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    3332 results match your criteria Human Herpesvirus Type 6

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    Human herpesvirus-6 pneumonitis in a patient with follicular lymphoma following immunochemotherapy with rituximab.
    Infect Drug Resist 2018 14;11:701-705. Epub 2018 May 14.
    Department of Medicine, Division of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Primary infection with human herpesvirus-6 (HHV-6) commonly occurs at an early age in children, most often at 3 years of age, and is associated with childhood diseases, such as exanthema subitum, hepatitis, febrile convulsions, or encephalitis. However, the virus occasionally reactivates from its latent state in immunosuppressed adults, especially post-transplant, resulting in serious disseminated, sometimes life-threatening end-organ complications. Herein, we report a case of a 68-year-old man with relapsed follicular lymphoma who developed HHV-6 pneumonitis. Read More

    High prevalence and correlates of human herpesvirus-6A in nevocytic nevus and seborrheic diseases: Implication from a pilot study of skin patient tissues in Shanghai.
    J Med Virol 2018 May 4. Epub 2018 May 4.
    MOE & MOH Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, P. R. China.
    Skin disorders vary greatly in symptoms and severity, and the causes of these disorders are largely unknown. Human herpesvirus (HHV) has been shown to cause many diseases. However, the prevalence and correlate of each HHV infection with different skin disorders remains obscure. Read More

    Acute encephalopathy with biphasic seizures and late reduced diffusion associated with sepsis.
    Pediatr Rep 2018 Mar 29;10(1):7424. Epub 2018 Mar 29.
    Division of Pediatrics, Uji-Tokushukai Medical Center, Uji, Kyoto, Japan.
    Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) develops in association with systemic as well as central nervous system (CNS) viral or bacterial infections. AESD is most often noted with influenza or human herpesvirus 6 infection in previously healthy infants. However, AESD has also been reported in an infant with developmental retardation and in a mentally and motor-disabled adolescent. Read More

    Using Droplet Digital PCR to Detect Coinfection of Human Herpesviruses 6A and 6B (HHV-6A and HHV-6B) in Clinical Samples.
    Methods Mol Biol 2018 ;1768:99-109
    Neuroimmunology Branch, Viral Immunology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA.
    Droplet digital™ polymerase chain reaction (ddPCR™) is a unique digital PCR technique that allows for absolute quantification of nucleic acid samples. This technique operates on the basis of amplification within water-oil emulsion droplets and can detect very small quantities of target molecules, yielding extremely precise data. Here, we describe in detail a ddPCR procedure for multiplexed detection of two clinically relevant herpesviruses, HHV-6A and HHV-6B. Read More

    Cross-sectional analysis of CD8 T cell immunity to human herpesvirus 6B.
    PLoS Pathog 2018 Apr 26;14(4):e1006991. Epub 2018 Apr 26.
    DZIF Research Group "Host Control of Viral Latency and Reactivation" (HOCOVLAR), Research Unit Gene Vectors, Helmholtz Zentrum München, Munich, Germany.
    Human herpesvirus 6 (HHV-6) is prevalent in healthy persons, causes disease in immunosuppressed carriers, and may be involved in autoimmune disease. Cytotoxic CD8 T cells are probably important for effective control of infection. However, the HHV-6-specific CD8 T cell repertoire is largely uncharacterized. Read More

    Human Herpesvirus-6B Reactivation Is a Risk Factor for Grades II to IV Acute Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.
    Biol Blood Marrow Transplant 2018 Apr 21. Epub 2018 Apr 21.
    Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, Washington; Department of Pediatrics, University of Washington, Seattle, Washington. Electronic address:
    Graft-versus-host disease (GVHD) is an important cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Many studies have suggested that human herpesvirus-6B (HHV-6B) plays a role in acute GVHD (aGVHD) after HCT. Our objective was to systematically summarize and analyze evidence regarding HHV-6B reactivation and development of aGVHD. Read More

    Distinctive Infectious Complications in Patients with Central Nervous System Lymphoma Undergoing Thiotepa, Busulfan, and Cyclophosphamide-Conditioned Autologous Stem Cell Transplantation.
    Biol Blood Marrow Transplant 2018 Apr 18. Epub 2018 Apr 18.
    Adult Bone Marrow Transplant (BMT) Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Medicine, Weill Cornell Medical College, New York, New York.
    We investigated the incidence of viral, fungal, bacterial, and parasitic infections observed in 57 patients with central nervous system lymphoma after thiotepa, busulfan, and cyclophosphamide-conditioned autologous stem cell transplantation (TBC-ASCT) and 79 patients with systemic non-Hodgkin lymphoma after traditional carmustine, etoposide, cytarabine, and melphalan-conditioned ASCT (BEAM-ASCT). Twenty of 57 (35%) TBC-ASCT patients had detectable viremia with human herpesvirus 6, cytomegalovirus, adenovirus, or BK virus, versus 9 of 79 (11%) BEAM-ASCT patients. Nine TBC-ASCT patients had clinically relevant viral infections (4 human herpesvirus 6, 2 cytomegalovirus, 1 adenovirus, 2 BK virus), versus 0 in the BEAM-ASCT group. Read More

    Clinical Significance of Human Herpesvirus 6 Positivity on the FilmArray Meningitis/Encephalitis Multiplex PCR Panel.
    Clin Infect Dis 2018 Apr 9. Epub 2018 Apr 9.
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
    A review of 15 patients who tested positive for HHV-6 on the FilmArray Meningitis/Encephalitis (M/E) panel revealed that the majority were unlikely to have HHV-6 encephalitis. Interpreting HHV-6 positive results on the M/E panel requires careful clinical judgment, as this finding may be clinically insignificant for many patients. Read More

    [Human herpesvirus-6 pneumonitis following autologous peripheral blood stem cell transplantation].
    Rinsho Ketsueki 2018 ;59(3):300-304
    Department of Hematology, Tokyo Medical University.
    A-46-year-old man was diagnosed with peripheral T cell lymphoma, not otherwise specified. He achieved a complete remission after pirarubicin, cyclophosphamide, vincristine, and prednisolone (THP-COP) therapy and successful autologous peripheral blood stem-cell transplantation (AutoSCT). However, 6 months post AutoSCT, he complained of fever. Read More

    Serologic markers of viral infection and risk of non-Hodgkin lymphoma: A pooled study of three prospective cohorts in China and Singapore.
    Int J Cancer 2018 Mar 25. Epub 2018 Mar 25.
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Rockville, MD.
    Incidence rates of non-Hodgkin lymphoma (NHL) and distributions of certain viruses differ between East Asian and Western populations. There are limited data on associations between serologic markers of multiple viral infections in pre-diagnostic blood and NHL risk in East Asians. We conducted a nested case-control study of 214 NHL cases and 214 matched controls from three population-based prospective cohorts in Shanghai and Singapore. Read More

    Prevalence of salivary human herpesviruses in pediatric multiple sclerosis cases and controls.
    Mult Scler 2018 Mar 1:1352458518765654. Epub 2018 Mar 1.
    National Institutes of Health, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
    Background: Multiple sclerosis (MS) is a multifactorial disease of unknown origin. The current paradigm is that disease develops in genetically susceptible individuals, influenced by environmental factors. Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6) have particularly strong associations with the disease. Read More

    [Encephalopathy due to human herpesvirus 6 infection as exanthema subitum complication].
    Arch Argent Pediatr 2018 Apr;116(2):e312-e314
    Unidad de Infectología Pediátrica, Hospital Materno-Infantil Miguel Servet, Zaragoza. España.
    The main clinical manifestation of human herpesvirus 6 is exanthema subitum (also known as roseola infantum) and febrile syndrome. Central nervous system manifestations are not unusual in herpesvirus 6 infection, and even though the pathophysiology is not clear, they need to be early diagnosed and treated in order to avoid potentially serious damage. We present the case of an immunocompetent 2-year-old girl with encephalitis as a complication of herpesvirus 6 infection. Read More

    Contributions of neurotropic human herpesviruses herpes simplex virus 1 and human herpesvirus 6 to neurodegenerative disease pathology.
    Neural Regen Res 2018 Feb;13(2):211-221
    Department of Neuroscience, University of Rochester; Department of Biomedical Genetics, University of Rochester, Rochester, NY, USA.
    Human herpesviruses (HVs) have developed ingenious mechanisms that enable them to traverse the defenses of the central nervous system (CNS). The ability of HVs to enter a state of latency, a defining characteristic of this viral family, allows them to persist in the human host indefinitely. As such, HVs represent the most frequently detected pathogens in the brain. Read More

    Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6.
    BMC Genomics 2018 03 20;19(1):204. Epub 2018 Mar 20.
    Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.
    Background: Human herpesvirus-6A and -6B (HHV-6) are betaherpesviruses that reach > 90% seroprevalence in the adult population. Unique among human herpesviruses, HHV-6 can integrate into the subtelomeric regions of human chromosomes; when this occurs in germ line cells it causes a condition called inherited chromosomally integrated HHV-6 (iciHHV-6). Only two complete genomes are available for replicating HHV-6B, leading to numerous conflicting annotations and little known about the global genomic diversity of this ubiquitous virus. Read More

    Concomitant Human Herpes Virus 6 and nivolumab-related pneumonitis: Potential pathogenetic insights.
    IDCases 2018 8;11:101-103. Epub 2018 Feb 8.
    2nd Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.
    The development of immune system modulating agents, such as immune checkpoint inhibitors (ICIs), has revolutionized cancer treatment. Nivolumab, a human monoclonal antibody against PD-1, has emerged as an efficient treatment for various malignancies, including non-small cell lung cancer (NSCLC); however, it is associated with important immune related side-effects, attributed to organ-specific inflammation, such as immune-mediated pneumonitis, a relatively uncommon, albeit potentially fatal adverse event. We herein present the unique case of severe interstitial pneumonitis with concomitant detection of Human Herpes Virus 6 (HHV-6) in a nivolumab treated patient with NSCLC. Read More

    Thymidine kinase and protein kinase in drug-resistant herpesviruses: Heads of a Lernaean Hydra.
    Drug Resist Updat 2018 Mar 31;37:1-16. Epub 2018 Jan 31.
    Rega Institute for Medical Research, KU Leuven, Herestraat 49-box 1043, 3000 Leuven, Belgium. Electronic address:
    Herpesviruses thymidine kinase (TK) and protein kinase (PK) allow the activation of nucleoside analogues used in anti-herpesvirus treatments. Mutations emerging in these two genes often lead to emergence of drug-resistant strains responsible for life-threatening diseases in immunocompromised populations. In this review, we analyze the binding of different nucleoside analogues to the TK active site of the three α-herpesviruses [Herpes Simplex Virus 1 and 2 (HSV-1 and HSV-2) and Varicella-Zoster Virus (VZV)] and present the impact of known mutations on the structure of the viral TKs. Read More

    Genomic Integration of HHV-6 Mimicking Viral Reactivation after Autologous Stem Cell Transplantation.
    Mediterr J Hematol Infect Dis 2018 15;10(1):e2018013. Epub 2018 Feb 15.
    Hematology Unit, Humanitas Cancer Center, Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano 20089, Italy.
    The monitoring of Human Herpesvirus 6 (HHV-6) after allogeneic stem cell transplantation has proven to be useful in preventing life-threatening complications; however, the pathogenic role of HHV-6 after autologous transplantation is not well-characterized, although viral reactivation might be responsible for significant complications even after this type of transplant. Here we report, for the first time to our knowledge, the case of a patient with chromosomally integrated HHV-6 (ciHHV-6), presenting with high titers of HHV-6 DNA copies after autologous transplantation, mimicking HHV-6 reactivation. The presence of viral DNA in the follicle bulb confirmed the ciHHV-6 and allowed for the discontinuation of the antiviral treatment. Read More

    Low cytomegalovirus seroprevalence in early multiple sclerosis: a case for the 'hygiene hypothesis'?
    Eur J Neurol 2018 Mar 12. Epub 2018 Mar 12.
    Neurology Department, Hospital del Mar Medical Research Institute (IMIM), Barcelona.
    Background And Purpose: Cytomegalovirus (CMV) infection has recently been associated with a lower multiple sclerosis (MS) susceptibility, although it remains controversial whether it has a protective role or is merely an epiphenomenon related to westernization and early-life viral infections. We aimed to evaluate whether CMV serostatus may differ in patients with early MS as compared with patients with non-early MS, analyzing the putative association of this virus with MS clinical course and humoral immune responses against other herpesviruses.

    Methods: Multicentric analysis was undertaken of 310 patients with MS (early MS, disease duration ≤5 years, n = 127) and controls (n = 155), evaluating specific humoral responses to CMV, Epstein-Barr virus and human herpesvirus-6, as well as T-cell and natural killer (NK)-cell immunophenotypes. Read More

    Human herpesvirus 6A and 6B and NK cells.
    Acta Microbiol Immunol Hung 2018 Mar 7:1-7. Epub 2018 Mar 7.
    1 Department of Medical Sciences, Section of Microbiology, University of Ferrara , Ferrara, Italy.
    Human herpesvirus 6 (HHV-6) comprises two viral species, HHV-6A and HHV-6B, closely related but differing for pathogenic and biological characteristics. Both viral species are predominantly lymphotropic, infecting T lymphocytes and other lymphoid cells, including natural killer (NK) cells. The interactions between HHV-6 and NK cells have been scarcely studied, but it has become clear that NK cells are not only crucial in immune protection during the early phases of infection, but also that HHV-6 infection can affect NK cell functions. Read More

    Viral mimic polyinosine-polycytidylic acid potentiates liver injury in trichloroethylene-sensitized mice - Viral-chemical interaction as a novel mechanism.
    Ecotoxicol Environ Saf 2018 Jul 3;155:101-108. Epub 2018 Mar 3.
    Institute of Dermatology, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230022, China; Department of Occupational and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China. Electronic address:
    Occupational trichloroethylene (TCE) exposure can induce hypersensitivity dermatitis and severe liver injury. Recently, several clinical investigations indicate that viral infection, such as human herpesvirus-6, is associated with hepatic dysfunction in patients with TCE-related generalized skin disorders. However, whether viral infection potentiates TCE-induced liver injury remains unknown. Read More

    Human CD134 (OX40) expressed on T cells plays a key role for human herpesvirus 6B replication after allogeneic hematopoietic stem cell transplantation.
    J Clin Virol 2018 May 21;102:50-55. Epub 2018 Feb 21.
    Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 6500017, Japan. Electronic address:
    Background: CD134 (OX40), which is a cellular receptor for human herpesvirus-6B (HHV-6B) and expresses on activated T cells, may play a key role for HHV-6B replication after allogeneic hematopoietic stem cell transplantation (allo-HSCT).

    Objectives: Therefore, we examined the CD134 expression on T cells and HHV-6B replication after allo-HSCT, and analyzed the correlation between them.

    Study Design: Twenty-three patients after allo-HSCT were enrolled. Read More

    Copy Number Heterogeneity, Large Origin Tandem Repeats, and Interspecies Recombination in Human Herpesvirus 6A (HHV-6A) and HHV-6B Reference Strains.
    J Virol 2018 05 27;92(10). Epub 2018 Apr 27.
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
    Quantitative PCR is a diagnostic pillar for clinical virology testing, and reference materials are necessary for accurate, comparable quantitation between clinical laboratories. Accurate quantitation of human herpesvirus 6A/B (HHV-6A/B) is important for detection of viral reactivation and inherited chromosomally integrated HHV-6A/B in immunocompromised patients. Reference materials in clinical virology commonly consist of laboratory-adapted viral strains that may be affected by the culture process. Read More

    The Not-So-Soft Spot: Pathophysiology of the Bulging Fontanelle in Association With Roseola.
    Pediatr Emerg Care 2018 Feb 28. Epub 2018 Feb 28.
    Roseola infantum is a clinical syndrome characterized by high fever followed by the emergence of a rash. Case reports have documented an association between bulging fontanelles and roseola. We propose a novel mechanism for the development of intracranial hypertension caused by human herpesvirus 6-induced cytokine elevation leading to increased cerebrospinal fluid production. Read More

    Human herpesvirus 6 viremia affects T-cell reconstitution after allogeneic hematopoietic stem cell transplantation.
    Blood Adv 2018 Feb;2(4):428-432
    Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; and.
    Human herpesvirus 6 (HHV6) viremia is a common cause of morbidity following allogeneic hematopoietic cell transplantation (HCT). We previously associated T-cell reconstitution with HHV6 viremia. Here, we investigated whether HHV6 viremia affects T-cell reconstitution after HCT in a time-dependent retrospective analysis. Read More

    Effects of Prophylactic Foscarnet on Human Herpesvirus-6 Reactivation and Encephalitis in Cord Blood Transplant Recipients: A Prospective Multicenter Trial with an Historical Control Group.
    Biol Blood Marrow Transplant 2018 Feb 15. Epub 2018 Feb 15.
    Hematopoietic Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan.
    Cord blood transplantation (CBT) is a distinct risk factor for human herpesvirus-6 (HHV-6) reactivation and HHV-6 encephalitis. In a prospective multicenter trial we investigated the effects of prophylactic foscarnet (90 mg/kg i.v. Read More

    Case 5-2018: A 63-Year-Old Man with Confusion after Stem-Cell Transplantation.
    N Engl J Med 2018 Feb;378(7):659-669
    From the Departments of Medicine (A.R.E.-J., J.B.E.K.), Radiology (P.W.S.), and Pathology (M.M.-L.), Massachusetts General Hospital, and the Departments of Medicine (A.R.E.-J., J.B.E.K.), Radiology (P.W.S.), and Pathology (M.M.-L.), Harvard Medical School - both in Boston.

    Exogenous human herpesvirus 6 reinfection after tumor-infiltrating T-lymphocyte therapy.
    Cytotherapy 2018 Apr 9;20(4):521-523. Epub 2018 Feb 9.
    Laboratory of Virology, University Hospital of Grenoble, Grenoble, France; Institut de Biologie Structurale, CEA, CNRS, Univ. Grenoble Alpes, Grenoble, France. Electronic address:
    Exogenous human herpes virus 6 (HHV-6) reinfection has never been reported in patients receiving tumor-infiltrating T lymphocytes therapy. We report an unusual case of HHV-6 infection following infusion of HHV-6 infected autologous T lymphocytes. HHV-6 infection could interfere with the tumor antigen immune recognition and the efficacy of immunotherapy. Read More

    Malignancy and chemotherapy induced haemophagocytic lymphohistiocytosis in children and adolescents-a single centre experience of 20 years.
    Ann Hematol 2018 Jun 6;97(6):989-998. Epub 2018 Feb 6.
    Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Auenbruggerplatz 34/2, A-8036, Graz, Austria.
    Haemophagocytic lymphohistiocytosis (HLH) is a possibly life-threatening syndrome of immune dysregulation and can be divided into primary (hereditary) and secondary forms (including malignancy-associated HLH (M-HLH)). We retrospectively analysed epidemiological, clinical, virological and laboratory data from patients with M-HLH treated at our department between 1995 and 2014. Out of 1. Read More

    Acute Liver Failure in an Adolescent Male Induced by Human Herpesvirus 6 (HHV-6): A Case Report With Literature Review.
    Lab Med 2018 Mar;49(2):165-174
    Department of Pathology and Laboratory Medicine, Phoenix Children's Hospital, Phoenix, AZ.
    A previously healthy 11-year-old Caucasian boy presented with a 2-week history of nonspecific symptoms of nausea and nonbilious, nonbloody emesis. He developed significant jaundice and hepatic encephalopathy within 1 week of beginning symptoms and was discovered to have fulminant liver failure. Extensive work-ups for underlying etiologies included serologic evaluation for underlying chronic liver diseases, toxicology screening, inborn errors of metabolism, and infectious diseases. Read More


    Fatal outcome after reactivation of inherited chromosomally integrated HHV-6A (iciHHV-6A) transmitted through liver transplantation.
    Am J Transplant 2018 Jan 9. Epub 2018 Jan 9.
    Morphogenèse et Antigénicité du VIH et des Virus des Hépatites Tours, Inserm U1259, Université de Tours, Tours, France.
    HHV-6A and HHV-6B are found as inherited and chromosomally integrated forms (iciHHV-6A and -6B) into all germinal and somatic cells and vertically transmitted in a Mendelian manner in about 1% of the population. They were occasionally shown to be horizontally transmitted through hematopoietic stem cell transplantation. Here, we present a clinical case of horizontal transmission of iciHHV-6A from donor to recipient through liver transplantation. Read More

    Viruses in chronic progressive neurologic disease.
    Mult Scler 2018 Jan;24(1):48-52
    Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
    Viruses have long been implicated as triggers of disease onset and progression in multiple sclerosis (MS) and similar neuroinflammatory disorders. Decades of epidemiological, molecular, and pathologic studies have most strongly linked the human herpesviruses Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6) with MS. However, these viruses are ubiquitous in the general population and typically acquired decades before disease presentation, complicating the study of how they might contribute to disease. Read More

    Evaluation of a method to measure HHV-6B infection in vitro based on cell size.
    Virol J 2018 01 5;15(1). Epub 2018 Jan 5.
    Department of Pathology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA, 01655, USA.
    Background: Human herpesvirus 6 (HHV-6A and HHV-6B) infection of cell cultures can be measured by different methods, including immunofluorescence microscopy, flow cytometry, or quantification of virus DNA by qPCR. These methods are reliable and sensitive but require long processing times and can be costly. Another method used in the field relies on the identification of enlarged cells in the culture; this method requires little sample processing and is relatively fast. Read More

    The impact of alternative donor types on viral infections in pediatric hematopoietic stem cell transplantation.
    Pediatr Transplant 2018 Mar 3;22(2). Epub 2018 Jan 3.
    Department of Pediatric Hematology/Oncology & Bone Marrow Transplantation Unit, School of Medicine, Atakent Hospital, Acıbadem University, Istanbul, Turkey.
    Viral infections remain one of the most important complications following allogeneic HSCT. Few reports compare virus infection between different donor types in pediatric patients. We retrospectively analyzed viral infections and the outcome of one hundred and seventy-one pediatric patients (median 7. Read More

    Summary of the 10th International Conference on Human Herpesviruses-6 and -7 (HHV-6A, -6B, and HHV-7).
    J Med Virol 2018 Apr 4;90(4):625-630. Epub 2018 Jan 4.
    Freie Universität, Berlin, Germany.
    The 10th International Conference on Human herpesviruses-6 and -7 (HHV-6A, HHV-6B, and HHV-7) was held at the Freie Universität, Berlin, Germany from July 23-26, 2017. It attracted more than 130 basic, translational and clinical scientists from 19 countries. Important new information was presented regarding: the biology of HHV-6A and -6B; the biology and epidemiology of inherited chromosomally integrated HHV-6A and -6B; improved diagnostic tests; animal models for and animal viruses with similarities to HHV-6A, -6B, and -7; established and possible disease associations; and new treatment strategies. Read More

    The Neutralizing Linear Epitope of Human Herpesvirus 6A Glycoprotein B Does Not Affect Virus Infectivity.
    J Virol 2018 03 12;92(5). Epub 2018 Feb 12.
    Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan
    Human herpesvirus 6A (HHV-6A) glycoprotein B (gB) is a glycoprotein consisting of 830 amino acids and is essential for the growth of the virus. Previously, we reported that a neutralizing monoclonal antibody (MAb) called 87-y-13 specifically reacts with HHV-6A gB, and we identified its epitope residue at asparagine (Asn) 347 on gB. In this study, we examined whether the epitope recognized by the neutralizing MAb is essential for HHV-6A infection. Read More

    The Interplay between Natural Killer Cells and Human Herpesvirus-6.
    Viruses 2017 12 1;9(12). Epub 2017 Dec 1.
    Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA.
    Human Herpesvirus 6 (HHV-6) is a set of two closely related herpes viruses known as HHV-6A and HHV-6B. Both are lymphotropic viruses that establish latency in the host. The ability to evade the immune responses of effector cells is likely a major factor contributing to the development of a persistent HHV-6A/B (collectively termed HHV-6) infection. Read More

    High human herpesvirus 6 viral load in pediatric allogeneic hematopoietic stem cell transplant patients is associated with detection in end organs and high mortality.
    Pediatr Transplant 2018 Mar 27;22(2). Epub 2017 Nov 27.
    Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
    Human Herpes Virus 6 (HHV-6) reactivation occurs in approximately half of patients following allogeneic hematopoietic stem cell transplant (HSCT). While encephalitis and delayed engraftment are well-documented complications of HHV-6 following HSCT, the extent to which HHV-6 viremia causes disease in children is controversial. We performed a retrospective review of HHV-6 reactivation and possible manifestations in pediatric allogeneic HSCT patients at a single institution. Read More

    No indication of increased infection rates using low-dose alemtuzumab instead of anti-thymocyte globulin as graft-versus-host disease prophylaxis before allogeneic stem cell transplantation.
    Transpl Infect Dis 2018 Feb 27;20(1). Epub 2017 Dec 27.
    Department of Haematology, Oncology, Transplantation, University Medical Centre, Ernst-Moritz-Arndt University, Greifswald, Germany.
    Background: Alemtuzumab as part of the conditioning protocol is effective in reducing graft-versus-host disease (GvHD), but may be associated with increased infection rates, especially when using high doses (ie, 100 mg).

    Methods: We performed a retrospective, single-center, case-control study analyzing the rates of neutropenic fever, cytomegalovirus (CMV) reactivation, Epstein-Barr virus (EBV) reactivation, clinical manifest toxoplasmosis, and clinical manifest human herpesvirus-6 (HHV6) infection using low-dose alemtuzumab in comparison with anti-thymocyte globulin (ATG) as GvHD prophylaxis before allogeneic stem cell transplantation. Forty-four patients transplanted from unrelated donors between 2001 and 2012 were matched by age, diagnosis, and conditioning regimen and treated either with alemtuzumab 10 mg at day -2 (respectively, 20 mg in case of mismatch transplantation) or ATG. Read More

    [How to manage EBV reactivation and EBV-PTLD, CMV and human herpesvirus 6 reactivation and infection after allogeneic stem cell transplantation: A report of the SFGM-TC (update)].
    Bull Cancer 2017 Dec 21;104(12S):S181-S187. Epub 2017 Nov 21.
    Université de Limoges, faculté de médecine, 2, rue du docteur Marcland, 87025 Limoges, France; CHU de Limoges, service de bactériologie virologie-hygiène, 2, avenue Martin-Luther-King, 87042 Limoges, France; Centre national de référence des cytomégalovirus, 87000 Limoges, France; Inserm UMR 1092, 87000 Limoges, France.
    The French society of bone marrow transplantation and cell therapy (SFGM-TC) organizes annually workshops in the attempt to harmonize clinical practices between different francophone transplantation center. Here, we report our recommendations regarding the management of Epstein Barr virus reactivation and lymphoproliferative disorders, cytomegalovirus (CMV) and human herpes virus 6 (HHV6) after allogeneic stem cell transplantation. Read More

    HHV-6A/6B Infection of NK Cells Modulates the Expression of miRNAs and Transcription Factors Potentially Associated to Impaired NK Activity.
    Front Microbiol 2017 31;8:2143. Epub 2017 Oct 31.
    Section of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
    Natural killer (NK) cells have a critical role in controlling virus infections, and viruses have evolved several mechanisms to escape NK cell functions. In particular, Human herpesvirus 6 (HHV-6) is associated with diseases characterized by immune dysregulation and has been reported to infect NK cells. We recently found that HHV-6 infection of human thyroid follicular epithelial cells and T-lymphocytes modulates several miRNAs associated with alterations in immune response. Read More

    Multiple transmissions of chromosomally integrated human herpesvirus-6 in one family.
    Transpl Infect Dis 2018 Feb 16;20(1). Epub 2018 Jan 16.
    Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
    Chromosomally integrated human herpesvirus-6 (ciHHV-6) can be transmitted from parent to child or via allogeneic hematopoietic cell transplantation (HCT). We report a case of ciHHV-6 transmitted via syngeneic HCT, and vertically across 3 generations. ciHHV-6 was transmitted from a parent to the patient and her identical twin, and from the patient to her son. Read More

    Antibody Cross-Reactivity between Porcine Cytomegalovirus (PCMV) and Human Herpesvirus-6 (HHV-6).
    Viruses 2017 10 28;9(11). Epub 2017 Oct 28.
    Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany.
    Porcine cytomegalovirus (PCMV) infection is widely prevalent among pigs, and PCMV is one of the viruses which may be transmitted during xenotransplantation using pig cells, tissues, or organs. While human cytomegalovirus (HCMV) is a major risk factor for allotransplantation, it is still unclear whether PCMV is able to infect human cells or pose a risk for xenotransplantation. Previously, it was shown that transmission of PCMV after pig kidney to non-human primate transplantations resulted in a significantly reduced survival time of the transplanted organ. Read More

    The impact of emergent infections on the fetal state.
    Wiad Lek 2017;70(4):731-736
    Kharkiv National Medical University, Kharkiv, Ukraine.
    The Aim: To study the impact of emergent infections (human herpesvirus type 6) on the fetal state.

    Materials And Methods: The study involved examination of 90 pregnant women in the 2nd and 3rd trimesters of gestation (Group 1 (25 pregnant) consisted of patients with a viral infection, CMV carriers, Group 2 (25 pregnant) included women with a viral infection, herpes simplex virus types 1/2, Group 3 amounted for 20 patients with a viral infection, herpes simplex virus type 6, Group 4 comprised 20 patients with normal pregnancy and no signs of infection. Concentration of IgM and IgG to herpes simplex virus types 1/2, IgM and IgG to herpesvirus type 6 in venous blood of the pregnant was determined by enzyme-immunoassay. Read More

    Analysis of five cases of human herpesvirus-6 myelitis among 121 cord blood transplantations.
    Int J Hematol 2018 Mar 11;107(3):363-372. Epub 2017 Oct 11.
    Department of Hematology, Nagano Red Cross Hospital, Nagano, Japan.
    Reports of myelitis associated with human herpesvirus-6 (HHV-6) following allogeneic transplantation are rare. Of 121 cases of cord blood transplantation (CBT) performed at Nagano Red Cross Hospital, five cases (4.1%) of HHV-6 myelitis developed at around the time of engraftment. Read More

    Fever, rash, and leukopenia in a 32-year-old man · Dx?
    J Fam Pract 2017 Oct;66(10):E7-E10
    Department of Research, Fort Bragg, NC, USA.
    A 32-year-old man was admitted to our hospital with fever, chills, malaise, leukopenia, and a rash. About 3 weeks earlier, he'd had oral maxillofacial surgery and started a 10-day course of prophylactic amoxicillin/clavulanic acid. Fifteen days after the surgery, he developed a fever (temperature, 103° F), chills, arthralgia, myalgia, cough, diarrhea, and malaise. Read More

    [Significance of PCR detection of HHV6 in gastro biopsy on the course of diarrhea in patients with severe diarrhea after allogeneic hematopoietic stem cell transplantation].
    Zhonghua Xue Ye Xue Za Zhi 2017 Aug;38(8):690-694
    Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China.
    To investigate the clinical significance of PCR detection of human herpesvirus 6 (HHV6) in gastro biopsy on the course of diarrhea in patients with severe diarrhea after allogeneic hematopoietic stem cell transplantation (HSCT) . Data from a cohort of 45 HSCT recipients (including age, sex, transplantation conditions, graft-versus-host disease, treatments, clinical signs, outcome, HHV6, and other infections) performed between 2015 and 2016 were collected. Univariate analysis was used to evaluate influences between the different parameters. Read More

    [Latest news on the inherited chromosomally integrated form of human herpesvirus-6 (iciHHV-6)].
    Med Sci (Paris) 2017 Aug-Sep;33(8-9):730-731. Epub 2017 Sep 18.
    Service de virologie, APHP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Université Paris 6, CIMI Paris, équipe « persistent viral infections », Université Paris Descartes; Laboratoire de bactériologie et virologie, Faculté de pharmacie, 83, boulevard de l'Hôpital, 75013 Paris, France.

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