Jan 24.

Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. Electronic address:

HLA-DRB1, -DQB1 and -DPB1 allele frequencies and estimated haplotype frequencies from 496 unrelated healthy Mongol subjects who living in Inner Mongolia Autonomous Region of China has been reported. HLA genes were genotyped using high-resolution sequence-based typing method. Chinese-Mongolian belongs to northern group of East Asians, but with its specific HLA-DRB1, DPB1 and DQB1 alleles and haplotypes characteristic. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.01.006DOI Listing
January 2019

T-cell receptor V and J usage paired with specific HLA alleles associates with distinct cervical cancer survival rates.

Hum Immunol 2019 Jan 23. Epub 2019 Jan 23.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, United States; Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States. Electronic address:

Cervical cancer is more strongly associated with a specific virus, Human Papilloma Virus (HPV), in otherwise healthy individuals, than is any other cancer. Thus, there is an expectation that an adaptive immune signature of cervical cancer would be highly apparent. Here we used a genomics approach to investigate the relationship between T-cell receptor (TCR) V and J usage and survival for patients diagnosed with cervical cancer, relying exclusively on tissue and blood exome files. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.01.005DOI Listing
January 2019
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Peptide trimming by endoplasmic reticulum aminopeptidases: Role of MHC class I binding and ERAP dimerization.

Hum Immunol 2019 Jan 22. Epub 2019 Jan 22.

Institut National de la Santé et de la Recherche Médicale, Unité 1151, 75015 Paris, France; Université Paris Descartes, Faculté de médecine, 75015 Paris, France; Centre National de la Recherche Scientifique, UMR8253, 75015 Paris, France. Electronic address:

Presentation of short peptides, produced through intracellular proteolysis, by MHC class I molecules (MHC-I) is the basis of adaptive immune surveillance and responses by cytolytic CD8 T lymphocytes. In the principal pathway of peptide processing for MHC-I that operates in all nucleated cells, MHC-I-binding peptides are produced through stepwise proteolysis starting with source protein degradation by cytosolic proteasome complexes. Among the fraction of proteasome products reaching the lumen of the endoplasmic reticulum, a significant proportion is thought to have a length exceeding that adapted to MHC class I binding and requires N-terminal trimming. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01988859193000
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http://dx.doi.org/10.1016/j.humimm.2019.01.003DOI Listing
January 2019
2 Reads

Point-counterpoint series: Confirmation of homozygous HLA alleles: Is it a necessity?

Authors:

Hum Immunol 2019 Jan 22. Epub 2019 Jan 22.

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http://dx.doi.org/10.1016/j.humimm.2019.01.002DOI Listing
January 2019
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CD3CD20 T cells and their roles in human diseases.

Hum Immunol 2019 Jan 11. Epub 2019 Jan 11.

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China. Electronic address:

CD3CD20 T cells are a population of CD3 T cells co-expressing CD20 that make up to ∼3-5% of the CD3 T-cell compartment in the peripheral blood of human beings. In healthy individuals, CD3CD20 T cells are heterogeneous for containing a lower proportion of CD4 cells, but produce higher levels of IL-17A and/or IFN-γ than those of CD3CD20 T cells. Recently, emerging studies have shown a pathogenic behavior of CD3CD20 T cells in autoimmune diseases and CD20 T-cell malignancies, and patients with the diseases may benefit from anti-CD20 immunotherapy to deplete these cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01988859183108
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http://dx.doi.org/10.1016/j.humimm.2019.01.001DOI Listing
January 2019
6 Reads

Donor derived HLA-G polymorphisms have a significant impact on acute rejection in kidney transplantation.

Hum Immunol 2019 Jan 2. Epub 2019 Jan 2.

University Medical Center Hamburg-Eppendorf, Department of Hepatobiliary and Transplant Surgery, Martinistraße 52, 20246 Hamburg, Germany.

Human leucocyte antigen G (HLA-G) is a non-classical HLA-class I antigen that exerts immunoregulatory functions. The polymorphisms 14-base pair (bp) insertion/deletion (ins/del) (rs1704) and +3142C > G (rs1063320) could modify the expression level of HLA-G. We genotyped 175 kidney recipients (41 with acute rejection and 134 without rejection) and additionally the corresponding donors for both polymorphisms in order to assess their impact on acute rejections one year after transplantation. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.12.011DOI Listing
January 2019

Sirolimus vs mycophenolate moftile in Tacrolimus based therapy following induction with Antithymocyte globulin promotes regulatory T cell expansion inhibits RORγt T-bet expression in kidney transplantation.

Hum Immunol 2018 Dec 28. Epub 2018 Dec 28.

Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Accumulating evidence suggests that regulatory T cells (Tregs) have a crucial role in immune tolerance and long-term graft survival. However, the influence of immunosuppressive drugs on the level of Tregs has not been fully understood. Therefore we prospectively compare the effect of two different calcineurin inhibitor (CNI)-based immunosuppression protocols on Tregs frequencies and expression of regulatory and effector T cell-related genes in renal transplant recipients. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.12.010DOI Listing
December 2018

Interleukin-6 promotor gene polymorphisms and susceptibility to chronic hepatitis B virus in Egyptians.

Hum Immunol 2018 Dec 27. Epub 2018 Dec 27.

Biochemistry Department, National Liver Institute (NLI), Menoufiya University, Shebeen El-Kom, Menoufiya, Egypt.

Aim: To investigate the association between IL-6 polymorphisms (-174G/C, -572G/C and -597G/A) and susceptibility to chronic hepatitis B virus (CHB) infection.

Method: Total 108 subjects with CHB infection and 102 healthy controls were enrolled in this study. IL-6 (-174G/C) was genotyped using Mutagenically separated Polymerase Chain Reaction (MS-PCR) while sequence specific primers-PCR (SSP-PCR) was used for studying -572G/C and -597G/A. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.12.009DOI Listing
December 2018

Ethnic differences in CD1E, but not CD1A, gene polymorphisms between Sub-Saharan Africans, West Asians and Europeans.

Hum Immunol 2018 Dec 18. Epub 2018 Dec 18.

Laboratoire d'Immunologie et d'Histocompatibilité AP-HP, IUH and INSERM U662, Paris, France.

The five closely linked CD1A-E genes encode the human CD1 family of proteins. Few studies of the allele frequencies of these genes in African populations have been published so far. This study aimed to genotype CD1A and CD1E variants and to compare their frequencies in Sub-Saharan Africans from Gabon and Ivory Coast, and Non-Africans from Syria and France. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.12.008DOI Listing
December 2018

The variations of TRBV genes usages in the peripheral blood of a healthy population are associated with their evolution and single nucleotide polymorphisms.

Hum Immunol 2018 Dec 18. Epub 2018 Dec 18.

Clinical Research Institute, Sun Yat-Sen University Foshan Hospital, Foshan, China. Electronic address:

T cell receptors (TCRs) are a class of T cell surface molecules that recognize the antigen-derived peptides presented by the major histocompatibility complex (MHC) and are able to trigger a series of immune responses. TCRs are important members of the adaptive immune system that arose in the jawed fish 500 million years ago. T cell receptor beta variable (TRBV) genes have been widely used to characterize TCR repertoires. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.12.007DOI Listing
December 2018
2.138 Impact Factor

Cytokine-targeted therapy for the management of solid organ transplant recipients.

Hum Immunol 2018 Dec 16. Epub 2018 Dec 16.

Florida Hospital Transplant Institute, AdventHealth Orlando, 601 East Rollins St, Orlando, FL 32707, United States.

Introduction: The number of solid organ transplants completed annually continues to trend upwards each year. Despite this, maintenance immunosuppression available on the market has remained relatively stagnant. Standard triple immunosuppression, composed typically of tacrolimus, mycophenolate, and steroids, lead to many side effects that limit the use of these medications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01988859183022
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http://dx.doi.org/10.1016/j.humimm.2018.12.006DOI Listing
December 2018
6 Reads

Lower incidence of de novo donor-specific antibodies against HLA-DR in ABO-incompatible renal transplantation.

Hum Immunol 2018 Dec 12. Epub 2018 Dec 12.

Department of Renal Transplant Surgery, Aichi Medical University, School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan. Electronic address:

Recently, in vitro experiments have demonstrated that anti-blood group A/B antibody binding to endothelial cells induce a protective effect against antibody-mediated injury. This study aimed to clarify the potential clinical benefit of ABO incompatibility in donor-specific HLA antibody (DSA)-induced chronic antibody-mediated rejection (ABMR). We enrolled 215 ABO-incompatible renal transplant (ABO-I) and 467 ABO-identical/compatible renal transplant recipients (ABO-Id/C). Read More

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http://dx.doi.org/10.1016/j.humimm.2018.12.004DOI Listing
December 2018
2 Reads

Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: The effect of NOD2/CARD15 mutations in a Tunisian population.

Hum Immunol 2018 Dec 12. Epub 2018 Dec 12.

Immunogenetic Applied to Cells Therapy Research Unit, Immuno-Haematology and HLA-Typing Department, National Blood Transfusion Centre of Tunis, Tunis, Tunisia.

Bronchiolitis obliterans (BO) is a serious lung complication that can develop after allogenic stem cell transplantation. It has been suggested that single nucleotide polymorphisms (SNPs) that affect the NOD2/CARD15 gene impair its function and result in an uncontrolled innate immune response in the recipient, thereby leading to BO. One hundred eighty-one donor-recipient pairs were analyzed for the association between NOD2 gene variants (SNP8 [Arg702Trp], SNP12 [Gly908Arg], and SNP13 [Leu1007fsinsC]) and the occurrence of BO. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.12.005DOI Listing
December 2018
3 Reads

HLA in Colombia Wayu from Guajira Peninsula Amerindians: Pacific Ocean relationships.

Hum Immunol 2019 Feb 8;80(2):93-94. Epub 2018 Dec 8.

Departmentof Medicina, Ciencias de la Salud, Universidad del Norte, Barranquilla, Colombia.

Wayu Amerindians live around Guajira Peninsula shared by Colombia and Venezuela. Wayu from Colombia have been studied for their HLA profile and these data put in context with both genetic and cultural relatedness to Pacific Islanders. HLA-A*24 and HLA-B*35 (most likely HLA-A*24:02 and HLA-B*35:05) and HLA-DRB1*04:03 and HLA-DQB1*03:02 are shared both by Wayu and other Amerindians and Pacific Islanders in specific high frequency. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01988859183101
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http://dx.doi.org/10.1016/j.humimm.2018.12.003DOI Listing
February 2019
9 Reads

Functional variants of TNFAIP3 are associated with systemic lupus erythematosus in a cohort of Chinese Han population.

Hum Immunol 2019 Feb 5;80(2):140-145. Epub 2018 Dec 5.

The Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University, Changchun, China. Electronic address:

Tumor necrosis factor-alpha-induced protein 3 (TNFAIP3) is a negative regulator of NF-κB activity. We previously reported that the paired tandem polymorphic dinucleotides TT > A (rs148314165, rs200820567 of TNFAIP3) conferred the risk for systemic lupus erythematosus (SLE) in European and Korean populations. We investigated the genetic association of the TT > A variants, as well as the functional coding variant rs2230926 in exon 3 of TNFAIP3 in 1229 Chinese Han SLE patients and 1608 matched population controls. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.11.008DOI Listing
February 2019
1 Read

Suitability of dried DNA for long-range PCR amplification and HLA typing by next-generation sequencing.

Hum Immunol 2019 Feb 4;80(2):135-139. Epub 2018 Dec 4.

UNC Hospitals, Molecular Immunology Laboratory, Chapel Hill, NC 27514, United States; UNC-Chapel Hill School of Medicine, Department of Pathology & Laboratory Medicine, Chapel Hill, NC 27514, United States. Electronic address:

Storage and stable shipment of genomic DNA are of great concern to laboratories that may need to perform testing off archived samples. There are some dry-state storage methods that are available that have the potential to provide a way to store samples at room temperature for long periods of time as well as offer a means to ship DNA to other facilities without the same safety concerns that come with shipping liquid samples. The recovered DNA should be of sufficient integrity such that downstream applications can be performed without concern of the sample quality. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.12.002DOI Listing
February 2019
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Genetic polymorphisms of G protein-coupled receptor 65 gene are associated with ankylosing spondylitis in a Chinese Han population: A case-control study.

Hum Immunol 2019 Feb 4;80(2):146-150. Epub 2018 Dec 4.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China. Electronic address:

Objective: This study aimed to assess the association between two tag single nucleotide polymorphisms (SNPs) (rs68177277 and rs11624293) of G protein-coupled receptor 65 (GPR65) gene and ankylosing spondylitis (AS) susceptibility in a Chinese Han population.

Methods: 673 patients with AS diagnosed according to the modified New York criteria and 679 age- and gender-matched healthy controls were recruited. SNP genotyping for rs68177277 and rs11624293 polymorphisms were performed using the SNPscan technique. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.12.001DOI Listing
February 2019
3 Reads

Influence of the TNFSF4 rs1234315 polymorphism in the susceptibility to systemic lupus erythematosus and rheumatoid arthritis.

Hum Immunol 2018 Nov 20. Epub 2018 Nov 20.

Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. Electronic address:

Objectives: The tumour necrosis factor superfamily 4 (TNFSF4) is a candidate gene for autoimmune diseases. We investigated the relationship of this gene with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Chinese Guangxi population.

Methods: A total of 294 patients with SLE, 210 with RA, and 282 healthy controls were genotyped for single nucleotide polymorphism (SNP) rs1234315 using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Read More

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http://dx.doi.org/10.1016/j.humimm.2018.11.006DOI Listing
November 2018
4 Reads

Second update of the International Registry of HLA Epitopes. I. The HLA-ABC Epitope Database.

Hum Immunol 2019 Feb 17;80(2):103-106. Epub 2018 Nov 17.

Immunogenetics and Molecular Biology Laboratory, Federal University of Piauı, Teresina, Brazil.

The International Registry of HLA Epitopes (http://www.epregistry.com. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01988859183066
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http://dx.doi.org/10.1016/j.humimm.2018.11.007DOI Listing
February 2019
19 Reads

Perspective: HLA functional elements outside the antigen recognition domains.

Hum Immunol 2019 Jan 14;80(1):1-4. Epub 2018 Nov 14.

Department of Immunology and Microbial Diseases, Albany Medical College, Albany, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.humimm.2018.11.005DOI Listing
January 2019

Association of pro-inflammatory cytokines and monocyte subtypes in older and younger patients on clinical outcomes after mechanical circulatory support device implantation.

Hum Immunol 2019 Feb 14;80(2):126-134. Epub 2018 Nov 14.

Division of Cardiology, Department of Medicine, David Geffen School of Medicine, Los Angeles, CA 90095, United States.

Noninvasive immunologic analysis of peripheral blood holds promise for explaining the mechanism of development of adverse clinical outcomes, and may also become a method for patient risk stratification before or after mechanical circulatory support device (MCSD) implantation. Dysregulation of the innate immune system is associated with increased patient age but has yet to be evaluated in the older patient with advanced heart failure undergoing MCSD surgery. Patients pre- and post-MCSD implantation had peripheral blood mononuclear cells (PBMC) and serum isolated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01988859183102
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http://dx.doi.org/10.1016/j.humimm.2018.11.004DOI Listing
February 2019
8 Reads

HLA in Uros from Peru Titikaka Lake: Tiwanaku, Easter and Pacific Islanders.

Hum Immunol 2019 Feb 13;80(2):91-92. Epub 2018 Nov 13.

Department of Immunology, University Complutense, School of Medicine, Madrid Regional Blood Center, Madrid, Spain.

Uros people live in floating reed islands in Titikaka Lake in front of Puno town (Peru). They could have started Tiwanaku culture and shared genes and culture with Pacific Islanders; it is particularly relevant the giant hat covered men statues found in both Tiwanaku at Titikaka Lake shore and Easter Island (3700 km far from Chile in Pacific Ocean). These giants monoliths are very similar one another and unique in America and Pacific Islands. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.10.012DOI Listing
February 2019

The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease.

Hum Immunol 2018 Nov 9. Epub 2018 Nov 9.

Translational Research Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia; Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.

The oxytocinase subfamily of M1 aminopeptidases plays an important role in processing and trimming of peptides for presentation on major histocompatibility (MHC) Class I molecules. Several large-scale genomic studies have identified association of members of this family of enzymes, most notably ERAP1 and ERAP2, with immune-mediated diseases including ankylosing spondylitis, psoriasis and birdshot chorioretinopathy. Much is now known about the genetics of these enzymes and how genetic variants alter their function, but how these variants contribute to disease remains largely unresolved. Read More

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https://www.sciencedirect.com/journal/human-immunology/artic
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https://linkinghub.elsevier.com/retrieve/pii/S01988859183057
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http://dx.doi.org/10.1016/j.humimm.2018.11.002DOI Listing
November 2018
9 Reads

Maternal HLA-G*01:01:01:04 protects from anti-HLA-class II immunization in pregnant women.

Hum Immunol 2019 Feb 7;80(2):120-125. Epub 2018 Nov 7.

Aix Marseille Univ, CNRS, EFS, ADES, "Biologie des Groupes Sanguins", Marseille, France; Etablissement Français du Sang PACA Corse, Marseille, France. Electronic address:

Factors determining anti-HLA immunization are poorly understood, although anti-HLA immunization following pregnancy is well described. The HLA-G molecule has been extensively described for its implication in immunological tolerance, especially during pregnancy. Transplant studies show an association between HLA-G haplotypes and alloimmunization. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.11.003DOI Listing
February 2019
10 Reads

Intracellular antigen processing by ERAP2: Molecular mechanism and roles in health and disease.

Hum Immunol 2018 Nov 7. Epub 2018 Nov 7.

National Centre for Scientific Research Demokritos, Agia Paraskevi, Athens, Greece. Electronic address:

Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) is an intracellular enzyme localized in the ER that has been shown to play roles in the generation of peptides that serve as ligands for MHC class I (MHC-1) molecules. Although ERAP2 has been primarily described as an accessory and complementary enzyme to the homologous ERAP1, several lines of evidence during the last few years suggest that it can play distinct and important roles in processing antigenic peptides and influencing cellular cytotoxic immune responses. Such emerging evidence has been shaping ERAP2 as a potentially tractable target for regulating select autoimmune and anti-cancer responses for therapeutic purposes. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.11.001DOI Listing
November 2018
18 Reads

Does NGS typing highlight our understanding of HLA population diversity?: Some good reasons to say yes and a few to say be careful.

Hum Immunol 2019 Jan 2;80(1):62-66. Epub 2018 Nov 2.

Department of Genetics and Evolution - Anthropology Unit, University of Geneva and Institute of Genetics and Genomics in Geneva (IGE3), Switzerland. Electronic address:

This paper discusses the advantages provided by next generation sequencing (NGS) compared to traditional typings or limited sequencing strategies for the characterization of HLA population diversity based on four documented examples. We also comment the limitations of this approach by highlighting pitfalls in interpreting NGS data. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.10.004DOI Listing
January 2019

6-Locus HLA allele and haplotype frequencies in a population of 1075 Russians from Karelia.

Hum Immunol 2019 Feb 2;80(2):95-96. Epub 2018 Nov 2.

DKMS German Bone Marrow Donor Center, Tübingen, Germany. Electronic address:

A total of 1075 Russians from the Russian part of Karelia were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 using next generation sequencing methods. The haplotypic and allelic profiles as well as Hardy-Weinberg proportions of this population sample were evaluated. As the most frequent 6-locus haplotype, A*03:01 g ∼ B*07:02 g ∼ C*07:02 g ∼ DRB1*15:01 g ∼ DQB1*06:02 g ∼ DPB1*04:01 g was identified with an estimated frequency of 3. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.10.017DOI Listing
February 2019

Allele diversity of the killer cell immunoglobulin-like receptors KIR3DL1/S1 and the combination with their HLA ligands in Mexican Mestizos from Mexico City.

Hum Immunol 2018 Dec 23;79(12):834-838. Epub 2018 Oct 23.

Department of Immunology and Immunogenetics, InDRE, Secretary of Health, Mexico City, Mexico; Fundación Comparte Vida, A.C., Mexico City, Mexico. Electronic address:

Killer cell immunoglobulin-like receptors (KIRs), expressed on Natural Killer (NK) cells, activate/inhibit NK cell function through interactions with their HLA-A, B and C ligands. KIR3DL1 is one of the most polymorphic genes and its effect varies depending on the interaction of the specific allotype with its Bw4 ligand. We investigated the allelic diversity of KIR3DL1/S1 using sequence based typing and we typed as well, their Bw4 ligands in Mexican Mestizos of Mexico City. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.10.011DOI Listing
December 2018
7 Reads

Primary B-cell immunodeficiencies.

Hum Immunol 2018 Oct 22. Epub 2018 Oct 22.

Division of Allergy and Clinical Immunology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029-6574, United States. Electronic address:

Primary B-cell immunodeficiencies refer to diseases resulting from impaired antibody production due to either molecular defects intrinsic to B-cells or a failure of interaction between B-cells and T-cells. Patients typically have recurrent infections and can vary with presentation and complications depending upon where the defect has occurred in B-cell development or the degree of functional impairment. In this review, we describe B-cell specific immune defects categorized by presence or absence of peripheral B-cells, immunoglobulins isotypes and evidence of antibody impairment. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.10.015DOI Listing
October 2018
10 Reads

Protective association of HLA-DRB1*13:02, HLA-DRB1*04:06, and HLA-DQB1*06:04 alleles with cervical cancer in a Korean population.

Hum Immunol 2019 Feb 21;80(2):107-111. Epub 2018 Oct 21.

Particle Therapy Research Branch, National Cancer Center, Goyang, Republic of Korea. Electronic address:

Human leukocyte antigen (HLA) class II alleles have been previously associated with cervical cancer. However, these associations vary widely across racial and ethnic groups. Therefore, we evaluated the effect of HLA class II alleles on cervical cancer in a Korean population. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.10.013DOI Listing
February 2019
8 Reads

Genetic association between CD86 polymorphisms and the risk of sepsis in a Chinese Han population.

Hum Immunol 2018 Nov 6;79(11):817-820. Epub 2018 Jul 6.

Department of Surgery, Linyi People's Hospital, Linyi City, Shandong Province 276000, China. Electronic address:

Background: Sepsis is a clinical syndrome that is frequently observed after injury or infection, representing a leading cause of mortality worldwide. CD86 (B7-2) is a co-stimulatory molecule on antigen-presenting cells, and plays critical roles in immune responses.

Methods: A total of 135 sepsis patients and 151 healthy controls were recruited in the current case-control study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01988859183024
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http://dx.doi.org/10.1016/j.humimm.2018.07.002DOI Listing
November 2018
8 Reads

WITHDRAWN: Association of polymorphisms in CTLA4 and interleukin genes with Hashimoto's thyroiditis among Han Chinese: A case-control study.

Hum Immunol 2018 Oct 13. Epub 2018 Oct 13.

Department of Assistant Reproductive, Jinggangshan University Affiliated Hospital, Ji'an, Jiangxi 343000, China. Electronic address:

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http://dx.doi.org/10.1016/j.humimm.2018.10.010DOI Listing
October 2018

The MHC in the era of next-generation sequencing: Implications for bridging structure with function.

Hum Immunol 2019 Jan 12;80(1):67-78. Epub 2018 Oct 12.

Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Microbiome and Genetics Core, Building 37, Room 4140B, Bethesda, MD 20852, United States. Electronic address:

The MHC continues to have the most disease-associations compared to other regions of the human genome, even in the genome-wide association study (GWAS) and single nucleotide polymorphism (SNP) era. Analysis of non-coding variation and their impact on the level of expression of HLA allotypes has shed new light on the potential mechanisms underlying HLA disease associations and alloreactivity in transplantation. Next-generation sequencing (NGS) technology has the capability of delineating the phase of variants in the HLA antigen-recognition site (ARS) with non-coding regulatory polymorphisms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01988859183091
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http://dx.doi.org/10.1016/j.humimm.2018.10.002DOI Listing
January 2019
1 Read

On the structure-function of MHC class II molecules and how single amino acid polymorphisms could alter intracellular trafficking.

Hum Immunol 2019 Jan 12;80(1):15-31. Epub 2018 Oct 12.

Laboratoire d'Immunologie Moléculaire, Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université de Montréal, Canada.

Classical HLA class II molecules are highly polymorphic heterodimeric transmembrane proteins encoded by a polygenic cluster on chromosome 6. Polymorphic residues in the membrane-distal domains ensure that a large collection of microbial peptides can be bound in the human population. Still, the HLA-DR, -DP and -DQ isotypes show a high degree of conservation in their overall tertiary and quaternary structures, in line with their common function in T cell receptor activation. Read More

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http://dx.doi.org/10.1016/j.humimm.2018.10.001DOI Listing
January 2019

Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop.

Hum Immunol 2018 Dec 12;79(12):825-833. Epub 2018 Oct 12.

Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA. Electronic address:

The goals of the KIR component of the 17th International HLA and Immunogenetics Workshop (IHIW) were to encourage and educate researchers to begin analyzing KIR at allelic resolution, and to survey the nature and extent of KIR allelic diversity across human populations. To represent worldwide diversity, we analyzed 1269 individuals from ten populations, focusing on the most polymorphic KIR genes, which express receptors having three immunoglobulin (Ig)-like domains (KIR3DL1/S1, KIR3DL2 and KIR3DL3). We identified 13 novel alleles of KIR3DL1/S1, 13 of KIR3DL2 and 18 of KIR3DL3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01988859183092
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http://dx.doi.org/10.1016/j.humimm.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322681PMC
December 2018
18 Reads

Improved accuracy of clinical HLA genotyping by next-generation DNA sequencing affects unrelated donor search results for hematopoietic stem cell transplantation.

Hum Immunol 2018 Dec 11;79(12):848-854. Epub 2018 Oct 11.

Department of Pathology, University of California San Diego, La Jolla, CA, USA. Electronic address:

Matching of human leukocyte antigen (HLA) genes is critically important in hematopoietic stem cell transplantation (HSCT). HLA genes are highly polymorphic and HLA matching has historically been limited by technologies that are unable to unambiguously determine HLA genotypes. Next generation DNA sequencing (NGS) overcomes these limitations by enabling near full-gene sequences with phase determination for heterozygous alleles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01988859183093
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http://dx.doi.org/10.1016/j.humimm.2018.10.008DOI Listing
December 2018
4 Reads

IL-35 promoted STAT3 phosphorylation and IL-10 production in B cells, but its production was reduced in patients with coronary artery diseases.

Hum Immunol 2018 Dec 11;79(12):869-875. Epub 2018 Oct 11.

Faculty of Clinical Medicine, Dali University, Kunming, Yunnan, China.

Interleukin (IL)-35 is a heterodimeric cytokine composed of the IL-12A subunit and the Epstein-Barr virus induced gene 3 (EBI3) subunit. Binding of IL-35 with IL-12 receptor subunit beta 2 (IL-12RB2) and IL-6 signal transducer (IL-6ST) occupies the binding sites of IL-6, IL-12, and IL-27 and prevents their signal transduction. IL-35 is also shown to promote the development of regulatory T cells (Tregs) and regulatory B cells (Bregs). Read More

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http://dx.doi.org/10.1016/j.humimm.2018.10.009DOI Listing
December 2018
6 Reads