Search our Database of Scientific Publications and Authors

I’m looking for a

    3217 results match your criteria Human Herpesvirus Type 6

    1 OF 65

    Hyponatremia associated with human herpesvirus-6 (HHV-6) encephalitis after allogeneic hematopoietic stem cell transplantation: A presentation different from HHV-6 myelitis.
    Int J Hematol 2017 May 13. Epub 2017 May 13.
    Division of Hematology, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
    Human herpesvirus-6 (HHV-6) encephalitis and myelitis following allogeneic hematopoietic stem cell transplantation (HSCT) is frequently life-threatening. We retrospectively evaluated the clinical significance of hyponatremia in cases of HHV-6 encephalitis/myelitis. Using an institutional database and medical records, we identified and retrospectively analyzed 16 cases of HHV-6 encephalitis and/or myelitis after allogeneic HSCT. Read More

    The use of heparin in infertility and recurrent pregnancy loss: Are its antiviral properties at play?
    Med Hypotheses 2017 May 6;102:41-47. Epub 2017 Mar 6.
    Department of Medical Sciences, Microbiology, University of Ferrara, Italy.
    Recently, human herpesvirus 6 (HHV-6) has been implicated in cases of poor pregnancy outcomes. The ability of HHV-6 to disrupt endothelial cell functioning may inhibit the creation of an appropriate uterine environment for implantation and fetal development, resulting in infertility and pregnancy loss, among other complications. Heparin has been used to treat pregnant women who are predisposed to thrombosis, and it has also been used in some women with infertility or recurrent pregnancy loss without associated thrombotic events. Read More

    Human Herpesvirus 6 (HHV-6) necrotizing encephalitis, a rare condition in immunocompromised patients: The importance of brain biopsy associated with HHV-6 testing.
    J Neurol Sci 2017 Jun 6;377:112-115. Epub 2017 Apr 6.
    Neurological Intensive Care Unit, Neurology Department, Assistance Publique-Hôpitaux de Paris, Universitary Hospital La Pitié Salpêtrière-Charles Foix, and Sorbonne Universités, Pierre and Marie Curie University, Paris, France.

    Comparative evaluation of a laboratory developed real-time PCR assay and the RealStar(®) HHV-6 PCR Kit for quantitative detection of human herpesvirus 6.
    J Virol Methods 2017 May 2;246:112-116. Epub 2017 May 2.
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region; Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region; The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address:
    Background: HHV-6 reactivation in immunocompromised patients is common and may be associated with serious morbidity and mortality; therefore, early detection and initiation of therapy might be of benefit. Real-time PCR assays allow for early identification of HHV-6 reactivation to assist in providing a timely response. Thus, we compared the performance of an in-house developed HHV-6 quantitative PCR assay with a commercially available kit, the RealStar(®) HHV-6 PCR Kit. Read More

    Characterizing the cellular immune response to Parainfluenza virus 3.
    J Infect Dis 2017 May 2. Epub 2017 May 2.
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital, Houston, Texas, 77030, USA.
    Parainfluenza virus (PIV) 3 infections are a major cause of morbidity and mortality in immunocompromised individuals with no approved therapies. Our group has demonstrated the safety and efficacy of adoptively transferred virus-specific T cells for the prevention and treatment of a broad range of viral infections including BK virus, cytomegalovirus, adenovirus, human herpesvirus 6 and Epstein-Barr virus. However, this approach is restricted to well-characterized viruses with known immunogenic/protective T cell target antigens, precluding extension to PIV-3. Read More

    Molecular diagnosis of central nervous system opportunistic infections and mortality in HIV-infected adults in Central China.
    AIDS Res Ther 2017 2;14:24. Epub 2017 May 2.
    Basic Medical College of Wuhan University, Wuhan, China.
    Background: CSF PCR is the standard diagnostic technique used in resource-rich settings to detect pathogens of the CNS infection. However, it is not currently used for routine CSF testing in China. Knowledge of CNS opportunistic infections among people living with HIV in China is limited. Read More

    Herpesviruses hijack host exosomes for viral pathogenesis.
    Semin Cell Dev Biol 2017 Apr 26. Epub 2017 Apr 26.
    Infection and Immunity Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia. Electronic address:
    Herpesviruses are remarkable pathogens possessing elaborate mechanisms to seize various host cellular components for immune evasion, replication, and virion egress. As viruses are dependent upon their hosts, investigating this intricate interplay has revealed that the exosome pathway is utilised by alpha (Herpes Simplex Virus 1), beta (Human Cytomegalovirus, and Human Herpesvirus 6) and gamma (Epstein-Barr Virus, and Kaposi Sarcoma-associated Herpesvirus) herpesviruses. Virions and exosomes share similar properties and functions. Read More

    Kidney transplant after hematopoietic cell transplant in pediatrics: Infectious and immunosuppressive considerations.
    Pediatr Transplant 2017 Apr 27. Epub 2017 Apr 27.
    Department of Pediatrics, Division of Nephrology, University of Minnesota, Minneapolis, MN, USA.
    Pediatric patients requiring kidney transplant after hematopoietic cell transplant receive multiple courses of immunosuppression placing them at risk for infection. To elucidate potential risk factors for infection, we compared the immunosuppressive regimens and infectious complications of pediatric kidney transplant recipients at a single institution who had previously undergone hematopoietic cell transplant from different donors to similar patients reported in the literature. Among the initial four post-hematopoietic cell transplant kidney transplant patients reviewed, viremia episodes were universal, including BK virus, Epstein-Barr virus, and human herpesvirus-6, with one death from presumed BK virus encephalitis. Read More

    Variation within MBP gene predicts disease course in multiple sclerosis.
    Brain Behav 2017 Apr 9;7(4):e00670. Epub 2017 Mar 9.
    Menzies Institute for Medical ResearchUniversity of TasmaniaHobartTASAustralia.
    Objective: Prognosis following a first demyelinating event is difficult to predict, with no genetic markers of MS progression currently identified. Myelin basic protein (MBP) is a major component of the myelin sheath of CNS neurons and may play a central role in demyelinating diseases such as MS. However, genetic variation in MBP has not been implicated in MS onset risk in large genome-wide association studies. Read More

    A histological study of fulminant type 1 diabetes mellitus related to human cytomegalovirus reactivation.
    J Clin Endocrinol Metab 2017 Apr 10. Epub 2017 Apr 10.
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.
    Context: Fulminant type 1 diabetes mellitus (T1DM) is thought to be partly caused by virus infection.

    Objective: This study investigated the mechanism of β cell destruction in fulminant T1DM after drug-induced hypersensitivity syndrome (DIHS).

    Methods: We determined the localization of viruses of human cytomegalovirus (HCMV), human herpesvirus 6 (HHV-6) and Epstein-Barr virus (EBV), and the expression of interferon regulatory factor 3 (IRF3) and viral receptors of Z DNA binding protein 1 (ZBP1) and retinoic acid-inducible gene I (RIG-I), together with inflammatory cells by immunohistochemistry of pancreas from an autopsy fulminant T1DM patient with DIHS or seven subjects with normal glucose tolerance who underwent pancreatectomy. Read More

    Viral reactivations and associated outcomes in the context of immune reconstitution after pediatric hematopoietic cell transplantation.
    J Allergy Clin Immunol 2017 Apr 7. Epub 2017 Apr 7.
    Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands; Pediatric Blood and Marrow Transplantation Program, University Medical Centre Utrecht, Utrecht, The Netherlands. Electronic address:
    Background: Viral reactivations (VRs) after hematopoietic cell transplantation (HCT) contribute to significant morbidity and mortality. Timely immune reconstitution (IR) is suggested to prevent VR.

    Objectives: We studied the relation between IR (as a continuous predictor over time) and VR (as a time-varying predictor) and the relation between VR and other clinical outcomes. Read More

    Pericardial Effusion Following Hematopoietic Cell Transplantation in Children and Young Adults Is Associated with Increased Risk of Mortality.
    Biol Blood Marrow Transplant 2017 Apr 5. Epub 2017 Apr 5.
    Department of Pediatrics, Division of Stem Cell Transplant and Regenerative Medicine, Stanford University School of Medicine, Stanford, California. Electronic address:
    Hematopoietic cell transplantation (HCT) is curative for many pediatric malignant and nonmalignant disorders but is associated with significant morbidity and mortality, including the development of pericardial effusion (PEF). We report the results of a retrospective chart review performed to assess the incidence, risk factors, and prognostic significance of PEF in pediatric HCT recipient at Lucile Packard Children's Hospital of Stanford University. A total of 119 patients undergoing HCT between January 2010 and December 2013 were selected through the hospital's Pediatric Stem Cell Transplant Program database. Read More

    Human herpesvirus 6 encephalitis followed by acute disseminated encephalomyelitis in an immunocompetent adult.
    Rinsho Shinkeigaku 2017 Apr 30;57(4):174-179. Epub 2017 Mar 30.
    Department of Neurology, Dokkyo Medical University.
    A 26-year-old, otherwise healthy man presented with visual abnormality followed by loss of consciousness and convulsion. The patient then developed headache and fever 14 days later. Brain MRI showed hyperintensities in the left cingulate cortex. Read More

    Increased interleukin-1β and basic fibroblast growth factor levels in the cerebrospinal fluid during human herpesvirus-6B (HHV-6B) encephalitis.
    Biochem Biophys Res Commun 2017 May 22;486(3):706-711. Epub 2017 Mar 22.
    Department of Virology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.
    Human herpesvirus 6B (HHV-6B) causes exanthema subitum in infants and is known to be mildly pathogenic. However, HHV-6B infection can induce febrile seizures in a high percentage of patients, and in rare cases, result in encephalitis. We detected higher levels of interleukin (IL)-1β and basic fibroblast growth factor (bFGF) in the cerebrospinal fluid (CFS) of patients with HHV-6B encephalitis when compared to those in patients with non-HHV-6B-induced febrile seizures. Read More

    Myalgic encephalomyelitis/chronic fatigue syndrome and gulf war illness patients exhibit increased humoral responses to the herpesviruses-encoded dUTPase: Implications in disease pathophysiology.
    J Med Virol 2017 Mar 17. Epub 2017 Mar 17.
    Department of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio.
    Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI) are debilitating diseases with overlapping symptomology and there are currently no validated tests for definitive diagnosis of either syndrome. While there is evidence supporting the premise that some herpesviruses may act as possible triggers of ME/CFS, the involvement of herpesviruses in the pathophysiology of GWI has not been studied in spite of a higher prevalence of ME/CFS in these patients. We have previously demonstrated that the deoxyuridine triphosphate nucleotidohydrolases (dUTPase) encoded by Epstein-Barr virus (EBV), human herpesvirus-6 (HHV-6), and varicella-zoster virus (VZV) possess novel functions in innate and adaptive immunity. Read More

    Decreased HHV-6 IgG in Alzheimer's Disease.
    Front Neurol 2017 20;8:40. Epub 2017 Feb 20.
    Department of Medical Sciences, Uppsala University , Uppsala , Sweden.
    Human herpesviruses have previously been implicated in the pathogenesis of Alzheimer's disease (AD) but whether they are causal, facilitating, or confounding factors is yet to be established. A total of 50 AD subjects and 52 non-demented (ND) controls were analyzed in a multiplex assay for IgG reactivity toward herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), and human herpesvirus 6 (HHV-6). The HHV-6 IgG reactivity was significantly lower in AD subjects compared to ND controls, whereas there were no differences in HSV, VZV, or CMV antibody levels between the groups. Read More

    Detection of inherited chromosomally integrated HHV-6 (ciHHV-6) in a marker chromosome.
    Eur J Haematol 2017 Jun 31;98(6):635-637. Epub 2017 Mar 31.
    Section of Haematology, University of Ferrara, Ferrara, Italy.
    Objectives: Inherited chromosomally integrated human herpesvirus-6 (ciHHV-6) is characterised by the complete HHV-6 genome integration into the host germ line genome and is vertically transmitted with a Mendelian inheritance. By now, the only relationship between ciHHV-6 and diseases seems to be with angina pectoris.

    Methods: We report a case of an 82-year-old man diagnosed with diffuse large B-cell lymphoma (DLBCL) on October 2014. Read More

    Risk factors of human herpesvirus 6 encephalitis/myelitis after allogeneic hematopoietic stem cell transplantation.
    Transpl Infect Dis 2017 Feb 16. Epub 2017 Feb 16.
    Department of Hematology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
    Background: Human herpesvirus 6 (HHV-6) encephalitis/myelitis is now a well-known complication after allogeneic stem cell transplantation (allo-HSCT), particularly after cord blood transplantation (CBT). In this study, we evaluated the risk factors of HHV-6 encephalitis/myelitis.

    Methods: We evaluated 253 patients who received allo-HSCT from 2007 to 2015 at our institute. Read More

    Human Herpesvirus 6A Exhibits Restrictive Propagation with Limited Activation of the Protein Kinase R-eIF2α Stress Pathway.
    J Virol 2017 May 13;91(9). Epub 2017 Apr 13.
    Department of Cell Research and Immunology and S. Daniel Abraham Institute for Molecular Virology, Tel Aviv University, Tel Aviv, Israel
    The eIF2α protein plays a critical role in the regulation of translation. The production of double-stranded RNA (dsRNA) during viral replication can activate protein kinase R (PKR), which phosphorylates eIF2α, leading to inhibition of the initial step of translation. Many viruses have evolved gene products targeting the PKR-eIF2a pathway, indicating its importance in antiviral defense. Read More

    Investigations in GABAA receptor antibody-associated encephalitis.
    Neurology 2017 Mar 15;88(11):1012-1020. Epub 2017 Feb 15.
    From the Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) (M.S., M.P.-P., T.A., M.R.R., F.G., J.D.), University of Barcelona, Spain; University of Lausanne (UNIL) (M.S.), Switzerland; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (M.P.-P., T.A., M.R.R., J.D., F.G.), Madrid, Spain; Neurology Service (T.A., J.D.), Hospital Sant Joan de Déu, Barcelona, Spain; Neurology Division, Hospital das Clínicas (M.M.S.), São Paulo University, Brazil; Hospital de Base (F.J.C.), Brasília, Brazil; Service of Neurology (M.I.B.A.) and Service of Immunology (M.R.J.B.), University Hospital of Son Espases, Mallorca, Spain; Department of Neurology (L.B., M.G.), Children's Hospital, Boston, MA; Pediatric Neurology Section (A.F.), Vall d'Hebron University Hospital, Barcelona, Spain; Hospital Nacional Edgardo Rebagliati Martins (R.L.C.O.), Lima, Peru; Department of Neurology (M.R.R., J.D.), University of Pennsylvania, Philadelphia; Service of Neurology (F.G., J.D.), Hospital Clínic; and Catalan Institution for Research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.
    Objective: To report the clinical features, comorbidities, receptor subunit targets, and outcome in patients with anti-GABAA receptor (GABAAR) encephalitis.

    Methods: Clinical study of 26 patients, including 17 new (April 2013-January 2016) and 9 previously reported patients. Antibodies to α1, β3, and γ2 subunits of the GABAAR were determined using reported techniques. Read More

    A Murine Herpesvirus Closely Related to Ubiquitous Human Herpesviruses Causes T-Cell Depletion.
    J Virol 2017 May 13;91(9). Epub 2017 Apr 13.
    Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA
    The human roseoloviruses human herpesvirus 6A (HHV-6A), HHV-6B, and HHV-7 comprise the Roseolovirus genus of the human Betaherpesvirinae subfamily. Infections with these viruses have been implicated in many diseases; however, it has been challenging to establish infections with roseoloviruses as direct drivers of pathology, because they are nearly ubiquitous and display species-specific tropism. Furthermore, controlled study of infection has been hampered by the lack of experimental models, and until now, a mouse roseolovirus has not been identified. Read More

    [Myocarditis].
    Rev Med Interne 2017 Feb 1. Epub 2017 Feb 1.
    Service de réanimation médicale, groupe hospitalier Pitié-Salpétrière, 47-83, boulevard de l'Hôpital, 75013 Paris, France.
    Acute myocarditis must be considered in patients with recent onset of cardiac failure or arrhythmia. Fulminant myocarditis is a distinct entity characterized by sudden onset of severe congestive heart failure or cardiogenic shock, usually following a flu-like illness, parvovirus B19, human herpesvirus 6, coxsackie virus and adenovirus being the most frequently viruses responsible for the disease. In this setting, early recognition of patients rapidly progressing to refractory cardiac failure and their immediate transfer to a medical-surgical center experienced in mechanical circulatory support is warranted. Read More

    Epidemiology of Multiple Herpes Viremia in Previously Immunocompetent Patients With Septic Shock.
    Clin Infect Dis 2017 May;64(9):1204-1210
    Department of Intensive Care Medicine.
    Background.: Systemic reactivations of herpesviruses may occur in intensive care unit (ICU) patients, even in those without prior immune deficiency. However, the clinical relevance of these events is uncertain. Read More

    Molecular diagnostic of cytomegalovirus, Epstein Barr virus and Herpes virus 6 infections among blood donors by multiplex real-time PCR in Ouagadougou, Burkina Faso.
    Pan Afr Med J 2016 3;24:298. Epub 2016 Aug 3.
    Biomolecular Research Center Pietro Annigoni Labiogene, UFR / SVT, University of Ouagadougou BP 364 Ouagadougou, Burkina Faso.
    Introduction: In most developing countries, Cytomegalovirus (CMV), Epstein Barr virus (EBV) and Herpes virus 6 (HHV-6) are not diagnosed in blood donors. The aim of this study is to determine the prevalence of these viruses in blood donors from the city of Ouagadougou, Burkina Faso.

    Methods: The study included 198 blood donors of the Regional Blood Transfusion Centre of Ouagadougou. Read More

    Bizarre cell dysplasia of the cervix.
    J Obstet Gynaecol Res 2017 Feb;43(2):345-351
    Šikl's Department of Pathology, Medical Faculty Hospital, Charles University, Pilsen, Czech Republic.
    Aim: The aim of this study was the characterization of a new subtype of high-grade cervical squamous intraepithelial lesion (HSIL) with enlarged cells containing bizarre nuclei: so-called bizarre cell dysplasia (BCD).

    Methods: A total of 29 cervical cone biopsy samples of this type of dysplasia were studied. Multi-target polymerase chain reaction and in situ hybridization human papillomavirus (HPV) detection was performed in all cases. Read More

    Acute liver dysfunction not resulting from hepatitis virus in immunocompetent children.
    Pediatr Int 2017 Jan 30. Epub 2017 Jan 30.
    Department of Pediatric Hepatology and Gastroenterology, Eastern Yokohama Hospital, Kanagawa, Japan.
    Background: The aim of the present study was to clarify the roles of cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesvirus 6 (HHV-6) in immunocompetent children with acute liver dysfunction not resulting from hepatitis virus.

    Methods: Sixty-eight children (median age, 3 years) hospitalized as a result of acute liver dysfunction were enrolled in this study. Hepatitis A, B, and C were excluded. Read More

    Concurrent pityriasis rosea and Bell's palsy.
    BMJ Case Rep 2017 Jan 23;2017. Epub 2017 Jan 23.
    Department of Dermatology, Saint Louis University, Saint Louis, Missouri, USA.
    Pityriasis rosea is a dermatological disease with a well-documented clinical appearance, but less is known about causes and treatment. Bell's palsy is a neurological condition leading to acute idiopathic hemifacial paralysis. Recent studies indicate that human herpesvirus (HHV) 6-7 reactivation may be a contributing factor to both conditions. Read More

    Human herpesviruses-6 and -7 encephalitis in immunocompetent infants: are they really so uncommon?
    J Biol Regul Homeost Agents 2016 Oct-Dec;30(4):1131-1136
    Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi” University of Messina, Italy.
    Human herpesviruses-6 and -7 (HHV-6 and 7) are considered uncommon causes of central nervous system infection and may occasionally cause encephalitis in young infants, however, the clinical syndrome and incidence are not well defined. In immunosuppressed hosts, reactivation is associated with a worse outcome such as encephalitis, hepatitis, or graft rejection. In immunocompetent hosts, this persistent infection is generally of no consequence. Read More

    Structural and Ultrastructural Alterations in Human Olfactory Pathways and Possible Associations with Herpesvirus 6 Infection.
    PLoS One 2017 10;12(1):e0170071. Epub 2017 Jan 10.
    A. Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Riga, Latvia.
    Structural and ultrastructural alterations in human olfactory pathways and putative associations with human herpesvirus 6 (HHV-6) infection were studied. The olfactory bulb/tract samples from 20 subjects with an unspecified encephalopathy determined by pathomorphological examination of the brain autopsy, 17 healthy age-matched and 16 younger controls were used. HHV-6 DNA was detected in 60, 29, and 19% of cases in these groups, respectively. Read More

    Divergent tropism of HHV-6AGS and HHV-6BPL1 in T cells expressing different CD46 isoform patterns.
    Virology 2017 Feb 2;502:160-170. Epub 2017 Jan 2.
    Department of Biomedicine, Aarhus University, Bartholins Allé 6, DK-8000 Aarhus, Denmark. Electronic address:
    CD46 is a receptor for HHV-6A, but its role as a receptor for HHV-6B is controversial. The significance of CD46 isoforms for HHV-6A and HHV-6B tropism is unknown. HHV-6AGS was able to initiate transcription of the viral genes U7 and U23 in the CD46(+)CD134(-) T-cell lines Peer, Jurkat, Molt3, and SupT1, whereas HHV-6BPL1 was only able to do so in Molt3 and SupT1, which expressed a CD46 isoform pattern different from Peer and Jurkat. Read More

    Association between human herpesvirus & human endogenous retrovirus and MS onset & progression.
    J Neurol Sci 2017 Jan 24;372:239-249. Epub 2016 Nov 24.
    Menzies Institute for Medical Research, University of Tasmania, Australia. Electronic address:
    This review discusses the role of Epstein-Barr virus (EBV), human herpesvirus 6 (HHV6) and human endogenous retroviruses (HERVs) in the onset and progression of multiple sclerosis (MS). Although EBV has been established as one of the causal factors in MS onset, its role in MS progression is still uncertain. Moreover, interactions between EBV and other risk factor on MS development still need more investment. Read More

    Human herpesvirus 6 lymphadenitis in drug rash with eosinophilia and systemic symptoms syndrome: a lymphoma mimic.
    Histopathology 2017 Jun 10;70(7):1166-1170. Epub 2017 Mar 10.
    Departments of Pathology and Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
    Aims: Lymphadenopathy, haematological abnormalities and constitutional symptoms are among the non-specific manifestations seen in drug rash with eosinophilia and systemic symptoms (DRESS), an uncommon but potentially fatal cutaneous adverse drug reaction. The ubiquitous human herpesvirus 6 (HHV-6) plays a unique role in the pathogenesis of DRESS, with emerging data suggesting that reactivation occurs in most cases and contributes to the clinical manifestations, including lymphadenopathy. Further, in the appropriate clinical context, demonstration of HHV-6 reactivation may lend support to a diagnosis of DRESS. Read More

    Human Herpesvirus 6 Infection Presenting as an Acute Febrile Illness Associated with Thrombocytopenia and Leukopenia.
    Case Rep Pediatr 2016 17;2016:2483183. Epub 2016 Nov 17.
    Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, SI-1000 Ljubljana, Slovenia.
    We present an infant with acute fever, thrombocytopenia, and leukopenia, coming from an endemic region for tick-borne encephalitis, human granulocytic anaplasmosis, and hantavirus infection. The primary human herpesvirus 6 infection was diagnosed by seroconversion of specific IgM and IgG and by identification of viral DNA in the acute patient's serum. The patient did not show skin rash suggestive of exanthema subitum during the course of illness. Read More

    High Prevalence of Infectious Adeno-associated Virus (AAV) in Human Peripheral Blood Mononuclear Cells Indicative of T Lymphocytes as Sites of AAV Persistence.
    J Virol 2017 Feb 31;91(4). Epub 2017 Jan 31.
    Institute of Virology, Campus Benjamin Franklin, Charité Medical School, Berlin, Germany
    Seroepidemiology shows that infections with adeno-associated virus (AAV) are widespread, but diverse AAV serotypes isolated from humans or nonhuman primates have so far not been proven to be causes of human disease. In view of the increasing success of AAV-derived vectors in human gene therapy, definition of the in vivo sites of wild-type AAV persistence and the clinical consequences of its reactivation is becoming increasingly urgent. Here, we identify the presumed cell type for AAV persistence in the human host by highly sensitive AAV PCRs developed for the full spectrum of human AAV serotypes. Read More

    The plasma virome of febrile adult Kenyans shows frequent parvovirus B19 infections and a novel arbovirus (Kadipiro virus).
    J Gen Virol 2016 Dec 24;97(12):3359-3367. Epub 2016 Oct 24.
    8​Department of Laboratory Medicine, University of California at San Francisco, CA, USA 2​Blood Systems Research Institute, San Francisco, CA, USA.
    Viral nucleic acids present in the plasma of 498 Kenyan adults with unexplained fever were characterized by metagenomics analysis of 51 sample pools. The highest to lowest fraction of plasma pools was positive for parvovirus B19 (75 %), pegivirus C (GBV-C) (67 %), alpha anellovirus (59 %), gamma anellovirus (55 %), beta anellovirus (41 %), dengue virus genotype 2 (DENV-2) (16 %), human immunodeficiency virus type 1 (6 %), human herpesvirus 6 (6 %), HBV (4 %), rotavirus (4 %), hepatitis B virus (4 %), rhinovirus C (2 %), Merkel cell polyomavirus (MCPyV; 2 %) and Kadipiro virus (2 %). Ranking by overall percentage of viral reads yielded similar results. Read More

    Cytokine and cellular responses to human herpesvirus-6B in patients with B-acute lymphoblastic leukemia.
    Microbiol Immunol 2016 Nov;60(11):770-777
    Laboratory of Transmissible Diseases and Biological Active Substances, LR99ES27, Faculty of Pharmacy, University of Monastir, Street Avicenne 5000, Monastir, Tunisia.
    Primary infection with human herpesvirus-6 (HHV-6), is followed by its lifelong persistence in the host. Most T-cell responses to HHV-6 have been characterized using peripheral blood from healthy adults; however, the role of HHV-6 infection in immune modulation has not been elucidated for some diseases. Therefore, in this study the immune response to HHV-6 infection in patients with B-acute lymphoblastic leukemia (B-ALL) was analyzed. Read More

    Transmission of chromosomally integrated human herpesvirus 6 via cord blood transplantation.
    Transpl Infect Dis 2017 Feb 25;19(1). Epub 2016 Dec 25.
    Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
    Chromosomally integrated human herpesvirus 6 (ciHHV-6) can be transmitted via allogeneic hematopoietic cell transplantation. To date, only a few cases have been reported. Here, we report a case identified as transmission of ciHHV-6 via cord blood transplantation. Read More

    Progress in Quantitative Viral Load Testing: Variability and Impact of the WHO Quantitative International Standards.
    J Clin Microbiol 2017 Feb 16;55(2):423-430. Epub 2016 Nov 16.
    Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
    It has been hoped that the recent availability of WHO quantitative standards would improve interlaboratory agreement for viral load testing; however, insufficient data are available to evaluate whether this has been the case. Results from 554 laboratories participating in proficiency testing surveys for quantitative PCR assays of cytomegalovirus (CMV), Epstein-Barr virus (EBV), BK virus (BKV), adenovirus (ADV), and human herpesvirus 6 (HHV6) were evaluated to determine overall result variability and then were stratified by assay manufacturer. The impact of calibration to international units/ml (CMV and EBV) on variability was also determined. Read More

    [Molecular tests in diagnosis of Cytomegalovirus (CMV), human herpesvirus 6 (HHV-6) and Epstein-Barr virus (EBV) using real-time PCR in HIV positive and HIV-negative pregnant women in Ouagadougou, Burkina Faso].
    Pan Afr Med J 2016 12;24:223. Epub 2016 Jul 12.
    Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA), LABIOGENE UFR/SVT, Université de Ouagadougou BP 364 Ouagadougou, Burkina Faso.
    Introduction: Herpesvirus EBV, CMV and HHV-6 are viruses that evolve based on pandemic modeling and are responsible for congenital infections causing severe sequelae in infants. This study aims to determine the prevalence of CMV, EBV and HHV-6 among HIV (+) and HIV (-) pregnant women in Ouagadougou.

    Methods: In this study 200 blood plasma samples taken from pregnant women, of whom 100 with HIV(+) and 100 with HIV(-), were analyzed using multiplex real-time PCR which detected three infections (EBV, CMV and HHV-6). Read More

    HHV-6 and seizure: A systematic review and meta-analysis.
    J Med Virol 2017 Jan 9;89(1):161-169. Epub 2016 Aug 9.
    Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
    Human herpesvirus-6 (HHV-6) is a common infection in childhood. This systematic review aims to assess the relationship between HHV-6 infection and seizure disorders based on available literature. MEDLINE database was searched using a search strategy. Read More

    Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer.
    Cancer Epidemiol Biomarkers Prev 2017 Mar 24;26(3):425-427. Epub 2016 Oct 24.
    Division of Infectious Disease and Immunity, CHU de Québec Research Center and Department of Microbiology-Infectious Disease, Quebec, Canada.
    Background: Inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) is a condition observed in approximately 1% of the population. Whether such a genetic alteration predisposes to cancer development in currently unknown. Two studies were conducted to determine whether iciHHV-6 is associated with cancer development. Read More

    Human Herpesvirus 6 Infection Following Haploidentical Transplantation: Immune Recovery and Outcome.
    Biol Blood Marrow Transplant 2016 Dec 30;22(12):2250-2255. Epub 2016 Sep 30.
    Unit of Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy. Electronic address:
    Human herpesvirus 6 (HHV-6) is increasingly recognized as a potentially life-threatening pathogen in allogeneic hematopoietic stem cell transplantation (alloSCT). We retrospectively evaluated 54 adult patients who developed positivity to HHV-6 after alloSCT. The median time from alloSCT to HHV-6 reactivation was 34 days. Read More

    Herpes and Alzheimer's Disease: Subversion in the Central Nervous System and How It Might Be Halted.
    J Alzheimers Dis 2016 Oct;54(4):1273-1281
    The last 8 or so years have seen a large increase in the number of studies supporting the concept of a major role for herpes simplex virus type 1 (HSV1) in Alzheimer's disease (AD). The main advances have been made through studies in humans and in mice, investigating the likelihood of reactivation of the latent virus in brain. Others have aimed to explain the mechanisms in cells whereby the increase in amyloid-beta (Aβ) production on HSV1 infection of cells and mouse brains occurs, and the reason that infected cells make this increase. Read More

    CD4+ T Cells Coexpressing CD134 (OX40) Harbor Significantly Increased Levels of Human Herpesvirus 6B DNA Following Umbilical Cord Blood Transplantation.
    J Infect Dis 2016 Dec 4;214(12):1911-1915. Epub 2016 Oct 4.
    Division of Blood and Marrow Transplantation, Department of Pediatrics.
    Human herpesvirus 6B (HHV-6B) commonly reactivates after umbilical cord blood transplantation (UCBT) and is associated with delayed engraftment, fever, rash, and central nervous system dysfunction. Recently, CD134 (OX40) has been implicated as a potential viral entry receptor. We evaluated CD4(+)CD134(+)/(neg-lo) and CD8(+)CD134(+)/(neg-lo) cells at day 28 after UCBT in 20 subjects with previously documented HHV-6 reactivation and persistent viremia. Read More

    Distribution and effects of amino acid changes in drug-resistant α and β herpesviruses DNA polymerase.
    Nucleic Acids Res 2016 Nov 29;44(20):9530-9554. Epub 2016 Sep 29.
    Rega Institute for Medical Research, Department Microbiology and Immunology, KU Leuven, Minderbroedersstraat 10, 3000, Leuven, Belgium
    Emergence of drug-resistance to all FDA-approved antiherpesvirus agents is an increasing concern in immunocompromised patients. Herpesvirus DNA polymerase (DNApol) is currently the target of nucleos(t)ide analogue-based therapy. Mutations in DNApol that confer resistance arose in immunocompromised patients infected with herpes simplex virus 1 (HSV-1) and human cytomegalovirus (HCMV), and to lesser extent in herpes simplex virus 2 (HSV-2), varicella zoster virus (VZV) and human herpesvirus 6 (HHV-6). Read More

    Association of active human herpesvirus-6 (HHV-6) infection with autoimmune thyroid gland diseases.
    Clin Microbiol Infect 2017 Jan 30;23(1):50.e1-50.e5. Epub 2016 Sep 30.
    Riga Stradiņš University, A. Kirchenstein Institute of Microbiology and Virology, Latvia.
    Objectives: Viral infections frequently have been cited as important environmental factors implicated in the onset of autoimmune thyroiditis (AIT). The aim of this study was to determine the involvement of HHV-6 infection in the development of autoimmune thyroiditis.

    Methods: This study included 45 patients (42 female and 3 male; median age 47. Read More

    1 OF 65