933 results match your criteria Human Fertility[Journal]


A prospective study of C-reactive protein in patients with obesity during IVF.

Hum Fertil (Camb) 2019 Apr 23:1-6. Epub 2019 Apr 23.

a IVF Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, affiliated with the Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.

This prospective cohort pilot study investigated the physiology of C-reactive protein (CRP) during in vitro fertilization (IVF) cycles and its effect on outcomes in women with and without obesity. The study was conducted from April to August 2014, in the IVF Unit of a university-affiliated hospital. Women aged 18-42 years were enrolled. Read More

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http://dx.doi.org/10.1080/14647273.2019.1605459DOI Listing

Investigating attitudes towards oocyte donation amongst potential donors and the general population: a systematic review.

Hum Fertil (Camb) 2019 Apr 15:1-13. Epub 2019 Apr 15.

d Lister Hospital , London , UK.

With a current shortage of oocyte donors in the United Kingdom (UK), the psychological factors determining intentions to donate oocytes are important to understand. The objectives of this review were to explore psychosocial aspects of potential oocyte donors, including attitudes, motivations, as well as any issues surrounding potential donor disclosure and anonymity. A systematic search of English peer-reviewed journals of three computerized databases following PRISMA guidelines was conducted. Read More

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https://www.tandfonline.com/doi/full/10.1080/14647273.2019.1
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http://dx.doi.org/10.1080/14647273.2019.1602736DOI Listing
April 2019
1 Read

Growing on (in)fertile ground: an evolutionary concept analysis of Black female fertility.

Hum Fertil (Camb) 2019 Apr 12:1-9. Epub 2019 Apr 12.

a Duke University School of Nursing , Durham , NC , USA.

Female fertility is a complex phenomenon. Biological, personal, social and political factors shape this experience. Race, a social construction, was created to justify discriminative political and economic practices. Read More

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https://www.tandfonline.com/doi/full/10.1080/14647273.2019.1
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http://dx.doi.org/10.1080/14647273.2019.1601269DOI Listing
April 2019
4 Reads

Time-lapse videography for embryo selection/de-selection: a bright future or fading star?

Hum Fertil (Camb) 2019 Apr 9:1-7. Epub 2019 Apr 9.

b School of Medical and Health Sciences , Edith Cowan University , Joondalup , Australia.

The recent clinical introduction of time-lapse videography into in vitro fertilization laboratories has offered a novel opportunity for embryologists to explore improved methods for embryo selection. While the concept of uninterrupted culture of embryos provided by such systems is welcomed, the current evidence does not support its full application in routine clinical practice. The issue of whether or not algorithms for embryo selection can be extrapolated between laboratories, which may represent a major hurdle to its wide application, is currently gaining increasing attention amongst embryologists worldwide. Read More

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https://www.tandfonline.com/doi/full/10.1080/14647273.2019.1
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http://dx.doi.org/10.1080/14647273.2019.1598586DOI Listing
April 2019
1 Read

Recommendations for good practice for sedation in assisted conception.

Hum Fertil (Camb) 2019 Apr 3:1-9. Epub 2019 Apr 3.

c Department of Anaesthesia , Derriford Hospital , Plymouth , UK.

Conscious sedation is a commonly used approach to provide pain relief during transvaginal oocyte retrieval. It has been shown to be effective with high levels of acceptability and patient satisfaction. Fundamental Standards and Development Standards in safe sedation practice have been set out by the Royal College of Anaesthetists and they recommend that Royal Colleges, in association with the relevant sub-specialty organizations, should develop guidelines on sedation methods appropriate to clinical practice in their sphere of influence. Read More

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http://dx.doi.org/10.1080/14647273.2019.1596245DOI Listing

Exposure to traumatic events, emotion regulation, and traumatic stress among infertility patients: a moderation analysis.

Hum Fertil (Camb) 2019 Apr 2:1-8. Epub 2019 Apr 2.

b Psychology , University of South Dakota , Vermillion , SD , USA.

Exposure to traumatic events and emotion regulation were examined as predictors of posttraumatic stress symptoms (PTSS) among women seeking medical treatment for infertility. Emotion regulation difficulties were hypothesized to moderate the association between traumatic events and PTSS severity. Sixty-six participants completed the Trauma History Questionnaire, Posttraumatic Check List for DSM-5, and Difficulties in Emotion Regulation Scale. Read More

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http://dx.doi.org/10.1080/14647273.2019.1593517DOI Listing

Should the current guidelines for the treatment of varicoceles in infertile men be re-evaluated?

Hum Fertil (Camb) 2019 Mar 23:1-15. Epub 2019 Mar 23.

c Department of Men's Health and Andrology , Imperial College Healthcare , London , UK.

Male infertility is a major health burden worldwide. In the United Kingdom, the diagnostic and treatment pathway for male factor fertility is fragmented with wide variance in management and funding protocols. There is now a focus on potential overtreatment of couples with IVF and failure to treat male factors before considering assisted reproductive technology (ART). Read More

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http://dx.doi.org/10.1080/14647273.2019.1582807DOI Listing

British Fertility Society.

Authors:

Hum Fertil (Camb) 2019 Apr;22(1):68-75

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http://dx.doi.org/10.1080/14647273.2019.1578102DOI Listing

Volume 22 is here!

Authors:
Allan A Pacey

Hum Fertil (Camb) 2019 Apr;22(1)

a Academic Unit of Reproductive and Developmental Medicine, Department of Oncology and Metabolism , School of Medicine and Biomedical Sciences, University of Sheffield , The Jessop Wing, Sheffield , S10 2SF , UK.

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http://dx.doi.org/10.1080/14647273.2019.1589011DOI Listing

Feasibility and acceptability of theatrical and visual art to deliver fertility education to young adults.

Hum Fertil (Camb) 2019 Mar 1:1-7. Epub 2019 Mar 1.

d School of Psychology, Cardiff University , Cardiff , UK.

The Fertility Education Initiative was established in 2016 to provide education on fertility, modern families and reproductive science for young adults, teachers, health professionals, parents and adults. We report on our study to determine the feasibility and acceptability of using the arts to delivery fertility education in schools. The evaluation was mixed methods: (i) two focus groups with young people aged 14-16 and 16-18 were conducted to investigate attitudes to fertility awareness; and (ii) seventeen 16-22 year olds were divided into two groups and each undertook a day of art workshops that consisted of two visual and two theatrical workshops and then completed questionnaires at the end of each workshop and at the end of the day. Read More

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http://dx.doi.org/10.1080/14647273.2019.1570354DOI Listing
March 2019
1 Read

The effect of maternal body mass index (BMI) and telomere function on in vitro fertilization (IVF) outcome: a preliminary cohort study.

Hum Fertil (Camb) 2019 Feb 17:1-7. Epub 2019 Feb 17.

b Sackler School of Medicine , Tel Aviv University , Tel Aviv , Israel.

Telomeres are a specific base sequence of DNA, responsible for chromosome stability and DNA protection. We aimed to investigate the association between telomere systems and IVF outcomes according to patients' BMI. For all telomere characteristics, there was a distinct trend towards shorter telomeres and activation of telomere shortening compensatory mechanisms in the BMI group >25kg/m, reaching statistical significance for senescence only (r = 0. Read More

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http://dx.doi.org/10.1080/14647273.2019.1575988DOI Listing
February 2019

Oocyte donation disclosure decisions: a longitudinal follow-up at middle childhood.

Hum Fertil (Camb) 2019 Feb 6:1-15. Epub 2019 Feb 6.

e Departments of Obstetrics and Gynecology and Psychiatry and Behavioral Sciences , Northwestern University Feinberg School of Medicine , Chicago , IL , USA.

Few studies have captured oocyte donation (OD) parents' decision processes about intended and actual disclosure over time. Likewise, OD children's perceptions about their family composition during middle childhood are underexplored. To address these gaps, a longitudinally followed cohort of OD recipient families was invited to participate in a qualitative, follow-up study. Read More

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http://dx.doi.org/10.1080/14647273.2019.1567945DOI Listing
February 2019

Association of IL-17 and IL-23 follicular fluid concentrations and gene expression profile in cumulus cells from infertile women at risk for ovarian hyperstimulation syndrome.

Hum Fertil (Camb) 2019 Feb 4:1-7. Epub 2019 Feb 4.

d Department of Immunology , Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences , Yazd , Iran.

This study determined the association between the levels of interleukin (IL)-17 and IL-23 in follicular fluid (FF), as well as their mRNA levels in cumulus cells from infertile women at risk for ovarian hyperstimulation syndrome (OHSS). In this case-controlled study, the control group (n = 40) was infertile women whose partners had male factor infertility, whereas the case group (n = 40) was infertile women at risk of OHSS. IL-17 and IL-23 concentrations in FF were measured using an enzyme-linked immunosorbent assay method, whereas the mRNA expression levels of IL-17 and IL-23 of cumulus cells were determined using RT-PCR. Read More

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http://dx.doi.org/10.1080/14647273.2019.1566648DOI Listing
February 2019
3 Reads
1.018 Impact Factor

The effects of autologous platelet-rich plasma in repeated implantation failure: a randomized controlled trial.

Hum Fertil (Camb) 2019 Feb 4:1-5. Epub 2019 Feb 4.

a Department of Obstetrics and Gynecology , Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Repeated implantation failure is a major challenge in reproductive medicine and despite several methods that have been described for management, there is little consensus on which is the most effective. This study was conducted to evaluate the effectiveness of autologous platelet-rich plasma in improving the pregnancy rate in repeated implantation failure. Between 2016 and 2017, a total of 138 patients who failed to conceive after 3 or more embryo transfers with high quality embryos and candidate for frozen-thawed embryo transfer were assessed for eligibility to enter the study. Read More

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http://dx.doi.org/10.1080/14647273.2019.1569268DOI Listing
February 2019
3 Reads

Association of ICAM-1 gene variant rs5498 (1462A>G) with non-obstructive azoospermia.

Hum Fertil (Camb) 2019 Feb 1:1-5. Epub 2019 Feb 1.

c Department of Andrology and Dermatology, Faculty of Medicine , Suez Canal University , Ismailia , Egypt.

The blood testicular barrier (BTB) is a barrier protecting the testes from damage. It also plays an important role in spermatogenesis. The intracellular adhesion molecule-1 (ICAM-1) is a member of the immunoglobulin cell adhesion molecule family and is a constituent component of the BTB. Read More

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http://dx.doi.org/10.1080/14647273.2019.1566646DOI Listing
February 2019

Luteal oestradiol for patients with serum oestradiol levels lower than expected per oocyte.

Hum Fertil (Camb) 2019 Jan 29:1-7. Epub 2019 Jan 29.

a Department of Obstetrics and Gynecology , Uludag University School of Medicine , Bursa , Turkish Republic.

Although the efficiency of progesterone in providing luteal phase support has been established, the role of oestradiol supplementation during the luteal phase remains controversial. We evaluated pregnancy outcomes of patients who had a ratio of serum E2 levels on the hCG day to the number of oocytes retrieved (oestradiol/oocyte ratio - EOR) levels of <100 pg/ml by supporting them with additional oestradiol during the luteal phase. In total, 150 patients with an EOR < 100 pg/ml of oestradiol undergoing antagonist intracytoplasmic sperm injection (ICSI) cycles were randomly assigned into two groups to receive either oral oestradiol (4 mg/d) plus vaginal progesterone (90 mg, 2 × 1/day) (group 1) or vaginal progesterone (90 mg, 2 × 1/d) alone (group 2). Read More

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http://dx.doi.org/10.1080/14647273.2019.1566647DOI Listing
January 2019
1 Read

Anonymous Dutch sperm donors releasing their identity.

Hum Fertil (Camb) 2019 Jan 17:1-7. Epub 2019 Jan 17.

a Fiom , 's-Hertogenbosch , the Netherlands.

This study examined the motivations of anonymous Dutch sperm donors to release their identity. It aimed to increase knowledge and encourage donors to become identifiable through a more informed decision, allowing more donor-conceived persons to contact their donors. Since 2010, anonymous sperm donors in the Netherlands can register in the Fiom KID-DNA Database developed by Fiom and Canisius Wilhelmina Hospital (CWZ). Read More

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https://www.tandfonline.com/doi/full/10.1080/14647273.2018.1
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http://dx.doi.org/10.1080/14647273.2018.1564156DOI Listing
January 2019
10 Reads

Can the ethnic differences in IVF cycle outcome be influenced by the impact of BMI?

Hum Fertil (Camb) 2019 Jan 14:1-7. Epub 2019 Jan 14.

a Leeds Fertility, Leeds Teaching Hospital NHS Trust , Leeds , UK.

The objective of this study was to investigate the role of Body Mass Index (BMI) in influencing ethnic variation in IVF outcomes. This retrospective cohort study included women (having BMI between 19 to 30 kg/m) undergoing their first IVF cycle with fresh blastocyst transfer at a single IVF unit between 2010 and 2015. In summary, South Asian women had a lower live birth rate (LBR) (27% vs 44. Read More

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http://dx.doi.org/10.1080/14647273.2018.1563915DOI Listing
January 2019
1 Read

Is azoospermia the appropriate standard for post-vasectomy semen analysis? Or an unachievable goal of best practice laboratory guidelines.

Hum Fertil (Camb) 2019 Jan 11:1-7. Epub 2019 Jan 11.

b Vasectomy Provider, Nottingham Road Clinic , Mansfield , UK.

The increasingly stringent laboratory-approach to diagnosing azoospermia for post-vasectomy semen analysis (PVSA) continues to be at odds with the simpler approach desired by clinicians. This study describes the analysis of 10 years of PVSA and discusses the outcome in relation to risk, cost and assesses whether more stringent procedures are required. PVSA was performed on 4788 patients initially using a 2-test strategy (16 and 20 weeks post-surgery), moving to 1 test during 2013-2014. Read More

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https://www.tandfonline.com/doi/full/10.1080/14647273.2018.1
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http://dx.doi.org/10.1080/14647273.2018.1562242DOI Listing
January 2019
5 Reads

Altered microRNAs expression levels of sperm and seminal plasma in patients with infertile ejaculates compared with normozoospermic males.

Hum Fertil (Camb) 2019 Jan 11:1-10. Epub 2019 Jan 11.

a Faculty of Medicine, Department of Laboratory Medicine, Division of Clinical Genetics , University of Debrecen , Debrecen , Hungary.

Approximately 15% of couples are unable to conceive after one year of unprotected intercourse. Because sperm can be accessed with ease, it is reasonable to search for non-invasive biomarkers in semen. MicroRNAs are a family of short single-stranded non-coding RNA molecules that are capable of regulating gene expression and causing mRNA degradation. Read More

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http://dx.doi.org/10.1080/14647273.2018.1562241DOI Listing
January 2019
1 Read

Luteal-phase progesterone supplementation in non-IVF treatment: a survey of physicians providing infertility treatment.

Hum Fertil (Camb) 2019 Jan 10:1-7. Epub 2019 Jan 10.

a Department of Obstetrics and Gynecology , University of Oklahoma Health Sciences Center , Oklahoma City , OK , USA.

We sought to examine current use of, and indications for, progesterone supplementation in the luteal phase of non-in vitro fertilization (non-IVF) infertility treatments among Obstetrician Gynaecologists (OB/GYN) compared to Reproductive Endocrinology and Infertility (REI) Subspecialists. Using a web-based survey, the practices of U.S. Read More

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http://dx.doi.org/10.1080/14647273.2018.1562240DOI Listing
January 2019
1 Read

Mutation of GALNTL5 gene identified in patients diagnosed with asthenozoospermia.

Hum Fertil (Camb) 2019 Jan 10:1-8. Epub 2019 Jan 10.

a Research Center for Medical Glycoscience , National Institute of Advanced Industrial Science and Technology (AIST) , Tsukuba , Japan.

Asthenozoospermia is commonly observed in infertile men. However, very few causative gene mutations have been identified because an efficient detection method has not been established. We previously identified a patient with asthenozoospermia carrying a heterozygous point deletion in GALNTL5 by detecting an abnormal reduction in the abundance of GALNTL5 and other marker proteins. Read More

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http://dx.doi.org/10.1080/14647273.2018.1562239DOI Listing
January 2019
17 Reads

Knowledge and decision making about future fertility and oocyte cryopreservation among young women.

Hum Fertil (Camb) 2019 Jan 9:1-10. Epub 2019 Jan 9.

b Duke University Medical Center , Durham , NC , USA.

The objective was to examine what young graduate student women know about preserving fertility/oocyte cryopreservation, and which reproductive resources they use. A prospective, cross-sectional design was used and the study was conducted at a University on the East Coast of the United States. The participants were 278 female graduate students. Read More

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http://dx.doi.org/10.1080/14647273.2018.1546411DOI Listing
January 2019
1 Read

The role of stimulation protocol, number of oocytes retrieved with respect to follicular fluid oxidative stress and IVF outcome.

Hum Fertil (Camb) 2019 Jan 8:1-9. Epub 2019 Jan 8.

a Division of Reproductive and Cytotoxicology , ICMR - National Institute of Occupational Health , Ahmedabad , India.

The study was conducted on a population of 203 women attending the IVF clinic, Ahmedabad, India, to explore the role of stimulation protocol and the number of oocytes retrieved on oxidative stress in follicular fluid and IVF outcome. Follicular fluid was collected during ovum pick-up to determine the oxidative stress markers: superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), total thiols (TT), l-ascorbic acid (AA), total protein, glutathione S-transferase (GST) and glutathione reductase (GRD). The average number of oocytes retrieved was significantly higher in the women receiving a long GnRH agonist protocol compared to GnRH antagonist protocol while the percentage of women with positive IVF outcome was lower in the long agonist protocol. Read More

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http://dx.doi.org/10.1080/14647273.2018.1551630DOI Listing
January 2019
3 Reads
1.018 Impact Factor

High implantation and clinical pregnancy rates with single vitrified-warmed blastocyst transfer and optional aneuploidy testing for all patients.

Hum Fertil (Camb) 2019 Jan 7:1-12. Epub 2019 Jan 7.

a The Bridge Centre , London , UK.

This study reports the results of a 2-year long IVF programme ('One by One') in which all patients (median age 40 years; range 27-45 years) were offered preimplantation genetic testing for aneuploidy (PGT-A) and had all blastocysts vitrified (freeze-only), followed later by single vitrified-warmed blastocyst transfer (vSET) in managed cycles. Between January 2016 and December 2017, a total of 155 patients started 222 treatment cycles and 99 (45%) cycles resulted in one or more vitrified blastocysts (untested or with normal copy number for all chromosomes) available for transfer. Seventeen patients (11%) aged ≤35 years opted out of PGT-A. Read More

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https://www.tandfonline.com/doi/full/10.1080/14647273.2018.1
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http://dx.doi.org/10.1080/14647273.2018.1551628DOI Listing
January 2019
11 Reads

Cross-border and domestic surrogacy in the UK context: an exploration of practical and legal decision-making.

Hum Fertil (Camb) 2018 Dec 11:1-12. Epub 2018 Dec 11.

b NGA Law and Brilliant Beginnings , London , UK.

This study aimed to explore UK intending parent's reasons for cross-border and domestic surrogacy, their preparations for the birth and the practical and legal challenges faced after the birth. An online survey was completed by 203 participants, of which 132 had a child born through surrogacy, 33 were in the process of surrogacy and 38 were planning a surrogacy arrangement. The most common reason for pursuing surrogacy in the UK was wanting a relationship with the surrogate (43%; n = 17) and for conducting surrogacy in the USA was because of a better legal framework (97%; n = 60). Read More

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https://www.tandfonline.com/doi/full/10.1080/14647273.2018.1
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http://dx.doi.org/10.1080/14647273.2018.1540801DOI Listing
December 2018
2 Reads

Tumour necrosis factor alpha gene polymorphisms in women with recurrent pregnancy loss: a meta-analysis.

Hum Fertil (Camb) 2018 Dec 2:1-11. Epub 2018 Dec 2.

a Korea University College of Medicine , Seoul , Korea.

Tumour necrosis factor alpha (TNF-α) concentration is associated with recurrent pregnancy loss (RPL). Moreover, TNF-α promoter polymorphisms affect cellular TNF-α concentrations. Although several studies on TNF-α polymorphisms have been reported, these studies only define specific loci and result in conflicting conclusions. Read More

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https://www.tandfonline.com/doi/full/10.1080/14647273.2018.1
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http://dx.doi.org/10.1080/14647273.2018.1543899DOI Listing
December 2018
14 Reads

Potential effect of inflammation on the failure risk of in vitro fertilization and embryo transfer among infertile women.

Hum Fertil (Camb) 2018 Nov 27:1-9. Epub 2018 Nov 27.

e Reproductive Medical Center , Peking University People's Hospital , Beijing , People's Republic of China.

This study investigated the association between inflammation in infertile women and the risk of IVF-ET failure, as well as the potential effects of various lifestyles on this association. A total of 84 women undergoing IVF-ET in Beijing China were recruited, including 38 women who did not achieve pregnancy after undergoing IVF-ET and 46 women who conceived. Serum samples were collected on the second day of menstruation before the treatment cycle and the inflammatory cytokines (interleukin-1β, interleukin-6, interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1)) were measured. Read More

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https://www.tandfonline.com/doi/full/10.1080/14647273.2018.1
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http://dx.doi.org/10.1080/14647273.2018.1543898DOI Listing
November 2018
12 Reads
1.018 Impact Factor

Assessing the potential of HSPA2 and ADAM2 as two biomarkers for human sperm selection.

Hum Fertil (Camb) 2018 Nov 22:1-11. Epub 2018 Nov 22.

c Monoclonal Antibody Research Center , Avicenna Research Institute (ARI) , ACECR, Tehran , Iran.

Selection of the best sperm, with the least defects, is a critical factor in the success of ART especially in male factor infertility. This study assessed the potential Heat shock protein (HSPA2) and metallopeptidase domain2 (ADAM2) biomarkers for sperm selection. Sperm were obtained from 72 asthenoteratozoospermic and 42 normospermic ejaculates. Read More

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https://www.tandfonline.com/doi/full/10.1080/14647273.2018.1
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http://dx.doi.org/10.1080/14647273.2018.1534277DOI Listing
November 2018
15 Reads

No more donor secrets in the genomic age.

Authors:
Allan A Pacey

Hum Fertil (Camb) 2018 Dec;21(4):223-224

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http://dx.doi.org/10.1080/14647273.2018.1533065DOI Listing
December 2018
1 Read

Levels of total antioxidant capacity and 8-hydroxy-2'-deoxyguanosine of serum and follicular fluid in women undergoing in vitro fertilization: focusing on endometriosis.

Hum Fertil (Camb) 2018 Nov 13:1-9. Epub 2018 Nov 13.

a Department of Obstetrics and Gynecology, Faculty of Medicine , University of Pécs , Pécs , Hungary.

This study was designed to evaluate the levels of oxidative stress (OS) markers, total non-enzymatic antioxidant capacity (TAC) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the serum and follicular fluid (FF) of patients undergoing in vitro fertilization (IVF). The impact of these biomarkers on IVF outcome was also analysed. Samples were obtained from 61 patients (age: 36. Read More

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http://dx.doi.org/10.1080/14647273.2018.1535719DOI Listing
November 2018
18 Reads

Ultrasound monitoring during first-cycle treatment with clomifene citrate: a national survey of compliance with NICE.

Hum Fertil (Camb) 2018 Nov 2:1-7. Epub 2018 Nov 2.

a Faculty of Health Sciences & Wellbeing , University of Sunderland , Sunderland , UK.

The National Institute for Health and Care Excellence Clinical Guideline 156 advises that transvaginal ultrasonography (TVUS) should be used in the first cycle of treatment with clomifene citrate, to assess for multifollicular development and hence the risk of multiple pregnancy. This guidance is based on expert opinion rather than research evidence. We conducted a cross-sectional online and postal survey among UK-based consultant gynaecologists and fertility specialists, to explore compliance with this guideline. Read More

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http://dx.doi.org/10.1080/14647273.2018.1535201DOI Listing
November 2018
2 Reads

The interaction between donor-conceived families and their environment: parents' perceptions of societal understanding and attitudes regarding their family-building.

Hum Fertil (Camb) 2018 Nov 2:1-10. Epub 2018 Nov 2.

a Department of Neurobiology Care Sciences and Society , Karolinska Institutet , Huddinge , Sweden.

Disclosure issues in relation to donor conception have mainly been examined in the context of relationships and interaction within donor-conceived families, whilst influences from outside the family, for example societal ones, have been little researched. This study explored the societal experiences of individuals who build their family with the help of donor conception (i.e. Read More

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http://dx.doi.org/10.1080/14647273.2018.1533256DOI Listing
November 2018
1 Read

Women's experience of social egg freezing: perceptions of success, risks, and 'going it alone'.

Hum Fertil (Camb) 2018 Nov 1:1-7. Epub 2018 Nov 1.

a Centre for Reproduction Research, Faculty of Health and Life Sciences , De Montfort University , Leicester , UK.

Very few studies have explored women's experiences of social egg freezing and the limited primary research on this topic has suggested that users find the process of freezing eggs emotionally challenging. We, therefore, undertook semi-structured interviews with 31 women who identified as undergoing egg freezing for social reasons in order to explore how female users of social egg freezing technology reported their experience of freezing eggs for 'social' reasons. Interviews lasted between 40 minutes and 2 hours, were audio recorded and transcribed verbatim. Read More

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http://dx.doi.org/10.1080/14647273.2018.1522456DOI Listing
November 2018
5 Reads

CYP1A1 gene (6235T

Hum Fertil (Camb) 2018 Oct 22:1-6. Epub 2018 Oct 22.

c Faculty of Medicine, Department of Obstetrics & Gynecology , Suez Canal University , Ismailia , Egypt.

This case-control study was carried out to examine the association between CYP1A1 gene (6235TRead More

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http://dx.doi.org/10.1080/14647273.2018.1522455DOI Listing
October 2018
6 Reads

Variations in the inhibin gene in Kashmiri women with primary ovarian insufficiency.

Hum Fertil (Camb) 2018 Oct 19:1-7. Epub 2018 Oct 19.

a Advanced Centre for Human Genetics , Sher-I-Kashmir Institute of Medical Sciences , Srinagar , India.

Inhibin is a glycoprotein produced by granulosa cells and its main function is the negative feedback control of follicle stimulating hormone (FSH) which has an important role in folliculogenesis. Mutation in the INHα gene leading to decreased bioactive inhibin has been associated with primary ovarian insufficiency (POI). The aim of this study was to investigate the role of variations in the INHα gene in increasing the susceptibility to POI in Kashmiri women. Read More

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http://dx.doi.org/10.1080/14647273.2018.1525502DOI Listing
October 2018
4 Reads

Prevalence of candidate single nucleotide polymorphisms on p53, IL-11, IL-10, VEGF and APOE in patients with repeated implantation failure (RIF) and pregnancy loss (RPL).

Hum Fertil (Camb) 2018 Oct 18:1-6. Epub 2018 Oct 18.

a Molecular Biology, Instituto Bernabeu Biotech , Alicante , Spain.

Recurrent pregnancy loss (RPL; defined as the loss of three or more consecutive pregnancies) and recurrent implantation failure (RIF; when implantation is not achieved after at least three cycles of IVF) are two of the major challenges that reproductive medicine faces. Some polymorphisms have been identified as possible causes of an increased risk of these diseases. This paper studies the prevalence of the polymorphisms in p53, VEGF, IL-10, IL-11 and APOE in RIF and RPL patients that determines the risk for these pathologies. Read More

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https://www.tandfonline.com/doi/full/10.1080/14647273.2018.1
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http://dx.doi.org/10.1080/14647273.2018.1524935DOI Listing
October 2018
2 Reads

The choice for invasive prenatal tests after subfertility.

Hum Fertil (Camb) 2018 Sep 28:1-8. Epub 2018 Sep 28.

a Department of Obstetrics & Gynaecology, GROW School of Oncology and Developmental Biology , Maastricht University Medical Centre , Maastricht , The Netherlands.

The aim of this study was to test whether women who conceived after a period of subfertility are less likely to undergo invasive prenatal testing (IPT) and determine factors of influence in that decision. We conducted a retrospective study at the Maastricht University Medical Centre (MUMC+) to compare the rates of IPT following abnormal results of combined first trimester screening (cFTS) or second trimester screening (STS), or because of advanced maternal age among women tested for the effect of type and duration of subfertility and history of fertility investigations and/or treatment. We included 977 women who underwent IPT between January 2010 and December 2013. Read More

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http://dx.doi.org/10.1080/14647273.2018.1517238DOI Listing
September 2018
1 Read

Failure after fertility treatment: regulation strategies when facing a blocked parenthood goal.

Hum Fertil (Camb) 2018 Sep 26:1-6. Epub 2018 Sep 26.

a School of Psychology , Cardiff University , Cardiff , UK.

Biological parenthood is a central life-goal for many couples that can become blocked when they experience infertility. Many couples who undergo fertility treatment will face failure and consequently have to decide whether to continue with treatment. The present study used the qualitative methodology of Interpretative Phenomenological Analysis to examine self-regulatory approaches that underlie decision-making about continuing treatment. Read More

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http://dx.doi.org/10.1080/14647273.2018.1510186DOI Listing
September 2018
1 Read

Female fertility in the cancer setting: availability and quality of online health information.

Hum Fertil (Camb) 2018 Sep 19:1-9. Epub 2018 Sep 19.

b Department of Obstetrics and Gynecology , Northwestern University , Chicago , IL , USA.

As cancer survival rates continue to increase, so does the relevance of starting or expanding a family after cancer, impacting quality of life. However, the option of fertility preservation is not always addressed by physicians before treatment. In the meanwhile, many patients look for health information online. Read More

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http://dx.doi.org/10.1080/14647273.2018.1506891DOI Listing
September 2018
2 Reads

Association between expression of TNF-α, P53 and HIF1α with asthenozoospermia.

Hum Fertil (Camb) 2018 Sep 17:1-7. Epub 2018 Sep 17.

a Department of Reproductive Biotechnology , Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR , Isfahan , Iran.

Reduced sperm motility (asthenozoospermia) accounts for a significant percentage of male infertility and numerous factors have been suggested to explain this phenomenon among which hypoxic and inflammatory markers are the least studied. Therefore, the aim of this study was to assess the main molecular markers involved in hypoxia (P53 and HIF-1α) and inflammation (TNF-α) pathways in infertile men with asthenozoospermia. Expression of these markers were assessed by qRT-PCR, and analysis of data show that mean of hypoxia markers (P53, HIF-1α) and also TNF- α were significantly higher in infertile men with asthenozoospermia compared to fertile men (p < 0. Read More

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https://www.tandfonline.com/doi/full/10.1080/14647273.2018.1
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http://dx.doi.org/10.1080/14647273.2018.1493750DOI Listing
September 2018
4 Reads

Influence of body mass index on the relationship between endometrial thickness and pregnancy outcome in single blastocyst frozen embryo transfer cycles.

Hum Fertil (Camb) 2018 Sep 17:1-6. Epub 2018 Sep 17.

a Merrion Fertility Clinic , Dublin , Ireland.

To date there is limited published data assessing whether body mass index (BMI) influences endometrial thickness (ET) and whether this impacts on pregnancy outcomes in single blastocyst FET cycles. The objective of this study, therefore, was to examine the relationship between BMI and ET on the outcome of single blastocyst FET cycles over a five-year period from 2012 until 2016. Patient age, BMI, endometrial pattern and ET prior to FET were recorded. Read More

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http://dx.doi.org/10.1080/14647273.2018.1504324DOI Listing
September 2018
2 Reads

Polymorphisms and haplotypes in VDR gene are associated with female idiopathic infertility.

Hum Fertil (Camb) 2018 Sep 17:1-10. Epub 2018 Sep 17.

a Faculty of Medicine , Institute of Forensic Medicine, University of Belgrade , Belgrade , Serbia.

Unexplained infertility refers to the absence of a definable cause of reproductive failure. Vitamin D receptor (VDR) acts as a transcription factor and regulates a number of vitamin D-responsive genes, including those involved in the immune system. Recent finding that VDR is expressed in reproductive tissues suggests a possible importance of vitamin D in pregnancy. Read More

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http://dx.doi.org/10.1080/14647273.2018.1515503DOI Listing
September 2018
11 Reads

Genetic aspects of idiopathic asthenozoospermia as a cause of male infertility.

Hum Fertil (Camb) 2018 Sep 9:1-10. Epub 2018 Sep 9.

a Reproductive Biotechnology Research Centre, Avicenna Research Institute, ACECR , Tehran , Iran.

Infertility is a worldwide problem affecting about 15% of couples trying to conceive. Asthenozoospermia (AZS) is one of the major causes of male infertility, diagnosed by reduced sperm motility, and has no effective therapeutic treatment. To date, a few genes have been found to be associated with AZS in humans and mice, but in most of cases its molecular aetiology remains unknown. Read More

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http://dx.doi.org/10.1080/14647273.2018.1504325DOI Listing
September 2018
1 Read
1.020 Impact Factor

Effects of zinc deficiency on impaired spermatogenesis and male infertility: the role of oxidative stress, inflammation and apoptosis.

Hum Fertil (Camb) 2018 Aug 21:1-12. Epub 2018 Aug 21.

a Chemical Injuries Research Center , Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences , Tehran , Iran.

Zinc (Zn) is necessary for the normal function of the male reproductive system and spermatozoa. Although influences of zinc deficiency on impaired spermatogenesis and male infertility have been widely considered, the molecular and cellular mechanisms of these abnormalities are not well understood. General abnormalities, including hypogonadism, Leydig cells damage, deficiency of sex hormone production and impaired spermatogenesis, as well as inflammation, antioxidant depletion, sperm death and male infertility can be observed during zinc deficiency. Read More

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http://dx.doi.org/10.1080/14647273.2018.1494390DOI Listing
August 2018
2 Reads

A pilot study comparing corifollitropin alfa associated with hp-HMG versus high dose rFSH antagonist protocols for ovarian stimulation in poor responders.

Hum Fertil (Camb) 2018 Aug 21:1-8. Epub 2018 Aug 21.

a Service de biologie et médecine de la reproduction CHU de Nantes , Nantes , France.

Does corifollitropin alfa associated with hp-HMG protocol from the beginning of ovarian stimulation perform better than high dose rFSH alone for ovarian stimulation with GnRH antagonist in poor responders? This retrospective, monocentric, case-control pilot study was conducted in 65 poor responders (Bologna criteria) undergoing 2 consecutive IVF cycles. All patients underwent a first ovarian stimulation cycle with high dose rFSH (≥300 IU/day) alone in antagonist protocol, unfortunately leading to poor ovarian response and no pregnancy. The following cycle was performed with 150 μg of corifollitropin alfa associated with daily injections of hp-HMG from the beginning of the cycle. Read More

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http://dx.doi.org/10.1080/14647273.2018.1504326DOI Listing
August 2018
2 Reads

Fertility facts, figures and future plans: an online survey of university students.

Hum Fertil (Camb) 2018 Jul 30:1-8. Epub 2018 Jul 30.

a Victorian Assisted Reproductive Treatment Authority , Melbourne , Australia.

Most people want and expect to have children but lack of awareness about the biological limits of fertility may reduce their chance of achieving their parenthood goals. We surveyed Australian university students' intentions and expectations for future parenthood, knowledge about fertility and preferred sources of fertility information. Male and female students (n = 1215) completed an anonymous 34-item online questionnaire. Read More

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http://dx.doi.org/10.1080/14647273.2018.1482569DOI Listing
July 2018
1 Read

2017 Impact factor.

Authors:
Allan A Pacey

Hum Fertil (Camb) 2018 Sep;21(3):155

a Academic Unit of Reproductive and Developmental Medicine, Department of Oncology and Metabolism , School of Medicine and Biomedical Sciences, University of Sheffield, The Jessop Wing , Sheffield , S10 2SF , UK.

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http://dx.doi.org/10.1080/14647273.2018.1494085DOI Listing
September 2018
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Fertility-related knowledge and perceptions of fertility education among adolescents and emerging adults: a qualitative study.

Hum Fertil (Camb) 2018 Jul 10:1-9. Epub 2018 Jul 10.

a School of Psychology , Cardiff University , Cardiff, Wales , UK.

Research shows that young people do not know much about their fertility. In the present study, we examined fertility knowledge and perceptions of a fertility educational brochure (i.e. Read More

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http://dx.doi.org/10.1080/14647273.2018.1486514DOI Listing
July 2018
4 Reads

Polycyclic aromatic hydrocarbons exposure and early miscarriage in women undergoing in vitro fertilization-embryo transfer.

Hum Fertil (Camb) 2018 Jun 28:1-6. Epub 2018 Jun 28.

a State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environment and Resources , Guangzhou Institute of Geochemistry, Chinese Academy of Sciences , Guangzhou , China.

Various factors have been reported to be associated with early miscarriages, including microbial infection, chemical toxicity, maternal disorders and genetic abnormalities. In the present study, a prospective cohort study was conducted to investigate whether urinary concentrations of hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) were associated with early pregnancy loss in women undergoing in vitro fertilization-embryo transfer (IVF-ET). Risk of spontaneous pregnancy loss in patients exposed to PAHs was analysed using 40 patients who had experienced early pregnancy loss compared to 40 who had normal live births. Read More

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http://dx.doi.org/10.1080/14647273.2018.1479888DOI Listing
June 2018
6 Reads
1.020 Impact Factor