3,259 results match your criteria Horseshoe Kidney


A Novel CNN-Based CAD System for Early Assessment of Transplanted Kidney Dysfunction.

Sci Rep 2019 Apr 11;9(1):5948. Epub 2019 Apr 11.

Bioengineering Department, University of Louisville, Louisville, KY, USA.

This paper introduces a deep-learning based computer-aided diagnostic (CAD) system for the early detection of acute renal transplant rejection. For noninvasive detection of kidney rejection at an early stage, the proposed CAD system is based on the fusion of both imaging markers and clinical biomarkers. The former are derived from diffusion-weighted magnetic resonance imaging (DW-MRI) by estimating the apparent diffusion coefficients (ADC) representing the perfusion of the blood and the diffusion of the water inside the transplanted kidney. Read More

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http://www.nature.com/articles/s41598-019-42431-3
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http://dx.doi.org/10.1038/s41598-019-42431-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459833PMC
April 2019
1 Read

Post therapy Wilms tumour or ectopic immature renal tissue: A pathologist's diagnostic dilemma.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):266-269

Department of Pathology, IPGME and R, Kolkata, West Bengal, India.

Post chemotherapy Wilms Tumour (PCWT) is a diagnostic conundrum both for the clinician and the pathologist, in view of its morphological similarity with ectopic immature renal tissue (EIRT). However, due to their varying prognoses and different lines of management, it is important to distinguish between the two. Here, we discuss clinical presentation and pathology of a case of PCWT, arising in a horse shoe deformity of the kidney in a 5 year old girl. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_112_18DOI Listing

Lump type crossed fused renal ectopia with bilateral vesicoureteral reflux: A case report.

World J Clin Cases 2019 Mar;7(6):773-777

Department of Urology, School of Medicine, Kyung Hee University, Seoul 05278, South Korea.

Background: Crossed fused renal ectopia is a rare congenital anomaly of the ascent of the kidney. This anomaly may be observed as a solitary kidney during initial evaluation. A solitary kidney must be evaluated for associated anomalies such as duplication, horseshoe kidney, or crossed renal ectopia. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i6.773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448078PMC
March 2019
1 Read

Diameters of Arteries Supplying Horseshoe Kidneys and the Level They Branch off Their Parental Vessels: A CT-Angiographic Study.

J Clin Med 2019 Apr 5;8(4). Epub 2019 Apr 5.

Department of Radiology, Barlicki University Hospital, Medical University of Łódź, Kopcińskiego Str. 22, 90-153 Łódź, Poland.

Background: The most common renal fusion anomaly is horseshoe kidney (HSK), a condition associated with variable arterial blood supply. The aim of this study was to determine whether the height of origin of the renal artery determines its diameter and whether it differs from the mean diameter of the renal arteries of normal kidneys (NK).

Methods: Computer tomography angiography (CTA) studies of 336 patients (88 HSK and 248 NK) were obtained in a search of renal arteries; these were than classified into four groups according to height of its origin: Group I, branching from the aorta superior to the inferior mesenteric artery (IMA); Group II, branching from the aorta below the IMA; Group III, branching from the iliac artery; and Group IV, originating from the internal and external iliac artery. Read More

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http://dx.doi.org/10.3390/jcm8040464DOI Listing
April 2019
1 Read

A Case of Sirenomelia: A Mermaid Baby.

J Obstet Gynaecol India 2019 Apr 17;69(Suppl 1):10-13. Epub 2018 Feb 17.

R-29, Khalatkar Hospital, Umred Road, Nagpur, 440009 India.

Introduction: Sirenomelia, also known as mermaid syndrome, is a very rare fatal congenital abnormality in which the legs are fused together, giving them the appearance of a mermaid's tail. It is commonly associated with abnormal kidney development, genital and rectal abnormalities. Only a handful of cases have been reported in other parts of the world and is very rare in India too. Read More

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http://dx.doi.org/10.1007/s13224-018-1099-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431711PMC
April 2019
1 Read

Crossed Fused Renal Ectopia with Single Ureter and Single Renal Vein: A Rare Case.

Cureus 2019 Jan 19;11(1):e3914. Epub 2019 Jan 19.

Radiology, Era's Lucknow Medical College and Hospital, Lucknow, IND.

Crossed fused renal ectopia with a single ureter and single renal vein is a rare congenital anomaly in which both the fused kidneys lie on one side of the body. We present an unusual case of crossed fused renal ectopia with a single ureter, single renal vein, and a calculus in a 22-year-old man who presented with lower abdominal pain, burning micturition, and a right-side abdominal lump present for three months. On abdominal ultrasound and non-contrast computed tomography (CT), the left kidney was not visualized in the left renal fossa. Read More

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http://dx.doi.org/10.7759/cureus.3914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426565PMC
January 2019
2 Reads

Establish new formulas for the calculation of renal and isthmus depth in horseshoe kidney.

Medicine (Baltimore) 2019 Mar;98(12):e14916

Department of Nuclear Medicine, Chinese PLA General Hospital, Beijing, China.

This study was performed to develop a new formula to estimate the renal and isthmus depth in horseshoe kidney, and to compare the new formula with previously published formulas.Renal depth, isthmus depth, vertebral thickness, and total thickness (T, cm) of the body at the level of the kidneys were measured by CT in 124 adults. Their sex, age, height (H, cm), and weight (W, kg) were recorded. Read More

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http://dx.doi.org/10.1097/MD.0000000000014916DOI Listing
March 2019
1 Read

Membrane-Associated, Not Cytoplasmic or Nuclear, FGFR1 Induces Neuronal Differentiation.

Cells 2019 Mar 14;8(3). Epub 2019 Mar 14.

Division of Neuroanatomy, Medical University of Innsbruck, 6020 Innsbruck, Austria.

The intracellular transport of receptor tyrosine kinases results in the differential activation of various signaling pathways. In this study, optogenetic stimulation of fibroblast growth factor receptor type 1 (FGFR1) was performed to study the effects of subcellular targeting of receptor kinases on signaling and neurite outgrowth. The catalytic domain of FGFR1 fused to the algal light-oxygen-voltage-sensing (LOV) domain was directed to different cellular compartments (plasma membrane, cytoplasm and nucleus) in human embryonic kidney (HEK293) and pheochromocytoma (PC12) cells. Read More

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https://www.mdpi.com/2073-4409/8/3/243
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http://dx.doi.org/10.3390/cells8030243DOI Listing
March 2019
3 Reads

The C-terminus of the gene product modulates transcription in a context-dependent manner.

Mol Vis 2019 23;25:165-173. Epub 2019 Feb 23.

Center for Molecular and Human Genetics, Nationwide Children's Research Institute, Columbus, OH.

Purpose: The evolutionarily conserved retinal homeobox (Rax) transcription factor is essential for normal eye development in all vertebrates. Despite Rax's biologic significance, the molecular mechanisms underlying Rax molecular function as a transcriptional regulator are poorly defined. The gene encodes a conserved octapeptide motif (OP) near the N-terminus and several conserved regions in the C-terminus of unknown function, including the orthopedia, aristaless, rax (OAR) domain and the RX domain. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386513PMC
February 2019
2 Reads

Ureteral Catheter Versus Nephrostomy Tube for Patients Undergoing Percutaneous Nephrolithotomy Under Spinal Anesthesia: A Prospectively Randomized Trial.

J Endourol 2019 Apr;33(4):291-294

1 Department of Urology, Konya Training and Research Hospital, Konya, Turkey.

Purpose: The aim of this study is to evaluate overnight ureteral catheterization vs nephrostomy tube for urinary diversion in patients undergoing percutaneous nephrolithotomy (PNL) under spinal anesthesia.

Materials And Methods: Patients were enrolled using block randomization between February 2016 and July 2016. Patients with renal stones >2 cm confirmed via noncontrast-enhanced CT were included. Read More

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https://www.liebertpub.com/doi/10.1089/end.2018.0875
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http://dx.doi.org/10.1089/end.2018.0875DOI Listing
April 2019
7 Reads

Low dose fluoroscopy during ureteroscopy does not compromise surgical outcomes.

J Endourol 2019 Feb 22. Epub 2019 Feb 22.

Hospital das Clínicas, University of Sao Paulo Medical School, Division of Urology , barata ribeiro street,490 room25 , São Paulo, São Paulo, Brazil , 01308001 ;

Objective: to evaluate if reducing the dose of fluoroscopy to ¼ of standard dose during unilateral ureteroscopy for ureteral stone treatment would impact in a reduction of total radiation emitted and if this strategy would impact in operation time, stone free rate and complication rate.

Methods: from August 2016 to August 2017, patients over 18 years old submitted to ureteroscopy for ureteral stone between 5-20 mm were prospectively randomized for ¼ dose reduction or standard dose fluoroscopy. Patients with abnormal urinary anatomy such as horseshoe kidney, pelvic kidney or duplex system were excluded from the study. Read More

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http://dx.doi.org/10.1089/end.2018.0722DOI Listing
February 2019
1 Read

Urinary proteome signature of Renal Cysts and Diabetes syndrome in children.

Sci Rep 2019 Feb 18;9(1):2225. Epub 2019 Feb 18.

Mosaiques Diagnostics GmbH, Hannover, Germany.

Renal Cysts and Diabetes Syndrome (RCAD) is an autosomal dominant disorder caused by mutations in the HNF1B gene encoding for the transcriptional factor hepatocyte nuclear factor-1B. RCAD is characterized as a multi-organ disease, with a broad spectrum of symptoms including kidney abnormalities (renal cysts, renal hypodysplasia, single kidney, horseshoe kidneys, hydronephrosis), early-onset diabetes mellitus, abnormal liver function, pancreatic hypoplasia and genital tract malformations. In the present study, using capillary electrophoresis coupled to mass spectrometry (CE-MS), we investigated the urinary proteome of a pediatric cohort of RCAD patients and different controls to identify peptide biomarkers and obtain further insights into the pathophysiology of this disorder. Read More

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http://dx.doi.org/10.1038/s41598-019-38713-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379363PMC
February 2019
1 Read
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Uncommon Polyoxygenated Sesquiterpenoids from South China Sea Soft Coral Lemnalia flava.

J Org Chem 2019 Mar 1;84(6):3083-3092. Epub 2019 Mar 1.

College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals , Zhejiang University of Technology , Hangzhou , China.

A detailed chemical investigation of the Chinese soft coral Lemnalia flava yielded four new nardosinane-type sesquiterpenoids (1-4), one new neolemnane-type sesquiterpenoid (5), and one new sesquiterpenoid with an uncommon 6/9 fused bicyclic skeleton (6), together with two known related compounds (7 and 8). The structures and absolute configurations of 1-8 were determined on the basis of extensive spectroscopic data analyses, X-ray diffraction analysis, chemical reactions, and computer-assisted structural elucidation including C NMR data calculation, residual dipolar coupling based NMR analysis, and time-dependent density functional theoryelectronic circular dichroism calculation. Plausible biogenetic pathways of two uncommon sesquiterpenoids (4 and 6) were proposed. Read More

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http://pubs.acs.org/doi/10.1021/acs.joc.8b02912
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http://dx.doi.org/10.1021/acs.joc.8b02912DOI Listing
March 2019
3 Reads

A Case of Supernumerary Kidney.

Cureus 2018 Dec 5;10(12):e3686. Epub 2018 Dec 5.

Radiology, Florida Hospital, Orlando, USA.

A supernumerary kidney is extremely rare, with less than 100 cases currently reported in the literature. When this variant is present, the additional renal parenchyma demonstrates its own collecting system, vascular supply, and distinct encapsulated parenchyma. Herein, we discuss the case of a supernumerary kidney in a 20-year-old male. Read More

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http://dx.doi.org/10.7759/cureus.3686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368426PMC
December 2018
2 Reads

EVAR Approach for Abdominal Aortic Aneurysm with Horseshoe Kidney: A Multicenter Experience.

Ann Vasc Surg 2019 Feb 4. Epub 2019 Feb 4.

New York University Langone Medical Center, New York, NY.

Background: Horseshoe kidney is a congenital abnormality, with an incidence of 0.25% of the total population. Only 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08905096193006
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http://dx.doi.org/10.1016/j.avsg.2018.10.042DOI Listing
February 2019
4 Reads

Exosome-Mediated miR-29 Transfer Reduces Muscle Atrophy and Kidney Fibrosis in Mice.

Mol Ther 2019 Mar 18;27(3):571-583. Epub 2019 Jan 18.

Department of Medicine, Renal Division, Emory University, Atlanta, GA 30322, USA. Electronic address:

Our previous study showed that miR-29 attenuates muscle wasting in chronic kidney disease. Other studies found that miR-29 has anti-fibrosis activity. We hypothesized that intramuscular injection of exosome-encapsulated miR-29 would counteract unilateral ureteral obstruction (UUO)-induced muscle wasting and renal fibrosis. Read More

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http://dx.doi.org/10.1016/j.ymthe.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403486PMC
March 2019
2 Reads

Cell-Penetrating Mx1 Enhances Anti-Viral Resistance against Mucosal Influenza Viral Infection.

Viruses 2019 Jan 28;11(2). Epub 2019 Jan 28.

Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.

Dynamin-like GTPase myxovirus resistance protein 1 (Mx1) is an intracellular anti-viral protein following the activation of type I and type III interferon signaling. Mx1 inhibits viral replication by blocking the transcription of viral RNA, and a deficiency in this protein enhances susceptibility to influenza infection. Thus, Mx1 could be another efficient target of anti-influenza therapy. Read More

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http://dx.doi.org/10.3390/v11020109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409533PMC
January 2019
2 Reads

Pelvic lipomatosis with ureteral calculi managed by flexible ureteroscopy: A case report.

Authors:
Lei Yang Wei Tang

Medicine (Baltimore) 2019 Jan;98(4):e14265

Urology Department, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Rationale: Pelvic lipomatosis (PL) is a benign disease characterized by overgrowth of adipose tissue in pelvic space. Hydronephrosis and ureterectasis are common complications caused by PL in urinary system. But PL accompanied with upper urinary tract calculi is rare. Read More

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http://dx.doi.org/10.1097/MD.0000000000014265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358402PMC
January 2019
20 Reads

Robot-assisted laparoscopic pyeloplasty (RALP) in children with horseshoe kidneys: results of a multicentric study.

World J Urol 2019 Jan 14. Epub 2019 Jan 14.

Division of Pediatric Urology, Federico II University of Naples, Via Pansini 5, 80131, Naples, Italy.

Purpose: This multicentric study aimed to report our experience with robot-assisted laparoscopic pyeloplasty (RALP) in children with horseshoe kidney (HSK).

Methods: The records of 14 patients (11 boys and 3 girls with an average age of 9 years), who underwent RALP for repair of pelvi-ureteric junction obstruction (PUJO) in HSK in five international pediatric urology units over a 5-year period, were retrospectively reviewed. A dismembered pyeloplasty with no division of isthmus was performed in all the cases. Read More

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http://dx.doi.org/10.1007/s00345-019-02632-xDOI Listing
January 2019
3 Reads

[High ureteral insertion as the cause of extreme hydronephrosis in a 5-year-old child with horseshoe kidney].

Dev Period Med 2018 ;22(4):371-375

Katedra i Klinika Pediatrii i Nefrologii, Warszawski Uniwersytet Medyczny, Polska.

The incidence of horseshoe kidney is 1 per 400-800 live births. From 44-52% of the patients with horseshoe kidney have other coexisting abnormalities of the urinary tract, such as hydronephrosis, vesicoureteral reflux and a duplex collecting system. Our patient, a 5-year old boy, was admitted to a pediatric nephrology department because of abdominal pain and vomiting. Read More

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January 2018
12 Reads

A Novel Nonsense Mutation of PHF6 in a Female with Extended Phenotypes of Borjeson-Forssman-Lehmann Syndrome.

J Clin Res Pediatr Endocrinol 2019 Jan 11. Epub 2019 Jan 11.

Department of Pediatric Endocrinology/Genetics, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute for Pediatric Research, Shanghai, China.

Borjeson-Forssman-Lehmann syndrome (BFLS) is a rare X-linked disease caused by PHF6 mutations. Classic BFLS is featured by intellectual disability (ID), developmental delay (DD), obesity, epilepsy, characteristic face and anomalies of fingers and toes. Endocrinological phenotypes and relevant outcome of treatment in this condition remains to be delineated. Read More

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http://dx.doi.org/10.4274/jcrpe.0220DOI Listing
January 2019
36 Reads

Dual-Tracer PET/CT Differentiates 2 Types of Primary Cancers and Metastases in a Patient With Crossed Fused Renal Ectopia.

Clin Nucl Med 2019 Feb;44(2):157-158

From the Department of Nuclear Medicine & PET and.

A patient was found incidentally on dual-tracer (C-acetate [ACT] and F-FDG [FDG]) PET/CT for having crossed fused renal ectopia and 2 types of malignant tumors, colonic carcinoma and renal cell carcinoma (RCC), each having its own characteristic tracer avidity. Multiple liver metastases were also mutually exclusive, with a purely ACT-avid group of metastatic lesions from RCC and another FDG-avid group from colonic carcinoma. Bone and lung metastases, however, could not be readily distinguishable in terms of primary origins. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002390DOI Listing
February 2019
3 Reads

Outcomes of kidney transplants in pediatric patients with the vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, limb abnormalities association.

Pediatr Transplant 2019 03 30;23(2):e13341. Epub 2018 Dec 30.

Division of Nephrology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

In this single-center retrospective study, we analyzed kidney transplant outcomes in nine pediatric patients with VACTERL [vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, limb abnormalities] association-making this the largest study of its kind. Of 743 pediatric kidney transplant recipients at our center (1980-2017), nine had documented diagnoses of VACTERL association. All nine had congenital anorectal malformations and renal anomalies, five had vertebral defects, and one had a bifid thumb and tracheoesophageal fistula. Read More

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http://dx.doi.org/10.1111/petr.13341DOI Listing
March 2019
7 Reads

Management and therapeutic options for abdominal aortic aneurysm coexistent with horseshoe kidney.

J Vasc Surg 2019 Apr 24;69(4):1257-1267. Epub 2018 Dec 24.

Department of Vascular Surgery, 401 General Military Hospital of Athens, Athens, Greece.

Background: Horseshoe kidney (HSK), referring to the abnormal fusion of the lower renal poles, represents one of the most common renal anomalies. One of its most significant features is the anomalous vasculature, with a number of accessory renal arteries originating from the aorta, the mesenteric arteries, and even the iliac arteries supplying both the renal kidneys and the renal isthmus.

Methods: A literature review was performed to identify and to present the most recent data regarding classification and imaging evaluation of HSK concomitant with abdominal aortic aneurysm (AAA). Read More

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http://dx.doi.org/10.1016/j.jvs.2018.10.009DOI Listing
April 2019
2 Reads

Pseudomyxoma extraperitonei in horseshoe kidney masquerading as renal hilar tumor: a case report.

Onco Targets Ther 2018 12;11:9027-9032. Epub 2018 Dec 12.

Department of Urology, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China,

Pseudomyxoma peritonei, a rare condition consisting of intraperitoneal mucinous tumors and ascites, most commonly arises from mucinous tumors of the appendix. Very rarely, mucinous deposits arise in the retroperitoneum without intraperitoneal involvement. This has been termed pseudomyxoma extraperitonei. Read More

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https://www.dovepress.com/pseudomyxoma-extraperitonei-in-hor
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http://dx.doi.org/10.2147/OTT.S184305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296204PMC
December 2018
13 Reads

Rhombencephalosynapsis: Fused cerebellum, confused geneticists.

Am J Med Genet C Semin Med Genet 2018 Dec;178(4):432-439

Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA.

Rhombencephalosynapsis (RES) is a unique cerebellar malformation characterized by fusion of the cerebellar hemispheres with partial or complete absence of a recognizable cerebellar vermis. Subsets of patients also have other brain malformations such as midbrain fusion with aqueductal stenosis, characteristic craniofacial features (prominent forehead, flat midface, hypertelorism, ear abnormalities), and somatic malformations (heart, kidney, spine, and limb defects). Similar to known genetic brain malformations, the RES cerebellar malformation is highly stereotyped, yet no genetic causes have been identified. Read More

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http://dx.doi.org/10.1002/ajmg.c.31666DOI Listing
December 2018
11 Reads

1000 consecutive ablation sessions in the era of computer assisted image guidance - Lessons learned.

Eur J Radiol Open 2019 5;6:1-8. Epub 2018 Dec 5.

Dept of Surgery and Urology, Danderyd University Hospital, Stockholm, Sweden.

Background: Ablation therapies for tumours are becoming more used as ablation modalities evolve and targeting solutions are getting better. There is an increasing body of long-term results challenging resection and proving lower morbidities and costs. The aim of this paper is to share the experiences from a high-volume centre in introducing computer assisted targeting solutions and efficient ablation modalities like microwave generators and irreversible electroporation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23520477183010
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http://dx.doi.org/10.1016/j.ejro.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282637PMC
December 2018
28 Reads

The Toldt fascia: A historic review and surgical implications in complete mesocolic excision for colon cancer.

Asian J Surg 2019 Jan 3;42(1):1-5. Epub 2018 Dec 3.

Division of Colorectal Surgery, Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

To clarify the anatomic concept of Toldt fascia, based on the literature review and the surgical anatomic dissection using laparoscopic or robotic approach. We undertook review of the historic literature and surgical videos from 250 patients with colorectal cancer operated on laparoscopically or robotically to discuss the surgical implications of Toldt fascia in complete mesocolic excision for colon cancer. Toldt fascia, sandwiched by the overlying mesothelial layer of the mesocolon and underlying mesothelial layer of the retroperitoneum, comprised loose fibrous tissues with minute vessels inside, and was contiguous from the ileocecal mesentery radix to the upper rectum. Read More

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http://dx.doi.org/10.1016/j.asjsur.2018.11.006DOI Listing
January 2019
7 Reads

Deployment of a Resuscitative Endovascular Balloon Occlusion of the Aorta Device in a Case of Gunshot Wound Injury to a Horseshoe Kidney.

Cureus 2018 Oct 2;10(10):e3399. Epub 2018 Oct 2.

Surgery, Texas Tech University Health Sciences Center, Lubbock, USA.

A horseshoe kidney (HSK) is a urological malformation that is typically found incidentally after a traumatic injury due to its asymptomatic nature. We present a 25-year-old male with multiorgan injuries secondary to blunt abdominal trauma caused by a gunshot wound. We report the courses of action taken that led to the identification of the HSK and other associated intra-abdominal injuries and the subsequent surgical management. Read More

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http://dx.doi.org/10.7759/cureus.3399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279008PMC
October 2018
2 Reads

A fetal case of microphthalmia and limb anomalies with abnormal neuronal migration associated with SMOC1 biallelic variants.

Eur J Med Genet 2018 Nov 13. Epub 2018 Nov 13.

University of Torino, Department of Medical Sciences, 10126, Torino, Italy.

Microphthalmia with limb anomalies (MLA, OMIM, 206920) is a rare autosomal-recessive disease caused by biallelic pathogenic variants in the SMOC1 gene. It is characterized by ocular disorders (microphtalmia or anophtalmia) and limb anomalies (oligodactyly, syndactyly, and synostosis of the 4th and 5th metacarpals), variably associated with long bone hypoplasia, horseshoe kidney, venous anomalies, vertebral anomalies, developmental delay, and intellectual disability. Here, we report the case of a woman who interrupted her pregnancy after ultrasound scans revealed a depression of the frontal bone, posterior fossa anomalies, cerebral ventricular enlargement, cleft spine involving the sacral and lower-lumbar vertebrae, and bilateral microphthalmia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697212183039
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http://dx.doi.org/10.1016/j.ejmg.2018.11.012DOI Listing
November 2018
17 Reads

The Anatomic Structure of a Fused Renal Pyramid and Its Clinical Significance in the Establishment of Percutaneous Renal Access.

Urology 2019 Feb 14;124:38-45. Epub 2018 Nov 14.

Department of Urology, Robert Debré Teaching Hospital, University of Reims, Reims, France.

Objective: To explore the clinical significance of the fused renal pyramid (FRP) in establishing percutaneous renal access, and the anatomic basis for avoiding vascular injury caused by puncturing through this renal pyramid with the aim of achieving accurate puncture in percutaneous nephrolithotomy.

Materials And Methods: Sixty-two cadaveric kidneys and 105 porcine kidneys were selected for the assessment of regional anatomy, to explore the anatomic structure of the FRP and determine its frequency. Then, we compared the effects of 4 different puncture paths on the occurrence of renal vascular injury when respectively punctured through the normal renal pyramid (group A), the centerline of one side pyramid of the FRP (group B), the center of the entire FRP (group C) and the renal column (group D). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00904295183114
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http://dx.doi.org/10.1016/j.urology.2018.11.004DOI Listing
February 2019
16 Reads

TRUS-guided drainage of the ectopic ureter entering the prostatic urethra and TRUS-guided transurethral neo-orifice formation using holmium laser.

J Ultrason 2018 ;18(74):255-264

Department of General and Transplant Surgery and Nutritional Treatment, Medical University of Lublin, Poland.

A fifty-nine year-old male was hospitalized for exacerbation of chronic pancreatitis. As a gigantic cyst of the pancreatic tail was identified, it was fused with the jejunal loop. Due to persistent fever and severe symptoms in the storage and voiding phases, the patient was referred to a urologist. Read More

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http://dx.doi.org/10.15557/JoU.2018.0037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442213PMC
January 2018
9 Reads

Exercise training remodels human skeletal muscle mitochondrial fission and fusion machinery towards a pro-elongation phenotype.

Acta Physiol (Oxf) 2019 Apr 1;225(4):e13216. Epub 2018 Dec 1.

Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.

Aims: Mitochondria exist as a morphologically plastic network driven by cellular bioenergetic demand. Induction of fusion and fission machinery allows the organelle to regulate quality control and substrate flux. Physiological stressors promote fragmentation of the mitochondrial network, a process implicated in the onset of metabolic disease, including type 2 diabetes and obesity. Read More

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http://doi.wiley.com/10.1111/apha.13216
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http://dx.doi.org/10.1111/apha.13216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416060PMC
April 2019
9 Reads

Secondary hypertension in patients with saccular intracranial aneurysm disease: A population based study.

PLoS One 2018 31;13(10):e0206432. Epub 2018 Oct 31.

Neurosurgery of NeuroCenter, Kuopio University Hospital, and Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

Background: Secondary hypertension is a serious form of hypertension, involving 5% to 10% of all hypertension patients. Hypertension is a risk factor of the saccular intracranial aneurysm (sIA) disease and subarachnoid hemorrhage from ruptured sIA (aSAH), but the impact of secondary hypertension on sIA disease is poorly known. In a defined Eastern Finnish sIA population we studied the prevalence of secondary hypertension and its impact on sIA disease phenotype. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206432PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209332PMC
April 2019
6 Reads

[Design and synthesis of imidazo-fused heterocycles derivatives and their anti-tumor activity against breast cancer in mice].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Aug;38(9):1052-1060

Clinical Research Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510315, China.

Objective: To synthesize compounds based on imidazo-fused heterocycles and evaluate their anti-tumor activity against breast cancer.

Methods: The compounds 1a-1e, 2a and 2b were synthesized by aerobic copper-catalyzed halocyclization of methyl N-heteroaromatics with aliphatic amines; 3a and 3b were generated by sonogashira reaction and Suzuki reaction, respectively; the compounds 4a-4c were obtained by Buchwald-Hartwig reaction of the corresponding amines and 1e. The effects of these compounds against breast cancer cells and their nephrotoxicity were determined using MTT assay. Read More

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http://www.j-smu.com/oa/darticle.aspx?type=view&id=20180
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http://dx.doi.org/10.12122/j.issn.1673-4254.2018.09.05DOI Listing
August 2018
4 Reads

Present indications and techniques of percutaneous nephrolithotomy: What the future holds?

Asian J Urol 2018 Oct 6;5(4):287-294. Epub 2018 Sep 6.

Department of Urology, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem, Israel.

The purpose of the review was to present the latest updates on percutaneous nephrolithotomy (PCNL) procedure in terms of indications and evolving techniques, and to identify the advantages and disadvantages of each modality. The data for this review were collected after a thorough PubMed search in core clinical journals in English language. The key words included "PCNL" and "PNL" in combination with "indications", "techniques", "review" and "miniaturized PCNL". Read More

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https://www.journals.elsevier.com/asian-journal-of-urology/r
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https://www.sciencedirect.com/journal/asian-journal-of-urolo
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https://linkinghub.elsevier.com/retrieve/pii/S22143882183006
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http://dx.doi.org/10.1016/j.ajur.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197369PMC
October 2018
19 Reads

Safety and efficacy of PNL vs RIRS in the management of stones located in horseshoe kidneys: A critical comparative evaluation.

Arch Ital Urol Androl 2018 Sep 30;90(3):149-154. Epub 2018 Sep 30.

Health Sciences University, Dr. Lütfi Kirdar Training and Research Hospital, Urology Clinic, Istanbul.

Aim: To assess the efficacy and safety of two different techniques (Percutaneous nephrolithotomy (PNL) vs Retrograde intrarenal surgery (RIRS)) in the management of stones in patients with horseshoe kidneys (HSK).

Patients And Methods: Departmental files of 88 cases with radiopaque kidney stones in horseshoe kidneys undergoing two different approaches (PNL vs RIRS) were evaluated with respect to the success and complication rates of in a retrospective manner. In addition to the factors related with the procedures (success and complication rates, additional procedures), patient and stone characteristics were all well evaluated. Read More

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http://dx.doi.org/10.4081/aiua.2018.3.149DOI Listing
September 2018
3 Reads

Pancake kidney, a rare and often misdiagnosed malformation: a case report and radiological differential diagnosis.

J Ultrasound 2018 Oct 25. Epub 2018 Oct 25.

Department of Diagnostic and Interventional Radiology and Neuroradiology of IRCCS, San Matteo University Hospital Foundation, Pavia, Italy.

Renal ectopia and fusion anomalies are Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT) that are usually incidentally detected and asymptomatic. Patients affected present a higher risk of complications like recurrent urinary tract infections or obstruction. Pancake kidney (PK) is one of the rarest types of renal anomaly with complete fusion of the superior, mild and inferior poles of both kidneys in the pelvic cavity. Read More

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http://link.springer.com/10.1007/s40477-018-0331-4
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http://dx.doi.org/10.1007/s40477-018-0331-4DOI Listing
October 2018
12 Reads

Five New Cases of Primary Renal Carcinoid Tumor: Case Reports and Literature Review.

Pathol Oncol Res 2018 Oct 25. Epub 2018 Oct 25.

Department of Urology, University of Minnesota Medical School, 420 Delaware St. SE MMC 394, Minneapolis, MN, 55455, USA.

Carcinoid tumors, a slow-growing NET, most commonly arise in the gastrointestinal tract (73.7%), followed by the bronchopulmonary system (25.1%), and least commonly in the genitourinary system (<1%). Read More

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http://link.springer.com/10.1007/s12253-018-0481-x
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http://dx.doi.org/10.1007/s12253-018-0481-xDOI Listing
October 2018
17 Reads

A Case of Renal Pelvic Cancer Complicated by Horseshoe Kidney Treated with RoboSurgeon Gasless Single-Port Retroperitoneoscopic Nephroureterectomy.

Case Rep Urol 2018 18;2018:3231480. Epub 2018 Sep 18.

Department of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Japan.

A 78-year-old man who had a horseshoe kidney (HSK) visited us because of gross hematuria and suspicious urine cytology. CT and MRI revealed a right renal pelvic tumor of 28 mm in diameter. He underwent gasless single-port retroperitoneoscopic nephroureterectomy with division of the isthmus via the right pararectal small incision using the RoboSurgeon system. Read More

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http://dx.doi.org/10.1155/2018/3231480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167582PMC
September 2018
4 Reads

Visualization of a Dinoflagellate-Infecting Virus HcDNAV and Its Infection Process.

Viruses 2018 10 11;10(10). Epub 2018 Oct 11.

Faculty of Science and Technology, Kochi University, Nankoku 783-8502, Kochi, Japan.

HcDNAV (a type species of Genus ) is a large double-stranded DNA virus, which lytically infects the bloom-forming marine microalga Horiguchi (Dinophyceae). In the present study, detailed observation of the HcDNAV particle and its infection process was conducted via field emission scanning electron microscopy (FE-SEM) and epifluorescence microscopy (EFM). Each five-fold vertex of the icosahedral virion was decorated with a protrusion, which may be related to the entry process of HcDNAV into the host. Read More

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http://www.mdpi.com/1999-4915/10/10/554
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http://dx.doi.org/10.3390/v10100554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212932PMC
October 2018
9 Reads

Liver atoll sign: Nodular regenerative hyperplasia.

J Med Imaging Radiat Oncol 2018 Oct;62 Suppl 1:84

Department of Radiology, Concord Repatriation General Hospital, Concord, New South Wales, Australia.

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http://doi.wiley.com/10.1111/1754-9485.32_12784
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http://dx.doi.org/10.1111/1754-9485.32_12784DOI Listing
October 2018
7 Reads

Characterization of grass carp (Ctenopharyngodon idella) beta-defensin 1: implications for its role in inflammation control.

Biosci Biotechnol Biochem 2018 Oct 8:1-8. Epub 2018 Oct 8.

b Department of Laboratory Medicine , Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital , Chengdu , People's Republic of China.

Considering that fish grows in a complex aquatic environment, there is an increasing interest in fish β-defensins, which is an important group of antimicrobial peptides (AMPs). In this study, grass carp (Ctenopharyngodon idella) β-defensin 1 (gcdefb1) was isolated using homology cloning technology. Tissue distribution assay showed that gcdefb1 transcripts were expressed with the highest levels in brain and liver, followed by some mucous tissues. Read More

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https://www.tandfonline.com/doi/full/10.1080/09168451.2018.1
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http://dx.doi.org/10.1080/09168451.2018.1519386DOI Listing
October 2018
21 Reads

Changing trends in the endourological management of urolithiasis in anomalous kidneys.

BJU Int 2019 Feb 2;123(2):318-327. Epub 2018 Nov 2.

Department of Urology, Muljibhai Patel Urological Hospital, Nadiad, Gujarat, India.

Objectives: To present our single-centre experience of urolithiasis management in anomalous kidneys, highlighting the need for an algorithm-based approach in deciding the appropriate treatment method for each type.

Patients And Methods: We retrospectively reviewed the data of all the patients who presented to our renal unit with urolithiasis in an anomalous kidney between January 1990 and July 2014. The peri-operative characteristics of all the patients, along with management approach, were studied. Read More

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http://doi.wiley.com/10.1111/bju.14575
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http://dx.doi.org/10.1111/bju.14575DOI Listing
February 2019
10 Reads

Open repair of ruptured abdominal aortic aneurysm with associated horseshoe kidney.

Int Angiol 2018 Dec 24;37(6):471-478. Epub 2018 Sep 24.

Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Background: Ruptured abdominal aortic aneurysms (RAAA) with concomitant horseshoe kidney (HK) present a unique challenge at the time of repair. The aim of this article was to propose the most rationale strategy during open repair (OR) of RAAA in the presence of HK.

Methods: We identified and analyzed all patients treated at the clinic due to RAAA and HK. Read More

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http://dx.doi.org/10.23736/S0392-9590.18.04039-7DOI Listing
December 2018
3 Reads

Defective Vagal Innervation in Murine Mutant Hearts.

J Cardiovasc Dev Dis 2018 Sep 23;5(4). Epub 2018 Sep 23.

UCL Great Ormond Street-Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

Haploinsufficiency of the T-box transcription factor is responsible for many features of 22q11.2 deletion syndrome. is expressed dynamically in the pharyngeal apparatus during mouse development and homozygous mutants display numerous severe defects including abnormal cranial ganglion formation and neural crest cell defects. Read More

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http://dx.doi.org/10.3390/jcdd5040049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306933PMC
September 2018
14 Reads

Identification of hepatotoxicity and renal dysfunction of pyrene in adult male rats.

Environ Toxicol 2018 Dec 21;33(12):1304-1311. Epub 2018 Sep 21.

Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Zhejiang, People's Republic of China.

Polycyclic aromatic hydrocarbons (PAHs) are a group of persistent organic pollutants primarily formed from the incomplete combustion of carbonaceous materials, and have adverse effects on human health. In this study, we investigated whether pyrene, a PAH consisting of 4 fused benzene rings, has adverse effects on rat. Adult male Sprague-Dawly rats were treated daily by oral gavage with vehicle (corn oil) or pyrene at doses of 375, 750, 1500, or 2200 mg/kg/day for 4 days. Read More

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http://dx.doi.org/10.1002/tox.22638DOI Listing
December 2018
23 Reads

The complete genomic sequence of Rhinolophus gammaherpesvirus 1 isolated from a greater horseshoe bat.

Arch Virol 2019 Jan 19;164(1):317-319. Epub 2018 Sep 19.

Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8515, Japan.

In a comprehensive research project on bat viruses, we successfully isolated a novel herpesvirus from the spleen of a greater horseshoe bat (Rhinolophus ferrumequinum) in Japan using a cell line established from the kidney of the same bat. This herpesvirus was a novel gammaherpesvirus (Rhinolophus gammaherpesvirus 1; RGHV-1), which belonged to the genus Percavirus. The whole RGHV-1 genome (147,790 bp) showed that 12 of the 84 genes predicted to contain open reading frames did not show any homology to those of other herpesviruses. Read More

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http://dx.doi.org/10.1007/s00705-018-4040-2DOI Listing
January 2019
3 Reads

Head-to-Head Comparison of Modified Laparoscopic Pyeloplasty and Robot-Assisted Pyeloplasty for Ureteropelvic Junction Obstruction in China.

Urol Int 2018 19;101(3):337-344. Epub 2018 Sep 19.

Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China.

Objective: To compare the outcomes of modified laparoscopic pyeloplasty (LP) and robot-assisted pyeloplasty (RLP) for ureteropelvic junction obstruction (UPJO) in China patients.

Materials And Methods: We retrospectively reviewed the medical records of patients who underwent modified LP and RLP using a transperitoneal laparoscopic approach at 2 different medical institutions between October 2009 and November 2017.

Results: Seventy-six patients underwent modified LP and 140 patients underwent RLP. Read More

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http://dx.doi.org/10.1159/000492337DOI Listing
April 2019
14 Reads
1.150 Impact Factor