3,535 results match your criteria Horseshoe Kidney


Robotic nephroureterectomy in a horseshoe kidney for upper tract urothelial carcinoma.

BMJ Case Rep 2021 Jun 9;14(6). Epub 2021 Jun 9.

Urology, East Kent Hospitals University NHS Foundation Trust, Canterbury, UK.

Upper tract urothelial carcinoma represents a small proportion (5%-10%) of all urothelial cancers. Although there are several management options, in undifferentiated or high-risk cases, surgery in the form of nephroureterectomy is the gold standard. Horseshoe kidney is the most common congenital renal fusion anomaly affecting 1 in 400-600 patients. Read More

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[Efficacy and Safety of Retrograde Ureterorenoscopic Lithotripsy for Patients with Renal or Ureteral Anatomic Abnormalities or Urinary Diversion].

Hinyokika Kiyo 2021 Apr;67(4):133-139

The Department of Urology, Ijinkai Takeda General Hospital.

Retrograde ureterorenoscopic lithotripsy is one of the first-line therapies for urolithiasis. In some cases, however, thisapproach may be difficult to adopt because of factorss uch asrenal/ureteral anatomic abnormalities or urinary diversion. This study aims to investigate the safety and efficacy of retrograde ureterorenoscopic lithotripsy in patients with the above-mentioned conditions. Read More

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Long-term outcomes after pyeloplasty for pelvi-ureteric junction obstruction in adults associated with renal congenital anomalies: Age, sex and renal function matched analysis.

Arab J Urol 2020 Sep 2;19(2):173-178. Epub 2020 Sep 2.

Department of Urology, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

: To assess the long-term outcomes after pyeloplasty for pelvi-ureteric junction obstruction (PUJO) associated with renal anomalies. : Data were collected for patients after pyeloplasty for PUJO associated with renal anomalies and analysed retrospectively. Long-term functional success was evaluated by comparing the renographic split renal function (SRF) and glomerular filtration rate (GFR) at last follow-up with baseline values. Read More

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September 2020

Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke.

BMC Med 2021 Jun 9;19(1):131. Epub 2021 Jun 9.

Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.

Background: Acute ischemic stroke (AIS) is a serious cause of mortality and disability. AIS is a serious cause of mortality and disability. Early diagnosis of atherosclerosis, which is the major cause of AIS, allows therapeutic intervention before the onset, leading to prevention of AIS. Read More

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The correlations of prenatal renal ultrasound abnormalities with pathogenic CNVs in a large Chinese cohort.

Ultrasound Obstet Gynecol 2021 Jun 5. Epub 2021 Jun 5.

Department of Genetic and Metabolic Central Laboratory, Guangxi Maternal and Child Health Hospital, Guangxi Birth Defects Prevention and Control Institute, No59, Xiangzhu Road, Nanning, China.

Objective: Our retrospective study aimed to assess the prenatal clinical utility of chromosome microarray (CMA) and the correlations of pathogenic copy number variants (CNVs) with different types of renal abnormalities detected by prenatal ultrasound screening and help to guide the optimal management for the relative late invasive diagnostic approach for renal abnormalities.

Methods: Fetus at 14-36 weeks of gestation were routinely screened for renal and other structural abnormalities at the Maternal and Child Health Hospital of Guangxi Autonomous Region. 877 fetuses with abnormal renal sonographic findings identified over a period of more than five years were subjected for CMA analysis using materials obtained from chorionic villi sampling, amniocentesis or cordocentesis. Read More

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Primary Renal Well-Differentiated Neuroendocrine Tumor (Carcinoid) in a Horseshoe Kidney.

Mayo Clin Proc 2021 06;96(6):1687-1688

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

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Laparoscopic heminephrectomy in a horseshoe kidney affected by xanthogranulomatous pyelonephritis: A modified approach.

Urol Case Rep 2021 Sep 15;38:101717. Epub 2021 May 15.

Department of Medicine, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.

Horseshoe kidney (HSK) is a common congenital kidney anomaly that is encountered frequently by urologists. It is rare for HSK to be affected by xanthogranulomatous pyelonephritis (XGP), a potentially life-threatening condition. The standard of care for XGP is open nephrectomy, but recently a few case reports have been published showing the feasibility of minimally invasive surgery to deal with XGP. Read More

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September 2021

TARP syndrome associated with renal malformation and optic nerve atrophy.

BMJ Case Rep 2021 May 24;14(5). Epub 2021 May 24.

Department of Pediatrics at Fundación Santa Fé de Bogotá, Hospital Universitario de la Fundacion Santa Fe de Bogota, Bogota, Colombia.

Talipes equinovarus, atrial septal defect, Robin sequence and persistent left superior vena cava (TARP) syndrome is a congenital disease caused by mutations in the RBBM10 gene. It has a low prevalence and a high rate of mortality in the neonatal stage. In this case report, we present a case of a 32-week gestational age preterm newborn with a prenatal diagnosis of intrauterine growth restriction, with a persistent left superior vena cava, interatrial communication and a horseshoe kidney. Read More

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A Novel Surgical Approach for the Management of Cloacal Exstrophy with a Giant Omphalocele.

European J Pediatr Surg Rep 2021 Jan 18;9(1):e41-e45. Epub 2021 May 18.

Division of Colorectal and Pelvic Reconstructive Surgery, Children's National Hospital, Washington, District of Columbia, United States.

Cloacal exstrophy is a rare malformation that presents as a lower midline abdominal wall defect which affects the gastrointestinal and genitourinary systems. The components of cloacal exstrophy characteristically include omphalocele, exstrophy of perineal structures, and imperforate anus. Most of these patients also have renal anomalies such as pelvic kidney, fused kidneys, or solitary kidneys. Read More

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January 2021

Retroperitoneoscopic single-instrument horseshoe nephrectomy for dilated non-functioning right moiety.

J Pediatr Urol 2021 Apr 30. Epub 2021 Apr 30.

Paediatric Urology, Evelina London Children's Hospital, London, United Kingdom; Stem Cells & Regenerative Medicine Section, Developmental Biology & Cancer Programme, UCL Institute of Child Health. Electronic address:

Retroperitoneoscopic horseshoe nephrectomy is an uncommon procedure, in particular in the paediatric practice. We present a procedure carried out via a posterior approach with a single working port in a 20 months old boy. The video goes through the technical aspect, from the positioning of the patient and the port insertion, to the end of procedure. Read More

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Supine tubeless PCNL in horseshoe kidney (a series of cases).

Urologia 2021 May 19:3915603211015546. Epub 2021 May 19.

Department of Urology, Institute of Post Graduate Medical Education and Research & SSKM Hospital, WB, India.

Objective: Objective of this case series is accurate access to the respective calyx with stone in horseshoe kidney while performing percutaneous nephrolithotmy in supine position. Reducing operative time and anaesthetic morbidity while performing percutaneous nephrolithotomy in horseshoe kidney with nephrolithiasis in supine position.

Materials And Methods: Four patient with one having bilateral renal calculi with horshoe kidney were selected randomly. Read More

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Open transperitoneal partial nephrectomy in a horseshoe kidney.

BMJ Case Rep 2021 May 14;14(5). Epub 2021 May 14.

Geisinger Northeast Urology Department, Wilkes-Barre, Pennsylvania, USA.

We report the case of a 50-year-old Tibetan man who presented to an outpatient urology clinic after abdominal ultrasound for poorly defined abdominal pain demonstrated horseshoe kidney (HK) with a right moiety ~3.7 cm mass further characterised using contrast-enhanced CT scan (CECT). This dedicated imaging confirmed HK with a heterogeneously enhancing right upper pole 3. Read More

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Partial open tumorectomy for a renal tumor in a horseshoe kidney with a close contact with the vena cava: A case report.

Int J Surg Case Rep 2021 May 27;82:105923. Epub 2021 Apr 27.

Urology Department, Charles Nicolle Hospital, Tunis, Tunisia.

Introduction And Importance: Horseshoe kidney has unique anatomical features, such as a complex blood supply. We report a patient with renal tumor in a horseshoe kidney in close contact with the vena cava, who underwent open tumorectomy.

Case Presentation: A 72-year-old woman was referred to our hospital with a 4-cm enhancing mid-pole mass in the right moiety of a horseshoe kidney. Read More

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Horseshoe kidney leading to ERCP failure; innovative use of guide wire during laparoscopic CBD exploration: A case report.

Int J Surg Case Rep 2021 May 29;82:105927. Epub 2021 Apr 29.

Department of General Surgery, Mata Chanan Devi Hospital, New Delhi, India.

Introduction: Horseshoe kidneys are the most common fusion defect of the kidneys, which amounts to about 0.25% of the population. They are usually asymptomatic and are often identified incidentally. Read More

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Variants in the degron of AFF3 are associated with intellectual disability, mesomelic dysplasia, horseshoe kidney, and epileptic encephalopathy.

Am J Hum Genet 2021 May;108(5):857-873

GeneDx, Gaithersburg, MD 20877, USA.

The ALF transcription factor paralogs, AFF1, AFF2, AFF3, and AFF4, are components of the transcriptional super elongation complex that regulates expression of genes involved in neurogenesis and development. We describe an autosomal dominant disorder associated with de novo missense variants in the degron of AFF3, a nine amino acid sequence important for its binding to ubiquitin ligase, or with de novo deletions of this region. The sixteen affected individuals we identified, along with two previously reported individuals, present with a recognizable pattern of anomalies, which we named KINSSHIP syndrome (KI for horseshoe kidney, NS for Nievergelt/Savarirayan type of mesomelic dysplasia, S for seizures, H for hypertrichosis, I for intellectual disability, and P for pulmonary involvement), partially overlapping the AFF4-associated CHOPS syndrome. Read More

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Confirmation of Xp22.11 Duplication as a Germline Susceptibility Alteration in a Wilms Tumor Arising in Horseshoe Kidney.

Fetal Pediatr Pathol 2021 May 7:1-6. Epub 2021 May 7.

The Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.

Background: There is strong evidence of a genetic contribution to Wilms tumor, such as gene variation or epigenetic changes at chromosome locus 11p15. A previous genome wide association study (GWAS) of Wilms tumor identified other significant association loci including Xp22. A 4-year-old girl developed a Wilms tumor of the left isthmus of a horseshoe kidney. Read More

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Surgical management of horseshoe kidney tumors. Literature review and analysis of two cases.

Actas Urol Esp (Engl Ed) 2021 May 3. Epub 2021 May 3.

Servicio de Urología, Hospital General Universitario Gregorio Marañón, Madrid, España.

Introduction: The horseshoe kidney is a rare congenital anomaly in the general population that combines renal ectopia, malrotation and abnormal vascular supply. The most frequently developed tumor in this case is renal cell carcinoma (50%). One of its main characteristics is great anatomical variation, especially in terms of vascular structures. Read More

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Synthesis and Biological Screening of New Cyano-Substituted Pyrrole Fused (Iso)Quinoline Derivatives.

Molecules 2021 Apr 3;26(7). Epub 2021 Apr 3.

Department of Chemistry, Faculty of Chemistry, Alexandru Ioan Cuza University of Iași, 11 Carol I, 700506 Iași, Romania.

Several new cyano-substituted derivatives with pyrrolo[1,2-]quinoline and pyrrolo[2,1-]isoquinoline scaffolds were synthesized by the [3 + 2] cycloaddition of (iso)quinolinium ylides to fumaronitrile. The cycloimmonium ylides reacted in situ as 1,3-dipoles with fumaronitrile to selectively form distinct final compounds, depending on the structure of the (iso)quinolinium salt. Eleven compounds were evaluated for their anticancer activity against a panel of 60 human cancer cell lines. Read More

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Left-to-right crossed fused renal ectopia with pyelonephritis mimicking appendix mass.

Urol Ann 2021 Jan-Mar;13(1):73-75. Epub 2021 Jan 19.

Urology Division, Department of Surgery, Edo University, Iyamho, Edo State, Nigeria.

Crossed fused renal ectopia (CFRE) is an uncommon developmental anomaly of the genitourinary system whereby the two kidneys are located on the same side of the body and joined together, while the ureter of the ectopic kidney still enters the bladder in its normal side. CFRE has variable clinical presentations and usually discovered incidentally when patients are investigated for abdominal complaints. Treatment may be conservative when renal function is preserved with no associated symptomatic urological complications. Read More

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January 2021

Living-Donor Kidney Transplantation With Laparoscopic Nephrectomy From a Donor With Horseshoe Kidney: A Case Report.

Transplant Proc 2021 May 21;53(4):1257-1261. Epub 2021 Apr 21.

Department of Surgery, Japan Community Health Care Organization Sendai Hospital, Sendai, Miyagi, Japan.

Background: In living-donor kidney transplantation, laparoscopic nephrectomy from a donor has become widespread. However, more careful treatment is required for nephrectomy from a donor with horseshoe kidney. This report presents an interesting surgical case of laparoscopic nephrectomy from a donor with horseshoe kidney. Read More

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Construction and immune efficacy of recombinant Lactobacillus casei expressing OmpAI of Aeromonas veronii C5-I as molecular adjuvant.

Microb Pathog 2021 Jul 21;156:104827. Epub 2021 Apr 21.

College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China. Electronic address:

Despite advancements in diagnosis and control, Aeromonas infections are considered the leading cause of economic aquaculture loss. In this study, to enhance DNA vaccine efficacy against Aeromonas infections, a fused DNA fragment (1504 bp) of the OmpAI gene from Aeromonas veronii (A. veronii) combined with the C5-I gene from the common carp was generated with splicing by overlapping PCR (SOE-PCR) and expressed in Lactobacillus casei strain CC16. Read More

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Laparoscopic transposition for crossing vessels (vascular hitch) in pure extrinsic pelvic-ureteric junction obstruction: a successful case report of a 2-year-old infant with horseshoe kidney.

Surg Case Rep 2021 Apr 23;7(1):103. Epub 2021 Apr 23.

Department of Pediatric Surgery, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Pediatric hydronephrosis induced by pelvic-ureteric junction obstruction (PUJO) is treated by dismembered pyeloplasty (DP) via open and laparoscopic surgery. The etiology of PUJO involves both intrinsic stenosis and extrinsic compression of crossing vessels (CVs). PUJO owing to CVs is also treated by DP, as there is no consensus concerning this vascular condition. Read More

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Cytochrome C with peroxidase-like activity encapsulated inside the small DPS protein nanocage.

J Mater Chem B 2021 04 22;9(14):3168-3179. Epub 2021 Mar 22.

Department of Chemistry, Indiana University, 800 E Kirkwood Ave., Bloomington, Indiana 47405, USA.

Nature utilizes self-assembled protein-based structures as subcellular compartments in prokaryotes to sequester catalysts for specialized biochemical reactions. These protein cage structures provide unique isolated environments for the encapsulated enzymes. Understanding these systems is useful in the bioinspired design of synthetic catalytic organelle-like nanomaterials. Read More

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Diagnosis, Management, and Challenges in Synchronous Bilateral Wilms Tumor in a Horseshoe Kidney: A Case Report.

J Pediatr Hematol Oncol 2021 Apr 21. Epub 2021 Apr 21.

Departments of Pediatric Hematology and Oncology Pediatric Surgery Pediatric Radiology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.

Horseshoe kidney (HK) refers to a congenital malformation that results from fusion of both the kidneys at one pole, and is the most common renal fusion defect with an incidence of 1 in 400 to 600 individuals. Synchronous bilateral development of Wilms tumor (WT) in an HK is extremely rare. Here, we present a case of synchronous bilateral WT in an HK in an 18-month-old girl. Read More

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Homogeneous tumor targeting with a single dose of HER2-targeted albumin-binding domain-fused nanobody-drug conjugates results in long-lasting tumor remission in mice.

Theranostics 2021 13;11(11):5525-5538. Epub 2021 Mar 13.

Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

The non-homogenous distribution of antibody-drug conjugates (ADCs) within solid tumors is a major limiting factor for their wide clinical application. Nanobodies have been shown to rapidly penetrate into xenografts, achieving more homogeneous tumor targeting. However, their rapid renal clearance can hamper their application as nanobody drug conjugates (NDCs). Read More

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Horseshoe Kidney Complicated by Xanthogranulomatous Pyelonephritis in a Young Girl: A Case Report and Review of the Literature.

Acta Medica (Hradec Kralove) 2021 ;64(1):60-63

Institut of Pathology, SRH Wald Klinikum, Gera, Germany.

The cases of horseshoe kidney presented by xanthogranulomatous pyelonephritis are very rare. In this study, the case of XGP developing in HSK in a young female patient was presented due to its rare incidence and the previously reported cases were reviewed, as well. The patient, who has end-stage renal disease and was under treatment, admitted to the clinic for preemptive kidney transplantation. Read More

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January 2021

Robotic assisted laparoscopic prostatectomy in a patient with prostate cancer and complex urinary tract malformation.

Urol Case Rep 2021 Sep 17;38:101613. Epub 2021 Mar 17.

Southend University Hospital, Mid and South Essex NHS Foundation Trust, UK.

We present a case of prostate cancer with abnormal renal and ureteric anatomy who underwent robotic assisted laparoscopic prostatectomy. This is a 59-year-old European patient who presented with lower urinary tract symptoms (LUTS) and pelvic pain. Investigations revealed prostate cancer as well as a supernumerary right kidney and an atrophic horseshoe left kidney draining into the left seminal vesicle. Read More

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September 2021

Three-dimensional Reconstruction of Renal Vascular Tumor Anatomy to facilitate accurate preoperative planning of partial nephrectomy.

Biomedicine (Taipei) 2020 1;10(4):36-41. Epub 2020 Dec 1.

College of Medicine, China Medical University, Taichung, 40402, Taiwan.

Objectives: To evaluate the role of three-dimensional (3D) reconstruction tumors and vessels of the kidneys in aiding the preoperative planning of partial nephrectomy.

Materials And Methods: Patients with renal tumors to be treated with partial nephrectomy were included. Each patient underwent a preoperative computed tomography (CT) survey, and the reconstruction of each patient's 3D arteriography and 3D surface-rendered tumor was performed based on the CT images for preoperative surgical planning. Read More

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December 2020

Application of three-dimensional image reconstruction technology based on high-resolution CT in pyeloplasty.

Transl Androl Urol 2021 Mar;10(3):1314-1320

Fifth Medical Centre of Chinese PLA General Hospital, Beijing, China.

Background: Three-dimensional (3D) image reconstruction technology is widely used in surgical operations for its intuitive visualization. Pyeloplasty requiresprecise cutting and suturing. The reconstruction technology can accurately determine the location and scope of the stenosis at the junction of the renal pelvis and ureter and the relationship with the surrounding vasculature. Read More

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