6,392 results match your criteria Horner Syndrome


Toward an Understanding of the Essential Components of Behavior Analytic Service Plans.

Behav Anal Pract 2018 Dec 20;11(4):436-444. Epub 2018 Apr 20.

3Western Michigan Univesity, Kalamazoo, MI USA.

Baer, Wolf, and Risley (1968) indicated "technological" was one of seven core dimensions of applied behavior analysis (ABA). They described this dimension as being met if interventions were described well enough to be implemented correctly. Often in the applied settings, a behavior plan is the method by which interventions are communicated to staff and parents for implementation. Read More

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December 2018

Draft Genome Sequences of Three Novel Staphylococcus arlettae Strains Isolated from a Disused Biological Safety Cabinet.

Microbiol Resour Announc 2018 Oct 4;7(13). Epub 2018 Oct 4.

Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council, Bari, Italy.

The genome sequences of three new strains of Staphylococcus arlettae named Bari1, Bari2, and Bari3 are presented. The strains exhibited tolerance to hexavalent chromium ions. An gene encoding a putative chromium transporter was present in each of the three draft genome sequences. Read More

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October 2018

Horner Syndrome Due to Spontaneous Internal Carotid Artery Dissection.

Cureus 2018 Sep 28;10(9):e3382. Epub 2018 Sep 28.

Neurology, University of Missouri, Columbia, USA.

Horner syndrome is a constellation of neurological findings consisting of ipsilateral ptosis, miosis, and anhidrosis. Partial Horner syndrome, comprising ipsilateral ptosis and miosis in the absence of anhidrosis, is a well-documented but uncommon manifestation of internal carotid artery dissection. We report the case of a 42-year-old male patient who presented with ipsilateral ptosis and miosis and was subsequently diagnosed with internal carotid artery dissection. Read More

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September 2018

Birth palsy in congenital varicella syndrome: A lesson in anatomy.

Indian J Plast Surg 2018 May-Aug;51(2):238-242

Department of Plastic Surgery, Hand and Microsurgery, Ganga Medical Centre and Hospitals, Coimbatore, Tamil Nadu, India.

While brachial plexus palsy sustained due to birth trauma is well known, congenital palsies are decidedly rare. We report such a case caused by congenital varicella syndrome, with associated congenital Horner's syndrome and heterochromia iridis. The surprising juxtaposition of a classic upper plexus palsy and a Horner's syndrome raises points of interest. Read More

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December 2018
1 Read

[Horner's syndrome as presentation of pulmonary tuberculosis].

Medicina (B Aires) 2018 ;78(6):447-448

Servicio de Medicina Interna, Clínica Universitaria Reina Fabiola, Córdoba, Argentina.

Horner's syndrome results from a blockage of the sympathetic innervation to the eye at any point along its trajectory. It presents various etiologies, and it is a very unusual form of presentation of pulmonary tuberculosis. We describe the case of a patient with a Horner syndrome secondary to involvement of the pulmonary apex due to tuberculosis. Read More

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January 2018
1 Read

Outcomes of hyaluronic acid injections for glenohumeral osteoarthritis: a systematic review and meta-analysis.

J Shoulder Elbow Surg 2018 Nov 28. Epub 2018 Nov 28.

Department of Surgery, McMaster University, Hamilton, ON, Canada. Electronic address:

Background: Hyaluronic acid (HA) is an analgesic and chondroprotective agent often used for the nonoperative treatment of osteoarthritis (OA). The effects of HA injections are well studied in the treatment of knee OA, but the effects in glenohumeral OA remain unclear. This study evaluated the efficacy of HA to reduce pain in patients with glenohumeral OA. Read More

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November 2018
1 Read

Assessment of different methods for the detection of biofilm production in coagulase-negative staphylococci isolated from blood cultures of newborns.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):761-767

Departamento de Análises Clínicas, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil.

Introduction: Coagulase-negative staphylococci (CoNS) are a frequent cause of bacteremia, especially in neonates. The major virulence determinant in CoNS is the ability to produce biofilms, which is conferred by the icaADBC genes. This study aimed to assess different methods for the detection of biofilm formation in 176 CoNS isolates from blood cultures of newborns. Read More

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Chikungunya infection and horner syndrome.

IDCases 2018 24;14:e00473. Epub 2018 Nov 24.

Pediatrics Department, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP) - Rua dos Coelhos, 300, Boa Vista, Recife, PE, Brazil.

We describe an infant with Chikungunya virus (CHIKV) infection who developed Horner syndrome. The infant had diagnostic confirmation of CHIKV infection by IgM-ELISA positive in serum and cerebrospinal fluid, and clinical signs of Horner syndrome. Magnetic resonance angiography showed alterations in the cervical and intra cavernous portions of the internal carotid artery. Read More

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November 2018
4 Reads

Maximizing Learning Opportunities in Interprofessional Clinical Environments Through Precepting.

J Contin Educ Nurs 2018 Dec;49(12):545-546

Effective precepting requires a separate skill set than being an expert clinician, which is something that is often overlooked. Deliberate preparation should include utilization of effective communication techniques, teaching using powerful questions, developing skills for feedback and evaluation, as well as others. Becoming a highly functioning member of an interprofessional team requires special consideration and preparation that can enhance the nurses' role. Read More

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December 2018
4 Reads

SMRT long reads and Direct Label and Stain optical maps allow the generation of a high-quality genome assembly for the European barn swallow (Hirundo rustica rustica).

Gigascience 2018 Nov 29. Epub 2018 Nov 29.

Department of Environmental Science and Policy, University of Milan, Milan, Italy.

Background: The barn swallow (Hirundo rustica) is a migratory bird that has been the focus of a large number of ecological, behavioural and genetic studies. To facilitate further population genetics and genomic studies, here we present a reference genome assembly for the European subspecies (H. r. Read More

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November 2018
1 Read

Prevalence and short-term changes of cognitive dysfunction in young ischemic stroke patients.

Eur J Neurol 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurology, Medical University of Graz, Graz, Austria.

Background: Information on the prevalence and course of post-stroke cognitive impairment in young stroke patients is limited. We aimed to assess a consecutive sample of acute young ischemic stroke patients (18 to 55 years) for the presence and development of neuropsychological deficits.

Methods: Patients prospectively underwent a comprehensive clinical and cognitive assessment, examining general cognitive function, processing speed, attention, flexibility/executive function and word fluency within the first three weeks after hospital admission (median assessment at day six) and at a three months follow-up (FU). Read More

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November 2018
9 Reads

Horner Syndrome After Anterior Revision Surgery for Cervical Spondylotic Myelopathy: A Very Rare Complication: A Case Report.

JBJS Case Connect 2018 Nov 28. Epub 2018 Nov 28.

Spinal Unit, Department of Orthopaedics, Centro Hospitalar do Porto-Hospital Geral de Santo António, Porto, Portugal.

Case: We report a case of postoperative left-sided Horner syndrome (blepharoptosis, miosis, and anhidrosis) after revision surgery for cervical spondylotic myelopathy. A C4 corpectomy and an anterior cervical fusion from C3 to C5 were performed through a left longitudinal approach in a patient with a surgical history of an anterior discectomy and a fusion from C5 to C6. One year after the revision surgery, the patient had recovered from the anhidrosis and the miosis, but the blepharoptosis was not fully resolved. Read More

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November 2018
1 Read

Slow spin crossover in bis-meridional Fe complexes through spin-state auto-adaptive N6/N8 coordination.

Dalton Trans 2018 Dec 29;47(48):17257-17265. Epub 2018 Nov 29.

TU Chemnitz, Institut für Chemie, Anorganische Chemie, Straße der Nationen 62, 09111 Chemnitz, Germany.

Fe spin crossover (SCO) complexes with long-lived excited high-spin (HS) states are promising molecular switches. An enhanced kinetic stability of spin-state isomers can be expected to foster applications beyond the limits of cooperative SCO. In this study, we describe a new approach to slow down the spin-state exchange by simple commutation of a phenyl substituent by a pyridyl substituent. Read More

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December 2018
1 Read

Organocatalytic and Scalable Syntheses of Unsymmetrical 1,2,4,5-Tetrazines by Thiol-containing Promotors.

Angew Chem Int Ed Engl 2018 Nov 28. Epub 2018 Nov 28.

Sichuan University, West China hospital, 1 Forth Keyuan road, 610000, chengdu, CHINA.

Despite the growing application of tetrazine bioorthogonal chemistry, it is still challenging to access tetrazines conveniently from easily available materials. Here we describe de novo formation of tetrazine from nitriles and hydrazine hydrate using a broad array of thiol-containing catalysts, including peptides. Using this facile methodology, we describe 14 syntheses of unsymmetric tetrazines containing a range of reactive functional groups on the gram scale with satisfactory yield. Read More

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November 2018
1 Read

Controlled trial of the impact of a BC adult mental health practice support program (AMHPSP) on primary health care professionals' management of depression.

BMC Fam Pract 2018 Nov 28;19(1):183. Epub 2018 Nov 28.

University of Calgary, Calgary, Alberta, Canada.

Background: Depression affects over 400 million people globally. The majority are seen in primary care. Barriers in providing adequate care are not solely related to physicians' knowledge/skills deficits, but also time constraints, lack of confidence/avoidance, which need to be addressed in mental health-care redesign. Read More

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November 2018
3 Reads

Resorcinol alkyl glucosides as potent tyrosinase inhibitors.

Bioorg Med Chem Lett 2018 Nov 14. Epub 2018 Nov 14.

Department of Applied Biological Chemistry, School of Agriculture, Utsunomiya University, Tochigi 321-0943, Japan; Department of Applied Life Science, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan. Electronic address:

Resorcinol alkyl glucosides 7-12 were developed as novel tyrosinase inhibitors based on the structure of rhododendrin. These were synthesized from 2,4-dibenzyloxybenzaldehyde using either the Wittig or the Horner-Wadsworth-Emmons reaction with Koenigs-Knorr glycosylation as key steps. The tyrosinase inhibitory activity of 7-12 increased with the length of the alkyl spacer between resorcinol and glucose. Read More

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November 2018
4 Reads

High school personality traits and 48-year all-cause mortality risk: results from a national sample of 26 845 baby boomers.

J Epidemiol Community Health 2018 Nov 20. Epub 2018 Nov 20.

American Institute for Research, Washington DC, District of Columbia, USA.

Background: It is unclear if adolescent personality predicts mortality into late life, independent of adolescent socioeconomic status (SES).

Methods: Over 26 000 members of Project Talent, a US population cohort of high school students, completed a survey including 10 personality scales and SES in 1960. Multi-source mortality follow-up obtained vital status data through an average 48-year period ending in 2009. Read More

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November 2018
2 Reads

pH-sensitive polymer micelles provide selective and potentiated lytic capacity to venom peptides for effective intracellular delivery.

Biomaterials 2018 Nov 9;192:235-244. Epub 2018 Nov 9.

Department of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA, 98195, United States. Electronic address:

Endocytosed biomacromolecule delivery systems must escape the endosomal trafficking pathway in order for their cargo to exert effects in other cellular compartments. Although endosomal release is well-recognized as one of the greatest barriers to efficacy of biologic drugs with intracellular targets, most drug carriers have relied on cationic materials that passively induce endosomal swelling and membrane rupture with low efficiency. To address the endosome release challenge, our lab has developed a diblock copolymer system for nucleic acid delivery that selectively displays a potent membrane-lytic peptide (melittin) in response to the pH drop during the endosomal maturation. Read More

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November 2018
5 Reads

High Cancer Burden Among Antiretroviral Therapy Users in Malawi: a Record Linkage Study of Observational HIV Cohorts and Cancer Registry Data.

Clin Infect Dis 2018 Nov 17. Epub 2018 Nov 17.

Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, United States.

Background: With antiretroviral therapy (ART), AIDS-defining cancer incidence has declined and non-AIDS defining cancers are now more frequent among HIV-infected populations in high-income countries. In sub-Saharan Africa, limited epidemiological data describe cancer burden among ART users.

Methods: We used probabilistic algorithms to link cases from the population-based cancer registry with electronic medical records supporting ART delivery in the Malawi's two largest HIV cohorts, Lighthouse Trust (LT; 2007-2010) and Queen Elizabeth Central Hospital (QECH; 2000-2010). Read More

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November 2018
3 Reads
8.890 Impact Factor

Temperature Measurements: Comparison of Different Thermometer Types for Patients With Cancer.

Clin J Oncol Nurs 2018 Dec;22(6):611-617

Emory University.

Background: Accurate temperature measurement in patients with cancer is critical. Many patients are neutropenic; therefore, fever represents an oncologic emergency, and, in many cases, it can be the only indication of a life-threatening infection. Although oral thermometers most closely represent true core temperature, patients may have barriers to oral thermometry. Read More

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December 2018
1 Read

Effect Of Incident Field Magnitude And Phase Distribution On Rfinduced Heating Due To Hip Implants.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:1360-1363

We investigated how the distribution of magnitude and phase of incident electric field affects RFinduced heating near a hip implant. The results showed that varying the incident electric field, for example due to different phantom shape or different landmark position, for two-or three-dimensional implants can result in up to 50% variation of estimated RF-induced temperature rise. To avoid systematic errors in predicting the RF-induced heating, varied distributions of the incident electric field should be applied. Read More

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July 2018
1 Read

Isolated Horner syndrome as a rare initial presentation of nasopharyngeal carcinoma: a case report.

Int Med Case Rep J 2018 18;11:271-276. Epub 2018 Oct 18.

Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand,

Background: Horner syndrome refers to a set of clinical presentations resulting from disruption of sympathetic innervation to the eye and adnexa. Classically, the clinical triad consists of ipsilateral blepharoptosis, pupillary miosis, and facial anhidrosis. Ocular sympathetic denervation may signify life-threatening causes. Read More

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October 2018
1 Read

Verbal long-term memory is enhanced by retrieval practice but impaired by prefrontal direct current stimulation.

Brain Cogn 2018 12 8;128:80-88. Epub 2018 Nov 8.

Tufts University, Department of Psychology, Medford, MA 02155, USA.

Retrieval practice involves repeatedly testing a student during the learning experience, reliably conferring learning advantages relative to repeated study. Transcranial direct current stimulation (tDCS) of the left dorsolateral prefrontal cortex (dlPFC) has also been shown to confer learning advantages for verbal memory, though research is equivocal. The present study examined the effects of retrieval versus study practice with or without left dlPFC tDCS on verbal episodic memory. Read More

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December 2018

Comprehensive strategy to reduce the incidence of lead dislodgement for cardiac implantable electronic devices.

Pacing Clin Electrophysiol 2018 Nov 10. Epub 2018 Nov 10.

Division of Cardiovascular Medicine, Department of Internal Medicine, Electrophysiology Section, Ross Heart Hospital, The Wexner Medical Center at the Ohio State University Medical Center, Columbus, OH, USA.

Background: Lead dislodgement (LD) is a well-recognized complication during implantation of cardiac implantable electronic devices (CIEDs). An intraprocedural protocol, referred to as reduction of LD protocol, was developed to reduce the risk of LD.

Methods: The protocol involved (1) inserting a straight stylet down the right atrial lead and applying forward pressure while monitoring for fluoroscopic stability, (2) visualizing all leads during deep inspiration to determine if there is adequate lead redundancy, and (3) having the patient take a deep breath and cough while pacing just at capture threshold to assess for loss of capture in each lead. Read More

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November 2018
7 Reads

Trichoteiromania: An Atypical Case Associated with the Claude Bernard Horner Syndrome.

Skin Appendage Disord 2018 Oct 15;4(4):342-344. Epub 2017 Dec 15.

Hospital do Servidor Público Estadual de São Paulo, São Paulo, Brazil.

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October 2018
2 Reads

Genomic Surveillance of Enterococcus faecium Reveals Limited Sharing of Strains and Resistance Genes between Livestock and Humans in the United Kingdom.

MBio 2018 Nov 6;9(6). Epub 2018 Nov 6.

Department of Medicine, University of Cambridge, Cambridge, United Kingdom

Vancomycin-resistant (VREfm) is a major cause of nosocomial infection and is categorized as high priority by the World Health Organization global priority list of antibiotic-resistant bacteria. In the past, livestock have been proposed as a putative reservoir for drug-resistant strains that infect humans, and isolates of the same lineage have been found in both reservoirs. We undertook cross-sectional surveys to isolate (including VREfm) from livestock farms, retail meat, and wastewater treatment plants in the United Kingdom. Read More

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November 2018
2 Reads

A fully coupled fluid-structure interaction model of the secondary lymphatic valve.

Comput Methods Biomech Biomed Engin 2018 Nov 6:1-11. Epub 2018 Nov 6.

a Department of Bioengineering , Imperial College London , London , UK.

The secondary lymphatic valve is a bi-leaflet structure frequent throughout collecting vessels that serves to prevent retrograde flow of lymph. Despite its vital function in lymph flow and apparent importance in disease development, the lymphatic valve and its associated fluid dynamics have been largely understudied. The goal of this work was to construct a physiologically relevant computational model of an idealized rat mesenteric lymphatic valve using fully coupled fluid-structure interactions to investigate the relationship between three-dimensional flow patterns and stress/deformation within the valve leaflets. Read More

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November 2018
3 Reads

coiled-coil peptides as scaffolds for disrupting protein-protein interactions.

Chem Sci 2018 Oct 7;9(39):7656-7665. Epub 2018 Aug 7.

School of Chemistry , University of Bristol , Cantock's Close , Bristol BS8 1TS , UK . Email: ; Email:

Protein-protein interactions (PPIs) play pivotal roles in the majority of biological processes. Therefore, improved approaches to target and disrupt PPIs would provide tools for chemical biology and leads for therapeutic development. PPIs with α-helical components are appealing targets given that the secondary structure is well understood and can be mimicked or stabilised to render small-molecule and constrained-peptide-based inhibitors. Read More

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October 2018
9 Reads

The relationship between episodic future thinking and prospective memory in middle childhood: Mechanisms depend on task type.

J Exp Child Psychol 2019 Feb 30;178:198-213. Epub 2018 Oct 30.

Cognition and Emotion Research Centre, School of Psychology, Australian Catholic University, Melbourne Campus, Fitzroy, VIC 3065, Australia.

Episodic future thinking (EFT), the ability to imagine experiencing a future event, and prospective memory (PM), the ability to remember and carry out a planned action, are core aspects of future-oriented cognition that have individually been the focus of research attention in the developmental literature. However, the relationship between EFT and PM, including the extent to which it varies with PM task type, remains poorly delineated, particularly in middle childhood. The current study tested this relationship in 62 typically developing children aged 8-12 years. Read More

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February 2019
2 Reads

Five-factor structure of the RBANS is supported in an Alzheimer's disease sample: Implications for validation of neuropsychological assessment instruments.

Appl Neuropsychol Adult 2018 Oct 31:1-11. Epub 2018 Oct 31.

a Ralph H. Johnson Department of Veterans Affairs Medical Center , Charleston , South Carolina , USA.

Development of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was theoretically driven, with the goal of providing an assessment of abilities across five cognitive domains. Since its development, numerous factor analytic studies have failed to provide empirical support for the proposed five-factor structure and, furthermore, have lacked consensus on the internal structure of this instrument. A key limitation of these prior studies is the use of normal or mixed clinical samples, a practice that can obscure distinctions that may be evident in specific homogeneous clinical samples. Read More

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October 2018
1 Read

Unusual case of traumatic carotid artery dissection occurred during a work-related activity. A case report.

Med Lav 2018 Oct 30;110(5):387-390. Epub 2018 Oct 30.

.

Carotid artery dissection secondary to cervical blunt trauma is a rare and potentially life-threatening condition that can cause a variety of clinical presentations, including stroke, headache, neck pain, tinnitus, Horner syndrome and cranial neuropathies and is associated with long-term sequelae. We report a case of a 49-year-old industrial vehicles mechanic who was projected to the ground by the explosion of the tire of a heavy truck he was inflating. In the following hours he presented various neurological signs and symptoms and was admitted to the Emergency Department. Read More

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October 2018
2 Reads

Unrecognised myocardial infarction and its relationship to outcome in critically ill patients with cardiovascular disease.

Intensive Care Med 2018 Dec 29;44(12):2059-2069. Epub 2018 Oct 29.

Department of Anaesthesia, Critical Care and Pain Medicine, University of Edinburgh, 2nd Floor Anaesthetics Corridor, Royal Infirmary Edinburgh, Old Dalkeith Road, Edinburgh, EH16 4SA, UK.

Purpose: To establish the incidence of myocardial infarction (MI) in ICU patients with co-existing cardiovascular disease (CVD), and explore its association with long-term survival.

Methods: In a multi-centre prospective cohort study in 11 UK ICUs, we enrolled 273 critically ill patients with co-existing CVD. We measured troponin I (cTnI) with a high sensitivity assay for 10 days; ECGs were carried out daily for 5 days and analysed by blinded cardiologists for dynamic changes. Read More

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December 2018
5 Reads

Concise synthesis of 23-hydroxylated vitamin D metabolites.

J Steroid Biochem Mol Biol 2018 Oct 24. Epub 2018 Oct 24.

Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan; AMED-CREST, AMED, Japan. Electronic address:

Three 23-hydroxylated vitamin D derivatives, which are metabolites of 25-hydroxyvitamin D produced by CYP24A1 and a related diastereomer, were efficiently synthesized. Each C23 hydroxy unit was constructed by the Claisen condensation reaction with ethyl acetate or the Grignard reaction with 2-methylallymagnesium chloride. Stereochemistry at the C23 position was determined by a modified Mosher's method. Read More

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October 2018
5 Reads

Design, synthesis and anti-melanogenic effect of cinnamamide derivatives.

Bioorg Med Chem 2018 Nov 19;26(21):5672-5681. Epub 2018 Oct 19.

Laboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan 46241, South Korea. Electronic address:

Pigmentation disorders are attributed to excessive melanin which can be produced by tyrosinase. Therefore, tyrosinase is supposed to be a vital target for the treatment of disorders associated with overpigmentation. Based on our previous findings that an (E)-β-phenyl-α,β-unsaturated carbonyl scaffold can play a key role in the inhibition of tyrosinase activity, and the fact that cinnamic acid is a safe natural substance with a scaffolded structure, it was speculated that appropriate cinnamic acid derivatives may exhibit potent tyrosinase inhibitory activity. Read More

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November 2018
7 Reads

An Approach toward the Synthesis of the Spiroimine Fragment of 13-Desmethylspirolide C and Gymnodimine A.

Chemistry 2018 Oct 25. Epub 2018 Oct 25.

Universite de Bordeaux, IECB, FRANCE.

A general access to the spiroimine skeleton of gymnodimine and spirolides is described relying on the construction of the cyclohexene fragment using an enantiocontrolled Diels-Alder reaction, the installation of the all-carbon quaternary stereocenter through a stereocontrolled alkylation or aldolisation and the elaboration of the lateral chains at C7 and C22 using Wittig-Horner olefinations. The spiroimine core of gymnodimine is thus made available through a 16 steps linear sequence in a 21% overall yield. Read More

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October 2018

Oxygen therapy for medical patients.

BMJ 2018 Oct 24;363:k4436. Epub 2018 Oct 24.

Salford Royal NHS Foundation Trust, Salford, UK.

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October 2018

Abnormal Blood Flow on Transcranial Duplex Sonography Predicts Poor Outcome After Stroke Thrombectomy.

Stroke 2018 Nov;49(11):2780-2782

From the Department of Neurology (M.K., K.N., C.E., B.P., S.H., D.T., J.K., S.F., I.C., F.F., T.G.), Medical University of Graz, Austria.

Background and Purpose- Hemodynamic changes following mechanical thrombectomy for large vessel occlusion stroke could be associated with complications and might affect prognosis. We investigated postinterventional middle cerebral artery blood flow on transcranial duplex sonography (TCD) and its prognostic value for anterior large vessel occlusion stroke patients. Methods- We identified all ischemic stroke patients who had undergone mechanical thrombectomy for anterior circulation large vessel occlusion from 2010 onwards. Read More

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November 2018
5 Reads

Synthesis of Indole-, Benzo[ b]thiophene-, and Benzo[ b]selenophene-Based Analogues of the Resveratrol Dimers Viniferifuran and (±)-Dehydroampelopsin B.

Org Lett 2018 Nov 15;20(21):6650-6654. Epub 2018 Oct 15.

Department of Chemistry , Umeå University , Umeå 90187 , Sweden.

A convenient synthetic strategy to obtain viniferifuran and (±)-dehydroampelopsin B analogues based on the heterocyclic cores of indole, benzo[ b]thiophene, and benzo[ b]selenophene is presented. The key transformations utilized in the described syntheses include Sonogashira couplings, Cacchi and alkyne electrophilic cyclizations, Horner-Wadsworth-Emmons (HWE) reaction, chemoselective Suzuki-Miyaura couplings, and acid-promoted intramolecular cyclization to form the seven-membered ring of (±)-dehydroampelopsin B. Read More

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November 2018
1 Read

Phthalates and organophosphates in settled dust and HVAC filter dust of U.S. low-income homes: Association with season, building characteristics, and childhood asthma.

Environ Int 2018 Dec 20;121(Pt 1):916-930. Epub 2018 Oct 20.

Department of Civil, Architectural and Environmental Engineering, The University of Texas at Austin, TX, USA; Department of Building Science, Tsinghua University, Beijing, China. Electronic address:

Phthalates and organophosphates are ubiquitous indoor semi-volatile organic contaminants (SVOCs) that have been widely used as plasticizers and flame retardants in consumer products. Although many studies have assessed their levels in house dust, only a few used dust samples captured by filters of building heating, ventilation, and air conditioning (HVAC) systems. HVAC filters collect particles from large volumes of air over a long period of time (potentially known) and thus provide a spatially and temporally integrated concentration. Read More

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December 2018
5 Reads
5.560 Impact Factor

Synthesis of cinnamic amide derivatives and their anti-melanogenic effect in α-MSH-stimulated B16F10 melanoma cells.

Eur J Med Chem 2019 Jan 15;161:78-92. Epub 2018 Oct 15.

Laboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan, 46241, South Korea. Electronic address:

Of the three enzymes that regulate the biosynthesis of melanin, tyrosinase and its related proteins TYRP-1 and TYRP-2, tyrosinase is the most important because of its ability to limit the rate of melanin production in melanocytes. For treating skin pigmentation disorders caused by an excess of melanin, the inhibition of tyrosinase enzyme is by far the most established strategy. Cinnamic acid is a safe natural product with an (E)-β-phenyl-α,β-unsaturated carbonyl motif that we have previously shown to play an important role in high tyrosinase inhibition. Read More

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January 2019
9 Reads

Improvement of normothermic ex vivo machine perfusion of rat liver grafts by dialysis and Kupffer Cell inhibition with glycine.

Liver Transpl 2018 Oct 20. Epub 2018 Oct 20.

Charité - Universitätsmedizin Berlin, Department of Surgery, Campus Charité Mitte| Campus Virchow-Klinikum, Experimental Surgery, Berlin, Germany.

Normothermic ex vivo liver machine perfusion might be a superior preservation strategy for liver grafts from extended criteria donors. However, standardized small animal models are not available for basic research on machine perfusion of liver grafts. A laboratory-scaled perfusion system was developed consisting of a custom-made perfusion chamber, a pressure-controlled roller pump, and an oxygenator. Read More

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October 2018
4 Reads

Pervasive tertiary structure in the dengue virus RNA genome.

Proc Natl Acad Sci U S A 2018 11 19;115(45):11513-11518. Epub 2018 Oct 19.

Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599;

RNA virus genomes are efficient and compact carriers of biological information, encoding information required for replication both in their primary sequences and in higher-order RNA structures. However, the ubiquity of RNA elements with higher-order folds-in which helices pack together to form complex 3D structures-and the extent to which these elements affect viral fitness are largely unknown. Here we used single-molecule correlated chemical probing to define secondary and tertiary structures across the RNA genome of dengue virus serotype 2 (DENV2). Read More

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November 2018
2 Reads

Adherence to inhaled therapy and its impact on chronic obstructive pulmonary disease (COPD).

BMC Pulm Med 2018 Oct 19;18(1):163. Epub 2018 Oct 19.

Department of Pulmonology, Kepler University Hospital, Krankenhausstrasse 9, A4021, Linz, Austria.

Background: COPD is a treatable disease with increasing prevalence worldwide. Treatment aims to stop disease progression, to improve quality of life, and to reduce exacerbations. We aimed to evaluate the association of the stage of COPD on adherence to inhaled therapy and the relationship between adherence and COPD exacerbations. Read More

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October 2018
4 Reads

IS26 mediated antimicrobial resistance gene shuffling from the chromosome to a mosaic conjugative FII plasmid.

Plasmid 2018 Nov 16;100:22-30. Epub 2018 Oct 16.

Department of Biology, University of Bari, via Orabona, 4, Bari 70125, Italy. Electronic address:

In the present study we report the identification of a sul3-associated class 1 integron containing the dfrA12-orfF-aadA2-cmlA1-aadA1-qacH array embedded in a Tn21-derived element that is part of a conjugative FII plasmid named pST1007-1A. The plasmid was identified in the Salmonella Typhimurium strain ST1007, a member of a clinically relevant clonal MDR lineage diffuse in Italy. ST1007 exhibited resistance to ampicillin, chloramphenicol, streptomycin, sulphamethoxazole, tetracycline and trimethoprim encoded by bla, cmlA1, (aadA1, aadA2, strAB), (sul2, sul3), tet(B) and dfrA12 genes, respectively. Read More

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November 2018
1 Read

Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis.

Authors:
Jing Li

Crit Care 2018 Oct 11;22(1):258. Epub 2018 Oct 11.

Santa Barbara Cottage Hospital, P.O. Box 689, Santa Barbara, CA, 93102, USA.

Two recent publications by Sheikh and Horner and Teng et al. reviewed studies on incorporating vitamin C to treat septic patients; however, a meta-analysis was not offered in either report. This commentary extends both reviews by integrating a meta-analysis and sharing aggregated results. Read More

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October 2018
8 Reads

Increased antimicrobial resistance in Klebsiella pneumoniae from a University Hospital in Rio Grande do Sul, Brazil.

Rev Soc Bras Med Trop 2018 Sep-Oct;51(5):676-679

Universidade Federal de Santa Maria, Laboratório de Bacteriologia, Departamento de Análises Clínicas e Toxicológicas, Santa Maria, RS, Brasil.

Introduction: The spread of multidrug-resistant Gram-negative bacilli is a health threat, limiting therapeutic options and increasing morbimortality rates.

Methods: This study aimed to evaluate the antimicrobial susceptibility profile of 1805 Klebsiella pneumoniae isolates collected from Hospital Universitário de Santa Maria between January 2015 and December 2016.

Results: Resistance to colistin (239. Read More

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October 2018
1 Read

Influence of Graft Source on Postoperative Activity and Joint Laxity in Posterior Cruciate Ligament Reconstruction: A Systematic Review.

Arthroscopy 2018 Oct 5. Epub 2018 Oct 5.

MedSport, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, U.S.A.. Electronic address:

Purpose: To compare the clinical and functional outcomes of allograft and autograft reconstruction in patients with posterior cruciate ligament (PCL) deficiency.

Methods: The MEDLINE, Embase, and Cochrane Library databases were used to identify all relevant articles. Clinical outcomes including International Knee Documentation Committee, Tegner, and Lysholm scores; joint laxity; and posterior tibial displacement were evaluated. Read More

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October 2018
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3.210 Impact Factor

Return to Play and In-Game Performance Statistics Among Pitchers After Ulnar Collateral Ligament Reconstruction of the Elbow: A Systematic Review.

Am J Sports Med 2018 Oct 5:363546518798768. Epub 2018 Oct 5.

Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.

Background: Injury to the ulnar collateral ligament of the elbow is relatively common among baseball pitchers. Ulnar collateral ligament reconstruction (UCLR) has revolutionized the management of this injury, allowing a greater proportion of pitchers to return to play.

Purpose: To assess the return to play and in-game performance specific to baseball pitchers who have undergone primary UCLR. Read More

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October 2018
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