3,683 results match your criteria Horseshoe Kidney


State of the Science for Kidney Disorders in Phelan-McDermid Syndrome: UPK3A, FBLN1, WNT7B, and CELSR1 as Candidate Genes.

Genes (Basel) 2022 Jun 10;13(6). Epub 2022 Jun 10.

Healthcare Genetics Program, School of Nursing, Clemson University, Clemson, SC 29634, USA.

Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder caused by chromosomal rearrangements affecting the 22q13.3 region or by pathogenic variants. The scientific literature suggests that up to 40% of individuals with PMS have kidney disorders, yet little research has been conducted on the renal system to assess candidate genes attributed to these disorders. Read More

View Article and Full-Text PDF

NMR-Based Metabolomics in Differential Diagnosis of Chronic Kidney Disease (CKD) Subtypes.

Metabolites 2022 May 28;12(6). Epub 2022 May 28.

Department of Pharmacy, University of Patras, 26504 Patras, Greece.

Chronic Kidney Disease (CKD) is considered as a major public health problem as it can lead to end-stage kidney failure, which requires replacement therapy. A prompt and accurate diagnosis, along with the appropriate treatment, can delay CKD's progression, significantly. Herein, we sought to determine whether CKD etiology can be reflected in urine metabolomics during its early stage. Read More

View Article and Full-Text PDF

Is there a correlation between urolithiasis in horseshoe kidneys and isthmus thickness or renal angulation?

Urologia 2022 Jun 22:3915603221104789. Epub 2022 Jun 22.

Department of Radiology, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.

Background: Stone disease is a common complication of horseshoe kidneys (HSK). There are currently limited studies that examine the relationship between HSK anatomy and stone formation. We aim to determine if there is such an association by measuring the isthmus size and renal angulation in both stone and non-stone forming HSK using computed tomography (CT). Read More

View Article and Full-Text PDF

Laparoscopic nephron-sparing surgery for horseshoe kidney complicated with renal hemangioma: a case report and literature review.

CEN Case Rep 2022 Jun 21. Epub 2022 Jun 21.

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing, Dongcheng, Beijing, 100730, China.

In very rare cases, horseshoe kidney can present simultaneously with renal hemangioma. Nephron-sparing surgery (NSS) is a minimally invasive surgical procedure for horseshoe kidney with tumor, but it is difficult to operate and has not been reported. We report a 71-year-old female with imaging examination revealed an unexpected horseshoe kidney malformation and a cystic mass in the right kidney before her bladder cancer surgery. Read More

View Article and Full-Text PDF

Intraoperative indocyanine green fluorescence navigation in a robot-assisted partial nephrectomy for a large renal cell carcinoma in a horseshoe kidney.

BMJ Case Rep 2022 Jun 20;15(6). Epub 2022 Jun 20.

Urology, Barwon Health, Geelong, Victoria, Australia.

A man in his 60s was referred to the urology department with an incidental finding of large 75 mm mass within a horseshoe kidney. CT imaging highlighted the well-known aberrant arterial anatomy seen in horseshoe kidney which often causes significant surgical challenges.After careful preoperative planning, the mass was resected successfully during a robot-assisted partial nephrectomy. Read More

View Article and Full-Text PDF

Expressing the Infectious Pancreatic Necrosis Virus VP2 Protein Retains Its Immunostimulatory Properties and Induces a Specific Antibody Response.

Front Immunol 2022 1;13:888311. Epub 2022 Jun 1.

Fish Immunology and Pathology Group, Animal Health Research Centre (CISA), National Agricultural and Food Research and Technology Institute (INIA), Spanish National Research Council (CSIC), Madrid, Spain.

has been documented in the past years as an effective probiotic for different aquacultured species, with recognized beneficial effects on water quality, fish growth and immune status. Furthermore, its potential as a vaccine adjuvant has also been explored in different species. In the current work, we have used spores as delivery vehicles for the presentation of the VP2 protein from infectious pancreatic necrosis virus (IPNV). Read More

View Article and Full-Text PDF

A novel nanoluciferase transgenic reporter measures proteinuria in zebrafish.

Kidney Int 2022 Jun 15. Epub 2022 Jun 15.

Wellcome Centre for Cell-Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

The zebrafish is an important animal system for modelling human diseases. This includes kidney dysfunction as the embryonic kidney (pronephros) shares considerable molecular and morphological homology with the human nephron. A key clinical indicator of kidney disease is proteinuria, but a high-throughput readout of proteinuria in the zebrafish is currently lacking. Read More

View Article and Full-Text PDF

Ascorbate peroxidase-mediated in situ labelling of proteins in secreted exosomes.

J Extracell Vesicles 2022 Jun;11(6):e12239

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.

The extracellular vesicle exosome mediates intercellular communication by transporting macromolecules such as proteins and ribonucleic acids (RNAs). Determining cargo contents with high accuracy will help decipher the biological processes that exosomes mediate in various contexts. Existing methods for probing exosome cargo molecules rely on a prior exosome isolation procedure. Read More

View Article and Full-Text PDF

[Scutellarin alleviates lipopolysaccharide-induced renal injury via mediating cysteine-rich protein 61-connective tissue growth factor-nephroblastoma overexpressed gene 1 expression to inhibit nuclear factor-κB signaling pathway].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2022 Apr;34(4):400-406

Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China.

Objective: To explore the protective effect and mechanism of scutellarin (Scu) on sepsis associated-acute kidney injury (SA-AKI).

Methods: (1) In vivo experiment: 36 male C57BL/6 mice were divided into normal saline (NS) control group, lipopolysaccharide (LPS) induced SA-AKI model group (LPS group), 20 mg/kg Scu control group (Scu 20 control group), and 5, 10, 20 mg/kg Scu pretreatment groups by random number table with 6 mice in each group. The SA-AKI model was reproduced by intraperitoneal injection of 10 mg/kg LPS. Read More

View Article and Full-Text PDF

Bilateral Juvenile Nasopharyngeal Angiofibroma with Hepatoblastoma and Horseshoe kidney: Implication of common molecular signalling?

Int Forum Allergy Rhinol 2022 Jun 11. Epub 2022 Jun 11.

Otorhinolaryngology, Skull Base Surgery Unit, Department of Otorhinolaryngology, Christian Medical College, Vellore, Tamil Nadu, India.

View Article and Full-Text PDF

Novel Drug Delivery Technologies and Targets for Renal Disease.

Hypertension 2022 Jun 2:101161HYPERTENSIONAHA12217944. Epub 2022 Jun 2.

the Department of Neurology, University of Mississippi Medical Center, Jackson. (G.L.B.).

The burden of acute and chronic kidney diseases to the health care system is exacerbated by the high mortality that this disease carries paired with the still limited availability of comprehensive therapies. A reason partially resides in the complexity of the kidney, with multiple potential target cell types and a complex structural environment that complicate strategies to protect and recover renal function after injury. Management of both acute and chronic renal disease, irrespective of the cause, are mainly focused on supportive treatments and renal replacement strategies when needed. Read More

View Article and Full-Text PDF

A Look inside the Replication Dynamics of SARS-CoV-2 in Blyth's Horseshoe Bat () Kidney Cells.

Microbiol Spectr 2022 May 31:e0044922. Epub 2022 May 31.

Virology Unit, Institut Pasteur du Cambodgegrid.418537.c, Institut Pasteur International Network, Phnom Penh, Cambodia.

Bats are considered the natural reservoir of numerous emerging viruses such as severe acute respiratory syndrome coronaviruses (SARS-CoVs). There is a need for immortalized bat cell lines to culture and investigate the pathogenicity, replication kinetics, and evolution of emerging coronaviruses. We illustrate the susceptibility and permissiveness of a spontaneously immortalized kidney cell line (Rhileki) from Blyth's horseshoe bat () to SARS-CoV-2 virus, including clinical isolates, suggesting a possible virus-host relationship. Read More

View Article and Full-Text PDF

Horseshoe Kidney in a Patient with Leriche Syndrome.

J Coll Physicians Surg Pak 2022 Apr;32(4):S41-S43

Department of Cardiovascular Surgery, Ankara City Hospital, Ankara, Turkey.

Horseshoe kidney (HSK) is one of the most common congenital renal fusion anomalies. Difficulties are encountered during surgery of aortic diseases associated with this anomaly. A 47-year male presented to the Outpatient Clinic with one-year history of intermittent claudication in 20 meters. Read More

View Article and Full-Text PDF

Promotion of Cyst Formation from a Renal Stem Cell Line Using Organ-Specific Extracellular Matrix Gel Format Culture System.

Gels 2022 May 19;8(5). Epub 2022 May 19.

Department of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.

Researchers have long awaited the technology to develop an in vitro kidney model. Here, we establish a rapid fabricating technique for kidney-like tissues (cysts) using a combination of an organ-derived extracellular matrix (ECM) gel format culture system and a renal stem cell line (CHK-Q cells). CHK-Q cells, which are spontaneously immortalized from the renal stem cells of the Chinese hamster, formed renal cyst-like structures in a type-I collagen gel sandwich culture on day 1 of culture. Read More

View Article and Full-Text PDF

[Electroacupuncture of "Biaoben acupoints" relieves kidney injury by suppressing oxidative stress in diabetic nephropathy rats].

Zhen Ci Yan Jiu 2022 May;47(5):435-42

School of Acupuncture-moxibustion and Orthopedics and Traumatology, Hubei University of Chinese Medicine, Wuhan 430061, China.

Objective: To observe the effect of electroacupuncture (EA) of combined "Biao"- and "Ben"-acupoint (for treating symptoms and root causes of the disease, respectively) on the expression of kidney forkhead box O1 (FoxO1) and peroxi-some proliferator-activated receptor-γ coactivator-1α (PGC-1α) in diabetic nephropathy (DN) rats, so as to explore its potential mechanisms underlying improvement of DN.

Methods: Wistar rats were randomly divided into normal control (=10), DN model (=12), EA (=11), EA+inhibitor (AS1842856 targeting FoxO1, =11) and inhibitor (=11) groups. The DN model was established by high fat and high glucose diet for 6 weeks and intraperitoneal injection of streptozotocin (55 mg/kg). Read More

View Article and Full-Text PDF

Specific bFGF targeting of KIM-1 in ischemic kidneys protects against renal ischemia-reperfusion injury in rats.

Regen Biomater 2022 12;9:rbac029. Epub 2022 May 12.

Department of Human Anatomy, Histology and Embryology, School of Basic Medicine, Qingdao University, Qingdao 266071, China.

Renal ischemia-reperfusion (I/R) injury is one of the major causes of acute kidney injury. However, there is still no effective treatment for this disease. Basic fibroblast growth factor (bFGF) has been reported to be beneficial for recovery from ischemic diseases. Read More

View Article and Full-Text PDF

A dual conditional CRISPR-Cas9 system to activate gene editing and reduce off-target effects in human stem cells.

Mol Ther Nucleic Acids 2022 Jun 27;28:656-669. Epub 2022 Apr 27.

Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20814, USA.

The CRISPR-Cas9 system has emerged as a powerful and efficient tool for genome editing. An important drawback of the CRISPR-Cas9 system is the constitutive endonuclease activity when Cas9 endonuclease and its sgRNA are co-expressed. This constitutive activity results in undesirable off-target effects that hinder studies using the system, such as probing gene functions or its therapeutic use in humans. Read More

View Article and Full-Text PDF

Bone Mineral Density T-Score is an Independent Predictor of Major Blood Loss in Adult Spinal Deformity Surgery.

Global Spine J 2022 May 24:21925682221097912. Epub 2022 May 24.

Department of Orthopaedic Surgery, 1466The Johns Hopkins University, Baltimore, MD, USA.

Study Design: Retrospective Cohort Study.

Objective: The purpose of this study was to determine the effect of low bone mineral density (BMD), as assessed by preoperative Dual-energy X-ray Absorptiometry (DEXA) scans, on intraoperative blood loss following adult spinal deformity (ASD) surgery.

Methods: Patients who received spinal fusion for ASD (>5 levels fused) at a single academic center from 2010-2018 were included in this study. Read More

View Article and Full-Text PDF

Targeted ubiquitination of sensory neuron calcium channels reduces the development of neuropathic pain.

Proc Natl Acad Sci U S A 2022 05 13;119(20):e2118129119. Epub 2022 May 13.

Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, NY 10032.

Neuropathic pain caused by lesions to somatosensory neurons due to injury or disease is a widespread public health problem that is inadequately managed by small-molecule therapeutics due to incomplete pain relief and devastating side effects. Genetically encoded molecules capable of interrupting nociception have the potential to confer long-lasting analgesia with minimal off-target effects. Here, we utilize a targeted ubiquitination approach to achieve a unique posttranslational functional knockdown of high-voltage-activated calcium channels (HVACCs) that are obligatory for neurotransmission in dorsal root ganglion (DRG) neurons. Read More

View Article and Full-Text PDF

New strategy for the design, production and pre-purification of chimeric peptide with immunomodulatory activity in Salmosalar.

Fish Shellfish Immunol 2022 Jun 10;125:120-127. Epub 2022 May 10.

Biotechnology and Biopharmaceuticals Laboratory, Departamento de Fisiopatología, Facultad de Ciencias Biológicas, Universidad de Concepción. Víctor Lamas 1290, P.O. Box 160-C, Concepción, Chile. Electronic address:

The intensive salmon farming is associated with massive outbreaks of infections. The use of antibiotics for their prevention and control is related to damage to the environment and human health. Antimicrobial peptides (AMPs) have been proposed as an alternative to the use of antibiotics for their antimicrobial and immunomodulatory activities. Read More

View Article and Full-Text PDF

Soft Tissue and Visceral Organ Sarcomas With BCOR Alterations.

J Pediatr Hematol Oncol 2022 Jul 4;44(5):195-200. Epub 2022 May 4.

Departments of Pediatrics.

Sarcomas with BCOR alteration are a heterogenous group characterized by changes including internal tandem duplications (ITDs) and recurring fusions with CCNB3, ZC3H7B, and other rare partners. With widespread genomic testing, these alterations are now associated with histologies such as Ewing-like sarcoma (BCOR::CCNB3), high-grade endometrial stromal sarcoma (ZC3H7B::BCOR), and clear cell sarcoma of kidney (BCOR-ITD). BCOR altered sarcomas of soft tissues and organs were identified through PubMed using keywords "Sarcoma (AND) BCOR" from 2005 through October 2021. Read More

View Article and Full-Text PDF

Optimal patient position for percutaneous nephrolithotomy in horseshoe kidneys: Traditional prone or supine?

Actas Urol Esp (Engl Ed) 2022 Apr 28. Epub 2022 Apr 28.

Departamento de Urología, Bakirkoy Hospital de Formación e Investigación Sadi Konuk, Universidad de Ciencias de la Salud, Istanbul, Turkey.

Objective: Although it was stated that supine percutaneous nephrolithotomy (PCNL) was associated with relatively shorter surgical times and comparable success and complication rates, there is no consensus in the current literature concerning the safety and efficacy of supine PCNL in patients with horseshoe kidneys. We aimed to compare supine and prone PCNL regarding safety and efficacy in patients with horseshoe kidneys.

Methods: Data of the patients with horseshoe kidneys who underwent PCNL for renal stones larger than 2 cm between January 2010 and May 2021 were retrospectively reviewed. Read More

View Article and Full-Text PDF

Delineating and sparing functional nephrons for radiotherapy in the case of lymphoma with polycystic kidney disease.

Cancer Treat Res Commun 2022 21;31:100566. Epub 2022 Apr 21.

Department of Radiation Oncology, National Center for Cancer Care & Research (NCCCR), Hamad Medical Corporation, Doha, Qatar.

Purpose: It is imperative to spare functioning kidneys from high radiation doses when they are near enough to radiotherapy (RT) target volumes in patients with polycystic kidney disease (PKD). To achieve this intent, we designed the unique approach that we report here.

Methods And Materials: The patient who has PKD, presented with B-cell lymphoma involving paraaortic lymph nodes. Read More

View Article and Full-Text PDF

Identification, functional characterization and expression pattern of myeloid differentiation factor 88 (MyD88) in Nibea albiflora.

Fish Shellfish Immunol 2022 May 25;124:380-390. Epub 2022 Apr 25.

National and Provincial Joint Laboratory of Exploration and Utilization of Marine Aquatic Genetic Resources, National Engineering Research Center of Marine Facilities Aquaculture, Zhejiang Ocean University, Zhoushan, 316022, PR China. Electronic address:

Myeloid differentiation factor 88 (MyD88), composed of an N-terminal death domain and a C-terminal Toll/interleukin (IL)-IR homology domain, is a key connector protein in the TLR signal transduction pathway. In this study a novel isoform of MyD88 in Nibea albiflora (named as NaMyD88) was identified and functionally characterized (GenBank accession no. MN384261. Read More

View Article and Full-Text PDF

Congenital venous anomalies associated with retrocaval ureter: evaluation using computed tomography.

Folia Morphol (Warsz) 2022 Apr 12. Epub 2022 Apr 12.

Department of Radiology, Tokai University School of Medicine, Isehara-si, Japan.

Background: Retrocaval ureter is a rare congenital anomaly resulting from anomalous development of inferior vena cava (IVC) and not from anomalous of the ureter. The anomaly always occurs on the right side due to regression of right supracardinal vein and persistence of right posterior cardinal vein. Retrocaval ureter tends to be associated with various vena cava anomalies because of the embryogenesis. Read More

View Article and Full-Text PDF

Venous supply of horseshoe kidneys and normal kidneys: an angio-MSCT-based study.

Folia Morphol (Warsz) 2022 Apr 12. Epub 2022 Apr 12.

Department of Radiological and Isotopic Diagnosis and Therapy, Medical University of Lodz, Poland.

Background: Horseshoe kidney is a common developmental anomaly which can be associated with many atypical anatomical variants of blood supply. The aim of this study was to identify the anatomical variants of renal veins supplying horseshoe kidney, with particular emphasis on their relationship with the arterial system.

Materials And Methods: The analysis included 94 patients with horseshoe kidney (HSK) and 248 persons with normal kidneys (NK). Read More

View Article and Full-Text PDF

Pathologic Findings and Management of Renal Mass in Horseshoe Kidneys.

Urology 2022 Apr 9. Epub 2022 Apr 9.

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH. Electronic address:

Objectives: To evaluate the management, surgical outcomes, and pathological findings in patients with tumor in a horseshoe-kidney (HK). HK patients present unique challenges due to aberrant vascular anatomy and risk of renal insufficiency. We hypothesized that many tumors in this setting may be indolent or benign. Read More

View Article and Full-Text PDF

Stereotactic radiotherapy for brain oligometastases.

Rep Pract Oncol Radiother 2022 22;27(1):15-22. Epub 2022 Mar 22.

Department of Radiation Oncology, ASST Spedali Civili and Brescia University, Italy.

Brain metastases, the most common metastases in adults, will develop in up to 40% of cancer patients, accounting for more than one-half of all intracranial tumors. They are most associated with breast and lung cancer, melanoma and, less frequently, colorectal and kidney carcinoma. Magnetic resonance imaging (MRI) is the gold standard for diagnosis. Read More

View Article and Full-Text PDF

Robot-assisted partial nephrectomy for renal cell carcinoma in the isthmus of horseshoe kidney.

Urol Case Rep 2022 Jul 3;43:102076. Epub 2022 Apr 3.

Department of Urology, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

The anatomic features of a horseshoe kidney are unique-the kidney is fixed and poorly mobile, with many arterial and venous blood supplies, thereby complicating minimally invasive surgery for renal cancer in this setting. Several reports have described robot-assisted partial nephrectomy (RAPN) to treat renal cancer in a horseshoe kidney, but no reports of RAPN for renal cancer in the isthmus of a horseshoe kidney have been published to date. This case report describes the technique and usefulness of RAPN for treatment of renal cancer located in the isthmus of a horseshoe kidney. Read More

View Article and Full-Text PDF

Mucin-fused myeloid-derived growth factor (MYDGF164) exhibits a prolonged serum half-life and alleviates fibrosis in chronic kidney disease.

Br J Pharmacol 2022 Apr 7. Epub 2022 Apr 7.

School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.

Background And Purpose: Although no effective therapy is available to stop or reverse CKD progression targeting its key feature, the loss of peritubular capillaries (PTCs) leading to interstitial fibrosis, myeloid-derived growth factor (MYDGF) with tissue-repairing activities enlightens its therapeutic potential for CKD. However, the extremely short circulatory lifetime (15 min) restricts its application.

Experimental Approach: We selected a tandem repeated (TR) region of human CD164 as a carrier to fuse with MYDGF and then investigated for biophysical and pharmacokinetic changes. Read More

View Article and Full-Text PDF