4,143 results match your criteria Hormones and Behavior[Journal]


Aggression: Perspectives from social and systems neuroscience.

Horm Behav 2019 Apr 16. Epub 2019 Apr 16.

Department of Biology, Bowdoin College, Brunswick, ME 04011, USA.

Exhibiting behavioral plasticity in order to mount appropriate responses to dynamic and novel social environments is crucial to the survival of all animals. Thus, how animals regulate flexibility in the timing, duration, and intensity of specific behaviors is of great interest to biologists. In this review, we discuss how animals rapidly respond to social challenges, with a particular focus on aggression. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.04.010DOI Listing
April 2019
1 Read

Sex-specific differences in adult cognition and neuroplasticity following repeated combinatory stress and TrkB receptor antagonism in adolescence.

Horm Behav 2019 Apr 14. Epub 2019 Apr 14.

Behavioral Neuroscience Group, School of Psychology, University of Ottawa, 136 Jean-Jacques Lussier, Ottawa, ON, Canada. Electronic address:

Evidence supports brain-derived neurotrophic factor (BDNF) and its primary receptor tyrosine-related kinase B (TrkB) as targets in the treatment of mood disorders. This study characterized the impact of a 10-day combinatory stress paradigm (alternating days of restraint stress and forced swim) and administration of the selective TrkB antagonist ANA-12 (0.5 mg/kg, i. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.04.006DOI Listing
April 2019
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Recovery periods during repeated stress impact corticosterone and behavioral responses differently in house sparrows.

Horm Behav 2019 Apr 17;112:81-88. Epub 2019 Apr 17.

Department of Biology, Tufts University, Medford, MA 02155, USA.

A number of studies have shown that chronic stress can negatively impact both physiology and behavior in a variety of organisms. What has yet to be extensively explored is whether these changes permanently alter an animal's functioning, or if they can be reversed. In this study, we used wild-caught house sparrows (Passer domesticus) to assess how recovery periods influence the physiological and behavioral impacts of an initial four days and subsequent four days of repeated stressors. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.04.009DOI Listing

Plasma membrane G protein-coupled estrogen receptor 1 (GPER) mediates rapid estradiol facilitation of sexual receptivity through the orphanin-FQ-ORL-1 system in estradiol primed female rats.

Horm Behav 2019 Apr 11. Epub 2019 Apr 11.

Department of Biological Sciences, California State University, Long Beach, Long Beach, CA, United States of America. Electronic address:

In estradiol primed nonreceptive ovariectomized rats, activation of G protein-coupled estrogen receptor 1 (GPER) in the arcuate nucleus of the hypothalamus (ARH) rapidly facilitates sexual receptivity (lordosis). Estradiol priming activates ARH β-endorphin (β-END) neurons that in turn, activate medial preoptic (MPN) μ-opioid receptors (MOP) to inhibit lordosis. ARH infusion of non-esterified 17β-estradiol (E2) 47. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.04.004DOI Listing
April 2019
4 Reads

Frank Beach Award Winner - The future of mental health research: Examining the interactions of the immune, endocrine and nervous systems between mother and infant and how they affect mental health.

Authors:
Jaclyn M Schwarz

Horm Behav 2019 Apr 11. Epub 2019 Apr 11.

University of Delaware, Department of Psychological and Brain Sciences, 108 Wolf Hall, Newark, DE 19716, USA. Electronic address:

Pregnancy and the postpartum period are periods of significant change in the immune and endocrine systems. This period of life is also associated with an increased risk of mental health disorders in the mother, and an increased risk of developmental and neuropsychiatric disorders in her infant. The collective data described here supports the idea that peripartum mood disorders in mother and developmental disorders in her infant likely reflects multiple pathogeneses, stemming from various interactions between the immune, endocrine and nervous systems, thereby resulting in various symptom constellations. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.04.008DOI Listing

Within- and between-person variation in morning testosterone is associated with economic risk-related decisions in athletic women across the menstrual cycle.

Horm Behav 2019 Apr 16;112:77-80. Epub 2019 Apr 16.

Hamlyn Centre, Imperial College, UK; Institute of Sport - National Research Institute, Warsaw, Poland. Electronic address:

Literature suggests that women experience ovulatory shifts in risk-taking behaviours across different domains, which might be partly attributed to changes in testosterone (T). Thus, we investigated associations between menstrual variability in T concentrations and economic risk-related decisions among athletic women. Thirty-five women were monitored across three consecutive menstrual cycles. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.04.007DOI Listing

Mothers are sensitive to men's beards as a potential cue of paternal investment.

Horm Behav 2019 Apr 9. Epub 2019 Apr 9.

School of Psychology, The University of Queensland, St. Lucia, Brisbane 4072, QLD, Australia.

Mating strategy theories assert that women's preferences for androgen dependent traits in men are stronger when the costs of reduced paternal investment are lowest. Past research has shown that preferences for facial masculinity are stronger among nulliparous and non-pregnant women than pregnant or parous women. In two studies, we examine patterns in women's preferences for men's facial hair - likely the most visually conspicuous and sexually dimorphic of men's secondary sexual traits - when evaluating men's masculinity, dominance, age, fathering, and attractiveness. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.04.005DOI Listing
April 2019
4 Reads

Fathers: The interplay between testosterone levels and self-control in relation to parenting quality.

Horm Behav 2019 Apr 9. Epub 2019 Apr 9.

Education and Child Studies, Leiden University, the Netherlands. Electronic address:

In this study, we examined the potential interaction effect between fathers' basal testosterone levels and their ability to control their impulses in relation to their quality of parenting. Participants included 159 fathers and their preschoolers. Evening and morning salivary samples were analyzed with isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) to determine basal testosterone (T) levels. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.04.003DOI Listing
April 2019
3 Reads

Active feminization of the preoptic area occurs independently of the gonads in Amphiprion ocellaris.

Horm Behav 2019 Apr 10;112:65-76. Epub 2019 Apr 10.

Department of Psychology, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana, Champaign, 405 N. Mathews Ave, Urbana, IL 61801, USA. Electronic address:

Sex differences in the anatomy and physiology of the vertebrate preoptic area (POA) arise during development, and influence sex-specific reproductive functions later in life. Relative to masculinization, mechanisms for feminization of the POA are not well understood. The purpose of this study was to induce sex change from male to female in the anemonefish Amphiprion ocellaris, and track the timing of changes in POA cytoarchitecture, composition of the gonads and circulating sex steroid levels. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.04.002DOI Listing
April 2019
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The effects of different rearing conditions on sexual maturation and maternal care in heterozygous mineralocorticoid receptor knockout mice.

Horm Behav 2019 Apr 10;112:54-64. Epub 2019 Apr 10.

Dept. Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Faculty of Social and Behavioural Sciences, Leiden University, Leiden, the Netherlands. Electronic address:

Sexual and social development is affected by a complex interplay between genetic makeup and the early-life rearing environment. While many rodent studies focused primarily on the detrimental effects of early-life stress, human literature suggests that genetic susceptibility may not be restricted to negative environments; it may also enhance the beneficial effects of positive rearing conditions. To examine this interaction in a controlled setting, heterozygous mineralocorticoid receptor knockout (MR) mice and control litter mates were exposed to a limited nesting/bedding (LN, impoverished), standard nesting (SN, control) or communal nesting (CN, enriched) paradigm from postnatal day 2-9 (P2-P9). Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.04.001DOI Listing

Effect of adolescent androgen manipulation on psychosis-like behaviour in adulthood in BDNF heterozygous and control mice.

Horm Behav 2019 Mar 30;112:32-41. Epub 2019 Mar 30.

Department of Psychiatry, Monash University, Melbourne, Australia.

Rationale: Males are more prone to psychosis, schizophrenia and substance abuse and addiction in adolescence and early adulthood than females. However, the role of androgens during this developmental period is poorly understood.

Objectives: This study aimed to examine how androgens in adolescence influence psychosis-like behaviour in adulthood and whether brain-derived neurotrophic factor (BDNF) is a mediator of these developmental effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0018506X183046
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http://dx.doi.org/10.1016/j.yhbeh.2019.03.005DOI Listing
March 2019
6 Reads

GnRH expression and cell proliferation are associated with seasonal breeding and food hoarding in Mongolian gerbils (Meriones unguiculatus).

Horm Behav 2019 Mar 30;112:42-53. Epub 2019 Mar 30.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Seasonal brain plasticity contributes to a variety of physiological and behavioral processes. We hypothesized that variations in GnRH expression and cell proliferation facilitated seasonal breeding and food hoarding. Here, we reported seasonal changes in sexual and social behavior, GnRH expression and brain cell proliferation, and the role of photoperiod in inducing seasonal breeding and brain plasticity in Mongolian gerbils (Meriones unguiculatus). Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.03.003DOI Listing

Special issue resulting from the 22nd Annual Meeting of the Society for Behavioral Neuroendocrinology highlights society strengths.

Authors:
Kim L Huhman

Horm Behav 2019 Mar 30. Epub 2019 Mar 30.

Neuroscience Institute, Georgia State University, Atlanta, GA 30303, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.yhbeh.2019.03.002DOI Listing

Beneficial effects of Spirulina platensis, voluntary exercise and environmental enrichment against adolescent stress induced deficits in cognitive functions, hippocampal BDNF and morphological remolding in adult female rats.

Horm Behav 2019 Mar 30;112:20-31. Epub 2019 Mar 30.

Laboratory of Learning and Memory, Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran; Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran. Electronic address:

Chronic exposure to stress during adolescent period has been demonstrated to impair cognitive functions and the dendritic morphology of pyramidal neurons in the rat hippocampal CA3 area. The present study investigated the combined protective effects of Spirulina platensis (SP), a supplement made from blue-green algae with neuroprotective properties, voluntary exercise (EX) and environmental enrichment (EE) against cognitive deficits, alternations in hippocampal BDNF levels, and abnormal neuronal remodeling in adult female rats (PND 60) induced by exposure to chronic restraint stress during adolescent period (PND 30-40). Rats were exposed to restraint stress (2 h/day for 10 days, PND 30-40). Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.03.004DOI Listing
March 2019
4.632 Impact Factor

Isotocin increases female avoidance of males in a coercive mating system: Assessing the social salience hypothesis of oxytocin in a fish species.

Horm Behav 2019 Mar 23;112:1-9. Epub 2019 Mar 23.

Section of Integrative Biology, University of Texas, Austin, TX 78712, USA.

The nonapeptide oxytocin (and its fish homolog isotocin (IT)) is an evolutionarily-conserved hormone associated with social behaviors across most vertebrate taxa. Oxytocin has traditionally been regarded as a prosocial hormone, but studies on social cognition in mammalian models suggest it may play a more nuanced role in modulating social discrimination based on social salience and stimulus valence. Here we test IT and its role in regulating female social decision-making and anxiety behaviors in a live-bearing fish with a male coercive mating system. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0018506X183034
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http://dx.doi.org/10.1016/j.yhbeh.2019.03.001DOI Listing
March 2019
3 Reads

Adult attachment and testosterone reactivity: Fathers' avoidance predicts changes in testosterone during the strange situation procedure.

Horm Behav 2019 Mar 27;112:10-19. Epub 2019 Mar 27.

Department of Psychology, University of Michigan, Ann Arbor, MI, United States of America.

We assessed parents' testosterone reactivity to the Strange Situation Procedure (SSP), a moderately stressful parent-infant interaction task that pulls for parental nurturance and caregiving behavior. Parents (146 mothers, 154 fathers) interacted with their 1-year-old infants, and saliva samples were obtained pre- and post-task to assess changes in testosterone. We examined whether testosterone reactivity differed between mothers and fathers, the extent to which parents' characteristic approaches to closeness (i. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.01.009DOI Listing
March 2019
3 Reads

The physiological significance of the circadian dynamics of the HPA axis: Interplay between circadian rhythms, allostasis and stress resilience.

Horm Behav 2019 Apr 15;110:77-89. Epub 2019 Mar 15.

Chemical & Biochemical Engineering Department, Rutgers University, Piscataway, NJ, United States of America; Biomedical Engineering Department, Rutgers University, Piscataway, NJ, United States of America; Department of Surgery, Rutgers - Robert Wood Johnson Medical School, New Brunswick, NJ, United States of America. Electronic address:

Circadian time-keeping mechanisms preserve homeostasis by synchronizing internal physiology with predictable variations in the environment and temporally organize the activation of physiological signaling mechanisms to promote survival and optimize the allocation of energetic resources. In this paper, we highlight the importance of the robust circadian dynamics of allostatic mediators, with a focus on the hypothalamic-pituitary-adrenal (HPA) axis, for the optimal regulation of host physiology and in enabling organisms to adequately respond and adapt to physiological stressors. We review studies showing how the chronic disruption of circadian rhythms can result in the accumulation of allostatic load, which impacts the appropriate functioning of physiological systems and diminishes the resilience of internal systems to adequately respond to subsequent stressors. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.018DOI Listing
April 2019
2 Reads
4.632 Impact Factor

Role of oxytocin in the medial preoptic area (MPOA) in the modulation of paternal behavior in mandarin voles.

Horm Behav 2019 Apr 6;110:46-55. Epub 2019 Mar 6.

Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an 710062, China. Electronic address:

Parental care plays an important role in individual survival and development in mammals. Many studies have focused on the mechanisms underlying maternal behavior. However, the underlying neural mechanisms of paternal behavior are less understood. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.014DOI Listing
April 2019
4 Reads
4.632 Impact Factor

Trait-specific effects of exogenous triiodothyronine on cytokine and behavioral responses to simulated systemic infection in male Siberian hamsters.

Horm Behav 2019 Apr 16;110:90-97. Epub 2019 Mar 16.

Inst. Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow, UK.

Seasonal changes in day length enhance and suppress immune function in a trait-specific manner. In Siberian hamsters (Phodopus sungorus) winter-like short days (SDs) increase blood leukocyte concentrations and adaptive T cell dependent immune responses, but attenuate innate inflammatory responses to simulated infections. Thyroid hormone (TH) signaling also changes seasonally and has been implicated in modulation of the reproductive axis by day length. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.017DOI Listing

Estrogen receptor-alpha knockouts and maternal memory in nulliparous rats.

Horm Behav 2019 Apr 4;110:40-45. Epub 2019 Mar 4.

Department of Biomedical Sciences, Tufts University, Cummings School of Veterinary Medicine, North Grafton, MA 01536, United States of America. Electronic address:

The current study investigated the role of estrogen receptor alpha (Esr1) in maternal memory in rats, comparing the induction and retention responses of Esr1 knockout (KO) and wild type (WT) nulliparous rats towards foster pups. Thirty days after completion of induction testing, subjects were tested for the retention of maternal care in their home cage and then for maternal behaviors in a novel cage. Both WT and Esr1 KO females displayed similar latencies to respond to foster young during the initial induction testing. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.002DOI Listing

No correlation between serum testosterone levels and state-level anger intensity in transgender people: Results from the European Network for the Investigation of Gender Incongruence.

Horm Behav 2019 Apr 2;110:29-39. Epub 2019 Mar 2.

Ghent University Hospital, Center for Sexology and Gender, C. Heymanslaan 10, 9000 Ghent, Belgium.

Introduction: Anger is a state of emotions ranging from irritation to intense rage. Aggression implies externalizing anger through destructive/punitive behaviour. The World Professional Association for Transgender Health (WPATH) Standards of Care, Edition 7 (SOC7) guidelines warn about aggression in transgender men (TM) on testosterone treatment. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.016DOI Listing
April 2019
1 Read

Dialogue intervention to youth amidst intractable conflict attenuates stress response to outgroup.

Horm Behav 2019 Apr 9;110:68-76. Epub 2019 Mar 9.

Interdisciplinary Center, Herzlia, Israel; Child Study Center, Yale University, New Haven, CT, United States of America. Electronic address:

Encounter with outgroup has been shown to elicit physiological stress response and when outgroup is perceived as threatening to one's own family and community, stress is higher. In such contexts, becoming familiar and learning to empathize with the other side may reduce stress. Building on the long-lasting Israeli-Palestinian conflict, we developed an eight-week group intervention focused on dialogue and empathy and tested it within a randomized controlled trial. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.013DOI Listing

Prolactin and avian parental care: New insights and unanswered questions.

Horm Behav 2019 Feb 27. Epub 2019 Feb 27.

Centre for Neuroendocrinology and Department of Anatomy, University of Otago, Dunedin 9016, New Zealand. Electronic address:

Parental care is a critical component of reproductive success for many species, but especially for birds that have high rates of parental care. While ample studies have shown strong, positive correlational relationships between the hormone prolactin and parental care in birds, few studies in a limited number of avian species have performed the causal experiments necessary to elucidate the exact roles of prolactin during these behaviors. Additionally, how prolactin acts in the brain to affect parental behaviors is still virtually unknown with the exception of a small number of studies in very few species. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.012DOI Listing
February 2019

Declining food availability, corticosterone, and migratory response in a nomadic, irruptive migrant.

Horm Behav 2019 Apr 6;110:56-67. Epub 2019 Mar 6.

School of Biological Sciences, Washington State University, Pullman, WA 99164, United States of America; Center for Reproductive Biology, Washington State University, Pullman, WA 99164, United States of America; Department of Biology, Loyola Marymount University, Los Angeles, CA 90045, United States of America.

While obligate migrants time their movements to respond to predictable changes in the environment, facultative migration is characterized by more variable movements that are driven by unpredictable changes in resource availability. The proximate cues that trigger facultative migrations and the endocrine mechanisms involved in these responses remain poorly understood, though corticosterone may be a key mediator of facultative migration due to its effects on activity and metabolic processes. We conducted experiments in the fall and spring to examine the response of pine siskins (Spinus pinus), a facultative migrant, to a two-stage food restriction. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.007DOI Listing
April 2019
1 Read

Non-model species deliver a non-model result: Nutria female fetuses neighboring males in utero have lower testosterone.

Horm Behav 2019 Feb 23. Epub 2019 Feb 23.

The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel. Electronic address:

Neighboring fetuses may impact their siblings in various respects, depending on their in utero location and sex. The effects of the intrauterine position (IUP) are widely studied in model organisms, especially laboratory bred murine strains that are characterized by short gestations and altricial offspring. In some species, the proximity to a male fetus and its higher circulating testosterone masculinizes neighboring female fetuses. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.011DOI Listing
February 2019

The less weight loss due to modest food restriction drove more fat accumulation in striped hamsters refed with high-fat diet.

Horm Behav 2019 Apr 23;110:19-28. Epub 2019 Feb 23.

College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China. Electronic address:

Food restriction (FR) has been commonly used to decrease body fat, reducing the risk of overweight in humans and animals. However, the lost weight has been shown to be followed by overweight when food restriction ends. It remains uncertain whether the weight loss drives the overweight, or not. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.010DOI Listing

Organizational effects of testosterone on learning strategy preference and muscarinic receptor binding in prepubertal rats.

Horm Behav 2019 Apr 22;110:1-9. Epub 2019 Feb 22.

Tulane University, Department of Psychology, New Orleans, LA 70118, United States of America; Tulane University, Program in Neuroscience, New Orleans, LA 70118, United States of America.

Prior to puberty, male rats, but not female rats, prefer a striatum-based stimulus-response learning strategy rather than a hippocampus-based place strategy on a water maze task that can be solved using either strategy. Neurochemically, learning strategy preference has been linked to the ratio of cholinergic muscarinic receptor binding in the hippocampus relative to the striatum, with lower ratios displayed by males compared to females and by stimulus-response learners compared to place learners. Sex differences in a variety of different behaviors are established by the organizational influence of testosterone on brain development. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.005DOI Listing

Establishment of partner preference in male rats: Effect of prenatal letrozole and sexual experience.

Horm Behav 2019 Mar 19;109:56-63. Epub 2019 Feb 19.

Departamento de Farmacobiología, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, México. Electronic address:

Repeated testing for masculine sexual behavior influences female sex preference in males. Males perinatally treated with aromatase inhibitors show male preference, but also copulate with the receptive female. Such copulation modifies sex preference most likely because of its rewarding properties. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.009DOI Listing

Chronic exposure to inorganic mercury alters stress responses in male prairie voles (Microtus ochrogaster).

Horm Behav 2019 Mar 15;109:53-55. Epub 2019 Feb 15.

Department of Pharmacology and Physiology, Oklahoma State University Center for Health Sciences, Tulsa, OK 74107, United States of America. Electronic address:

Male, but not female, prairie voles that experience chronic exposure to inorganic mercury display aberrant social behavior - avoiding unfamiliar conspecifics rather than approaching them. The mechanisms that underlie such behavioral changes are unknown, but likely involve the hypothalamus-pituitary-adrenal (HPA) axis. We tested this hypothesis by providing voles of both sexes with mercury chloride in their drinking water for ten weeks and then staging same-sex dyadic encounters after which plasma was assayed for corticosterone as an index of HPA activity. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.008DOI Listing

No difference in cognitive performance or gender role behavior between men with and without hypospadias.

Horm Behav 2019 Mar 20;109:64-70. Epub 2019 Feb 20.

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Department of Pediatric Endocrinology, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.

Background: Hypospadias is a common malformation of the male external genitalia that results in urethral displacement with different levels of severity. Male genital development during the fetal period is dependent on androgen function, while the etiology of hypospadias differs and can be multifactorial. The psychosocial outcome is sometimes affected, but according to several studies acceptable. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.004DOI Listing
March 2019
19 Reads

Taurine modulates the stress response in zebrafish.

Horm Behav 2019 Mar 14;109:44-52. Epub 2019 Feb 14.

Graduate Program in Pharmacology, Federal University of Santa Maria, 1000 Roraima Avenue, Santa Maria, RS 97105-900, Brazil; Graduate Program in Bio-Experimentation, University of Passo Fundo (UPF), BR 285, Passo Fundo, RS 99052-900, Brazil; Graduate Program in Environmental Sciences, University of Passo Fundo (UPF), BR 285, Passo Fundo, RS 99052-900, Brazil.

The zebrafish (Danio rerio) is used as an emergent model organism to investigate the behavioral and physiological responses to stress. The anxiolytic-like effects of taurine in zebrafish support the existence of different mechanisms of action, which can play a role in preventing stress-related disorders (i.e. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.006DOI Listing
March 2019
3 Reads

Acute stress enhances general-knowledge semantic memory.

Horm Behav 2019 Mar 13;109:38-43. Epub 2019 Feb 13.

Department of Psychology, Tufts University, 490 Boston Ave., Medford, MA 02155, United States of America.

Acute psychological stress consistently impairs episodic memory, which consists of memory for events that are associated with a specific context. However, researchers have not yet established how stress influences semantic memory, which consists of general knowledge that is devoid of context. In the present study, participants either underwent stress induction or a control task prior to taking a trivia test that was designed to measure semantic memory. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.003DOI Listing
March 2019
9 Reads

Effect of testosterone blockers on male aggression, song and parental care in an arctic passerine, the Lapland longspur (Calcarius lapponicus).

Horm Behav 2019 Apr 23;110:10-18. Epub 2019 Feb 23.

Department of Neurobiology, Physiology & Behavior, University of California, One Shields Ave., Davis, CA 95616, USA. Electronic address:

In many passerine birds, testosterone stimulates song and aggression but inhibits paternal care, but few studies have explored whether such effects can be reversed with testosterone blockers. We explored the effect of testosterone blockers on song, aggression and paternal care of Lapland longspurs (Calcarius lapponicus), an arctic passerine with a short breeding season. Twenty-one "blocker males" received implants containing an androgen receptor blocker and an aromatase inhibitor, compared to 27 control males with empty or no implants. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.001DOI Listing
April 2019
1 Read

Oxytocin receptor knockout prairie voles generated by CRISPR/Cas9 editing show reduced preference for social novelty and exaggerated repetitive behaviors.

Horm Behav 2018 Nov 8. Epub 2018 Nov 8.

Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza-Aoba, Aoba-ku, Sendai 980-0845, Miyagi, Japan. Electronic address:

Behavioral neuroendocrinology has benefited tremendously from the use of a wide range of model organisms that are ideally suited for particular questions. However, in recent years the ability to manipulate the genomes of laboratory strains of mice has led to rapid advances in our understanding of the role of specific genes, circuits and neural populations in regulating behavior. While genome manipulation in mice has been a boon for behavioral neuroscience, the intensive focus on the mouse restricts the diversity in behavioral questions that can be investigated using state-of-the-art techniques. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2018.10.011DOI Listing
November 2018
2 Reads

Sex hormones and stroke: Beyond estrogens.

Horm Behav 2018 Nov 20. Epub 2018 Nov 20.

Women's Health in Neuroscience Program, Neuroscience and Experimental Therapeutics, Texas A&M College of Medicine, Bryan, TX 77807, United States of America.

Stroke risk and poor stroke outcomes in postmenopausal women have usually beeen attributed to decreased levels of estrogen. However, two lines of evidence suggest that this hormone may not be solely responsible for elevated stroke risk in this population. First, the increased risk for CVD and stroke occurs much earlier than menopause at a time when estrogen levels are not yet reduced. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2018.10.010DOI Listing
November 2018
2 Reads

Access to a high resource environment protects against accelerated maturation following early life stress: A translational animal model of high, medium and low security settings.

Horm Behav 2019 Mar 1. Epub 2019 Mar 1.

School of Arts & Sciences, Health Psychology Program, Massachusetts College of Pharmacy and Health Sciences, Boston, MA 02115, United States. Electronic address:

Early life exposure to a low security setting, characterized by a scarcity of resources and limited food access, increases the risk for psychiatric illness and metabolic dysfunction. We utilized a translational rat model to mimic a low security environment and determined how this manipulation affected offspring behavior, metabolism, and puberty. Because food insecurity in humans is associated with reduced access to healthy food options the "low security" rat manipulation combined a Western diet with exposure to a limited bedding and nesting manipulation (WD-LB). Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.01.003DOI Listing
March 2019
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Differential effects of androgens, estrogens and socio-sexual context on sexual behaviors in the castrated male goat.

Horm Behav 2019 Mar 1;109:10-17. Epub 2019 Feb 1.

Rutgers University, New Brunswick, NJ, USA. Electronic address:

The behavioral and endocrine activation of sexual behaviors exhibited by male goats, especially self-enurination (SE), is poorly understood. In the first experiment, to assess the influence of socio-sexual context on SE in bucks, the effects of distance from does, the presence of estrous versus non-estrous does and the presence of another buck on SE and courtship frequencies of intact male goats (bucks; n = 12) were tested using a unique behavior test apparatus. For experiments 2 and 3, to test the relative contributions of sex steroid hormones and socio-sexual context on SE, castrated male goats (wethers; n = 20) were randomly divided into five groups and injected for seven weeks with one of the following: 25 mg testosterone propionate (T), 25 mg dihydrotestosterone propionate (DHT), 100 μg estradiol benzoate (E), 100 μg E and 25 mg DHT (E + DHT), or oil (CON). Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.01.008DOI Listing
March 2019
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Effects of ovarian hormones on the emission of 50-kHz ultrasonic vocalizations during distributed clitoral stimulation in the rat.

Horm Behav 2019 Mar 30;109:1-9. Epub 2019 Jan 30.

Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC, Canada. Electronic address:

Fifty-kHz ultrasonic vocalizations (USVs) are emitted by adult rats during appetitive phases of behavior in response to stimuli thought to be associated with a positive affective state. In particular, 50-kHz USVs with rapid frequency oscillations, known as trills and flat-trills, in which these oscillations are flanked by a monotonic portion, are together positively correlated with appetitive behaviors such as rough and tumble play, drug and natural reward, and mating. Female rats produce 50-kHz USVs during a variety of sexual contexts, yet data are still vague as female sexual behavior is seldom studied on its own. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.01.005DOI Listing

Testosterone, cortisol, and status-striving personality features: A review and empirical evaluation of the Dual Hormone hypothesis.

Horm Behav 2019 Mar 1;109:25-37. Epub 2019 Feb 1.

Department of Psychology, University of New Mexico, Albuquerque, NM, USA.

Decades of research in behavioral endocrinology has implicated the gonadal hormone testosterone in the regulation of mating effort, often expressed in primates in the form of aggressive and/or status-striving behavior. Based on the idea that neuroendocrine axes influence each other, recent work among humans has proposed that links between testosterone and indices of status-striving are rendered conditional by the effects of glucocorticoids. The Dual Hormone hypothesis is one particular instance of this argument, predicting that cortisol blocks the effects of testosterone on dominance, aggression, and risk-taking in humans. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.01.006DOI Listing
March 2019
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Influence of glucocorticoid and mineralocorticoid receptor stimulation on task switching.

Horm Behav 2019 Mar 1;109:18-24. Epub 2019 Feb 1.

Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Berlin, Germany.

The influence of stress on executive functions has been demonstrated in numerous studies and is potentially mediated by the stress-induced cortisol release. Yet, the impact of cortisol on cognitive flexibility and task switching in particular remains equivocal. In this study, we investigated the influence of pharmacological glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) stimulation, two corticosteroid receptor types known to be responsible for cortisol effects on the brain. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.01.007DOI Listing

Trick or treat? Evaluating contributing factors and sex-differences for developmental effects of maternal depression and its treatment.

Horm Behav 2019 Jan 23. Epub 2019 Jan 23.

Department of Psychology, Wayne State University, Detroit, MI, USA. Electronic address:

Maternal depression and treatment with selective serotonin reuptake inhibitors (SSRIs), the most common form of pharmaceutical intervention, can both have an impact on infant development. As such, it is difficult for healthcare providers to recommend a course of treatment to expectant mothers suffering from depression, or to women on antidepressant medication prior to pregnancy. This review will discuss the existing research on the developmental impacts of maternal depression and its treatment with SSRIs, with a particular focus on contributing factors that complicate our attempt to disentangle the consequences of maternal depression and its treatment such as the timing or severity of the depression. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.01.004DOI Listing
January 2019
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Activation of androgen receptors protects intact male mice from memory impairments caused by aromatase inhibition.

Horm Behav 2019 Jan 17. Epub 2019 Jan 17.

Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, United States of America. Electronic address:

Although 17β-estradiol (E) is known to regulate hippocampal function, the specific contributions of hippocampally-synthesized E remain unclear. Infusion of the aromatase inhibitor letrozole into the dorsal hippocampus (DH) of ovariectomized mice disrupts object recognition and object placement memory consolidation, suggesting that DH-synthesized E is essential for memory. However, the role of DH-synthesized E in memory among male rodents is unknown. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.01.002DOI Listing
January 2019
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The difference a day makes: Breeding remodels hearing, hormones and behavior in female Cope's gray treefrogs (Hyla chrysoscelis).

Horm Behav 2019 Feb 16;108:62-72. Epub 2019 Jan 16.

Department of Biology, Swarthmore College, 500 College Avenue, Swarthmore, PA 19081, USA. Electronic address:

In seasonal breeders, there are behavioral, endocrine, and neural adaptations that promote the sexual receptivity of females and tune their sensory systems to detect and discriminate among advertising males and to successfully copulate. What happens immediately after this key life history event is unclear, but this transitional moment offers a window into the mechanisms that remodel sexual phenotypes. In this study of wild female Cope's gray treefrogs (Hyla chrysoscelis), we tested the hypothesis that oviposition results in a suite of coordinated changes in the sexual phenotype. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.01.001DOI Listing
February 2019
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Site-specific effects of aromatase inhibition on the activation of male sexual behavior in male Japanese quail (Coturnix japonica).

Horm Behav 2019 Feb 9;108:42-49. Epub 2019 Jan 9.

GIGA Neurosciences, University of Liège, Belgium. Electronic address:

Aromatization within the medial preoptic nucleus (POM) is essential for the expression of male copulatory behavior in Japanese quail. However, several nuclei within the social behavior network (SBN) also express aromatase. Whether aromatase in these loci participates in the behavioral activation is not known. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2018.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377315PMC
February 2019
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Energy balance but not competitive environment corresponds with allostatic load during development in an Old World monkey.

Horm Behav 2019 Feb 4;108:30-41. Epub 2019 Jan 4.

Columbia University, Department of Ecology, Evolution, and Environmental Biology, United States of America; New York Consortium in Evolutionary Primatology, United States of America.

Primates develop slowly relative to their body size, a pattern posited to result from ecological risk aversion. Little is known, however, about how energy balance contributes to allostatic load in juveniles. Using data collected over 8 consecutive months, we examined variation in energy balance (as measured by urinary C-peptide) and how energy balance, life history status, and social competition related to allostatic load (as measured by deviation from baseline fecal glucocorticoid metabolites, dfGCs) in 41 wild juvenile blue monkeys from 3 social groups. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2018.12.014DOI Listing
February 2019
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Sex differences in sleep and sleep loss-induced cognitive deficits: The influence of gonadal hormones.

Horm Behav 2019 Feb 15;108:50-61. Epub 2019 Jan 15.

Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Males and females can respond differentially to the same environmental stimuli and experimental conditions. Chronic sleep loss is a frequent and growing problem in many modern societies and has a broad variety of negative outcomes for health and well-being. While much has been done to explore the deleterious effects of sleep deprivation (SD) on cognition in both human and animal studies over the last few decades, very little attention has been paid to the part played by sex differences and gonadal steroids in respect of changes in cognitive functions caused by sleep loss. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2018.12.013DOI Listing
February 2019
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Nanoparticle encapsulation increases the brain penetrance and duration of action of intranasal oxytocin.

Horm Behav 2019 Feb 30;108:20-29. Epub 2018 Dec 30.

Department of Pharmaceutical Sciences, Mercer University College of Pharmacy, Mercer University Health Sciences Center, Atlanta, GA, USA. Electronic address:

The blood-brain barrier (BBB) limits the therapeutic use of large molecules as it prevents them from passively entering the brain following administration by conventional routes. It also limits the capacity of researchers to study the role of large molecules in behavior, as it often necessitates intracerebroventricular administration. Oxytocin is a large-molecule neuropeptide with pro-social behavioral effects and therapeutic promise for social-deficit disorders. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2018.12.011DOI Listing
February 2019
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Implicit associations to infant cry: Genetics and early care experiences influence caregiving propensities.

Horm Behav 2019 Feb 27;108:1-9. Epub 2018 Dec 27.

Social & Affiliative Neuroscience Lab, Division of Psychology - School of Humanities and Social Sciences, Nanyang Technological University, Singapore; Department of Psychology and Cognitive Sciences, University of Trento, Trento, Italy.

Adults' sensitive appraisal of and response to infant cry play a foundational role in child development. Employing a gene × environment (G × E) approach, this study investigated the interaction of genetic polymorphisms of the serotonin transporter gene (5-HTTLPR) and oxytocin receptor genes (OXTR; rs53576, rs2254298) with early parental care experiences in influencing adults' implicit associations to infant cry. Eighty nulliparous adults (40 females, 40 males) responded to the Parental Acceptance-Rejection Questionnaire (PARQ), a measure of early care experiences, and participated in a Single Category Implicit Association Task (SC-IAT) to measure implicit associations to infant cry. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2018.12.012DOI Listing
February 2019
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Individual differences in the biological basis of androphilia in mice and men.

Horm Behav 2018 Dec 26. Epub 2018 Dec 26.

Neuroscience Program, Michigan State University, 293 Farm Lane, East Lansing, MI 48824, USA; Department of Psychology, Memorial University of Newfoundland, St. John's, NL A1B 3X9, Canada. Electronic address:

For nearly 60 years since the seminal paper from W.C Young and colleagues (Phoenix et al., 1959), the principles of sexual differentiation of the brain and behavior have maintained that female-typical sexual behaviors (e. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2018.12.006DOI Listing
December 2018
2 Reads