524,508 results match your criteria Hospitals & health networks / AHA[Journal]


Percutaneous endoscopic gastrostomy in older patients with and without dementia: survival and ethical considerations.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Background And Aim: Notwithstanding multiple recommendations in guidelines, percutaneous endoscopic gastrostomy (PEG)-tube placement is still performed in patients with dementia. In this study we aim to investigate survival in patients with and without dementia after (PEG)-tube placement.

Methods: We conducted a retrospective multicenter study in four different hospitals in The Netherlands. Read More

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December 2018

[Innovative New Evacuation Concept with Emergency Mattresses].

Z Orthop Unfall 2018 Dec 14;156(6):723-724. Epub 2018 Dec 14.

Sicherheitsmanagement, Klinikverbund Südwest GmbH, Sindelfingen.

Indication: In-hospital patients with limited mobility are extremely vulnerable in cases of emergency or fire. In the past, several large fires in multi-story hospitals have resulted in deaths.

Methods: For this reason, we have developed an evacuation mattress that incorporates the functions of an evacuation towel with the comfort of a normal mattress. Read More

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December 2018
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Novel endotypes in heart failure: effects on guideline-directed medical therapy.

Eur Heart J 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiology, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.

Aims: We sought to determine subtypes of patients with heart failure (HF) with a distinct clinical profile and treatment response, using a wide range of biomarkers from various pathophysiological domains.

Methods And Results: We performed unsupervised cluster analysis using 92 established cardiovascular biomarkers to identify mutually exclusive subgroups (endotypes) of 1802 patients with HF and reduced ejection fraction (HFrEF) from the BIOSTAT-CHF project. We validated our findings in an independent cohort of 813 patients. Read More

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December 2018

Hello from the new Editor-in-Chief.

Authors:
Marwan Bukhari

Rheumatology (Oxford) 2019 Jan;58(1):1-2

Rheumatology, University Hospitals of Morecambe Bay NHS Trust, Royal Lancaster Infirmary, Lancaster, UK.

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January 2019

Appropriate use criteria adoption for PCI at an academic medical center.

Eur Heart J 2018 Dec;39(47):4136-4138

Division of Cardiovascular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, 11100 Euclid Ave, Mailstop LKS 5038, Cleveland, Ohio, Phone: (216) 844-7760, Fax: (216) 844-8954.

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December 2018

Effect of education using the virtual social network on the knowledge and attitude of emergency nurses of disaster preparedness: A quasi-experiment study.

Nurse Educ Today 2018 Dec 6;73:88-93. Epub 2018 Dec 6.

School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Nurses play an important role in helping people to cope with disasters. Dealing with disasters requires proper knowledge, attitudes and skills that can be achieved through education. Education through virtual social networks as a method of distance education can be used due to its accessibility and ease of use. Read More

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December 2018

Occurrence of virulence factors in Cronobacter sakazakii and Cronobacter malonaticus originated from clinical samples.

Microb Pathog 2018 Dec 11. Epub 2018 Dec 11.

Microbiology Department, Faculty of Biomedical Sciences, Sabha University, Sabha, Libya.

Background: Cronobacter spp. are Gram-negative, facultative-anaerobic, non-spore forming, enteric coliform bacteria, which belongs to the Enterobacteriaceae family. Cronobacter spp. Read More

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December 2018

De-intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally invasive surgery for resectable HPV-positive oropharyngeal carcinoma.

Cochrane Database Syst Rev 2018 Dec 14;12:CD012939. Epub 2018 Dec 14.

ENT Department, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK, CB2 0QQ.

Background: More than 400,000 cases of oropharyngeal squamous cell cancer (OPSCC) are diagnosed every year worldwide and this is rising. Much of the increase has been attributed to human papillomavirus (HPV). HPV-positive OPSCC patients are often younger and have significantly improved survival relative to HPV-negative patients. Read More

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December 2018

Treatment strategies after acute exacerbations of chronic obstructive pulmonary disease: Impact on mortality.

PLoS One 2018 14;13(12):e0208847. Epub 2018 Dec 14.

Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova de Lleida,IRBLleida, Universitat de Lleida, Lleida, Catalonia, Spain.

Introduction: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common reason for presentation to emergency departments (ED), but the management of these episodes is often heterogeneous regardless of their potential impact on short-term adverse outcomes.

Methods: This was a longitudinal, retrospective study of all patients >40 years old admitted to the ED of two Spanish teaching hospitals for an AECOPD between January 1st and May 31st, 2016. All data were collected from electronic medical records. Read More

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December 2018

Musculoskeletal injuries and absenteeism among healthcare professionals-ICD-10 characterization.

PLoS One 2018 14;13(12):e0207837. Epub 2018 Dec 14.

Department of Occupational Health, Centro Hospitalar Universitário São João, Porto, Portugal.

Introduction: Healthcare workers account for 10% of the EU's total workforce, with a significant proportion of those employed in hospitals. Musculoskeletal injuries are the predominant group of injuries in healthcare professionals due to the physical demands of their work, such as the mobilization and positioning of the dependent patients. The management of this type of problem should take into account direct and indirect costs, such as periods of incapacity for work due to illness, hiring and training of new employees during periods of absence, reduced levels of productivity and the effects on production and quality of work. Read More

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December 2018
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Translating preventive chemotherapy prevalence thresholds for Schistosoma mansoni from the Kato-Katz technique into the point-of-care circulating cathodic antigen diagnostic test.

PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006941. Epub 2018 Dec 14.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Background: Intervention guidelines against Schistosoma mansoni are based on the Kato-Katz technique. However, Kato-Katz thick smears show low sensitivity, especially for light-intensity infections. The point-of-care circulating cathodic antigen (POC-CCA) is a promising rapid diagnostic test detecting antigen output of living worms in urine and results are reported as trace, 1+, 2+, and 3+. Read More

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December 2018
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Impact of a patient-flow physician coordinator on waiting times and length of stay in an emergency department: A before-after cohort study.

PLoS One 2018 14;13(12):e0209035. Epub 2018 Dec 14.

Division of Emergency Medicine, Department of Community, Primary Care and Emergency Medicine, Geneva University Hospitals and School of Medicine, Geneva, Switzerland.

Objective: Overcrowding is common in most emergency departments (ED). Despite the use of validated triage systems, some patients are at risk of delayed medical evaluation. The objective of this study was to assess the impact of a patient-flow physician coordinator (PFPC) on the proportion of patients offered medical evaluation within time limits imposed by the Swiss Emergency Triage Scale (SETS) and on patient flow within the emergency department of a teaching urban hospital. Read More

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December 2018
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Effects of Intimate Partner Violence and Home Environment on Child Language Development in the First 3 Years of Life.

J Dev Behav Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.

Objective: Intimate partner violence (IPV) can adversely affect children's cognitive development, but links between IPV exposure and language development in the earliest years of life remain unknown. The present study examined the effects of IPV and the quality of the home environment on children's language development at age 3 years.

Methods: In a prospective, 5-panel, longitudinal study of 79 mother-child dyads assessed prenatally to age 3 years, we examined standardized measures of receptive and expressive language development at age 3 years. Read More

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December 2018
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Impact of Patient Safety Culture on Missed Nursing Care and Adverse Patient Events.

J Nurs Care Qual 2018 Dec 12. Epub 2018 Dec 12.

Columbia University, School of Nursing, New York, New York (Dr Hessels); Ann May Center for Nursing and Allied Health, Hackensack Meridian Health, Neptune, New Jersey (Drs Hessels, Weaver, and Wurmser); Institute of Evidence-Based Care, Hackensack Meridian Health, Neptune, New Jersey (Ms Paliwal); and Medical Services Division, United Nations, New York, New York (Dr Siddiqui).

Background: A strong patient safety culture (PSC) may be associated with improved patient outcomes in hospitals. The mechanism that explains this relationship is underexplored; missed nursing care may be an important link.

Purpose: The purpose of this study was to describe relationships among PSC, missed nursing care, and 4 types of adverse patient events. Read More

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December 2018

Relationship Between Work Environments, Nurse Outcomes, and Quality of Care in ICUs: Mediating Role of Nursing Care Left Undone.

J Nurs Care Qual 2018 Dec 12. Epub 2018 Dec 12.

School of Nursing, Sun Yat-sen University, Guangzhou, China.

Background: The mechanism of how work environments affect nurse outcomes and quality of care has not been studied in intensive care unit (ICU) settings.

Purpose: The purpose was to investigate the effects of work environment on nurse outcomes and quality of care in ICUs, through the mediating effects of nursing care left undone.

Methods: This study used survey data from 459 nurses from 22 ICUs in 22 hospitals in China. Read More

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December 2018

Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas: Recommendations from the International Society of Gynecological Pathologists.

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S25-S39

Pathology Department, University of California San Francisco, San Francisco, California (J.T.R.) Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada (C.B.G.) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M.) Department of Pathology, University Hospital Arnau de Vilanova and Department of Pathology, University Hospital de Bellvitge, University of Lleida, IRBLLEIDA, IDIBELL, CIBERONC, Spain (X.M.G.) Department of Pathology, New York University Langone Medical Center, New York, New York (K.M.) Department of Pathology, Brigham and Women's Hospital (G.L.M.) Pathology Department, Massachusetts General Hospital (E.O.), Boston, Massachusetts Pathology Department, Yale New Haven Hospital, New Haven, Connecticut (V.P.) Department of Pathology, Johns Hopkins Medical Institutions (B.M.R.) Department of Pathology, University of Maryland School of Medicine (P.S.), Baltimore, Maryland Department of Histopathology, King Edward Memorial Hospital and School for Women's and Infants' Health, University of Western Australia, Perth, Australia (C.J.R.S.) Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK (W.G.M.).

This article provides practical recommendations developed from the International Society of Gynecological Pathologists Endometrial Carcinoma Project to address 4 issues that may arise in the diagnosis of uterine corpus low-grade endometrioid carcinoma: (1) The distinction between atypical hyperplasia and low-grade endometrioid carcinoma. (2) The distinction between low-grade endometrioid carcinoma and serous carcinoma. (3) The distinction between corded and hyalinized or spindle cell variants of low-grade endometrioid carcinoma and carcinosarcoma. Read More

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January 2019

Fit4SurgeryTV at-home prehabilitation for frail elderly planned for colorectal cancer surgery: a pilot study.

Am J Phys Med Rehabil 2018 Dec 13. Epub 2018 Dec 13.

Department of surgery, Academic Medical Center, Amsterdam, The Netherlands.

Objective: The preoperative phase is a potential window of opportunity. Although frail elderly patients are known to be more prone to postoperative complications, they are often not considered capable of accomplishing a full prehabilitation program. The aim of this study was to assess the feasibility of Fit4SurgeryTV, an at-home prehabilitation program specifically designed for frail elderly with colorectal cancer (CRC). Read More

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December 2018

Technique of Fractionated Transcatheter Arterial Embolization for Treating Large Arteriovenous Malformation in Brain Functional Area.

J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing.

Objective: At present, large cranial function area arteriovenous malformation (fAVM) is mainly treated by craniotomy with a high risk of operation and high disability. In recent years, with the continuous improvement of the neural intervention technology, fractionated transcatheter arterial embolization (fTAE) may be used to treat the fAVM instead of surgical treatment. However, its effectiveness for treating fAVM has never been explored. Read More

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December 2018

Regionalization of Retroperitoneal Sarcoma Surgery to High-Volume Hospitals: Missed Opportunities for Outcome Improvement.

J Oncol Pract 2018 Dec 14:JOP1800349. Epub 2018 Dec 14.

MedStar-Georgetown Surgical Outcomes Research Center; MedStar-Georgetown University Hospital; Medstar-Washington Hospital Center; Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC; and MedStar Health Research Institute, Hyattsville, MD.

Purpose:: Surgery continues to be the dominant therapy for the management of retroperitoneal soft-tissue sarcoma (RPS). Many groups advocate performing these resections at high-volume hospitals (HVHs), given their complexity. We therefore sought to explore whether RPS surgery has indeed begun to regionalize to HVHs in the same manner as pancreatic cancer (PC) surgery during the last decade. Read More

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December 2018

Coordination of Care Around Surgery for Colon Cancer: Insights From National Patterns of Physician Encounters With Medicare Beneficiaries.

J Oncol Pract 2018 Dec 14:JOP1800228. Epub 2018 Dec 14.

University of Michigan, Ann Arbor, MI; University of Minnesota, Minneapolis, MN; and University of California San Francisco, San Francisco, CA.

Purpose:: To improve care coordination for complex cancers, it is critical to establish a more nuanced understanding of the types of providers involved. As the number of provider types increases, strategies to support cancer care coordination must adapt to a greater variety of information needs, communication styles, and treatment strategies.

Methods:: We categorized providers into 11 types, using National Provider Identifier specialties. Read More

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December 2018

Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.

Syst Biol Reprod Med 2018 Dec 14:1-16. Epub 2018 Dec 14.

b Division of Pharmacology and Toxicology , CSIR- Indian Institute of Chemical Technology , Hyderabad , India.

We aimed to survey the monogenic causes of disorders of sex development (DSD) and thereby its prevalence in India. This study revealed mutations resulting in androgen insensitivity syndrome, 5α-reductase type 2 deficiency, and gonadal dysgenesis were commonly reported. Intriguingly, AR deficits were the most prevalent (32 mutations) and of 11/26 missense mutations were in exons 4-8 (encoding ligand binding domain). Read More

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December 2018

[The role of agentic capacities in turnover intentions among nurses].

G Ital Med Lav Ergon 2018 Dec;40(4):208-216

Dipartimento di Pedagogia, Psicologia, Filosofia, Università di Cagliari, Italia.

Objectives: Voluntary turnover in the nursing profession is one of the main concerns in hospitals and it requests comprehensive research. This study contributes to explain the reasons related to turnover intention of nurses and provides causes for reflection to improve the working practice.

Methods: 161 nurses and 13 nursing coordinators, working in the wards of two Italian hospitals, participated in the study. Read More

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December 2018

[Features of cognitive function in patients with laryngeal carcinoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1396-1399

Department of Otolaryngology Head and Neck Surgery, the First Hospital, Shanxi Medical University; Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer.

To study the differences in cognitive function between patients with laryngeal carcinoma and healthy volunteers. Patients with laryngeal carcinoma who have been first diagnosed with laryngeal carcinoma, but not received treatment at the Department of Otolaryngology in two hospitals in Shanxi Province and healthy volunteers of the same age, gender-matched and similar education were studied for the purpose to evaluate the cognitive status by using the Wechsler memory scale.No significant difference of age, gender and educational level was found between both groups(>0. Read More

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September 2018

[Psychometric validation of an instrument to evaluate the context of quality improvement and accreditation of hospitals].

Salud Publica Mex 2018 Sep-Oct;60(5):528-538

Instituto Nacional de Salud Pública. México.

Objective: To adapt and validate an instrument to measure the context factors which favor quality improvement initiatives and accreditation of hospitals.

Materials And Methods: The model and questionnaire Model for Understanding Success in Quality (MUSIQ) is adapted and validated for application in Spanish-speaking countries and its specific use in hospital accreditation projects. The theoretical construct of its dimensions is assessed by confirmatory factor analysis (Bartlett test and Kaiser-Meyer-Olkim index) and internal consistency (Cronbach's a), in a study carried out in a sample of 54 hospitals of medium and high complexity in Colombia. Read More

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October 2017

[Laws regulating transplantation should express the contemporaneity. Questions to the constitutionalist Francesco Paolo Casavola and to the philosophers Remo Bodei and Aldo Masullo about the possibility deciding the destiny of one's own organs at the time one decides on how to die and on contacts between donor families and recipients.]

G Ital Nefrol 2018 Dec;35(6)

Dipartimento di Scienze Mediche Traslazionali, Università della Campania Luigi Vanvitelli, Napoli.

Transplantation represents modernity thus the laws regulating the procedure should be continuously renovated and remodeled in order to take full advantage of progress. The debate is about Law no. 219, December 22, 2017 and on Law no. Read More

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December 2018

Preoperative serum albumin as a predictor of complications following total hip replacement in patients with rheumatoid arthritis.

Acta Ortop Mex 2018 Jul-Aug;32(4):193-197

Trauma and Orthopaedic Surgery Hospitals. UMAE «Dr. Victorio de la Fuente Narváez», Mexico City.

Background: Rheumatoid arthritis is a chronic inflammatory disease characterized by polyarthritis with progressive articular wear, immunologic abnormalities and increasing physical limitation. Surgical correction with hip replacement comes as a successful solution for patients with advanced articular destruction. Following intervention, surgical site infection (SSI), venous thromboembolism, sepsis, renal and major cardiovascular complications are among the most cited in the literature. Read More

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December 2018

Anti-vascular Endothelial Growth Factor Treatment of Retinopathy of Prematurity: Efficacy, Safety, and Anatomical Outcomes.

Korean J Ophthalmol 2018 Dec;32(6):451-458

Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: To investigate the efficacy, safety, and anatomical outcomes associated with intravitreal anti-vascular endothelial growth factor (VEGF) treatment of retinopathy of prematurity (ROP).

Methods: We performed a retrospective review of intravitreal anti-VEGF (bevacizumab or ranibizumab) treatment of 153 eyes (83 infants) diagnosed with ROP at two tertiary hospitals from June 2011 to January 2017. The primary outcome was the rate of recurrence requiring additional treatment; secondary outcomes included incidence of major complications and final refractive error. Read More

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December 2018

Prenatal alcohol exposure prevalence as measured by direct ethanol metabolites in meconium in a Native American tribe of the southwest.

Birth Defects Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmaceutical Sciences and Community Environmental Health Program, University of New Mexico College of Pharmacy, Albuquerque, New Mexico.

Background: Although fetal alcohol spectrum disorders represent a significant public health problem, Native Americans are underrepresented in population and targeted screening programs. Prior reports suggest that Native American tribal communities may have a higher prevalence of alcohol use during pregnancy; however, systematic examination using ethanol biomarkers is lacking.

Methods: This study utilized data collected through the Navajo Birth Cohort Study (NBCS)-a birth cohort study of a Southwestern tribal community. Read More

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December 2018
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Effects of Transtheoretical Model-based Intervention on the Self-management of Patients with an Ostomy: a Randomised Controlled Trial.

J Clin Nurs 2018 Dec 14. Epub 2018 Dec 14.

Xiangya Nursing School of Central South University, Changsha, Hunan, China.

Aims And Objectives: To determine the effect of a transtheoretical model (TTM)-based intervention on patients with an ostomy and provide patient-centred, accessible assistance, and dynamic education to improve patient self-management.

Background: Proper self-management may promote the rehabilitation of patients with an ostomy. TTM-based interventions have resulted in positive health behavioural changes. Read More

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December 2018

Contemporary management of primary parapharyngeal space tumors.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Coordinator of the International Head and Neck Scientific Group.

The parapharyngeal space is a complex anatomical area. Primary parapharyngeal tumors are rare tumors and 80% of them are benign. A variety of tumor types can develop in this location; most common are salivary gland neoplasm and neurogenic tumors. Read More

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December 2018

Understanding assessment on a hospital ward for older people: a qualitative study.

J Adv Nurs 2018 Dec 14. Epub 2018 Dec 14.

Warwick Research in Nursing, University of Warwick and Oxford Trauma, Kadoorie Centre, NDORMS, University of Oxford and Oxford University Hospitals NHS Trust.

Aim: To explore assessment on a hospital ward for older people from the perspectives of patients and healthcare professionals.

Design: A qualitative study drawing on grounded theory was undertaken between February 2015 - January 2016.

Methods: Interviews with 15 patients and 22 healthcare professionals, a focus group with six healthcare professionals, 45 hours of observation and review of 18 sets of patient notes. Read More

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December 2018

PROTECT - Trial: A cluster RCT to study the effectiveness of a repositioning aid and tailored repositioning to increase repositioning compliance.

J Adv Nurs 2018 Dec 14. Epub 2018 Dec 14.

Skin Integrity Research Group (SKINT), University Centre for Nursing and Midwifery, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium.

Aim: To study the effectiveness of tailored repositioning and a turning and repositioning system on: (1) nurses' compliance to repositioning frequencies; (2) body posture of patients after repositioning; (3) incidence of pressure ulcers and incontinence-associated dermatitis; (4) nurses' and patients' preferences, comfort and acceptability; and (5) budget impact.

Background: Patient-tailored systematic repositioning is key in pressure ulcer prevention. To date, a clinical decision-making tool is lacking and compliance to pressure ulcer prevention guidelines is low. Read More

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December 2018
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Injecting RNA interference lentiviruses targeting the muscarinic 3 receptor gene into the bladder wall inhibits neurogenic detrusor overactivity in rats with spinal cord injury.

Neurourol Urodyn 2018 Dec 14. Epub 2018 Dec 14.

Department of Urology, Xuanwu Hospital Capital Medical University, Xuanwu District, Beijing, China.

Aims: To investigate the effects of injecting RNA interference (RNAi) lentiviruses targeting the muscarinic 3 (M ) receptor gene into the bladder wall on bladder activity in rats with spinal cord injury (SCI).

Methods: Four M RNAi lentiviruses were constructed and used to infect primary cultured bladder smooth muscle cells (BSMCs). Western blotting and quantitative reverse transcription polymerase chain reaction (qRT-PCR) were performed to determine the optimal RNAi lentivirus with the highest interference efficiency. Read More

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December 2018

Patients' narratives of their patient participation in the myocardial infarction pathway.

J Adv Nurs 2018 Dec 14. Epub 2018 Dec 14.

Clinic of medicine and rehabilitation, Møre og Romsdal Hospital Trust, Ålesund, Norway.

Aim: To explore how patients in areas without local percutaneous coronary intervention facilities experience patient participation in different phases of the myocardial infarction pathway.

Background: Acute treatment of myocardial infarction often involves percutaneous coronary intervention. In Norway, this treatment is centralized at certain hospitals; thus, patients often require long-distance transportation and experience frequent hospital transfers. Read More

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December 2018

The vaginal distention model in mice is not a reliable model of simulated birth trauma-induced stress urinary incontinence.

Neurourol Urodyn 2018 Dec 14. Epub 2018 Dec 14.

Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio.

Aims: Vaginal distention (VD) is a validated model of birth-related trauma in rats. Recently a mouse VD model was reported. Our study was originally conducted to evaluate the impact of age on VD in mice. Read More

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December 2018

Genotype, extrapyramidal features and severity of variant Ataxia-Telangiectasia.

Ann Neurol 2018 Dec 14. Epub 2018 Dec 14.

Ataxia Telangiectasia Service, Respiratory Support and Sleep Centre, Papworth Hospital. Papworth Everard, Cambridge, CB23 3RE, UK.

Objective: Variant Ataxia-Telangiectasia is caused by mutations that allow some retained ATM kinase activity. Here, we describe the clinical features of the largest established cohort of individuals with variant Ataxia-Telangiectasia and explore genotype-phenotype correlations.

Methods: Cross-sectional data were collected retrospectively. Read More

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December 2018
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Electronic patient identification for sample labeling reduces wrong blood in tube errors.

Transfusion 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology and the Institute for Transfusion Medicine, University of Pittsburgh, Pittsburgh, PA.

Background: Wrong blood in tube (WBIT) errors are a preventable cause of ABO-mismatched RBC transfusions. Electronic patient identification systems (e.g. Read More

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December 2018

Respiratory morbidity in young people surviving cancer: Population-based study of hospital admissions, treatment-related risk factors and subsequent mortality.

Int J Cancer 2018 Dec 14. Epub 2018 Dec 14.

Clinical and Population Science Department, School of Medicine, University of Leeds, Leeds, UK.

Respiratory diseases are a major cause of late morbidity and mortality amongst childhood cancer survivors. This population-based study investigates respiratory hospital admissions in long-term survivors of cancers diagnosed in young people to identify specific respiratory morbidities, treatment-related risks and their relationship to subsequent morbidity and mortality. Population-based cancer registrations in Yorkshire, England, diagnosed between 1990 and 2011 aged 0-29 years, were linked to inpatient Hospital Episode Statistics (HES) for admissions up to 2017. Read More

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December 2018

Impact of cancer service centralisation on the radical treatment of men with high-risk and locally advanced prostate cancer: A national cross-sectional analysis in England.

Int J Cancer 2018 Dec 14. Epub 2018 Dec 14.

Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine.

In many countries, specialist cancer services are centralised to improve outcomes. We explored how centralisation affects the radical treatment of high-risk and locally advanced prostate cancer in the English NHS. 79,085 patients diagnosed with high-risk and locally advanced prostate cancer in England (April 2014 to March 2016) were identified in the National Prostate Cancer Audit database. Read More

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December 2018

Comparison of methods for measuring antibiotic consumption in an intensive care unit.

APMIS 2019 Jan;127(1):33-40

Department of Neuroanaesthesiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Hospitals worldwide are working on minimizing unnecessary use of antimicrobials. To assess actual changes of antimicrobial usage, correct and precise measurements are necessary. This study aimed to compare data on the purchase of antibiotics from the pharmacy and the administration of antibiotics to patients, respectively, in an intensive care unit (ICU). Read More

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January 2019

Factors affecting the willingness to join community-based health insurance (CBHI) scheme: A case study survey from Savannakhet Province, Lao P.D.R.

Int J Health Plann Manage 2018 Dec 14. Epub 2018 Dec 14.

College of Public Health Science (CPHS), Chulalongkorn University, Institute building 3 (10th-11th floor), Bangkok, Thailand.

Purpose: Community-based health insurance (CBHI) targets independent worker (self-employed) is currently struggling with inadequate size of risk pooling, low enrollment, and high dropout rate as well as financial sustainability. The objective of this study is to find out the factors that significantly affect the CBHI enrollment incentive. The study applied cross-sectional study design to perform situation analysis, in which the Andersen behavioral model was used as a guideline to identify preliminary characteristics that involved with enrolling incentive. Read More

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December 2018

Does the agglomeration effect occur in the hospital sector? The impact of agglomeration economies on the financial performance of hospitals-An evidence from Poland.

Int J Health Plann Manage 2018 Dec 14. Epub 2018 Dec 14.

Department of Corporate Finance, Faculty of Economics and Sociology, University of Lodz, Lodz, Poland.

The main aim of the article is to analyze the occurrence of agglomeration effect in the hospital sector on the basis of financial performance. The considerations are made on the example of hospitals in Poland-the country that survived the latest economic crisis relatively well, usually generating positive values of GDP, but where still there is an ongoing discussion on the final shape of healthcare financing model. The article is based on the assumption that there occur significant differences in financial performance between hospitals according to their location. Read More

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December 2018

FLiRT Technique "Fistula Lipocytes Regenerative Therapy"; autologous adipose derived mesenchymal stem cells auto-transplantation to treat complex fistula-in-ano - Video Vignette.

Colorectal Dis 2018 Dec 13. Epub 2018 Dec 13.

Department of General Surgery UOC C, University of Rome Tor Vergata, Rome, Italy.

Various surgical options have been proposed for the treatment of Fistula-in-Ano (FIA). A balance between healing, recurrence, and continence preservation rates should be maintained which appears to be difficult in complex FIA, such as recurrent, high trans-sphincteric, anterior fistula in a female, multiple tracts, and patients with Crohn's disease. This article is protected by copyright. Read More

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December 2018

Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia.

Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, Lleida & CIBERONC, Lleida, Spain.

Background: Recent epidemiological studies suggest that past data where superficial spreading melanoma was by far the most common subtype of melanoma may not reflect current patterns of sun exposure or other risk factors more involved in other subtypes of melanoma as lentigo maligna (LM) or lentigo maligna melanoma (LMM).

Methods: In order to measure the current situation in our country, all cases of LM and LMM diagnosed in 23 hospitals in Catalonia, from 2000 to 2007, were recorded.

Results: Although for the global period LM/LMM represented only 8. Read More

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December 2018

Mortality and losses to follow-up among adolescents living with HIV in the IeDEA global cohort collaboration.

J Int AIDS Soc 2018 Dec;21(12):e25215

TREAT Asia/amfAR, The Foundation for AIDS Research, Bangkok, Thailand.

Introduction: We assessed mortality and losses to follow-up (LTFU) during adolescence in routine care settings in the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium.

Methods: Cohorts in the Asia-Pacific, the Caribbean, Central, and South America, and sub-Saharan Africa (Central, East, Southern, West) contributed data, and included adolescents living with HIV (ALHIV) enrolled from January 2003 and aged 10 to 19 years (period of adolescence) while under care up to database closure (June 2016). Follow-up started at age 10 years or the first clinic visit, whichever was later. Read More

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December 2018

Covalent Attachment of Fibronectin onto Emulsion-Templated Porous Polymer Scaffolds Enhances Human Endometrial Stromal Cell Adhesion, Infiltration, and Function.

Macromol Biosci 2018 Dec 13:e1800351. Epub 2018 Dec 13.

S. A. Richardson, Dr. A. M. Eissa, Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.

A novel strategy for the surface functionalization of emulsion-templated highly porous (polyHIPE) materials as well as its application to in vitro 3D cell culture is presented. A heterobifunctional linker that consists of an amine-reactive N-hydroxysuccinimide ester and a photoactivatable nitrophenyl azide, N-sulfosuccinimidyl-6-(4'-azido-2'-nitrophenylamino)hexanoate (sulfo-SANPAH), is utilized to functionalize polyHIPE surfaces. The ability to conjugate a range of compounds (6-aminofluorescein, heptafluorobutylamine, poly(ethylene glycol) bis-amine, and fibronectin) to the polyHIPE surface is demonstrated using fluorescence imaging, FTIR spectroscopy, and X-ray photoelectron spectroscopy. Read More

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December 2018
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"Hard to reach, but not out of reach": Barriers and facilitators to recruiting Black African and Black Caribbean men with prostate cancer and their partners into qualitative research.

Eur J Cancer Care (Engl) 2018 Dec 12:e12977. Epub 2018 Dec 12.

Institute of Nursing and Health Research, Ulster University, Coleraine, UK.

Access and recruitment barriers may have contributed to the underrepresentation of Black African/Caribbean men and their partners in current psychosocial research related to prostate cancer survivors. Whilst some studies have explored recruitment barriers and facilitators from participants' perspectives, little is known from researchers' point of view. This paper aimed to address this gap in the literature. Read More

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December 2018

Kinetics of T-cell subset reconstitution following treatment with bendamustine and rituximab for low-grade lymphoproliferative disease: a population-based analysis.

Br J Haematol 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Haematology, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Delayed lymphocyte and T-cell immune reconstitution following bendamustine-rituximab (BR) for indolent non-Hodgkin lymphoma (iNHL) has been described, but no information is available for chronic lymphocytic leukaemia (CLL). We present a population-based retrospective analysis of immune reconstitution and risk of infection following BR. Outcomes included timing/correlates of CD4+ recovery and risk of ≥grade 3 infections. Read More

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December 2018

Immediate versus delayed removal of urinary catheter after laparoscopic hysterectomy: a randomized-controlled trial.

BJOG 2018 Dec 12. Epub 2018 Dec 12.

Department of Gynaecology, Leids Universitair Medisch Centrum, Leiden, the Netherlands.

Objective: To evaluate if immediate catheter removal (ICR) after laparoscopic hysterectomy is associated with similar retention outcomes compared to delayed removal (DCR).

Study Design: Non-inferiority randomized controlled trial.

Population: Patients undergoing laparoscopic hysterectomy in six hospitals in the Netherlands. Read More

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December 2018

Incidence, Causes, and Correlates of Maternal Near-Miss Morbidity: a multi-centre cross-sectional study.

BJOG 2018 Dec 12. Epub 2018 Dec 12.

University of Michigan, Ann Arbor, Michigan, USA.

Objective: To explore the incidence and factors associated with maternal near-miss.

Design: Cross-sectional study with an embedded case-control study.

Setting: Three tertiary referral hospitals in southern Ghana. Read More

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December 2018
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