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    3291 results match your criteria Human Herpesvirus Type 6

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    Viruses in chronic progressive neurologic disease.
    Mult Scler 2018 Jan;24(1):48-52
    Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
    Viruses have long been implicated as triggers of disease onset and progression in multiple sclerosis (MS) and similar neuroinflammatory disorders. Decades of epidemiological, molecular, and pathologic studies have most strongly linked the human herpesviruses Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6) with MS. However, these viruses are ubiquitous in the general population and typically acquired decades before disease presentation, complicating the study of how they might contribute to disease. Read More

    Evaluation of a method to measure HHV-6B infection in vitro based on cell size.
    Virol J 2018 Jan 5;15(1). Epub 2018 Jan 5.
    Department of Pathology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA, 01655, USA.
    Background: Human herpesvirus 6 (HHV-6A and HHV-6B) infection of cell cultures can be measured by different methods, including immunofluorescence microscopy, flow cytometry, or quantification of virus DNA by qPCR. These methods are reliable and sensitive but require long processing times and can be costly. Another method used in the field relies on the identification of enlarged cells in the culture; this method requires little sample processing and is relatively fast. Read More

    The impact of alternative donor types on viral infections in pediatric hematopoietic stem cell transplantation.
    Pediatr Transplant 2018 Jan 3. Epub 2018 Jan 3.
    Department of Pediatric Hematology/Oncology & Bone Marrow Transplantation Unit, School of Medicine, Atakent Hospital, Acıbadem University, Istanbul, Turkey.
    Viral infections remain one of the most important complications following allogeneic HSCT. Few reports compare virus infection between different donor types in pediatric patients. We retrospectively analyzed viral infections and the outcome of one hundred and seventy-one pediatric patients (median 7. Read More

    Summary of the 10th International Conference on Human Herpesviruses-6 and -7 (HHV-6A, -6B, and HHV-7).
    J Med Virol 2017 Dec 20. Epub 2017 Dec 20.
    Freie Universität, Berlin, Germany.
    The 10th International Conference on Human herpesviruses-6 and -7 (HHV-6A, HHV-6B, and HHV-7) was held at the Freie Universität, Berlin, Germany from July 23-26, 2017. It attracted more than 130 basic, translational and clinical scientists from 19 countries. Important new information was presented regarding: the biology of HHV-6A and -6B; the biology and epidemiology of inherited chromosomally integrated HHV-6A and -6B; improved diagnostic tests; animal models for and animal viruses with similarities to HHV-6A, -6B, and -7; established and possible disease associations; and new treatment strategies. Read More

    The Interplay between Natural Killer Cells and Human Herpesvirus-6.
    Viruses 2017 Dec 1;9(12). Epub 2017 Dec 1.
    Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA.
    Human Herpesvirus 6 (HHV-6) is a set of two closely related herpes viruses known as HHV-6A and HHV-6B. Both are lymphotropic viruses that establish latency in the host. The ability to evade the immune responses of effector cells is likely a major factor contributing to the development of a persistent HHV-6A/B (collectively termed HHV-6) infection. Read More

    High human herpesvirus 6 viral load in pediatric allogeneic hematopoietic stem cell transplant patients is associated with detection in end organs and high mortality.
    Pediatr Transplant 2017 Nov 27. Epub 2017 Nov 27.
    Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
    Human Herpes Virus 6 (HHV-6) reactivation occurs in approximately half of patients following allogeneic hematopoietic stem cell transplant (HSCT). While encephalitis and delayed engraftment are well-documented complications of HHV-6 following HSCT, the extent to which HHV-6 viremia causes disease in children is controversial. We performed a retrospective review of HHV-6 reactivation and possible manifestations in pediatric allogeneic HSCT patients at a single institution. Read More

    No indication of increased infection rates using low-dose alemtuzumab instead of anti-thymocyte globulin as graft-versus-host disease prophylaxis before allogeneic stem cell transplantation.
    Transpl Infect Dis 2017 Nov 27. Epub 2017 Nov 27.
    Department of Haematology, Oncology, Transplantation, University Medical Centre, Ernst-Moritz-Arndt University, Greifswald, Germany.
    Background: Alemtuzumab as part of the conditioning protocol is effective in reducing graft-versus-host disease (GvHD), but may be associated with increased infection rates, especially when using high doses (ie, 100 mg).

    Methods: We performed a retrospective, single-center, case-control study analyzing the rates of neutropenic fever, cytomegalovirus (CMV) reactivation, Epstein-Barr virus (EBV) reactivation, clinical manifest toxoplasmosis, and clinical manifest human herpesvirus-6 (HHV6) infection using low-dose alemtuzumab in comparison with anti-thymocyte globulin (ATG) as GvHD prophylaxis before allogeneic stem cell transplantation. Forty-four patients transplanted from unrelated donors between 2001 and 2012 were matched by age, diagnosis, and conditioning regimen and treated either with alemtuzumab 10 mg at day -2 (respectively, 20 mg in case of mismatch transplantation) or ATG. Read More

    [How to manage EBV reactivation and EBV-PTLD, CMV and human herpesvirus 6 reactivation and infection after allogeneic stem cell transplantation: A report of the SFGM-TC (update)].
    Bull Cancer 2017 Dec 21;104(12S):S181-S187. Epub 2017 Nov 21.
    Université de Limoges, faculté de médecine, 2, rue du docteur Marcland, 87025 Limoges, France; CHU de Limoges, service de bactériologie virologie-hygiène, 2, avenue Martin-Luther-King, 87042 Limoges, France; Centre national de référence des cytomégalovirus, 87000 Limoges, France; Inserm UMR 1092, 87000 Limoges, France.
    The French society of bone marrow transplantation and cell therapy (SFGM-TC) organizes annually workshops in the attempt to harmonize clinical practices between different francophone transplantation center. Here, we report our recommendations regarding the management of Epstein Barr virus reactivation and lymphoproliferative disorders, cytomegalovirus (CMV) and human herpes virus 6 (HHV6) after allogeneic stem cell transplantation. Read More

    HHV-6A/6B Infection of NK Cells Modulates the Expression of miRNAs and Transcription Factors Potentially Associated to Impaired NK Activity.
    Front Microbiol 2017 31;8:2143. Epub 2017 Oct 31.
    Section of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
    Natural killer (NK) cells have a critical role in controlling virus infections, and viruses have evolved several mechanisms to escape NK cell functions. In particular, Human herpesvirus 6 (HHV-6) is associated with diseases characterized by immune dysregulation and has been reported to infect NK cells. We recently found that HHV-6 in vitro infection of human thyroid follicular epithelial cells and T-lymphocytes modulates several miRNAs associated with alterations in immune response. Read More

    Multiple transmissions of chromosomally integrated human herpesvirus-6 in one family.
    Transpl Infect Dis 2017 Nov 20. Epub 2017 Nov 20.
    Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
    Chromosomally integrated human herpesvirus-6 (ciHHV-6) can be transmitted from parent to child or via allogeneic hematopoietic cell transplantation (HCT). We report a case of ciHHV-6 transmitted via syngeneic HCT, and vertically across three generations. ciHHV-6 was transmitted from a parent to the patient and her identical twin, and from the patient to her son. Read More

    Serum thymus and activation-regulated chemokine (TARC) is associated with the severity of drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome (DRESS/DIHS).
    Br J Dermatol 2017 Nov 18. Epub 2017 Nov 18.
    Department of Dermatology, Nara Medical University School of Medicine, Nara, Japan.
    Drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome (DRESS/DIHS) is a severe adverse drug-induced reaction with reactivation of human herpesvirus 6 (HHV-6).1-3 We previously reported that serum thymus and activation-regulated chemokine (TARC) levels were markedly increased in patients with DIHS and suggested TARC as a useful diagnostic marker of DIHS in the early stage.4,5 In this study, we determined whether serum TARC levels correlate with the severity of clinical symptoms and laboratory data in patients with DRESS/DIHS. Read More

    Antibody Cross-Reactivity between Porcine Cytomegalovirus (PCMV) and Human Herpesvirus-6 (HHV-6).
    Viruses 2017 Oct 28;9(11). Epub 2017 Oct 28.
    Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany.
    Porcine cytomegalovirus (PCMV) infection is widely prevalent among pigs, and PCMV is one of the viruses which may be transmitted during xenotransplantation using pig cells, tissues, or organs. While human cytomegalovirus (HCMV) is a major risk factor for allotransplantation, it is still unclear whether PCMV is able to infect human cells or pose a risk for xenotransplantation. Previously, it was shown that transmission of PCMV after pig kidney to non-human primate transplantations resulted in a significantly reduced survival time of the transplanted organ. Read More

    The impact of emergent infections on the fetal state.
    Wiad Lek 2017;70(4):731-736
    Kharkiv National Medical University, Kharkiv, Ukraine.
    The Aim: To study the impact of emergent infections (human herpesvirus type 6) on the fetal state.

    Materials And Methods: The study involved examination of 90 pregnant women in the 2nd and 3rd trimesters of gestation (Group 1 (25 pregnant) consisted of patients with a viral infection, CMV carriers, Group 2 (25 pregnant) included women with a viral infection, herpes simplex virus types 1/2, Group 3 amounted for 20 patients with a viral infection, herpes simplex virus type 6, Group 4 comprised 20 patients with normal pregnancy and no signs of infection. Concentration of IgM and IgG to herpes simplex virus types 1/2, IgM and IgG to herpesvirus type 6 in venous blood of the pregnant was determined by enzyme-immunoassay. Read More

    Analysis of five cases of human herpesvirus-6 myelitis among 121 cord blood transplantations.
    Int J Hematol 2017 Oct 11. Epub 2017 Oct 11.
    Department of Hematology, Nagano Red Cross Hospital, Nagano, Japan.
    Reports of myelitis associated with human herpesvirus-6 (HHV-6) following allogeneic transplantation are rare. Of 121 cases of cord blood transplantation (CBT) performed at Nagano Red Cross Hospital, five cases (4.1%) of HHV-6 myelitis developed at around the time of engraftment. Read More

    Fever, rash, and leukopenia in a 32-year-old man · Dx?
    J Fam Pract 2017 Oct;66(10):E7-E10
    Department of Research, Fort Bragg, NC, USA.
    A 32-year-old man was admitted to our hospital with fever, chills, malaise, leukopenia, and a rash. About 3 weeks earlier, he'd had oral maxillofacial surgery and started a 10-day course of prophylactic amoxicillin/clavulanic acid. Fifteen days after the surgery, he developed a fever (temperature, 103° F), chills, arthralgia, myalgia, cough, diarrhea, and malaise. Read More

    [Significance of PCR detection of HHV6 in gastro biopsy on the course of diarrhea in patients with severe diarrhea after allogeneic hematopoietic stem cell transplantation].
    Zhonghua Xue Ye Xue Za Zhi 2017 Aug;38(8):690-694
    Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China.
    Objective: To investigate the clinical significance of PCR detection of human herpesvirus 6 (HHV6) in gastro biopsy on the course of diarrhea in patients with severe diarrhea after allogeneic hematopoietic stem cell transplantation (HSCT) . Methods: Data from a cohort of 45 HSCT recipients (including age, sex, transplantation conditions, graft-versus-host disease, treatments, clinical signs, outcome, HHV6, and other infections) performed between 2015 and 2016 were collected. Univariate analysis was used to evaluate influences between the different parameters. Read More

    [Latest news on the inherited chromosomally integrated form of human herpesvirus-6 (iciHHV-6)].
    Med Sci (Paris) 2017 Aug-Sep;33(8-9):730-731. Epub 2017 Sep 18.
    Service de virologie, APHP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Université Paris 6, CIMI Paris, équipe « persistent viral infections », Université Paris Descartes; Laboratoire de bactériologie et virologie, Faculté de pharmacie, 83, boulevard de l'Hôpital, 75013 Paris, France.

    Use of whole genome deep sequencing to define emerging minority variants in virus envelope genes in herpesvirus treated with novel antimicrobial K21.
    Antiviral Res 2017 Oct 19;146:201-204. Epub 2017 Sep 19.
    Department of Pathogen Molecular Biology, London School Hygiene & Tropical Medicine, University of London, UK. Electronic address:
    New antivirals are required to prevent rising antimicrobial resistance from replication inhibitors. The aim of this study was to analyse the range of emerging mutations in herpesvirus by whole genome deep sequencing. We tested human herpesvirus 6 treatment with novel antiviral K21, where evidence indicated distinct effects on virus envelope proteins. Read More

    HLA Haploidentical Stem Cell Transplant with Pretransplant Immunosuppression for Patients with Sickle Cell Disease.
    Biol Blood Marrow Transplant 2018 Jan 20;24(1):185-189. Epub 2017 Sep 20.
    Department of Pediatrics, City of Hope, Duarte, CA.
    Allogeneic stem cell transplantation (HCT) is curative in patients with severe sickle cell disease (SCD), but a significant number of patients lack an HLA-identical sibling or matched unrelated donor. Mismatched related (haploidentical) HCT with post-transplant cyclophosphamide (PTCY) allows expansion of the donor pool but is complicated by high rates of graft failure. In this report we describe a favorable haploidentical HCT approach in a limited cohort of SCD patients with significant comorbidities. Read More

    Persistent Herpesvirus Infections and Telomere Attrition Over 3 Years in the Whitehall II Cohort.
    J Infect Dis 2017 Sep;216(5):565-572
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill.
    The determinants of telomere attrition, a potential marker of cellular aging, are not well understood. Persistent herpesvirus infections including cytomegalovirus (CMV) infection may be particularly important for telomere dynamics via mechanisms such as inflammation, oxidative stress, and their impact on peripheral blood lymphocyte composition. This study examined the association of 4 human herpesviruses (CMV, herpes simplex virus type 1, human herpesvirus type 6, and Epstein-Barr virus) with change in leukocyte telomere length (LTL) over 3 years in 400 healthy individuals (aged 53-76 years) from the Whitehall II cohort. Read More

    Presence of Human Herpesvirus 6B in the Pancreas of Subjects With and Without Type 1 Diabetes.
    Pancreas 2017 Nov/Dec;46(10):1341-1346
    From the Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
    Objectives: The aims of this study were to investigate the presence of human herpesvirus 6 (HHV6) A and B in human pancreata and to search for signs of active infection in this organ of subjects with and without type 1 diabetes (T1D).

    Methods: Pancreata from brain-dead organ donors with and without T1D were examined for the presence of HHV6 genomic sequences by polymerase chain reaction (PCR), transcripts by reverse transcriptase-PCR, and protein by immunohistochemistry. Quantitative PCR of isolated pancreatic islets and exocrine cell clusters was used to determine the intrapancreatic location of HHV6 DNA. Read More

    Human herpesvirus 6-induced inflammatory cardiomyopathy in immunocompetent children.
    Ann Pediatr Cardiol 2017 Sep-Dec;10(3):259-268
    Departement of Pediatrics, UTSW Medical Center, Dallas, TX, USA.
    Over the last decade, human herpesvirus 6 (HHV-6) has been implicated in the etiology of pediatric myocarditis and subsequent dilated cardiomyopathy (DCM). This review provides an overview of recent literature investigating the pathophysiological relevance of HHV-6 in inflammatory cardiomyopathy. We examined 11 cases of previously published pediatric myocarditis and/or DCM associated with HHV-6 and also our experience of detection of virus particles in vascular endothelium of HHV-6 positive endomyocardial biopsy tissue by electron microscopy. Read More

    Viral etiology of sporadic cases of parotitis among children in Korea during 2013-2014.
    J Med Virol 2018 Jan 25;90(1):61-66. Epub 2017 Sep 25.
    Division of Respiratory Viruses, Center for Infectious Diseases, National Institutes of Health, Korea Centers for Disease Control & Prevention, Cheongju-si, Chungbuk, Korea.
    Recent years have seen a high incidence of mumps, which is generally diagnosed based on clinical features, especially parotitis, without laboratory confirmation in Korea. To better understand the epidemiology of mumps in Korean children, we investigated sporadic suspected mumps cases with parotitis. In total, 237 buccal swabs or throat swabs collected from children with parotitis who had been clinically diagnosed with mumps were tested using real-time PCR for the detection of six viruses (Epstein-Barr virus, Human herpesvirus 6, Mumps virus, Human parainfluenza virus-1, -2, -3, Human adenovirus, Human bocavirus). Read More

    Inherited Chromosomally Integrated Human Herpesvirus 6 Genomes Are Ancient, Intact, and Potentially Able To Reactivate from Telomeres.
    J Virol 2017 Nov 27;91(22). Epub 2017 Oct 27.
    Department of Genetics, University of Leicester, Leicester, United Kingdom
    The genomes of human herpesvirus 6A (HHV-6A) and HHV-6B have the capacity to integrate into telomeres, the essential capping structures of chromosomes that play roles in cancer and ageing. About 1% of people worldwide are carriers of chromosomally integrated HHV-6 (ciHHV-6), which is inherited as a genetic trait. Understanding the consequences of integration for the evolution of the viral genome, for the telomere, and for the risk of disease associated with carrier status is hampered by a lack of knowledge about ciHHV-6 genomes. Read More

    Off-the-Shelf Virus-Specific T Cells to Treat BK Virus, Human Herpesvirus 6, Cytomegalovirus, Epstein-Barr Virus, and Adenovirus Infections After Allogeneic Hematopoietic Stem-Cell Transplantation.
    J Clin Oncol 2017 Nov 7;35(31):3547-3557. Epub 2017 Aug 7.
    Ifigeneia Tzannou, Anastasia Papadopoulou, Swati Naik, Kathryn Leung, Caridad A. Martinez, Carlos A. Ramos, George Carrum, Ghadir Sasa, Premal Lulla, Ayumi Watanabe, Manik Kuvalekar, Adrian P. Gee, Bambi J. Grilley, Robert A. Krance, Stephen Gottschalk, Malcolm K. Brenner, Cliona M. Rooney, Helen E. Heslop, Ann M. Leen, and Bilal Omer, Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital; Meng-Fen Wu and Hao Liu, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX.
    Purpose Improvement of cure rates for patients treated with allogeneic hematopoietic stem-cell transplantation (HSCT) will require efforts to decrease treatment-related mortality from severe viral infections. Adoptively transferred virus-specific T cells (VSTs) generated from eligible, third-party donors could provide broad antiviral protection to recipients of HSCT as an immediately available off-the-shelf product. Patient and Methods We generated a bank of VSTs that recognized five common viral pathogens: Epstein-Barr virus (EBV), adenovirus (AdV), cytomegalovirus (CMV), BK virus (BKV), and human herpesvirus 6 (HHV-6). Read More

    Clinical characteristics and outcome of human herpesvirus-6 encephalitis after allogeneic hematopoietic stem cell transplantation.
    Bone Marrow Transplant 2017 Nov 7;52(11):1563-1570. Epub 2017 Aug 7.
    Division of Hematopoietic Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan.
    In this retrospective analysis using the Transplant Registry Unified Management Program, we identified 145 patients with human herpesvirus (HHV)-6 encephalitis among 6593 recipients. The cumulative incidences of HHV-6 encephalitis at 100 days after transplantation in all patients, recipients of bone marrow or PBSCs and recipients of cord blood were 2.3%, 1. Read More

    Human herpesvirus-6 encephalitis following chemotherapy induction for acute myelogenous leukemia.
    Transpl Infect Dis 2017 Dec 25;19(6). Epub 2017 Sep 25.
    Department of Infectious Disease, University of Kansas School of Medicine - Wichita, Wichita, KS, USA.
    We report a case of human herpesvirus-6 (HHV-6) encephalitis in a neutropenic patient who had undergone chemotherapy induction for acute myelogenous leukemia while on broad-spectrum antimicrobial therapy. The patient displayed symptoms of confusion, amnesia, and lethargy. Diagnosis was made via polymerase chain reaction analysis of cerebrospinal fluid. Read More

    Latency, Integration, and Reactivation of Human Herpesvirus-6.
    Viruses 2017 Jul 24;9(7). Epub 2017 Jul 24.
    College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd, MDC Box 7, Tampa, FL 33612, USA.
    Human herpesvirus-6A (HHV-6A) and human herpesvirus-6B (HHV-6B) are two closely related viruses that infect T-cells. Both HHV-6A and HHV-6B possess telomere-like repeats at the terminal regions of their genomes that facilitate latency by integration into the host telomeres, rather than by episome formation. In about 1% of the human population, human herpes virus-6 (HHV-6) integration into germline cells allows the viral genome to be passed down from one generation to the other; this condition is called inherited chromosomally integrated HHV-6 (iciHHV-6). Read More

    Oropharyngeal lesions in pityriasis rosea.
    J Am Acad Dermatol 2017 Nov 18;77(5):833-837.e4. Epub 2017 Jul 18.
    DISSAL Department of Dermatology, IRCCS AOU San Martino-IST, Genoa, Italy.
    Background: Pityriasis rosea (PR) is an exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7). Oropharyngeal lesions may be associated with the exanthema, but anecdotal evidence suggests that few dermatologists are aware of their occurrence.

    Objective: Classifying oropharyngeal lesions in PR, establishing their prevalence, and assessing their possible association with different PR forms. Read More

    Subclinical herpesvirus shedding among HIV-1-infected men on antiretroviral therapy.
    AIDS 2017 Sep;31(15):2085-2094
    aDepartment of Medicine, University of Pittsburgh School of Medicine bDepartment of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health cDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
    Objective: We evaluated the subclinical shedding of six different herpesviruses in antiretroviral drug-treated HIV-positive [HIV(+)] MSM, and determined how this is associated with markers of inflammation and immune activation.

    Methods: We obtained blood, semen, throat washing, urine, and stool from 15 antiretroviral-treated HIV-1-infected MSM with CD4 T-cell reconstitution, and 12 age-matched HIV-negative [HIV (-)] MSM from the Multicenter AIDS Cohort Study at four timepoints over 24 weeks to measure DNA levels of cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus 1 and 2, human herpesvirus 6 (HHV6), and HHV8. T-cell activation and plasma levels of soluble markers of inflammation and activation were also measured at the corresponding timepoints. Read More

    Chromosomally Integrated Human Herpesvirus 6: Models of Viral Genome Release from the Telomere and Impacts on Human Health.
    Viruses 2017 Jul 12;9(7). Epub 2017 Jul 12.
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK.
    Human herpesvirus 6A and 6B, alongside some other herpesviruses, have the striking capacity to integrate into telomeres, the terminal repeated regions of chromosomes. The chromosomally integrated forms, ciHHV-6A and ciHHV-6B, are proposed to be a state of latency and it has been shown that they can both be inherited if integration occurs in the germ line. The first step in full viral reactivation must be the release of the integrated viral genome from the telomere and here we propose various models of this release involving transcription of the viral genome, replication fork collapse, and t-circle mediated release. Read More

    Analysis of the origin of inherited chromosomally integrated human herpesvirus 6 in the Japanese population.
    J Gen Virol 2017 Jul 12;98(7):1823-1830. Epub 2017 Jul 12.
    1​Department of Pediatrics, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
    Integration of the complete human herpesvirus 6 (HHV-6) genome into the telomere of a chromosome has been reported in some individuals (inherited chromosomally integrated HHV-6; iciHHV-6). Since the proportion of iciHHV-6-positive individuals with integration in chromosome 22 is high in Japan, we hypothesized a founder effect. In this study, we sought to elucidate the reason for the high proportion of viral integrations into chromosome 22. Read More

    Co-Infections by Double-Stranded DNA Viruses after Ex Vivo T Cell-Depleted, CD34+ Selected Hematopoietic Cell Transplantation.
    Biol Blood Marrow Transplant 2017 Oct 28;23(10):1759-1766. Epub 2017 Jun 28.
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Medicine, Weill Cornell Medical College, New York, New York. Electronic address:
    Recipients of ex vivo T cell-depleted (TCD) hematopoietic cell transplantation (HCT) are at risk of infection by double-stranded (ds) DNA viruses. We report rates of dsDNA viremia, end-organ disease (EOD), infection-related mortality, and overall survival (OS) in a contemporary cohort of adult TCD HCT recipients routinely monitored for cytomegalovirus (CMV), adenovirus (ADV), human herpesvirus 6 (HHV6), and Epstein-Barr virus (EBV). Healthcare utilization in the first 6 months post-HCT was compared between patients with dsDNA viremia versus no viremia. Read More

    HHV-6 in liver transplantation: A literature review.
    Liver Int 2017 Jun 26. Epub 2017 Jun 26.
    Department of Pediatrics, Transplant Infectious Diseases, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
    Human herpesvirus 6 (HHV-6A and HHV-6B) can cause primary infection or reactivate from latency in liver transplant recipients, which can result in a variety of clinical syndromes, including fever, hepatitis, encephalitis and higher rates of graft dysfunction as well as indirect effects including increased risks of mortality, CMV disease, hepatitis C progression and greater fibrosis scores. Although HHV-6 infection is currently diagnosed by quantifying viral DNA in plasma or blood, biopsy to demonstrate histopathological effects of HHV-6 remains the gold standard for diagnosis of end-organ disease. HHV-6 reactivation may be restricted to the infected organ with no evidence of active infection in the blood. Read More

    Relationship of human herpes virus 6 and multiple sclerosis: A systematic review and meta-analysis.
    J Cell Physiol 2018 Apr 9;233(4):2850-2862. Epub 2017 Oct 9.
    Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Infection with human herpes viruses has been suggested to contribute to multiple sclerosis (MS), while interaction between human herpes 6 (HHV6) and MS remain unclear yet. Here, we conducted a meta-analysis on the relationship of HHV6 infection and MS. All related studies were collected from major databases. Read More

    Impact of stem cell graft on early viral infections and immune reconstitution after allogeneic transplantation in adults.
    J Clin Virol 2017 Aug 31;93:30-36. Epub 2017 May 31.
    Départment d'Hématologie Clinique, CHU de Nantes, Nantes, France; INSERM, U892, CNRS UMR 6299, Université de Nantes, Nantes, France. Electronic address:
    Background: Viral infections are well-known complications after allogeneic stem cell transplant (allo-SCT).

    Objectives: We compared prospectively incidences of DNAemia and active infections (AI) for five opportunistic viruses (Human Herpesvirus 6 (HHV-6), Epstein-Barr virus (EBV), BK polyomavirus (BKPyV), Cytomegalovirus (CMV) and Adenovirus (ADV)) and kinetics of immune reconstitution (IR) in adults receiving either double umbilical cord blood (dUCB group) or unrelated peripheral blood stem cell (uPBSC group) allo-SCT after a reduced-intensity conditioning (RIC) regimen.

    Study Design: Whole blood samples were collected at transplant, every 15days during the first 3 months and at 4, 5 and 6 months post-transplant. Read More

    Outcomes of hematopoietic cell transplantation using donors or recipients with inherited chromosomally integrated HHV-6.
    Blood 2017 08 8;130(8):1062-1069. Epub 2017 Jun 8.
    Department of Medicine, University of Washington, Seattle, WA.
    Human herpesvirus 6 (HHV-6) species have a unique ability to integrate into chromosomal telomeres. Mendelian inheritance via gametocyte integration results in HHV-6 in every nucleated cell. The epidemiology and clinical effect of inherited chromosomally integrated HHV-6 (iciHHV-6) in hematopoietic cell transplant (HCT) recipients is unclear. Read More

    Viral etiologies in adult patients with encephalitis in Poland: A prospective single center study.
    PLoS One 2017 1;12(6):e0178481. Epub 2017 Jun 1.
    Department of Immunopathology of Infectious and Parasitic Diseases, Warsaw Medical University, Warsaw, Poland.
    Encephalitis is a severe neurological syndrome associated with high morbidity and mortality as well as long-term neurological sequelae. Despite being an important public health problem, very few extensive population-based studies were conducted so far in the world and none in Central Europe. Altogether 114 consecutive patients meeting the initial criteria for encephalitis were enrolled at the Warsaw Hospital for Infectious Diseases between June 2012 and July 2015. Read More

    [Evaluation of viral etiology in central nervous system infections from a university hospital point of view in Izmir based on seven years data].
    Mikrobiyol Bul 2017 Apr;51(2):127-135
    Ege University Faculty of Medicine, Department of Medical Microbiology, Izmir, Turkey.
    The serious diseases of the central nervous system (CNS); encephalitis and meningitis, have high mortality and morbidity rate especially not diagnosed and treated in time. Nucleic acid testing (NAT) is the tool of choice for viral diagnosis in CNS infections. In this study, viral etiological agents found in cerebrospinal fluid (CSF) samples sent to our university hospital virology laboratory for laboratory diagnosis of CNS infections were retrospectively evaluated and results were compared with other reports from our country. Read More

    U94 of human herpesvirus 6 down-modulates Src, promotes a partial mesenchymal-to-epithelial transition and inhibits tumor cell growth, invasion and metastasis.
    Oncotarget 2017 Jul;8(27):44533-44549
    Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
    U94, the latency gene of human herpesvirus 6, was found to inhibit migration, invasion and proliferation of vascular endothelial cells (ECs). Because of its potent anti-migratory activity on ECs, we tested the capability of U94 to interfere with the individual steps of the metastatic cascade. We examined the U94 biological activity on the human breast cancer cell line MDA-MB 231, as a model of highly aggressive cancer cell. Read More

    HHV-6 reactivation as a cause of fever in autologous hematopoietic stem cell transplant recipients.
    J Infect 2017 Aug 24;75(2):155-159. Epub 2017 May 24.
    Department of Infectious Diseases, Saint-Louis Hospital, Assistance Publique Hôpitaux de Paris, Paris, France. Electronic address:
    Objectives: We report the biological and clinical impacts possibly associated with HHV-6 reactivation in autologous hematopoietic stem cell transplant (AHSCT) recipients after intensive chemotherapy regimen for lymphoma.

    Methods: We retrospectively reviewed clinical, biological, radiological, treatment and outcomes of patients with positive HHV-6 DNA in whole blood following autologous hematopoietic stem cell transplantation.

    Results: Blood HHV-6 reactivation was reported in 27 (8. Read More

    Development of real-time RT-PCR assays for detection of three classes of HHV-6A gene transcripts.
    J Med Virol 2017 Oct 15;89(10):1830-1836. Epub 2017 Jun 15.
    Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
    Human herpesvirus 6 (HHV-6), a member of the betaherpesvirus family, has two distinct species: HHV-6A and HHV-6B. HHV-6B real-time reverse transcription polymerase chain reaction (RT-PCR) has been used to distinguish between active and latent viral infection. In this study, we developed a real-time RT-PCR assay to detect HHV-6A-specific transcripts and evaluated its reliability for analysis of clinical samples. Read More

    Viruses and endogenous retroviruses in multiple sclerosis: From correlation to causation.
    Acta Neurol Scand 2017 Dec 23;136(6):606-616. Epub 2017 May 23.
    Department of Neurology, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
    Multiple sclerosis is an immune-mediated disease with an environmental component. According to a long-standing but unproven hypothesis dating to initial descriptions of multiple sclerosis (MS) at the end of the 19th century, viruses are either directly or indirectly implicated in MS pathogenesis. Whether viruses in MS are principally causal or simply contributory remains to be proven, but many viruses or viral elements-predominantly Epstein-Barr virus, human endogenous retroviruses (HERVs) and human herpesvirus 6 (HHV-6) but also less common viruses such as Saffold and measles viruses-are associated with MS. Read More

    Hyponatremia associated with human herpesvirus-6 (HHV-6) encephalitis after allogeneic hematopoietic stem cell transplantation: A presentation different from HHV-6 myelitis.
    Int J Hematol 2017 Sep 13;106(3):436-440. Epub 2017 May 13.
    Division of Hematology, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
    Human herpesvirus-6 (HHV-6) encephalitis and myelitis following allogeneic hematopoietic stem cell transplantation (HSCT) is frequently life-threatening. We retrospectively evaluated the clinical significance of hyponatremia in cases of HHV-6 encephalitis/myelitis. Using an institutional database and medical records, we identified and retrospectively analyzed 16 cases of HHV-6 encephalitis and/or myelitis after allogeneic HSCT. Read More

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