4,415,680 results match your criteria Hospital practice 1995[Journal]


Percutaneous endoscopic gastrostomy in older patients with and without dementia: survival and ethical considerations.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Background And Aim: Notwithstanding multiple recommendations in guidelines, percutaneous endoscopic gastrostomy (PEG)-tube placement is still performed in patients with dementia. In this study we aim to investigate survival in patients with and without dementia after (PEG)-tube placement.

Methods: We conducted a retrospective multicenter study in four different hospitals in The Netherlands. Read More

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December 2018

Screening for non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Gastroenterology and Hepatology Unit, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background: The recommendation in regards to screening for non-alcoholic fatty liver disease (NAFLD) among type 2 diabetes mellitus (T2DM) patients differs in major guidelines.

Aim: To study the prevalence of NALFD and advanced fibrosis among T2DM patients.

Methods: Cross-sectional study of consecutive adult T2DM patients attending the Diabetes Clinic of a university hospital. Read More

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December 2018

Diagnostic leukapheresis for CTC analysis in breast cancer patients: CTC frequency, clinical experiences and recommendations for standardized reporting.

Cytometry A 2018 Dec;93(12):1213-1219

Faculty of the Heinrich-Heine, General, Visceral and Pediatric Surgery, University Hospital and Medical Faculty, University Düsseldorf, Düsseldorf, North Rhine-Westphalia, Germany.

Diagnostic leukapheresis (DLA) is based on continuous centrifugation that collects mononuclear cells from peripheral blood with a density of 1.055-1.08 g/ml. Read More

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December 2018

Snare resection after full-thickness resection device malfunction.

Endoscopy 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology, Beaumont Hospital, Dublin, Ireland.

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December 2018

[Innovative New Evacuation Concept with Emergency Mattresses].

Z Orthop Unfall 2018 Dec 14;156(6):723-724. Epub 2018 Dec 14.

Sicherheitsmanagement, Klinikverbund Südwest GmbH, Sindelfingen.

Indication: In-hospital patients with limited mobility are extremely vulnerable in cases of emergency or fire. In the past, several large fires in multi-story hospitals have resulted in deaths.

Methods: For this reason, we have developed an evacuation mattress that incorporates the functions of an evacuation towel with the comfort of a normal mattress. Read More

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December 2018

Association of Antenatal Depression with Clinical Subtypes of Preterm Birth.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts.

Objective:  To estimate the association between antenatal depression and spontaneous preterm birth (SPTB) relative to medically indicated preterm birth (MPTB).

Study Design:  This was a secondary analysis of a nested case-control study of preterm birth (PTB). The exposure was a clinical diagnosis of antenatal depression. Read More

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December 2018

Cardiovascular and Metabolic Risk in Women in the First Year Postpartum: Allostatic Load as a Function of Race, Ethnicity, and Poverty Status.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Internal Medicine, UCLA Geffen School of Medicine, Los Angeles, California.

Objective:  Allostatic load (AL) represents multisystem physiological "wear-and-tear" reflecting emerging chronic disease risk. We assessed AL during the first year postpartum in a diverse community sample with known health disparities.

Methods:  The Shriver National Institute for Child Health and Human Development Community Child Health Network enrolled 2,448 predominantly low-income African-American, Latina, and White women immediately after delivery of liveborn infants at ≥20 weeks' gestation, following them over time with interviews, clinical measures, and biomarkers. Read More

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December 2018

Impact of Time to Neonatal Transport on Outcomes of Transient Tachypnea of the Newborn.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan.

Objective:  To assess effects of neonatal transport on transient tachypnea of the newborn (TTN) in outborn term neonates.

Study Design:  This retrospective cohort study included 66 term neonates diagnosed with TTN and transported to the Osaka Women's and Children's Hospital neonatal intensive care unit between January 2003 and March 2018. A multivariate logistic regression analysis identified perinatal and neonatal transport factors associated with adverse short-term outcomes defined as mechanical ventilation >48 hours, continuous positive airway pressure >72 hours, pulmonary hemorrhage, and requirement for inhaled nitric oxide, thoracentesis, or surfactant replacement therapy. Read More

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December 2018

Pediatric Nurses' Knowledge of and Self-Efficacy in Breastfeeding Counseling.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Public Health, Department of Community Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Objective:  Sound breastfeeding (BF) knowledge among health professionals is vital for proper institutional support of BF mothers. This study aims to measure both BF knowledge and self-efficacy (SE) of pediatric nurses in supporting BF and to determine their associated factors.

Study Design:  A cross-sectional study was conducted in Mansoura University Children's Hospital and Mansoura New General Hospital during the period from January to March 2017. Read More

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December 2018

Associations between Maternal Exposure to Bisphenol A or Triclosan and Gestational Hypertension and Preeclampsia: The MIREC Study.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Research Center, CHU Sainte-Justine, Mother and Child University Hospital Center, Montreal, Quebec, Canada.

Background:  Little is known about the association between bisphenol A (BPA) or triclosan (TCS) exposure and hypertension in pregnancy.

Objective:  To investigate potential associations between maternal urinary concentrations of BPA or TCS and gestational hypertension (GH) and preeclampsia.

Study Design:  Among 1,909 pregnant women participating in the maternal-infant research on environmental chemicals (MIREC) study, urinary concentrations of BPA and TCS were measured in the first trimester by liquid chromatography-tandem mass spectrometry using isotope dilution. Read More

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December 2018

A Diagnostic Challenge: Prenatal Ultrasound Findings in Severe Epidermolysis Bullosa.

Ultraschall Med 2018 Dec 14;39(6):600-601. Epub 2018 Dec 14.

Ultraschallpraxis Freie Strasse, Basel, Switzerland.

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December 2018

Examination of the complexation ability of different calixarene derivatives towards [223Ra]RaCl2 in a hospital radiopharmaceutical laboratory.

Nuklearmedizin 2018 Dec 14;57(6):242-246. Epub 2018 Dec 14.

Aim: In this contribution we investigated the potential transfer of an established method for the synthesis of Ra-labelled calixarene complexes to a hospital radiopharmaceutical environment. For this purpose, commercially available [Ra]RaCl solution in pharmaceutical grade (Xofigo) was reacted with three calixarene derivatives.

Methods: A wellestablished two-phase extraction method using a two-phase solvent system was performed for complexation of the radium ions with calixarenes under slightly basic conditions. Read More

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December 2018

The Influence of Antidepressants on the Disease Course Among Patients With Crohn's Disease and Ulcerative Colitis-A Danish Nationwide Register-Based Cohort Study.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.

Background: Psychiatric comorbidity might modify the disease course adversely in patients with inflammatory bowel disease (IBD). Treatment options include antidepressants, which, apart from improving mood, have anti-inflammatory properties that might modify the disease course. This nationwide study aimed to examine the influence of antidepressants on the disease course among patients with ulcerative colitis (UC) and Crohn's disease (CD). Read More

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December 2018

Uromodulin in a pathway between decreased renal urate excretion and albuminuria.

Am J Hypertens 2018 Dec 14. Epub 2018 Dec 14.

Centre de recherche du CHUM, Montréal, Quebec, Canada.

Background: The mechanism explaining the inverse association between renal urate and albumin excretion remains unclear. First, we evaluated the impact of candidate variants in the main urate transporter genes (i.e. Read More

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December 2018

Novel endotypes in heart failure: effects on guideline-directed medical therapy.

Eur Heart J 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiology, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.

Aims: We sought to determine subtypes of patients with heart failure (HF) with a distinct clinical profile and treatment response, using a wide range of biomarkers from various pathophysiological domains.

Methods And Results: We performed unsupervised cluster analysis using 92 established cardiovascular biomarkers to identify mutually exclusive subgroups (endotypes) of 1802 patients with HF and reduced ejection fraction (HFrEF) from the BIOSTAT-CHF project. We validated our findings in an independent cohort of 813 patients. Read More

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December 2018

Pilot Studies of VOC Exposure Profiles during Surgical Operations.

Ann Work Expo Health 2018 Dec 14. Epub 2018 Dec 14.

Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan, R.O.C.

Volatile organic chemical exposure resulting from surgical operations is common in operating room personnel. The potential risk of long-term exposure to these low-level chemicals is always a concern. This study was conducted in an area hospital located in northern Taiwan to investigate the internal exposure scenario for operating room personnel. Read More

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December 2018

Prevalence and associated risk factors of periodic limb movement in sleep in two German population-based studies.

Sleep 2018 Dec 14. Epub 2018 Dec 14.

Institute of Epidemiology and Social Medicine, Westfälische Wilhelms-Universität Münster, Münster, Germany.

Study Objectives: Periodic limb movements in sleep (PLMS) are frequent motor phenomena; however, population-based data are scarce. We assessed the prevalence of PLMS and factors associated with PLMS within two German population-based cohorts, the SHIP-TREND and BiDirect.

Methods: Single-night polysomnography was performed on 1107 subjects recruited from the general population (mean age: 52. Read More

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December 2018

Cost-Effectiveness of Chimeric Antigen Receptor T-Cell Therapy in Pediatric Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia.

J Natl Cancer Inst 2018 Dec 14. Epub 2018 Dec 14.

University of California San Diego School of Medicine, UCSD School of Medicine, La Jolla, CA.

Background: Chimeric antigen receptor T-cell (CAR-T) therapy is a promising new class of cancer therapy but has a high up-front cost. We evaluated the cost-effectiveness of CAR-T therapy among pediatric patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL).

Methods: We built a microsimulation model for pediatric patients with relapsed/refractory B-ALL receiving either CAR-T therapy or standard of care. Read More

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December 2018

Tracing the Origin of Glioblastoma: Subventricular Zone Neural Stem Cells.

Neurosurgery 2019 Jan;84(1):E15-E16

Brain Tumor Center Department of Neurosurgery Lenox Hill Hospital Zucker School of Medicine at Hofstra/Northwell New York, New York.

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January 2019

Network localization of heterogeneous neuroimaging findings.

Brain 2018 Dec 14. Epub 2018 Dec 14.

Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical Center, Boston, MA, USA.

Studies of the same disease often implicate different brain regions, contributing to a perceived reproducibility crisis in neuroimaging. Here, we leverage the normative human brain connectome to test whether seemingly heterogeneous neuroimaging findings localize to connected brain networks. We use neurodegenerative disease, and specifically Alzheimer's disease, as our example as it is one of the diseases that has been studied the most using neuroimaging. Read More

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December 2018

Work Loss Before and After Diagnosis of Crohn's Disease.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.

Background: The aim of this study was to examine work loss in patients with Crohn's disease.

Methods: Using nationwide registers, we identified incident patients with Crohn's disease (2007-2010) and population comparator subjects without inflammatory bowel disease, matched by age, sex, calendar year, health care region, and education level. We assessed the number of lost workdays due to sick leave and disability pension from 5 years before to 5 years after first diagnosis of Crohn's disease or end of follow-up (September 30, 2015). Read More

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December 2018

Staphylococcus aureus Decolonization of Mice With Monoclonal Antibody Neutralizing Protein A.

J Infect Dis 2018 Dec 15. Epub 2018 Dec 15.

Department of Microbiology, University of Chicago, Illinois.

Staphylococcusaureus persistently colonizes the nasopharynx of about one-third of the human population, a key risk factor for community- and hospital-acquired invasive infections. Current strategies for S. aureus decolonization include topical and systemic administration of antibiotics, which is associated with selection for antibiotic resistance and posttreatment recolonization. Read More

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December 2018

Lower skeletal muscle mass at admission independently predicts falls and mortality three months post-discharge in hospitalised older patients.

J Gerontol A Biol Sci Med Sci 2018 Dec 14. Epub 2018 Dec 14.

Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Victoria, Australia.

Background: Approximately 10% of older adults is annually admitted to a hospital. Hospitalisation is associated with a higher risk of falls and mortality after discharge. This study aimed to identify predictors at admission for falls and mortality three months post-discharge in hospitalised older patients. Read More

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December 2018

Just the Tip: Resection of a Narcotic Catheter-Tip Granuloma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurosurgery, University of Miami, Jackson Memorial Hospital, Miami, Florida.

The catheter tip "granuloma" is a rare inflammatory mass that forms in about 3% of patients with an intradural catheter, most commonly from a morphine pump. It has also been seen with other narcotic pumps, narcotic-non-narcotic combinations, and baclofen pumps. Mass formation is associated with increased opioid dose and concentration. Read More

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December 2018

Expostats: A Bayesian Toolkit to Aid the Interpretation of Occupational Exposure Measurements.

Ann Work Expo Health 2018 Dec 14. Epub 2018 Dec 14.

Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Introduction: Interpretation of exposure measurements has evolved into a framework based on the lognormal distribution. Most available practical tools are based on traditional frequentist statistical procedures that do not satisfactorily account for censored data and are not amenable to simple probabilistic risk statements. Bayesian methods offer promising solutions to these challenges. Read More

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December 2018

Commentary: Vein of Galen Malformations: The Texas Children's Hospital Experience in the Modern Endovascular Era.

Oper Neurosurg (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York.

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December 2018

Increased incidence rate of hypothyroidism after iodine fortification in Denmark. A 20 year prospective population-based study.

J Clin Endocrinol Metab 2018 Dec 14. Epub 2018 Dec 14.

Department of Endocrinology, Aalborg University Hospital, Denmark.

Objective: To monitor the impact of a cautious iodine fortification (IF) on the incidence of overt hypothyroidism in two sub-populations with different levels of preexisting iodine deficiency (ID).

Design: A 20 years (1997-2016) prospective population-based study identified all new cases of diagnosed overt biochemical hypothyroidism in two open cohorts: a Western cohort with moderate ID (n=309,434, January 1st, 1997) and an Eastern cohort with mild ID (n=224,535, January 1st, 1997). A diagnostic algorithm was applied to all thyroid function tests performed within the study areas and possible new cases were verified individually. Read More

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December 2018

Hello from the new Editor-in-Chief.

Authors:
Marwan Bukhari

Rheumatology (Oxford) 2019 Jan;58(1):1-2

Rheumatology, University Hospitals of Morecambe Bay NHS Trust, Royal Lancaster Infirmary, Lancaster, UK.

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January 2019

Renal relapse in antineutrophil cytoplasmic autoantibody-associated vasculitis: unpredictable, but predictive of renal outcome.

Rheumatology (Oxford) 2019 Jan;58(1):103-109

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: To determine predictors of renal relapse and end-stage renal failure (ESRF) in patients with ANCA-associated vasculitis.

Methods: Data from four European Vasculitis Society randomized controlled trials, conducted roughly simultaneously between 15 March 1995 and 30 September 2002, was pooled to determine predictors of long-term renal outcome. The respective trial inclusion criteria covered the entire spectrum of disease severity. Read More

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January 2019

Moving Beyond Role-Play: Evaluating the Use of Virtual Reality to Teach Emotion Regulation for the Prevention of Adolescent Risk Behavior Within a Randomized Pilot Trial.

J Pediatr Psychol 2018 Dec 14. Epub 2018 Dec 14.

Bradley/Hasbro Children's Research Center/Rhode Island Hospital and the Warren Alpert Medical School of Brown University.

Objective: The purpose of the current pilot study was to evaluate the acceptability and preliminary impact of using immersive virtual reality environments (IVREs) paired with a brief emotion regulation and risk reduction intervention (ER + IVRE) relative to this same intervention content paired with role-plays (ER + RP).

Methods: Eighty-five adolescents attending middle school (grades 6th-8th; ages 12-15 years) in an urban northeast city were recruited and randomized to ER + IVRE (n = 44) or ER + RP (n = 41) and had complete data. Data examining acceptability, feasibility, sexual knowledge and attitudes, and ER were collected at baseline and 3 months after intervention completion. Read More

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December 2018

2018 Infectious Diseases Society of America Clinical Practice Guideline for the Management of Outpatient Parenteral Antimicrobial Therapy.

Clin Infect Dis 2019 Jan;68(1):1-4

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, and Center for Evidence-based Practice, University of Pennsylvania Health System, Philadelphia.

A panel of experts was convened by the Infectious Diseases Society of America to update the 2004 clinical practice guideline on outpatient parenteral antimicrobial therapy (OPAT) [1]. This guideline is intended to provide insight for healthcare professionals who prescribe and oversee the provision of OPAT. It considers various patient features, infusion catheter issues, monitoring questions, and antimicrobial stewardship concerns. Read More

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January 2019

A 29-Year-Old Japanese Man Returning From Indonesia With Diffuse Maculopapular Rash.

Clin Infect Dis 2019 Jan;68(1):165-167

Center for Global Health, Mito Kyodo General Hospital, University of Tsukuba.

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January 2019

Social and early life adversity and chronic health conditions among Tunisian adults.

Transl Behav Med 2018 Dec 13. Epub 2018 Dec 13.

Duluth Medical Research Institute, University of Minnesota, Duluth, MN, USA.

Early life adversities (ELAs) are shown as significant risk factors for chronic health conditions (CHCs). ELAs include multiple types of abuse such as the social abuse (peer, community, and collective violence). The purpose is to describe the relationship between childhood social abuse and chronic conditions in adulthood among a sample of adults in Tunisia and to investigate the role of obesity and tobacco use as mediators of this association. Read More

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December 2018

The Acute Impact of Hatha Yoga on Craving among Smokers Attempting to Reduce or Quit.

Nicotine Tob Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Psychology, Louisiana State University, Baton Rouge, LA, USA.

Introduction: Despite negative effects of smoking, smokers have difficulty quitting, suggesting a need for additional strategies to help them quit. A single-session hatha yoga intervention acutely reduced craving among nicotine-deprived smokers not attempting to reduce or quit, yet it is unknown if it reduces craving among those attempting to change their smoking. Thus, the current study tested the efficacy of a single-session hatha yoga intervention for acutely reducing craving among smokers attempting to reduce or quit smoking. Read More

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December 2018

Appropriate use criteria adoption for PCI at an academic medical center.

Eur Heart J 2018 Dec;39(47):4136-4138

Division of Cardiovascular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, 11100 Euclid Ave, Mailstop LKS 5038, Cleveland, Ohio, Phone: (216) 844-7760, Fax: (216) 844-8954.

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December 2018

FIFA World Cup 2018.

Eur Heart J 2018 Dec;39(47):4139-4142

Department of Medicine I, University Hospital Munich, Ludwig Maximilian University, Campus Innenstadt, Ziemssenstrasse 1, Munich, Germany.

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December 2018

Arterial and pulmonary hypertension: risk assessment and current pharmacological and interventional management.

Eur Heart J 2018 Dec;39(47):4127-4131

Imperial College and Consultant and Director of Research, Education & Development, Royal Brompton and Harefield Hospital Trust, London, UK.

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December 2018

Distinct histopathological features at diagnosis of very early onset inflammatory bowel disease.

J Crohns Colitis 2018 Dec 14. Epub 2018 Dec 14.

The Children's Hospital of Philadelphia, Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Philadelphia, PA.

Background And Aims: Children with very early onset inflammatory bowel disease represent a unique cohort, often with a severe phenotype that is refractory to conventional medications, and in some cases, have underlying primary immunodeficiencies. Prior work has identified distinct histopathological patterns in the gastrointestinal tract in patients with primary immunodeficiencies. The aim of this study is to characterize the diagnostic histological findings in patients with VEO-IBD as compared to older onset pediatric IBD and determine if there are unique pathological changes that can shed light on the driving forces of the disease, particularly immunodeficiencies. Read More

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December 2018

Effects of a single transient transfection of Ten-eleven translocation 1 catalytic domain on hepatocellular carcinoma.

PLoS One 2018 14;13(12):e0207139. Epub 2018 Dec 14.

College of Pharmacy, Nanchang University, Nanchang, Jiangxi, P.R. China.

Tumor suppressor genes (TSGs), including Ten-eleven translocation 1 (TET1), are hypermethylated in hepatocellular carcinoma (HCC). TET1 catalytic domain (TET1-CD) induces genome-wide DNA demethylation to activate TSGs, but so far, anticancer effects of TET1-CD are unclear. Here we showed that after HCC cells were transiently transfected with TET1-CD, the methylation levels of TSGs, namely APC, p16, RASSF1A, SOCS1 and TET1, were distinctly reduced, and their mRNA levels were significantly increased and HCC cells proliferation, migration and invasion were suppressed, but the methylation and mRNA levels of oncogenes, namely C-myc, Bmi1, EMS1, Kpna2 and c-fos, were not significantly change. Read More

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December 2018

Prevalence and correlates of anemia among adolescents in Nepal: Findings from a nationally representative cross-sectional survey.

PLoS One 2018 14;13(12):e0208878. Epub 2018 Dec 14.

Department of Paediatrics, the University of Melbourne, Melbourne, Australia.

Anemia is regarded as major public health problem among adolescents in Low and Middle-Income Countries (LMICs) but there is limited primary data in many countries, including Nepal. This study investigated the prevalence and correlates of anemia in a nationally representative sample of adolescents within the 2014 National Adolescent Nutrition Survey in Nepal. A total of 3780 adolescents aged 10 to 19 years were selected from a cross-sectional survey through multi-stage cluster sampling. Read More

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December 2018

Effects of early enteral bovine colostrum supplementation on intestinal permeability in critically ill patients: A randomized, double-blind, placebo-controlled study.

Nutrition 2018 Oct 12;60:106-111. Epub 2018 Oct 12.

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Objectives: In this study we sought to investigate the effect of early enteral bovine colostrum supplementation on intestinal permeability in intensive care unit (ICU)-hospitalized patients.

Methods: A total of 70 ICU-hospitalized adult patients were randomly assigned to receive a bovine colostrum supplement or placebo according to the stratified blocked randomization by age and admission category. Plasma endotoxin and zonulin concentrations were measured on days 5 and 10 of intervention. Read More

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October 2018

MiR-23a-3p acts as an oncogene and potential prognostic biomarker by targeting PNRC2 in RCC.

Biomed Pharmacother 2018 Dec 11;110:656-666. Epub 2018 Dec 11.

Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China. Electronic address:

Background: Renal cell carcinoma (RCC) is a most common kidney malignancy, with atypical symptoms in the early stage and poor outcome in the late stage. Recently, emerging evidence revealed that some miRNAs play an essential role in the tumorigenesis and progression of RCC. Therefore, the aim of this study is that understand the detailed molecular mechanism of miR-23a-3p in RCC and identify its potential clinical value. Read More

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December 2018

Stakeholder perspectives on implementing fentanyl drug checking: Results from a multi-site study.

Drug Alcohol Depend 2018 Nov 13;194:527-532. Epub 2018 Nov 13.

Department of Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, 624 N. Broadway, Hampton House 163, Baltimore, MD, USA.

Background: The opioid epidemic is one of the greatest public health crises of our times, driven increasingly by synthetic opioids such as fentanyl in the heroin supply. The implementation of drug checking in community settings has the potential to reduce the burden of fatal overdose, provide harm reduction education around safer drug consumption, and increase health access among people who use drugs (PWUD). To inform program development, we explored stakeholder opinions on drug checking technologies and implementation considerations. Read More

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November 2018

Biomechanical testing of a polycarbonate-urethane-based dynamic instrumentation system under physiological conditions.

Clin Biomech (Bristol, Avon) 2018 Dec 6;61:112-119. Epub 2018 Dec 6.

University of Cologne, Centre for Orthopaedic and Trauma Surgery, Germany.

Background: Posterior dynamic stabilization systems are developed to maintain the healthy biomechanics of the spine while providing stabilization. Numerous dynamic systems incorporate polycarbonate urethane with temperature- and moisture-dependent material properties. In the underlying study, a novel test rig is used to evaluate the biomechanical performance of a system containing polycarbonate urethane. Read More

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December 2018

Designing luminescent ruthenium prodrug for precise cancer therapy and rapid clinical diagnosis.

Biomaterials 2018 Dec 5;192:579-589. Epub 2018 Dec 5.

The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China; Department of Chemistry, Jinan University, Guangzhou, 510632, China. Electronic address:

The effective design of a targeted drug delivery system could improve the therapeutic efficacy of anticancer drugs by reducing their undesirable adsorption and toxic side effects. Here, an RGD-peptide functionalized and bioresponsive ruthenium prodrug (Ru-RGD) was designed for both cancer therapy and clinical diagnosis. This prodrug can be selectively delivered to cervical tumor sites to enhance theranostic efficacy. Read More

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December 2018

Associations between cognitive impairment and quality of life in euthymic bipolar patients.

Psychiatry Res 2018 Nov 26;271:510-515. Epub 2018 Nov 26.

Department of Psychiatry, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

During the euthymic state in bipolar disorder, cognitive functions often remain affected. Specifically, subjective and objective cognitive impairment might distinctly affect patients' quality of life (QoL); however, this question had not been examined previously in Japanese patients. Therefore, the current study investigated the associations between cognitive complaints, QoL, and objective cognitive functions. Read More

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November 2018
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Vestibular dysfunction as cortical damage with amyotrophic lateral sclerosis.

J Neurol Sci 2018 Dec 5;397:4-8. Epub 2018 Dec 5.

Department of Neurology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Background: Cortical damage in areas such as the frontal lobe is reported in amyotrophic lateral sclerosis (ALS). However, aside from executive dysfunction, the pathological significance of this cortical damage has yet to be clarified. The present study investigated the effects of cortical damage on vestibular function in ALS. Read More

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December 2018

Vertico-horizontal atlantoaxial index (VHAI): A new craniovertebral radiographic index.

Clin Neurol Neurosurg 2018 Dec 3;176:83-88. Epub 2018 Dec 3.

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Objective: The purpose of this study was to develop a new index that can reliably quantify the reduction of basilar invagination with atlantoaxial dislocation.

Patients And Methods: Between May 2012 and September 2017, 40 patients with congenital basilar invagination and atlantoaxial dislocation as well as 100 sex-and age-matched control subjects were recruited for this study. All patients underwent direct posterior reduction and fixation. Read More

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December 2018

Estimating the probability of abusive head trauma after abuse evaluation.

Child Abuse Negl 2018 Dec 11;88:266-274. Epub 2018 Dec 11.

Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States.

Background: Evidence-based, patient-specific estimates of abusive head trauma probability can inform physicians' decisions to evaluate, confirm, exclude, and/or report suspected child abuse.

Objective: To derive a clinical prediction rule for pediatric abusive head trauma that incorporates the (positive or negative) predictive contributions of patients' completed skeletal surveys and retinal exams.

Participants And Setting: 500 acutely head-injured children under three years of age hospitalized for intensive care at one of 18 sites between 2010 and 2013. Read More

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December 2018
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