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    3233 results match your criteria Human Herpesvirus 6

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    Antibody Cross-Reactivity between Porcine Cytomegalovirus (PCMV) and Human Herpesvirus-6 (HHV-6).
    Viruses 2017 Oct 28;9(11). Epub 2017 Oct 28.
    Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany.
    Porcine cytomegalovirus (PCMV) infection is widely prevalent among pigs, and PCMV is one of the viruses which may be transmitted during xenotransplantation using pig cells, tissues, or organs. While human cytomegalovirus (HCMV) is a major risk factor for allotransplantation, it is still unclear whether PCMV is able to infect human cells or pose a risk for xenotransplantation. Previously, it was shown that transmission of PCMV after pig kidney to non-human primate transplantations resulted in a significantly reduced survival time of the transplanted organ. Read More

    Analysis of five cases of human herpesvirus-6 myelitis among 121 cord blood transplantations.
    Int J Hematol 2017 Oct 11. Epub 2017 Oct 11.
    Department of Hematology, Nagano Red Cross Hospital, Nagano, Japan.
    Reports of myelitis associated with human herpesvirus-6 (HHV-6) following allogeneic transplantation are rare. Of 121 cases of cord blood transplantation (CBT) performed at Nagano Red Cross Hospital, five cases (4.1%) of HHV-6 myelitis developed at around the time of engraftment. Read More

    Fever, rash, and leukopenia in a 32-year-old man · Dx?
    J Fam Pract 2017 Oct;66(10):E7-E10
    Department of Research, Fort Bragg, NC, USA.
    A 32-year-old man was admitted to our hospital with fever, chills, malaise, leukopenia, and a rash. About 3 weeks earlier, he'd had oral maxillofacial surgery and started a 10-day course of prophylactic amoxicillin/clavulanic acid. Fifteen days after the surgery, he developed a fever (temperature, 103° F), chills, arthralgia, myalgia, cough, diarrhea, and malaise. Read More

    [Significance of PCR detection of HHV6 in gastro biopsy on the course of diarrhea in patients with severe diarrhea after allogeneic hematopoietic stem cell transplantation].
    Zhonghua Xue Ye Xue Za Zhi 2017 Aug;38(8):690-694
    Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China.
    Objective: To investigate the clinical significance of PCR detection of human herpesvirus 6 (HHV6) in gastro biopsy on the course of diarrhea in patients with severe diarrhea after allogeneic hematopoietic stem cell transplantation (HSCT) . Methods: Data from a cohort of 45 HSCT recipients (including age, sex, transplantation conditions, graft-versus-host disease, treatments, clinical signs, outcome, HHV6, and other infections) performed between 2015 and 2016 were collected. Univariate analysis was used to evaluate influences between the different parameters. Read More

    [Latest news on the inherited chromosomally integrated form of human herpesvirus-6 (iciHHV-6)].
    Med Sci (Paris) 2017 Aug-Sep;33(8-9):730-731. Epub 2017 Sep 18.
    Service de virologie, APHP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Université Paris 6, CIMI Paris, équipe « persistent viral infections », Université Paris Descartes; Laboratoire de bactériologie et virologie, Faculté de pharmacie, 83, boulevard de l'Hôpital, 75013 Paris, France.

    Use of whole genome deep sequencing to define emerging minority variants in virus envelope genes in herpesvirus treated with novel antimicrobial K21.
    Antiviral Res 2017 Oct 19;146:201-204. Epub 2017 Sep 19.
    Department of Pathogen Molecular Biology, London School Hygiene & Tropical Medicine, University of London, UK. Electronic address:
    New antivirals are required to prevent rising antimicrobial resistance from replication inhibitors. The aim of this study was to analyse the range of emerging mutations in herpesvirus by whole genome deep sequencing. We tested human herpesvirus 6 treatment with novel antiviral K21, where evidence indicated distinct effects on virus envelope proteins. Read More

    HLA Haploidentical Stem Cell Transplant with Pretransplant Immunosuppression for Patients with Sickle Cell Disease.
    Biol Blood Marrow Transplant 2017 Sep 20. Epub 2017 Sep 20.
    Department of Pediatrics, City of Hope, Duarte, CA.
    Allogeneic stem cell transplantation (HCT) is curative in patients with severe sickle cell disease (SCD), but a significant number of patients lack an HLA-identical sibling or matched unrelated donor. Mismatched related (haploidentical) HCT with post-transplant cyclophosphamide (PTCY) allows expansion of the donor pool but is complicated by high rates of graft failure. In this report we describe a favorable haploidentical HCT approach in a limited cohort of SCD patients with significant comorbidities. Read More

    Persistent Herpesvirus Infections and Telomere Attrition Over 3 Years in the Whitehall II Cohort.
    J Infect Dis 2017 Sep;216(5):565-572
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill.
    The determinants of telomere attrition, a potential marker of cellular aging, are not well understood. Persistent herpesvirus infections including cytomegalovirus (CMV) infection may be particularly important for telomere dynamics via mechanisms such as inflammation, oxidative stress, and their impact on peripheral blood lymphocyte composition. This study examined the association of 4 human herpesviruses (CMV, herpes simplex virus type 1, human herpesvirus type 6, and Epstein-Barr virus) with change in leukocyte telomere length (LTL) over 3 years in 400 healthy individuals (aged 53-76 years) from the Whitehall II cohort. Read More

    Presence of Human Herpesvirus 6B in the Pancreas of Subjects With and Without Type 1 Diabetes.
    Pancreas 2017 Nov/Dec;46(10):1341-1346
    From the Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
    Objectives: The aims of this study were to investigate the presence of human herpesvirus 6 (HHV6) A and B in human pancreata and to search for signs of active infection in this organ of subjects with and without type 1 diabetes (T1D).

    Methods: Pancreata from brain-dead organ donors with and without T1D were examined for the presence of HHV6 genomic sequences by polymerase chain reaction (PCR), transcripts by reverse transcriptase-PCR, and protein by immunohistochemistry. Quantitative PCR of isolated pancreatic islets and exocrine cell clusters was used to determine the intrapancreatic location of HHV6 DNA. Read More

    Human herpesvirus 6-induced inflammatory cardiomyopathy in immunocompetent children.
    Ann Pediatr Cardiol 2017 Sep-Dec;10(3):259-268
    Departement of Pediatrics, UTSW Medical Center, Dallas, TX, USA.
    Over the last decade, human herpesvirus 6 (HHV-6) has been implicated in the etiology of pediatric myocarditis and subsequent dilated cardiomyopathy (DCM). This review provides an overview of recent literature investigating the pathophysiological relevance of HHV-6 in inflammatory cardiomyopathy. We examined 11 cases of previously published pediatric myocarditis and/or DCM associated with HHV-6 and also our experience of detection of virus particles in vascular endothelium of HHV-6 positive endomyocardial biopsy tissue by electron microscopy. Read More


    Viral etiology of sporadic cases of parotitis among children in Korea during 2013-2014.
    J Med Virol 2018 Jan 25;90(1):61-66. Epub 2017 Sep 25.
    Division of Respiratory Viruses, Center for Infectious Diseases, National Institutes of Health, Korea Centers for Disease Control & Prevention, Cheongju-si, Chungbuk, Korea.
    Recent years have seen a high incidence of mumps, which is generally diagnosed based on clinical features, especially parotitis, without laboratory confirmation in Korea. To better understand the epidemiology of mumps in Korean children, we investigated sporadic suspected mumps cases with parotitis. In total, 237 buccal swabs or throat swabs collected from children with parotitis who had been clinically diagnosed with mumps were tested using real-time PCR for the detection of six viruses (Epstein-Barr virus, Human herpesvirus 6, Mumps virus, Human parainfluenza virus-1, -2, -3, Human adenovirus, Human bocavirus). Read More

    Inherited Chromosomally Integrated Human Herpesvirus 6 Genomes Are Ancient, Intact, and Potentially Able To Reactivate from Telomeres.
    J Virol 2017 Nov 27;91(22). Epub 2017 Oct 27.
    Department of Genetics, University of Leicester, Leicester, United Kingdom
    The genomes of human herpesvirus 6A (HHV-6A) and HHV-6B have the capacity to integrate into telomeres, the essential capping structures of chromosomes that play roles in cancer and ageing. About 1% of people worldwide are carriers of chromosomally integrated HHV-6 (ciHHV-6), which is inherited as a genetic trait. Understanding the consequences of integration for the evolution of the viral genome, for the telomere, and for the risk of disease associated with carrier status is hampered by a lack of knowledge about ciHHV-6 genomes. Read More

    Off-the-Shelf Virus-Specific T Cells to Treat BK Virus, Human Herpesvirus 6, Cytomegalovirus, Epstein-Barr Virus, and Adenovirus Infections After Allogeneic Hematopoietic Stem-Cell Transplantation.
    J Clin Oncol 2017 Nov 7;35(31):3547-3557. Epub 2017 Aug 7.
    Ifigeneia Tzannou, Anastasia Papadopoulou, Swati Naik, Kathryn Leung, Caridad A. Martinez, Carlos A. Ramos, George Carrum, Ghadir Sasa, Premal Lulla, Ayumi Watanabe, Manik Kuvalekar, Adrian P. Gee, Bambi J. Grilley, Robert A. Krance, Stephen Gottschalk, Malcolm K. Brenner, Cliona M. Rooney, Helen E. Heslop, Ann M. Leen, and Bilal Omer, Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital; Meng-Fen Wu and Hao Liu, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX.
    Purpose Improvement of cure rates for patients treated with allogeneic hematopoietic stem-cell transplantation (HSCT) will require efforts to decrease treatment-related mortality from severe viral infections. Adoptively transferred virus-specific T cells (VSTs) generated from eligible, third-party donors could provide broad antiviral protection to recipients of HSCT as an immediately available off-the-shelf product. Patient and Methods We generated a bank of VSTs that recognized five common viral pathogens: Epstein-Barr virus (EBV), adenovirus (AdV), cytomegalovirus (CMV), BK virus (BKV), and human herpesvirus 6 (HHV-6). Read More

    Clinical characteristics and outcome of human herpesvirus-6 encephalitis after allogeneic hematopoietic stem cell transplantation.
    Bone Marrow Transplant 2017 Nov 7;52(11):1563-1570. Epub 2017 Aug 7.
    Division of Hematopoietic Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan.
    In this retrospective analysis using the Transplant Registry Unified Management Program, we identified 145 patients with human herpesvirus (HHV)-6 encephalitis among 6593 recipients. The cumulative incidences of HHV-6 encephalitis at 100 days after transplantation in all patients, recipients of bone marrow or PBSCs and recipients of cord blood were 2.3%, 1. Read More

    Human herpesvirus-6 encephalitis following chemotherapy induction for acute myelogenous leukemia.
    Transpl Infect Dis 2017 Jul 26. Epub 2017 Jul 26.
    Department of Infectious Disease, University of Kansas School of Medicine - Wichita, Wichita, KS, USA.
    We report a case of human herpesvirus-6 (HHV-6) encephalitis in a neutropenic patient who had undergone chemotherapy induction for acute myelogenous leukemia while on broad-spectrum antimicrobial therapy. The patient displayed symptoms of confusion, amnesia, and lethargy. Diagnosis was made via polymerase chain reaction analysis of cerebrospinal fluid. Read More

    Latency, Integration, and Reactivation of Human Herpesvirus-6.
    Viruses 2017 Jul 24;9(7). Epub 2017 Jul 24.
    College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd, MDC Box 7, Tampa, FL 33612, USA.
    Human herpesvirus-6A (HHV-6A) and human herpesvirus-6B (HHV-6B) are two closely related viruses that infect T-cells. Both HHV-6A and HHV-6B possess telomere-like repeats at the terminal regions of their genomes that facilitate latency by integration into the host telomeres, rather than by episome formation. In about 1% of the human population, human herpes virus-6 (HHV-6) integration into germline cells allows the viral genome to be passed down from one generation to the other; this condition is called inherited chromosomally integrated HHV-6 (iciHHV-6). Read More

    Oropharyngeal lesions in pityriasis rosea.
    J Am Acad Dermatol 2017 Nov 18;77(5):833-837.e4. Epub 2017 Jul 18.
    DISSAL Department of Dermatology, IRCCS AOU San Martino-IST, Genoa, Italy.
    Background: Pityriasis rosea (PR) is an exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7). Oropharyngeal lesions may be associated with the exanthema, but anecdotal evidence suggests that few dermatologists are aware of their occurrence.

    Objective: Classifying oropharyngeal lesions in PR, establishing their prevalence, and assessing their possible association with different PR forms. Read More

    Subclinical herpesvirus shedding among HIV-1-infected men on antiretroviral therapy.
    AIDS 2017 Sep;31(15):2085-2094
    aDepartment of Medicine, University of Pittsburgh School of Medicine bDepartment of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health cDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
    Objective: We evaluated the subclinical shedding of six different herpesviruses in antiretroviral drug-treated HIV-positive [HIV(+)] MSM, and determined how this is associated with markers of inflammation and immune activation.

    Methods: We obtained blood, semen, throat washing, urine, and stool from 15 antiretroviral-treated HIV-1-infected MSM with CD4 T-cell reconstitution, and 12 age-matched HIV-negative [HIV (-)] MSM from the Multicenter AIDS Cohort Study at four timepoints over 24 weeks to measure DNA levels of cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus 1 and 2, human herpesvirus 6 (HHV6), and HHV8. T-cell activation and plasma levels of soluble markers of inflammation and activation were also measured at the corresponding timepoints. Read More

    Chromosomally Integrated Human Herpesvirus 6: Models of Viral Genome Release from the Telomere and Impacts on Human Health.
    Viruses 2017 Jul 12;9(7). Epub 2017 Jul 12.
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK.
    Human herpesvirus 6A and 6B, alongside some other herpesviruses, have the striking capacity to integrate into telomeres, the terminal repeated regions of chromosomes. The chromosomally integrated forms, ciHHV-6A and ciHHV-6B, are proposed to be a state of latency and it has been shown that they can both be inherited if integration occurs in the germ line. The first step in full viral reactivation must be the release of the integrated viral genome from the telomere and here we propose various models of this release involving transcription of the viral genome, replication fork collapse, and t-circle mediated release. Read More

    Analysis of the origin of inherited chromosomally integrated human herpesvirus 6 in the Japanese population.
    J Gen Virol 2017 Jul 12;98(7):1823-1830. Epub 2017 Jul 12.
    1​Department of Pediatrics, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
    Integration of the complete human herpesvirus 6 (HHV-6) genome into the telomere of a chromosome has been reported in some individuals (inherited chromosomally integrated HHV-6; iciHHV-6). Since the proportion of iciHHV-6-positive individuals with integration in chromosome 22 is high in Japan, we hypothesized a founder effect. In this study, we sought to elucidate the reason for the high proportion of viral integrations into chromosome 22. Read More

    Co-Infections by Double-Stranded DNA Viruses after Ex Vivo T Cell-Depleted, CD34(+) Selected Hematopoietic Cell Transplantation.
    Biol Blood Marrow Transplant 2017 Oct 28;23(10):1759-1766. Epub 2017 Jun 28.
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Medicine, Weill Cornell Medical College, New York, New York. Electronic address:
    Recipients of ex vivo T cell-depleted (TCD) hematopoietic cell transplantation (HCT) are at risk of infection by double-stranded (ds) DNA viruses. We report rates of dsDNA viremia, end-organ disease (EOD), infection-related mortality, and overall survival (OS) in a contemporary cohort of adult TCD HCT recipients routinely monitored for cytomegalovirus (CMV), adenovirus (ADV), human herpesvirus 6 (HHV6), and Epstein-Barr virus (EBV). Healthcare utilization in the first 6 months post-HCT was compared between patients with dsDNA viremia versus no viremia. Read More

    HHV-6 in liver transplantation: A literature review.
    Liver Int 2017 Jun 26. Epub 2017 Jun 26.
    Department of Pediatrics, Transplant Infectious Diseases, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
    Human herpesvirus 6 (HHV-6A and HHV-6B) can cause primary infection or reactivate from latency in liver transplant recipients, which can result in a variety of clinical syndromes, including fever, hepatitis, encephalitis and higher rates of graft dysfunction as well as indirect effects including increased risks of mortality, CMV disease, hepatitis C progression and greater fibrosis scores. Although HHV-6 infection is currently diagnosed by quantifying viral DNA in plasma or blood, biopsy to demonstrate histopathological effects of HHV-6 remains the gold standard for diagnosis of end-organ disease. HHV-6 reactivation may be restricted to the infected organ with no evidence of active infection in the blood. Read More

    Relationship of human herpes virus 6 and multiple sclerosis: A systematic review and meta-analysis.
    J Cell Physiol 2017 Jun 20. Epub 2017 Jun 20.
    Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Infection with human herpes viruses has been suggested to contribute to multiple sclerosis (MS), while interaction between human herpes 6 (HHV6) and MS remain unclear yet. Here, we conducted a meta-analysis on the relationship of HHV6 infection and MS. All related studies were collected from major databases. Read More

    Impact of stem cell graft on early viral infections and immune reconstitution after allogeneic transplantation in adults.
    J Clin Virol 2017 Aug 31;93:30-36. Epub 2017 May 31.
    Départment d'Hématologie Clinique, CHU de Nantes, Nantes, France; INSERM, U892, CNRS UMR 6299, Université de Nantes, Nantes, France. Electronic address:
    Background: Viral infections are well-known complications after allogeneic stem cell transplant (allo-SCT).

    Objectives: We compared prospectively incidences of DNAemia and active infections (AI) for five opportunistic viruses (Human Herpesvirus 6 (HHV-6), Epstein-Barr virus (EBV), BK polyomavirus (BKPyV), Cytomegalovirus (CMV) and Adenovirus (ADV)) and kinetics of immune reconstitution (IR) in adults receiving either double umbilical cord blood (dUCB group) or unrelated peripheral blood stem cell (uPBSC group) allo-SCT after a reduced-intensity conditioning (RIC) regimen.

    Study Design: Whole blood samples were collected at transplant, every 15days during the first 3 months and at 4, 5 and 6 months post-transplant. Read More

    Outcomes of hematopoietic cell transplantation using donors or recipients with inherited chromosomally integrated HHV-6.
    Blood 2017 Aug 8;130(8):1062-1069. Epub 2017 Jun 8.
    Department of Medicine, University of Washington, Seattle, WA.
    Human herpesvirus 6 (HHV-6) species have a unique ability to integrate into chromosomal telomeres. Mendelian inheritance via gametocyte integration results in HHV-6 in every nucleated cell. The epidemiology and clinical effect of inherited chromosomally integrated HHV-6 (iciHHV-6) in hematopoietic cell transplant (HCT) recipients is unclear. Read More

    Viral etiologies in adult patients with encephalitis in Poland: A prospective single center study.
    PLoS One 2017 1;12(6):e0178481. Epub 2017 Jun 1.
    Department of Immunopathology of Infectious and Parasitic Diseases, Warsaw Medical University, Warsaw, Poland.
    Encephalitis is a severe neurological syndrome associated with high morbidity and mortality as well as long-term neurological sequelae. Despite being an important public health problem, very few extensive population-based studies were conducted so far in the world and none in Central Europe. Altogether 114 consecutive patients meeting the initial criteria for encephalitis were enrolled at the Warsaw Hospital for Infectious Diseases between June 2012 and July 2015. Read More

    [Evaluation of viral etiology in central nervous system infections from a university hospital point of view in Izmir based on seven years data].
    Mikrobiyol Bul 2017 Apr;51(2):127-135
    Ege University Faculty of Medicine, Department of Medical Microbiology, Izmir, Turkey.
    The serious diseases of the central nervous system (CNS); encephalitis and meningitis, have high mortality and morbidity rate especially not diagnosed and treated in time. Nucleic acid testing (NAT) is the tool of choice for viral diagnosis in CNS infections. In this study, viral etiological agents found in cerebrospinal fluid (CSF) samples sent to our university hospital virology laboratory for laboratory diagnosis of CNS infections were retrospectively evaluated and results were compared with other reports from our country. Read More

    U94 of human herpesvirus 6 down-modulates Src, promotes a partial mesenchymal-to-epithelial transition and inhibits tumor cell growth, invasion and metastasis.
    Oncotarget 2017 Jul;8(27):44533-44549
    Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
    U94, the latency gene of human herpesvirus 6, was found to inhibit migration, invasion and proliferation of vascular endothelial cells (ECs). Because of its potent anti-migratory activity on ECs, we tested the capability of U94 to interfere with the individual steps of the metastatic cascade. We examined the U94 biological activity on the human breast cancer cell line MDA-MB 231, as a model of highly aggressive cancer cell. Read More

    HHV-6 reactivation as a cause of fever in autologous hematopoietic stem cell transplant recipients.
    J Infect 2017 Aug 24;75(2):155-159. Epub 2017 May 24.
    Department of Infectious Diseases, Saint-Louis Hospital, Assistance Publique Hôpitaux de Paris, Paris, France. Electronic address:
    Objectives: We report the biological and clinical impacts possibly associated with HHV-6 reactivation in autologous hematopoietic stem cell transplant (AHSCT) recipients after intensive chemotherapy regimen for lymphoma.

    Methods: We retrospectively reviewed clinical, biological, radiological, treatment and outcomes of patients with positive HHV-6 DNA in whole blood following autologous hematopoietic stem cell transplantation.

    Results: Blood HHV-6 reactivation was reported in 27 (8. Read More

    Development of real-time RT-PCR assays for detection of three classes of HHV-6A gene transcripts.
    J Med Virol 2017 Oct 15;89(10):1830-1836. Epub 2017 Jun 15.
    Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
    Human herpesvirus 6 (HHV-6), a member of the betaherpesvirus family, has two distinct species: HHV-6A and HHV-6B. HHV-6B real-time reverse transcription polymerase chain reaction (RT-PCR) has been used to distinguish between active and latent viral infection. In this study, we developed a real-time RT-PCR assay to detect HHV-6A-specific transcripts and evaluated its reliability for analysis of clinical samples. Read More

    Viruses and endogenous retroviruses in multiple sclerosis: From correlation to causation.
    Acta Neurol Scand 2017 Dec 23;136(6):606-616. Epub 2017 May 23.
    Department of Neurology, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
    Multiple sclerosis is an immune-mediated disease with an environmental component. According to a long-standing but unproven hypothesis dating to initial descriptions of multiple sclerosis (MS) at the end of the 19th century, viruses are either directly or indirectly implicated in MS pathogenesis. Whether viruses in MS are principally causal or simply contributory remains to be proven, but many viruses or viral elements-predominantly Epstein-Barr virus, human endogenous retroviruses (HERVs) and human herpesvirus 6 (HHV-6) but also less common viruses such as Saffold and measles viruses-are associated with MS. Read More

    Hyponatremia associated with human herpesvirus-6 (HHV-6) encephalitis after allogeneic hematopoietic stem cell transplantation: A presentation different from HHV-6 myelitis.
    Int J Hematol 2017 May 13. Epub 2017 May 13.
    Division of Hematology, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
    Human herpesvirus-6 (HHV-6) encephalitis and myelitis following allogeneic hematopoietic stem cell transplantation (HSCT) is frequently life-threatening. We retrospectively evaluated the clinical significance of hyponatremia in cases of HHV-6 encephalitis/myelitis. Using an institutional database and medical records, we identified and retrospectively analyzed 16 cases of HHV-6 encephalitis and/or myelitis after allogeneic HSCT. Read More

    The use of heparin in infertility and recurrent pregnancy loss: Are its antiviral properties at play?
    Med Hypotheses 2017 May 6;102:41-47. Epub 2017 Mar 6.
    Department of Medical Sciences, Microbiology, University of Ferrara, Italy.
    Recently, human herpesvirus 6 (HHV-6) has been implicated in cases of poor pregnancy outcomes. The ability of HHV-6 to disrupt endothelial cell functioning may inhibit the creation of an appropriate uterine environment for implantation and fetal development, resulting in infertility and pregnancy loss, among other complications. Heparin has been used to treat pregnant women who are predisposed to thrombosis, and it has also been used in some women with infertility or recurrent pregnancy loss without associated thrombotic events. Read More

    Human Herpesvirus 6 (HHV-6) necrotizing encephalitis, a rare condition in immunocompromised patients: The importance of brain biopsy associated with HHV-6 testing.
    J Neurol Sci 2017 Jun 6;377:112-115. Epub 2017 Apr 6.
    Neurological Intensive Care Unit, Neurology Department, Assistance Publique-Hôpitaux de Paris, Universitary Hospital La Pitié Salpêtrière-Charles Foix, and Sorbonne Universités, Pierre and Marie Curie University, Paris, France.

    Comparative evaluation of a laboratory developed real-time PCR assay and the RealStar(®) HHV-6 PCR Kit for quantitative detection of human herpesvirus 6.
    J Virol Methods 2017 Aug 2;246:112-116. Epub 2017 May 2.
    Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region; Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region; The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address:
    Background: HHV-6 reactivation in immunocompromised patients is common and may be associated with serious morbidity and mortality; therefore, early detection and initiation of therapy might be of benefit. Real-time PCR assays allow for early identification of HHV-6 reactivation to assist in providing a timely response. Thus, we compared the performance of an in-house developed HHV-6 quantitative PCR assay with a commercially available kit, the RealStar(®) HHV-6 PCR Kit. Read More

    Characterizing the Cellular Immune Response to Parainfluenza Virus 3.
    J Infect Dis 2017 Jul;216(2):153-161
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital.
    Parainfluenza virus type 3 (PIV3) infections are a major cause of morbidity and mortality in immunocompromised individuals, with no approved therapies. Our group has demonstrated the safety and efficacy of adoptively transferred virus-specific T cells for the prevention and treatment of a broad range of viral infections including BK virus, cytomegalovirus, adenovirus, human herpesvirus 6, and Epstein-Barr virus. However, this approach is restricted to well-characterized viruses with known immunogenic/protective T-cell target antigens, precluding extension to PIV3. Read More

    Molecular diagnosis of central nervous system opportunistic infections and mortality in HIV-infected adults in Central China.
    AIDS Res Ther 2017 2;14:24. Epub 2017 May 2.
    Basic Medical College of Wuhan University, Wuhan, China.
    Background: CSF PCR is the standard diagnostic technique used in resource-rich settings to detect pathogens of the CNS infection. However, it is not currently used for routine CSF testing in China. Knowledge of CNS opportunistic infections among people living with HIV in China is limited. Read More

    Stabilization of Telomere G-Quadruplexes Interferes with Human Herpesvirus 6A Chromosomal Integration.
    J Virol 2017 Jul 26;91(14). Epub 2017 Jun 26.
    Division of Infectious and Immune Diseases, CHU de Québec Research Center, Quebec City, Quebec, Canada
    Human herpesviruses 6A and 6B (HHV-6A/B) can integrate their genomes into the telomeres of human chromosomes using a mechanism that remains poorly understood. To achieve a better understanding of the HHV-6A/B integration mechanism, we made use of BRACO-19, a compound that stabilizes G-quadruplex secondary structures and prevents telomere elongation by the telomerase complex. First, we analyzed the folding of telomeric sequences into G-quadruplex structures and their binding to BRACO-19 using G-quadruplex-specific antibodies and surface plasmon resonance. Read More

    Cell Culture Systems To Study Human Herpesvirus 6A/B Chromosomal Integration.
    J Virol 2017 Jul 26;91(14). Epub 2017 Jun 26.
    Division of Infectious and Immune Diseases, CHU de Quebec Research Center, Quebec City, Canada
    Human herpesviruses 6A/B (HHV-6A/B) can integrate their viral genomes in the telomeres of human chromosomes. The viral and cellular factors contributing to HHV-6A/B integration remain largely unknown, mostly due to the lack of efficient and reproducible cell culture models to study HHV-6A/B integration. In this study, we characterized the HHV-6A/B integration efficiencies in several human cell lines using two different approaches. Read More

    Predictive value of clinical and laboratory features for the main febrile diseases in children living in Tanzania: A prospective observational study.
    PLoS One 2017 2;12(5):e0173314. Epub 2017 May 2.
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland.
    Background: To construct evidence-based guidelines for management of febrile illness, it is essential to identify clinical predictors for the main causes of fever, either to diagnose the disease when no laboratory test is available or to better target testing when a test is available. The objective was to investigate clinical predictors of several diseases in a cohort of febrile children attending outpatient clinics in Tanzania, whose diagnoses have been established after extensive clinical and laboratory workup.

    Method: From April to December 2008, 1005 consecutive children aged 2 months to 10 years with temperature ≥38°C attending two outpatient clinics in Dar es Salaam were included. Read More

    Herpesviruses hijack host exosomes for viral pathogenesis.
    Semin Cell Dev Biol 2017 Jul 26;67:91-100. Epub 2017 Apr 26.
    Infection and Immunity Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia. Electronic address:
    Herpesviruses are remarkable pathogens possessing elaborate mechanisms to seize various host cellular components for immune evasion, replication, and virion egress. As viruses are dependent upon their hosts, investigating this intricate interplay has revealed that the exosome pathway is utilised by alpha (Herpes Simplex Virus 1), beta (Human Cytomegalovirus, and Human Herpesvirus 6) and gamma (Epstein-Barr Virus, and Kaposi Sarcoma-associated Herpesvirus) herpesviruses. Virions and exosomes share similar properties and functions. Read More

    Kidney transplant after hematopoietic cell transplant in pediatrics: Infectious and immunosuppressive considerations.
    Pediatr Transplant 2017 Aug 27;21(5). Epub 2017 Apr 27.
    Department of Pediatrics, Division of Nephrology, University of Minnesota, Minneapolis, MN, USA.
    Pediatric patients requiring kidney transplant after hematopoietic cell transplant receive multiple courses of immunosuppression placing them at risk for infection. To elucidate potential risk factors for infection, we compared the immunosuppressive regimens and infectious complications of pediatric kidney transplant recipients at a single institution who had previously undergone hematopoietic cell transplant from different donors to similar patients reported in the literature. Among the initial four post-hematopoietic cell transplant kidney transplant patients reviewed, viremia episodes were universal, including BK virus, Epstein-Barr virus, and human herpesvirus-6, with one death from presumed BK virus encephalitis. Read More

    Variation within MBP gene predicts disease course in multiple sclerosis.
    Brain Behav 2017 Apr 9;7(4):e00670. Epub 2017 Mar 9.
    Menzies Institute for Medical ResearchUniversity of TasmaniaHobartTASAustralia.
    Objective: Prognosis following a first demyelinating event is difficult to predict, with no genetic markers of MS progression currently identified. Myelin basic protein (MBP) is a major component of the myelin sheath of CNS neurons and may play a central role in demyelinating diseases such as MS. However, genetic variation in MBP has not been implicated in MS onset risk in large genome-wide association studies. Read More

    A Histological Study of Fulminant Type 1 Diabetes Mellitus Related to Human Cytomegalovirus Reactivation.
    J Clin Endocrinol Metab 2017 Jul;102(7):2394-2400
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita "565-0871", Japan.
    Context: Fulminant type 1 diabetes mellitus (T1DM) is thought to be partly caused by virus infection.

    Objective: This study investigated the mechanism of β cell destruction in fulminant T1DM after drug-induced hypersensitivity syndrome (DIHS).

    Methods: We determined the localization of human cytomegalovirus (HCMV), human herpesvirus 6 (HHV-6), and Epstein-Barr virus (EBV) and the expression of interferon regulatory factor 3 (IRF3) and viral receptors of Z-DNA binding protein 1 (ZBP1) and retinoic acid-inducible gene I (RIG-I), together with inflammatory cells, by immunohistochemistry of the autopsy pancreas of a patient with fulminant T1DM with DIHS and in seven subjects with normal glucose tolerance who underwent pancreatectomy. Read More

    Viral reactivations and associated outcomes in the context of immune reconstitution after pediatric hematopoietic cell transplantation.
    J Allergy Clin Immunol 2017 Apr 7. Epub 2017 Apr 7.
    Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands; Pediatric Blood and Marrow Transplantation Program, University Medical Centre Utrecht, Utrecht, The Netherlands. Electronic address:
    Background: Viral reactivations (VRs) after hematopoietic cell transplantation (HCT) contribute to significant morbidity and mortality. Timely immune reconstitution (IR) is suggested to prevent VR.

    Objectives: We studied the relation between IR (as a continuous predictor over time) and VR (as a time-varying predictor) and the relation between VR and other clinical outcomes. Read More

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