530,396 results match your criteria Hospitals & health networks / AHA[Journal]


Letter to the Editor. The career of an academic neurosurgeon: back to the future.

J Neurosurg 2019 Feb 15:1-2. Epub 2019 Feb 15.

3Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.3171/2018.11.JNS183259DOI Listing
February 2019

Reinfection rates following adherence to Infectious Diseases Society of America guideline recommendations in first cerebrospinal fluid shunt infection treatment.

J Neurosurg Pediatr 2019 Feb 15:1-9. Epub 2019 Feb 15.

Departments of1Pediatrics and.

OBJECTIVECSF shunt infection treatment requires both surgical and antibiotic decisions. Using the Hydrocephalus Clinical Research Network (HCRN) Registry and 2004 Infectious Diseases Society of America (IDSA) guidelines that were not proactively distributed to HCRN providers, the authors previously found high adherence to surgical recommendations but poor adherence to intravenous (IV) antibiotic duration recommendations. In general, IV antibiotic duration was longer than recommended. Read More

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http://dx.doi.org/10.3171/2018.11.PEDS18373DOI Listing
February 2019

Comparison of TSNAs concentration in saliva according to type of tobacco smoked.

Environ Res 2018 Dec 6;172:73-80. Epub 2018 Dec 6.

Group of Evaluation of Health Determinants and Health Policies, Department of Basic Sciences, Universitat Internacional de Catalunya, Carrer de Josep Trueta s/n, 08195 Sant Cugat del Vallès, Barcelona, Spain; Tobacco Control Unit, Cancer Prevention and Control Program, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain; Cancer Prevention and Control Group, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address:

Objective: To compare tobacco-specific nitrosamines (TSNAs) measured in saliva according to different types of tobacco smoked in a sample of smokers of the city of Barcelona (Spain).

Methods: We used data from a cross-sectional study of a sample of the adult smoking population of Barcelona, Spain in 2013-2014 (n = 165). We classified smokers in five groups according to the type of tobacco smoked: a) manufactured cigarettes only, b) roll-your-own (RYO) cigarettes only, c) dual smokers (both manufactured and RYO cigarettes), d) manufactured plus other types of tobacco products different from RYO and e) other types of tobacco products different from manufactured and RYO cigarettes. Read More

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http://dx.doi.org/10.1016/j.envres.2018.12.006DOI Listing
December 2018

Mobile obstetric and neonatal simulation based skills training in India.

Midwifery 2019 Feb 7;72:14-22. Epub 2019 Feb 7.

Department of Paediatrics, Monash University, Melbourne, Australia.

Background: The developing world has a significantly high risk of women and babies dying during childbirth. Interprofessional simulation training has improved birth practices and outcomes by impacting clinical and non-technical skills like communication, teamwork, leadership and effective use of resources. While these programs have become a training requirement in many high-income countries, they have not been widely introduced in the low-income, low-resource settings. Read More

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http://dx.doi.org/10.1016/j.midw.2019.02.006DOI Listing
February 2019

'A five-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enterobacteriaceae' - Author's reply.

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Infection Control Program and WHO Collaborating Center, Geneva University Hospitals, Geneva, Switzerland; Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland; Faculty of medicine, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.cmi.2019.02.001DOI Listing
February 2019

The Trend, Feasibility, and Safety of Salpingectomy as a form of Permanent Sterilization.

J Minim Invasive Gynecol 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics & Gynecology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston TX, USA.

Study Objectives: To assess the change in rate of laparoscopic salpingectomy for sterilization after the release of the November 2013 Society of Gynecologic Oncology (SGO) Clinical Practice Statement and the January 2015 American College of Obstetricians and Gynecologists (ACOG) Committee Opinion: Salpingectomy for Ovarian Cancer Prevention. We hypothesized there would be an increase in salpingectomy as a percentage of total laparoscopic sterilizations performed without an increase in complications when compared to conventional bilateral tubal ligation (BTL).

Design: A retrospective cohort study. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.02.003DOI Listing
February 2019

Insight into Imiquimod Skin Permeation and Increased Delivery Using Microneedle Pre-treatment.

Eur J Pharm Biopharm 2019 Feb 13. Epub 2019 Feb 13.

Division of Advanced Materials and Healthcare Technologies, School of Pharmacy, The University of Nottingham, NG7 2RD, UK. Electronic address:

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only licensed by the FDA for superficial BCC. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.02.006DOI Listing
February 2019

Variability in survival and post-cardiac arrest care following successful resuscitation from out-of-hospital cardiac arrest.

Resuscitation 2019 Feb 13. Epub 2019 Feb 13.

Center for Resuscitation Science and Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Aim Of The Study: Regionalization of care for out-of-hospital cardiac arrests (OHCA) may improve patient outcomes. We evaluated inter-hospital variations in post-arrest care provision and the relation between hospital case volume and survival in Pennsylvania.

Methods: This retrospective study (2013-2017) used data from adult OHCA cases in Pennsylvania from the Cardiac Arrest Registry to Enhance Survival. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.02.004DOI Listing
February 2019

Evaluation of the sensitivity of Rρ MRI to pH and macromolecular density.

Magn Reson Imaging 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiology, Box 218, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, United Kingdom, CB2 0QQ. Electronic address:

The tumor microenvironment is characteristically acidic and this extracellular acidosis is known to play a role in carcinogenesis and metastasis and can affect tumor chemosensitivity and radiosensitivity. Intracellular pH has been used as a possible biomarker of salvageable tissue in ischemic stroke. A non-invasive MRI-based approach for the determination and imaging of cerebral pH would be a powerful tool in cancer diagnosis and monitoring, as well as stroke treatment planning. Read More

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http://dx.doi.org/10.1016/j.mri.2019.02.004DOI Listing
February 2019

Experts' Consensus on Intraoperative Radiotherapy for Pancreatic Cancer.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

National Cancer Center, China and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China. Electronic address:

Pancreatic cancer (PC), one of the most lethal malignancies, accounts for 8% to 10% of digestive system cancers, and the incidence is increasing. Surgery, chemotherapy, and radiotherapy have been the main treatment methods but are not very effective. However, only 20% of patients have the opportunity to undergo surgical operation. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.01.038DOI Listing
February 2019

A comparison of apremilast monotherapy and combination therapy for psoriatic arthritis in a real life setting: data from the Leeds Combined Psoriatic Service.

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, UK.

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http://dx.doi.org/10.1016/j.jaad.2019.02.014DOI Listing
February 2019

Hematology reference intervals for transgender adults on stable hormone therapy.

Clin Chim Acta 2019 Feb 13. Epub 2019 Feb 13.

Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, United States.

Background: The complete blood count (CBC) is a cornerstone of patient care. Several of the normal values for the components of the CBC differ by sex and, therefore, male-specific and female-specific reference intervals are required to interpret these laboratory results. Transgender individuals are often prescribed hormone therapy to affirm their gender, with resulting serum hormone concentrations similar to those of cisgender individuals. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.011DOI Listing
February 2019

Habituation and Novelty Detection fNIRS brain responses in 5 and 8 month old infants: The Gambia and UK.

Dev Sci 2019 Feb 16:e12817. Epub 2019 Feb 16.

Department of Medical Physics and Biomedical Engineering, University College London, UK.

The first 1000 days of life are a critical window of vulnerability to exposure to socio-economic and health challenges (i.e. poverty/undernutrition). Read More

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http://dx.doi.org/10.1111/desc.12817DOI Listing
February 2019

Long-term follow-up of a multicentre cohort study on laparoscopic peritoneal lavage for perforated diverticulitis.

Colorectal Dis 2019 Feb 16. Epub 2019 Feb 16.

Department of Surgery, Amsterdam Universitair Medisch Centrum (AMC), Amsterdam, The Netherlands.

Aim: Laparoscopic peritoneal lavage has increasingly been investigated as a promising alternative to sigmoidectomy for perforated diverticulitis with purulent peritonitis. Most studies only reported outcomes up to 12 months. Therefore, the objective of this study was to evaluate long-term outcomes of patients treated with laparoscopic lavage. Read More

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http://dx.doi.org/10.1111/codi.14586DOI Listing
February 2019

Arthroscopic anterior shoulder stabilisation in overhead sport athletes: 5-year follow-up.

Ir J Med Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Trauma & Orthopaedic Surgery, Galway University Hospitals, Galway, Ireland.

Introduction: Shoulder instability following traumatic glenohumeral dislocation is a common injury sustained by athletes particularly in contact and collision sports. Overhead contact sports such as gaelic football and hurling pose a unique hazard to the glenohumeral joint, increasing the risk of dislocation.

Aims: To assess return to sport, level of play, recurrence and functional outcomes in gaelic football and hurling athletes in comparison with players of other sports. Read More

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http://dx.doi.org/10.1007/s11845-019-01986-wDOI Listing
February 2019

The stem cell markers expression CD44v6 and podoplanin in lip cancer: clinical significance.

Virchows Arch 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, Stomatology, Pathology and Radiology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisola, 9-75, Bauru, SP, 17012-901, Brazil.

This study aimed to analyze the immunoexpression of cancer stem cell markers, CD44v6, and podoplanin in 91 patients with lip squamous cell carcinomas (LSCC). The immunostaining of podoplanin and CD44v6 was evaluated in ten high-power fields (× 400 magnification) at the invasive front of LSCC, using a semi-quantitative score method. Chi-square test or Fisher's exact test was used to verify the association of podoplanin and CD44v6 expressions with clinicopathologic variables. Read More

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http://dx.doi.org/10.1007/s00428-019-02539-3DOI Listing
February 2019

Whole tumor ablation of locally recurred hepatocellular carcinoma including retained iodized oil after transarterial chemoembolization improves progression-free survival.

Eur Radiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Objectives: To evaluate and compare clinical outcomes of two different radiofrequency ablation (RFA) methods for locally recurred hepatocellular carcinoma (LrHCC) after locoregional treatment.

Methods: Our institutional review board approved this study with a waiver of informed consent. A total of 313 patients previously treated with transarterial chemoembolization (TACE) (n = 167) and RFA (n = 146) with a single LrHCC ≤ 3 cm was included from five tertiary referral hospitals. Read More

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http://dx.doi.org/10.1007/s00330-018-5993-yDOI Listing
February 2019

Foetal radiation exposure caused by mechanical thrombectomy in large-vessel ischaemic stroke in pregnancy.

Neuroradiology 2019 Feb 15. Epub 2019 Feb 15.

Department of Neuroradiology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK.

Purpose: There is overwhelming evidence for the clinical benefits that are derived following mechanical thrombectomy in large-vessel acute ischaemic stroke. The risk of stroke is elevated in pregnancy due to many factors. To date, there have been two reports, totalling five patients, who have undergone mechanical thrombectomy in pregnancy, thus demonstrating the feasibility of the procedure; however, there is no data on the radiation exposure to the mother or foetus related to this therapy. Read More

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http://dx.doi.org/10.1007/s00234-019-02163-7DOI Listing
February 2019

Health-related quality of life and costs in Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK.

Health-related quality of life (HRQoL) has an increasing role in medical decision-making. This review of the literature aims to provide an overview on HRQoL, costs, and work disability in SS, a disease characterized by focal lymphocytic infiltration of exocrine glands with no therapeutics of proven immunomodulatory potential. HRQoL is markedly reduced in SS in multiple studies across many countries when compared with HRQoL in healthy controls. Read More

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http://dx.doi.org/10.1093/rheumatology/key370DOI Listing
February 2019

Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language.

Nat Commun 2019 Feb 15;10(1):883. Epub 2019 Feb 15.

CHU Sainte-Justine Research Center, Montreal, QC, H3T 1C5, Canada.

The original version of this Article contained an error in the spelling of the author Laurence Faivre, which was incorrectly given as Laurence Faive. This has now been corrected in both the PDF and HTML versions of the Article. Read More

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http://dx.doi.org/10.1038/s41467-019-08800-2DOI Listing
February 2019

The efficacy and toxicity of cabazitaxel for treatment of docetaxel-resistant prostate cancer correlating with the initial doses in Japanese patients.

BMC Cancer 2019 Feb 15;19(1):156. Epub 2019 Feb 15.

Department of Urology, Yamagata University, 2-2-2, Iida-nishi, Yamagata, 990-9585, Japan.

Background: We analyzed the efficacy and toxicity of cabazitaxel (CBZ) at high and low initial doses in Japanese patients with docetaxel-resistant castration-resistant prostate cancer (CRPC).

Methods: We retrospectively evaluated 118 patients who received CBZ for docetaxel-resistant CRPC in 10 university hospitals in Japan between 2014 and 2016. The rate of decrease of prostate-specific antigen (PSA), adverse events, progression-free survival (PFS), and overall survival (OS) were compared between patients receiving initially high (≥22. Read More

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http://dx.doi.org/10.1186/s12885-019-5342-9DOI Listing
February 2019

Nationwide epidemiology of carbapenem resistant Klebsiella pneumoniae isolates from Greek hospitals, with regards to plazomicin and aminoglycoside resistance.

BMC Infect Dis 2019 Feb 15;19(1):167. Epub 2019 Feb 15.

Infectious Diseases Laboratory, 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Faculty of Medicine, Athens, Greece.

Background: To evaluate the in vitro activities of plazomicin and comparator aminoglycosides and elucidate the underlying aminoglycoside resistance mechanisms among carbapenemase-producing K. pneumoniae isolates collected during a nationwide surveillance study in Greek hospitals.

Methods: Three hundred single-patient carbapenemase-producing K. Read More

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http://dx.doi.org/10.1186/s12879-019-3801-1DOI Listing
February 2019

The feasibility of assessing frailty and sarcopenia in hospitalised older people: a comparison of commonly used tools.

BMC Geriatr 2019 Feb 15;19(1):42. Epub 2019 Feb 15.

Academic Geriatric Medicine, University of Southampton, Southampton, UK.

Background: Frailty and sarcopenia are common amongst hospitalised older people and associated with poor healthcare outcomes. Widely recognised tools for their identification are the Fried Frailty Phenotype, its self-report version the FRAIL Scale, and the European Working Group on Sarcopenia in Older People (EWGSOP) criteria. We studied the feasibility of using these tools in a hospital setting of acute wards for older people. Read More

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http://dx.doi.org/10.1186/s12877-019-1053-yDOI Listing
February 2019

Development and validation of the European QUALity (EQUAL) score for mucormycosis management in haematology.

J Antimicrob Chemother 2019 Feb 15. Epub 2019 Feb 15.

Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne, Cologne, Germany.

Background: Mucormycosis is a life-threatening infection in immunocompromised patients and in haematological malignancy patients in particular.

Objectives: Our aim was to develop and evaluate a scoring tool to measure adherence to current guidelines for mucormycosis.

Methods: Current guidelines of scientific societies on mucormycosis management were reviewed. Read More

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http://dx.doi.org/10.1093/jac/dkz051DOI Listing
February 2019

Unifying classification for transdiaphragmatic intercostal hernia and other costal margin injuries†.

Eur J Cardiothorac Surg 2019 Feb 15. Epub 2019 Feb 15.

Department of Cardiothoracic Surgery, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, South Yorkshire, UK.

Objectives: Taxonomy of injuries involving the costal margin is poorly described and surgical management varies. These injuries, though commonly caused by trauma, may also occur spontaneously, in association with coughing or sneezing, and can be severe. Our goal was to describe our experience using sequential segmental analysis of computed tomographic (CT) scans to perform accurate assessment of injuries around the costal margin. Read More

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http://dx.doi.org/10.1093/ejcts/ezz020DOI Listing
February 2019

[Exploration of Medical Equipment Management Development in Public Hospitals].

Zhongguo Yi Liao Qi Xie Za Zhi 2019 Jan;43(1):65-68

Shanghai University of Medicine & Health Sciences, Shanghai, 201318.

With the continuous improvement of the hospital diagnosis and treatment level and the continuous renewal of medical equipment in China, the mismatch between medical equipment management personnel training and the introduction of medical equipment, the development of medical technology and the requirements of modern hospital management is increasingly prominent. This article is based on a current situation survey of medical equipment and management personnel at all levels of hospitals in Shanghai. It discusses joint with professional colleges and universities, and gives suggestions about needs, objectives and practice of personnel training. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2019.01.017DOI Listing
January 2019

[Consideration of Application of Insulin Pen Needles and Supervision].

Authors:
Na Zhan

Zhongguo Yi Liao Qi Xie Za Zhi 2019 Jan;43(1):63-64

Center for Medical Device Evaluation, CFDA, Beijing, 100081.

With the increasing incidence of diabetes mellitus in China, hypodermic injection of artificial insulin to control blood sugar has been popularized. Insulin pen needles are widely used in hospitals, communities and families. This article attempts to explore and think about the harm and countermeasures brought about by the reuse of insulin pen needles from the perspective of medical device supervision. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2019.01.016DOI Listing
January 2019

Healthier Rhythm, Healthier Brain? Integrity of Circadian Melatonin and Temperature Rhythms Relates to the Clinical State of Brain-Injured Patients.

Eur J Neurol 2019 Feb 15. Epub 2019 Feb 15.

University of Salzburg, Department of Psychology, Centre for Cognitive Neuroscience, Hellbrunner Strasse 34, A-5020, Salzburg.

Introduction: Healthy circadian rhythmicity has been suggested to relate to a better state of brain-injured patients and to support the emergence of consciousness in patient groups characterised by a relative instability thereof such as patients with disorders of consciousness (DOC).

Methods: Going beyond earlier studies, we have adopted a systems-level perspective and, using multilevel modelling, assessed the joint predictive value of three indexes of circadian rhythm integrity derived from skin temperature variations, melatoninsulfate (aMT6s) secretion, and physical activity (wrist actigraphy) patterns for DOC patients' (13 unresponsive wakefulness syndrome [UWS]; 7 minimally conscious (exit) state [E/MCS]) behaviourally assessed state (Coma Recovery Scale-Revised [CRS-R] score). Additionally, we have assessed in a subset 16 patients whether patients' behavioural repertoire (CRS-R score) varies with (i) time of day or (ii) offset from the body temperature maximum (BTmax), that is when cognitive performance is expected to peak. Read More

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http://dx.doi.org/10.1111/ene.13935DOI Listing
February 2019

Optimization and Repeatability of Multipool Chemical Exchange Saturation Transfer MRI of the Prostate at 3.0 T.

J Magn Reson Imaging 2019 Feb 15. Epub 2019 Feb 15.

Centre for Medical Imaging, University College London, London, UK.

Background: Chemical exchange saturation transfer (CEST) can potentially support cancer imaging with metabolically derived information. Multiparametric prostate MRI has improved diagnosis but may benefit from additional information to reduce the need for biopsies.

Purpose: To optimize an acquisition and postprocessing protocol for 3. Read More

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http://dx.doi.org/10.1002/jmri.26690DOI Listing
February 2019

Advancing stiffness measurement in rheumatic disease: report from the Stiffness Special Interest group at OMERACT 2018.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From Johns Hopkins University School of Medicine, Baltimore, MD USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK; McGill University, Montreal, Quebec, Canada; Department of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, USA; Division of Medicine, The University of Adelaide, Adelaide, Australia Rheumatology Unit, The Queen Elizabeth Hospital, Woodville, Australia; Horizon Pharma, Inc, Lake Forest, Illinois, USA and Adjunct Professor, College of Pharmacy, University of Illinois, Chicago, IL, USA; Healthy Motivation, Bone and Joint Decade Global Alliance for Musculoskeletal Health, Santa Barbara, California, USA; Janssen Scientific Affairs, LLC, Horsham, PA, USA; Singapore General Hospital, Duke-NUS Medical School; University of Bristol, Bristol, UK; University of West England - Bristol, Bristol, UK. AMO is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health (NIH) under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. Work from the US Cohort was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health (NIH) under award numbers [P30-AR070254 Core B] and [P30-AR053503 Core D] and Patient Centered Outcomes Research Institute (PCORI) Pilot Project Award number [IP2-PI000737], and the Camille Julia Morgan Arthritis Research and Education Fund. All statements in this report including its conclusions are the opinions of the authors and do not necessarily reflect those of PCORI, its board of governors, or its methodology committee, or of NIH or NIAMS. RH is an employee of Horizon Pharma, LLC; CK is an employee of Janssen Scientific Affairs, LLC. Address correspondence to Ethan T Craig, 3900 Woodland Ave., Philadelphia, PA 19104. Email:

Objective: To improve measurement of stiffness in rheumatic disease.

Methods: Data presented included: 1) Two qualitative projects; 2) The RA Stiffness patient-reported outcome measure (RAST); 3) three items assessing stiffness severity, duration, and interference. 3) RESULTS: Stiffness is multidimensional and includes aspects of stiffness experience such as duration, severity, and impact. Read More

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http://dx.doi.org/10.3899/jrheum.181074DOI Listing
February 2019

Preliminary Definitions for Sacroiliac Joint Pathologies in the OMERACT Juvenile Idiopathic Arthritis MRI Score (OMERACT JAMRIS-SIJ).

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

Institute of Medical Sciences, Faculty of Medicine, University of Toronto. Medical Sciences Building, 1 Kings College Circle, Room 2374, Toronto, Ontario, Canada M5S 1A8. Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Avenue, Toronto ON, Canada M5G 1X8. Department of Translational Medicine, SickKids Research Institute, Peter Gilgan Center for Research and Learning, 686 Bay Street, Toronto Ontario, Canada M5G 0A4. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.Department of Rheumatology, University of Alberta, 562 Heritage Medical Research Building, Edmonton, AB, Canada, T6G 2S2. Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. University of Pennsylvania Perelman School of Medicine, Division of Rheumatology, Children's Hospital of Philadelphia and Departments of Pediatric and Epidemiology, Philadelphia, PA, USA. Department of Radiology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland. Department of Radiology and Medical Imaging, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium. Department of Radiology and Diagnostic Imaging, University of Alberta. 2A2.41 WC Mackenzie Health Sciences Center, 8440-112 Street, Edmonton, Alberta, Canada, T6G2B7. Department of Radiology, Nemours Children's Hospital and Health System, Orlando Florida USA. Division of Pediatric Rheumatology, Department of Pediatrics, University of Alberta, Edmonton, AB Canada. Department of Radiology; Hospital Sant Joan de Deu, Adress: Passeige de Sant Joan deDeu, ES 08950 Esplugues de Llobregat, Barcelona, Spain. Department of Radiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, ON Canada M5T 3M7. Reade | Emma Children's Hospital / Academic Medical Center, Amsterdam, The Netherlands. Pediatric Rheumatology Research Institute, PRI Achtern Dieck 9, Bad Bramstedt, DE 2476. Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India-632004. Division of Rheumatology, The Hospital for Sick Children, University of Toronto. Toronto, ON, Canada 555 University Avenue, Toronto ON, Canada M5G 1X8. State University of Campina-UNICAMP, Department of Internal Medicine, Cidade Universitaria, Campina, Sao Paulo Brazil Department of Medical Imaging, University of Toronto. 263 McCaul Street 4th Floor, Toronto, ON, Canada M5T1W7. Department of Rheumatology, Center for Prognosis Studies in Rheumatologic Diseases, Toronto Western Hospital, Toronto Canada. Research Ethics Board approval was granted by the Sickkids Research Ethics Board, REB Number 1000059077. Address correspondence to Andrea S. Doria.

Objective: To develop definitions for the assessment of MRI pathologies of the sacroiliac joints (SIJ) in juvenile idiopathic arthritis (JIA).

Methods: An OMERACT consensus-driven methodology consisting of iterative surveys and focus group meetings within an international group of rheumatologists and radiologists.

Results: Two domains, inflammation and structural, were identified. Read More

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http://dx.doi.org/10.3899/jrheum.181115DOI Listing
February 2019

Characterization and treatment of congenital thrombotic thrombocytopenic purpura.

Blood 2019 Feb 15. Epub 2019 Feb 15.

Department of Haematology, University College London Hospital, London, United Kingdom.

Congenital Thrombotic Thrombocytopenic Purpura (cTTP) is an ultra rare thrombomicroangiopathy caused by an inherited deficiency of ADAMTS13. There is limited data on the genotype-phenotype correlation and no consensus on treatment. We reviewed the largest cohort of cTTP cases, diagnosed in the UK, over the past 15 years. Read More

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http://dx.doi.org/10.1182/blood-2018-11-884700DOI Listing
February 2019

Progression of mycosis fungoides occurs through divergence of tumor immunophenotype by differential expression of HLA-DR.

Blood Adv 2019 Feb;3(4):519-530

Instititute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom; and.

Immunotherapy is a valuable treatment for many cancer patients, and there is considerable interest in understanding the mechanisms of immune evasion to guide appropriate management. Mycosis fungoides (MF) is a malignant disorder of skin-homing CD4 T cells, and it exhibits a highly variable clinical course during which the tumor-specific immune response may be an important determinant. An unusual feature of MF is that tumor-infiltrating lymphocytes (TILs) must attempt to control a malignant cell from within their own lineage. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018025114DOI Listing
February 2019

Neuropsychiatric symptoms in Tanzanian HIV-infected children receiving long-term efavirenz treatment: a multicentre, cross-sectional, observational study.

Lancet HIV 2019 Feb 12. Epub 2019 Feb 12.

Department of Paediatrics, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.

Background: Efavirenz is commonly prescribed for children with HIV infection, yet little is known about risks of neuropsychiatric side-effects. We aimed to compare competence (social involvement, activities, and school performance) and psychopathology (internalising and externalising problems), cognitive performance (intelligence and working memory), and adherence in Tanzanian children on an efavirenz-based versus a non-efavirenz-based regimen.

Methods: In this multicentre, cross-sectional, observational study, we included consecutive children (aged 6-12 years) with HIV infection, on combination antiretroviral therapy (cART) for at least 6 months, and with viral loads of less than 1000 copies per mL from HIV care clinics of three primary health facilities and three referral hospitals in Moshi, Kilimanjaro, Tanzania. Read More

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http://dx.doi.org/10.1016/S2352-3018(18)30329-1DOI Listing
February 2019

Treatment of severe glenoid deficiencies in reverse shoulder arthroplasty: the Glenius Glenoid Reconstruction System experience.

J Shoulder Elbow Surg 2019 Feb 13. Epub 2019 Feb 13.

Traumatology, University Hospitals Leuven, Department of Development and Regeneration, K Katholieke Universiteit (K.U.), Leuven, Belgium.

Background: The treatment of glenoid bone deficiencies in primary or revision total shoulder arthroplasty is challenging. This retrospective study evaluated the short-term clinical and radiologic results of a new custom-made patient-specific glenoid implant.

Methods: We treated 10 patients with severe glenoid deficiencies with the Glenius Glenoid Reconstruction System (Materialise NV, Leuven, Belgium). Read More

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http://dx.doi.org/10.1016/j.jse.2018.11.061DOI Listing
February 2019

Safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of the novel enzyme replacement therapy avalglucosidase alfa (neoGAA) in treatment-naïve and alglucosidase alfa-treated patients with late-onset Pompe disease: A phase 1, open-label, multicenter, multinational, ascending dose study.

Neuromuscul Disord 2018 Dec 17. Epub 2018 Dec 17.

Erasmus Medical Center, Pompe Center, Rotterdam, The Netherlands.

This multicenter/multinational, open-label, ascending-dose study (NCT01898364) evaluated safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of repeat-dose avalglucosidase alfa (neoGAA), a second-generation, recombinant acid α-glucosidase replacement therapy, in late-onset Pompe disease (LOPD). Patients ≥18 years, alglucosidase alfa naïve (Naïve) or previously receiving alglucosidase alfa for ≥9 months (Switch), with baseline FVC ≥50% predicted and independently ambulatory, received every-other-week avalglucosidase alfa 5, 10, or 20 mg/kg over 24 weeks. 9/10 Naïve and 12/14 Switch patients completed the study. Read More

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http://dx.doi.org/10.1016/j.nmd.2018.12.004DOI Listing
December 2018

Stereotactic ablative radiotherapy versus standard radiotherapy in stage 1 non-small-cell lung cancer (TROG 09.02 CHISEL): a phase 3, open-label, randomised controlled trial.

Lancet Oncol 2019 Feb 12. Epub 2019 Feb 12.

Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.

Background: Stereotactic ablative body radiotherapy (SABR) is widely used to treat inoperable stage 1 non-small-cell lung cancer (NSCLC), despite the absence of prospective evidence that this type of treatment improves local control or prolongs overall survival compared with standard radiotherapy. We aimed to compare the two treatment techniques.

Methods: We did this multicentre, phase 3, randomised, controlled trial in 11 hospitals in Australia and three hospitals in New Zealand. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30896-9DOI Listing
February 2019

Prognostic factors in patients with active non-variceal upper gastrointestinal bleeding.

Arab J Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. Electronic address:

Background And Study Aims: Acute upper gastrointestinal bleeding is one of the main causes of hospitalisation. The purpose of this study was to determine the prognostic factors in non-variceal upper gastrointestinal bleeding.

Patients And Methods: Clinical outcomes, demographic and laboratory variables of the subjects were collected from the HIS software and national code with the SQL format from three hospitals in Qazvin. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.01.001DOI Listing
February 2019

Epidemiology study of pediatric primary intussusception aged ≤24 months in pre-rotavirus vaccine era of Jinan, China.

Vaccine 2019 Feb 12. Epub 2019 Feb 12.

Jinan Administrative Committee of International Center for Medical Sciences, Xiyuan building, Huaiyin District, Jinan, Shandong Province, China.

Introduction: Few studies have reported on the epidemiological characteristics of pediatric primary intussusception in the pre-rotavirus vaccine era of China. It is important to complementary baseline data before rotavirus vaccine introduction in China. This study conduct a retrospective investigation and evaluated the incidence rate, described the epidemiology of pediatric primary intussusception aged ≤24 months. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.060DOI Listing
February 2019

Hospital Variation in Child Protection Reports of Substance Exposed Infants.

J Pediatr 2019 Feb 12. Epub 2019 Feb 12.

Department of Pediatrics, University of Washington School of Public Health, Seattle, WA; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA; Harborview Injury Prevention & Research Center, University of Washington, Seattle, WA.

Objective: To examine whether hospital-level factors contribute to discrepancies in reporting to Child Protective Services (CPS) of infants diagnosed with prenatal substance exposure.

Study Design: We used a linked dataset of birth, hospital, and CPS records using diagnostic codes (International Classification of Diseases, Ninth Revision) to identify infants diagnosed with prenatal substance exposure. Using multilevel models, we examined hospital-level and individual birth-level factors in relation to a report to CPS among those infants prenatally exposed to substances. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.065DOI Listing
February 2019

Syncope in the German Nationwide inpatient sample - Syncope in atrial fibrillation/flutter is related to pulmonary embolism and is accompanied by higher in-hospital mortality.

Eur J Intern Med 2019 Feb 13. Epub 2019 Feb 13.

Department of Cardiology, Cardiology I, University Medical Center Mainz (Johannes Gutenberg-University Mainz), Mainz, Germany.

Aims: Syncope is a common phenomenon in the general population. Although most of the causes are of benign origin, some comorbidities are accompanied by high mortality. We aimed to compare the in-hospital mortality of patients with syncope related to different comorbities and investigate the impact of syncope in patients with atrial fibrillation/flutter (AF). Read More

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http://dx.doi.org/10.1016/j.ejim.2019.02.005DOI Listing
February 2019

[Nutritional composition of vending foods of public university and hospital buildings in Asturias].

Aten Primaria 2019 Feb 12. Epub 2019 Feb 12.

Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo, Campus del Cristo, Oviedo, España.

Objective: To evaluate the nutritional composition of food vending machines (VM) located in university public buildings and hospitals in Asturias.

Design: Descriptive cross-sectional study.

Location: The analysis was made of the contents of VMs located in public buildings, hospitals, and university teaching centres in the Principality of Asturias. Read More

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http://dx.doi.org/10.1016/j.aprim.2018.04.010DOI Listing
February 2019

Systematic review of the role of corticosteroids in cervicofacial infections.

Br J Oral Maxillofac Surg 2019 Feb 12. Epub 2019 Feb 12.

Maxillofacial surgery Trainees Research Collaborative, Queen Elizabeth University Hospital, Glasgow.

The role of corticosteroids in the management of cervicofacial infections continues to cause controversy. Systemic anti-inflammatory and immunomodulatory effects that reduce swelling and improve symptoms in the head and neck may make these agents an effective addition to the antibiotics used and to surgical management, although this same effect may dull the physiological response to infection, and allow infections to progress. We have systematically reviewed the evidence for the use of corticosteroids in common cervicofacial infections following the PRISMA guidelines. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.01.010DOI Listing
February 2019

Re: Radiology-led lung cancer escalation pathway: a stream lined innovative service.

Authors:
J Cox J Spratt

Clin Radiol 2019 Feb 12. Epub 2019 Feb 12.

City Hospitals Sunderland NHS Foundation Trust, Sunderland, Tyne and Wear, UK.

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http://dx.doi.org/10.1016/j.crad.2018.11.015DOI Listing
February 2019

Epidemiology of Penile Fractures in United States Emergency Departments: Access to Care Disparities May Lead to Suboptimal Outcomes.

J Sex Med 2019 Feb;16(2):248-256

Boston Medical Center, Boston, MA, USA. Electronic address:

Introduction: The epidemiology of penile fractures in the emergency setting is not well described.

Aim: Examine the incidence, evaluation, management, risk factors predicting surgical repair or hospital transfer, and use of financial resources in patients presenting with penile fractures to the emergency departments (ED) nationwide in the Unites States.

Methods: ED visits with a primary diagnosis of penile fractures (International Classification of Diseases, Ninth Edition codes) between 2010-2014 were abstracted from the Nationwide Emergency Department Sample. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.12.009DOI Listing
February 2019

The Woman's Body (Not the Man's One) Is Used to Evaluate Sexual Desire: An Eye-Tracking Study of Automatic Visual Attention.

J Sex Med 2019 Feb;16(2):195-202

Quality of Care Unit, University Hospitals of Geneva, Geneva, Switzerland; Department of General Internal Medicine, Rehabilitation and Geriatrics, University of Geneva, Geneva, Switzerland; Swiss NCCR "LIVES-Overcoming Vulnerability: Life Course Perspectives", University of Geneva, Geneva, Switzerland.

Introduction: Vision of the human body has been shown to be key in eliciting sexual desire. However, whether the visual pattern characterizing sexual desire is different in women and men is still unclear.

Aim: To investigate the effect of gender on visual patterns triggered by an identical set of stimuli depicting attractive heterosexual couples. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.12.003DOI Listing
February 2019

Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea.

Br J Anaesth 2019 Mar 6;122(3):395-401. Epub 2018 Dec 6.

Anaesthesia and Critical Care, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK; Nottingham University Hospitals NHS Trust, Nottingham, UK.

Background: Apnoeic oxygenation can come close to matching the oxygen demands of the apnoeic patient but does not facilitate carbon dioxide (CO) elimination, potentially resulting in dangerous hypercapnia. Numerous studies have shown that high-flow nasal oxygen administration prevents hypoxaemia, and appears to reduce the rate of increase of arterial CO partial pressure (Pa), but evidence is lacking to explain these effects.

Methods: We extended a high-fidelity computational simulation of cardiopulmonary physiology to include modules allowing variable effects of: (a) cardiogenic oscillations affecting intrathoracic gas spaces, (b) gas mixing within the anatomical dead space, (c) insufflation into the trachea or above the glottis, and (d) pharyngeal pressure oscillation. Read More

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http://dx.doi.org/10.1016/j.bja.2018.11.012DOI Listing

Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications.

Br J Anaesth 2019 Mar 8;122(3):361-369. Epub 2019 Feb 8.

Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, Università degli Studi di Genova, Genova, Italy; IRCCS Ospedale Policlinico San Martino, Genova, Italy.

Background: The aim of this post hoc analysis of a large cohort study was to evaluate the association between night-time surgery and the occurrence of intraoperative adverse events (AEs) and postoperative pulmonary complications (PPCs).

Methods: LAS VEGAS (Local Assessment of Ventilatory Management During General Anesthesia for Surgery) was a prospective international 1-week study that enrolled adult patients undergoing surgical procedures with general anaesthesia and mechanical ventilation in 146 hospitals across 29 countries. Surgeries were defined as occurring during 'daytime' when induction of anaesthesia was between 8:00 AM and 7:59 PM, and as 'night-time' when induction was between 8:00 PM and 7:59 AM. Read More

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http://dx.doi.org/10.1016/j.bja.2018.10.063DOI Listing

Choosing Wisely: just because we can, does it mean we should?

Br J Anaesth 2019 Mar 8;122(3):306-310. Epub 2019 Jan 8.

Respiratory and Critical Care Research Theme, University Hospitals Southampton-University Hospitals Southampton NIHR Biomedical Research Centre, Southampton, UK; Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1016/j.bja.2018.11.025DOI Listing

Intratympanic Steroid Use for Sudden Sensorineural Hearing Loss: Current Otolaryngology Practice.

Ann Otol Rhinol Laryngol 2019 Feb 15:3489419828759. Epub 2019 Feb 15.

1 Royal National Throat, Nose and Ear Hospital, University College London Hospitals NHS Trust, London, UK.

Objective:: To investigate the current practice of intratympanic steroid (ITS) injection for sudden sensorineural hearing loss (SSNHL) in the United Kingdom and link the data with data from the United States and continental Europe.

Methods:: A survey of 21 questions was distributed to members of the British Society of Otology using an online survey platform via ENT UK. Data obtained from UK otolaryngologists (n = 171) were integrated with previously published data from other countries, including the United States (n = 63) and continental Europe (n = 908). Read More

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http://dx.doi.org/10.1177/0003489419828759DOI Listing
February 2019
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