4,318 results match your criteria Human Brain Mapping[Journal]


Precentral degeneration and cerebellar compensation in amyotrophic lateral sclerosis: A multimodal MRI analysis.

Hum Brain Mapp 2019 Apr 24. Epub 2019 Apr 24.

Department of Radiology, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, People's Republic of China.

Amyotrophic lateral sclerosis (ALS) is a progressive and intractable neurodegenerative disease of human motor system characterized by progressive muscular weakness and atrophy. A considerable body of research has demonstrated significant structural and functional abnormalities of the primary motor cortex in patients with ALS. In contrast, much less attention has been paid to the abnormalities of cerebellum in this disease. Read More

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http://dx.doi.org/10.1002/hbm.24609DOI Listing

Altered dynamics of brain segregation and integration in poststroke aphasia.

Hum Brain Mapp 2019 Apr 23. Epub 2019 Apr 23.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.

Poststroke aphasia (PSA) results from direct effect of focal lesions and dysfunction of distributed language networks. However, how flexible the activity at specific nodes control global dynamics is currently unknown. In this study, we demonstrate that alterations in the regional activity may cause imbalances between segregation and integration in temporo-spatial pattern, and the transient dynamics are disrupted in PSA patients. Read More

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http://dx.doi.org/10.1002/hbm.24605DOI Listing

Toward neuroimaging-based network biomarkers for transient ischemic attack.

Hum Brain Mapp 2019 Apr 19. Epub 2019 Apr 19.

Institute for Brain Research and Rehabilitation, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, South China Normal University, Guangzhou, China.

Stroke is associated with topological disruptions of large-scale functional brain networks. However, whether these disruptions occur in transient ischemic attack (TIA), an important risk factor for stroke, remains largely unknown. Combining multimodal MRI techniques, we systematically examined TIA-related topological alterations of functional brain networks, and tested their reproducibility, structural, and metabolic substrates, associations with clinical risk factors and abilities as diagnostic and prognostic biomarkers. Read More

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http://dx.doi.org/10.1002/hbm.24602DOI Listing

Impact of sampling rate on statistical significance for single subject fMRI connectivity analysis.

Hum Brain Mapp 2019 Apr 19. Epub 2019 Apr 19.

Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, South Korea.

A typical time series in functional magnetic resonance imaging (fMRI) exhibits autocorrelation, that is, the samples of the time series are dependent. In addition, temporal filtering, one of the crucial steps in preprocessing of functional magnetic resonance images, induces its own autocorrelation. While performing connectivity analysis in fMRI, the impact of the autocorrelation is largely ignored. Read More

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http://dx.doi.org/10.1002/hbm.24600DOI Listing

Individual differences in sustained attention are associated with cortical thickness.

Hum Brain Mapp 2019 Apr 13. Epub 2019 Apr 13.

Translational Research Center for TBI and Stress Disorders (TRACTS), VA RR&D TBI National Research Center, VA Boston Healthcare System, Boston, Massachusetts.

Several studies have examined how individual differences in sustained attention relate to functional brain measures (e.g., functional connectivity), but far fewer studies relate sustained attention ability, or cognition in general, to individual differences in cortical structure. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.24594
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http://dx.doi.org/10.1002/hbm.24594DOI Listing
April 2019
1 Read

Abnormal maturation of the resting-state peak alpha frequency in children with autism spectrum disorder.

Hum Brain Mapp 2019 Apr 11. Epub 2019 Apr 11.

Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Age-related changes in resting-state (RS) neural rhythms in typically developing children (TDC) but not children with autism spectrum disorder (ASD) suggest that RS measures may be of clinical use in ASD only for certain ages. The study examined this issue via assessing RS peak alpha frequency (PAF), a measure previous studies, have indicated as abnormal in ASD. RS magnetoencephalographic (MEG) data were obtained from 141 TDC (6. Read More

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http://dx.doi.org/10.1002/hbm.24598DOI Listing

Neural correlates of dynamic changes in working memory performance during one night of sleep deprivation.

Hum Brain Mapp 2019 Apr 10. Epub 2019 Apr 10.

Sleep and Neuroimage Group, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China.

Total sleep deprivation (TSD) is common in modern society leading to deterioration of multiple aspects of cognition. Dynamic interaction effect of circadian rhythmicity and homeostatic sleep pressure on sustained attention have been intensively investigated, while how this effect was represented on performance and cerebral responses to working memory, another important element of many neurobehavioral tasks, was not well elucidated. Thirty-six healthy subjects with intermediate chronotype performed the Sternberg working-memory task (SWMT) while undergoing functional magnetic resonance imaging every 2 hr from 10:00 p. Read More

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http://dx.doi.org/10.1002/hbm.24596DOI Listing
April 2019
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Dissociating semantic and phonological contributions of the left inferior frontal gyrus to language production.

Hum Brain Mapp 2019 Apr 10. Epub 2019 Apr 10.

Lise Meitner Research Group Cognition and Plasticity, Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Leipzig, Germany.

While the involvement of the left inferior frontal gyrus (IFG) in language production is undisputed, the role of specific subregions at different representational levels remains unclear. Some studies suggest a division of anterior and posterior regions for semantic and phonological processing, respectively. Crucially, evidence thus far only comes from correlative neuroimaging studies, but the functional relevance of the involvement of these subregions during a given task remains elusive. Read More

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http://dx.doi.org/10.1002/hbm.24597DOI Listing

Altered static and dynamic functional network connectivity in Alzheimer's disease and subcortical ischemic vascular disease: shared and specific brain connectivity abnormalities.

Hum Brain Mapp 2019 Apr 5. Epub 2019 Apr 5.

The Mind Research Network, Albuquerque, New Mexico.

Subcortical ischemic vascular disease (SIVD) is a major subtype of vascular dementia with features that overlap clinically with Alzheimer's disease (AD), confounding diagnosis. Neuroimaging is a more specific and biologically based approach for detecting brain changes and thus may help to distinguish these diseases. There is still a lack of knowledge regarding the shared and specific functional brain abnormalities, especially functional connectivity changes in relation to AD and SIVD. Read More

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http://dx.doi.org/10.1002/hbm.24591DOI Listing
April 2019
2 Reads

Dynamic interpersonal neural synchronization underlying pain-induced cooperation in females.

Hum Brain Mapp 2019 Apr 4. Epub 2019 Apr 4.

Laboratory of Brain Functional Genomics (MOE&STCSM), Shanghai Changning-ECNU Mental Health Center, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.

Individuals in pain are motivated to be cooperative in social interaction. Yet, there has been little research on how pain dynamically affects cooperation at a neural level. The present study investigated the cooperative behavior under acute physical pain by asking dyads to complete three blocks of button-press cooperative task, while neural activities were recorded simultaneously on each subject by the fNIRS-based hyperscanning. Read More

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http://dx.doi.org/10.1002/hbm.24592DOI Listing

Distinct and opposite profiles of connectivity during self-reference task and rest in youth at clinical high risk for psychosis.

Hum Brain Mapp 2019 Apr 2. Epub 2019 Apr 2.

Department of Psychology, Northwestern University, Evanston, Illinois.

Self-reference is impaired in psychotic disorders such as schizophrenia, associated with disability, and closely related to characteristic patterns of aberrant brain connectivity. However, at present, it is unclear whether self-reference is impacted in pathogenesis of the disorder. Alterations in connectivity during a self-reference task or resting-state in the psychosis risk (i. Read More

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http://dx.doi.org/10.1002/hbm.24595DOI Listing
April 2019
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Instability of brain connectivity during nonrapid eye movement sleep reflects altered properties of information integration.

Hum Brain Mapp 2019 Apr 2. Epub 2019 Apr 2.

Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.

Nonrapid eye movement (NREM) sleep is associated with fading consciousness in humans. Recent neuroimaging studies have demonstrated the spatiotemporal alterations of the brain functional connectivity (FC) in NREM sleep, suggesting the changes of information integration in the sleeping brain. However, the common stationarity assumption in FC does not satisfactorily explain the dynamic process of information integration during sleep. Read More

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http://dx.doi.org/10.1002/hbm.24590DOI Listing
April 2019
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The cingulum and cingulate U-fibers in children and adolescents with autism spectrum disorders.

Hum Brain Mapp 2019 Apr 2. Epub 2019 Apr 2.

Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, California.

The cingulum is the major fiber system connecting the cingulate and surrounding medial cortex and medial temporal lobe internally and with other brain areas. It is important for social and emotional functions related to core symptomatology in autism spectrum disorders (ASDs). While the cingulum has been examined in autism, the extensive system of cingulate U-fibers has not been studied. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.24586
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http://dx.doi.org/10.1002/hbm.24586DOI Listing
April 2019
3 Reads

Introduction: On the Topic of Cluster Failure.

Authors:

Hum Brain Mapp 2019 May;40(7):2015-2016

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http://dx.doi.org/10.1002/hbm.24575DOI Listing

Corrigendum.

Authors:

Hum Brain Mapp 2019 May 12;40(7):2269. Epub 2019 Mar 12.

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http://dx.doi.org/10.1002/hbm.24576DOI Listing

A divergent breakdown of neurocognitive networks in Parkinson's Disease mild cognitive impairment.

Hum Brain Mapp 2019 Apr 1. Epub 2019 Apr 1.

Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, Spain.

Cognitive decline is a major disabling feature in Parkinson's disease (PD). Multimodal imaging studies have shown functional disruption in neurocognitive networks related to cognitive impairment. However, it remains unknown whether these changes are related to gray matter loss, or whether they outline network vulnerability in the early stages of cognitive impairment. Read More

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http://dx.doi.org/10.1002/hbm.24593DOI Listing
April 2019
1 Read

Dysfunctional white-matter networks in medicated and unmedicated benign epilepsy with centrotemporal spikes.

Hum Brain Mapp 2019 Apr 1. Epub 2019 Apr 1.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.

Benign epilepsy with centrotemporal spikes (BECT) is the most common childhood idiopathic focal epilepsy syndrome, which characterized with white-matter abnormalities in the rolandic cortex. Although diffusion tensor imaging research could characterize white-matter structural architecture, it cannot detect neural activity or white-matter functions. Recent studies demonstrated the functional organization of white-matter by using functional magnetic resonance imaging (fMRI), suggesting that it is feasible to investigate white-matter dysfunctions in BECT. Read More

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http://dx.doi.org/10.1002/hbm.24584DOI Listing

Differential regional decline in dopamine receptor availability across adulthood: Linear and nonlinear effects of age.

Hum Brain Mapp 2019 Apr 1. Epub 2019 Apr 1.

Center for Cognitive Neuroscience, Duke University, Durham, North Carolina.

Theories of adult brain development, based on neuropsychological test results and structural neuroimaging, suggest differential rates of age-related change in function across cortical and subcortical sub-regions. However, it remains unclear if these trends also extend to the aging dopamine system. Here we examined cross-sectional adult age differences in estimates of D2-like receptor binding potential across several cortical and subcortical brain regions using PET imaging and the radiotracer [ F]Fallypride in two samples of healthy human adults (combined N = 132). Read More

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http://dx.doi.org/10.1002/hbm.24585DOI Listing

The functional role of beta-oscillations in the supplementary motor area during reaching and grasping after stroke: A question of structural damage to the corticospinal tract.

Hum Brain Mapp 2019 Mar 29. Epub 2019 Mar 29.

Defitech Chair of Clinical Neuroengineering, Brain Mind Institute and Center for Neuroprosthetics, Swiss Federal Institute of Technology (EPFL), Geneva, Switzerland.

Hand motor function is often severely affected in stroke patients. Non-satisfying recovery limits reintegration into normal daily life. Understanding stroke-related network changes and identifying common principles that might underlie recovered motor function is a prerequisite for the development of interventional therapies to support recovery. Read More

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http://dx.doi.org/10.1002/hbm.24582DOI Listing
March 2019
2 Reads
5.969 Impact Factor

White matter and hypoxic hypobaria in humans.

Hum Brain Mapp 2019 Mar 29. Epub 2019 Mar 29.

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland.

Occupational exposure to hypobaria (low atmospheric pressure) is a risk factor for reduced white matter integrity, increased white matter hyperintensive burden, and decline in cognitive function. We tested the hypothesis that a discrete hypobaric exposure will have a transient impact on cerebral physiology. Cerebral blood flow, fractional anisotropy of water diffusion in cerebral white matter, white matter hyperintensity volume, and concentrations of neurochemicals were measured at baseline and 24 hr and 72 hr postexposure in N = 64 healthy aircrew undergoing standard US Air Force altitude chamber training and compared to N = 60 controls not exposed to hypobaria. Read More

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http://dx.doi.org/10.1002/hbm.24587DOI Listing

Egomotion-related visual areas respond to active leg movements.

Hum Brain Mapp 2019 Mar 28. Epub 2019 Mar 28.

Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.

Monkey neurophysiology and human neuroimaging studies have demonstrated that passive viewing of optic flow stimuli activates a cortical network of temporal, parietal, insular, and cingulate visual motion regions. Here, we tested whether the human visual motion areas involved in processing optic flow signals simulating self-motion are also activated by active lower limb movements, and hence are likely involved in guiding human locomotion. To this aim, we used a combined approach of task-evoked activity and resting-state functional connectivity by fMRI. Read More

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http://dx.doi.org/10.1002/hbm.24589DOI Listing

Brain MRI shows white matter sparing in Kennedy's disease and slow-progressing lower motor neuron disease.

Hum Brain Mapp 2019 Mar 28. Epub 2019 Mar 28.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

The extent of central nervous system involvement in Kennedy's disease (KD) relative to other motor neuron disease (MND) phenotypes still needs to be clarified. In this study, we investigated cortical and white matter (WM) MRI alterations in 25 patients with KD, compared with 24 healthy subjects, 25 patients with sporadic amyotrophic lateral sclerosis (ALS), and 35 cases with lower motor neuron-predominant disease (LMND). LMND patients were clinically differentiated into 24 fast and 11 slow progressors. Read More

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http://dx.doi.org/10.1002/hbm.24583DOI Listing
March 2019
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Investigating systematic bias in brain age estimation with application to post-traumatic stress disorders.

Hum Brain Mapp 2019 Mar 28. Epub 2019 Mar 28.

Department of Psychology, Drexel University, Philadelphia, Pennsylvania.

Brain age prediction using machine-learning techniques has recently attracted growing attention, as it has the potential to serve as a biomarker for characterizing the typical brain development and neuropsychiatric disorders. Yet one long-standing problem is that the predicted brain age is overestimated in younger subjects and underestimated in older. There is a plethora of claims as to the bias origins, both methodologically and in data itself. Read More

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http://dx.doi.org/10.1002/hbm.24588DOI Listing
March 2019
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Different roles of frontal versus striatal atrophy in HIV-associated neurocognitive disorders.

Hum Brain Mapp 2019 Mar 28. Epub 2019 Mar 28.

Department of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia.

Gray matter (GM) atrophy is frequently detected in persons living with HIV, even in the era of combination antiretroviral therapy (cART), but the specificity of regions affected remains elusive. For instance, which regions are consistently affected in HIV? In addition, atrophy at which regions is frequently associated with neurocognitive impairment in HIV? Resolving these questions can potentially help to establish the possible neural profiles of HIV-associated neurocognitive disorders (HAND) severity, which currently is solely defined by neurobehavioral assessments. Here, we addressed these questions using a novel meta-analysis technique, the colocalization-likelihood estimation (CLE) technique, to quantitatively synthesize the findings of GM atrophy in HIV+ adults. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.24577
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http://dx.doi.org/10.1002/hbm.24577DOI Listing
March 2019
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Neural mechanisms of vibrotactile categorization.

Hum Brain Mapp 2019 Mar 28. Epub 2019 Mar 28.

Department of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia.

The grouping of sensory stimuli into categories is fundamental to cognition. Previous research in the visual and auditory systems supports a two-stage processing hierarchy that underlies perceptual categorization: (a) a "bottom-up" perceptual stage in sensory cortices where neurons show selectivity for stimulus features and (b) a "top-down" second stage in higher level cortical areas that categorizes the stimulus-selective input from the first stage. In order to test the hypothesis that the two-stage model applies to the somatosensory system, 14 human participants were trained to categorize vibrotactile stimuli presented to their right forearm. Read More

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http://dx.doi.org/10.1002/hbm.24581DOI Listing

The situation or the person? Individual and task-evoked differences in BOLD activity.

Hum Brain Mapp 2019 Mar 28. Epub 2019 Mar 28.

Department of Psychology, University of Miami, Coral Gables, Florida.

Investigations of between-person variability are enjoying a recent resurgence in functional magnetic resonance imaging (fMRI) research. Several recent studies have found persistent between-person differences in blood-oxygenated-level dependent (BOLD) activation patterns and resting-state functional connectivity. Conflicting findings have been reported regarding the extent to which (a) between-person or (b) within-person cognitive state differences explain differences in BOLD activation patterns. Read More

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http://dx.doi.org/10.1002/hbm.24570DOI Listing

Gesturing tool use and tool transport actions modulates inferior parietal functional connectivity with the dorsal and ventral object processing pathways.

Hum Brain Mapp 2019 Mar 21. Epub 2019 Mar 21.

Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network, Elkins Park, Pennsylvania.

Interacting with manipulable objects (tools) requires the integration of diverse computations supported by anatomically remote regions. Previous functional neuroimaging research has demonstrated the left supramarginal (SMG) exhibits functional connectivity to both ventral and dorsal pathways, supporting the integration of ventrally-mediated tool properties and conceptual knowledge with dorsally-computed volumetric and structural representations of tools. This architecture affords us the opportunity to test whether interactions between the left SMG, ventral visual pathway, and dorsal visual pathway are differentially modulated when participants plan and generate tool-directed gestures emphasizing functional manipulation (tool use gesturing) or structure-based grasping (tool transport gesturing). Read More

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http://dx.doi.org/10.1002/hbm.24565DOI Listing
March 2019
2 Reads

Proprioception and motor performance after stroke: An examination of diffusion properties in sensory and motor pathways.

Hum Brain Mapp 2019 Mar 19. Epub 2019 Mar 19.

Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.

Proprioceptive and motor impairments commonly occur after stroke. Relationships between corticospinal tract (CST) fractional anisotropy (FA) and motor recovery have been identified. However, the relationship between sensory tract microstructure and proprioceptive recovery remains unexplored. Read More

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http://dx.doi.org/10.1002/hbm.24574DOI Listing
March 2019
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Comparing MRI metrics to quantify white matter microstructural damage in multiple sclerosis.

Hum Brain Mapp 2019 Mar 19. Epub 2019 Mar 19.

Division of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.

Quantifying white matter damage in vivo is becoming increasingly important for investigating the effects of neuroprotective and repair strategies in multiple sclerosis (MS). While various approaches are available, the relationship between MRI-based metrics of white matter microstructure in the disease, that is, to what extent the metrics provide complementary versus redundant information, remains largely unexplored. We obtained four microstructural metrics from 123 MS patients: fractional anisotropy (FA), radial diffusivity (RD), myelin water fraction (MWF), and magnetisation transfer ratio (MTR). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.24568
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http://dx.doi.org/10.1002/hbm.24568DOI Listing
March 2019
3 Reads

The spatial chronnectome reveals a dynamic interplay between functional segregation and integration.

Hum Brain Mapp 2019 Mar 18. Epub 2019 Mar 18.

The Mind Research Network, Albuquerque, New Mexico.

The brain is highly dynamic, reorganizing its activity at different interacting spatial and temporal scales, including variation within and between brain networks. The chronnectome is a model of the brain in which nodal activity and connectivity patterns change in fundamental and recurring ways over time. Most literature assumes fixed spatial nodes/networks, ignoring the possibility that spatial nodes/networks may vary in time. Read More

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http://dx.doi.org/10.1002/hbm.24580DOI Listing
March 2019
1 Read
5.969 Impact Factor

Attention modulates topology and dynamics of auditory sensory gating.

Hum Brain Mapp 2019 Mar 18. Epub 2019 Mar 18.

Biomagnetic Center, Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany.

This work challenges the widely accepted model of sensory gating as a preattention inhibitory process by investigating whether attention directed at the second tone (S2) within a paired-click paradigm could affect gating at the cortical level. We utilized magnetoencephalography, magnetic resonance imaging and spatio-temporal source localization to compare the cortical dynamics underlying gating responses across two conditions (passive and attention) in 19 healthy subjects. Source localization results reaffirmed the existence of a fast processing pathway between the prefrontal cortex (PFC) and bilateral superior temporal gyri (STG) that underlies the auditory gating process. Read More

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http://dx.doi.org/10.1002/hbm.24573DOI Listing

Reliable local dynamics in the brain across sessions are revealed by whole-brain modeling of resting state activity.

Hum Brain Mapp 2019 Mar 18. Epub 2019 Mar 18.

Center for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain.

Resting state fMRI is a tool for studying the functional organization of the human brain. Ongoing brain activity at "rest" is highly dynamic, but procedures such as correlation or independent component analysis treat functional connectivity (FC) as if, theoretically, it is stationary and therefore the fluctuations observed in FC are thought as noise. Consequently, FC is not usually used as a single-subject level marker and it is limited to group studies. Read More

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http://dx.doi.org/10.1002/hbm.24572DOI Listing

Test-retest reproducibility of white matter parcellation using diffusion MRI tractography fiber clustering.

Hum Brain Mapp 2019 Mar 15. Epub 2019 Mar 15.

Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

There are two popular approaches for automated white matter parcellation using diffusion MRI tractography, including fiber clustering strategies that group white matter fibers according to their geometric trajectories and cortical-parcellation-based strategies that focus on the structural connectivity among different brain regions of interest. While multiple studies have assessed test-retest reproducibility of automated white matter parcellations using cortical-parcellation-based strategies, there are no existing studies of test-retest reproducibility of fiber clustering parcellation. In this work, we perform what we believe is the first study of fiber clustering white matter parcellation test-retest reproducibility. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.24579
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http://dx.doi.org/10.1002/hbm.24579DOI Listing
March 2019
5 Reads

Illusory own body perceptions mapped in the cingulate cortex-An intracranial stimulation study.

Hum Brain Mapp 2019 Mar 13. Epub 2019 Mar 13.

Neurology Department, University Emergency Hospital Bucharest, Bucharest, Romania.

Body awareness is the result of sensory integration in the posterior parietal cortex; however, other brain structures are part of this process. Our goal is to determine how the cingulate cortex is involved in the representation of our body. We retrospectively selected patients with drug-resistant epilepsy, explored by stereo-electroencephalography, that had the cingulate cortex sampled outside the epileptogenic zone. Read More

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http://doi.wiley.com/10.1002/hbm.24563
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http://dx.doi.org/10.1002/hbm.24563DOI Listing
March 2019
3 Reads

Functional and effective reorganization of the aging brain during unimanual and bimanual hand movements.

Hum Brain Mapp 2019 Mar 13. Epub 2019 Mar 13.

School of Physical and Occupational Therapy, McGill University, Montréal, Québec, Canada.

Motor performance decline observed during aging is linked to changes in brain structure and function, however, the precise neural reorganization associated with these changes remains largely unknown. We investigated the neurophysiological correlates of this reorganization by quantifying functional and effective brain network connectivity in elderly individuals (n = 11; mean age = 67.5 years), compared to young adults (n = 12; mean age = 23. Read More

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http://dx.doi.org/10.1002/hbm.24578DOI Listing

Tracking the acquisition of anticipatory postural adjustments during a bimanual load-lifting task: A MEG study.

Hum Brain Mapp 2019 Mar 13. Epub 2019 Mar 13.

Lyon Neuroscience Research Center (CRNL), Brain Dynamics and Cognition team, INSERM UMRS 1028, CNRS UMR 5292, Université de Lyon, Université Claude Bernard Lyon 1, Lyon, France.

During bimanual coordination, that is, manipulating with the dominant hand an object held by the postural hand, anticipatory postural adjustments are required to cancel the perturbations and ensure postural stabilization. Using magnetoencephalography (MEG), we investigated changes mediating the acquisition of anticipatory postural adjustments during a bimanual load-lifting task. Participants lifted a load with their right hand, hence triggering the fall of a second load fixed to their left (postural) forearm. Read More

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http://doi.wiley.com/10.1002/hbm.24571
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http://dx.doi.org/10.1002/hbm.24571DOI Listing
March 2019
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Neurochemical correlates of scene processing in the precuneus/posterior cingulate cortex: A multimodal fMRI and H-MRS study.

Hum Brain Mapp 2019 Mar 13. Epub 2019 Mar 13.

Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Wales, UK.

Precuneus/posterior cingulate cortex (PCu/PCC) are key components of a midline network, activated during rest but also in tasks that involve construction of scene or situation models. Despite growing interest in PCu/PCC functional alterations in disease and disease risk, the underlying neurochemical modulators of PCu/PCC's task-evoked activity are largely unstudied. Here, a multimodal imaging approach was applied to investigate whether interindividual differences in PCu/PCC fMRI activity, elicited during perceptual discrimination of scene stimuli, were correlated with local brain metabolite levels, measured during resting-state H-MRS. Read More

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http://dx.doi.org/10.1002/hbm.24566DOI Listing
March 2019
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Microstructural changes of the dentato-rubro-thalamic tract after transcranial MR guided focused ultrasound ablation of the posteroventral VIM in essential tremor.

Hum Brain Mapp 2019 Mar 13. Epub 2019 Mar 13.

CINAC (Centro Integral de Neurociencias), University Hospital HM Puerta del Sur, CEU-San Pablo University, Madrid, Spain.

Essential tremor is the most common movement disorder in adults. In patients who are not responsive to medical treatment, functional neurosurgery and, more recently, transcranial MR-guided focused ultrasound thalamotomy are considered effective therapeutic approaches. However, the structural brain changes following a thalamotomy that mediates the clinical improvement are still unclear. Read More

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http://dx.doi.org/10.1002/hbm.24569DOI Listing

The effect of mental countermeasures on neuroimaging-based concealed information tests.

Hum Brain Mapp 2019 Mar 12. Epub 2019 Mar 12.

School of Psychology and Cognition Institute, University of Plymouth, Plymouth, UK.

During the last decade and a half, functional magnetic resonance imaging (fMRI) has been used to determine whether it is possible to detect concealed knowledge by examining brain activation patterns, with mixed results. Concealed information tests rely on the logic that a familiar item (probe) elicits a stronger response than unfamiliar, but otherwise comparable items (irrelevants). Previous work has shown that physical countermeasures can artificially modulate neural responses in concealed information tests, decreasing the accuracy of these methods. Read More

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http://dx.doi.org/10.1002/hbm.24567DOI Listing

Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder.

Hum Brain Mapp 2019 Mar 12. Epub 2019 Mar 12.

Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Neurobiological models to explain vulnerability of major depressive disorder (MDD) are scarce and previous functional magnetic resonance imaging studies mostly examined "static" functional connectivity (FC). Knowing that FC constantly evolves over time, it becomes important to assess how FC dynamically differs in remitted-MDD patients vulnerable for new depressive episodes. Using a recently developed method to examine dynamic FC, we characterized re-emerging FC states during rest in 51 antidepressant-free MDD patients at high risk of recurrence (≥2 previous episodes), and 35 healthy controls. Read More

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http://doi.wiley.com/10.1002/hbm.24559
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http://dx.doi.org/10.1002/hbm.24559DOI Listing
March 2019
5 Reads

Prospects for investigating brain oxygenation in acute stroke: Experience with a non-contrast quantitative BOLD based approach.

Hum Brain Mapp 2019 Mar 12. Epub 2019 Mar 12.

Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Metabolic markers of baseline brain oxygenation and tissue perfusion have an important role to play in the early identification of ischaemic tissue in acute stroke. Although well established MRI techniques exist for mapping brain perfusion, quantitative imaging of brain oxygenation is poorly served. Streamlined-qBOLD (sqBOLD) is a recently developed technique for mapping oxygenation that is well suited to the challenge of investigating acute stroke. Read More

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http://dx.doi.org/10.1002/hbm.24564DOI Listing

Resting-state fMRI detects the effects of learning in short term: A visual search training study.

Hum Brain Mapp 2019 Mar 11. Epub 2019 Mar 11.

Neuropsychology and Functional Neuroimaging Group, Department of Basic Psychology, Clinical Psychology and Psychobiology, Universitat Jaume I, Castellón, Spain.

Can resting-state functional connectivity (rs-FC) detect the impact of learning on the brain in the short term? To test this possibility, we have combined task-FC and rs-FC tested before and after a 30-min visual search training. Forty-two healthy adults (20 men) divided into no-contact control and trained groups completed the study. We studied the connectivity between four different regions of the brain involved in visual search: the primary visual area, the right posterior parietal cortex (rPPC), the right dorsolateral prefrontal cortex (rDLPFC), and the dorsal anterior cingulate cortex (dACC). Read More

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http://dx.doi.org/10.1002/hbm.24560DOI Listing

Activation-based association profiles differentiate network roles across cognitive loads.

Hum Brain Mapp 2019 Mar 10. Epub 2019 Mar 10.

Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China.

Working memory (WM) is a complex and pivotal cognitive system underlying the performance of many cognitive behaviors. Although individual differences in WM performance have previously been linked to the blood oxygenation level-dependent (BOLD) response across several large-scale brain networks, the unique and shared contributions of each large-scale brain network to efficient WM processes across different cognitive loads remain elusive. Using a WM paradigm and functional magnetic resonance imaging (fMRI) from the Human Connectome Project, we proposed a framework to assess the association and shared-association strength between imaging biomarkers and behavioral scales. Read More

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http://dx.doi.org/10.1002/hbm.24561DOI Listing

Transcranial direct current stimulation over the sensory-motor regions inhibits gamma synchrony.

Hum Brain Mapp 2019 Mar 10. Epub 2019 Mar 10.

Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique able to induce plasticity phenomena. Although tDCS application has been spreading over a variety of neuroscience domains, the mechanisms by which the stimulation acts are largely unknown. We investigated tDCS effects on cortical gamma synchrony, which is a crucial player in cortical function. Read More

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http://doi.wiley.com/10.1002/hbm.24556
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http://dx.doi.org/10.1002/hbm.24556DOI Listing
March 2019
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A systematic review of MEG-based studies in Parkinson's disease: The motor system and beyond.

Hum Brain Mapp 2019 Mar 7. Epub 2019 Mar 7.

Amsterdam UMC, location VUmc, Department of Neurology, Amsterdam Neuroscience, Amsterdam, the Netherlands.

Parkinson's disease (PD) is accompanied by functional changes throughout the brain, including changes in the electromagnetic activity recorded with magnetoencephalography (MEG). An integrated overview of these changes, its relationship with clinical symptoms, and the influence of treatment is currently missing. Therefore, we systematically reviewed the MEG studies that have examined oscillatory activity and functional connectivity in the PD-affected brain. Read More

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http://dx.doi.org/10.1002/hbm.24562DOI Listing
March 2019
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Motor cortex representation of deep and superficial neck flexor muscles in individuals with and without neck pain.

Hum Brain Mapp 2019 Mar 5. Epub 2019 Mar 5.

Centre of Clinical Excellence Research in Spinal Pain, Injury and Health, School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia.

Sensorimotor control of neck muscles differs between individuals with and without pain. Differences in the primary motor cortex (M1) maps of these muscles may be involved. This study compared M1 representations of deep (DNF) and superficial (SNF) neck flexor muscles between 10 individuals with neck pain (NP) and 10 painfree controls. Read More

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http://dx.doi.org/10.1002/hbm.24558DOI Listing
March 2019
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Recursion in action: An fMRI study on the generation of new hierarchical levels in motor sequences.

Hum Brain Mapp 2019 Mar 5. Epub 2019 Mar 5.

Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany.

Generation of hierarchical structures, such as the embedding of subordinate elements into larger structures, is a core feature of human cognition. Processing of hierarchies is thought to rely on lateral prefrontal cortex (PFC). However, the neural underpinnings supporting active generation of new hierarchical levels remain poorly understood. Read More

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http://dx.doi.org/10.1002/hbm.24549DOI Listing

Resting-state fMRI effective connectivity between the bed nucleus of the stria terminalis and amygdala nuclei.

Hum Brain Mapp 2019 Mar 4. Epub 2019 Mar 4.

Institute of Medical Psychology and Systems Neuroscience, University Hospital Muenster, Muenster, Germany.

The bed nucleus of the stria terminalis (BNST) and the laterobasal nucleus (LB), centromedial nucleus (CM), and superficial nucleus (SF) of the amygdala form an interconnected dynamical system, whose combined activity mediates a variety of behavioral and autonomic responses in reaction to homeostatic challenges. Although previous research provided deeper insight into the structural and functional connections between these nuclei, studies investigating their resting-state functional magnetic resonance imaging (fMRI) connectivity were solely based on undirected connectivity measures. Here, we used high-quality data of 391 subjects from the Human Connectome Project to estimate the effective connectivity (EC) between the BNST, the LB, CM, and SF through spectral dynamic causal modeling, the relation of the EC estimates with age and sex as well as their stability over time. Read More

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http://dx.doi.org/10.1002/hbm.24555DOI Listing

Neuroanatomical correlates of food addiction symptoms and body mass index in the general population.

Hum Brain Mapp 2019 Feb 28. Epub 2019 Feb 28.

Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

The food addiction model suggests neurobiological similarities between substance-related and addictive disorders and obesity. While structural brain differences have been consistently reported in these conditions, little is known about the neuroanatomical correlates of food addiction. We therefore aimed to determine whether symptoms of food addiction related to body mass index (BMI), personality, and brain structure in a large population-based sample. Read More

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http://dx.doi.org/10.1002/hbm.24557DOI Listing
February 2019
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How the insula speaks to the heart: Cardiac responses to insular stimulation in humans.

Hum Brain Mapp 2019 Feb 28. Epub 2019 Feb 28.

NeuroPain Lab, Lyon Neuroscience Research Centre, CRNL - INSERM U 1028/CNRS UMR 5292, University of Lyon, Lyon, France.

Despite numerous studies suggesting the role of insular cortex in the control of autonomic activity, the exact location of cardiac motor regions remains controversial. We provide here a functional mapping of autonomic cardiac responses to intracortical stimulations of the human insula. The cardiac effects of 100 insular electrical stimulations into 47 epileptic patients were divided into tachycardia, bradycardia, and no cardiac response according to the magnitude of RR interval (RRI) reactivity. Read More

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http://doi.wiley.com/10.1002/hbm.24548
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http://dx.doi.org/10.1002/hbm.24548DOI Listing
February 2019
10 Reads