18,339,450 results match your criteria Human & Experimental Toxicology [Journal]

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Hyperglycemia and T Cell infiltration are associated with stromal and epithelial prostatic hyperplasia in the nonobese diabetic mouse.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Department of Surgery, NorthShore University HealthSystem, Evanston, Illinois.

Background: Prostatic inflammation and various proinflammatory systemic comorbidities, such as diabetes and obesity are associated with human benign prostatic hyperplasia (BPH). There is a paucity of in vivo models reflecting specific aspects of BPH pathogenesis. Our aim was to investigate the nonobese diabetic (NOD) mouse as a potential model for subsequent intervention studies. Read More

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http://dx.doi.org/10.1002/pros.23809DOI Listing
April 2019
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[Ocular Syphilis May Lead to Persistent Visual Dysfunction].

Klin Monbl Augenheilkd 2019 Apr 18;236(4):516-522. Epub 2019 Apr 18.

Augenklinik, UniversitätsSpital Zürich, Universität Zürich, Schweiz.

Purpose: The spectrum of intraocular and systemic findings in patients with ocular syphilis is described. Persistent visual dysfunction and structural abnormality, in spite of targeted antibiotic therapy, were identified and analysed.

Methods: Patients with ocular syphilis who were treated at University Hospital Zurich (USZ) between 2010 and 2018 were included in this study. Read More

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http://dx.doi.org/10.1055/a-0854-3421DOI Listing

A Rhesus Monkey With a Naturally Occurring Impairment of Disparity Vergence. II. Abnormal Near Response Cell Activity in the Supraoculomotor Area.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1670-1676

Washington National Primate Research Center, University of Washington, Seattle, Washington, United States.

Purpose: Convergence insufficiency is a very common disorder that can have significant adverse effects on school performance. When reading, children with this disorder often experience diplopia and headaches. We have recently obtained a rhesus monkey with a naturally occurring impairment of vergence eye movements. Read More

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http://dx.doi.org/10.1167/iovs.18-26440DOI Listing

A Rhesus Monkey With a Naturally Occurring Impairment of Disparity Vergence. I. Behavioral Comparisons to Vergence in a Normal Animal.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1657-1669

Washington National Primate Research Center, University of Washington, Seattle, Washington, United States.

Purpose: Human children with disorders affecting vergence eye movements have difficulty during close work, such as reading. Patients with convergence insufficiency show a receded near point and an exophoria that is greater at near than at far. Neurologic abnormalities may underlie these symptoms, but it is difficult to test this idea directly because there is no animal model for this disorder. Read More

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http://dx.doi.org/10.1167/iovs.18-26438DOI Listing

House Dust Mite-Induced Allergic Lung Inflammation Is Not Exacerbated in Sickle Cell Disease Mice.

Int Arch Allergy Immunol 2019 Apr 18:1-9. Epub 2019 Apr 18.

Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, Connecticut, USA,

Aim: Asthma appears to be a common comorbid condition in children with sickle cell disease (SCD), and such individuals may be at a higher risk for increased morbidity and mortality. However, several reports have indicated that asthma severity is not particularly high in those with SCD, and airway hyperreactivity and wheeze may be independently associated with SCD. In SCD mice, exacerbated allergic airway disease (AAD) has been observed in response to the model antigen ovalbumin (OVA). Read More

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https://www.karger.com/Article/FullText/499043
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http://dx.doi.org/10.1159/000499043DOI Listing
April 2019
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Functional Connectivity and Metabolic Alterations in Medial Prefrontal Cortex in a Rat Model of Fetal Alcohol Spectrum Disorder: A Resting-State Functional Magnetic Resonance Imaging and in vivo Proton Magnetic Resonance Spectroscopy Study.

Dev Neurosci 2019 Apr 18:1-12. Epub 2019 Apr 18.

Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA,

Prenatal ethanol exposure alters brain structure, functional connectivity, and behavior in humans and rats. Behavioral changes include deficits in executive function, which requires cooperative activity between the frontal cortices and other brain regions. In this study, we analyzed the functional connectivity and neurochemical levels of the prefrontal cortex (PFC) using resting-state functional magnetic resonance imaging (rsfMRI) and proton magnetic resonance spectroscopy (1H-MRS) in ethanol-exposed (Eth) and control (Ctr) rats. Read More

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http://dx.doi.org/10.1159/000499183DOI Listing

Influence of Gamma-Hydroxybutyric Acid-Use and Gamma-Hydroxybutyric Acid-Induced Coma on Affect and the Affective Network.

Eur Addict Res 2019 Apr 18:1-9. Epub 2019 Apr 18.

Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: Gamma-hydroxybutyric acid (GHB) is a drug of abuse associated with increased emergency room attendances, due to GHB-induced comas. Withdrawal from GHB often increases social anxiety and is linked to alterations in emotion processing. However, little is known about the effects of GHB-use and GHB-induced comas on affect regulation in humans. Read More

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http://dx.doi.org/10.1159/000497381DOI Listing

Cutaneous perfusion of the human lactating breast: a pilot study with laser Doppler perfusion monitoring.

Physiol Meas 2019 Apr 18. Epub 2019 Apr 18.

Biomedical Photonic Imaging, University of Twente, Drienerlolaan 5, building Zuidhorst 256, Enschede, Overijssel, 7500AE, NETHERLANDS.

<i>Objective</i>: Knowledge on the hemodynamics of the human lactating breast contributes to our understanding of lactation physiology, as well as the development and management of breastfeeding problems. The objective of this pilot study was to investigate whether laser Doppler perfusion monitoring (LDPM) can be employed to measure physiological changes in mammary cutaneous perfusion during milk extraction. <i>Approach</i>: We evaluated mammary cutaneous perfusion with LDPM in 9 lactating women during milk extraction in both the ipsilateral ('milk extracting') and contralateral ('passive') breast. Read More

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http://dx.doi.org/10.1088/1361-6579/ab1ad7DOI Listing

Low-dose radiation: interagency collaboration on planning research could improve information on health effects.

J Radiol Prot 2019 Apr 18. Epub 2019 Apr 18.

US Government Accountability Office, Washington, District of Columbia, UNITED STATES.

In September 2017, the U.S. Government Accountability Office (GAO) issued a report on the scientific basis for federal protections against the harmful effects of ionizing radiation-particularly low-dose radiation, or below about 100 millisieverts (10 rem). Read More

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http://iopscience.iop.org/article/10.1088/1361-6498/ab1ada
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http://dx.doi.org/10.1088/1361-6498/ab1adaDOI Listing
April 2019
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Role of Nodal signalling in testis development and initiation of testicular cancer.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

A Jorgensen, Department of Growth and Reproduction, Rigshospitalet, Kobenhavn, Denmark.

Testicular development from the initially bipotential gonad is a tightly regulated process involving a complex signalling cascade to ensure proper sequential expression of signalling factors and secretion of steroid hormones. Initially, Sertoli cell specification facilitates differentiation of the steroidogenic fetal Leydig cells and establishment of the somatic niche, which is critical in supporting the germ cell population. Impairment of the somatic niche during fetal life may lead to development of male reproductive disorders, including arrest of gonocyte differentiation, which is considered the first step in the testicular cancer pathogenesis. Read More

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http://dx.doi.org/10.1530/REP-18-0641DOI Listing

Screening for mutations in selected miRNA genes in hypogonadotropic hypogonadism patients.

Endocr Connect 2019 May;8(5):506-509

Institute of Biomedicine/Physiology, Biomedicum Helsinki and Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland.

In approximately half of congenital hypogonadotropic hypogonadism (cHH) patients, the genetic cause remains unidentified. Since the lack of certain miRNAs in animal models has led to cHH, we sequenced human miRNAs predicted to regulate cHH-related genes (MIR7-3, MIR141, MIR429 and MIR200A-C) in 24 cHH patients with Sanger sequencing. A heterozygous variant in MIR200A (rs202051309; general population frequency of 0. Read More

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http://dx.doi.org/10.1530/EC-19-0080DOI Listing

Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation.

Stem Cell Res 2019 Apr 10;37:101434. Epub 2019 Apr 10.

Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA. Electronic address:

Patient-derived induced pluripotent stem cells (iPSCs) have become a promising resource for exploring genetics of complex diseases, discovering new drugs, and advancing regenerative medicine. Increasingly, laboratories are creating their own banks of iPSCs derived from diverse donors. However, there are not yet standardized guidelines for qualifying these cell lines, i. Read More

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http://dx.doi.org/10.1016/j.scr.2019.101434DOI Listing

Multiple distinct O-Mannosylation pathways in eukaryotes.

Curr Opin Struct Biol 2019 Apr 15;56:171-178. Epub 2019 Apr 15.

Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark. Electronic address:

Protein O-mannosylation (O-Man), originally discovered in yeast five decades ago, is an important post-translational modification (PTM) conserved from bacteria to humans, but not found in plants or nematodes. Until recently, the homologous family of ER-located protein O-mannosyl transferases (PMT1-7 in yeast; POMT1/POMT2 in humans), were the only known enzymes involved in directing O-Man biosynthesis in eukaryotes. However, recent studies demonstrate the existence of multiple distinct O-Man glycosylation pathways indicating that the genetic and biosynthetic regulation of O-Man in eukaryotes is more complex than previously envisioned. Read More

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http://dx.doi.org/10.1016/j.sbi.2019.03.003DOI Listing

Machine learning and big data in psychiatry: toward clinical applications.

Curr Opin Neurobiol 2019 Apr 15;55:152-159. Epub 2019 Apr 15.

Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, England, United Kingdom; Division of Psychiatry, University College London, London, England, United Kingdom; Camden and Islington NHS Foundation Trust, London, England, United Kingdom. Electronic address:

Psychiatry is a medical field concerned with the treatment of mental illness. Psychiatric disorders broadly relate to higher functions of the brain, and as such are richly intertwined with social, cultural, and experiential factors. This makes them exquisitely complex phenomena that depend on and interact with a large number of variables. Read More

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http://dx.doi.org/10.1016/j.conb.2019.02.006DOI Listing

In silico analysis of different signal peptides for the secretory production of recombinant human keratinocyte growth factor in Escherichia coli.

Comput Biol Chem 2019 Mar 29;80:225-233. Epub 2019 Mar 29.

Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Background: The recombinant human truncated Keratinocyte growth factor (Palifermin) is the only FDA approved medicine for the treatment of oral mucositis. The Keratinocyte growth factor is a fairly unstable protein due to its high aggregation propensity and therefore its expression as a secretory protein may results in the production of a protein with more stability, higher solubility, better folding, enhanced biological activity, N-terminal authenticity and simplified downstream processing.

Objective: The aim of this study was in silico evaluation of 31 different secretory signal peptides to determine the best theoretical candidates for the secretory production of recombinant truncated human KGF in E. Read More

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http://dx.doi.org/10.1016/j.compbiolchem.2019.03.003DOI Listing

A method for the cell-cycle-specific analysis of radiation-induced chromosome aberrations and breaks.

Mutat Res 2019 Apr 6;815:10-19. Epub 2019 Apr 6.

Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, Essen, Germany. Electronic address:

The classical G-assay is widely used to assess cell-radiosensitivity and cancer phenotype: Cells are exposed to low doses of ionizing-radiation (IR) and collected for cytogenetic- analysis ˜1.5 h later. In this way, chromosome-damage is measured in cells irradiated in G-phase, without retrieving information regarding kinetics of chromosome-break-repair. Read More

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http://dx.doi.org/10.1016/j.mrfmmm.2019.04.001DOI Listing

Serotonin transporter gene methylation predicts long-term cortisol concentrations in hair.

Psychoneuroendocrinology 2019 Mar 29;106:179-182. Epub 2019 Mar 29.

Chair of Biopsychology, Faculty of Psychology, Technische Universität Dresden, Germany.

Epigenetic signatures, such as DNA methylation (DNA), have been implicated in long-term dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis and related health risks. Based on a wealth of neuroendocrine studies on genetic polymorphisms in the serotonin transporter gene (SLC6A4), this locus constitutes a key candidate to explore associations of DNA patterns and HPA-axis functioning. The few studies addressing this link so far exclusively relied on spot measurements of HPA-axis activity, which may not adequately reflect cortisol output over prolonged periods of time. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.03.033DOI Listing

Belizatinib: Novel reactive intermediates and bioactivation pathways characterized by LC-MS/MS.

J Pharm Biomed Anal 2019 Apr 6;171:132-147. Epub 2019 Apr 6.

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt. Electronic address:

Belizatinib (BZB; TSR-011) is a next-generation anaplastic lymphoma kinase inhibitor that also inhibits tropomyosin-related kinases A/B/C. In this in-vitro study, we examined the formation of reactive metabolites from BZB using rat liver microsomes or human liver microsomes in the presence of a trapping agent (potassium cyanide) to generate iminium reactive intermediates. Identification of the in vitro BZB metabolites indicated that the major in-vitro metabolic reaction involved hydroxylation of the piperidine moiety. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.04.006DOI Listing

G-quadruplex and duplex DNA binding studies of novel Ruthenium(II) complexes containing ascididemin ligands.

J Inorg Biochem 2019 Apr 6;196:110681. Epub 2019 Apr 6.

Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai 200092, PR China. Electronic address:

In this paper, three new Ruthenium(II) polypyridyl complexes containing ascididemin (ASC) as main ligand have been synthesized and characterized. Their interactions with different G-quadruplex (Htelo, c-myc and c-kit) (Htelo: human telomeric DNA, c-myc: cellular-myelocytomatosis viral oncogene, c-kit: oncogene c-kit promoter sequences) and duplex (ds26) DNA sequences were comparatively studied with the free ligand ASC by a series of spectroscopic techniques including UV-vis (ultraviolet-visible) spectroscopy, FID (fluorescent intercalator displacement) assay, and FRET (fluorescence resonance energy transfer) melting assay. Molecular docking studies were also performed to support the binding mode of the compounds with G-quadruplex DNA. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.021DOI Listing

Inactivation of NikR from Helicobacter pylori by a bismuth drug.

J Inorg Biochem 2019 Apr 8;196:110685. Epub 2019 Apr 8.

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou, China, 510275. Electronic address:

The NikR protein is an essential DNA regulator of Helicobacter pylori, a human pathogen, which infects almost half of the world's population. Herein, we comprehensively characterized the interaction of a bismuth drug with Helicobacter pylori NikR. We show that Bi(III) can occupy the high-affinity Ni(II) site of NikR. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.025DOI Listing

Interaction of neurotransmitters and neurochemicals with lymphocytes.

J Neuroimmunol 2019 Apr 11;332:99-111. Epub 2019 Apr 11.

The University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, Brisbane, Australia; Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia. Electronic address:

Neurotransmitters and neurochemicals can act on lymphocytes by binding to receptors expressed by lymphocytes. This review describes lymphocyte expression of receptors for a selection of neurotransmitters and neurochemicals, the anatomical locations where lymphocytes can interact with neurotransmitters, and the effects of the neurotransmitters on lymphocyte function. Implications for health and disease are also discussed. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.04.006DOI Listing

Steady-state visual evoked potentials reveal enhanced neural responses to illusory surfaces during a concurrent visual attention task.

Cortex 2019 Mar 26;117:217-227. Epub 2019 Mar 26.

The University of Queensland, Queensland Brain Institute, St Lucia, QLD, Australia; The University of Queensland, School of Psychology, St Lucia, QLD, Australia; Canadian Institute for Advanced Research (CIFAR), Toronto, Canada.

Under natural viewing conditions, visual stimuli are often obscured by occluding surfaces. To aid object recognition, the visual system actively reconstructs the missing information, as exemplified in the classic Kanizsa illusion, a phenomenon termed "modal completion". Single-cell recordings in monkeys have shown that neurons in early visual cortex respond to illusory contours, but it has proven difficult to measure the neural correlates of modal completion in humans. Read More

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http://dx.doi.org/10.1016/j.cortex.2019.03.014DOI Listing

Exposure effects of endotoxin-free titanium-based wear particles to human osteoblasts.

J Mech Behav Biomed Mater 2019 Apr 10;95:143-152. Epub 2019 Apr 10.

Department of Physics, UNESP, São Paulo State University, 17033-360, Bauru, SP, Brazil.

Titanium-based materials are widely employed by the biomedical industry in orthopedic and dental implants. However, when placed into the human body, these materials are highly susceptible to degradation processes, such as corrosion, wear, and tribocorrosion. As a consequence, metallic ions or particles (debris) may be released, and although several studies have been conducted in recent years to better understand the effects of their exposure to living cells, a consensual opinion has not yet been obtained. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.04.003DOI Listing

Characterization of a Dibenzofuran-degrading strain of Pseudomonas aeruginosa, FA-HZ1.

Environ Pollut 2019 Apr 8;250:262-273. Epub 2019 Apr 8.

State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China. Electronic address:

Dibenzofuran (DBF) derivatives have caused serious environmental problems, especially those produced by paper pulp bleaching and incineration processes. Prominent for its resilient mutagenicity and toxicity, DBF poses a major challenge to human health. In the present study, a new strain of Pseudomonas aeruginosa, FA-HZ1, with high DBF-degrading activity was isolated and identified. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491193032
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http://dx.doi.org/10.1016/j.envpol.2019.04.026DOI Listing
April 2019
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Effects of perfluorooctanoic acid on stem Leydig cell functions in the rat.

Environ Pollut 2019 Apr 9;250:206-215. Epub 2019 Apr 9.

Department of Pediatrics, Peking University First Hospital, No.1 Xi'an Men Street, West District, Beijing, 100034, China; Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. Electronic address:

Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic (PFOS) are two perfluorinated chemical products widely existing in the environment. Evidence suggested that PFOA might relate to male reproductive dysfunction in rats and humans. PFOA exposure inhibited the function of Leydig cells. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.03.120DOI Listing

Chronic exposure to green light aggravates high-fat diet-induced obesity and metabolic disorders in male mice.

Ecotoxicol Environ Saf 2019 Apr 15;178:94-104. Epub 2019 Apr 15.

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, PR China; School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, PR China. Electronic address:

Light is involved in many critical physiological or biochemical processes of human beings, such as visual sensing and the production of vitamin D. Recent studies have showed that the lights of different wavelengths have a profound influence in life activities. For example, blue light promotes alertness, whereas green light (GL) induces sleep in mice. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.013DOI Listing

Male workers' exposure characteristics of ΣPCDD/F from a municipal solid waste incinerator in south China through hair analysis.

Ecotoxicol Environ Saf 2019 Apr 15;178:105-112. Epub 2019 Apr 15.

South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou, 510000, China. Electronic address:

Human hair, flue gas and fly ash from a municipal solid waste incinerator (MSWI) in south China were collected and analyzed for polychlorinated dibenzo-p-dioxin (PCDD) and polychlorinated dibenzofuran (PCDF). The ΣPCDD/F level in hair from male workers were higher than those from residents. The Principal Component Analysis (PCA) suggested that ΣPCDD/F in flue gas is an external source of male workers' hair ΣPCDD/F. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.011DOI Listing

Combined effects of environmental xeno-estrogens within multi-component mixtures: Comparison of in vitro human- and zebrafish-based estrogenicity bioassays.

Chemosphere 2019 Apr 9;227:334-344. Epub 2019 Apr 9.

Institut National de l'Environnement Industriel et des risques (INERIS), Unité Ecotoxicologie in vitro et in vivo, UMR-I 02 SEBIO, 60550, Verneuil-en-Halatte, France. Electronic address:

Some recent studies showed that in vitro bioassays based on fish or human estrogen receptor (ER) activation may have distinct responses to environmental samples, highlighting the need to better understand bioassay-specific ER response to environmental mixtures. For this purpose, we investigated a 12-compound mixture in two mixture ratios (M1 and M2) on zebrafish (zf) liver cells stably expressing zfERα (ZELHα cells) or zfERβ2 (ZELHβ2 cells) and on human ER-reporter gene (MELN) cells. The mixture included the well-known ER ligands bisphenol A (BPA) and genistein (GEN), and other compounds representatives of a freshwater background contamination. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.060DOI Listing

Calu-3 cells are largely resistant to entry driven by filovirus glycoproteins and the entry defect can be rescued by directed expression of DC-SIGN or cathepsin L.

Virology 2019 Apr 3;532:22-29. Epub 2019 Apr 3.

Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany; Faculty of Biology and Psychology, Wilhelm-Weber-Str. 2, University Göttingen, 37073 Göttingen, Germany. Electronic address:

Priming of the viral glycoprotein (GP) by the cellular proteases cathepsin B and L (CatB, CatL) is believed to be essential for cell entry of filoviruses. However, pseudotyping systems that predominantly produce non-filamentous particles have frequently been used to prove this concept. Here, we report that GP-mediated entry of retroviral-, rhabdoviral and filoviral particles depends on CatB/CatL activity and that this effect is cell line-independent. Read More

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http://dx.doi.org/10.1016/j.virol.2019.03.020DOI Listing

Superparamagnetic iron oxide nanoparticles of curcumin enhance gemcitabine therapeutic response in pancreatic cancer.

Biomaterials 2019 Apr 8;208:83-97. Epub 2019 Apr 8.

Department of Pharmaceutical Sciences and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, USA. Electronic address:

Pancreatic cancer is a complex disease accounting for fibrotic tumors and an aggressive phenotype. Gemcitabine (GEM) is used as a standard therapy, which develops chemoresistance leading to poor patient outcome. We have recently developed a superparamagnetic iron oxide nanoparticle (SPION) formulation of curcumin (SP-CUR), which is a nontoxic, bioactive anti-inflammatory/anti-cancer agent for its enhanced delivery in tumors. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.04.005DOI Listing

Environmental impacts of dietary quality improvement in China.

J Environ Manage 2019 Apr 15;240:518-526. Epub 2019 Apr 15.

Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, 100084, China.

Dietary-related risks rank top among all the health risks in many countries. The 2nd United Nations Sustainable Development Goal aims to end hunger, achieve food security and improved nutrition and promote sustainable agriculture. Yet whether improving nutritional quality also benefits the environment is still under-explored, particularly for developing countries. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.03.106DOI Listing

Refining memory assessment of elderly people with cognitive impairment: Insights from the short-term memory binding test.

Arch Gerontol Geriatr 2019 Apr 1;83:114-120. Epub 2019 Apr 1.

Department of Basic Psychology II (Cognitive Processes), Faculty of Psychology, Complutense University of Madrid, Spain.

Alzheimer's disease (AD) affects temporary memory for bound features more remarkably than for individual features. Such selective impairments manifest from presymptomatic through dementia stages via titration procedures. A recent study suggested that without titration and with high memory load the binding selectivity may disappear in people at risk of AD such as those with Mild Cognitive Impairment (MCI). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01674943193008
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http://dx.doi.org/10.1016/j.archger.2019.03.025DOI Listing
April 2019
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In-vitro blood and vascular compatibility of sirolimus-eluting organic/inorganic hybrid stent coatings.

Colloids Surf B Biointerfaces 2019 Apr 9;179:405-413. Epub 2019 Apr 9.

Research Institute of Advanced Manufacturing Technology, Korea Institute of Industrial Technology, Incheon, 21999, Republic of Korea. Electronic address:

The surface characteristics of coronary stents play a pivotal role in inhibiting in-stent restenosis and late-stent thrombosis. In this study, a sol-gel-derived silica xerogel-chitosan hybrid coating was applied to Co-Cr stent and was reported, for the first time, as a biocompatible drug delivery tool in vascular stent application. A dense and uniform chitosan-silica xerogel hybrid coating (<1-μm thick) was applied on bare Co-Cr material. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.04.018DOI Listing

The effect of salts in aqueous media on the formation of the BSA corona on SiO nanoparticles.

Colloids Surf B Biointerfaces 2019 Apr 6;179:374-381. Epub 2019 Apr 6.

Department of Chemical and Biochemical Engineering, 4133 Seamans Center for the Engineering Arts and Sciences, The University of Iowa, Iowa City, IA, USA. Electronic address:

Protein-nanoparticle interactions are garnering attention due to their potential impacts on human health and environmental contamination. The colloidal properties of nanoparticles (NPs) in aqueous media may differ in the presence of natural materials such as salts and proteins. In this study, the interactions between bovine serum albumin (BSA) and fumed hydrophilic silicon dioxide (SiO) NPs were studied in aqueous solutions under variable pH or ion composition. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.04.012DOI Listing

MiR-219a-5p enhances cisplatin sensitivity of human non-small cell lung cancer by targeting FGF9.

Biomed Pharmacother 2019 Apr 15;114:108662. Epub 2019 Apr 15.

Department of Cardiothoracic Surgery, Hwamei Hospital, University of Chinese Academy Of Science , Ningbo, Zhejiang, China.

Cisplatin (DDP) resistance is a major obstacle in the treatment of non-small cell lung cancer (NSCLC). MicroRNA-219a-5p (miR-219a-5p) has been reported to be a tumor suppressor in several cancers, but whether it regulates chemosensitivity in NSCLC remains unclear. Here, using quantitative real time PCR analysis, we observed that miR-219a-5p was down-regulated in responding tumor tissues compared with that in non-responding tumor tissues from NSCLC patients received DDP-based chemotherapy. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108662DOI Listing

UCA1 promotes cell viability, proliferation and migration potential through UCA1/miR-204/CCND2 pathway in primary cystitis glandularis cells.

Biomed Pharmacother 2019 Apr 15;114:108872. Epub 2019 Apr 15.

Reproductive Medicine Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China. Electronic address:

Cystitis glandularis (CG) is an unusual proliferative disorder of the urinary bladder. Increasing evidences demonstrated that long non-coding RNAs (lncRNAs) play important roles in a variety of cellular progresses. However, there are rarely reports about the role and underlying molecular mechanism of lncRNAs in CG. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108872DOI Listing

Molecular characterization of manganese superoxide dismutase (MnSOD) from sterlet Acipenser ruthenus and its responses to Aeromonas hydrophila challenge and hypoxia stress.

Comp Biochem Physiol A Mol Integr Physiol 2019 Apr 15. Epub 2019 Apr 15.

National Freshwater Fisheries Engineering Technology Research Center, Ministry of Science and Technology of China, Beijing Key Laboratory of Fishery Biotechnology (No.BZ0301), Beijing Fisheries Research Institute, Beijing 100068, China. Electronic address:

A novel gene encoding the mitochondrial manganese superoxide dismutase from sterlet Acipenser ruthenus (Ar-MnSOD) was cloned. The full-length cDNA of MnSOD was of 1040 bp with a 672 bp open reading frame encoding 224 amino acids and the deduced amino acid sequence was located in mitochondria. Sequence comparison analysis showed that Ar-MnSOD was highly similar to MnSODs of invertebrates and vertebrates, especially those of freshwater Cyprinidae fishes and mammals. Read More

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http://dx.doi.org/10.1016/j.cbpa.2019.04.010DOI Listing

Evidence for sea spray effect on oxygen stable isotopes in bone phosphate - Approximation and correction using Gaussian Mixture Model clustering.

Sci Total Environ 2019 Apr 10;673:668-684. Epub 2019 Apr 10.

Ludwig Maximilian University Munich, Faculty of Biology, Department of Biology I, Anthropology and Human Genomics, Großhaderner Straße 2, 82152 Planegg-Martinsried, Germany.

Palaeobiodiversity research based on stable isotope analysis in coastal environments can be severely hampered by the so-called "sea spray" effect. This effect shifts the isotopic signal of terrestrial individuals towards too marine values. It is commonly agreed upon that sea spray influences sulphur stable isotopes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193159
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.072DOI Listing
April 2019
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Background levels of dioxin-like polychlorinated biphenyls (dlPCBs), polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs & PXDD/Fs) in sera of pregnant women in Accra, Ghana.

Sci Total Environ 2019 Apr 9;673:631-642. Epub 2019 Apr 9.

Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA. Electronic address:

Human exposure data on dioxins and dioxin-like compounds (DLCs) in Ghana are limited. Based on health risks associated with dioxins and DLCs, the impact of maternal body burdens on foetal exposure is significant. This is the first study that assesses polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs and PXDD/Fs), and dioxin-like polychlorinated biphenyls (dlPCBs) in sera of primiparous Ghanaians. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.060DOI Listing

Patterns of on-task thought in older age are associated with changes in functional connectivity between temporal and prefrontal regions.

Brain Cogn 2019 Apr 15;132:118-128. Epub 2019 Apr 15.

Psychology Department, University of York, York, UK.

Humans spend a large proportion of their time engaged in thoughts unrelated to the task being performed, a tendency that declines with age. However, a clear neuro-cognitive account of what underlies this decrease is lacking. This study addresses the possibility that age-related changes in off-task thinking are correlated with changes in the intrinsic organisation of the brain. Read More

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http://dx.doi.org/10.1016/j.bandc.2019.04.002DOI Listing

Management of caesarean scar pregnancy with high dose intravenous methotrexate infusion therapy: 10-year experience at a single tertiary centre.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 9;237:28-32. Epub 2019 Apr 9.

Women's and Newborn Services, Royal Brisbane and Women's Hospital, Herston, Australia.

Objective: Incidence of caesarean scar pregnancy (CSP) is increasing due to rising caesarean section rate and advanced imaging modalities. At present, there is no consensus to recommend any specific intervention. In our centre, we have adopted the high dose intravenous methotrexate therapy followed by folinic acid for the management of CSP. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.04.008DOI Listing

De novo Domestication: An Alternative Route toward New Crops for the Future.

Mol Plant 2019 Apr 15. Epub 2019 Apr 15.

National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China. Electronic address:

Current global agricultural production must feed over 7 billion people. However, productivity varies greatly across the globe and is under threat from both increased competitions for land and climate change and associated environmental deterioration. Moreover, the increase in human population size and dietary changes are putting an ever-greater burden on agriculture. Read More

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http://dx.doi.org/10.1016/j.molp.2019.03.016DOI Listing

Developing biocompatible silver nanoparticles using epigallocatechin gallate for dental use.

Arch Oral Biol 2019 Mar 28;102:106-112. Epub 2019 Mar 28.

Faculty of Dentistry, The University of Hong Kong, Hong Kong, China. Electronic address:

Objective: To develop silver nanoparticles (AgNPs) using epigallocatechin gallate (EGCG) and evaluate its biocompatibility and inhibition effect on Streptococcus mutans biofilm growth.

Design: AgNPs were synthesized using EGCG as a reducing agent. Cytotoxicity was assessed using half-maximal inhibitory concentration (IC) against human gingival fibroblast (HGF-1) and stem cells from human exfoliated deciduous teeth (SHED). Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.022DOI Listing

The olfactory bulb proteotype differs across frontotemporal dementia spectrum.

J Proteomics 2019 Apr 15. Epub 2019 Apr 15.

Clinical Neuroproteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Irunlarrea, 3, 31008 Pamplona, Spain; Proteored-ISCIII, Proteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Irunlarrea 3, 31008 Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain, Irunlarrea 3, 31008 Pamplona, Spain. Electronic address:

Mild olfactory dysfunction has been observed in frontotemporal dementias (FTD). However, the underlying molecular mechanisms associated to this deficit are poorly understood. We applied quantitative proteomics to analyze pathological effects on the olfactory bulb (OB) from progressive supranuclear palsy (PSP) and frontotemporal lobar degeneration (FTLD-TDP43) subjects respect to elderly non-FTD group. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18743919193011
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http://dx.doi.org/10.1016/j.jprot.2019.04.011DOI Listing
April 2019
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Genetic diversity of zoonotic malaria parasites from mosquito vector and vertebrate hosts.

Infect Genet Evol 2019 Apr 15. Epub 2019 Apr 15.

Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address:

We explored and constructed haplotype network for simian malaria species: Plasmodium knowlesi, P. cynomolgi and P. inui aiming to understand the transmission dynamics between mosquitoes, humans and macaques. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15671348193005
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http://dx.doi.org/10.1016/j.meegid.2019.04.010DOI Listing
April 2019
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A text message delivered smoking cessation intervention: Design and rationale of the Text My Quit Study.

Contemp Clin Trials 2019 Apr 15. Epub 2019 Apr 15.

Live Inspired LLC, Washington, DC, United States.

Introduction: Smoking cessation interventions delivered through mobile technologies offer promise as an effective intervention tool. However, most existing programs have not been empirically tested, were not developed with end-user participation, and/or do not address evidence-based cognitive and behavioral variables shown to enhance smoking cessation in clinical trials. In addition, many programs tested in research trials have required users to access the internet and/or a smartphone app to access all program features, limiting the potential reach of those programs. Read More

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http://dx.doi.org/10.1016/j.cct.2019.04.010DOI Listing

Diagnostic accuracy of hematological parameters in Acute mesenteric ischemic-A systematic Review.

Int J Surg 2019 Apr 15. Epub 2019 Apr 15.

Sir Syed College of Medical Sciences for Girls, Karachi, Pakistan.

Background: We conducted a systematic review on the diagnostic accuracy of classical and newly reported hematological parameters which are easily available in a resource limited setting in making a diagnosis of Acute Mesenteric Ischemia (AMI).

Methods: We searched the PubMed, Scopus, and Cochrane library from January 1940 to April 2018. The search was limited to studies published in English and those involving human subjects only. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.04.005DOI Listing

Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES.

Int J Pharm 2019 Apr 15. Epub 2019 Apr 15.

School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK. Electronic address:

The past fifteen years have witnessed a resurgence of interest in vaginal ring technologies for drug delivery applications, mostly driven by the impetus for development of vaginally-administered antiretroviral microbicides to help reduce the high acquisition rates for human immunodeficiency virus (HIV) among Sub-Saharan African women. Currently, the lead candidate microbicide is a 28-day silicone elastomer vaginal ring releasing dapivirine (Ring-004), an experimental non-nucleoside reverse transcriptase inhibitor. The ring was tested in two pivotal Phase III clinical studies in 2016 and is currently undergoing review by the European Medicines Agency. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.040DOI Listing

Conditioned Pain Modulation Affects the Withdrawal Reflex Pattern to Nociceptive Stimulation in Humans.

Neuroscience 2019 Apr 15. Epub 2019 Apr 15.

Integrative Neuroscience, SMI®, Dept. of Health Science and Technology, Fredrik Bajers Vej 7, Aalborg, Ø, (9220, ), Aalborg, Denmark; Center for Neuroplasticity and Pain (CNAP), SMI®, Dept. of Health Science and Technology, Fredrik Bajers Vej 7, Aalborg, Ø, (9220, ), Aalborg, Denmark. Electronic address:

Human studies have repeatedly shown that conditioning pain modulation (CPM) exerts an overall descending inhibitory effect over spinal nociceptive activity. Previous studies have reported a reduction of the nociceptive withdrawal reflex (NWR) under CPM. Still, how descending control influences the muscle activation patterns involved in this protective behavior remains unknown. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.04.016DOI Listing
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