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Sci Rep 2019 Feb 18;9(1):2225. Epub 2019 Feb 18.

Mosaiques Diagnostics GmbH, Hannover, Germany.

Renal Cysts and Diabetes Syndrome (RCAD) is an autosomal dominant disorder caused by mutations in the HNF1B gene encoding for the transcriptional factor hepatocyte nuclear factor-1B. RCAD is characterized as a multi-organ disease, with a broad spectrum of symptoms including kidney abnormalities (renal cysts, renal hypodysplasia, single kidney, horseshoe kidneys, hydronephrosis), early-onset diabetes mellitus, abnormal liver function, pancreatic hypoplasia and genital tract malformations. In the present study, using capillary electrophoresis coupled to mass spectrometry (CE-MS), we investigated the urinary proteome of a pediatric cohort of RCAD patients and different controls to identify peptide biomarkers and obtain further insights into the pathophysiology of this disorder. Read More

Cureus 2018 Dec 5;10(12):e3686. Epub 2018 Dec 5.

Radiology, Florida Hospital, Orlando, USA.

A supernumerary kidney is extremely rare, with less than 100 cases currently reported in the literature. When this variant is present, the additional renal parenchyma demonstrates its own collecting system, vascular supply, and distinct encapsulated parenchyma. Herein, we discuss the case of a supernumerary kidney in a 20-year-old male. Read More

Ann Vasc Surg 2019 Feb 4. Epub 2019 Feb 4.

New York University Langone Medical Center, 530 First Ave, Ste 6F, New York, NY 10016. United States.

Introduction: Horseshoe kidney is a congenital abnormality, with an incidence of 0.25% of the total population. Only 0. Read More

Mol Ther 2019 Jan 18. Epub 2019 Jan 18.

Department of Medicine, Renal Division, Emory University, Atlanta, GA 30322, USA. Electronic address:

Our previous study showed that miR-29 attenuates muscle wasting in chronic kidney disease. Other studies found that miR-29 has anti-fibrosis activity. We hypothesized that intramuscular injection of exosome-encapsulated miR-29 would counteract unilateral ureteral obstruction (UUO)-induced muscle wasting and renal fibrosis. Read More

Viruses 2019 Jan 28;11(2). Epub 2019 Jan 28.

Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.

Dynamin-like GTPase myxovirus resistance protein 1 (Mx1) is an intracellular anti-viral protein following the activation of type I and type III interferon signaling. Mx1 inhibits viral replication by blocking the transcription of viral RNA, and a deficiency in this protein enhances susceptibility to influenza infection. Thus, Mx1 could be another efficient target of anti-influenza therapy. Read More

Medicine (Baltimore) 2019 Jan;98(4):e14265

Urology Department, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Rationale: Pelvic lipomatosis (PL) is a benign disease characterized by overgrowth of adipose tissue in pelvic space. Hydronephrosis and ureterectasis are common complications caused by PL in urinary system. But PL accompanied with upper urinary tract calculi is rare. Read More

World J Urol 2019 Jan 14. Epub 2019 Jan 14.

Division of Pediatric Urology, Federico II University of Naples, Via Pansini 5, 80131, Naples, Italy.

Purpose: This multicentric study aimed to report our experience with robot-assisted laparoscopic pyeloplasty (RALP) in children with horseshoe kidney (HSK).

Methods: The records of 14 patients (11 boys and 3 girls with an average age of 9 years), who underwent RALP for repair of pelvi-ureteric junction obstruction (PUJO) in HSK in five international pediatric urology units over a 5-year period, were retrospectively reviewed. A dismembered pyeloplasty with no division of isthmus was performed in all the cases. Read More

Dev Period Med 2018 ;22(4):371-375

Katedra i Klinika Pediatrii i Nefrologii, Warszawski Uniwersytet Medyczny, Polska.

The incidence of horseshoe kidney is 1 per 400-800 live births. From 44-52% of the patients with horseshoe kidney have other coexisting abnormalities of the urinary tract, such as hydronephrosis, vesicoureteral reflux and a duplex collecting system. Our patient, a 5-year old boy, was admitted to a pediatric nephrology department because of abdominal pain and vomiting. Read More

J Clin Res Pediatr Endocrinol 2019 Jan 11. Epub 2019 Jan 11.

Department of Pediatric Endocrinology/Genetics, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute for Pediatric Research, Shanghai, China.

Borjeson-Forssman-Lehmann syndrome (BFLS) is a rare X-linked disease caused by PHF6 mutations. Classic BFLS is featured by intellectual disability (ID), developmental delay (DD), obesity, epilepsy, characteristic face and anomalies of fingers and toes. Endocrinological phenotypes and relevant outcome of treatment in this condition remains to be delineated. Read More

Pediatr Transplant 2019 Mar 30;23(2):e13341. Epub 2018 Dec 30.

Division of Nephrology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

In this single-center retrospective study, we analyzed kidney transplant outcomes in nine pediatric patients with VACTERL [vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, limb abnormalities] association-making this the largest study of its kind. Of 743 pediatric kidney transplant recipients at our center (1980-2017), nine had documented diagnoses of VACTERL association. All nine had congenital anorectal malformations and renal anomalies, five had vertebral defects, and one had a bifid thumb and tracheoesophageal fistula. Read More

J Vasc Surg 2018 Dec 24. Epub 2018 Dec 24.

Department of Vascular Surgery, 401 General Military Hospital of Athens, Athens, Greece.

Background: Horseshoe kidney (HSK), referring to the abnormal fusion of the lower renal poles, represents one of the most common renal anomalies. One of its most significant features is the anomalous vasculature, with a number of accessory renal arteries originating from the aorta, the mesenteric arteries, and even the iliac arteries supplying both the renal kidneys and the renal isthmus.

Methods: A literature review was performed to identify and to present the most recent data regarding classification and imaging evaluation of HSK concomitant with abdominal aortic aneurysm (AAA). Read More

Onco Targets Ther 2018 12;11:9027-9032. Epub 2018 Dec 12.

Department of Urology, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China,

Pseudomyxoma peritonei, a rare condition consisting of intraperitoneal mucinous tumors and ascites, most commonly arises from mucinous tumors of the appendix. Very rarely, mucinous deposits arise in the retroperitoneum without intraperitoneal involvement. This has been termed pseudomyxoma extraperitonei. Read More

Am J Med Genet C Semin Med Genet 2018 Dec;178(4):432-439

Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA.

Rhombencephalosynapsis (RES) is a unique cerebellar malformation characterized by fusion of the cerebellar hemispheres with partial or complete absence of a recognizable cerebellar vermis. Subsets of patients also have other brain malformations such as midbrain fusion with aqueductal stenosis, characteristic craniofacial features (prominent forehead, flat midface, hypertelorism, ear abnormalities), and somatic malformations (heart, kidney, spine, and limb defects). Similar to known genetic brain malformations, the RES cerebellar malformation is highly stereotyped, yet no genetic causes have been identified. Read More

Eur J Radiol Open 2019 5;6:1-8. Epub 2018 Dec 5.

Dept of Surgery and Urology, Danderyd University Hospital, Stockholm, Sweden.

Background: Ablation therapies for tumours are becoming more used as ablation modalities evolve and targeting solutions are getting better. There is an increasing body of long-term results challenging resection and proving lower morbidities and costs. The aim of this paper is to share the experiences from a high-volume centre in introducing computer assisted targeting solutions and efficient ablation modalities like microwave generators and irreversible electroporation. Read More

Asian J Surg 2019 Jan 3;42(1):1-5. Epub 2018 Dec 3.

Division of Colorectal Surgery, Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

To clarify the anatomic concept of Toldt fascia, based on the literature review and the surgical anatomic dissection using laparoscopic or robotic approach. We undertook review of the historic literature and surgical videos from 250 patients with colorectal cancer operated on laparoscopically or robotically to discuss the surgical implications of Toldt fascia in complete mesocolic excision for colon cancer. Toldt fascia, sandwiched by the overlying mesothelial layer of the mesocolon and underlying mesothelial layer of the retroperitoneum, comprised loose fibrous tissues with minute vessels inside, and was contiguous from the ileocecal mesentery radix to the upper rectum. Read More

Cureus 2018 Oct 2;10(10):e3399. Epub 2018 Oct 2.

Surgery, Texas Tech University Health Sciences Center, Lubbock, USA.

A horseshoe kidney (HSK) is a urological malformation that is typically found incidentally after a traumatic injury due to its asymptomatic nature. We present a 25-year-old male with multiorgan injuries secondary to blunt abdominal trauma caused by a gunshot wound. We report the courses of action taken that led to the identification of the HSK and other associated intra-abdominal injuries and the subsequent surgical management. Read More

Eur J Med Genet 2018 Nov 13. Epub 2018 Nov 13.

University of Torino, Department of Medical Sciences, 10126, Torino, Italy.

Microphthalmia with limb anomalies (MLA, OMIM, 206920) is a rare autosomal-recessive disease caused by biallelic pathogenic variants in the SMOC1 gene. It is characterized by ocular disorders (microphtalmia or anophtalmia) and limb anomalies (oligodactyly, syndactyly, and synostosis of the 4th and 5th metacarpals), variably associated with long bone hypoplasia, horseshoe kidney, venous anomalies, vertebral anomalies, developmental delay, and intellectual disability. Here, we report the case of a woman who interrupted her pregnancy after ultrasound scans revealed a depression of the frontal bone, posterior fossa anomalies, cerebral ventricular enlargement, cleft spine involving the sacral and lower-lumbar vertebrae, and bilateral microphthalmia. Read More

Urology 2019 Feb 14;124:38-45. Epub 2018 Nov 14.

Department of Urology, Robert Debré Teaching Hospital, University of Reims, Reims, France.

Objective: To explore the clinical significance of the fused renal pyramid (FRP) in establishing percutaneous renal access, and the anatomic basis for avoiding vascular injury caused by puncturing through this renal pyramid with the aim of achieving accurate puncture in percutaneous nephrolithotomy.

Materials And Methods: Sixty-two cadaveric kidneys and 105 porcine kidneys were selected for the assessment of regional anatomy, to explore the anatomic structure of the FRP and determine its frequency. Then, we compared the effects of 4 different puncture paths on the occurrence of renal vascular injury when respectively punctured through the normal renal pyramid (group A), the centerline of one side pyramid of the FRP (group B), the center of the entire FRP (group C) and the renal column (group D). Read More

J Ultrason 2018 ;18(74):255-264

Department of General and Transplant Surgery and Nutritional Treatment, Medical University of Lublin, Poland.

A fifty-nine year-old male was hospitalized for exacerbation of chronic pancreatitis. As a gigantic cyst of the pancreatic tail was identified, it was fused with the jejunal loop. Due to persistent fever and severe symptoms in the storage and voiding phases, the patient was referred to a urologist. Read More

Acta Physiol (Oxf) 2018 Nov 8:e13216. Epub 2018 Nov 8.

Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.

Aims: Mitochondria exist as a morphologically plastic network driven by cellular bioenergetic demand. Induction of fusion and fission machinery allows the organelle to regulate quality control and substrate flux. Physiological stressors promote fragmentation of the mitochondrial network, a process implicated in the onset of metabolic disease, including type 2 diabetes and obesity. Read More

PLoS One 2018 31;13(10):e0206432. Epub 2018 Oct 31.

Neurosurgery of NeuroCenter, Kuopio University Hospital, and Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

Background: Secondary hypertension is a serious form of hypertension, involving 5% to 10% of all hypertension patients. Hypertension is a risk factor of the saccular intracranial aneurysm (sIA) disease and subarachnoid hemorrhage from ruptured sIA (aSAH), but the impact of secondary hypertension on sIA disease is poorly known. In a defined Eastern Finnish sIA population we studied the prevalence of secondary hypertension and its impact on sIA disease phenotype. Read More

Asian J Urol 2018 Oct 6;5(4):287-294. Epub 2018 Sep 6.

Department of Urology, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem, Israel.

The purpose of the review was to present the latest updates on percutaneous nephrolithotomy (PCNL) procedure in terms of indications and evolving techniques, and to identify the advantages and disadvantages of each modality. The data for this review were collected after a thorough PubMed search in core clinical journals in English language. The key words included "PCNL" and "PNL" in combination with "indications", "techniques", "review" and "miniaturized PCNL". Read More

Arch Ital Urol Androl 2018 Sep 30;90(3):149-154. Epub 2018 Sep 30.

Health Sciences University, Dr. Lütfi Kirdar Training and Research Hospital, Urology Clinic, Istanbul.

Aim: To assess the efficacy and safety of two different techniques (Percutaneous nephrolithotomy (PNL) vs Retrograde intrarenal surgery (RIRS)) in the management of stones in patients with horseshoe kidneys (HSK).

Patients And Methods: Departmental files of 88 cases with radiopaque kidney stones in horseshoe kidneys undergoing two different approaches (PNL vs RIRS) were evaluated with respect to the success and complication rates of in a retrospective manner. In addition to the factors related with the procedures (success and complication rates, additional procedures), patient and stone characteristics were all well evaluated. Read More

J Ultrasound 2018 Oct 25. Epub 2018 Oct 25.

Department of Diagnostic and Interventional Radiology and Neuroradiology of IRCCS, San Matteo University Hospital Foundation, Pavia, Italy.

Renal ectopia and fusion anomalies are Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT) that are usually incidentally detected and asymptomatic. Patients affected present a higher risk of complications like recurrent urinary tract infections or obstruction. Pancake kidney (PK) is one of the rarest types of renal anomaly with complete fusion of the superior, mild and inferior poles of both kidneys in the pelvic cavity. Read More

Pathol Oncol Res 2018 Oct 25. Epub 2018 Oct 25.

Department of Urology, University of Minnesota Medical School, 420 Delaware St. SE MMC 394, Minneapolis, MN, 55455, USA.

Carcinoid tumors, a slow-growing NET, most commonly arise in the gastrointestinal tract (73.7%), followed by the bronchopulmonary system (25.1%), and least commonly in the genitourinary system (<1%). Read More

Case Rep Urol 2018 18;2018:3231480. Epub 2018 Sep 18.

Department of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Japan.

A 78-year-old man who had a horseshoe kidney (HSK) visited us because of gross hematuria and suspicious urine cytology. CT and MRI revealed a right renal pelvic tumor of 28 mm in diameter. He underwent gasless single-port retroperitoneoscopic nephroureterectomy with division of the isthmus via the right pararectal small incision using the RoboSurgeon system. Read More

Viruses 2018 10 11;10(10). Epub 2018 Oct 11.

Faculty of Science and Technology, Kochi University, Nankoku 783-8502, Kochi, Japan.

HcDNAV (a type species of Genus ) is a large double-stranded DNA virus, which lytically infects the bloom-forming marine microalga Horiguchi (Dinophyceae). In the present study, detailed observation of the HcDNAV particle and its infection process was conducted via field emission scanning electron microscopy (FE-SEM) and epifluorescence microscopy (EFM). Each five-fold vertex of the icosahedral virion was decorated with a protrusion, which may be related to the entry process of HcDNAV into the host. Read More

J Med Imaging Radiat Oncol 2018 Oct;62 Suppl 1:84

Department of Radiology, Concord Repatriation General Hospital, Concord, New South Wales, Australia.

Biosci Biotechnol Biochem 2018 Oct 8:1-8. Epub 2018 Oct 8.

b Department of Laboratory Medicine , Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital , Chengdu , People's Republic of China.

Considering that fish grows in a complex aquatic environment, there is an increasing interest in fish β-defensins, which is an important group of antimicrobial peptides (AMPs). In this study, grass carp (Ctenopharyngodon idella) β-defensin 1 (gcdefb1) was isolated using homology cloning technology. Tissue distribution assay showed that gcdefb1 transcripts were expressed with the highest levels in brain and liver, followed by some mucous tissues. Read More

Urol Case Rep 2018 Nov 22;21:119-121. Epub 2018 Sep 22.

Dept of Urology, Botucatu School of Medicina, Univ. Estadual Paulista, UNESP, Botucatu, Brazil.

BJU Int 2019 Feb 2;123(2):318-327. Epub 2018 Nov 2.

Department of Urology, Muljibhai Patel Urological Hospital, Nadiad, Gujarat, India.

Objectives: To present our single-centre experience of urolithiasis management in anomalous kidneys, highlighting the need for an algorithm-based approach in deciding the appropriate treatment method for each type.

Patients And Methods: We retrospectively reviewed the data of all the patients who presented to our renal unit with urolithiasis in an anomalous kidney between January 1990 and July 2014. The peri-operative characteristics of all the patients, along with management approach, were studied. Read More

Int Angiol 2018 Dec 24;37(6):471-478. Epub 2018 Sep 24.

Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Background: Ruptured abdominal aortic aneurysms (RAAA) with concomitant horseshoe kidney (HK) present a unique challenge at the time of repair. The aim of this article was to propose the most rationale strategy during open repair (OR) of RAAA in the presence of HK.

Methods: We identified and analyzed all patients treated at the clinic due to RAAA and HK. Read More

J Cardiovasc Dev Dis 2018 Sep 23;5(4). Epub 2018 Sep 23.

UCL Great Ormond Street-Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

Haploinsufficiency of the T-box transcription factor is responsible for many features of 22q11.2 deletion syndrome. is expressed dynamically in the pharyngeal apparatus during mouse development and homozygous mutants display numerous severe defects including abnormal cranial ganglion formation and neural crest cell defects. Read More

Environ Toxicol 2018 Dec 21;33(12):1304-1311. Epub 2018 Sep 21.

Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Zhejiang, People's Republic of China.

Polycyclic aromatic hydrocarbons (PAHs) are a group of persistent organic pollutants primarily formed from the incomplete combustion of carbonaceous materials, and have adverse effects on human health. In this study, we investigated whether pyrene, a PAH consisting of 4 fused benzene rings, has adverse effects on rat. Adult male Sprague-Dawly rats were treated daily by oral gavage with vehicle (corn oil) or pyrene at doses of 375, 750, 1500, or 2200 mg/kg/day for 4 days. Read More

Arch Virol 2019 Jan 19;164(1):317-319. Epub 2018 Sep 19.

Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi, 753-8515, Japan.

In a comprehensive research project on bat viruses, we successfully isolated a novel herpesvirus from the spleen of a greater horseshoe bat (Rhinolophus ferrumequinum) in Japan using a cell line established from the kidney of the same bat. This herpesvirus was a novel gammaherpesvirus (Rhinolophus gammaherpesvirus 1; RGHV-1), which belonged to the genus Percavirus. The whole RGHV-1 genome (147,790 bp) showed that 12 of the 84 genes predicted to contain open reading frames did not show any homology to those of other herpesviruses. Read More

Clin Nucl Med 2018 Nov;43(11):825-827

From the Department of Nuclear Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China.

A previously healthy 11-year-old boy with intermittent abdominal pain and bloody stool underwent Meckel scintigraphy. On the initial images, there was a faint U-shaped activity in the mid-abdominal region, which gradually faded and evolved into distinct foci of radiotracer accumulation in the later images. One of the foci changed its location during the study, suspected as moving Meckel diverticulum. Read More

An Pediatr (Barc) 2018 Aug 31. Epub 2018 Aug 31.

Servicio de Pediatría, Hospital de Mérida, Mérida, Badajoz, España. Electronic address:

Pan Afr Med J 2018;30:26. Epub 2018 May 15.

Department of Urology, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.

J Vasc Interv Radiol 2018 09;29(9):1288-1290.e1

Division of Radiology, University Hospital, One Hospital Drive, Columbia, MO 65212; Division of Body Imaging, University Hospital, One Hospital Drive, Columbia, MO 65212.

Ann R Coll Surg Engl 2018 Aug 16:e1-e3. Epub 2018 Aug 16.

Department of Urology, Ibn Sina Military Hospital , Marrakech , Morocco.

Crossed renal ectopia with fusion is an extremely rare congenital anomaly with few reported cases of pelviureteric junction obstruction, which often involves the crossed-over kidney. To our knowledge, we describe the second case in literature to report an uncrossed kidney with pelviureteric junction obstruction and giant hydronephrosis, which obstructs the pelviureteric junction of the crossed-over kidney. The grossly hydronephrotic kidney was found to be poorly functioning and an aberrant crossing vessel was considered to be potentially involved, raising both diagnostic and management challenges. Read More

Cureus 2018 Jun 9;10(6):e2775. Epub 2018 Jun 9.

Neurosurgery, Seattle Science Foundation, Seattle, USA.

Kidney development is a complex process that begins during the sixth to eighth weeks of life. Failure of ascent of the kidney will cause the kidney to remain in the pelvis i.e. Read More

Urol Case Rep 2018 Sep 27;20:98-99. Epub 2018 Jul 27.

Department of Urology, La Rabta Hospital, Tunisia.

Urol Ann 2018 Jul-Sep;10(3):287-290

Division of Pediatric Urology, Department of Urology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Purpose: The aim is to assess the outcomes of different approaches for the management of renal stones associated with horseshoe kidneys (HSKs) in our institution over a 12-year period.

Methods: A retrospective review of 144 patients with HSKs who presented from 2000 to 2012 was performed. Twenty-eight patients (19. Read More

Urol Ann 2018 Jul-Sep;10(3):258-262

Department of Urology, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India.

Purpose: To review our success in PCNL for managing large horse shoe kidney stones as primary treatment.

Method: Between 2012 and 2016, a total of 23patients (24 renal units) underwent percutaneous renal surgery for stone dieses in horseshoe kidneys. Indications were HSK with stone more than 1 cm in size and failed ESWL. Read More

Ann Vasc Surg 2019 Jan 4;54:110-117. Epub 2018 Aug 4.

Department of Vascular Surgery, University of Florida, Gainesville, FL.

Background: Renal artery anomalies occur at a rate of 1-2% and present a challenge to vascular surgeons performing aortic surgery. We describe adjuncts used to manage such anatomic variants.

Methods: A single surgeon registry of all abdominal aortic aneurysms repaired in an academic center was retrospectively reviewed. Read More

Aorta (Stamford) 2018 Feb 27;6(1):21-27. Epub 2018 Jul 27.

Vascular Surgery - Department of Surgical Sciences, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.

A 90-year-old male developed acute onset of abdominal and lumbar pain due to the rupture of an 11-cm abdominal aortic aneurysm. A congenital fused pelvic kidney perfused by three renal arteries arising from iliac axes was detected. In an emergent setting, an aorto-uni-iliac endograft was deployed through right femoral surgical access with occlusion of the upper right renal artery. Read More

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Department of Ob/Gyn, Texas Tech University Health Science Center School of Medicine, Amarillo, Texas, USA.

An 18-year-old virginal woman was referred to the reproductive endocrinology clinic with primary amenorrhoea and secondary sexual development in the absence of pelvic pain. Additionally, she had significant congenital sensorineural hearing loss, autism, bipolar disorder and class III obesity. On physical examination, secondary sexual development was confirmed (Tanner 5 breasts and Tanner 4 pubic hair). Read More

Cancer Sci 2018 Oct 26;109(10):3171-3182. Epub 2018 Aug 26.

Cell Biology Laboratory, School of Pharmacy, Kindai University, Higashiosaka, Osaka, Japan.

Although cancer metastasis is associated with poor prognosis, the mechanisms of this event, especially via lymphatic vessels, remain unclear. Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) is expressed on lymphatic vessel endothelium and is considered to be a specific marker of lymphatic vessels, but it is unknown how LYVE-1 is involved in the growth and metastasis of cancer cells. We produced rat monoclonal antibodies (mAb) recognizing the extracellular domain of mouse LYVE-1, and investigated the roles of LYVE-1 in tumor formation and metastasis. Read More

Surg Radiol Anat 2018 Oct 24;40(10):1185-1191. Epub 2018 Jul 24.

Department of Radiology, Barlicki University Hospital, Medical University of Łódź, Kopcińskiego Str. 22, 90-153, Lodz, Poland.

Purpose: Horseshoe kidney is a rare congenital anomaly with potential clinical implications. The aim of this study was to determine the number of renal arteries and veins and the level at which the arteries branched off their parental vessels in individuals with horseshoe kidney (HSK) and in persons with separated kidneys (SK).

Materials And Methods: The analysis included computed tomography angiography studies of 331 patients (83 HSK and 248 SK). Read More

J Minim Invasive Gynecol 2018 Jul 19. Epub 2018 Jul 19.

Department of Obstetrics and Gynaecology, Epsom & St. Helier's University Hospitals NHS Trust, Dorking Road, United Kingdom (all authors).. Electronic address:

Study Objective: To demonstrate our approach to laparoscopic excision of a noncommunicating rudimentary horn (American Society for Reproductive Medicine classification II(b), European Society of Human Reproduction and Embryology/European Society of Gynaecological Endoscop classification class U4a).

Design: Technical video (Canadian Task Force classification level III).

Setting: University Hospital. Read More